PRMT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the protein arginine N-methyltransferase (PRMT) family. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to terminal guanidino nitrogen atoms. The encoded protein is a type I PRMT and is responsible for the majority of cellular arginine methylation activity. Increased expression of this gene may play a role in many types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of integrated proviral latency (GO:0075713)5.20790230
2DNA unwinding involved in DNA replication (GO:0006268)4.90167552
3pre-miRNA processing (GO:0031054)4.50764604
4nuclear pore organization (GO:0006999)4.45414817
5protein localization to kinetochore (GO:0034501)4.40304570
6negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.35852373
7regulation of posttranscriptional gene silencing (GO:0060147)4.34519609
8regulation of gene silencing by miRNA (GO:0060964)4.34519609
9regulation of gene silencing by RNA (GO:0060966)4.34519609
10establishment of viral latency (GO:0019043)4.28750862
11nuclear pore complex assembly (GO:0051292)4.27327369
12paraxial mesoderm development (GO:0048339)4.07945665
13heterochromatin organization (GO:0070828)4.06223409
14folic acid-containing compound biosynthetic process (GO:0009396)4.01965551
15DNA replication-dependent nucleosome organization (GO:0034723)3.96041708
16DNA replication-dependent nucleosome assembly (GO:0006335)3.96041708
17negative regulation of RNA splicing (GO:0033119)3.91718546
18regulation of translational fidelity (GO:0006450)3.87329957
19proline biosynthetic process (GO:0006561)3.85872789
20mitotic nuclear envelope disassembly (GO:0007077)3.82908021
21negative regulation of mRNA processing (GO:0050686)3.80189158
22mitotic sister chromatid segregation (GO:0000070)3.69930579
23ribosomal small subunit assembly (GO:0000028)3.65931722
24IMP biosynthetic process (GO:0006188)3.64176925
25sister chromatid segregation (GO:0000819)3.62944158
26membrane disassembly (GO:0030397)3.61024063
27nuclear envelope disassembly (GO:0051081)3.61024063
28viral mRNA export from host cell nucleus (GO:0046784)3.59723340
29spliceosomal tri-snRNP complex assembly (GO:0000244)3.58639278
30L-serine metabolic process (GO:0006563)3.52471544
31protein localization to chromosome, centromeric region (GO:0071459)3.50442594
32DNA duplex unwinding (GO:0032508)3.49979893
33formation of translation preinitiation complex (GO:0001731)3.48585709
34protein complex localization (GO:0031503)3.47228662
35DNA geometric change (GO:0032392)3.46914570
36ribonucleoprotein complex biogenesis (GO:0022613)3.44958660
37regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.44495475
38regulation of mitochondrial translation (GO:0070129)3.40154011
39negative regulation of mRNA metabolic process (GO:1903312)3.38330174
40dosage compensation (GO:0007549)3.37928575
41mRNA stabilization (GO:0048255)3.35654228
42RNA stabilization (GO:0043489)3.35654228
43* histone arginine methylation (GO:0034969)3.31394380
44DNA replication initiation (GO:0006270)3.30201135
45DNA strand elongation involved in DNA replication (GO:0006271)3.29465975
46rRNA transcription (GO:0009303)3.29024982
47chromatin assembly (GO:0031497)3.28703703
48telomere maintenance via recombination (GO:0000722)3.28217569
49mitotic nuclear envelope reassembly (GO:0007084)3.28002959
50nuclear envelope reassembly (GO:0031468)3.28002959
51protein maturation by protein folding (GO:0022417)3.24368265
52nucleobase-containing small molecule interconversion (GO:0015949)3.18552718
53establishment of apical/basal cell polarity (GO:0035089)3.18033288
54viral transcription (GO:0019083)3.16938962
55maturation of SSU-rRNA (GO:0030490)3.11833561
56translational termination (GO:0006415)3.10812488
57base-excision repair (GO:0006284)3.10605886
58DNA strand elongation (GO:0022616)3.09950612
59mitotic recombination (GO:0006312)3.09229897
60pore complex assembly (GO:0046931)3.08793918
61regulation of translational termination (GO:0006449)3.08531964
62negative regulation of histone methylation (GO:0031061)3.07546531
63COPI coating of Golgi vesicle (GO:0048205)3.06768578
64Golgi transport vesicle coating (GO:0048200)3.06768578
65RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.04700485
66mRNA splicing, via spliceosome (GO:0000398)3.04700485
67IMP metabolic process (GO:0046040)3.04414632
68tRNA aminoacylation for protein translation (GO:0006418)3.03540620
69regulation of mammary gland epithelial cell proliferation (GO:0033599)3.03348314
70nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.02909460
71RNA splicing, via transesterification reactions (GO:0000375)3.01877315
72polarized epithelial cell differentiation (GO:0030859)3.00303989
73regulation of sister chromatid cohesion (GO:0007063)3.00219738
74pentose-phosphate shunt (GO:0006098)2.99694393
75regulation of hippo signaling (GO:0035330)2.99598020
76purine nucleobase biosynthetic process (GO:0009113)2.97107281
77DNA topological change (GO:0006265)2.96158384
78SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.95363930
79amino acid activation (GO:0043038)2.94467583
80tRNA aminoacylation (GO:0043039)2.94467583
81translational initiation (GO:0006413)2.94174922
82pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.93955479
83DNA ligation (GO:0006266)2.92148785
84regulation of translational elongation (GO:0006448)2.91193113
85pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.91185899
86regulation of histone H3-K9 methylation (GO:0051570)2.90912804
87positive regulation of SMAD protein import into nucleus (GO:0060391)2.90886825
88nuclear envelope organization (GO:0006998)2.89479922
89negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.89116161
90mitotic chromosome condensation (GO:0007076)2.89013153
91mitochondrial fusion (GO:0008053)2.88655261
92positive regulation of chromosome segregation (GO:0051984)2.87942458
93rRNA processing (GO:0006364)2.87172417
94cotranslational protein targeting to membrane (GO:0006613)2.86360526
95protein targeting to ER (GO:0045047)2.85372866
96telomere maintenance via telomere lengthening (GO:0010833)2.83659294
97translational elongation (GO:0006414)2.83490781
98viral life cycle (GO:0019058)2.83124075
99ATP-dependent chromatin remodeling (GO:0043044)2.83019548
100positive regulation of RNA splicing (GO:0033120)2.82370417
101mitotic metaphase plate congression (GO:0007080)2.81668868
102anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.80658247
103NADPH regeneration (GO:0006740)2.80508050
104planar cell polarity pathway involved in neural tube closure (GO:0090179)2.80438745
105* peptidyl-arginine N-methylation (GO:0035246)2.80409392
106* peptidyl-arginine methylation (GO:0018216)2.80409392
107pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.80247990
108termination of RNA polymerase II transcription (GO:0006369)2.80240383
109* peptidyl-arginine omega-N-methylation (GO:0035247)2.78672989
110nucleobase biosynthetic process (GO:0046112)2.78620452
111regulation of DNA damage checkpoint (GO:2000001)2.78400573
112telomere maintenance via semi-conservative replication (GO:0032201)2.78016708
113deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.77984467
114mitotic sister chromatid cohesion (GO:0007064)2.77687099
115mRNA transport (GO:0051028)2.76779848
116regulation of protein heterodimerization activity (GO:0043497)2.76620312
117peptidyl-lysine dimethylation (GO:0018027)2.76585825
118regulation of RNA export from nucleus (GO:0046831)2.75372522
119histone H2A monoubiquitination (GO:0035518)2.74161200
120establishment or maintenance of monopolar cell polarity (GO:0061339)2.73682464
121establishment of monopolar cell polarity (GO:0061162)2.73682464
122histone H4-K12 acetylation (GO:0043983)2.73125388
123alternative mRNA splicing, via spliceosome (GO:0000380)2.73028372
124regulation of gene silencing (GO:0060968)2.71381959
125regulation of mRNA stability (GO:0043488)2.67965870
126regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.66935887
127chromatin assembly or disassembly (GO:0006333)2.65160526
128regulation of chromosome segregation (GO:0051983)2.64773076
129DNA conformation change (GO:0071103)2.64683986
130negative regulation of chromosome segregation (GO:0051985)2.63757298
131protein-DNA complex disassembly (GO:0032986)2.62767855
132nucleosome disassembly (GO:0006337)2.62767855
1333-UTR-mediated mRNA stabilization (GO:0070935)2.62615166
134ribosome assembly (GO:0042255)2.62483550
135ribosome biogenesis (GO:0042254)2.62110076
136regulation of spindle organization (GO:0090224)2.62082673
137intracellular estrogen receptor signaling pathway (GO:0030520)2.61340353
138regulation of SMAD protein import into nucleus (GO:0060390)2.60129759
139protein complex disassembly (GO:0043241)2.59569845
140ribosomal large subunit biogenesis (GO:0042273)2.58851073
141somatic hypermutation of immunoglobulin genes (GO:0016446)2.57417513
142somatic diversification of immune receptors via somatic mutation (GO:0002566)2.57417513
143ribosomal small subunit biogenesis (GO:0042274)2.56780275
144RNA export from nucleus (GO:0006405)2.56655590
145protein localization to chromosome (GO:0034502)2.56051251
146spliceosomal snRNP assembly (GO:0000387)2.55697681

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.12157094
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.94101524
3* MYC_18555785_ChIP-Seq_MESCs_Mouse3.88738161
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.34077609
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.23505855
6* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.14996429
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.94115837
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.89910673
9MYC_22102868_ChIP-Seq_BL_Human2.77429774
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.43551112
11XRN2_22483619_ChIP-Seq_HELA_Human2.25486427
12* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.24377138
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.18168486
14KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.15259297
15SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.14951813
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.14290155
17* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.12630405
18KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.07880407
19KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.07880407
20KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.07880407
21TP63_19390658_ChIP-ChIP_HaCaT_Human2.02903371
22NELFA_20434984_ChIP-Seq_ESCs_Mouse1.99284207
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.93698091
24POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.85931761
25* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.83896888
26E2F1_21310950_ChIP-Seq_MCF-7_Human1.82040079
27MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.80369033
28CIITA_25753668_ChIP-Seq_RAJI_Human1.71536582
29POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.70945183
30NANOG_18555785_ChIP-Seq_MESCs_Mouse1.69799229
31AR_21909140_ChIP-Seq_LNCAP_Human1.67196423
32YY1_21170310_ChIP-Seq_MESCs_Mouse1.66887999
33* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.65932361
34CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.65929917
35MYCN_18555785_ChIP-Seq_MESCs_Mouse1.63606796
36ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.62915421
37HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.60764134
38SOX2_18555785_ChIP-Seq_MESCs_Mouse1.60714042
39TCF3_18692474_ChIP-Seq_MEFs_Mouse1.60431879
40TTF2_22483619_ChIP-Seq_HELA_Human1.60419034
41ZNF263_19887448_ChIP-Seq_K562_Human1.59449808
42ETS1_20019798_ChIP-Seq_JURKAT_Human1.59194886
43GABP_17652178_ChIP-ChIP_JURKAT_Human1.58647046
44NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.57225192
45VDR_21846776_ChIP-Seq_THP-1_Human1.54864852
46ELF1_17652178_ChIP-ChIP_JURKAT_Human1.54026929
47ESR1_15608294_ChIP-ChIP_MCF-7_Human1.52749472
48TP63_17297297_ChIP-ChIP_HaCaT_Human1.52475317
49KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.50157673
50STAT6_21828071_ChIP-Seq_BEAS2B_Human1.47621385
51* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.45948002
52KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.45850266
53STAT3_1855785_ChIP-Seq_MESCs_Mouse1.44809948
54SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.42503269
55EST1_17652178_ChIP-ChIP_JURKAT_Human1.42211638
56SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.40348602
57* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.40269481
58* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.39437428
59CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.39032706
60ZFP281_27345836_Chip-Seq_ESCs_Mouse1.38614624
61KDM5A_27292631_Chip-Seq_BREAST_Human1.38088667
62* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.37813486
63CREB1_15753290_ChIP-ChIP_HEK293T_Human1.37763183
64PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.36323328
65SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.36282444
66NANOG_21062744_ChIP-ChIP_HESCs_Human1.35653774
67E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.34513108
68KLF4_18555785_ChIP-Seq_MESCs_Mouse1.34403089
69* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34059237
70* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.32779227
71THAP11_20581084_ChIP-Seq_MESCs_Mouse1.31027792
72POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.28605198
73TCF3_18692474_ChIP-Seq_MESCs_Mouse1.28077092
74* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27751604
75NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.26121956
76KDM2B_26808549_Chip-Seq_DND41_Human1.23986216
77ELK3_25401928_ChIP-Seq_HUVEC_Human1.21989530
78* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.21808643
79HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.21185964
80GABP_19822575_ChIP-Seq_HepG2_Human1.21011768
81DCP1A_22483619_ChIP-Seq_HELA_Human1.18487846
82HIF1A_21447827_ChIP-Seq_MCF-7_Human1.17830822
83SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.17256771
84TET1_21451524_ChIP-Seq_MESCs_Mouse1.17197079
85KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.16803656
86ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.15874777
87SALL1_21062744_ChIP-ChIP_HESCs_Human1.14760579
88TCF7_22412390_ChIP-Seq_EML_Mouse1.14416286
89POU5F1_16518401_ChIP-PET_MESCs_Mouse1.14105398
90HOXB4_20404135_ChIP-ChIP_EML_Mouse1.14074919
91TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.12553188
92* FOXP3_21729870_ChIP-Seq_TREG_Human1.12252865
93NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.11674490
94* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.11162687
95LXR_22292898_ChIP-Seq_THP-1_Human1.10989367
96SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.10654425
97CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.09657878
98OCT4_18692474_ChIP-Seq_MEFs_Mouse1.08396035
99SRY_22984422_ChIP-ChIP_TESTIS_Rat1.07905725
100SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.07578498
101VDR_23849224_ChIP-Seq_CD4+_Human1.06872370
102TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.06222686
103KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.04846301
104* SRF_21415370_ChIP-Seq_HL-1_Mouse1.04349402
105* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.03914822
106* FOXP1_21924763_ChIP-Seq_HESCs_Human1.00464598
107* CHD1_26751641_Chip-Seq_LNCaP_Human0.99975716
108NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.99939279
109SOX2_18692474_ChIP-Seq_MEFs_Mouse0.99929336
110HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.99035279
111JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.98696857
112TFEB_21752829_ChIP-Seq_HELA_Human0.98339695
113RACK7_27058665_Chip-Seq_MCF-7_Human0.97547387
114* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.96709941
115ATF3_27146783_Chip-Seq_COLON_Human0.96469908
116DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.96364838
117TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96251847
118FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.96118717
119SOX2_18692474_ChIP-Seq_MESCs_Mouse0.94636712
120CTCF_18555785_ChIP-Seq_MESCs_Mouse0.94514516
121EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93970767
122CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.93802180
123FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.93254046
124ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.93249612
125SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92701022
126PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92485570
127E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92200117
128TBX5_21415370_ChIP-Seq_HL-1_Mouse0.91619434
129P68_20966046_ChIP-Seq_HELA_Human0.91472141
130* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.91104545

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003111_abnormal_nucleus_morphology3.21310238
2MP0004957_abnormal_blastocyst_morpholog3.10729647
3MP0010030_abnormal_orbit_morphology3.06697850
4MP0010094_abnormal_chromosome_stability2.91763061
5MP0003693_abnormal_embryo_hatching2.75880620
6MP0003123_paternal_imprinting2.73188261
7MP0003077_abnormal_cell_cycle2.72194221
8MP0010352_gastrointestinal_tract_polyps2.59343881
9MP0000537_abnormal_urethra_morphology2.42300294
10MP0005076_abnormal_cell_differentiation2.39670956
11MP0008057_abnormal_DNA_replication2.36495151
12MP0003705_abnormal_hypodermis_morpholog2.36440863
13MP0001730_embryonic_growth_arrest2.22043199
14MP0000350_abnormal_cell_proliferation2.08537805
15MP0008007_abnormal_cellular_replicative2.04488882
16MP0004197_abnormal_fetal_growth/weight/2.02447920
17MP0002084_abnormal_developmental_patter2.01107865
18MP0009053_abnormal_anal_canal2.00402578
19MP0003121_genomic_imprinting1.97901197
20MP0008932_abnormal_embryonic_tissue1.96656879
21* MP0002085_abnormal_embryonic_tissue1.95453102
22MP0005380_embryogenesis_phenotype1.90587199
23MP0001672_abnormal_embryogenesis/_devel1.90587199
24MP0002653_abnormal_ependyma_morphology1.90265609
25MP0005451_abnormal_body_composition1.89136428
26MP0003119_abnormal_digestive_system1.79050111
27MP0001697_abnormal_embryo_size1.78909452
28MP0003890_abnormal_embryonic-extraembry1.77985866
29MP0004185_abnormal_adipocyte_glucose1.73582977
30MP0003984_embryonic_growth_retardation1.71514713
31MP0002088_abnormal_embryonic_growth/wei1.70246051
32MP0010307_abnormal_tumor_latency1.66094633
33MP0000733_abnormal_muscle_development1.65160236
34MP0003567_abnormal_fetal_cardiomyocyte1.60998969
35MP0002086_abnormal_extraembryonic_tissu1.60473512
36MP0008058_abnormal_DNA_repair1.57856751
37MP0005623_abnormal_meninges_morphology1.56408361
38* MP0002080_prenatal_lethality1.55417630
39MP0003122_maternal_imprinting1.55271141
40MP0000428_abnormal_craniofacial_morphol1.54890558
41MP0003283_abnormal_digestive_organ1.48530150
42MP0001849_ear_inflammation1.47595750
43MP0000566_synostosis1.46493294
44MP0003385_abnormal_body_wall1.45511514
45MP0006035_abnormal_mitochondrial_morpho1.42481693
46MP0001293_anophthalmia1.40508236
47MP0003718_maternal_effect1.38464463
48MP0003937_abnormal_limbs/digits/tail_de1.37113565
49MP0005501_abnormal_skin_physiology1.36363405
50MP0004233_abnormal_muscle_weight1.36085645
51MP0009278_abnormal_bone_marrow1.35974879
52MP0003941_abnormal_skin_development1.35038293
53MP0006292_abnormal_olfactory_placode1.33829940
54MP0003942_abnormal_urinary_system1.33250647
55MP0004133_heterotaxia1.31023137
56MP0009379_abnormal_foot_pigmentation1.29896169
57MP0002111_abnormal_tail_morphology1.27393676
58MP0003115_abnormal_respiratory_system1.26493867
59MP0002932_abnormal_joint_morphology1.25354289
60MP0000751_myopathy1.25234566
61MP0002697_abnormal_eye_size1.23630941
62MP0003935_abnormal_craniofacial_develop1.22371932
63MP0001661_extended_life_span1.21592623
64MP0000049_abnormal_middle_ear1.20795352
65MP0003566_abnormal_cell_adhesion1.17172801
66MP0009672_abnormal_birth_weight1.16166022
67MP0003861_abnormal_nervous_system1.15985974
68MP0000358_abnormal_cell_content/1.15679754
69MP0002254_reproductive_system_inflammat1.15513385
70MP0001346_abnormal_lacrimal_gland1.15021776
71MP0003755_abnormal_palate_morphology1.13216258
72MP0002249_abnormal_larynx_morphology1.12226906
73MP0003315_abnormal_perineum_morphology1.11777084
74MP0000534_abnormal_ureter_morphology1.10150171
75MP0002092_abnormal_eye_morphology1.10128875
76MP0003786_premature_aging1.09665962
77MP0002396_abnormal_hematopoietic_system1.09050784
78MP0009703_decreased_birth_body1.06758160
79MP0000432_abnormal_head_morphology1.06446015
80MP0004808_abnormal_hematopoietic_stem1.06082155
81MP0003221_abnormal_cardiomyocyte_apopto1.05662141
82MP0009697_abnormal_copulation1.05432138
83MP0002796_impaired_skin_barrier1.05106075
84MP0001727_abnormal_embryo_implantation1.04964883
85MP0004858_abnormal_nervous_system1.04592569
86MP0000313_abnormal_cell_death1.02963637
87MP0000490_abnormal_crypts_of1.02668481
88MP0002116_abnormal_craniofacial_bone0.99888228
89MP0000750_abnormal_muscle_regeneration0.99574549
90MP0002114_abnormal_axial_skeleton0.99558968
91MP0002925_abnormal_cardiovascular_devel0.99533024
92MP0002282_abnormal_trachea_morphology0.99456374
93MP0000678_abnormal_parathyroid_gland0.97424310
94MP0001286_abnormal_eye_development0.97407947
95MP0008877_abnormal_DNA_methylation0.95626535
96MP0001348_abnormal_lacrimal_gland0.95300615
97MP0008260_abnormal_autophagy0.94951509
98MP0001915_intracranial_hemorrhage0.92244854
99MP0000003_abnormal_adipose_tissue0.91781625
100MP0002938_white_spotting0.88784847
101MP0000747_muscle_weakness0.86943567
102MP0005384_cellular_phenotype0.86870173
103MP0002233_abnormal_nose_morphology0.86713185
104MP0008789_abnormal_olfactory_epithelium0.85531029
105MP0001529_abnormal_vocalization0.84689672
106MP0002019_abnormal_tumor_incidence0.84089294
107MP0000762_abnormal_tongue_morphology0.83094729
108MP0002081_perinatal_lethality0.83033042
109MP0008770_decreased_survivor_rate0.82928230
110MP0005330_cardiomyopathy0.82897523
111MP0005023_abnormal_wound_healing0.81607494
112MP0000579_abnormal_nail_morphology0.80314925
113MP0002877_abnormal_melanocyte_morpholog0.80039683
114MP0005621_abnormal_cell_physiology0.79334757
115MP0004087_abnormal_muscle_fiber0.78009686
116MP0000759_abnormal_skeletal_muscle0.77975801
117MP0005257_abnormal_intraocular_pressure0.77173693
118MP0009250_abnormal_appendicular_skeleto0.76936479
119MP0004272_abnormal_basement_membrane0.75848768
120MP0005508_abnormal_skeleton_morphology0.75278341
121MP0010630_abnormal_cardiac_muscle0.75113941
122MP0005187_abnormal_penis_morphology0.74843359
123MP0002089_abnormal_postnatal_growth/wei0.73127041
124MP0000703_abnormal_thymus_morphology0.72911720
125MP0000266_abnormal_heart_morphology0.72806284
126MP0003938_abnormal_ear_development0.72395875
127MP0008438_abnormal_cutaneous_collagen0.71767326
128MP0002751_abnormal_autonomic_nervous0.71685793
129MP0006036_abnormal_mitochondrial_physio0.70994935
130MP0005394_taste/olfaction_phenotype0.70904225
131MP0005499_abnormal_olfactory_system0.70904225
132MP0002234_abnormal_pharynx_morphology0.70158383
133MP0010234_abnormal_vibrissa_follicle0.69958716

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)3.78436402
2Microvesicular hepatic steatosis (HP:0001414)3.59332768
3Abnormality of cells of the erythroid lineage (HP:0012130)3.44159268
4Progressive muscle weakness (HP:0003323)3.32638209
5Abnormal number of erythroid precursors (HP:0012131)3.30531258
6Renal duplication (HP:0000075)3.28801995
7Selective tooth agenesis (HP:0001592)3.20303879
8Multiple enchondromatosis (HP:0005701)3.16917707
9Astrocytoma (HP:0009592)3.07983997
10Abnormality of the astrocytes (HP:0100707)3.07983997
11Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.98638215
12Short 4th metacarpal (HP:0010044)2.98638215
13Hyperacusis (HP:0010780)2.91979732
14Increased nuchal translucency (HP:0010880)2.79656057
15Medulloblastoma (HP:0002885)2.73117998
16Abnormality of glycolysis (HP:0004366)2.68426194
17Spastic diplegia (HP:0001264)2.66815843
18Colon cancer (HP:0003003)2.57567266
19Ragged-red muscle fibers (HP:0003200)2.56566083
20Abnormality of the labia minora (HP:0012880)2.54186301
21Cholecystitis (HP:0001082)2.52681456
22Abnormal gallbladder physiology (HP:0012438)2.52681456
23Abnormal number of incisors (HP:0011064)2.46605933
24Pseudobulbar signs (HP:0002200)2.46334068
25Rib fusion (HP:0000902)2.46001819
26Shallow orbits (HP:0000586)2.42963916
27Missing ribs (HP:0000921)2.41381201
28Protrusio acetabuli (HP:0003179)2.40224295
29Glioma (HP:0009733)2.38854702
30Proximal placement of thumb (HP:0009623)2.38084842
31Abnormality of the 4th metacarpal (HP:0010012)2.38049536
32Deviation of the thumb (HP:0009603)2.37097695
33Aplasia/Hypoplasia of the sacrum (HP:0008517)2.35011374
34Broad distal phalanx of finger (HP:0009836)2.33740388
35Rough bone trabeculation (HP:0100670)2.27252974
36Centrally nucleated skeletal muscle fibers (HP:0003687)2.24780136
37Cortical dysplasia (HP:0002539)2.22650508
38Increased serum pyruvate (HP:0003542)2.18672314
39Overriding aorta (HP:0002623)2.18424298
40Patellar aplasia (HP:0006443)2.16550236
41Reticulocytopenia (HP:0001896)2.16434544
42Elfin facies (HP:0004428)2.16424267
43Progressive external ophthalmoplegia (HP:0000590)2.15026949
44Neoplasm of striated muscle (HP:0009728)2.14807386
45Abnormality of reticulocytes (HP:0004312)2.13309717
46Abnormality of the calcaneus (HP:0008364)2.13188151
47Achilles tendon contracture (HP:0001771)2.12038515
48Renovascular hypertension (HP:0100817)2.10449222
49Atresia of the external auditory canal (HP:0000413)2.09966325
50Neoplasm of the oral cavity (HP:0100649)2.09334525
51Aplasia/Hypoplasia of the patella (HP:0006498)2.08951772
52Pelvic girdle muscle weakness (HP:0003749)2.08725410
53Rhabdomyosarcoma (HP:0002859)2.08584401
54Distal lower limb amyotrophy (HP:0008944)2.05688847
55Bowel diverticulosis (HP:0005222)2.05483555
56High anterior hairline (HP:0009890)2.05341947
57Trismus (HP:0000211)2.02723505
58Malignant gastrointestinal tract tumors (HP:0006749)2.00455031
59Gastrointestinal carcinoma (HP:0002672)2.00455031
60Birth length less than 3rd percentile (HP:0003561)2.00422585
61Long palpebral fissure (HP:0000637)1.98937629
62Increased density of long bones (HP:0006392)1.98733677
63Facial cleft (HP:0002006)1.97035728
64Pointed chin (HP:0000307)1.95385641
65Aplasia/hypoplasia of the humerus (HP:0006507)1.95368364
66Shoulder girdle muscle weakness (HP:0003547)1.95114856
67Myopathic facies (HP:0002058)1.94755996
68Macrocytic anemia (HP:0001972)1.93086574
69Broad thumb (HP:0011304)1.92489358
70Basal cell carcinoma (HP:0002671)1.92183738
71Absent radius (HP:0003974)1.91606855
72Horseshoe kidney (HP:0000085)1.91352592
73Esophageal atresia (HP:0002032)1.90209936
74Abnormality of abdominal situs (HP:0011620)1.89078348
75Abdominal situs inversus (HP:0003363)1.89078348
76Glossoptosis (HP:0000162)1.88776203
77Squamous cell carcinoma (HP:0002860)1.87971864
78Flat cornea (HP:0007720)1.87837024
79Supernumerary ribs (HP:0005815)1.87495621
80Trigonocephaly (HP:0000243)1.86146301
81Bladder diverticulum (HP:0000015)1.85887982
82Vertebral fusion (HP:0002948)1.85733100
83Short humerus (HP:0005792)1.85631229
84Angiofibromas (HP:0010615)1.84753044
85Adenoma sebaceum (HP:0009720)1.84753044
86Skull defect (HP:0001362)1.83466765
87Skin tags (HP:0010609)1.82846257
88Limb-girdle muscle atrophy (HP:0003797)1.82512715
89Generalized hypotonia (HP:0001290)1.82378428
90Abnormality of the diencephalon (HP:0010662)1.82278804
91Aplasia involving forearm bones (HP:0009822)1.80878047
92Absent forearm bone (HP:0003953)1.80878047
93Abnormality of the umbilical cord (HP:0010881)1.79634952
94Spina bifida occulta (HP:0003298)1.79061631
95Cerebral aneurysm (HP:0004944)1.78744387
96Preauricular skin tag (HP:0000384)1.77309730
97Facial hemangioma (HP:0000329)1.77000227
98Hypoplasia of the capital femoral epiphysis (HP:0003090)1.76904056
99Ulnar bowing (HP:0003031)1.76868696
100Back pain (HP:0003418)1.75171217
101Insomnia (HP:0100785)1.74925889
102Genu recurvatum (HP:0002816)1.74823503
103Chromosomal breakage induced by crosslinking agents (HP:0003221)1.74374690
104Duplication of thumb phalanx (HP:0009942)1.74317846
105Aplastic anemia (HP:0001915)1.73869421
106Broad palm (HP:0001169)1.73835092
107Breast hypoplasia (HP:0003187)1.73785574
108Volvulus (HP:0002580)1.72836794
109Megalocornea (HP:0000485)1.72730448
110Premature ovarian failure (HP:0008209)1.72381282
111Supernumerary bones of the axial skeleton (HP:0009144)1.72318454
112Increased intramyocellular lipid droplets (HP:0012240)1.71679176
113Wrist flexion contracture (HP:0001239)1.71674123
114Short 5th finger (HP:0009237)1.71500595
115Abnormality of the Achilles tendon (HP:0005109)1.70405966
116Abnormality of the hip-girdle musculature (HP:0001445)1.69903765
117Abnormality of the musculature of the pelvis (HP:0001469)1.69903765
118Neoplasm of the pancreas (HP:0002894)1.69818542
119Chromsome breakage (HP:0040012)1.68358470
120Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.67685399
121Absent epiphyses (HP:0010577)1.67685399
122Shawl scrotum (HP:0000049)1.67585882
123Testicular atrophy (HP:0000029)1.67551594
124Aplasia/Hypoplasia of the sternum (HP:0006714)1.67088740
125Adducted thumb (HP:0001181)1.67087562
126Fibroma (HP:0010614)1.67082030
127Deviation of the hallux (HP:0010051)1.66608368
128Nephroblastoma (Wilms tumor) (HP:0002667)1.66344192
129Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.65723874
130Supernumerary spleens (HP:0009799)1.65102013
131Broad phalanges of the hand (HP:0009768)1.64889797
132Abnormality of the anterior horn cell (HP:0006802)1.64058710
133Degeneration of anterior horn cells (HP:0002398)1.64058710
134High pitched voice (HP:0001620)1.63525617
135Hallux valgus (HP:0001822)1.63042384
136Fibrous tissue neoplasm (HP:0012316)1.62687096
137Overlapping toe (HP:0001845)1.62236456
138Long eyelashes (HP:0000527)1.62181406
139Tracheoesophageal fistula (HP:0002575)1.60966757
140Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.60779353
141Decreased activity of mitochondrial respiratory chain (HP:0008972)1.60779353
142Reticulocytosis (HP:0001923)1.60689051
143Calcaneovalgus deformity (HP:0001848)1.60494224
144Secondary amenorrhea (HP:0000869)1.60491916
145Reduced antithrombin III activity (HP:0001976)1.60375768
146Pallor (HP:0000980)1.60308255
147Type I transferrin isoform profile (HP:0003642)1.60018558
148Ankle contracture (HP:0006466)1.59740054
149Meckel diverticulum (HP:0002245)1.58387367
150Difficulty climbing stairs (HP:0003551)1.57658298
151Abnormality of the lower motor neuron (HP:0002366)1.57594606
152Abnormality of the ileum (HP:0001549)1.57242521
153Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.57105427
154Partial duplication of thumb phalanx (HP:0009944)1.57075117
155Urethral obstruction (HP:0000796)1.56846134
156Abnormal trabecular bone morphology (HP:0100671)1.56733656
157Premature skin wrinkling (HP:0100678)1.56547578
158Lower limb amyotrophy (HP:0007210)1.56519722
159Premature rupture of membranes (HP:0001788)1.56331859
160Microretrognathia (HP:0000308)1.54489838
161Abnormal lung lobation (HP:0002101)1.54255626
162Exercise intolerance (HP:0003546)1.53959284
163Deep palmar crease (HP:0006191)1.53680260
164Upper limb muscle weakness (HP:0003484)1.53420119
165Increased connective tissue (HP:0009025)1.53412645
166Abnormality of the preputium (HP:0100587)1.52670292
167Poikiloderma (HP:0001029)1.51982791
168Deformed tarsal bones (HP:0008119)1.51041594
169Increased muscle lipid content (HP:0009058)1.49938237

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.00028811
2SMG13.96169787
3CDK123.90737045
4EEF2K3.77143161
5CDC73.42634125
6MAP3K103.08831863
7PKN22.95415472
8TRIB32.70776255
9BUB12.43972746
10NEK22.36770810
11NEK12.15607848
12RPS6KB22.13210422
13WEE12.06879953
14TSSK62.06146538
15TTK1.99669332
16PASK1.99581686
17ALK1.99429003
18ICK1.90162429
19MKNK11.87469250
20EPHA21.81659633
21PBK1.81548851
22LATS21.76420651
23CDK71.71897108
24PAK41.68006053
25BRD41.61830068
26TAF11.60413973
27TTN1.59258516
28IRAK31.58715273
29TESK21.57757260
30MKNK21.56599488
31PDGFRA1.51599699
32VRK11.50887041
33KDR1.50849049
34ZAK1.48878805
35SRPK11.44519540
36NME11.42671150
37CDK41.40496903
38MAP3K81.36799261
39PLK11.32596046
40MTOR1.27967779
41ATR1.26995231
42CHEK11.26086660
43TGFBR11.23904162
44BMX1.20802815
45BCKDK1.20157643
46LATS11.19038536
47STK101.16689871
48PTK61.15806023
49PAK21.15252278
50SCYL21.13640219
51CDK81.12352982
52CDK61.11507995
53ARAF1.10793076
54DDR21.06832785
55AURKB1.06172550
56LRRK21.05798672
57TYRO31.05466612
58SIK11.05138361
59CHEK21.00907070
60PRPF4B1.00236429
61PIM20.98561038
62STK160.96685323
63CDK20.95345932
64FGFR10.94601066
65TLK10.92764254
66PLK30.91818758
67FGFR40.90326202
68ILK0.89512023
69DAPK10.89148662
70CDK190.88639694
71BRAF0.86367822
72AURKA0.85914215
73EPHB20.84572010
74DYRK30.82544964
75ATM0.81170203
76AKT20.79671344
77TESK10.79344439
78DAPK30.78483139
79RIPK10.73945656
80PLK40.73530118
81TAOK20.73340052
82CSNK1G30.71105583
83RPS6KA40.70169499
84PAK10.68813652
85STK30.68371114
86CDK10.68293837
87LIMK10.67899233
88CSNK1E0.65439525
89RPS6KA50.62679630
90DYRK20.62035279
91FLT30.61722126
92STK40.59343282
93KSR10.59013109
94CDK90.58256041
95SIK20.57542500
96PTK20.55800358
97UHMK10.55363979
98PRKCI0.54646205
99CSNK1A1L0.54074625
100EIF2AK20.52263767
101PIM10.51346111
102PRKDC0.50774276
103CSNK1D0.49927003
104MAP3K110.49457286
105PRKD30.48892939
106EIF2AK10.48815344
107GRK60.47416488
108CSNK1G10.45372086
109CSNK2A20.45316473
110RPS6KA10.44440238
111BRSK10.43724065
112CDK11A0.43656199
113NTRK10.43615312
114MAPK140.43337997
115TAOK10.42177634
116CDK150.41568152
117LMTK20.40854040
118AKT10.40727884
119MAPK110.40178136
120ACVR1B0.39673875
121CLK10.39158448
122MAP2K70.39118862
123ERBB40.38859568
124CDK140.38804480
125CSNK2A10.37575464
126PNCK0.37477234
127PAK60.37360657
128CDK180.37262654
129CCNB10.35868644
130CDC42BPA0.35703291
131PDGFRB0.35522577
132NME20.35315211
133BRSK20.34853906
134DMPK0.34233358
135GSK3B0.33767589
136DYRK1B0.33480578
137MAPK90.32867808
138MAPK10.32672619
139MAP2K20.32219869

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.59977175
2Spliceosome_Homo sapiens_hsa030403.35239172
3Mismatch repair_Homo sapiens_hsa034303.28572936
4RNA transport_Homo sapiens_hsa030133.03381578
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.85553436
6One carbon pool by folate_Homo sapiens_hsa006702.62460359
7Cell cycle_Homo sapiens_hsa041102.54598360
8mRNA surveillance pathway_Homo sapiens_hsa030152.49972682
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.33815567
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.33074417
11Base excision repair_Homo sapiens_hsa034102.32575301
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.26145979
13Ribosome_Homo sapiens_hsa030102.23414752
14Nucleotide excision repair_Homo sapiens_hsa034202.15414290
15Sulfur relay system_Homo sapiens_hsa041221.91567169
16Pentose phosphate pathway_Homo sapiens_hsa000301.89776429
17Basal cell carcinoma_Homo sapiens_hsa052171.84226410
18Carbon metabolism_Homo sapiens_hsa012001.82782074
19Homologous recombination_Homo sapiens_hsa034401.72204532
20Hippo signaling pathway_Homo sapiens_hsa043901.65925130
21p53 signaling pathway_Homo sapiens_hsa041151.55948596
22MicroRNAs in cancer_Homo sapiens_hsa052061.55826105
23RNA polymerase_Homo sapiens_hsa030201.49965411
24Notch signaling pathway_Homo sapiens_hsa043301.48483406
25Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.48232728
26Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.46125595
27Fanconi anemia pathway_Homo sapiens_hsa034601.45821102
28RNA degradation_Homo sapiens_hsa030181.45533087
29Hedgehog signaling pathway_Homo sapiens_hsa043401.44818955
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.42621852
31Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.41159072
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.38928008
33Chronic myeloid leukemia_Homo sapiens_hsa052201.38252634
34Bladder cancer_Homo sapiens_hsa052191.29971926
35Viral carcinogenesis_Homo sapiens_hsa052031.28179679
36Colorectal cancer_Homo sapiens_hsa052101.28052023
37HTLV-I infection_Homo sapiens_hsa051661.26687409
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.24466417
39Fructose and mannose metabolism_Homo sapiens_hsa000511.23790570
40Adherens junction_Homo sapiens_hsa045201.23004914
41Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.18327403
42Central carbon metabolism in cancer_Homo sapiens_hsa052301.16711509
43Small cell lung cancer_Homo sapiens_hsa052221.16267408
44Oocyte meiosis_Homo sapiens_hsa041141.15387684
45Pyruvate metabolism_Homo sapiens_hsa006201.15235402
46mTOR signaling pathway_Homo sapiens_hsa041501.13191457
47Parkinsons disease_Homo sapiens_hsa050121.10425165
48Viral myocarditis_Homo sapiens_hsa054161.08320981
49Proteoglycans in cancer_Homo sapiens_hsa052051.08042697
50Thyroid cancer_Homo sapiens_hsa052161.07954542
51Pyrimidine metabolism_Homo sapiens_hsa002401.07149533
52Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.04402467
53TGF-beta signaling pathway_Homo sapiens_hsa043501.04048959
54Epstein-Barr virus infection_Homo sapiens_hsa051691.02837300
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.01149226
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.00906746
57Basal transcription factors_Homo sapiens_hsa030221.00817524
58Endometrial cancer_Homo sapiens_hsa052131.00440624
59Non-homologous end-joining_Homo sapiens_hsa034500.98438926
60Wnt signaling pathway_Homo sapiens_hsa043100.97835733
61Huntingtons disease_Homo sapiens_hsa050160.95727197
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.95043974
63Tight junction_Homo sapiens_hsa045300.92097590
64N-Glycan biosynthesis_Homo sapiens_hsa005100.90914814
65Transcriptional misregulation in cancer_Homo sapiens_hsa052020.90183150
66Galactose metabolism_Homo sapiens_hsa000520.90090211
67Non-small cell lung cancer_Homo sapiens_hsa052230.86250927
68Vitamin B6 metabolism_Homo sapiens_hsa007500.85117358
69Lysine degradation_Homo sapiens_hsa003100.85088969
70Pathways in cancer_Homo sapiens_hsa052000.84048373
71Focal adhesion_Homo sapiens_hsa045100.80621776
72Proteasome_Homo sapiens_hsa030500.80594741
73Folate biosynthesis_Homo sapiens_hsa007900.80273195
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80000638
75Oxidative phosphorylation_Homo sapiens_hsa001900.79542466
76Systemic lupus erythematosus_Homo sapiens_hsa053220.79004614
77Antigen processing and presentation_Homo sapiens_hsa046120.78287929
78Biosynthesis of amino acids_Homo sapiens_hsa012300.78130740
79Fatty acid elongation_Homo sapiens_hsa000620.77482285
80Herpes simplex infection_Homo sapiens_hsa051680.74770152
81Acute myeloid leukemia_Homo sapiens_hsa052210.73092274
82Steroid biosynthesis_Homo sapiens_hsa001000.71046384
83HIF-1 signaling pathway_Homo sapiens_hsa040660.71036930
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.70986686
85Renal cell carcinoma_Homo sapiens_hsa052110.69926334
86Melanoma_Homo sapiens_hsa052180.68536933
87Glioma_Homo sapiens_hsa052140.67206500
88Prostate cancer_Homo sapiens_hsa052150.66704476
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64811661
90Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.64752652
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64626160
92VEGF signaling pathway_Homo sapiens_hsa043700.64607670
93Cyanoamino acid metabolism_Homo sapiens_hsa004600.62633948
94AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61727348
95Pancreatic cancer_Homo sapiens_hsa052120.61683237
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61315115
97Apoptosis_Homo sapiens_hsa042100.59710931
98Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57963234
99Hepatitis B_Homo sapiens_hsa051610.57766531
100Shigellosis_Homo sapiens_hsa051310.57691703
101Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56549985
102Alcoholism_Homo sapiens_hsa050340.56359329
103ECM-receptor interaction_Homo sapiens_hsa045120.52268077
104PI3K-Akt signaling pathway_Homo sapiens_hsa041510.51984530
105Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51961031
106Leukocyte transendothelial migration_Homo sapiens_hsa046700.51807912
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51749098
108Arginine and proline metabolism_Homo sapiens_hsa003300.51340416
109Glutathione metabolism_Homo sapiens_hsa004800.51069242
110Alzheimers disease_Homo sapiens_hsa050100.50347121
111Axon guidance_Homo sapiens_hsa043600.48214182
112Estrogen signaling pathway_Homo sapiens_hsa049150.48166945
113Melanogenesis_Homo sapiens_hsa049160.46815774
114Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.45990021
115Rap1 signaling pathway_Homo sapiens_hsa040150.43106173
116AMPK signaling pathway_Homo sapiens_hsa041520.42627014
117ErbB signaling pathway_Homo sapiens_hsa040120.42136793
118Legionellosis_Homo sapiens_hsa051340.39496019
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39380360
120Insulin signaling pathway_Homo sapiens_hsa049100.37011428
121Gap junction_Homo sapiens_hsa045400.36820332
122Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.36453598
123Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.35672413
124Cardiac muscle contraction_Homo sapiens_hsa042600.35245245
125Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35121859
126Metabolic pathways_Homo sapiens_hsa011000.34698258
127T cell receptor signaling pathway_Homo sapiens_hsa046600.34109692
128Purine metabolism_Homo sapiens_hsa002300.34056001
129Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33744896
130Prolactin signaling pathway_Homo sapiens_hsa049170.31105065
131Dilated cardiomyopathy_Homo sapiens_hsa054140.30655667
132Selenocompound metabolism_Homo sapiens_hsa004500.30196939
133Arginine biosynthesis_Homo sapiens_hsa002200.30143746
134Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.30017663
135Fatty acid metabolism_Homo sapiens_hsa012120.29433585
136Vibrio cholerae infection_Homo sapiens_hsa051100.27822948
137Phenylalanine metabolism_Homo sapiens_hsa003600.27606854
138Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.24897763
139Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.23591232

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