PRM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1multicellular organism reproduction (GO:0032504)9.66865686
2motile cilium assembly (GO:0044458)9.06559116
3plasma membrane fusion (GO:0045026)9.05738789
4epithelial cilium movement (GO:0003351)9.02448359
5response to pheromone (GO:0019236)8.75547805
6reproduction (GO:0000003)8.75177937
7axonemal dynein complex assembly (GO:0070286)8.74343960
8regulation of cilium movement (GO:0003352)8.42405030
9negative regulation of inclusion body assembly (GO:0090084)8.32992057
10organic cation transport (GO:0015695)7.59749730
11rRNA methylation (GO:0031167)7.44082564
12protein targeting to Golgi (GO:0000042)7.35389222
13* spermatogenesis (GO:0007283)7.21425573
14* male gamete generation (GO:0048232)7.18724366
15cilium movement (GO:0003341)7.14297386
16sperm capacitation (GO:0048240)7.09733716
17establishment of protein localization to Golgi (GO:0072600)7.04572357
18synaptonemal complex organization (GO:0070193)6.90894995
19synaptonemal complex assembly (GO:0007130)6.88510582
20single fertilization (GO:0007338)6.87053677
21retrograde transport, vesicle recycling within Golgi (GO:0000301)6.86037494
22regulation of inclusion body assembly (GO:0090083)6.85833268
23microtubule depolymerization (GO:0007019)6.65264456
24* gamete generation (GO:0007276)6.59522743
25phosphatidylethanolamine biosynthetic process (GO:0006646)6.53846514
26cilium or flagellum-dependent cell motility (GO:0001539)6.40819179
27epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.35139930
28rRNA modification (GO:0000154)6.27413231
29male meiosis (GO:0007140)6.21892865
30calcium ion-dependent exocytosis (GO:0017156)6.08758089
31phosphatidylethanolamine metabolic process (GO:0046337)6.03436661
32fertilization (GO:0009566)5.98187141
33centriole replication (GO:0007099)5.84981219
34* chromosome condensation (GO:0030261)5.84070423
35piRNA metabolic process (GO:0034587)5.77478353
36spermatid nucleus differentiation (GO:0007289)5.73649318
37* DNA packaging (GO:0006323)5.71517021
38germ cell development (GO:0007281)5.60165751
39glycerol ether metabolic process (GO:0006662)5.58050562
40sexual reproduction (GO:0019953)5.54270815
41cellular process involved in reproduction in multicellular organism (GO:0022412)5.46307855
42cellular ketone body metabolic process (GO:0046950)5.30557777
43protein localization to Golgi apparatus (GO:0034067)5.27574095
44centriole assembly (GO:0098534)5.20140554
45* multicellular organismal reproductive process (GO:0048609)5.17068447
46ether metabolic process (GO:0018904)5.15554670
47cell recognition (GO:0008037)5.11721355
48regulation of microtubule-based movement (GO:0060632)4.99498625
49regulation of Rab GTPase activity (GO:0032313)4.98910838
50positive regulation of Rab GTPase activity (GO:0032851)4.98910838
51single strand break repair (GO:0000012)4.92097003
52seminiferous tubule development (GO:0072520)4.91400152
53regulation of centriole replication (GO:0046599)4.88486856
54microtubule severing (GO:0051013)4.86676895
55sequestering of actin monomers (GO:0042989)4.81672573
56antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.78344997
57ventricular system development (GO:0021591)4.73771709
58ketone body metabolic process (GO:1902224)4.67924440
59chromosome organization involved in meiosis (GO:0070192)4.51657703
60chaperone-mediated protein complex assembly (GO:0051131)4.48457398
61male meiosis I (GO:0007141)4.38420076
62regulation of transcription involved in cell fate commitment (GO:0060850)4.33914925
63* multicellular organismal development (GO:0007275)4.16201707
64left/right pattern formation (GO:0060972)4.14578016
65glomerular visceral epithelial cell development (GO:0072015)3.92129041
66multicellular organismal movement (GO:0050879)3.91158407
67musculoskeletal movement (GO:0050881)3.91158407
68negative regulation of Rho protein signal transduction (GO:0035024)3.83338776
69meiotic nuclear division (GO:0007126)3.81378484
70DNA methylation involved in gamete generation (GO:0043046)3.80440138
71glomerular epithelial cell development (GO:0072310)3.75251346
72coenzyme catabolic process (GO:0009109)3.73203952
73polyamine biosynthetic process (GO:0006596)3.69240349
74positive regulation of macrophage activation (GO:0043032)3.69036935
75microtubule nucleation (GO:0007020)3.57478697
76RNA destabilization (GO:0050779)3.57169800
77regulation of spindle checkpoint (GO:0090231)3.55272209
78protein refolding (GO:0042026)3.48722095
79meiosis I (GO:0007127)3.47858896
80protein polyglutamylation (GO:0018095)3.47220535
81RNA localization (GO:0006403)3.46104444
82interferon-gamma secretion (GO:0072643)3.44918621
83chromatin silencing (GO:0006342)3.42913864
84regulation of somitogenesis (GO:0014807)3.39702476
85nucleus organization (GO:0006997)3.38155759
86microtubule polymerization or depolymerization (GO:0031109)3.38125123
87protein K11-linked deubiquitination (GO:0035871)3.36428189
88genitalia morphogenesis (GO:0035112)3.35747534
89cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.30049227
90regulation of interleukin-13 production (GO:0032656)3.29642703
91glycolytic process (GO:0006096)3.27944492
92response to acidic pH (GO:0010447)3.27292490
93histone H3-K9 demethylation (GO:0033169)3.25027881
94amino-acid betaine transport (GO:0015838)3.20095313
95carnitine transport (GO:0015879)3.20095313
96mitotic sister chromatid cohesion (GO:0007064)3.17902452
97cellular response to pH (GO:0071467)3.16975465
98homeostasis of number of cells within a tissue (GO:0048873)3.16583033
99protein depolymerization (GO:0051261)3.16096225
100regulation of T-helper 2 cell differentiation (GO:0045628)3.15388969
101cerebral cortex neuron differentiation (GO:0021895)3.15333811
102mitochondrion degradation (GO:0000422)3.06966758
103peptidyl-threonine dephosphorylation (GO:0035970)3.04101138
104meiotic cell cycle (GO:0051321)2.99603234
105membrane protein intracellular domain proteolysis (GO:0031293)2.98364687
106carnitine transmembrane transport (GO:1902603)2.97495820
107cranial nerve morphogenesis (GO:0021602)2.95511362
108nucleoside diphosphate phosphorylation (GO:0006165)2.92927007
109regulation of phosphoprotein phosphatase activity (GO:0043666)2.89697814
110regulation of cilium assembly (GO:1902017)2.89616868
111mesenchymal cell differentiation involved in renal system development (GO:2001012)2.87158332
112mesenchymal cell differentiation involved in kidney development (GO:0072161)2.87158332
113protein-DNA complex disassembly (GO:0032986)2.86396000
114nucleosome disassembly (GO:0006337)2.86396000
115mitotic G1 DNA damage checkpoint (GO:0031571)2.85159870
116nuclear pore complex assembly (GO:0051292)2.83709697
117receptor recycling (GO:0001881)2.82743532
118cell differentiation involved in metanephros development (GO:0072202)2.75849247
119polyol catabolic process (GO:0046174)2.73777907
120intra-Golgi vesicle-mediated transport (GO:0006891)2.72913456
121positive regulation of glycolytic process (GO:0045821)2.72465745
122negative regulation of histone methylation (GO:0031061)2.72310518
123protein localization to cilium (GO:0061512)2.71745213
124alditol metabolic process (GO:0019400)2.69280080
125negative regulation of gene expression, epigenetic (GO:0045814)2.62272775
126GTP biosynthetic process (GO:0006183)2.60560086
127meiotic cell cycle process (GO:1903046)2.57479202
128synapsis (GO:0007129)2.45365967
129cilium organization (GO:0044782)2.42568462
130peptidyl-glutamic acid modification (GO:0018200)2.41311328
131cellular biogenic amine biosynthetic process (GO:0042401)2.40786412
132amine biosynthetic process (GO:0009309)2.40786412
133cellular component assembly involved in morphogenesis (GO:0010927)2.40440033
134microtubule-based movement (GO:0007018)2.37207468
135monoubiquitinated protein deubiquitination (GO:0035520)2.35304080
136cilium morphogenesis (GO:0060271)2.34712739
137sperm motility (GO:0030317)14.7849144
138cell wall macromolecule catabolic process (GO:0016998)13.7340758
139cell wall macromolecule metabolic process (GO:0044036)13.7340758
140acrosome reaction (GO:0007340)13.4518127
141fusion of sperm to egg plasma membrane (GO:0007342)11.8946766
142sperm-egg recognition (GO:0035036)11.7166873
143acrosome assembly (GO:0001675)11.6294366
144binding of sperm to zona pellucida (GO:0007339)10.8513850
145cell-cell recognition (GO:0009988)10.4914790
146spermatid development (GO:0007286)10.1941828

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.49314979
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.63839823
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.53340354
4EZH2_22144423_ChIP-Seq_EOC_Human4.37917501
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.35609711
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.00663414
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.96469823
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.94542446
9VDR_22108803_ChIP-Seq_LS180_Human2.65283625
10GATA1_26923725_Chip-Seq_HPCs_Mouse2.54354405
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.28966061
12* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.25242109
13ZNF274_21170338_ChIP-Seq_K562_Hela2.10760134
14VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.10662202
15EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.07019153
16CTBP1_25329375_ChIP-Seq_LNCAP_Human2.05842954
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.98598664
18FUS_26573619_Chip-Seq_HEK293_Human1.96796237
19FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.92655459
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.92453672
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.91878868
22RAC3_21632823_ChIP-Seq_H3396_Human1.91510317
23DROSHA_22980978_ChIP-Seq_HELA_Human1.87731616
24* ERA_21632823_ChIP-Seq_H3396_Human1.84258228
25SOX2_22085726_ChIP-Seq_NPCs_Mouse1.83644298
26ELK4_26923725_Chip-Seq_MESODERM_Mouse1.83286661
27EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.76037297
28MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.75638351
29KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.75541675
30GATA3_21867929_ChIP-Seq_CD8_Mouse1.72403625
31UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.67732965
32STAT1_17558387_ChIP-Seq_HELA_Human1.67596160
33TAF2_19829295_ChIP-Seq_ESCs_Human1.62207457
34TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.60827259
35MYC_19829295_ChIP-Seq_ESCs_Human1.58841082
36* FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.57354126
37TDRD3_21172665_ChIP-Seq_MCF-7_Human1.56295072
38ER_23166858_ChIP-Seq_MCF-7_Human1.55851041
39ARNT_22903824_ChIP-Seq_MCF-7_Human1.55389471
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.53466971
41E2F1_20622854_ChIP-Seq_HELA_Human1.52507824
42SMAD4_21741376_ChIP-Seq_EPCs_Human1.50110495
43P68_20966046_ChIP-Seq_HELA_Human1.49016684
44GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.48492027
45AUTS2_25519132_ChIP-Seq_293T-REX_Human1.47518946
46* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.47187020
47* SMC4_20622854_ChIP-Seq_HELA_Human1.47104433
48PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.46030488
49P53_21459846_ChIP-Seq_SAOS-2_Human1.46024565
50CBX2_22325352_ChIP-Seq_293T-Rex_Human1.42942362
51OCT4_20526341_ChIP-Seq_ESCs_Human1.42857585
52HNFA_21074721_ChIP-Seq_CACO-2_Human1.42401813
53* TP63_22573176_ChIP-Seq_HFKS_Human1.42362382
54TP53_18474530_ChIP-ChIP_U2OS_Human1.41154176
55RBPJ_21746931_ChIP-Seq_IB4_Human1.40353680
56WDR5_24793694_ChIP-Seq_LNCAP_Human1.39825752
57LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.39586267
58PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.38994547
59SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.38290846
60CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.38101656
61AR_25329375_ChIP-Seq_VCAP_Human1.37811143
62LXR_22292898_ChIP-Seq_THP-1_Human1.37700224
63TET1_21451524_ChIP-Seq_MESCs_Mouse1.37688215
64RAD21_21589869_ChIP-Seq_MESCs_Mouse1.34801995
65SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34766544
66KDM2B_26808549_Chip-Seq_REH_Human1.34329771
67CBP_20019798_ChIP-Seq_JUKART_Human1.34249215
68IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34249215
69CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33910928
70ETV1_20927104_ChIP-Seq_GIST48_Human1.32483205
71* REST_21632747_ChIP-Seq_MESCs_Mouse1.32372874
72P300_27268052_Chip-Seq_Bcells_Human1.30164102
73SMAD3_21741376_ChIP-Seq_ESCs_Human1.28781995
74TP63_19390658_ChIP-ChIP_HaCaT_Human1.28771496
75TAL1_26923725_Chip-Seq_HPCs_Mouse1.28502465
76SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.28393444
77GF1_26923725_Chip-Seq_HPCs_Mouse1.28268471
78CEBPB_22108803_ChIP-Seq_LS180_Human1.28222268
79SMAD3_21741376_ChIP-Seq_EPCs_Human1.28193927
80RXRA_24833708_ChIP-Seq_LIVER_Mouse1.26158417
81JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.25582827
82ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.25153087
83* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24638761
84MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.24607813
85MYC_27129775_Chip-Seq_CORNEA_Mouse1.24460175
86CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.23795313
87TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23617129
88NFYB_21822215_ChIP-Seq_K562_Human1.23548975
89SPI1_26923725_Chip-Seq_HPCs_Mouse1.23171295
90GATA3_21867929_ChIP-Seq_TH1_Mouse1.23071106
91P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.22248544
92GATA1_19941827_ChIP-Seq_MEL86_Mouse1.21866543
93P300_19829295_ChIP-Seq_ESCs_Human1.21860778
94GATA3_21878914_ChIP-Seq_MCF-7_Human1.21597398
95MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.20968055
96PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20650040
97TBL1_22424771_ChIP-Seq_293T_Human1.20479279
98CTCF_20526341_ChIP-Seq_ESCs_Human1.19480424
99RUNX_20019798_ChIP-Seq_JUKART_Human1.18055432
100TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17933328
101RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.17162222
102RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.16768657
103ERG_20517297_ChIP-Seq_VCAP_Human1.15993216
104FLI1_21867929_ChIP-Seq_TH2_Mouse1.14953357
105RARA_24833708_ChIP-Seq_LIVER_Mouse1.14877169
106BCOR_27268052_Chip-Seq_Bcells_Human1.14667110
107PHF8_20622853_ChIP-Seq_HELA_Human1.14491036
108TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14440819
109SA1_27219007_Chip-Seq_Bcells_Human1.14426239
110YY1_22570637_ChIP-Seq_MALME-3M_Human1.13958046
111SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13560912
112CTBP2_25329375_ChIP-Seq_LNCAP_Human1.13304711
113TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13218876
114POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13218876
115GATA6_21074721_ChIP-Seq_CACO-2_Human1.12800316
116PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12527506
117PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.12516864
118NFIB_24661679_ChIP-Seq_LUNG_Mouse1.12237553
119SMAD4_21741376_ChIP-Seq_HESCs_Human1.11716625
120SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.11025589
121SRY_22984422_ChIP-ChIP_TESTIS_Rat1.10856870
122ESET_19884257_ChIP-Seq_ESCs_Mouse1.10350273
123SMRT_27268052_Chip-Seq_Bcells_Human1.09465744
124ELF1_20517297_ChIP-Seq_JURKAT_Human1.08051409
125SOX11_22085726_ChIP-Seq_ESNs_Mouse1.07562482
126KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07195267
127SMC3_22415368_ChIP-Seq_MEFs_Mouse1.06719739
128TAF15_26573619_Chip-Seq_HEK293_Human1.05951236
129KAP1_22055183_ChIP-Seq_ESCs_Mouse1.05769610
130EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.05369699
131PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.05032353
132RUNX1_26923725_Chip-Seq_HPCs_Mouse1.03629191
133GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.03596635
134PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.03543352
135EZH2_27294783_Chip-Seq_ESCs_Mouse1.03508885
136RUNX2_22187159_ChIP-Seq_PCA_Human1.02925208
137EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02539875
138RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.02393869
139ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.02312917
140LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.02190254
141NFYA_21822215_ChIP-Seq_K562_Human1.02059915
142NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.01563315
143ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.00462318
144CTCF_27219007_Chip-Seq_Bcells_Human0.99671883
145SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99268146
146SOX2_19829295_ChIP-Seq_ESCs_Human0.98571112
147NANOG_19829295_ChIP-Seq_ESCs_Human0.98571112
148TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98187193
149KLF5_25053715_ChIP-Seq_YYC3_Human0.97399577
150TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97251308
151E2F1_17053090_ChIP-ChIP_MCF-7_Human0.97155184
152SA1_27219007_Chip-Seq_ERYTHROID_Human0.97041579
153FLI1_21867929_ChIP-Seq_CD8_Mouse0.96100209
154CBX2_27304074_Chip-Seq_ESCs_Mouse0.94423627
155* BCL6_27268052_Chip-Seq_Bcells_Human0.93703123
156ETV2_25802403_ChIP-Seq_MESCs_Mouse0.93535482
157NFE2_27457419_Chip-Seq_LIVER_Mouse0.93214311
158PHF8_20622854_ChIP-Seq_HELA_Human0.92869324
159CSB_26484114_Chip-Seq_FIBROBLAST_Human0.91118719
160PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90538438
161NANOG_20526341_ChIP-Seq_ESCs_Human0.90441227
162SOX2_21211035_ChIP-Seq_LN229_Human0.88184430
163KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.88178118
164* SUZ12_27294783_Chip-Seq_ESCs_Mouse0.87555976
165LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.87093846
166NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.86448952

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.12724497
2MP0001929_abnormal_gametogenesis5.62334123
3MP0005670_abnormal_white_adipose3.41715826
4MP0008877_abnormal_DNA_methylation3.39005640
5MP0002161_abnormal_fertility/fecundity3.34382481
6MP0002210_abnormal_sex_determination3.15701090
7MP0001145_abnormal_male_reproductive2.70737582
8MP0000678_abnormal_parathyroid_gland2.58807585
9MP0000653_abnormal_sex_gland2.32049067
10MP0003718_maternal_effect2.28836479
11MP0002132_abnormal_respiratory_system2.02115395
12* MP0005410_abnormal_fertilization16.8026633
13MP0005379_endocrine/exocrine_gland_phen1.82371140
14MP0003646_muscle_fatigue1.79055824
15MP0005423_abnormal_somatic_nervous1.76868487
16MP0004233_abnormal_muscle_weight1.76656941
17MP0001485_abnormal_pinna_reflex1.67938016
18MP0005310_abnormal_salivary_gland1.63331719
19MP0002249_abnormal_larynx_morphology1.60809421
20MP0002653_abnormal_ependyma_morphology1.59285925
21MP0001486_abnormal_startle_reflex1.54084404
22MP0002160_abnormal_reproductive_system1.48657921
23MP0005451_abnormal_body_composition1.44718281
24MP0009053_abnormal_anal_canal1.42902236
25MP0004510_myositis1.37070160
26MP0002234_abnormal_pharynx_morphology1.27087389
27MP0004859_abnormal_synaptic_plasticity1.21968177
28MP0002138_abnormal_hepatobiliary_system1.16888013
29MP0001963_abnormal_hearing_physiology1.13241050
30MP0002127_abnormal_cardiovascular_syste1.12704695
31MP0002735_abnormal_chemical_nociception1.11719735
32MP0005248_abnormal_Harderian_gland1.11474336
33MP0001984_abnormal_olfaction1.09380495
34MP0001765_abnormal_ion_homeostasis1.07331497
35MP0005395_other_phenotype1.04323831
36MP0005623_abnormal_meninges_morphology1.01475021
37MP0000026_abnormal_inner_ear0.98012915
38MP0000681_abnormal_thyroid_gland0.86695141
39MP0000955_abnormal_spinal_cord0.86432728
40MP0002282_abnormal_trachea_morphology0.84031506
41MP0003329_amyloid_beta_deposits0.75820672
42MP0003115_abnormal_respiratory_system0.75498663
43MP0000049_abnormal_middle_ear0.73674729
44MP0002067_abnormal_sensory_capabilities0.73335947
45MP0005083_abnormal_biliary_tract0.72114307
46MP0004085_abnormal_heartbeat0.69536710
47MP0001879_abnormal_lymphatic_vessel0.69113001
48MP0005389_reproductive_system_phenotype0.68805351
49MP0005367_renal/urinary_system_phenotyp0.67228832
50MP0000516_abnormal_urinary_system0.67228832
51MP0005647_abnormal_sex_gland0.66868864
52MP0005666_abnormal_adipose_tissue0.66542458
53MP0002557_abnormal_social/conspecific_i0.65821909
54MP0002733_abnormal_thermal_nociception0.65303863
55MP0002736_abnormal_nociception_after0.64718415
56MP0005636_abnormal_mineral_homeostasis0.63566045
57MP0005167_abnormal_blood-brain_barrier0.63169017
58MP0003011_delayed_dark_adaptation0.63041562
59MP0004036_abnormal_muscle_relaxation0.62560061
60MP0009697_abnormal_copulation0.62518473
61MP0001666_abnormal_nutrient_absorption0.58744045
62MP0006036_abnormal_mitochondrial_physio0.56921469
63MP0002269_muscular_atrophy0.56879435
64MP0004484_altered_response_of0.56222261
65MP0000534_abnormal_ureter_morphology0.55406276
66MP0003077_abnormal_cell_cycle0.55405015
67MP0009046_muscle_twitch0.55390044
68MP0000003_abnormal_adipose_tissue0.55087717
69MP0001905_abnormal_dopamine_level0.52780126
70MP0002572_abnormal_emotion/affect_behav0.52131722
71MP0001764_abnormal_homeostasis0.51040298
72MP0003137_abnormal_impulse_conducting0.49776179
73MP0008058_abnormal_DNA_repair0.48047835
74MP0008995_early_reproductive_senescence0.47039359
75MP0001324_abnormal_eye_pigmentation0.46456638
76MP0008961_abnormal_basal_metabolism0.45473372
77MP0005535_abnormal_body_temperature0.45281411
78MP0000249_abnormal_blood_vessel0.45239000
79MP0005397_hematopoietic_system_phenotyp0.43908484
80MP0001545_abnormal_hematopoietic_system0.43908484
81MP0002139_abnormal_hepatobiliary_system0.43891084
82MP0003878_abnormal_ear_physiology0.43153909
83MP0005377_hearing/vestibular/ear_phenot0.43153909
84MP0009278_abnormal_bone_marrow0.42277050
85MP0001970_abnormal_pain_threshold0.42172409
86MP0000604_amyloidosis0.41972434
87MP0001440_abnormal_grooming_behavior0.41908181
88MP0005408_hypopigmentation0.41600017
89MP0000358_abnormal_cell_content/0.41535902
90MP0002734_abnormal_mechanical_nocicepti0.41318532
91MP0003699_abnormal_female_reproductive0.41106604
92MP0000613_abnormal_salivary_gland0.41053104
93MP0001501_abnormal_sleep_pattern0.39674270
94MP0000230_abnormal_systemic_arterial0.39649970
95MP0001293_anophthalmia0.38987807
96MP0001968_abnormal_touch/_nociception0.38898193
97MP0009745_abnormal_behavioral_response0.38864204
98MP0005084_abnormal_gallbladder_morpholo0.38020146
99MP0003942_abnormal_urinary_system0.37541441
100MP0004133_heterotaxia0.37483889
101MP0004811_abnormal_neuron_physiology0.36860409
102MP0003119_abnormal_digestive_system0.36245133
103MP0000566_synostosis0.35862839
104MP0009115_abnormal_fat_cell0.35581306
105MP0000470_abnormal_stomach_morphology0.35419963
106MP0003880_abnormal_central_pattern0.33555975
107MP0001270_distended_abdomen0.33230317
108MP0003936_abnormal_reproductive_system0.32914689
109MP0005253_abnormal_eye_physiology0.32615854
110MP0003633_abnormal_nervous_system0.30072719
111MP0002928_abnormal_bile_duct0.29072518
112MP0004270_analgesia0.28767222
113MP0005551_abnormal_eye_electrophysiolog0.28668993
114MP0002169_no_abnormal_phenotype0.28458813
115MP0002873_normal_phenotype0.28262393
116MP0000569_abnormal_digit_pigmentation0.28249738
117MP0002909_abnormal_adrenal_gland0.27686488
118MP0001730_embryonic_growth_arrest0.27078419
119MP0001849_ear_inflammation0.26099481
120MP0003948_abnormal_gas_homeostasis0.26025458
121MP0003879_abnormal_hair_cell0.25775640
122MP0006035_abnormal_mitochondrial_morpho0.25565159
123MP0003631_nervous_system_phenotype0.24928173
124MP0005391_vision/eye_phenotype0.24864898
125MP0003787_abnormal_imprinting0.24234353
126MP0003861_abnormal_nervous_system0.24108414
127MP0002152_abnormal_brain_morphology0.23428547
128MP0002971_abnormal_brown_adipose0.23317062
129MP0002295_abnormal_pulmonary_circulatio0.23114335
130MP0008875_abnormal_xenobiotic_pharmacok0.22625497
131MP0005375_adipose_tissue_phenotype0.22421762
132MP0003806_abnormal_nucleotide_metabolis0.22373964
133MP0000751_myopathy0.22293833
134MP0004145_abnormal_muscle_electrophysio0.21093491
135MP0000462_abnormal_digestive_system0.20923284
136MP0004043_abnormal_pH_regulation0.20396408
137MP0005365_abnormal_bile_salt0.20127454
138MP0008569_lethality_at_weaning0.19209471
139MP0003950_abnormal_plasma_membrane0.19168651
140MP0004742_abnormal_vestibular_system0.18217011
141MP0001661_extended_life_span0.18134789
142MP0002822_catalepsy0.17931686
143MP0003959_abnormal_lean_body0.17471161
144MP0002118_abnormal_lipid_homeostasis0.16339098
145MP0000001_mammalian_phenotype0.16162171
146MP0005319_abnormal_enzyme/_coenzyme0.16109720
147MP0004019_abnormal_vitamin_homeostasis0.15567389
148MP0000920_abnormal_myelination0.15066057
149MP0008770_decreased_survivor_rate0.15033351
150MP0003111_abnormal_nucleus_morphology0.15012420
151MP0001348_abnormal_lacrimal_gland0.14900504
152MP0004087_abnormal_muscle_fiber0.14712900
153MP0005360_urolithiasis0.14486357
154MP0002693_abnormal_pancreas_physiology0.14418178
155MP0002272_abnormal_nervous_system0.14385205
156MP0002106_abnormal_muscle_physiology0.14360196
157MP0002229_neurodegeneration0.14038257
158MP0010329_abnormal_lipoprotein_level0.13699655

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.21690408
2Abnormal respiratory epithelium morphology (HP:0012253)9.12363305
3Abnormal respiratory motile cilium morphology (HP:0005938)9.12363305
4Severe visual impairment (HP:0001141)8.06190265
5Infertility (HP:0000789)7.48636448
6Chronic bronchitis (HP:0004469)7.37830245
7Rhinitis (HP:0012384)7.27695927
8Abnormal ciliary motility (HP:0012262)6.99112985
9Nasal polyposis (HP:0100582)6.51869197
10Abnormality of the nasal mucosa (HP:0000433)5.37975340
11Male infertility (HP:0003251)5.22907076
12Chronic hepatic failure (HP:0100626)5.13625301
13Attenuation of retinal blood vessels (HP:0007843)4.81432889
14Bony spicule pigmentary retinopathy (HP:0007737)4.79642900
15Resting tremor (HP:0002322)4.73537426
16Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.55640523
17Hyperkalemia (HP:0002153)4.52307646
18Bronchitis (HP:0012387)4.49504153
19Bronchiectasis (HP:0002110)4.27761081
20Abnormality of macular pigmentation (HP:0008002)4.15817682
21Cone-rod dystrophy (HP:0000548)4.10701956
22Nephronophthisis (HP:0000090)3.90583343
23Abnormal spermatogenesis (HP:0008669)3.90536330
24Facial shape deformation (HP:0011334)3.79947605
25Potter facies (HP:0002009)3.79947605
26Aplasia/Hypoplasia of the earlobes (HP:0009906)3.76613188
27Abnormal rod and cone electroretinograms (HP:0008323)3.66690698
28Hypoplasia of the thymus (HP:0000778)3.42811174
29Hypoplastic ischia (HP:0003175)3.42561997
30Progressive sensorineural hearing impairment (HP:0000408)3.38914465
31Hypoalphalipoproteinemia (HP:0003233)3.35855503
32Enlarged epiphyses (HP:0010580)3.29491489
33Recurrent otitis media (HP:0000403)3.20174189
34Postural instability (HP:0002172)3.08165726
35Abnormality of the ischium (HP:0003174)3.06750986
36Amelogenesis imperfecta (HP:0000705)3.05821339
37Unilateral renal agenesis (HP:0000122)3.01216162
38Menstrual irregularities (HP:0000858)2.99057796
39Recurrent sinusitis (HP:0011108)2.98018372
40Abnormal gallbladder physiology (HP:0012438)2.94111282
41Cholecystitis (HP:0001082)2.94111282
42Abnormality of the renal medulla (HP:0100957)2.87557248
43Truncal obesity (HP:0001956)2.85411779
44Abnormality of the aortic arch (HP:0012303)2.79170047
45Renovascular hypertension (HP:0100817)2.79134078
46Progressive cerebellar ataxia (HP:0002073)2.76817511
47Abnormality of dental color (HP:0011073)2.75840348
48Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.71768005
49Insulin-resistant diabetes mellitus (HP:0000831)2.67717732
50Impulsivity (HP:0100710)2.67689930
51Tubular atrophy (HP:0000092)2.65951064
52Portal hypertension (HP:0001409)2.61670877
53Generalized aminoaciduria (HP:0002909)2.59126974
54Recurrent bronchitis (HP:0002837)2.57286758
55Abnormality of potassium homeostasis (HP:0011042)2.55538974
56Congenital malformation of the right heart (HP:0011723)2.54361516
57Double outlet right ventricle (HP:0001719)2.54361516
58Abnormality of the costochondral junction (HP:0000919)2.49726067
59Tubulointerstitial nephritis (HP:0001970)2.46901596
60Molar tooth sign on MRI (HP:0002419)2.43795962
61Abnormality of midbrain morphology (HP:0002418)2.43795962
62Ventricular tachycardia (HP:0004756)2.42741113
63Dyschromatopsia (HP:0007641)2.41314948
64Tubulointerstitial abnormality (HP:0001969)2.40284125
65Abnormality of the hepatic vasculature (HP:0006707)2.39450130
66Azoospermia (HP:0000027)2.38932088
67Choroideremia (HP:0001139)2.37648974
68Abnormality of the parathyroid morphology (HP:0011766)2.26875833
69Focal segmental glomerulosclerosis (HP:0000097)2.20216014
70Tubulointerstitial fibrosis (HP:0005576)2.17785104
71Progressive hearing impairment (HP:0001730)2.17698652
72Hyperuricemia (HP:0002149)2.16912151
73Increased purine levels (HP:0004368)2.16912151
74Flattened epiphyses (HP:0003071)2.16822879
75Osteomalacia (HP:0002749)2.16200877
76Medial flaring of the eyebrow (HP:0010747)2.11714405
77Decreased central vision (HP:0007663)2.10544164
78Neurofibrillary tangles (HP:0002185)2.10254082
79Hemorrhage of the eye (HP:0011885)2.06616832
80Myokymia (HP:0002411)2.04093883
81Gonadotropin excess (HP:0000837)2.04078405
82Hyponatremia (HP:0002902)2.02220340
83Absent/shortened dynein arms (HP:0200106)13.2006491
84Dynein arm defect of respiratory motile cilia (HP:0012255)13.2006491
85Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.5826472
86Intellectual disability, moderate (HP:0002342)1.98436656
87Spastic tetraparesis (HP:0001285)1.96377274
88Widely patent fontanelles and sutures (HP:0004492)1.93579015
89Epiphyseal dysplasia (HP:0002656)1.92939070
90Hypophosphatemic rickets (HP:0004912)1.92916409
91Tetany (HP:0001281)1.92381292
92Recurrent pneumonia (HP:0006532)1.90285186
93Bradycardia (HP:0001662)1.89811574
94Decreased electroretinogram (ERG) amplitude (HP:0000654)1.89542833
95Abnormality of the epiphysis of the femoral head (HP:0010574)1.89435056
96Subcapsular cataract (HP:0000523)1.89249351
97Exercise-induced myalgia (HP:0003738)1.87473321
98Polydipsia (HP:0001959)1.87273781
99Abnormal drinking behavior (HP:0030082)1.87273781
100Optic nerve hypoplasia (HP:0000609)1.81481524
101Renal Fanconi syndrome (HP:0001994)1.80995497
102Recurrent corneal erosions (HP:0000495)1.79581060
103Aplasia/Hypoplasia of the sacrum (HP:0008517)1.79323795
104Hyperthyroidism (HP:0000836)1.78027205
105Hypoparathyroidism (HP:0000829)1.76899818
106Abnormality of femoral epiphyses (HP:0006499)1.76099186
107Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.76099186
108Myoglobinuria (HP:0002913)1.72914450
109Cerebral inclusion bodies (HP:0100314)1.71951373
110Stage 5 chronic kidney disease (HP:0003774)1.69229139
111Abnormality of renal excretion (HP:0011036)1.68797640
112Easy fatigability (HP:0003388)1.62944200
113Sensory axonal neuropathy (HP:0003390)1.60575265
114Abnormal biliary tract physiology (HP:0012439)1.60274877
115Bile duct proliferation (HP:0001408)1.60274877
116Hypoplasia of the capital femoral epiphysis (HP:0003090)1.59001449
117Abnormality of the neuromuscular junction (HP:0003398)1.58017203
118Fatigable weakness (HP:0003473)1.58017203
119Heterotopia (HP:0002282)1.56839946
120Asymmetric septal hypertrophy (HP:0001670)1.56502803
121Aplasia/Hypoplasia of the lens (HP:0008063)1.54874552
122Rhabdomyolysis (HP:0003201)1.53906714
123Bundle branch block (HP:0011710)1.53273387
124Exercise-induced muscle cramps (HP:0003710)1.52693838
125Abnormal urine output (HP:0012590)1.52316116
126Loss of speech (HP:0002371)1.51746350
127Postaxial foot polydactyly (HP:0001830)1.50932019
128Hypercholesterolemia (HP:0003124)1.49288024
129Congenital hepatic fibrosis (HP:0002612)1.48800746
130Neoplasm of the heart (HP:0100544)1.46714965
131Abnormality of the renal cortex (HP:0011035)1.45624222
132Bell-shaped thorax (HP:0001591)1.42179287
133Oculomotor apraxia (HP:0000657)1.39986068
134Short ribs (HP:0000773)1.38153759
135Generalized muscle weakness (HP:0003324)1.35126942
136Constricted visual fields (HP:0001133)1.33914879
137Transposition of the great arteries (HP:0001669)1.33835926
138Abnormal connection of the cardiac segments (HP:0011545)1.33835926
139Abnormal ventriculo-arterial connection (HP:0011563)1.33835926
140Decreased muscle mass (HP:0003199)1.33045686
141Renal dysplasia (HP:0000110)1.31887883
142Cerebellar dysplasia (HP:0007033)1.29991072
143Deformed sella turcica (HP:0002681)1.25783434
144Type 2 muscle fiber atrophy (HP:0003554)1.25611802
145Aplasia/Hypoplasia affecting the retina (HP:0008061)1.24930478
146Bulbar palsy (HP:0001283)1.24741724
147Abnormality of dentin (HP:0010299)1.24694676
148Postaxial hand polydactyly (HP:0001162)1.24223684
149Absent epiphyses (HP:0010577)1.24149740
150Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.24149740
151Short femoral neck (HP:0100864)1.22827879
152Polyuria (HP:0000103)1.21573080
153Hemiparesis (HP:0001269)1.21427787
154Retinal dysplasia (HP:0007973)1.21281277
155Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.20661730
156Cleft eyelid (HP:0000625)1.19988133
157Global brain atrophy (HP:0002283)1.19184823
158Abnormality of the dental root (HP:0006486)1.17328861
159Taurodontia (HP:0000679)1.17328861
160Abnormality of permanent molar morphology (HP:0011071)1.17328861
161Facial cleft (HP:0002006)1.17078351
162Broad distal phalanx of finger (HP:0009836)1.16937102

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK48.97957578
2TESK17.83346967
3PDK47.13299627
4PDK37.13299627
5PRKD35.47774688
6ICK5.38263260
7PDK24.58904694
8DDR24.25682614
9INSRR4.04214202
10BRD43.67810795
11PLK23.33333725
12MAP4K23.26339401
13PTK2B2.29017617
14STK382.24992264
15WNK42.12421473
16STK392.07558507
17PIK3CG1.98773100
18DYRK1B1.86366499
19NEK21.63582463
20MST1R1.59047630
21CDK121.49288501
22PDK11.46613273
23PNCK1.33365352
24CDK71.21593736
25PDPK11.11727596
26RIPK41.05322857
27KSR21.03394475
28MAP3K90.97495787
29DYRK30.97102645
30AKT30.93941420
31CAMK1D0.92982883
32EEF2K0.89707206
33MAPK150.87718330
34IRAK10.87046326
35TYRO30.86911721
36LATS20.84775917
37MAP3K110.77648615
38WNK10.75405242
39PINK10.71897486
40SIK20.70476110
41TESK20.69201791
42CCNB10.67386174
43PASK0.66459993
44UHMK10.65621077
45RPS6KA20.62687935
46MAP2K20.62297597
47PRKAA20.60088386
48MUSK0.59486267
49MAP3K20.59148909
50NTRK20.58376319
51TTK0.58202055
52CAMK10.55404811
53IRAK20.55101077
54CHEK20.54566405
55STK30.52930450
56MAP3K100.52402814
57MAP3K80.50370287
58PRKCG0.49991770
59TIE10.48391632
60MAP2K60.48379259
61CDK30.48026851
62ROCK10.47992449
63SGK4940.46602731
64SGK2230.46602731
65LATS10.46557470
66PAK10.42464769
67MAPK10.40875605
68STK38L0.38705071
69BMPR1B0.37786725
70PAK40.36854988
71CAMK40.34981491
72MAPKAPK50.33896389
73PAK20.33832415
74CAMK1G0.33740430
75CAMKK10.31992215
76MARK20.31975563
77LMTK20.31869482
78RPS6KC10.30921745
79RPS6KL10.30921745
80NTRK30.30135216
81SGK10.29561681
82PRKCZ0.29097822
83ARAF0.28453115
84CHEK10.27862351
85RPS6KA60.27636699
86CDK150.24961978
87PRKCQ0.23252943
88MAPK140.22818067
89CDK180.21964018
90MTOR0.21614618
91MAPK100.20935475
92CDK11A0.20192720
93ATM0.18902054
94PRKAA10.18156339
95MAP3K40.18155336
96MET0.16888277
97PRKG20.16564134
98AKT10.16105230
99CDK140.15977374
100CSF1R0.15694503
101BRAF0.15675467
102BLK0.15457353
103RPS6KB10.13922206
104MAPK110.13837247
105RPS6KA10.12907423
106BRSK10.12168969
107SGK20.11790780
108STK100.11583673
109CLK10.11516828
110ATR0.11270289
111BRSK20.10710856
112OXSR10.10406232
113FER0.09961790
114PRKCD0.09387288
115NEK60.08438260
116TNIK0.07787442
117PIM10.06805872
118JAK30.06610428
119CSNK2A10.06553349
120MAPK90.06258382
121GSK3B0.06194464
122CAMK2A0.05639361
123TRIB30.05635986
124STK110.05269078
125PRKACG0.04029820
126PAK60.03993952
127CDK60.03802794
128MAP3K70.03719775
129PRKCA0.03461614
130CHUK0.03209162
131MARK30.03180911
132PRKCB0.03040161
133MAPK80.03013325
134SGK30.02940937
135PLK10.02737125
136EPHB10.02505378
137PRKG10.01475768
138PKN10.01219666
139MAP3K10.01029740
140CDK4-0.0657285
141CSK-0.0641909
142MAP3K5-0.0575661
143PRKACB-0.0540390
144IGF1R-0.0537881
145SRC-0.0503183
146MARK1-0.0473387
147PDGFRB-0.0329778
148CSNK1D-0.0327138
149PRKACA-0.0305665
150RPS6KA3-0.0257484
151EGFR-0.0218214
152CSNK2A2-0.0176157
153CDK1-0.0103078
154CDK2-0.0077993
155AURKA-0.0005116

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.61970989
2Fatty acid biosynthesis_Homo sapiens_hsa000615.23949804
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.40215063
4Olfactory transduction_Homo sapiens_hsa047403.71267876
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.44596273
6Linoleic acid metabolism_Homo sapiens_hsa005913.34032783
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.14386695
8Pyruvate metabolism_Homo sapiens_hsa006203.01336997
9Vitamin B6 metabolism_Homo sapiens_hsa007502.87401192
10Carbohydrate digestion and absorption_Homo sapiens_hsa049732.54718287
11Butanoate metabolism_Homo sapiens_hsa006502.52101366
12Glucagon signaling pathway_Homo sapiens_hsa049222.47111547
13Propanoate metabolism_Homo sapiens_hsa006402.26924855
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.24467656
15Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.05314204
16Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.98372501
17PPAR signaling pathway_Homo sapiens_hsa033201.91461465
18Glycerolipid metabolism_Homo sapiens_hsa005611.86059065
19Fat digestion and absorption_Homo sapiens_hsa049751.84914218
20Glycerophospholipid metabolism_Homo sapiens_hsa005641.82943495
21Selenocompound metabolism_Homo sapiens_hsa004501.81044847
22Basal transcription factors_Homo sapiens_hsa030221.78531926
23Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.76333069
24Type I diabetes mellitus_Homo sapiens_hsa049401.72453543
25Fatty acid degradation_Homo sapiens_hsa000711.68906110
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.67548457
27Allograft rejection_Homo sapiens_hsa053301.67053179
28Fatty acid metabolism_Homo sapiens_hsa012121.65439288
29Autoimmune thyroid disease_Homo sapiens_hsa053201.62912394
30Fructose and mannose metabolism_Homo sapiens_hsa000511.62443535
31Phenylalanine metabolism_Homo sapiens_hsa003601.62218436
32Amphetamine addiction_Homo sapiens_hsa050311.60651154
33Ether lipid metabolism_Homo sapiens_hsa005651.59028547
34Mineral absorption_Homo sapiens_hsa049781.57783660
35Graft-versus-host disease_Homo sapiens_hsa053321.50802817
36Cardiac muscle contraction_Homo sapiens_hsa042601.40346805
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.33437485
38Carbon metabolism_Homo sapiens_hsa012001.31583486
39Oocyte meiosis_Homo sapiens_hsa041141.30456060
40Pentose phosphate pathway_Homo sapiens_hsa000301.23627896
41Viral myocarditis_Homo sapiens_hsa054161.22816510
42Glutathione metabolism_Homo sapiens_hsa004801.21284379
43Arginine and proline metabolism_Homo sapiens_hsa003301.20418903
44Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.11038013
45Hedgehog signaling pathway_Homo sapiens_hsa043401.10487741
46Collecting duct acid secretion_Homo sapiens_hsa049661.08561208
47Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.04305575
48Renin secretion_Homo sapiens_hsa049241.03218819
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.02306505
50Glycosaminoglycan degradation_Homo sapiens_hsa005311.00447940
51Phototransduction_Homo sapiens_hsa047441.00084891
52Adipocytokine signaling pathway_Homo sapiens_hsa049200.97860969
53Insulin secretion_Homo sapiens_hsa049110.97534448
54Arginine biosynthesis_Homo sapiens_hsa002200.96131428
55Antigen processing and presentation_Homo sapiens_hsa046120.94365707
56Arachidonic acid metabolism_Homo sapiens_hsa005900.93871151
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.92544625
58Dorso-ventral axis formation_Homo sapiens_hsa043200.91351218
59Chemical carcinogenesis_Homo sapiens_hsa052040.89628124
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88404267
61Bile secretion_Homo sapiens_hsa049760.87147417
62Influenza A_Homo sapiens_hsa051640.85307743
63Thyroid hormone synthesis_Homo sapiens_hsa049180.85160895
64Purine metabolism_Homo sapiens_hsa002300.85055689
65Long-term potentiation_Homo sapiens_hsa047200.82905772
66Morphine addiction_Homo sapiens_hsa050320.80800264
67Estrogen signaling pathway_Homo sapiens_hsa049150.78380318
68Biosynthesis of amino acids_Homo sapiens_hsa012300.77107944
69Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.76600106
70cGMP-PKG signaling pathway_Homo sapiens_hsa040220.76560009
71Systemic lupus erythematosus_Homo sapiens_hsa053220.75243068
72Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.70375609
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.68506477
74Tyrosine metabolism_Homo sapiens_hsa003500.68377719
75Pancreatic secretion_Homo sapiens_hsa049720.66208932
76Salivary secretion_Homo sapiens_hsa049700.64361199
77Nicotine addiction_Homo sapiens_hsa050330.64079931
78Vascular smooth muscle contraction_Homo sapiens_hsa042700.60062172
79mRNA surveillance pathway_Homo sapiens_hsa030150.59901461
80Huntingtons disease_Homo sapiens_hsa050160.59812408
81Central carbon metabolism in cancer_Homo sapiens_hsa052300.59620615
82Legionellosis_Homo sapiens_hsa051340.57758079
83Synaptic vesicle cycle_Homo sapiens_hsa047210.57239300
84Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54607927
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54108297
86Fanconi anemia pathway_Homo sapiens_hsa034600.53855572
87Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.53373751
88Renin-angiotensin system_Homo sapiens_hsa046140.52521405
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51857536
90Retinol metabolism_Homo sapiens_hsa008300.51720822
91Gastric acid secretion_Homo sapiens_hsa049710.50893561
92Alcoholism_Homo sapiens_hsa050340.48542097
93Protein digestion and absorption_Homo sapiens_hsa049740.47660682
94Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.47424821
95MAPK signaling pathway_Homo sapiens_hsa040100.47275236
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.46191610
97Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.45789867
98Acute myeloid leukemia_Homo sapiens_hsa052210.45594911
99AMPK signaling pathway_Homo sapiens_hsa041520.44589011
100Sulfur metabolism_Homo sapiens_hsa009200.44568799
101Endocytosis_Homo sapiens_hsa041440.43175557
102Calcium signaling pathway_Homo sapiens_hsa040200.42718375
103ABC transporters_Homo sapiens_hsa020100.42560381
104Tight junction_Homo sapiens_hsa045300.41329347
105VEGF signaling pathway_Homo sapiens_hsa043700.39533485
106Serotonergic synapse_Homo sapiens_hsa047260.39042764
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37043542
108Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33791938
109Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.33271342
110Metabolic pathways_Homo sapiens_hsa011000.33179780
111cAMP signaling pathway_Homo sapiens_hsa040240.32593696
112Cocaine addiction_Homo sapiens_hsa050300.32357127
113Nitrogen metabolism_Homo sapiens_hsa009100.30877108
114Cholinergic synapse_Homo sapiens_hsa047250.30623260
115RNA transport_Homo sapiens_hsa030130.29742193
116Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27374573
117Jak-STAT signaling pathway_Homo sapiens_hsa046300.26784988
118Viral carcinogenesis_Homo sapiens_hsa052030.25965565
119Circadian entrainment_Homo sapiens_hsa047130.25904840
120Phosphatidylinositol signaling system_Homo sapiens_hsa040700.24765539
121Oxytocin signaling pathway_Homo sapiens_hsa049210.23636195
122GABAergic synapse_Homo sapiens_hsa047270.23524309
123ECM-receptor interaction_Homo sapiens_hsa045120.21884694
124Inositol phosphate metabolism_Homo sapiens_hsa005620.21618493
125Herpes simplex infection_Homo sapiens_hsa051680.21091438
126Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.20783996
127Transcriptional misregulation in cancer_Homo sapiens_hsa052020.20586309
128Pyrimidine metabolism_Homo sapiens_hsa002400.20502161
129Prolactin signaling pathway_Homo sapiens_hsa049170.18738715
130Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.18467680
131Salmonella infection_Homo sapiens_hsa051320.17918838
132B cell receptor signaling pathway_Homo sapiens_hsa046620.15881117
133Adherens junction_Homo sapiens_hsa045200.15865202
134HIF-1 signaling pathway_Homo sapiens_hsa040660.15342610
135Taste transduction_Homo sapiens_hsa047420.13997683
136Type II diabetes mellitus_Homo sapiens_hsa049300.09510152
137Insulin resistance_Homo sapiens_hsa049310.09348239
138Glutamatergic synapse_Homo sapiens_hsa047240.09118310
139Wnt signaling pathway_Homo sapiens_hsa043100.08306697
140Basal cell carcinoma_Homo sapiens_hsa052170.07969291
141Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.04548101

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