PRMT1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of B cell receptor signaling pathway (GO:0050855)4.53218374
2negative regulation by host of viral transcription (GO:0043922)4.25642757
3preassembly of GPI anchor in ER membrane (GO:0016254)4.14997431
4C4-dicarboxylate transport (GO:0015740)4.14822664
5DNA deamination (GO:0045006)3.88540110
6negative regulation of T cell apoptotic process (GO:0070233)3.83866992
7cytidine metabolic process (GO:0046087)3.82101985
8cytidine catabolic process (GO:0006216)3.82101985
9cytidine deamination (GO:0009972)3.82101985
10mannosylation (GO:0097502)3.76504217
11positive T cell selection (GO:0043368)3.71205044
12regulation of alpha-beta T cell proliferation (GO:0046640)3.65893383
13regulation of T cell receptor signaling pathway (GO:0050856)3.63371325
14positive regulation of granulocyte differentiation (GO:0030854)3.50770753
15T cell migration (GO:0072678)3.48574586
16signal peptide processing (GO:0006465)3.46645538
17negative regulation of calcium ion transport into cytosol (GO:0010523)3.32326958
18regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.30309319
19T cell receptor signaling pathway (GO:0050852)3.25831333
20GPI anchor biosynthetic process (GO:0006506)3.25652691
21negative T cell selection (GO:0043383)3.23570011
22pyrimidine ribonucleoside catabolic process (GO:0046133)3.23331185
23DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.20984266
24positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.20401770
25signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.14350220
26intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.14350220
27GPI anchor metabolic process (GO:0006505)3.14061452
28righting reflex (GO:0060013)3.13618492
29positive regulation of calcium-mediated signaling (GO:0050850)3.12861159
30RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.12336172
31signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.10634576
32signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.10634576
33signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.10634576
34iron-sulfur cluster assembly (GO:0016226)3.10430061
35metallo-sulfur cluster assembly (GO:0031163)3.10430061
36cell wall macromolecule catabolic process (GO:0016998)3.09043469
37regulation of T cell tolerance induction (GO:0002664)3.06910512
38cell wall macromolecule metabolic process (GO:0044036)3.04404889
39neural tube formation (GO:0001841)3.04126102
40DNA demethylation (GO:0080111)3.03531091
41peptidyl-histidine modification (GO:0018202)3.02114939
42positive regulation of tolerance induction (GO:0002645)2.99074604
43signal transduction involved in cell cycle checkpoint (GO:0072395)2.98169337
44modulation by host of symbiont transcription (GO:0052472)2.97599368
45modulation by host of viral transcription (GO:0043921)2.97599368
46organelle disassembly (GO:1903008)2.97045355
47signal transduction involved in DNA damage checkpoint (GO:0072422)2.95348237
48signal transduction involved in DNA integrity checkpoint (GO:0072401)2.95348237
49reflex (GO:0060004)2.95306723
50negative regulation of alpha-beta T cell activation (GO:0046636)2.94977000
51negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.94214397
52T cell costimulation (GO:0031295)2.92969622
53negative regulation of lymphocyte apoptotic process (GO:0070229)2.92143022
54protein complex biogenesis (GO:0070271)2.92041245
55regulation of cellular amino acid metabolic process (GO:0006521)2.91987492
56interferon-gamma production (GO:0032609)2.91212861
57regulation of lymphocyte chemotaxis (GO:1901623)2.91160731
58mitochondrial respiratory chain complex I assembly (GO:0032981)2.89903850
59NADH dehydrogenase complex assembly (GO:0010257)2.89903850
60mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.89903850
61lymphocyte costimulation (GO:0031294)2.88633356
62regulation of relaxation of muscle (GO:1901077)2.88318912
63negative regulation of sequestering of calcium ion (GO:0051283)2.88093702
64release of sequestered calcium ion into cytosol (GO:0051209)2.88093702
65positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.87761889
66proteasome assembly (GO:0043248)2.84869735
67modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)2.83984083
68flavonoid metabolic process (GO:0009812)2.81512317
69snRNA transcription (GO:0009301)2.77846471
70rRNA catabolic process (GO:0016075)2.75536616
71histone mRNA metabolic process (GO:0008334)2.75316301
72positive regulation of macrophage differentiation (GO:0045651)2.73427225
73peptidyl-arginine omega-N-methylation (GO:0035247)2.72221671
74mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.72003425
75positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.72003425
76necroptotic process (GO:0070266)2.70502709
77regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.70491626
78DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.68996252
79negative regulation of B cell proliferation (GO:0030889)2.67751121
80ribonucleoprotein complex disassembly (GO:0032988)2.65841747
81positive regulation of cell cycle arrest (GO:0071158)2.65387280
82histone mRNA catabolic process (GO:0071044)2.64173188
83regulation of calcium-mediated signaling (GO:0050848)2.62002566
84antigen receptor-mediated signaling pathway (GO:0050851)2.61921542
85branched-chain amino acid catabolic process (GO:0009083)2.60964255
86positive regulation of uterine smooth muscle contraction (GO:0070474)2.60963653
87negative regulation of interleukin-10 production (GO:0032693)2.58366309
88mitochondrial respiratory chain complex assembly (GO:0033108)2.57983325
89Arp2/3 complex-mediated actin nucleation (GO:0034314)2.57679189
90actin nucleation (GO:0045010)2.57473741
91positive regulation of T cell chemotaxis (GO:0010820)2.54918374
92regulation of T cell chemotaxis (GO:0010819)2.54918374
93negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.54708185
94regulation of B cell differentiation (GO:0045577)2.54335629
95regulation of tolerance induction (GO:0002643)2.54190615
96positive regulation of interleukin-8 secretion (GO:2000484)2.53598778
97transcription elongation from RNA polymerase I promoter (GO:0006362)2.51796858
98dentate gyrus development (GO:0021542)2.51306428
99T cell selection (GO:0045058)2.50988443
100arginine catabolic process (GO:0006527)2.47376473

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.76196750
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.91380146
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.41197610
4IGF1R_20145208_ChIP-Seq_DFB_Human3.31791852
5ZNF274_21170338_ChIP-Seq_K562_Hela3.27379503
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.26274091
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.14825959
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.14364898
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.61590348
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.58705736
11VDR_23849224_ChIP-Seq_CD4+_Human2.47894569
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.40850169
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.37540161
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.32071009
15ELK1_19687146_ChIP-ChIP_HELA_Human2.23878446
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.19283168
17IRF8_21731497_ChIP-ChIP_J774_Mouse2.13891887
18VDR_22108803_ChIP-Seq_LS180_Human2.08957845
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.08629944
20EWS_26573619_Chip-Seq_HEK293_Human2.07667063
21CIITA_25753668_ChIP-Seq_RAJI_Human2.07370357
22POU3F2_20337985_ChIP-ChIP_501MEL_Human2.06613817
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.05536395
24ELF1_17652178_ChIP-ChIP_JURKAT_Human1.89217030
25ER_23166858_ChIP-Seq_MCF-7_Human1.82739870
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.82087143
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.78636430
28MYB_26560356_Chip-Seq_TH2_Human1.74438157
29HOXB4_20404135_ChIP-ChIP_EML_Mouse1.73056473
30PADI4_21655091_ChIP-ChIP_MCF-7_Human1.72368990
31FUS_26573619_Chip-Seq_HEK293_Human1.69155894
32PCGF2_27294783_Chip-Seq_NPCs_Mouse1.68573391
33NOTCH1_21737748_ChIP-Seq_TLL_Human1.66430947
34JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.64359490
35RUNX_20019798_ChIP-Seq_JUKART_Human1.64321965
36IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.63599754
37CBP_20019798_ChIP-Seq_JUKART_Human1.63599754
38TAF15_26573619_Chip-Seq_HEK293_Human1.54372022
39KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.53789501
40FOXP3_21729870_ChIP-Seq_TREG_Human1.53318877
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.52302422
42RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.48612689
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48607543
44PCGF2_27294783_Chip-Seq_ESCs_Mouse1.48226035
45ETS1_20019798_ChIP-Seq_JURKAT_Human1.44755464
46P300_19829295_ChIP-Seq_ESCs_Human1.44142835
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40897330
48CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.38603537
49MYC_18940864_ChIP-ChIP_HL60_Human1.38326620
50GATA3_26560356_Chip-Seq_TH2_Human1.38319755
51EGR1_23403033_ChIP-Seq_LIVER_Mouse1.37199851
52UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36182528
53ZFP57_27257070_Chip-Seq_ESCs_Mouse1.35705347
54AR_20517297_ChIP-Seq_VCAP_Human1.31173398
55SRF_21415370_ChIP-Seq_HL-1_Mouse1.30934845
56GATA3_27048872_Chip-Seq_THYMUS_Human1.30254742
57GBX2_23144817_ChIP-Seq_PC3_Human1.29510460
58MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27790068
59CREB1_15753290_ChIP-ChIP_HEK293T_Human1.23134630
60MYB_26560356_Chip-Seq_TH1_Human1.19653320
61BCAT_22108803_ChIP-Seq_LS180_Human1.18969389
62GATA1_22025678_ChIP-Seq_K562_Human1.18638202
63SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.18603645
64GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.18230974
65FOXA1_21572438_ChIP-Seq_LNCaP_Human1.18168301
66SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16302519
67TP63_19390658_ChIP-ChIP_HaCaT_Human1.16248453
68E2F4_17652178_ChIP-ChIP_JURKAT_Human1.13804424
69MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11344614
70SOX2_19829295_ChIP-Seq_ESCs_Human1.10683605
71NANOG_19829295_ChIP-Seq_ESCs_Human1.10683605
72TP53_22573176_ChIP-Seq_HFKS_Human1.10588322
73EZH2_27294783_Chip-Seq_NPCs_Mouse1.09412684
74POU5F1_16153702_ChIP-ChIP_HESCs_Human1.08792037
75FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.08755588
76SALL4_22934838_ChIP-ChIP_CD34+_Human1.08153044
77FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.06468446
78NFE2_27457419_Chip-Seq_LIVER_Mouse1.04247640
79FLI1_21867929_ChIP-Seq_TH2_Mouse1.03998411
80PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.00436600
81KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99548066
82GABP_19822575_ChIP-Seq_HepG2_Human0.97210515
83STAT4_19710469_ChIP-ChIP_TH1__Mouse0.97135576
84SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.97096988
85STAT3_23295773_ChIP-Seq_U87_Human0.96714471
86STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.96151091
87CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95931810
88AR_25329375_ChIP-Seq_VCAP_Human0.95685201
89GATA3_26560356_Chip-Seq_TH1_Human0.94437313
90HTT_18923047_ChIP-ChIP_STHdh_Human0.93843942
91TCF4_22108803_ChIP-Seq_LS180_Human0.93427167
92PRDM14_20953172_ChIP-Seq_ESCs_Human0.92353001
93FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.90550318
94SMAD4_21799915_ChIP-Seq_A2780_Human0.90148301
95SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89943004
96EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.89775208
97EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.89518580
98OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87345540
99PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.85770210
100TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.85546878

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology4.03029146
2MP0005671_abnormal_response_to3.92489029
3MP0001984_abnormal_olfaction3.64216271
4MP0001835_abnormal_antigen_presentation3.46116122
5MP0002653_abnormal_ependyma_morphology3.14062737
6MP0008057_abnormal_DNA_replication3.08020460
7MP0006072_abnormal_retinal_apoptosis2.81290660
8MP0008058_abnormal_DNA_repair2.45300217
9MP0003880_abnormal_central_pattern2.36694160
10MP0006276_abnormal_autonomic_nervous2.20197921
11MP0010386_abnormal_urinary_bladder2.14899920
12MP0008961_abnormal_basal_metabolism2.12041934
13MP0001986_abnormal_taste_sensitivity2.07914322
14MP0002751_abnormal_autonomic_nervous2.04952407
15MP0005551_abnormal_eye_electrophysiolog1.99288831
16MP0003786_premature_aging1.78572944
17MP0001529_abnormal_vocalization1.77651406
18MP0006082_CNS_inflammation1.74878767
19MP0005253_abnormal_eye_physiology1.74819852
20MP0001800_abnormal_humoral_immune1.71705756
21MP0002166_altered_tumor_susceptibility1.70892481
22MP0008995_early_reproductive_senescence1.53964225
23MP0005408_hypopigmentation1.52850301
24MP0009785_altered_susceptibility_to1.51879518
25MP0002723_abnormal_immune_serum1.51772710
26MP0000703_abnormal_thymus_morphology1.49489454
27MP0001819_abnormal_immune_cell1.39320996
28MP0005075_abnormal_melanosome_morpholog1.38877034
29MP0001486_abnormal_startle_reflex1.38727741
30MP0000538_abnormal_urinary_bladder1.37032647
31MP0005451_abnormal_body_composition1.34230482
32MP0000689_abnormal_spleen_morphology1.33650498
33MP0002452_abnormal_antigen_presenting1.30902798
34MP0002722_abnormal_immune_system1.29825782
35MP0002420_abnormal_adaptive_immunity1.28150487
36MP0005410_abnormal_fertilization1.27985518
37MP0008877_abnormal_DNA_methylation1.27416041
38MP0002006_tumorigenesis1.26507513
39MP0004134_abnormal_chest_morphology1.23674285
40MP0002160_abnormal_reproductive_system1.23271112
41MP0000716_abnormal_immune_system1.20879892
42MP0001905_abnormal_dopamine_level1.20364622
43MP0000372_irregular_coat_pigmentation1.18183404
44MP0003693_abnormal_embryo_hatching1.18091832
45MP0003866_abnormal_defecation1.17983258
46MP0005423_abnormal_somatic_nervous1.16027994
47MP0002398_abnormal_bone_marrow1.15844302
48MP0006054_spinal_hemorrhage1.15119007
49MP0010094_abnormal_chromosome_stability1.13376305
50MP0002396_abnormal_hematopoietic_system1.12936270
51MP0005389_reproductive_system_phenotype1.12110533
52MP0002638_abnormal_pupillary_reflex1.10133955
53MP0001119_abnormal_female_reproductive1.08150536
54MP0001764_abnormal_homeostasis1.07873957
55MP0001873_stomach_inflammation1.05289367
56MP0000749_muscle_degeneration1.05254989
57MP0004742_abnormal_vestibular_system1.03545474
58MP0005025_abnormal_response_to1.03199794
59MP0008007_abnormal_cellular_replicative0.98340461
60MP0000383_abnormal_hair_follicle0.97303981
61MP0003646_muscle_fatigue0.95230467
62MP0001485_abnormal_pinna_reflex0.94616025
63MP0005000_abnormal_immune_tolerance0.92085949
64MP0000685_abnormal_immune_system0.91737743
65MP0005379_endocrine/exocrine_gland_phen0.90337133
66MP0002736_abnormal_nociception_after0.90327909
67MP0002429_abnormal_blood_cell0.89752570
68MP0001790_abnormal_immune_system0.87059551
69MP0005387_immune_system_phenotype0.87059551
70MP0004142_abnormal_muscle_tone0.86252098
71MP0003567_abnormal_fetal_cardiomyocyte0.85699339
72MP0005195_abnormal_posterior_eye0.84497575
73MP0002148_abnormal_hypersensitivity_rea0.83902797
74MP0009765_abnormal_xenobiotic_induced0.83441152
75MP0005645_abnormal_hypothalamus_physiol0.82979613
76MP0000465_gastrointestinal_hemorrhage0.81329222
77MP0000516_abnormal_urinary_system0.80665322
78MP0005367_renal/urinary_system_phenotyp0.80665322
79MP0002098_abnormal_vibrissa_morphology0.80517839
80MP0009745_abnormal_behavioral_response0.80358573
81MP0009046_muscle_twitch0.80011291
82MP0002272_abnormal_nervous_system0.78442055
83MP0002752_abnormal_somatic_nervous0.77473609
84MP0002210_abnormal_sex_determination0.75909359
85MP0003698_abnormal_male_reproductive0.75631312
86MP0001929_abnormal_gametogenesis0.74193578
87MP0001919_abnormal_reproductive_system0.74159320
88MP0003077_abnormal_cell_cycle0.73937130
89MP0002019_abnormal_tumor_incidence0.73172321
90MP0002090_abnormal_vision0.73002158
91MP0004233_abnormal_muscle_weight0.71446033
92MP0001968_abnormal_touch/_nociception0.70661197
93MP0000013_abnormal_adipose_tissue0.70558538
94MP0003718_maternal_effect0.67933991
95MP0002163_abnormal_gland_morphology0.67313823
96MP0001756_abnormal_urination0.66265351
97MP0001963_abnormal_hearing_physiology0.65921889
98MP0005167_abnormal_blood-brain_barrier0.65711862
99MP0003221_abnormal_cardiomyocyte_apopto0.64256698
100MP0003137_abnormal_impulse_conducting0.62748022

Predicted human phenotypes

RankGene SetZ-score
1Hypoproteinemia (HP:0003075)3.81523072
2Chin dimple (HP:0010751)3.76233184
3Abnormality of T cell number (HP:0011839)3.34694277
4T lymphocytopenia (HP:0005403)3.32482975
5Hypoplasia of the thymus (HP:0000778)3.28925707
6Abnormality of the prostate (HP:0008775)3.27721218
7Thyroiditis (HP:0100646)3.19617556
8Absent rod-and cone-mediated responses on ERG (HP:0007688)3.18232519
9Cerebral palsy (HP:0100021)3.09565837
10Hemoptysis (HP:0002105)3.09384393
11Obstructive lung disease (HP:0006536)3.07822976
12Chronic obstructive pulmonary disease (HP:0006510)3.07822976
13Eosinophilia (HP:0001880)3.05627877
14Neonatal respiratory distress (HP:0002643)3.00552682
15Abnormality of methionine metabolism (HP:0010901)2.99012150
16Abnormality of eosinophils (HP:0001879)2.90763787
17Constricted visual fields (HP:0001133)2.84418742
18Adactyly (HP:0009776)2.77216560
19Abnormality of aspartate family amino acid metabolism (HP:0010899)2.76417714
20Severe combined immunodeficiency (HP:0004430)2.74165024
21IgG deficiency (HP:0004315)2.73096613
22Dynein arm defect of respiratory motile cilia (HP:0012255)2.65958141
23Absent/shortened dynein arms (HP:0200106)2.65958141
24Ureteral stenosis (HP:0000071)2.56573968
25Aplastic anemia (HP:0001915)2.54101630
26Recurrent cutaneous fungal infections (HP:0011370)2.39706396
27Chronic mucocutaneous candidiasis (HP:0002728)2.39706396
28Granulocytopenia (HP:0001913)2.39211174
29Ureteral obstruction (HP:0006000)2.38422630
30Stomatitis (HP:0010280)2.36555897
31Pigmentary retinal degeneration (HP:0001146)2.33075515
32Renal cortical cysts (HP:0000803)2.31817187
33Hypoalbuminemia (HP:0003073)2.30648398
34Abnormal albumin level (HP:0012116)2.30648398
35Abnormality of the pleura (HP:0002103)2.29951103
36Abnormal rod and cone electroretinograms (HP:0008323)2.28922247
37Autoimmune hemolytic anemia (HP:0001890)2.27987369
38Pancreatic islet-cell hyperplasia (HP:0004510)2.27608700
39Hematochezia (HP:0002573)2.26575862
40Abolished electroretinogram (ERG) (HP:0000550)2.26433237
41Severe muscular hypotonia (HP:0006829)2.23506769
42Pancreatic cysts (HP:0001737)2.21120879
43Aplasia/Hypoplasia of the tibia (HP:0005772)2.20184612
44Hemiplegia (HP:0002301)2.19261068
45Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.15061042
46Abnormal protein N-linked glycosylation (HP:0012347)2.15061042
47Abnormal protein glycosylation (HP:0012346)2.15061042
48Abnormal glycosylation (HP:0012345)2.15061042
49Abnormality of T cells (HP:0002843)2.12756059
50Optic disc pallor (HP:0000543)2.10068204
51Increased CSF lactate (HP:0002490)2.05243616
52IgM deficiency (HP:0002850)2.04230141
53Type I transferrin isoform profile (HP:0003642)2.01132142
54Vasculitis (HP:0002633)2.00634967
55Gastrointestinal infarctions (HP:0005244)2.00610559
56Progressive inability to walk (HP:0002505)1.99404574
57Increased IgM level (HP:0003496)1.98884281
58Lymphoma (HP:0002665)1.97248894
59Chronic diarrhea (HP:0002028)1.96238039
60Chorioretinal coloboma (HP:0000567)1.94811909
61Abnormality of small intestinal villus morphology (HP:0011472)1.92819445
62Villous atrophy (HP:0011473)1.92819445
63Recurrent sinusitis (HP:0011108)1.91379748
64Leukocytosis (HP:0001974)1.90628498
65Colon cancer (HP:0003003)1.90088470
66Attenuation of retinal blood vessels (HP:0007843)1.89901953
67Short tibia (HP:0005736)1.89224287
68Abnormality of male internal genitalia (HP:0000022)1.89007673
69Abnormality of the renal cortex (HP:0011035)1.85974706
70Combined immunodeficiency (HP:0005387)1.85967603
71Dyschromatopsia (HP:0007641)1.85966902
72Acute necrotizing encephalopathy (HP:0006965)1.85656870
73Abnormality of the astrocytes (HP:0100707)1.84337049
74Astrocytoma (HP:0009592)1.84337049
75Congenital stationary night blindness (HP:0007642)1.82787787
76Aplasia/Hypoplasia of the patella (HP:0006498)1.82696284
773-Methylglutaconic aciduria (HP:0003535)1.82450216
78Abnormality of the pericardium (HP:0001697)1.80703736
79Hypoplastic pelvis (HP:0008839)1.78280170
80Meningitis (HP:0001287)1.78226150
81Progressive macrocephaly (HP:0004481)1.76511955
82Cerebral edema (HP:0002181)1.76489999
83Acrocyanosis (HP:0001063)1.76456845
84Abnormal respiratory epithelium morphology (HP:0012253)1.76298672
85Abnormal respiratory motile cilium morphology (HP:0005938)1.76298672
86Methylmalonic acidemia (HP:0002912)1.74849510
87Abnormal delayed hypersensitivity skin test (HP:0002963)1.74772716
88Reduced antithrombin III activity (HP:0001976)1.73737992
89Erythroderma (HP:0001019)1.72712436
90Abnormality of B cell number (HP:0010975)1.70611807
91Mitochondrial inheritance (HP:0001427)1.68793323
92Pustule (HP:0200039)1.67671128
93Severe visual impairment (HP:0001141)1.66934955
94Decreased electroretinogram (ERG) amplitude (HP:0000654)1.66543814
95Glomerulopathy (HP:0100820)1.65843709
96Methylmalonic aciduria (HP:0012120)1.65075472
97Neoplasm of the adrenal cortex (HP:0100641)1.64993327
98Abnormality of the vitamin B12 metabolism (HP:0004341)1.64843777
99Exercise-induced muscle cramps (HP:0003710)1.64123698
100Abnormality of oral frenula (HP:0000190)1.63590925

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK25.17394822
2FRK4.35381274
3TXK4.26884632
4TLK12.99651535
5MAP4K22.82870683
6ZAK2.66274431
7KDR2.54055077
8BCKDK2.49074411
9VRK12.12060683
10NLK2.01398278
11WNK31.94746354
12MUSK1.88156822
13BCR1.87062934
14ADRBK21.79931742
15ITK1.74163326
16AKT31.70107880
17EPHA31.67941558
18BMPR1B1.67622063
19CSNK1A1L1.61789655
20BTK1.58246794
21SRPK11.55182697
22MAP3K121.55073934
23NEK61.48023371
24RPS6KA51.44878828
25CSNK1G31.39705019
26GRK11.32604398
27PASK1.30684957
28RPS6KA41.29252577
29MAP4K11.27084984
30TEC1.23214019
31PLK21.21949294
32STK161.19641372
33BUB11.14409490
34MKNK21.13661339
35MAPK131.08855259
36MAPK71.08597293
37PIK3CA1.05586037
38TNIK1.04287648
39MAP2K71.02501757
40CSNK1G11.02218151
41MKNK11.01390341
42SYK0.95563854
43TAOK30.95496375
44CDK80.92690951
45CDK190.90922187
46LCK0.90430093
47BRD40.87151377
48CSNK1G20.83563545
49IKBKE0.83084987
50CSK0.80579066
51SCYL20.80385198
52PRKCQ0.76245342
53TNK20.75910207
54PAK30.74264975
55JAK30.73680452
56IKBKB0.70690042
57MST40.69850734
58FLT30.67288783
59FES0.62770980
60CDK120.61736012
61LYN0.55607327
62ATR0.55532302
63FGFR20.53561828
64PRKCE0.53077614
65PINK10.52445333
66ERBB20.51828339
67CDK30.51145381
68HCK0.50886259
69TESK20.49651662
70TRIM280.49645952
71MAPK150.48577268
72MATK0.46845326
73MAP3K110.46754557
74PIM10.43189353
75CLK10.41849688
76PKN10.41674727
77CSNK2A10.41100641
78MAP3K40.40769594
79NUAK10.39536818
80RIPK10.39113079
81EIF2AK30.37622209
82PDK10.36343633
83INSRR0.35355181
84FGFR10.35021701
85CAMK10.34968515
86ATM0.34706517
87PIM20.33989977
88CSNK1A10.32699734
89CSNK1D0.31223167
90OXSR10.30574344
91PLK30.30334961
92NEK10.29562841
93SGK20.29302410
94NEK90.28386209
95DYRK1A0.27677368
96CDK90.27644350
97MAP3K50.27626053
98FER0.27362938
99MAPK90.26862304
100ACVR1B0.26631034

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.34873043
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.51018210
3Graft-versus-host disease_Homo sapiens_hsa053323.35322694
4Allograft rejection_Homo sapiens_hsa053303.14257058
5Primary immunodeficiency_Homo sapiens_hsa053403.13860015
6Asthma_Homo sapiens_hsa053102.98161714
7Autoimmune thyroid disease_Homo sapiens_hsa053202.95207376
8Protein export_Homo sapiens_hsa030602.72340465
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.52213248
10Antigen processing and presentation_Homo sapiens_hsa046122.49295881
11Type I diabetes mellitus_Homo sapiens_hsa049402.44860837
12Systemic lupus erythematosus_Homo sapiens_hsa053222.37017167
13Basal transcription factors_Homo sapiens_hsa030222.15546714
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.91776210
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.83137751
16Rheumatoid arthritis_Homo sapiens_hsa053231.78549504
17Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.72990907
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.66412808
19Propanoate metabolism_Homo sapiens_hsa006401.60805713
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.53436623
21One carbon pool by folate_Homo sapiens_hsa006701.50997988
22Viral myocarditis_Homo sapiens_hsa054161.49548401
23Selenocompound metabolism_Homo sapiens_hsa004501.47847829
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.42539712
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.25499090
26Homologous recombination_Homo sapiens_hsa034401.23034297
27Nitrogen metabolism_Homo sapiens_hsa009101.20571402
28RNA polymerase_Homo sapiens_hsa030201.19851966
29RNA degradation_Homo sapiens_hsa030181.18414174
30Peroxisome_Homo sapiens_hsa041461.17661348
31Oxidative phosphorylation_Homo sapiens_hsa001901.16776153
32Fanconi anemia pathway_Homo sapiens_hsa034601.13867834
33Alcoholism_Homo sapiens_hsa050341.11774938
34Primary bile acid biosynthesis_Homo sapiens_hsa001201.10736879
35Non-homologous end-joining_Homo sapiens_hsa034501.08695510
36Hematopoietic cell lineage_Homo sapiens_hsa046401.08565546
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.08011303
38Spliceosome_Homo sapiens_hsa030401.03686015
39Olfactory transduction_Homo sapiens_hsa047401.01668584
40Staphylococcus aureus infection_Homo sapiens_hsa051500.99648669
41Parkinsons disease_Homo sapiens_hsa050120.98127044
42Butanoate metabolism_Homo sapiens_hsa006500.94934755
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92736007
44Phototransduction_Homo sapiens_hsa047440.91319927
45T cell receptor signaling pathway_Homo sapiens_hsa046600.88297065
46Taste transduction_Homo sapiens_hsa047420.87058813
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.84266849
48Transcriptional misregulation in cancer_Homo sapiens_hsa052020.79795759
49Herpes simplex infection_Homo sapiens_hsa051680.79588951
50Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.77796378
51RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.76655773
52Steroid hormone biosynthesis_Homo sapiens_hsa001400.71252930
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71190567
54Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71127188
55Notch signaling pathway_Homo sapiens_hsa043300.68523972
56NF-kappa B signaling pathway_Homo sapiens_hsa040640.68428203
57Retinol metabolism_Homo sapiens_hsa008300.67124241
58Tryptophan metabolism_Homo sapiens_hsa003800.66939223
59Huntingtons disease_Homo sapiens_hsa050160.66505504
60Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66267657
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65449676
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65077040
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.61484912
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57554819
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57469225
66RNA transport_Homo sapiens_hsa030130.54384298
67Epstein-Barr virus infection_Homo sapiens_hsa051690.53823540
68Leishmaniasis_Homo sapiens_hsa051400.52641178
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51694002
70Fatty acid elongation_Homo sapiens_hsa000620.51268822
71Chemical carcinogenesis_Homo sapiens_hsa052040.50814207
72HTLV-I infection_Homo sapiens_hsa051660.50315008
73African trypanosomiasis_Homo sapiens_hsa051430.48517133
74Nucleotide excision repair_Homo sapiens_hsa034200.48256171
75Sulfur metabolism_Homo sapiens_hsa009200.47768365
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46984831
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45400479
78Base excision repair_Homo sapiens_hsa034100.45038302
79Cell cycle_Homo sapiens_hsa041100.44930360
80Regulation of autophagy_Homo sapiens_hsa041400.44089550
81mRNA surveillance pathway_Homo sapiens_hsa030150.42740925
82N-Glycan biosynthesis_Homo sapiens_hsa005100.40944598
83Alzheimers disease_Homo sapiens_hsa050100.39954682
84Mismatch repair_Homo sapiens_hsa034300.39289217
85Circadian rhythm_Homo sapiens_hsa047100.38870349
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37779003
87Tuberculosis_Homo sapiens_hsa051520.37740284
88Viral carcinogenesis_Homo sapiens_hsa052030.37661972
89Malaria_Homo sapiens_hsa051440.35103725
90Purine metabolism_Homo sapiens_hsa002300.34570334
91Measles_Homo sapiens_hsa051620.34265580
92alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30588498
93Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.30281242
94beta-Alanine metabolism_Homo sapiens_hsa004100.30005015
95Metabolic pathways_Homo sapiens_hsa011000.28888480
96Carbon metabolism_Homo sapiens_hsa012000.27651538
97Pyrimidine metabolism_Homo sapiens_hsa002400.27480092
98Lysine degradation_Homo sapiens_hsa003100.27334615
99Legionellosis_Homo sapiens_hsa051340.26109530
100Oocyte meiosis_Homo sapiens_hsa041140.25927545

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