PRKY

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative thymic T cell selection (GO:0045060)4.93702419
2activated T cell proliferation (GO:0050798)4.93562745
3negative T cell selection (GO:0043383)4.89726110
4positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.89458905
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.55201662
6negative regulation of cell killing (GO:0031342)4.55201662
7positive regulation of gamma-delta T cell activation (GO:0046645)4.03818140
8negative regulation of cAMP-mediated signaling (GO:0043951)3.91907611
9cellular response to interleukin-15 (GO:0071350)3.82161939
10response to interleukin-15 (GO:0070672)3.76621576
11interferon-gamma production (GO:0032609)3.74319216
12regulation of B cell receptor signaling pathway (GO:0050855)3.72397675
13positive T cell selection (GO:0043368)3.70086356
14positive regulation of T cell differentiation in thymus (GO:0033089)3.63406896
15tolerance induction (GO:0002507)3.47901722
16positive regulation of granulocyte differentiation (GO:0030854)3.47589219
17T cell selection (GO:0045058)3.40470684
18regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.39279982
19positive thymic T cell selection (GO:0045059)3.38689726
20regulation of gamma-delta T cell differentiation (GO:0045586)3.31082870
21regulation of T cell receptor signaling pathway (GO:0050856)3.29620853
22L-fucose catabolic process (GO:0042355)3.28580598
23fucose catabolic process (GO:0019317)3.28580598
24L-fucose metabolic process (GO:0042354)3.28580598
25regulation of memory T cell differentiation (GO:0043380)3.26496075
26thymic T cell selection (GO:0045061)3.26493051
27mast cell activation (GO:0045576)3.24329490
28regulation of gamma-delta T cell activation (GO:0046643)3.16865677
29antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.13262509
30epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.10358913
31alpha-beta T cell differentiation (GO:0046632)3.08154564
32negative regulation of T cell mediated immunity (GO:0002710)3.07476303
33regulation of alpha-beta T cell proliferation (GO:0046640)3.06122010
34negative regulation of T-helper cell differentiation (GO:0045623)3.05059401
35negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.05059401
36DNA deamination (GO:0045006)3.03960077
37positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.03278504
38mast cell activation involved in immune response (GO:0002279)3.01861188
39mast cell degranulation (GO:0043303)3.01861188
40negative regulation of lymphocyte mediated immunity (GO:0002707)3.01411040
41behavioral response to nicotine (GO:0035095)2.98834887
42positive regulation of alpha-beta T cell proliferation (GO:0046641)2.98290474
43regulation of regulatory T cell differentiation (GO:0045589)2.94674416
44negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.93999995
45positive regulation of defense response to virus by host (GO:0002230)2.93549219
46antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.85861894
47antigen processing and presentation of endogenous antigen (GO:0019883)2.82644022
48regulation of B cell differentiation (GO:0045577)2.82104982
49axoneme assembly (GO:0035082)2.81667034
50neural tube formation (GO:0001841)2.80873393
51alpha-beta T cell activation (GO:0046631)2.80561946
52positive regulation of B cell differentiation (GO:0045579)2.79860205
53regulation of hypersensitivity (GO:0002883)2.79020974
54leukocyte aggregation (GO:0070486)2.77782780
55negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.76465566
56adaptation of signaling pathway (GO:0023058)2.75718025
57cellular extravasation (GO:0045123)2.74424758
58T cell migration (GO:0072678)2.74399343
59positive regulation of antigen processing and presentation (GO:0002579)2.72431908
60regulation of T-helper 1 type immune response (GO:0002825)2.72234747
61negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.66531366
62negative regulation of translation, ncRNA-mediated (GO:0040033)2.66531366
63regulation of translation, ncRNA-mediated (GO:0045974)2.66531366
64regulation of interleukin-1 beta secretion (GO:0050706)2.63912042
65T cell differentiation (GO:0030217)2.63441862
66protein K11-linked deubiquitination (GO:0035871)2.63421170
67positive regulation of T-helper 1 type immune response (GO:0002827)2.62309449
68phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.61817251
69regulation of germinal center formation (GO:0002634)2.61287241
70indole-containing compound catabolic process (GO:0042436)2.60213714
71indolalkylamine catabolic process (GO:0046218)2.60213714
72tryptophan catabolic process (GO:0006569)2.60213714
73regulation of alpha-beta T cell activation (GO:0046634)2.60112689
74negative regulation of adaptive immune response (GO:0002820)2.59957571
75negative regulation of alpha-beta T cell differentiation (GO:0046639)2.59162423
76regulation of natural killer cell mediated immunity (GO:0002715)2.58403372
77regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.58403372
78indolalkylamine metabolic process (GO:0006586)2.58204950
79T cell proliferation (GO:0042098)2.52897389
80CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.52206112
81antigen receptor-mediated signaling pathway (GO:0050851)2.51312958
82positive regulation of DNA recombination (GO:0045911)2.50437053
83rRNA catabolic process (GO:0016075)2.50362694
84regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.49866936
85antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.49222274
86negative regulation of mast cell activation (GO:0033004)2.48903523
87regulation of T cell mediated cytotoxicity (GO:0001914)2.48653592
88negative regulation of alpha-beta T cell activation (GO:0046636)2.48251570
89positive regulation of alpha-beta T cell activation (GO:0046635)2.46957953
90positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.45876134
91regulation of MHC class I biosynthetic process (GO:0045343)2.44553871
92platelet dense granule organization (GO:0060155)2.44413953
93histone H3-K9 modification (GO:0061647)2.44338449
94positive regulation of interleukin-1 beta secretion (GO:0050718)2.43444975
95regulation of leukocyte mediated cytotoxicity (GO:0001910)2.43415409
96regulation of alpha-beta T cell differentiation (GO:0046637)2.43042708
97negative regulation of interleukin-1 beta production (GO:0032691)2.42801155
98T cell receptor signaling pathway (GO:0050852)2.42729011
99negative regulation of leukocyte mediated immunity (GO:0002704)2.42412821
100tryptophan metabolic process (GO:0006568)2.42348176

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.38121890
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.02658070
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.60926060
4ZNF274_21170338_ChIP-Seq_K562_Hela3.21749451
5* IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.68390871
6RUNX_20019798_ChIP-Seq_JUKART_Human2.58363314
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.35832803
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.32538400
9NOTCH1_21737748_ChIP-Seq_TLL_Human2.17076171
10VDR_22108803_ChIP-Seq_LS180_Human2.12756388
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.05207120
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.04674831
13MYB_26560356_Chip-Seq_TH2_Human2.00811460
14IRF8_21731497_ChIP-ChIP_J774_Mouse1.93272072
15PCGF2_27294783_Chip-Seq_ESCs_Mouse1.87444654
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.85693223
17ZFP57_27257070_Chip-Seq_ESCs_Mouse1.83844925
18GATA3_26560356_Chip-Seq_TH2_Human1.78170049
19GBX2_23144817_ChIP-Seq_PC3_Human1.77965755
20GATA3_27048872_Chip-Seq_THYMUS_Human1.69899733
21POU3F2_20337985_ChIP-ChIP_501MEL_Human1.69630943
22IGF1R_20145208_ChIP-Seq_DFB_Human1.67226637
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.65807087
24LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.62673536
25PCGF2_27294783_Chip-Seq_NPCs_Mouse1.59909847
26STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.54099220
27P300_19829295_ChIP-Seq_ESCs_Human1.49178702
28EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.45460693
29ELF1_17652178_ChIP-ChIP_JURKAT_Human1.44258342
30FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.42799956
31SUZ12_27294783_Chip-Seq_NPCs_Mouse1.38985246
32AR_21572438_ChIP-Seq_LNCaP_Human1.38913834
33NFE2_27457419_Chip-Seq_LIVER_Mouse1.38259097
34BCAT_22108803_ChIP-Seq_LS180_Human1.37753321
35HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.35404201
36BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.34173329
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33203238
38IRF1_19129219_ChIP-ChIP_H3396_Human1.33182316
39ER_23166858_ChIP-Seq_MCF-7_Human1.32661363
40EZH2_22144423_ChIP-Seq_EOC_Human1.30026488
41POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.29066669
42TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29066669
43EWS_26573619_Chip-Seq_HEK293_Human1.28744376
44MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.28675600
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28447688
46IRF8_27001747_Chip-Seq_BMDM_Mouse1.26809348
47TAF15_26573619_Chip-Seq_HEK293_Human1.26446973
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.26325373
49MYB_26560356_Chip-Seq_TH1_Human1.25157806
50VDR_24787735_ChIP-Seq_THP-1_Human1.24781752
51SMAD_19615063_ChIP-ChIP_OVARY_Human1.24769780
52SCL_19346495_ChIP-Seq_HPC-7_Human1.24014942
53AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23662710
54EZH2_27294783_Chip-Seq_NPCs_Mouse1.23571764
55CBP_20019798_ChIP-Seq_JUKART_Human1.22370595
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22370595
57FUS_26573619_Chip-Seq_HEK293_Human1.21292654
58PRDM14_20953172_ChIP-Seq_ESCs_Human1.18430926
59TCF4_23295773_ChIP-Seq_U87_Human1.18150467
60STAT3_23295773_ChIP-Seq_U87_Human1.16204233
61TP53_22573176_ChIP-Seq_HFKS_Human1.16115044
62SMRT_27268052_Chip-Seq_Bcells_Human1.14691712
63SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.14361599
64PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13948778
65CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13833702
66NANOG_19829295_ChIP-Seq_ESCs_Human1.12981452
67SOX2_19829295_ChIP-Seq_ESCs_Human1.12981452
68SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.12745041
69TCF4_22108803_ChIP-Seq_LS180_Human1.12135433
70RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.11993576
71VDR_23849224_ChIP-Seq_CD4+_Human1.11765950
72GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09319841
73UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08604291
74ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06471998
75PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06425193
76VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06149693
77FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06095370
78GATA3_21878914_ChIP-Seq_MCF-7_Human1.04948719
79MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04899688
80AR_20517297_ChIP-Seq_VCAP_Human1.04325047
81AR_25329375_ChIP-Seq_VCAP_Human1.02150463
82FLI1_21867929_ChIP-Seq_TH2_Mouse1.02001793
83FOXA1_27270436_Chip-Seq_PROSTATE_Human1.01760027
84FOXA1_25329375_ChIP-Seq_VCAP_Human1.01760027
85CRX_20693478_ChIP-Seq_RETINA_Mouse1.01749378
86STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.98456562
87SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.97955228
88EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.97819774
89VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.97442299
90TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95979209
91CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.94695412
92SMAD4_21799915_ChIP-Seq_A2780_Human0.93897626
93OCT4_21477851_ChIP-Seq_ESCs_Mouse0.93720410
94RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.92931727
95TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.91363507
96CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.91172888
97GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.90825756
98NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90566394
99RUNX2_22187159_ChIP-Seq_PCA_Human0.90042630
100MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.89569028

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.15326404
2MP0005671_abnormal_response_to3.15053386
3MP0003724_increased_susceptibility_to2.98097463
4MP0003763_abnormal_thymus_physiology2.82354629
5MP0001800_abnormal_humoral_immune2.66156006
6MP0001986_abnormal_taste_sensitivity2.52430844
7MP0008877_abnormal_DNA_methylation2.50097169
8MP0000569_abnormal_digit_pigmentation2.37342243
9MP0000685_abnormal_immune_system2.30569188
10MP0003436_decreased_susceptibility_to2.25838268
11MP0005387_immune_system_phenotype2.19842843
12MP0001790_abnormal_immune_system2.19842843
13MP0002723_abnormal_immune_serum2.18204374
14MP0005000_abnormal_immune_tolerance2.16503560
15MP0002420_abnormal_adaptive_immunity2.07376054
16MP0001819_abnormal_immune_cell2.06327763
17MP0002452_abnormal_antigen_presenting1.95417013
18MP0002148_abnormal_hypersensitivity_rea1.94725592
19MP0005075_abnormal_melanosome_morpholog1.93182310
20MP0003195_calcinosis1.89570722
21MP0005025_abnormal_response_to1.85864706
22MP0009785_altered_susceptibility_to1.79663667
23MP0002277_abnormal_respiratory_mucosa1.77388633
24MP0002138_abnormal_hepatobiliary_system1.76743384
25MP0005551_abnormal_eye_electrophysiolog1.71217678
26MP0004043_abnormal_pH_regulation1.70813898
27MP0006082_CNS_inflammation1.69874682
28MP0004142_abnormal_muscle_tone1.68764556
29MP0002163_abnormal_gland_morphology1.65388382
30MP0002405_respiratory_system_inflammati1.65350992
31MP0005174_abnormal_tail_pigmentation1.63951372
32MP0004381_abnormal_hair_follicle1.63365013
33MP0008872_abnormal_physiological_respon1.62135891
34MP0002419_abnormal_innate_immunity1.61939307
35MP0005310_abnormal_salivary_gland1.61136671
36MP0003787_abnormal_imprinting1.59941697
37MP0002398_abnormal_bone_marrow1.59645925
38MP0000372_irregular_coat_pigmentation1.57651727
39MP0000716_abnormal_immune_system1.56888227
40MP0006072_abnormal_retinal_apoptosis1.52211784
41MP0009764_decreased_sensitivity_to1.51075670
42MP0001968_abnormal_touch/_nociception1.49381743
43MP0000689_abnormal_spleen_morphology1.47819879
44MP0002132_abnormal_respiratory_system1.45548069
45MP0000703_abnormal_thymus_morphology1.45321357
46MP0006292_abnormal_olfactory_placode1.43973468
47MP0002102_abnormal_ear_morphology1.39731553
48MP0002638_abnormal_pupillary_reflex1.36128281
49MP0003136_yellow_coat_color1.35305139
50MP0001501_abnormal_sleep_pattern1.32366040
51MP0009333_abnormal_splenocyte_physiolog1.31226062
52MP0010155_abnormal_intestine_physiology1.30412294
53MP0002254_reproductive_system_inflammat1.30135639
54MP0002722_abnormal_immune_system1.25538878
55MP0001845_abnormal_inflammatory_respons1.25385320
56MP0000015_abnormal_ear_pigmentation1.24995651
57MP0003866_abnormal_defecation1.19856256
58MP0002429_abnormal_blood_cell1.14667548
59MP0005253_abnormal_eye_physiology1.06444487
60MP0003172_abnormal_lysosome_physiology1.05784431
61MP0003646_muscle_fatigue1.05671271
62MP0002166_altered_tumor_susceptibility1.04109465
63MP0004885_abnormal_endolymph1.02336302
64MP0002736_abnormal_nociception_after1.00243858
65MP0005084_abnormal_gallbladder_morpholo0.99683706
66MP0005377_hearing/vestibular/ear_phenot0.99031341
67MP0003878_abnormal_ear_physiology0.99031341
68MP0001533_abnormal_skeleton_physiology0.98764236
69MP0002653_abnormal_ependyma_morphology0.97418745
70MP0002876_abnormal_thyroid_physiology0.96389340
71MP0005464_abnormal_platelet_physiology0.96350985
72MP0004742_abnormal_vestibular_system0.93106447
73MP0008995_early_reproductive_senescence0.92210805
74MP0000465_gastrointestinal_hemorrhage0.89124416
75MP0001984_abnormal_olfaction0.89047517
76MP0001873_stomach_inflammation0.88551739
77MP0008469_abnormal_protein_level0.85616672
78MP0008875_abnormal_xenobiotic_pharmacok0.84913517
79MP0009765_abnormal_xenobiotic_induced0.84443268
80MP0002933_joint_inflammation0.83969836
81MP0008961_abnormal_basal_metabolism0.81704235
82MP0000230_abnormal_systemic_arterial0.81367000
83MP0009745_abnormal_behavioral_response0.79218853
84MP0001764_abnormal_homeostasis0.78272580
85MP0004130_abnormal_muscle_cell0.76801024
86MP0001851_eye_inflammation0.76489498
87MP0004947_skin_inflammation0.75045339
88MP0002095_abnormal_skin_pigmentation0.74856230
89MP0001919_abnormal_reproductive_system0.73520038
90MP0005379_endocrine/exocrine_gland_phen0.71802890
91MP0003303_peritoneal_inflammation0.69817293
92MP0000427_abnormal_hair_cycle0.69596416
93MP0002396_abnormal_hematopoietic_system0.68929599
94MP0002837_dystrophic_cardiac_calcinosis0.68875982
95MP0001486_abnormal_startle_reflex0.67919336
96MP0008058_abnormal_DNA_repair0.67656527
97MP0003252_abnormal_bile_duct0.67379775
98MP0009278_abnormal_bone_marrow0.66775241
99MP0005410_abnormal_fertilization0.65088237
100MP0003011_delayed_dark_adaptation0.64974198

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)3.84612525
2Pancreatic cysts (HP:0001737)3.78771408
3Elevated erythrocyte sedimentation rate (HP:0003565)3.70838759
4Stomach cancer (HP:0012126)3.65910593
5Panhypogammaglobulinemia (HP:0003139)3.54999820
6Severe combined immunodeficiency (HP:0004430)3.49882775
7Congenital stationary night blindness (HP:0007642)3.45916776
8Pancreatic fibrosis (HP:0100732)3.44262770
9Abnormality of T cell number (HP:0011839)3.34037548
10T lymphocytopenia (HP:0005403)3.22088571
11Abnormal delayed hypersensitivity skin test (HP:0002963)3.16387873
12Myositis (HP:0100614)3.16375084
13True hermaphroditism (HP:0010459)3.15703986
14IgG deficiency (HP:0004315)3.15491882
15Absent rod-and cone-mediated responses on ERG (HP:0007688)3.14765841
16Molar tooth sign on MRI (HP:0002419)3.13159113
17Abnormality of midbrain morphology (HP:0002418)3.13159113
18Abnormal rod and cone electroretinograms (HP:0008323)3.04861819
19Chronic hepatic failure (HP:0100626)2.99411605
20Thyroiditis (HP:0100646)2.91377112
21Pustule (HP:0200039)2.89505517
22Abnormality of eosinophils (HP:0001879)2.83285761
23Decreased central vision (HP:0007663)2.80380709
24Nephronophthisis (HP:0000090)2.73062804
25Abnormality of T cells (HP:0002843)2.71136829
26Optic neuritis (HP:0100653)2.69856951
27Retrobulbar optic neuritis (HP:0100654)2.69856951
28Abnormality of the renal cortex (HP:0011035)2.68877287
29Recurrent fungal infections (HP:0002841)2.68798305
30Encephalitis (HP:0002383)2.63718515
31Eosinophilia (HP:0001880)2.57720070
32Recurrent cutaneous fungal infections (HP:0011370)2.55345322
33Chronic mucocutaneous candidiasis (HP:0002728)2.55345322
34Abolished electroretinogram (ERG) (HP:0000550)2.50598169
35Abnormality of the renal medulla (HP:0100957)2.47698695
36Leukocytosis (HP:0001974)2.42244334
37Combined immunodeficiency (HP:0005387)2.40026530
38Hyperventilation (HP:0002883)2.36849038
39Orchitis (HP:0100796)2.33723005
40Attenuation of retinal blood vessels (HP:0007843)2.32229537
41Decreased electroretinogram (ERG) amplitude (HP:0000654)2.27074548
42Hypoproteinemia (HP:0003075)2.23585710
43Abnormality of DNA repair (HP:0003254)2.19540506
44Renal cortical cysts (HP:0000803)2.18599054
45Febrile seizures (HP:0002373)2.18344283
46Abnormality of T cell physiology (HP:0011840)2.16177715
47Colon cancer (HP:0003003)2.15941800
48Autoimmune hemolytic anemia (HP:0001890)2.15329162
49Medial flaring of the eyebrow (HP:0010747)2.14958730
50Alveolar cell carcinoma (HP:0006519)2.14916516
51Hemiplegia (HP:0002301)2.14136819
52Recurrent bacterial skin infections (HP:0005406)2.12958517
53Cystic liver disease (HP:0006706)2.12287677
54Bile duct proliferation (HP:0001408)2.11601145
55Abnormal biliary tract physiology (HP:0012439)2.11601145
56Abnormality of B cell number (HP:0010975)2.11597393
57Increased corneal curvature (HP:0100692)2.08937492
58Keratoconus (HP:0000563)2.08937492
59Granulocytopenia (HP:0001913)2.07786932
60Fair hair (HP:0002286)2.07345672
61Type II lissencephaly (HP:0007260)2.06358348
62Hemoptysis (HP:0002105)2.04600365
63Keratoconjunctivitis (HP:0001096)2.04037797
64Abnormal drinking behavior (HP:0030082)2.03645412
65Polydipsia (HP:0001959)2.03645412
66Abnormality of the prostate (HP:0008775)2.02923281
67Neoplasm of the tracheobronchial system (HP:0100552)2.00556993
68Meningitis (HP:0001287)2.00113363
69Widely spaced teeth (HP:0000687)1.99830069
70Agammaglobulinemia (HP:0004432)1.98229963
71Recurrent abscess formation (HP:0002722)1.94644441
72Vasculitis (HP:0002633)1.90822710
73Pulmonary infiltrates (HP:0002113)1.90242287
74Recurrent skin infections (HP:0001581)1.90158534
75Focal motor seizures (HP:0011153)1.88431830
76Decreased circulating renin level (HP:0003351)1.86439318
77Autoimmune thrombocytopenia (HP:0001973)1.85257530
78Chest pain (HP:0100749)1.84540486
79Asplenia (HP:0001746)1.82515356
80Eczematoid dermatitis (HP:0000976)1.82121776
81Gaze-evoked nystagmus (HP:0000640)1.80854334
82Increased IgM level (HP:0003496)1.80331290
83Gastrointestinal infarctions (HP:0005244)1.80250149
84IgM deficiency (HP:0002850)1.78839754
85Aplasia/Hypoplasia of the spleen (HP:0010451)1.78746779
86Hematochezia (HP:0002573)1.76601870
87Keratoconjunctivitis sicca (HP:0001097)1.75956835
88Anencephaly (HP:0002323)1.75816939
89Recurrent bronchitis (HP:0002837)1.75403272
90Anhidrosis (HP:0000970)1.74690675
91Clumsiness (HP:0002312)1.71964282
92Keratitis (HP:0000491)1.71906753
93Neoplasm of the adrenal cortex (HP:0100641)1.71083033
94Hemiparesis (HP:0001269)1.68463376
95Mediastinal lymphadenopathy (HP:0100721)1.68374142
96Generalized hypopigmentation of hair (HP:0011358)1.67051543
97Congenital hepatic fibrosis (HP:0002612)1.65728791
98Absent speech (HP:0001344)1.65603555
99Chronic otitis media (HP:0000389)1.63659302
100Progressive cerebellar ataxia (HP:0002073)1.62877901

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.39877016
2TXK3.69470719
3MAP4K13.06097308
4TAOK32.63629407
5ZAK2.45674877
6ADRBK22.29778137
7TEC2.20363582
8ITK2.16975067
9NUAK12.09468753
10FES2.09081284
11BMPR1B1.91537069
12IKBKB1.84644876
13GRK11.82028221
14NLK1.79442055
15IKBKE1.65403205
16ACVR1B1.64439856
17TNK21.54270985
18TLK11.53768735
19TRIM281.51691107
20BTK1.50496810
21MUSK1.50334749
22MAP4K21.47688100
23SYK1.46066046
24TNIK1.44219257
25KIT1.42586682
26MAPK131.33815026
27SIK21.30954972
28GRK61.25217736
29PRKCQ1.22022440
30SIK31.20032899
31JAK31.19996844
32MAP3K41.18506232
33TYK21.17884801
34LYN1.17012245
35LCK1.16423952
36TGFBR11.13665723
37WNK31.12311164
38MARK31.07335958
39MAP3K141.03176313
40PINK11.01978502
41IRAK11.00821493
42WNK41.00506434
43BCKDK0.99636494
44HCK0.99039471
45CAMKK20.97971326
46INSRR0.97347764
47IRAK40.95723613
48PIK3CG0.95597811
49EPHA30.95372429
50DYRK20.94040818
51ZAP700.93930867
52JAK10.91694984
53FGFR30.90950900
54CSF1R0.88837125
55CHUK0.87071236
56CSK0.86696375
57GRK50.82205306
58DAPK20.79586566
59BMPR20.78700594
60RIPK40.77254693
61ADRBK10.72922365
62MST40.72326302
63TIE10.67894846
64FGFR20.63918978
65GRK70.61977210
66STK110.61538391
67NTRK20.57029407
68PAK30.55111540
69BLK0.54622782
70TGFBR20.54306815
71PIM10.53968096
72MAP3K130.53281276
73TBK10.52965851
74MAP2K20.49943290
75MAP2K60.49467759
76OXSR10.49288956
77PASK0.48883050
78MAPK70.47960747
79HIPK20.46910374
80RPS6KA60.46498788
81TRPM70.45728493
82CAMK10.44788616
83ABL10.44335196
84VRK10.41698963
85MKNK20.40864600
86PRKCZ0.40860766
87JAK20.40354389
88CAMK40.40173918
89KDR0.39700921
90CAMKK10.39597128
91SGK20.38582812
92ERBB30.38257527
93VRK20.37528212
94MAP3K70.37350419
95DYRK1A0.37344043
96WNK10.36938260
97PRKCE0.36209677
98EPHB10.35456597
99MAPKAPK30.34968512
100SGK2230.34279580

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.51629677
2Graft-versus-host disease_Homo sapiens_hsa053323.36540926
3Allograft rejection_Homo sapiens_hsa053302.82702017
4Autoimmune thyroid disease_Homo sapiens_hsa053202.70355223
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.63200979
6Phototransduction_Homo sapiens_hsa047442.28313853
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.22823588
8Asthma_Homo sapiens_hsa053102.21457316
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.18725325
10Type I diabetes mellitus_Homo sapiens_hsa049402.14422260
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.99386984
12Linoleic acid metabolism_Homo sapiens_hsa005911.95966080
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.93317425
14Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.85135514
15T cell receptor signaling pathway_Homo sapiens_hsa046601.75895881
16NOD-like receptor signaling pathway_Homo sapiens_hsa046211.69301220
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.65903773
18Staphylococcus aureus infection_Homo sapiens_hsa051501.65659825
19Hematopoietic cell lineage_Homo sapiens_hsa046401.50418970
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.45711975
21Antigen processing and presentation_Homo sapiens_hsa046121.45652242
22NF-kappa B signaling pathway_Homo sapiens_hsa040641.44495885
23Ether lipid metabolism_Homo sapiens_hsa005651.43975919
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.37047767
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.33797539
26Nitrogen metabolism_Homo sapiens_hsa009101.30418817
27Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.28508736
28Jak-STAT signaling pathway_Homo sapiens_hsa046301.24906671
29Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.18749384
30Leishmaniasis_Homo sapiens_hsa051401.14612678
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.14077058
32Measles_Homo sapiens_hsa051621.10994764
33Caffeine metabolism_Homo sapiens_hsa002321.10364674
34Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.05396479
35B cell receptor signaling pathway_Homo sapiens_hsa046621.03408030
36Osteoclast differentiation_Homo sapiens_hsa043801.03225502
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.01589203
38RNA polymerase_Homo sapiens_hsa030201.01564500
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.01403687
40Morphine addiction_Homo sapiens_hsa050321.00991204
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.95505595
42Olfactory transduction_Homo sapiens_hsa047400.94075940
43Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.92881100
44Dorso-ventral axis formation_Homo sapiens_hsa043200.92419726
45Chemokine signaling pathway_Homo sapiens_hsa040620.89607915
46RNA degradation_Homo sapiens_hsa030180.88829805
47Rheumatoid arthritis_Homo sapiens_hsa053230.87553844
48Butanoate metabolism_Homo sapiens_hsa006500.87469498
49Herpes simplex infection_Homo sapiens_hsa051680.84785740
50African trypanosomiasis_Homo sapiens_hsa051430.82198981
51Homologous recombination_Homo sapiens_hsa034400.82156470
52Peroxisome_Homo sapiens_hsa041460.81276787
53ABC transporters_Homo sapiens_hsa020100.80501068
54Arachidonic acid metabolism_Homo sapiens_hsa005900.80033461
55Viral myocarditis_Homo sapiens_hsa054160.77620442
56Taste transduction_Homo sapiens_hsa047420.75836318
57Platelet activation_Homo sapiens_hsa046110.75708150
58Glycerolipid metabolism_Homo sapiens_hsa005610.74940444
59Tuberculosis_Homo sapiens_hsa051520.71399004
60Fanconi anemia pathway_Homo sapiens_hsa034600.62811977
61Tryptophan metabolism_Homo sapiens_hsa003800.62707971
62Circadian entrainment_Homo sapiens_hsa047130.62325074
63Regulation of autophagy_Homo sapiens_hsa041400.60519175
64TNF signaling pathway_Homo sapiens_hsa046680.60477455
65Selenocompound metabolism_Homo sapiens_hsa004500.59519875
66Glycerophospholipid metabolism_Homo sapiens_hsa005640.58318716
67Nicotine addiction_Homo sapiens_hsa050330.57499942
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.56121862
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55720247
70Chemical carcinogenesis_Homo sapiens_hsa052040.54592847
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53345773
72Serotonergic synapse_Homo sapiens_hsa047260.52798638
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50594733
74Toll-like receptor signaling pathway_Homo sapiens_hsa046200.49626550
75Calcium signaling pathway_Homo sapiens_hsa040200.49209996
76Malaria_Homo sapiens_hsa051440.48786181
77Salivary secretion_Homo sapiens_hsa049700.48765717
78Influenza A_Homo sapiens_hsa051640.48330502
79Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47583078
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.46956203
81Glutamatergic synapse_Homo sapiens_hsa047240.46594531
82Toxoplasmosis_Homo sapiens_hsa051450.45895176
83Retinol metabolism_Homo sapiens_hsa008300.45098409
84Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44922021
85Cholinergic synapse_Homo sapiens_hsa047250.44606284
86Acute myeloid leukemia_Homo sapiens_hsa052210.44252926
87Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.43914249
88Propanoate metabolism_Homo sapiens_hsa006400.43615917
89Ovarian steroidogenesis_Homo sapiens_hsa049130.43279870
90Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.43232039
91Long-term depression_Homo sapiens_hsa047300.43228942
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.42737423
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42390906
94Ribosome_Homo sapiens_hsa030100.41703327
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41119851
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.39651790
97Oxytocin signaling pathway_Homo sapiens_hsa049210.36603594
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34826057
99FoxO signaling pathway_Homo sapiens_hsa040680.33657985
100Oxidative phosphorylation_Homo sapiens_hsa001900.33612546

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