PRM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis, and are the major DNA-binding proteins in the nucleus of sperm in many vertebrates. They package the sperm DNA into a highly condensed complex in a volume less than 5% of a somatic cell nucleus. Many mammalian species have only one protamine (protamine 1); however, a few species, including human and mouse, have two. This gene encodes protamine 2, which is cleaved to give rise to a family of protamine 2 peptides. Alternatively spliced transcript variants have also been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1multicellular organism reproduction (GO:0032504)9.77936398
2epithelial cilium movement (GO:0003351)9.12405165
3plasma membrane fusion (GO:0045026)9.10580369
4motile cilium assembly (GO:0044458)9.08066894
5reproduction (GO:0000003)8.87819785
6axonemal dynein complex assembly (GO:0070286)8.73715374
7regulation of cilium movement (GO:0003352)8.62576450
8negative regulation of inclusion body assembly (GO:0090084)8.58009691
9protein targeting to Golgi (GO:0000042)7.71020246
10organic cation transport (GO:0015695)7.61714433
11rRNA methylation (GO:0031167)7.55327250
12response to pheromone (GO:0019236)7.50654887
13establishment of protein localization to Golgi (GO:0072600)7.38559005
14* spermatogenesis (GO:0007283)7.24220235
15* male gamete generation (GO:0048232)7.21512703
16retrograde transport, vesicle recycling within Golgi (GO:0000301)7.20872190
17sperm capacitation (GO:0048240)7.19450643
18cilium movement (GO:0003341)7.19057654
19phosphatidylethanolamine biosynthetic process (GO:0006646)7.03823375
20regulation of inclusion body assembly (GO:0090083)6.99681938
21single fertilization (GO:0007338)6.89854427
22microtubule depolymerization (GO:0007019)6.89580966
23synaptonemal complex organization (GO:0070193)6.82868239
24synaptonemal complex assembly (GO:0007130)6.81351651
25* gamete generation (GO:0007276)6.62251367
26phosphatidylethanolamine metabolic process (GO:0046337)6.49946420
27cilium or flagellum-dependent cell motility (GO:0001539)6.44961592
28epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.42567233
29rRNA modification (GO:0000154)6.36897172
30male meiosis (GO:0007140)6.15908376
31calcium ion-dependent exocytosis (GO:0017156)6.10226121
32centriole replication (GO:0007099)6.03504759
33fertilization (GO:0009566)5.98246075
34glycerol ether metabolic process (GO:0006662)5.86302905
35* chromosome condensation (GO:0030261)5.84675374
36spermatid nucleus differentiation (GO:0007289)5.83849047
37sexual reproduction (GO:0019953)5.72411640
38* DNA packaging (GO:0006323)5.67090422
39piRNA metabolic process (GO:0034587)5.66720261
40germ cell development (GO:0007281)5.60186433
41protein localization to Golgi apparatus (GO:0034067)5.52039115
42ether metabolic process (GO:0018904)5.41774324
43centriole assembly (GO:0098534)5.39793653
44cellular process involved in reproduction in multicellular organism (GO:0022412)5.39635988
45* multicellular organismal reproductive process (GO:0048609)5.20143770
46regulation of microtubule-based movement (GO:0060632)5.12268015
47cell recognition (GO:0008037)5.08848785
48single strand break repair (GO:0000012)5.06343106
49regulation of centriole replication (GO:0046599)5.01445373
50cellular ketone body metabolic process (GO:0046950)5.00918624
51regulation of Rab GTPase activity (GO:0032313)4.82044484
52positive regulation of Rab GTPase activity (GO:0032851)4.82044484
53microtubule severing (GO:0051013)4.79277845
54ventricular system development (GO:0021591)4.72642464
55seminiferous tubule development (GO:0072520)4.66346066
56chaperone-mediated protein complex assembly (GO:0051131)4.62390134
57chromosome organization involved in meiosis (GO:0070192)4.47098497
58regulation of transcription involved in cell fate commitment (GO:0060850)4.42606347
59ketone body metabolic process (GO:1902224)4.41588592
60sequestering of actin monomers (GO:0042989)4.34372979
61male meiosis I (GO:0007141)4.32200942
62* multicellular organismal development (GO:0007275)4.18744250
63multicellular organismal movement (GO:0050879)4.12883319
64musculoskeletal movement (GO:0050881)4.12883319
65left/right pattern formation (GO:0060972)4.12026618
66microtubule nucleation (GO:0007020)3.81714024
67glomerular visceral epithelial cell development (GO:0072015)3.77923566
68meiotic nuclear division (GO:0007126)3.75129191
69polyamine biosynthetic process (GO:0006596)3.73998257
70DNA methylation involved in gamete generation (GO:0043046)3.69762083
71glomerular epithelial cell development (GO:0072310)3.61934308
72regulation of somitogenesis (GO:0014807)3.60832198
73regulation of spindle checkpoint (GO:0090231)3.54709385
74negative regulation of Rho protein signal transduction (GO:0035024)3.53139129
75positive regulation of macrophage activation (GO:0043032)3.53000940
76microtubule polymerization or depolymerization (GO:0031109)3.52402967
77protein refolding (GO:0042026)3.51836209
78chromatin silencing (GO:0006342)3.48487202
79antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.45629639
80glycolytic process (GO:0006096)3.44077648
81response to acidic pH (GO:0010447)3.43734519
82meiosis I (GO:0007127)3.42034517
83protein K11-linked deubiquitination (GO:0035871)3.41589651
84protein polyglutamylation (GO:0018095)3.41569895
85nucleus organization (GO:0006997)3.35947591
86RNA destabilization (GO:0050779)3.34991209
87genitalia morphogenesis (GO:0035112)3.32051274
88cellular response to pH (GO:0071467)3.31206917
89homeostasis of number of cells within a tissue (GO:0048873)3.29932148
90regulation of interleukin-13 production (GO:0032656)3.29841608
91interferon-gamma secretion (GO:0072643)3.27799613
92nuclear pore complex assembly (GO:0051292)3.27714701
93mitotic sister chromatid cohesion (GO:0007064)3.25610996
94coenzyme catabolic process (GO:0009109)3.24095279
95RNA localization (GO:0006403)3.22529479
96mitochondrion degradation (GO:0000422)3.19836149
97cerebral cortex neuron differentiation (GO:0021895)3.18689582
98histone H3-K9 demethylation (GO:0033169)3.12656156
99regulation of T-helper 2 cell differentiation (GO:0045628)3.11639376
100amino-acid betaine transport (GO:0015838)3.10350911
101carnitine transport (GO:0015879)3.10350911
102membrane protein intracellular domain proteolysis (GO:0031293)3.09544712
103cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.09543574
104peptidyl-threonine dephosphorylation (GO:0035970)3.08274322
105nucleoside diphosphate phosphorylation (GO:0006165)3.01872034
106mitochondrial fission (GO:0000266)3.00900174
107regulation of phosphoprotein phosphatase activity (GO:0043666)2.99552348
108mitotic G1 DNA damage checkpoint (GO:0031571)2.97254317
109positive regulation of glycolytic process (GO:0045821)2.97151887
110regulation of cilium assembly (GO:1902017)2.92406944
111meiotic cell cycle (GO:0051321)2.91743339
112intra-Golgi vesicle-mediated transport (GO:0006891)2.91591042
113carnitine transmembrane transport (GO:1902603)2.86112978
114cranial nerve morphogenesis (GO:0021602)2.81573214
115positive regulation of guanylate cyclase activity (GO:0031284)2.80420451
116receptor recycling (GO:0001881)2.80125222
117polyol catabolic process (GO:0046174)2.79432855
118vesicle transport along microtubule (GO:0047496)2.78303168
119alditol metabolic process (GO:0019400)2.76304731
120GTP biosynthetic process (GO:0006183)2.72582012
121negative regulation of gene expression, epigenetic (GO:0045814)2.65703034
122nucleosome disassembly (GO:0006337)2.65603922
123protein-DNA complex disassembly (GO:0032986)2.65603922
124protein localization to cilium (GO:0061512)2.55881690
125meiotic cell cycle process (GO:1903046)2.54679887
126cellular biogenic amine biosynthetic process (GO:0042401)2.43900619
127amine biosynthetic process (GO:0009309)2.43900619
128UTP biosynthetic process (GO:0006228)2.43836926
129synapsis (GO:0007129)2.43668509
130protein depolymerization (GO:0051261)2.41047944
131cilium organization (GO:0044782)2.40540087
132cellular component assembly involved in morphogenesis (GO:0010927)2.38326631
133protein localization to chromosome, centromeric region (GO:0071459)2.37978738
134microtubule-based movement (GO:0007018)2.36801391
135sperm motility (GO:0030317)15.1663397
136cell wall macromolecule metabolic process (GO:0044036)13.5212816
137cell wall macromolecule catabolic process (GO:0016998)13.5212816
138acrosome reaction (GO:0007340)13.4117074
139fusion of sperm to egg plasma membrane (GO:0007342)11.9559542
140sperm-egg recognition (GO:0035036)11.6415892
141acrosome assembly (GO:0001675)11.5568991
142binding of sperm to zona pellucida (GO:0007339)10.7435732
143cell-cell recognition (GO:0009988)10.4240702
144spermatid development (GO:0007286)10.2567669

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.14501876
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.60906454
3EZH2_22144423_ChIP-Seq_EOC_Human4.60835651
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.46856231
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.38163454
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.21645858
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.93244646
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.83585368
9VDR_22108803_ChIP-Seq_LS180_Human2.82675891
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.60044969
11GATA1_26923725_Chip-Seq_HPCs_Mouse2.57294541
12CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.22673034
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.15776304
14VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.15729044
15ZNF274_21170338_ChIP-Seq_K562_Hela2.08671307
16CTBP1_25329375_ChIP-Seq_LNCAP_Human2.07606448
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.06961754
18EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.04275426
19FUS_26573619_Chip-Seq_HEK293_Human1.96765878
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.95824519
21DROSHA_22980978_ChIP-Seq_HELA_Human1.93646869
22FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.91180211
23RAC3_21632823_ChIP-Seq_H3396_Human1.86987931
24SOX2_22085726_ChIP-Seq_NPCs_Mouse1.84291187
25ERA_21632823_ChIP-Seq_H3396_Human1.82258089
26ELK4_26923725_Chip-Seq_MESODERM_Mouse1.80510844
27MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.80162428
28KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.76626283
29STAT1_17558387_ChIP-Seq_HELA_Human1.68029538
30FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.63990923
31* GATA3_21867929_ChIP-Seq_CD8_Mouse1.61608704
32TAF2_19829295_ChIP-Seq_ESCs_Human1.61562508
33TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.60382271
34* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.58959201
35UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.58697526
36PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.57564114
37ARNT_22903824_ChIP-Seq_MCF-7_Human1.53546254
38FLI1_27457419_Chip-Seq_LIVER_Mouse1.53254484
39MYC_19829295_ChIP-Seq_ESCs_Human1.53080703
40TDRD3_21172665_ChIP-Seq_MCF-7_Human1.52968206
41SMAD4_21741376_ChIP-Seq_EPCs_Human1.48774103
42ER_23166858_ChIP-Seq_MCF-7_Human1.48204970
43GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.47839727
44PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.46212635
45P68_20966046_ChIP-Seq_HELA_Human1.45903290
46P53_21459846_ChIP-Seq_SAOS-2_Human1.45575314
47E2F1_20622854_ChIP-Seq_HELA_Human1.44069454
48RBPJ_21746931_ChIP-Seq_IB4_Human1.42899259
49CBX2_22325352_ChIP-Seq_293T-Rex_Human1.42400687
50AUTS2_25519132_ChIP-Seq_293T-REX_Human1.42091473
51HNFA_21074721_ChIP-Seq_CACO-2_Human1.41794460
52REST_21632747_ChIP-Seq_MESCs_Mouse1.41609966
53OCT4_20526341_ChIP-Seq_ESCs_Human1.41569365
54CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.39318871
55LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.38993968
56WDR5_24793694_ChIP-Seq_LNCAP_Human1.38737920
57AR_25329375_ChIP-Seq_VCAP_Human1.38451202
58* TP63_22573176_ChIP-Seq_HFKS_Human1.38321293
59SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.38143233
60KDM2B_26808549_Chip-Seq_REH_Human1.36510628
61LXR_22292898_ChIP-Seq_THP-1_Human1.36468280
62SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.36369960
63TET1_21451524_ChIP-Seq_MESCs_Mouse1.35038763
64CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34811615
65SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34518079
66RAD21_21589869_ChIP-Seq_MESCs_Mouse1.34505025
67TP53_18474530_ChIP-ChIP_U2OS_Human1.34425809
68ETV1_20927104_ChIP-Seq_GIST48_Human1.33687516
69CBP_20019798_ChIP-Seq_JUKART_Human1.33451479
70IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33451479
71PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32945987
72ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.31021172
73GF1_26923725_Chip-Seq_HPCs_Mouse1.30570618
74TAL1_26923725_Chip-Seq_HPCs_Mouse1.29729349
75TP63_19390658_ChIP-ChIP_HaCaT_Human1.29276051
76RXRA_24833708_ChIP-Seq_LIVER_Mouse1.28573173
77SMAD3_21741376_ChIP-Seq_ESCs_Human1.28003616
78CEBPB_22108803_ChIP-Seq_LS180_Human1.27958709
79SMAD3_21741376_ChIP-Seq_EPCs_Human1.27422409
80CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.26782189
81JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.26563134
82MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.26043099
83GATA3_21867929_ChIP-Seq_TH1_Mouse1.25459336
84MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.25228168
85SPI1_26923725_Chip-Seq_HPCs_Mouse1.24933489
86MYC_27129775_Chip-Seq_CORNEA_Mouse1.24919885
87P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.24062599
88TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22583541
89SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.22396123
90GATA1_19941827_ChIP-Seq_MEL86_Mouse1.22249518
91TBL1_22424771_ChIP-Seq_293T_Human1.20249293
92PCGF2_27294783_Chip-Seq_ESCs_Mouse1.19826887
93P300_19829295_ChIP-Seq_ESCs_Human1.19032471
94RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.18663765
95CTCF_20526341_ChIP-Seq_ESCs_Human1.18173173
96* P300_27268052_Chip-Seq_Bcells_Human1.17654304
97TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17494364
98NFIB_24661679_ChIP-Seq_LUNG_Mouse1.17441691
99ERG_20517297_ChIP-Seq_VCAP_Human1.16128528
100CTBP2_25329375_ChIP-Seq_LNCAP_Human1.15713540
101RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.14811200
102PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.14700494
103PHF8_20622853_ChIP-Seq_HELA_Human1.14463566
104POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14244817
105TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14244817
106FLI1_21867929_ChIP-Seq_TH2_Mouse1.14224690
107YY1_22570637_ChIP-Seq_MALME-3M_Human1.14153895
108GATA6_21074721_ChIP-Seq_CACO-2_Human1.13647631
109GATA3_21878914_ChIP-Seq_MCF-7_Human1.12511976
110RARA_24833708_ChIP-Seq_LIVER_Mouse1.11901007
111TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10932310
112SA1_27219007_Chip-Seq_Bcells_Human1.10857815
113ESET_19884257_ChIP-Seq_ESCs_Mouse1.09921907
114SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.09210134
115SMC3_22415368_ChIP-Seq_MEFs_Mouse1.09076618
116SMRT_27268052_Chip-Seq_Bcells_Human1.08947468
117RUNX_20019798_ChIP-Seq_JUKART_Human1.08819398
118PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08577673
119KAP1_22055183_ChIP-Seq_ESCs_Mouse1.08346942
120SOX11_22085726_ChIP-Seq_ESNs_Mouse1.07327254
121SMAD4_21741376_ChIP-Seq_HESCs_Human1.06836697
122EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.05475277
123* BCOR_27268052_Chip-Seq_Bcells_Human1.05060871
124PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.05043416
125GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.04885135
126ELF1_20517297_ChIP-Seq_JURKAT_Human1.03977996
127NFYA_21822215_ChIP-Seq_K562_Human1.03927783
128SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03736641
129* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03697455
130EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.03585155
131BCL6_27268052_Chip-Seq_Bcells_Human1.03504908
132ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.02872931
133RUNX1_26923725_Chip-Seq_HPCs_Mouse1.02755455
134TAF15_26573619_Chip-Seq_HEK293_Human1.02440273
135EZH2_27294783_Chip-Seq_ESCs_Mouse1.02398396
136PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.01856899
137SMAD4_21799915_ChIP-Seq_A2780_Human1.01112297
138KLF5_25053715_ChIP-Seq_YYC3_Human1.00502418
139TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00453659
140CTCF_27219007_Chip-Seq_Bcells_Human0.99866014
141RUNX2_22187159_ChIP-Seq_PCA_Human0.99800467
142TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99573168
143KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99524945
144CBX2_27304074_Chip-Seq_ESCs_Mouse0.99306993
145LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98715178
146SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98365841
147ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.97948766
148STAT3_23295773_ChIP-Seq_U87_Human0.97694425
149KLF4_19829295_ChIP-Seq_ESCs_Human0.97234054
150NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.96916642
151ETV2_25802403_ChIP-Seq_MESCs_Mouse0.95431442
152FLI1_21867929_ChIP-Seq_CD8_Mouse0.94678734
153SUZ12_27294783_Chip-Seq_ESCs_Mouse0.93296430
154NFE2_27457419_Chip-Seq_LIVER_Mouse0.92847255
155* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.92734869
156NANOG_20526341_ChIP-Seq_ESCs_Human0.92517933
157CSB_26484114_Chip-Seq_FIBROBLAST_Human0.92319090
158PHF8_20622854_ChIP-Seq_HELA_Human0.90795428
159NFYB_21822215_ChIP-Seq_K562_Human0.89377472
160RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88422706
161KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.88284994
162SMC4_20622854_ChIP-Seq_HELA_Human0.88175139

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003698_abnormal_male_reproductive6.05377724
2* MP0001929_abnormal_gametogenesis5.50436323
3MP0005670_abnormal_white_adipose3.51816949
4MP0008877_abnormal_DNA_methylation3.43889417
5* MP0002161_abnormal_fertility/fecundity3.30906078
6MP0002210_abnormal_sex_determination3.16097621
7MP0001145_abnormal_male_reproductive2.69021519
8MP0000678_abnormal_parathyroid_gland2.35797288
9MP0000653_abnormal_sex_gland2.30574696
10MP0003718_maternal_effect2.28611366
11* MP0005410_abnormal_fertilization16.8679097
12MP0001485_abnormal_pinna_reflex1.80424195
13MP0005423_abnormal_somatic_nervous1.76558691
14MP0002132_abnormal_respiratory_system1.76391552
15MP0005451_abnormal_body_composition1.74150684
16MP0005310_abnormal_salivary_gland1.73627387
17MP0004233_abnormal_muscle_weight1.68647160
18MP0003646_muscle_fatigue1.62245725
19MP0002653_abnormal_ependyma_morphology1.60144359
20MP0005379_endocrine/exocrine_gland_phen1.58490241
21MP0001486_abnormal_startle_reflex1.50357841
22MP0002249_abnormal_larynx_morphology1.46202978
23MP0002234_abnormal_pharynx_morphology1.32582270
24MP0009053_abnormal_anal_canal1.30572968
25MP0004859_abnormal_synaptic_plasticity1.29439401
26MP0002160_abnormal_reproductive_system1.20533814
27MP0001963_abnormal_hearing_physiology1.15107807
28MP0002138_abnormal_hepatobiliary_system1.13868080
29MP0001765_abnormal_ion_homeostasis1.13450895
30MP0001984_abnormal_olfaction1.10780373
31MP0004510_myositis1.05492721
32MP0002127_abnormal_cardiovascular_syste1.04739385
33MP0005395_other_phenotype1.03925098
34MP0002735_abnormal_chemical_nociception1.03494373
35MP0005623_abnormal_meninges_morphology1.02742965
36MP0000026_abnormal_inner_ear0.96743312
37MP0005248_abnormal_Harderian_gland0.95722372
38MP0000955_abnormal_spinal_cord0.91739748
39MP0002282_abnormal_trachea_morphology0.90537259
40MP0003329_amyloid_beta_deposits0.79188834
41MP0002067_abnormal_sensory_capabilities0.76405829
42MP0002736_abnormal_nociception_after0.76055629
43MP0000681_abnormal_thyroid_gland0.75552638
44MP0005083_abnormal_biliary_tract0.74779438
45MP0003115_abnormal_respiratory_system0.73716821
46MP0002557_abnormal_social/conspecific_i0.70882496
47MP0005666_abnormal_adipose_tissue0.68178476
48MP0005636_abnormal_mineral_homeostasis0.68151152
49MP0005647_abnormal_sex_gland0.66274763
50MP0009697_abnormal_copulation0.65975546
51MP0003011_delayed_dark_adaptation0.65349938
52MP0000049_abnormal_middle_ear0.64616806
53MP0004085_abnormal_heartbeat0.64591653
54MP0001905_abnormal_dopamine_level0.64339082
55MP0001879_abnormal_lymphatic_vessel0.63365310
56MP0004036_abnormal_muscle_relaxation0.62718864
57MP0003077_abnormal_cell_cycle0.61525558
58MP0001666_abnormal_nutrient_absorption0.61357943
59MP0005167_abnormal_blood-brain_barrier0.59164994
60MP0009046_muscle_twitch0.57666270
61MP0002269_muscular_atrophy0.57403572
62MP0000003_abnormal_adipose_tissue0.55648384
63MP0008995_early_reproductive_senescence0.55328663
64MP0001764_abnormal_homeostasis0.55067163
65MP0005367_renal/urinary_system_phenotyp0.55016533
66MP0000516_abnormal_urinary_system0.55016533
67MP0004484_altered_response_of0.54305080
68MP0000534_abnormal_ureter_morphology0.53790331
69MP0005389_reproductive_system_phenotype0.53667431
70MP0002733_abnormal_thermal_nociception0.52525863
71MP0002572_abnormal_emotion/affect_behav0.51704746
72MP0002139_abnormal_hepatobiliary_system0.50864533
73MP0008058_abnormal_DNA_repair0.50294836
74MP0006036_abnormal_mitochondrial_physio0.49869121
75MP0003137_abnormal_impulse_conducting0.49689714
76MP0001440_abnormal_grooming_behavior0.47502025
77MP0001968_abnormal_touch/_nociception0.47394210
78MP0001324_abnormal_eye_pigmentation0.46735408
79MP0005377_hearing/vestibular/ear_phenot0.46699610
80MP0003878_abnormal_ear_physiology0.46699610
81MP0000613_abnormal_salivary_gland0.46695761
82MP0000249_abnormal_blood_vessel0.45737836
83MP0000604_amyloidosis0.44779522
84MP0008961_abnormal_basal_metabolism0.44640843
85MP0005535_abnormal_body_temperature0.41811675
86MP0001270_distended_abdomen0.41770794
87MP0002734_abnormal_mechanical_nocicepti0.41496049
88MP0005408_hypopigmentation0.41370623
89MP0009745_abnormal_behavioral_response0.41349611
90MP0003699_abnormal_female_reproductive0.40879473
91MP0005397_hematopoietic_system_phenotyp0.40263122
92MP0001545_abnormal_hematopoietic_system0.40263122
93MP0000230_abnormal_systemic_arterial0.40246780
94MP0001293_anophthalmia0.39160856
95MP0004133_heterotaxia0.38337486
96MP0000358_abnormal_cell_content/0.38240591
97MP0009278_abnormal_bone_marrow0.37055531
98MP0005084_abnormal_gallbladder_morpholo0.36801414
99MP0001501_abnormal_sleep_pattern0.36249970
100MP0009115_abnormal_fat_cell0.35949452
101MP0004811_abnormal_neuron_physiology0.35874030
102MP0003942_abnormal_urinary_system0.35807040
103MP0001970_abnormal_pain_threshold0.34657269
104MP0005253_abnormal_eye_physiology0.34265001
105MP0000470_abnormal_stomach_morphology0.32858366
106MP0000569_abnormal_digit_pigmentation0.31814689
107MP0003633_abnormal_nervous_system0.31631064
108MP0003091_abnormal_cell_migration0.31253223
109MP0004270_analgesia0.31018843
110MP0004084_abnormal_cardiac_muscle0.30940586
111MP0005551_abnormal_eye_electrophysiolog0.30104005
112MP0003806_abnormal_nucleotide_metabolis0.29324005
113MP0002169_no_abnormal_phenotype0.29077839
114MP0002873_normal_phenotype0.28899017
115MP0002928_abnormal_bile_duct0.28830595
116MP0002909_abnormal_adrenal_gland0.28101658
117MP0003879_abnormal_hair_cell0.27500524
118MP0001849_ear_inflammation0.27164876
119MP0008875_abnormal_xenobiotic_pharmacok0.26687332
120MP0003631_nervous_system_phenotype0.26520361
121MP0001730_embryonic_growth_arrest0.26124274
122MP0003948_abnormal_gas_homeostasis0.25635152
123MP0004145_abnormal_muscle_electrophysio0.25532458
124MP0005391_vision/eye_phenotype0.25002048
125MP0002971_abnormal_brown_adipose0.24015085
126MP0005365_abnormal_bile_salt0.24000854
127MP0002295_abnormal_pulmonary_circulatio0.23613953
128MP0003861_abnormal_nervous_system0.23388810
129MP0002152_abnormal_brain_morphology0.23092092
130MP0005375_adipose_tissue_phenotype0.23000811
131MP0002822_catalepsy0.22143410
132MP0004742_abnormal_vestibular_system0.21689263
133MP0008569_lethality_at_weaning0.21604190
134MP0004043_abnormal_pH_regulation0.21440123
135MP0000462_abnormal_digestive_system0.21113761
136MP0006035_abnormal_mitochondrial_morpho0.21028721
137MP0000751_myopathy0.19457872
138MP0005360_urolithiasis0.18947671
139MP0001348_abnormal_lacrimal_gland0.18312085
140MP0003787_abnormal_imprinting0.18108544
141MP0002118_abnormal_lipid_homeostasis0.17625137
142MP0002272_abnormal_nervous_system0.16902387
143MP0005319_abnormal_enzyme/_coenzyme0.16877241
144MP0000920_abnormal_myelination0.16618498
145MP0000001_mammalian_phenotype0.16440019
146MP0002693_abnormal_pancreas_physiology0.16325113
147MP0010329_abnormal_lipoprotein_level0.15941462
148MP0003635_abnormal_synaptic_transmissio0.15671923
149MP0003950_abnormal_plasma_membrane0.15465245
150MP0004019_abnormal_vitamin_homeostasis0.15260974
151MP0008770_decreased_survivor_rate0.14904207
152MP0003959_abnormal_lean_body0.14752109
153MP0002229_neurodegeneration0.14681919
154MP0003279_aneurysm0.14476012
155MP0002063_abnormal_learning/memory/cond0.13815844
156MP0002106_abnormal_muscle_physiology0.13790301

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.27165538
2Abnormal respiratory motile cilium morphology (HP:0005938)9.23101935
3Abnormal respiratory epithelium morphology (HP:0012253)9.23101935
4Severe visual impairment (HP:0001141)7.66866715
5Infertility (HP:0000789)7.54412013
6Chronic bronchitis (HP:0004469)7.36560974
7Rhinitis (HP:0012384)7.15443424
8Abnormal ciliary motility (HP:0012262)7.10605275
9Nasal polyposis (HP:0100582)6.48271405
10Chronic hepatic failure (HP:0100626)5.78424244
11Male infertility (HP:0003251)5.46939595
12Abnormality of the nasal mucosa (HP:0000433)5.34602975
13Hyperkalemia (HP:0002153)4.91883821
14Resting tremor (HP:0002322)4.76048915
15Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.64756858
16Bony spicule pigmentary retinopathy (HP:0007737)4.58220391
17Attenuation of retinal blood vessels (HP:0007843)4.54454053
18Bronchitis (HP:0012387)4.51151213
19Cone-rod dystrophy (HP:0000548)4.42011402
20Abnormality of macular pigmentation (HP:0008002)4.27585931
21Bronchiectasis (HP:0002110)4.23207007
22Abnormal spermatogenesis (HP:0008669)3.93534395
23Hypoalphalipoproteinemia (HP:0003233)3.86473426
24Facial shape deformation (HP:0011334)3.75398937
25Potter facies (HP:0002009)3.75398937
26Aplasia/Hypoplasia of the earlobes (HP:0009906)3.72868824
27Nephronophthisis (HP:0000090)3.71322970
28Progressive sensorineural hearing impairment (HP:0000408)3.70550208
29Hypoplasia of the thymus (HP:0000778)3.69485092
30Menstrual irregularities (HP:0000858)3.57663595
31Abnormal rod and cone electroretinograms (HP:0008323)3.35869345
32Amelogenesis imperfecta (HP:0000705)3.28956315
33Renovascular hypertension (HP:0100817)3.25009370
34Recurrent otitis media (HP:0000403)3.20213706
35Postural instability (HP:0002172)3.19523761
36Recurrent sinusitis (HP:0011108)3.04044855
37Insulin-resistant diabetes mellitus (HP:0000831)3.01581630
38Hypoplastic ischia (HP:0003175)2.99614599
39Abnormal gallbladder physiology (HP:0012438)2.98230215
40Cholecystitis (HP:0001082)2.98230215
41Enlarged epiphyses (HP:0010580)2.95672527
42Progressive cerebellar ataxia (HP:0002073)2.88805741
43Portal hypertension (HP:0001409)2.86679824
44Abnormality of dental color (HP:0011073)2.86671165
45Unilateral renal agenesis (HP:0000122)2.75613812
46Abnormality of the renal medulla (HP:0100957)2.73377855
47Abnormality of the ischium (HP:0003174)2.70693948
48Abnormality of the aortic arch (HP:0012303)2.70014157
49Impulsivity (HP:0100710)2.67442467
50Abnormality of potassium homeostasis (HP:0011042)2.67145393
51Abnormality of the hepatic vasculature (HP:0006707)2.62922807
52Recurrent bronchitis (HP:0002837)2.60878039
53Generalized aminoaciduria (HP:0002909)2.60537142
54Abnormality of the costochondral junction (HP:0000919)2.54635763
55Congenital malformation of the right heart (HP:0011723)2.50550296
56Double outlet right ventricle (HP:0001719)2.50550296
57Tubular atrophy (HP:0000092)2.48756901
58Increased purine levels (HP:0004368)2.44388015
59Hyperuricemia (HP:0002149)2.44388015
60Tubulointerstitial nephritis (HP:0001970)2.43955336
61Dyschromatopsia (HP:0007641)2.41441226
62Ventricular tachycardia (HP:0004756)2.38138022
63Progressive hearing impairment (HP:0001730)2.37876908
64Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.33587404
65Molar tooth sign on MRI (HP:0002419)2.33066005
66Abnormality of midbrain morphology (HP:0002418)2.33066005
67Choroideremia (HP:0001139)2.32943074
68Subcapsular cataract (HP:0000523)2.29025042
69Tubulointerstitial abnormality (HP:0001969)2.28897481
70Azoospermia (HP:0000027)2.27761040
71Myokymia (HP:0002411)2.22166969
72Abnormality of the parathyroid morphology (HP:0011766)2.18753986
73Decreased central vision (HP:0007663)2.16233210
74Osteomalacia (HP:0002749)2.15040968
75Neurofibrillary tangles (HP:0002185)2.14512045
76Hemorrhage of the eye (HP:0011885)2.09078884
77Focal segmental glomerulosclerosis (HP:0000097)2.08062546
78Flattened epiphyses (HP:0003071)2.05631101
79Medial flaring of the eyebrow (HP:0010747)2.04210605
80Recurrent pneumonia (HP:0006532)2.03890385
81Tubulointerstitial fibrosis (HP:0005576)2.01887387
82Intellectual disability, moderate (HP:0002342)2.01112612
83Dynein arm defect of respiratory motile cilia (HP:0012255)13.4501612
84Absent/shortened dynein arms (HP:0200106)13.4501612
85Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.5642919
86Spastic tetraparesis (HP:0001285)1.99812239
87Gonadotropin excess (HP:0000837)1.99630080
88Hypophosphatemic rickets (HP:0004912)1.96921399
89Hyponatremia (HP:0002902)1.96125938
90Widely patent fontanelles and sutures (HP:0004492)1.93316176
91Exercise-induced myalgia (HP:0003738)1.93305544
92Decreased electroretinogram (ERG) amplitude (HP:0000654)1.93303648
93Hypolipoproteinemia (HP:0010981)1.91966984
94Bradycardia (HP:0001662)1.88767761
95Renal Fanconi syndrome (HP:0001994)1.87397792
96Insulin resistance (HP:0000855)1.83431255
97Tetany (HP:0001281)1.82889557
98Optic nerve hypoplasia (HP:0000609)1.80934354
99Abnormality of the epiphysis of the femoral head (HP:0010574)1.77013552
100Epiphyseal dysplasia (HP:0002656)1.76920655
101Myoglobinuria (HP:0002913)1.76586004
102Cerebral inclusion bodies (HP:0100314)1.75721897
103Abnormal drinking behavior (HP:0030082)1.75077566
104Polydipsia (HP:0001959)1.75077566
105Recurrent corneal erosions (HP:0000495)1.73887126
106Abnormality of chloride homeostasis (HP:0011422)1.71775230
107Obsessive-compulsive behavior (HP:0000722)1.70539614
108Upper limb muscle weakness (HP:0003484)1.68426752
109Abnormal biliary tract physiology (HP:0012439)1.68104725
110Bile duct proliferation (HP:0001408)1.68104725
111Gingivitis (HP:0000230)1.66349298
112Flat capital femoral epiphysis (HP:0003370)1.65898198
113Hypoparathyroidism (HP:0000829)1.65529591
114Sensory axonal neuropathy (HP:0003390)1.62497397
115Exercise-induced muscle cramps (HP:0003710)1.61564296
116Easy fatigability (HP:0003388)1.61318434
117Abnormality of renal excretion (HP:0011036)1.60737950
118Asymmetric septal hypertrophy (HP:0001670)1.59094745
119Hypercholesterolemia (HP:0003124)1.57726951
120Bundle branch block (HP:0011710)1.57689316
121Rhabdomyolysis (HP:0003201)1.57353232
122Heterotopia (HP:0002282)1.55086250
123Stage 5 chronic kidney disease (HP:0003774)1.54684945
124Abnormality of the neuromuscular junction (HP:0003398)1.53015701
125Fatigable weakness (HP:0003473)1.53015701
126Aplasia/Hypoplasia of the lens (HP:0008063)1.52879655
127Neoplasm of the heart (HP:0100544)1.51449802
128Abnormal urine output (HP:0012590)1.45957622
129Loss of speech (HP:0002371)1.45489218
130Postaxial foot polydactyly (HP:0001830)1.45364570
131Constricted visual fields (HP:0001133)1.44311556
132Hypoplasia of the capital femoral epiphysis (HP:0003090)1.43963309
133Congenital hepatic fibrosis (HP:0002612)1.43009000
134Bell-shaped thorax (HP:0001591)1.38486145
135Abnormality of the renal cortex (HP:0011035)1.36851360
136Decreased muscle mass (HP:0003199)1.33632326
137Oculomotor apraxia (HP:0000657)1.33140892
138Short ribs (HP:0000773)1.33119615
139Abnormal ventriculo-arterial connection (HP:0011563)1.33062177
140Transposition of the great arteries (HP:0001669)1.33062177
141Abnormal connection of the cardiac segments (HP:0011545)1.33062177
142Generalized muscle weakness (HP:0003324)1.30561121
143Type 2 muscle fiber atrophy (HP:0003554)1.26838617
144Bulbar palsy (HP:0001283)1.24061146
145Abnormality of dentin (HP:0010299)1.23605787
146Renal dysplasia (HP:0000110)1.23169543
147Cerebellar dysplasia (HP:0007033)1.22982803
148Hemiparesis (HP:0001269)1.22654633
149Deformed sella turcica (HP:0002681)1.22368840
150Postaxial hand polydactyly (HP:0001162)1.20135277
151Global brain atrophy (HP:0002283)1.19780005
152Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.19657599
153Retinal dysplasia (HP:0007973)1.18665760
154Aplasia/Hypoplasia affecting the retina (HP:0008061)1.18040706
155Truncal obesity (HP:0001956)1.17915587
156Polymicrogyria (HP:0002126)1.16900718
157Cystic liver disease (HP:0006706)1.16590244
158Facial cleft (HP:0002006)1.16159972
159Broad distal phalanx of finger (HP:0009836)1.15361348
160Short femoral neck (HP:0100864)1.15136956
161Cleft eyelid (HP:0000625)1.14422047
162Personality changes (HP:0000751)1.14402493
163Polyuria (HP:0000103)1.14168257
164Taurodontia (HP:0000679)1.12593667

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK48.95852783
2TESK17.53041118
3PDK47.31087642
4PDK37.31087642
5PRKD35.44928847
6ICK5.33382561
7PDK24.70658497
8DDR23.85100895
9BRD43.77473826
10INSRR3.70935124
11PLK23.31729061
12MAP4K22.72271312
13PTK2B2.18564615
14WNK42.14000215
15STK382.11212864
16STK392.08581939
17DYRK1B1.97131777
18PIK3CG1.96050990
19MST1R1.65666746
20CDK121.53926978
21PDK11.48184646
22NEK21.48064101
23PNCK1.33473478
24CDK71.13321905
25RIPK41.12232888
26PDPK11.11769475
27AKT31.10831695
28CAMK1D0.97959978
29DYRK30.97919860
30KSR20.95714998
31MAPK150.91471881
32TYRO30.87088591
33EEF2K0.85249056
34SIK20.85139860
35IRAK10.82650121
36MAP3K90.81426020
37MAP3K110.79211527
38WNK10.76271743
39CCNB10.69687936
40TESK20.69266333
41PINK10.68159031
42LATS20.67806585
43PASK0.64228716
44MAP2K20.63721354
45NTRK20.62018027
46RPS6KA20.60884138
47MAP3K20.59753050
48MUSK0.58918231
49CAMK10.57681093
50TTK0.56257838
51UHMK10.55686790
52MAP3K100.55528723
53SGK2230.53680355
54SGK4940.53680355
55MAP2K60.53482955
56CHEK20.53212580
57PRKCG0.51916886
58STK30.49085925
59ROCK10.48884618
60PRKAA20.48876212
61IRAK20.48013612
62TIE10.47677062
63CDK30.46865350
64MAP3K80.46128514
65LATS10.45706478
66PAK10.43369947
67MAPK10.41742627
68STK38L0.39380358
69MAPKAPK50.37703236
70BMPR1B0.37034923
71PAK40.35865162
72SGK10.32938626
73LMTK20.32861384
74CAMK1G0.32816263
75CAMK40.32702657
76CDK40.32254649
77PAK20.32002337
78MARK20.31822323
79CAMKK10.31805651
80PRKCZ0.30639604
81NTRK30.30052761
82RPS6KL10.28642267
83RPS6KC10.28642267
84CHEK10.28588453
85CDK150.28514625
86CDK180.25429347
87RPS6KA60.25253779
88PRKCQ0.24728950
89MAPK140.24153078
90ARAF0.23661181
91CDK11A0.23582470
92MAPK100.21307314
93MET0.20508049
94PRKG20.19116428
95MTOR0.19064663
96CDK140.18820299
97ATM0.18067874
98SGK20.16023182
99PRKAA10.15487077
100BRAF0.15263069
101AKT10.15009930
102JAK30.14937887
103BRSK10.14903055
104BRSK20.14213053
105MAPK110.13631982
106CSF1R0.13312663
107STK100.12812174
108RPS6KA10.12127817
109OXSR10.11786464
110TNIK0.11076741
111RPS6KB10.10965944
112CLK10.10716358
113PRKCD0.10593235
114FER0.09617906
115BLK0.09592529
116ATR0.09221722
117SGK30.07079992
118GSK3B0.06993555
119CSNK2A10.06972936
120MINK10.06664651
121CAMK2A0.06105803
122PIM10.06008797
123MAPK90.05994687
124STK110.05270465
125NEK60.04968409
126CDK60.04887069
127PRKCA0.04227536
128ACVR1B0.03793682
129PRKACG0.03613495
130PRKCB0.03503015
131MAPK80.03309652
132PAK60.02877387
133MARK30.02859686
134PLK10.02503410
135EPHB10.02481204
136PRKG10.02154790
137MAP3K10.02109220
138TRIB30.01991147
139PKN10.01010022
140AURKA0.00090730
141CSK-0.0596293
142TTN-0.0584796
143PRKACB-0.0501017
144SRC-0.0491200
145MAP3K4-0.0488315
146IGF1R-0.0478132
147CSNK1D-0.0384436
148PRKACA-0.0293674
149MARK1-0.0287472
150RPS6KA3-0.0232423
151PDGFRB-0.0220577
152EGFR-0.0199776
153CSNK2A2-0.0125571
154CDK2-0.0083540
155CDK1-0.0043680

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.05169455
2Fatty acid biosynthesis_Homo sapiens_hsa000615.32951607
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.51824687
4Olfactory transduction_Homo sapiens_hsa047403.46325066
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.43244205
6Linoleic acid metabolism_Homo sapiens_hsa005913.33176279
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.30536132
8Pyruvate metabolism_Homo sapiens_hsa006202.92960768
9Vitamin B6 metabolism_Homo sapiens_hsa007502.73066121
10Carbohydrate digestion and absorption_Homo sapiens_hsa049732.59149361
11Glucagon signaling pathway_Homo sapiens_hsa049222.41068842
12Butanoate metabolism_Homo sapiens_hsa006502.32563307
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.31180486
14Propanoate metabolism_Homo sapiens_hsa006402.17747881
15Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.16675091
16Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.09470832
17PPAR signaling pathway_Homo sapiens_hsa033201.91914996
18Fat digestion and absorption_Homo sapiens_hsa049751.82613392
19Glycerolipid metabolism_Homo sapiens_hsa005611.81748309
20Glycerophospholipid metabolism_Homo sapiens_hsa005641.81133421
21Fatty acid degradation_Homo sapiens_hsa000711.75264568
22Basal transcription factors_Homo sapiens_hsa030221.75238634
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.74234324
24Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.73015343
25Fatty acid metabolism_Homo sapiens_hsa012121.69879432
26Mineral absorption_Homo sapiens_hsa049781.68613995
27Selenocompound metabolism_Homo sapiens_hsa004501.68165459
28Fructose and mannose metabolism_Homo sapiens_hsa000511.66640975
29Ether lipid metabolism_Homo sapiens_hsa005651.59135525
30Phenylalanine metabolism_Homo sapiens_hsa003601.53837674
31Amphetamine addiction_Homo sapiens_hsa050311.51247833
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.41338498
33Cardiac muscle contraction_Homo sapiens_hsa042601.37069327
34Carbon metabolism_Homo sapiens_hsa012001.34407430
35Oocyte meiosis_Homo sapiens_hsa041141.25639909
36Type I diabetes mellitus_Homo sapiens_hsa049401.24056728
37Pentose phosphate pathway_Homo sapiens_hsa000301.19504392
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.16959101
39Hedgehog signaling pathway_Homo sapiens_hsa043401.10985262
40Glutathione metabolism_Homo sapiens_hsa004801.10638041
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.09578822
42Collecting duct acid secretion_Homo sapiens_hsa049661.09239734
43Allograft rejection_Homo sapiens_hsa053301.07326567
44Autoimmune thyroid disease_Homo sapiens_hsa053201.06194860
45Phototransduction_Homo sapiens_hsa047441.05304100
46Arginine and proline metabolism_Homo sapiens_hsa003301.02547595
47Insulin secretion_Homo sapiens_hsa049111.01641369
48Glycosaminoglycan degradation_Homo sapiens_hsa005310.98608826
49Renin secretion_Homo sapiens_hsa049240.98269513
50Cysteine and methionine metabolism_Homo sapiens_hsa002700.97567705
51Adipocytokine signaling pathway_Homo sapiens_hsa049200.96504420
52Chemical carcinogenesis_Homo sapiens_hsa052040.94741432
53Arginine biosynthesis_Homo sapiens_hsa002200.94430506
54Graft-versus-host disease_Homo sapiens_hsa053320.93859992
55Antigen processing and presentation_Homo sapiens_hsa046120.93804100
56Bile secretion_Homo sapiens_hsa049760.93775503
57Arachidonic acid metabolism_Homo sapiens_hsa005900.92399768
58Dorso-ventral axis formation_Homo sapiens_hsa043200.90068580
59Morphine addiction_Homo sapiens_hsa050320.89809972
60Thyroid hormone synthesis_Homo sapiens_hsa049180.86883612
61Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.86758152
62Purine metabolism_Homo sapiens_hsa002300.86164228
63Biosynthesis of amino acids_Homo sapiens_hsa012300.86115097
64Viral myocarditis_Homo sapiens_hsa054160.85085094
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79452726
66Long-term potentiation_Homo sapiens_hsa047200.78117991
67Estrogen signaling pathway_Homo sapiens_hsa049150.76177068
68cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75025147
69Influenza A_Homo sapiens_hsa051640.74516773
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.74332840
71Pancreatic secretion_Homo sapiens_hsa049720.70791471
72Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70028376
73Salivary secretion_Homo sapiens_hsa049700.69926849
74Nicotine addiction_Homo sapiens_hsa050330.66269919
75Tyrosine metabolism_Homo sapiens_hsa003500.65212029
76Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.60689284
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.59682065
78Synaptic vesicle cycle_Homo sapiens_hsa047210.59187683
79Central carbon metabolism in cancer_Homo sapiens_hsa052300.57775766
80Legionellosis_Homo sapiens_hsa051340.57531678
81Gastric acid secretion_Homo sapiens_hsa049710.55633093
82Huntingtons disease_Homo sapiens_hsa050160.55127192
83mRNA surveillance pathway_Homo sapiens_hsa030150.54510825
84Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.54233804
85Aldosterone synthesis and secretion_Homo sapiens_hsa049250.53627519
86Systemic lupus erythematosus_Homo sapiens_hsa053220.50997159
87Protein digestion and absorption_Homo sapiens_hsa049740.50361187
88Renin-angiotensin system_Homo sapiens_hsa046140.50173637
89Sulfur metabolism_Homo sapiens_hsa009200.50165012
90Tight junction_Homo sapiens_hsa045300.49265196
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48877932
92Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48256594
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47621848
94MAPK signaling pathway_Homo sapiens_hsa040100.47077975
95Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.46531110
96Serotonergic synapse_Homo sapiens_hsa047260.46086482
97Maturity onset diabetes of the young_Homo sapiens_hsa049500.45999159
98Acute myeloid leukemia_Homo sapiens_hsa052210.43504596
99ABC transporters_Homo sapiens_hsa020100.43211756
100Fanconi anemia pathway_Homo sapiens_hsa034600.42686683
101Calcium signaling pathway_Homo sapiens_hsa040200.41627748
102Retinol metabolism_Homo sapiens_hsa008300.41250072
103Endocytosis_Homo sapiens_hsa041440.41249372
104AMPK signaling pathway_Homo sapiens_hsa041520.38919631
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38130950
106Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36636995
107Nitrogen metabolism_Homo sapiens_hsa009100.35941392
108VEGF signaling pathway_Homo sapiens_hsa043700.35569555
109Cholinergic synapse_Homo sapiens_hsa047250.34840848
110Metabolic pathways_Homo sapiens_hsa011000.34107122
111Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33326771
112Alcoholism_Homo sapiens_hsa050340.32263089
113cAMP signaling pathway_Homo sapiens_hsa040240.31180673
114GABAergic synapse_Homo sapiens_hsa047270.30442776
115Cocaine addiction_Homo sapiens_hsa050300.29318007
116Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.26512162
117RNA transport_Homo sapiens_hsa030130.26049125
118Transcriptional misregulation in cancer_Homo sapiens_hsa052020.24422865
119Circadian entrainment_Homo sapiens_hsa047130.24267352
120Oxytocin signaling pathway_Homo sapiens_hsa049210.23933959
121Pyrimidine metabolism_Homo sapiens_hsa002400.23140481
122ECM-receptor interaction_Homo sapiens_hsa045120.21993182
123Jak-STAT signaling pathway_Homo sapiens_hsa046300.21715948
124Viral carcinogenesis_Homo sapiens_hsa052030.21355744
125Phosphatidylinositol signaling system_Homo sapiens_hsa040700.21129670
126Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.20283211
127Prolactin signaling pathway_Homo sapiens_hsa049170.20058445
128Adherens junction_Homo sapiens_hsa045200.18761821
129Inositol phosphate metabolism_Homo sapiens_hsa005620.18554303
130Salmonella infection_Homo sapiens_hsa051320.15406898
131Taste transduction_Homo sapiens_hsa047420.14352433
132HIF-1 signaling pathway_Homo sapiens_hsa040660.13360427
133B cell receptor signaling pathway_Homo sapiens_hsa046620.12318997
134Glutamatergic synapse_Homo sapiens_hsa047240.10199869
135Type II diabetes mellitus_Homo sapiens_hsa049300.07524419
136Wnt signaling pathway_Homo sapiens_hsa043100.07070851
137Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.06772423
138Basal cell carcinoma_Homo sapiens_hsa052170.06068368
139Insulin resistance_Homo sapiens_hsa049310.04199926

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