PRMT5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme that belongs to the methyltransferase family. The encoded protein catalyzes the transfer of methyl groups to the amino acid arginine, in target proteins that include histones, transcriptional elongation factors and the tumor suppressor p53. This gene plays a role in several cellular processes, including transcriptional regulation, and the assembly of small nuclear ribonucleoproteins. A pseudogene of this gene has been defined on chromosome 4. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of SSU-rRNA (GO:0030490)5.00640410
2nucleobase biosynthetic process (GO:0046112)4.65001870
3DNA replication initiation (GO:0006270)4.64569584
4DNA strand elongation involved in DNA replication (GO:0006271)4.60059688
5formation of translation preinitiation complex (GO:0001731)4.42321936
6DNA unwinding involved in DNA replication (GO:0006268)4.42030361
7DNA strand elongation (GO:0022616)4.38458917
8purine nucleobase biosynthetic process (GO:0009113)4.35035163
9mitotic chromosome condensation (GO:0007076)4.31240247
10ribosomal large subunit biogenesis (GO:0042273)4.30759177
11ribosomal small subunit assembly (GO:0000028)4.24245031
12telomere maintenance via semi-conservative replication (GO:0032201)4.23809474
13DNA replication checkpoint (GO:0000076)4.18129791
14regulation of translational fidelity (GO:0006450)4.17523564
15mitotic metaphase plate congression (GO:0007080)4.12698086
16IMP biosynthetic process (GO:0006188)4.12347345
17ribosome biogenesis (GO:0042254)4.08423022
18viral transcription (GO:0019083)4.04628422
19ribosome assembly (GO:0042255)4.00819872
20ribonucleoprotein complex biogenesis (GO:0022613)3.99059682
21translational termination (GO:0006415)3.98085085
22sister chromatid segregation (GO:0000819)3.95154083
23mitotic nuclear envelope disassembly (GO:0007077)3.93955505
24establishment of viral latency (GO:0019043)3.89455196
25* spliceosomal snRNP assembly (GO:0000387)3.89218009
26protein localization to kinetochore (GO:0034501)3.89025715
27translational initiation (GO:0006413)3.80585270
28telomere maintenance via recombination (GO:0000722)3.76838162
29DNA replication-dependent nucleosome organization (GO:0034723)3.68358706
30DNA replication-dependent nucleosome assembly (GO:0006335)3.68358706
31folic acid-containing compound biosynthetic process (GO:0009396)3.67455688
32proline biosynthetic process (GO:0006561)3.67283246
33translational elongation (GO:0006414)3.67199848
34pore complex assembly (GO:0046931)3.64738086
35rRNA processing (GO:0006364)3.64084456
36membrane disassembly (GO:0030397)3.63457651
37nuclear envelope disassembly (GO:0051081)3.63457651
38ribosomal small subunit biogenesis (GO:0042274)3.63188009
39mitotic recombination (GO:0006312)3.59565419
40nuclear pore organization (GO:0006999)3.56599724
41tRNA aminoacylation for protein translation (GO:0006418)3.55894968
42L-serine metabolic process (GO:0006563)3.55657145
43telomere maintenance via telomere lengthening (GO:0010833)3.53200757
44rRNA metabolic process (GO:0016072)3.52515655
45IMP metabolic process (GO:0046040)3.51937688
46DNA deamination (GO:0045006)3.50905843
47nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.50223825
48metaphase plate congression (GO:0051310)3.47497768
49tRNA aminoacylation (GO:0043039)3.44229604
50amino acid activation (GO:0043038)3.44229604
51viral mRNA export from host cell nucleus (GO:0046784)3.40411292
52regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.39053207
53pseudouridine synthesis (GO:0001522)3.38620367
54DNA topological change (GO:0006265)3.36040146
55chromatin remodeling at centromere (GO:0031055)3.36008810
56nucleotide-excision repair, DNA gap filling (GO:0006297)3.35622226
57CENP-A containing nucleosome assembly (GO:0034080)3.35345456
58spliceosomal complex assembly (GO:0000245)3.34375844
59proteasome assembly (GO:0043248)3.29476208
60negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.28572262
61protein complex localization (GO:0031503)3.27685534
62spliceosomal tri-snRNP complex assembly (GO:0000244)3.27637158
63protein localization to chromosome, centromeric region (GO:0071459)3.27604330
64mitotic sister chromatid segregation (GO:0000070)3.24487439
65SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.24378408
66transcription-coupled nucleotide-excision repair (GO:0006283)3.23389543
67cellular protein complex disassembly (GO:0043624)3.22867137
68rRNA modification (GO:0000154)3.22457663
69anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.22158522
70nuclear pore complex assembly (GO:0051292)3.20719311
71COPI coating of Golgi vesicle (GO:0048205)3.20277325
72Golgi transport vesicle coating (GO:0048200)3.20277325
73heterochromatin organization (GO:0070828)3.20103789
74nucleobase-containing small molecule interconversion (GO:0015949)3.19544910
75regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.19039851
76DNA ligation (GO:0006266)3.18418022
77DNA replication-independent nucleosome assembly (GO:0006336)3.17522403
78DNA replication-independent nucleosome organization (GO:0034724)3.17522403
79RNA splicing, via transesterification reactions (GO:0000375)3.17205859
80RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.16360092
81mRNA splicing, via spliceosome (GO:0000398)3.16360092
82kinetochore organization (GO:0051383)3.15725680
83regulation of spindle organization (GO:0090224)3.15710010
84cotranslational protein targeting to membrane (GO:0006613)3.15158945
85negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.14149829
86protein targeting to ER (GO:0045047)3.13851844
87maturation of 5.8S rRNA (GO:0000460)3.13813020
88regulation of mitochondrial translation (GO:0070129)3.10663119
89termination of RNA polymerase III transcription (GO:0006386)3.10588250
90transcription elongation from RNA polymerase III promoter (GO:0006385)3.10588250
91regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.10479857
92negative regulation of mRNA processing (GO:0050686)3.09836333
93viral life cycle (GO:0019058)3.08545238
94positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.07930429
95mitotic sister chromatid cohesion (GO:0007064)3.07807496
96somatic hypermutation of immunoglobulin genes (GO:0016446)3.06872030
97somatic diversification of immune receptors via somatic mutation (GO:0002566)3.06872030
98negative regulation of chromosome segregation (GO:0051985)3.06390835
99establishment of chromosome localization (GO:0051303)3.05928767
100negative regulation of RNA splicing (GO:0033119)3.05335441
101protein complex disassembly (GO:0043241)3.04682899
102negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.03580378
103negative regulation of sister chromatid segregation (GO:0033046)3.03580378
104negative regulation of mitotic sister chromatid separation (GO:2000816)3.03580378
105negative regulation of mitotic sister chromatid segregation (GO:0033048)3.03580378
106cellular component biogenesis (GO:0044085)3.02954539
107negative regulation of ligase activity (GO:0051352)3.02645714
108negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.02645714
109kinetochore assembly (GO:0051382)3.00693298
110mitotic spindle assembly checkpoint (GO:0007094)3.00133369
111regulation of mitotic spindle organization (GO:0060236)3.00004111
112non-recombinational repair (GO:0000726)2.99397118
113double-strand break repair via nonhomologous end joining (GO:0006303)2.99397118
114establishment of integrated proviral latency (GO:0075713)2.99189254
115spindle checkpoint (GO:0031577)2.99130070
116spindle assembly checkpoint (GO:0071173)2.99105420
117translation (GO:0006412)2.97457028
118mitotic spindle checkpoint (GO:0071174)2.97135017
119establishment of protein localization to endoplasmic reticulum (GO:0072599)2.96670680
120DNA duplex unwinding (GO:0032508)2.96149139
121regulation of chromosome segregation (GO:0051983)2.95064069
122regulation of double-strand break repair via homologous recombination (GO:0010569)2.94902675
123DNA geometric change (GO:0032392)2.94579104
124negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.93646780
1257-methylguanosine mRNA capping (GO:0006370)2.93376059
126protein localization to endoplasmic reticulum (GO:0070972)2.93034426
127cullin deneddylation (GO:0010388)2.92198563
128base-excision repair (GO:0006284)2.91369606
129cellular protein complex localization (GO:0034629)2.84065887
130negative regulation of mRNA metabolic process (GO:1903312)2.82754348
131chromosome condensation (GO:0030261)2.82350025
132regulation of translational termination (GO:0006449)2.82323958
133nuclear envelope organization (GO:0006998)2.81078659
134chromosome segregation (GO:0007059)2.79143756
135DNA conformation change (GO:0071103)2.78005987
136regulation of translational elongation (GO:0006448)2.77206250
137regulation of sister chromatid cohesion (GO:0007063)2.75837638

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.31856338
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.69264966
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.82880433
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.70021816
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.56155172
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.42894232
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.18627729
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.12046507
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.07340504
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse3.06537169
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.05530785
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.05324243
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.95760162
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.78257101
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.77132835
16* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.67844888
17* XRN2_22483619_ChIP-Seq_HELA_Human2.57126078
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.44630868
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.38906777
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.37089868
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.32358542
22* VDR_23849224_ChIP-Seq_CD4+_Human2.17915649
23THAP11_20581084_ChIP-Seq_MESCs_Mouse2.12460411
24MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.04814265
25* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.04733167
26* TTF2_22483619_ChIP-Seq_HELA_Human2.00137782
27DCP1A_22483619_ChIP-Seq_HELA_Human2.00001795
28POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.99512389
29FOXP3_21729870_ChIP-Seq_TREG_Human1.98997983
30MYCN_18555785_ChIP-Seq_MESCs_Mouse1.95525970
31NANOG_18555785_ChIP-Seq_MESCs_Mouse1.94889829
32GABP_19822575_ChIP-Seq_HepG2_Human1.92074667
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.90130967
34E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.89568138
35E2F1_21310950_ChIP-Seq_MCF-7_Human1.88755443
36SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.88451898
37AR_21909140_ChIP-Seq_LNCAP_Human1.87470602
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.86426315
39KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.84070352
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.80847273
41* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.77470284
42* CIITA_25753668_ChIP-Seq_RAJI_Human1.75798053
43ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.67292989
44ZNF263_19887448_ChIP-Seq_K562_Human1.65961380
45* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65245464
46MYC_22102868_ChIP-Seq_BL_Human1.64480111
47POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.60093849
48POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.55821904
49ZFX_18555785_ChIP-Seq_MESCs_Mouse1.55402864
50CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.52928956
51ELK1_19687146_ChIP-ChIP_HELA_Human1.52410115
52HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.49961454
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.47273271
54TP63_19390658_ChIP-ChIP_HaCaT_Human1.46672153
55PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.45452650
56SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.45368248
57KDM5A_27292631_Chip-Seq_BREAST_Human1.45324860
58TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.41911153
59SOX2_18555785_ChIP-Seq_MESCs_Mouse1.41632385
60CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.40772092
61FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.38735332
62KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.38393623
63MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.36544803
64EGR1_19374776_ChIP-ChIP_THP-1_Human1.32547646
65RBPJ_22232070_ChIP-Seq_NCS_Mouse1.32346726
66SRF_21415370_ChIP-Seq_HL-1_Mouse1.23512547
67* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.23432330
68STAT3_1855785_ChIP-Seq_MESCs_Mouse1.22384202
69KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21640484
70ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.21363103
71TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.19440931
72ESR1_15608294_ChIP-ChIP_MCF-7_Human1.18354953
73* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.16816676
74KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.14492495
75* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.11745177
76CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.11022706
77KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.09984313
78KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.09984313
79KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.09984313
80* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.09867451
81TCF3_18692474_ChIP-Seq_MEFs_Mouse1.09733288
82* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09339997
83SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08969773
84E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08031025
85SOX17_20123909_ChIP-Seq_XEN_Mouse1.07131545
86DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.06951199
87FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05740722
88NANOG_21062744_ChIP-ChIP_HESCs_Human1.05418362
89NOTCH1_21737748_ChIP-Seq_TLL_Human1.05160503
90ERG_20887958_ChIP-Seq_HPC-7_Mouse1.03226908
91TFEB_21752829_ChIP-Seq_HELA_Human1.02905492
92PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.02687199
93MYC_18940864_ChIP-ChIP_HL60_Human1.02331417
94ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02239297
95SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.01760029
96CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00596699
97NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.00357626
98BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00093770
99TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97992950
100* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95828466
101TBX5_21415370_ChIP-Seq_HL-1_Mouse0.95810835
102PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.95556670
103NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.95527933
104TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.94971760
105OCT4_18692474_ChIP-Seq_MEFs_Mouse0.94127933
106CHD1_26751641_Chip-Seq_LNCaP_Human0.93940149
107CLOCK_20551151_ChIP-Seq_293T_Human0.93888917
108SOX2_18692474_ChIP-Seq_MEFs_Mouse0.92900891
109ELK1_22589737_ChIP-Seq_MCF10A_Human0.92894274
110ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.92854194
111CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.92548401
112TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92350398
113CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.91830310
114SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.91329907
115NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.88602490
116ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.84628140
117TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.83465336
118TCF3_18692474_ChIP-Seq_MESCs_Mouse0.80719312

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.30266752
2MP0003111_abnormal_nucleus_morphology4.54495196
3MP0004957_abnormal_blastocyst_morpholog4.44558491
4MP0010094_abnormal_chromosome_stability4.40411691
5MP0003077_abnormal_cell_cycle3.94307032
6MP0008057_abnormal_DNA_replication3.67523445
7MP0008058_abnormal_DNA_repair3.41400041
8MP0003123_paternal_imprinting2.79995148
9MP0008007_abnormal_cellular_replicative2.77906023
10* MP0008932_abnormal_embryonic_tissue2.71754710
11MP0001730_embryonic_growth_arrest2.45651067
12MP0000350_abnormal_cell_proliferation2.32354853
13MP0010030_abnormal_orbit_morphology2.21697879
14MP0009697_abnormal_copulation2.18132504
15MP0003786_premature_aging2.16521909
16MP0008877_abnormal_DNA_methylation2.13516987
17MP0005380_embryogenesis_phenotype1.90412733
18MP0001672_abnormal_embryogenesis/_devel1.90412733
19MP0001697_abnormal_embryo_size1.86635605
20MP0002085_abnormal_embryonic_tissue1.80667164
21MP0003315_abnormal_perineum_morphology1.76860453
22MP0006292_abnormal_olfactory_placode1.76607460
23MP0002396_abnormal_hematopoietic_system1.74398414
24MP0002653_abnormal_ependyma_morphology1.74201638
25MP0003984_embryonic_growth_retardation1.69890751
26* MP0002080_prenatal_lethality1.68668537
27MP0002088_abnormal_embryonic_growth/wei1.66026925
28MP0002084_abnormal_developmental_patter1.65950973
29MP0003718_maternal_effect1.61262967
30MP0010352_gastrointestinal_tract_polyps1.59903194
31MP0006035_abnormal_mitochondrial_morpho1.56352950
32MP0003119_abnormal_digestive_system1.55959640
33MP0005451_abnormal_body_composition1.55461490
34MP0002877_abnormal_melanocyte_morpholog1.50297517
35MP0003890_abnormal_embryonic-extraembry1.49781876
36MP0003121_genomic_imprinting1.49415086
37MP0001293_anophthalmia1.47410566
38MP0000490_abnormal_crypts_of1.47223986
39MP0003567_abnormal_fetal_cardiomyocyte1.46874770
40MP0004197_abnormal_fetal_growth/weight/1.46012128
41MP0009053_abnormal_anal_canal1.40788716
42MP0010307_abnormal_tumor_latency1.37422235
43MP0000313_abnormal_cell_death1.36017011
44MP0002160_abnormal_reproductive_system1.35970872
45MP0000537_abnormal_urethra_morphology1.35422351
46MP0003806_abnormal_nucleotide_metabolis1.35270469
47MP0002086_abnormal_extraembryonic_tissu1.32032127
48MP0000566_synostosis1.29046922
49MP0004133_heterotaxia1.27392103
50MP0002210_abnormal_sex_determination1.27102277
51MP0008789_abnormal_olfactory_epithelium1.23663894
52MP0001661_extended_life_span1.21448874
53MP0005501_abnormal_skin_physiology1.21174390
54MP0002019_abnormal_tumor_incidence1.18511476
55MP0009333_abnormal_splenocyte_physiolog1.17406755
56MP0002697_abnormal_eye_size1.13924270
57MP0009379_abnormal_foot_pigmentation1.13685715
58MP0002751_abnormal_autonomic_nervous1.13170871
59MP0000428_abnormal_craniofacial_morphol1.12833261
60MP0001346_abnormal_lacrimal_gland1.11777275
61MP0004808_abnormal_hematopoietic_stem1.11026843
62MP0001529_abnormal_vocalization1.10945873
63MP0000049_abnormal_middle_ear1.09242297
64MP0001145_abnormal_male_reproductive1.09230912
65MP0003705_abnormal_hypodermis_morpholog1.08510363
66MP0005076_abnormal_cell_differentiation1.06076679
67MP0002111_abnormal_tail_morphology1.05259510
68MP0003186_abnormal_redox_activity1.05032498
69MP0010234_abnormal_vibrissa_follicle1.04008969
70MP0006036_abnormal_mitochondrial_physio1.03932696
71MP0003136_yellow_coat_color1.03047505
72MP0005623_abnormal_meninges_morphology1.02995828
73MP0000678_abnormal_parathyroid_gland1.02773404
74MP0009672_abnormal_birth_weight1.02274123
75MP0003937_abnormal_limbs/digits/tail_de1.01201231
76MP0001849_ear_inflammation1.00592664
77MP0003941_abnormal_skin_development0.99314811
78MP0000762_abnormal_tongue_morphology0.97868139
79MP0005394_taste/olfaction_phenotype0.97804765
80MP0005499_abnormal_olfactory_system0.97804765
81MP0002796_impaired_skin_barrier0.95503042
82MP0000358_abnormal_cell_content/0.95336319
83MP0002233_abnormal_nose_morphology0.95259235
84MP0003566_abnormal_cell_adhesion0.95222475
85MP0000703_abnormal_thymus_morphology0.92192060
86MP0005389_reproductive_system_phenotype0.92121938
87MP0003938_abnormal_ear_development0.91799867
88MP0004185_abnormal_adipocyte_glucose0.91645916
89MP0001286_abnormal_eye_development0.90661572
90MP0004272_abnormal_basement_membrane0.90643912
91MP0000579_abnormal_nail_morphology0.88979688
92MP0002234_abnormal_pharynx_morphology0.88705184
93MP0000653_abnormal_sex_gland0.87437110
94MP0003861_abnormal_nervous_system0.87314116
95MP0002938_white_spotting0.84978733
96MP0003763_abnormal_thymus_physiology0.83936324
97MP0003221_abnormal_cardiomyocyte_apopto0.83458998
98MP0001929_abnormal_gametogenesis0.83063343
99MP0002102_abnormal_ear_morphology0.82173060
100MP0003942_abnormal_urinary_system0.81599877
101MP0005257_abnormal_intraocular_pressure0.81531995
102MP0001919_abnormal_reproductive_system0.79818059
103MP0001727_abnormal_embryo_implantation0.78441985
104MP0005621_abnormal_cell_physiology0.77279078
105MP0008260_abnormal_autophagy0.76774288
106MP0002249_abnormal_larynx_morphology0.76771499
107MP0001545_abnormal_hematopoietic_system0.75515757
108MP0005397_hematopoietic_system_phenotyp0.75515757
109MP0002269_muscular_atrophy0.74648138
110MP0009703_decreased_birth_body0.74449942
111MP0005330_cardiomyopathy0.73683881
112MP0002092_abnormal_eye_morphology0.71855220
113MP0005384_cellular_phenotype0.71665526
114MP0002114_abnormal_axial_skeleton0.71502600
115MP0000751_myopathy0.70037670
116MP0008995_early_reproductive_senescence0.69334610
117MP0001119_abnormal_female_reproductive0.69271037
118MP0003935_abnormal_craniofacial_develop0.68714694
119MP0000432_abnormal_head_morphology0.68496535
120MP0001188_hyperpigmentation0.66882917
121MP0003755_abnormal_palate_morphology0.66529059
122MP0002932_abnormal_joint_morphology0.64822238
123MP0002132_abnormal_respiratory_system0.64310401
124MP0004233_abnormal_muscle_weight0.62954059
125MP0002722_abnormal_immune_system0.62814457
126MP0000750_abnormal_muscle_regeneration0.61189187
127MP0002127_abnormal_cardiovascular_syste0.60931423
128MP0003115_abnormal_respiratory_system0.60861330
129MP0003385_abnormal_body_wall0.60592426
130MP0003878_abnormal_ear_physiology0.59409865
131MP0005377_hearing/vestibular/ear_phenot0.59409865
132MP0001915_intracranial_hemorrhage0.59089072
133MP0000015_abnormal_ear_pigmentation0.59026708

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.48455081
2Reticulocytopenia (HP:0001896)4.20261165
3Breast hypoplasia (HP:0003187)4.02354662
4Patellar aplasia (HP:0006443)3.51392305
5Abnormality of cells of the erythroid lineage (HP:0012130)3.44556585
6Ependymoma (HP:0002888)3.44298009
7Aplasia/Hypoplasia of the patella (HP:0006498)3.43724494
8Colon cancer (HP:0003003)3.42222151
9Cholecystitis (HP:0001082)3.41888487
10Abnormal gallbladder physiology (HP:0012438)3.41888487
11Carpal bone hypoplasia (HP:0001498)3.41208904
12Oral leukoplakia (HP:0002745)3.37281254
13Selective tooth agenesis (HP:0001592)3.32534593
14Impulsivity (HP:0100710)3.32367945
15Degeneration of anterior horn cells (HP:0002398)3.25561201
16Abnormality of the anterior horn cell (HP:0006802)3.25561201
17Cerebral hypomyelination (HP:0006808)3.23294589
18Abnormal number of erythroid precursors (HP:0012131)3.19301229
19Medulloblastoma (HP:0002885)3.14810249
20Rough bone trabeculation (HP:0100670)3.08752530
21Meckel diverticulum (HP:0002245)2.95094753
22Absent thumb (HP:0009777)2.90244998
23Absent radius (HP:0003974)2.84191854
24Macrocytic anemia (HP:0001972)2.81401712
25Abnormality of the ileum (HP:0001549)2.80330916
26Abnormality of the labia minora (HP:0012880)2.78017862
27Abnormality of the preputium (HP:0100587)2.76934413
28Cortical dysplasia (HP:0002539)2.76644287
29Supernumerary spleens (HP:0009799)2.73815504
30Chromsome breakage (HP:0040012)2.73291683
31Chromosomal breakage induced by crosslinking agents (HP:0003221)2.69440986
32Rhabdomyosarcoma (HP:0002859)2.68200321
33Absent forearm bone (HP:0003953)2.66765738
34Aplasia involving forearm bones (HP:0009822)2.66765738
35Aplasia/Hypoplasia of the uvula (HP:0010293)2.63561105
36Abnormal number of incisors (HP:0011064)2.63203687
37Horseshoe kidney (HP:0000085)2.59171602
38Aplastic anemia (HP:0001915)2.57378856
39Abnormal lung lobation (HP:0002101)2.57316863
40Agnosia (HP:0010524)2.56917204
41Progressive external ophthalmoplegia (HP:0000590)2.51086909
42Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.48402582
43Neoplasm of the pancreas (HP:0002894)2.46338002
44Abnormality of chromosome stability (HP:0003220)2.45182595
45Premature graying of hair (HP:0002216)2.42817555
46Reduced antithrombin III activity (HP:0001976)2.40388036
47Pallor (HP:0000980)2.40058848
48Trismus (HP:0000211)2.33574047
49Triphalangeal thumb (HP:0001199)2.31997647
50Duodenal stenosis (HP:0100867)2.31080284
51Small intestinal stenosis (HP:0012848)2.31080284
52Aplasia/Hypoplasia of the sacrum (HP:0008517)2.29328547
53Atresia of the external auditory canal (HP:0000413)2.28775209
54Nephroblastoma (Wilms tumor) (HP:0002667)2.27353574
55Tracheoesophageal fistula (HP:0002575)2.26168948
5611 pairs of ribs (HP:0000878)2.25894704
57Spastic diplegia (HP:0001264)2.17048493
58Myelodysplasia (HP:0002863)2.15237342
59Cleft eyelid (HP:0000625)2.14526173
60Bone marrow hypocellularity (HP:0005528)2.14313305
61Hypoplasia of the radius (HP:0002984)2.13027169
62Abnormality of the astrocytes (HP:0100707)2.12570585
63Astrocytoma (HP:0009592)2.12570585
64Insomnia (HP:0100785)2.11772100
65Progressive muscle weakness (HP:0003323)2.11614429
66Cellular immunodeficiency (HP:0005374)2.11457513
67Ragged-red muscle fibers (HP:0003200)2.10948544
68Abnormality of abdominal situs (HP:0011620)2.09938401
69Abdominal situs inversus (HP:0003363)2.09938401
70Abnormality of cochlea (HP:0000375)2.09433287
71Microglossia (HP:0000171)2.08698851
72Microretrognathia (HP:0000308)2.07517214
73Embryonal renal neoplasm (HP:0011794)2.07275585
74Glioma (HP:0009733)2.07162802
75Premature ovarian failure (HP:0008209)2.06887185
76Atrophy/Degeneration involving motor neurons (HP:0007373)2.06802445
77Abnormality of the umbilical cord (HP:0010881)2.06231711
78Basal cell carcinoma (HP:0002671)2.05090311
79Aplasia/Hypoplasia of the sternum (HP:0006714)2.04865737
80Abnormality of glycolysis (HP:0004366)2.04395428
81Increased serum pyruvate (HP:0003542)2.04395428
82Overlapping toe (HP:0001845)2.04358293
83Abnormal trabecular bone morphology (HP:0100671)2.04161843
84Neoplasm of striated muscle (HP:0009728)2.03953434
85Ectopic kidney (HP:0000086)2.03909407
86Postnatal microcephaly (HP:0005484)2.01961926
87Broad distal phalanx of finger (HP:0009836)1.99442605
88Secondary amenorrhea (HP:0000869)1.98965881
89Abnormal protein glycosylation (HP:0012346)1.98649090
90Abnormal glycosylation (HP:0012345)1.98649090
91Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.98649090
92Abnormal protein N-linked glycosylation (HP:0012347)1.98649090
93Hyperacusis (HP:0010780)1.98439009
94Abnormality of the duodenum (HP:0002246)1.98438058
95Absent epiphyses (HP:0010577)1.97166523
96Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.97166523
97Type I transferrin isoform profile (HP:0003642)1.94147823
98Missing ribs (HP:0000921)1.93989208
99Sloping forehead (HP:0000340)1.92847539
100Proximal placement of thumb (HP:0009623)1.91258183
101Upper limb muscle weakness (HP:0003484)1.90874068
102Abnormal umbilical cord blood vessels (HP:0011403)1.90640995
103Single umbilical artery (HP:0001195)1.90640995
104Abnormality of the fetal cardiovascular system (HP:0010948)1.90640995
105Aplasia/hypoplasia of the humerus (HP:0006507)1.90521518
106Abnormality of reticulocytes (HP:0004312)1.87716896
107Increased nuchal translucency (HP:0010880)1.87441893
108Short thumb (HP:0009778)1.87345103
109Squamous cell carcinoma (HP:0002860)1.87051870
110Choanal atresia (HP:0000453)1.86179499
111Pelvic girdle muscle weakness (HP:0003749)1.84164788
112Deviation of the thumb (HP:0009603)1.81495437
113Facial cleft (HP:0002006)1.80782192
114Abnormalities of placenta or umbilical cord (HP:0001194)1.80126767
115Gout (HP:0001997)1.79752046
116Microvesicular hepatic steatosis (HP:0001414)1.78171638
117Amaurosis fugax (HP:0100576)1.77737361
118Septate vagina (HP:0001153)1.76743013
119Cholelithiasis (HP:0001081)1.76364378
120Abnormality of methionine metabolism (HP:0010901)1.75352823
121Abnormality of the carotid arteries (HP:0005344)1.74670493
122Small epiphyses (HP:0010585)1.73838439
123CNS hypomyelination (HP:0003429)1.73426010
124Hypoplasia of the capital femoral epiphysis (HP:0003090)1.72596334
125Shoulder girdle muscle weakness (HP:0003547)1.72098728
126Multiple enchondromatosis (HP:0005701)1.72059234
127Optic nerve coloboma (HP:0000588)1.70323981
128Rib fusion (HP:0000902)1.69721002
129Unilateral renal agenesis (HP:0000122)1.68892109
130Tetralogy of Fallot (HP:0001636)1.68082390
131Overriding aorta (HP:0002623)1.68004957
132Glossoptosis (HP:0000162)1.67416748
133Breast aplasia (HP:0100783)1.66452593
134Increased serum lactate (HP:0002151)1.65320877
135High anterior hairline (HP:0009890)1.65129799
136Sparse lateral eyebrow (HP:0005338)1.64792873
137Asplenia (HP:0001746)1.64729542
138Personality changes (HP:0000751)1.64301736
139Breech presentation (HP:0001623)1.59689318
140Orthostatic hypotension (HP:0001278)1.53584766
141Sparse eyelashes (HP:0000653)1.53105452
142Hypoplastic pelvis (HP:0008839)1.52921571
143Abnormal gallbladder morphology (HP:0012437)1.52876590
144Poikiloderma (HP:0001029)1.52319527
145Reticulocytosis (HP:0001923)1.52191636
146Generalized hypotonia (HP:0001290)1.52107963
147Pancreatic islet-cell hyperplasia (HP:0004510)1.51538809
148Renal duplication (HP:0000075)1.51195434

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.99218865
2WEE14.23178850
3CDC73.68581702
4TLK13.40268955
5TSSK63.21480610
6PBK3.17201848
7EIF2AK13.12761968
8SRPK13.10173986
9VRK22.67982663
10MKNK22.62649233
11MKNK12.62001909
12NME22.49052607
13NEK12.35687383
14NEK22.24648344
15SMG12.22185381
16TTK2.16751841
17PLK42.02270401
18PLK11.97375937
19STK161.94078268
20TESK21.87092524
21CDK71.75982508
22ACVR1B1.74979674
23PLK31.73927695
24PASK1.70029334
25EIF2AK31.68878096
26DYRK31.61700552
27BRSK21.60834353
28VRK11.59983805
29ATR1.54064756
30AURKB1.51993417
31AURKA1.43195621
32CDK121.42830803
33RPS6KB21.38838435
34EPHA21.35576145
35CHEK21.31919740
36AKT31.29237802
37BRSK11.23200124
38PNCK1.22246125
39EEF2K1.19289348
40CDK41.18999351
41TGFBR11.18429232
42MAP3K81.17696549
43ICK1.17230820
44CHEK11.15753943
45CCNB11.14532722
46MST1R1.11396354
47RPS6KA41.07120876
48TAF11.00676111
49IRAK30.95450399
50ALK0.93289885
51CDK20.91876290
52LATS20.90788034
53ZAK0.85904091
54MST40.84292327
55TRIB30.82486393
56BRAF0.81384740
57ERBB40.80889938
58PAK40.79929010
59ATM0.79043061
60PAK10.77574790
61STK100.77474441
62CSNK2A20.76599571
63TRIM280.75927993
64MAP3K110.75307460
65STK38L0.75282496
66SCYL20.73925551
67MAP3K100.72979699
68BCR0.72953711
69CSNK1G30.69451401
70BRD40.69169725
71CSNK2A10.68858240
72PRKCI0.68773804
73CLK10.68755759
74ARAF0.67829994
75RAF10.67111861
76MET0.66914916
77CDK80.65763149
78CSNK1A1L0.65703707
79NME10.64799956
80CDK10.63439125
81PIM10.61659624
82KSR20.59726513
83CDK90.59599562
84PIM20.58326000
85TESK10.58050474
86PDK20.57558807
87LATS10.55975066
88CSNK1G10.55767011
89STK40.54759008
90TAOK20.54090104
91CSNK1E0.54083351
92CDK150.52952619
93DYRK20.51885974
94EIF2AK20.51805408
95AKT20.48845561
96FLT30.48440766
97PDGFRA0.45051289
98PKN20.41154211
99KDR0.40757112
100PDK30.38096049
101PDK40.38096049
102PTK20.37872325
103FGFR40.37587803
104ILK0.37315945
105MTOR0.35346725
106LRRK20.34934959
107MAP4K10.33800961
108PRKDC0.33725320
109KSR10.32017545
110BMX0.31112145
111MELK0.29516347
112CDK60.28186817
113CDK140.27180990
114CDK190.24688862
115LIMK10.24664390
116CDK11A0.23011449
117DAPK10.22670177
118MAPK140.22403776
119RPS6KA50.21586008
120FGFR10.21077987
121MAPK90.20218456
122GRK60.19799522
123BCKDK0.19721409
124CSNK1D0.19156723
125YES10.18755434
126GSK3B0.18552018
127CDK180.18124193
128RPS6KC10.18036838

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.79970274
2Mismatch repair_Homo sapiens_hsa034304.13165963
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.92162153
4Ribosome_Homo sapiens_hsa030103.76720219
5RNA polymerase_Homo sapiens_hsa030203.65060894
6Spliceosome_Homo sapiens_hsa030403.64359148
7* RNA transport_Homo sapiens_hsa030133.33377981
8Proteasome_Homo sapiens_hsa030503.33099609
9Base excision repair_Homo sapiens_hsa034103.10376735
10Homologous recombination_Homo sapiens_hsa034402.96570570
11One carbon pool by folate_Homo sapiens_hsa006702.89249219
12Nucleotide excision repair_Homo sapiens_hsa034202.83203555
13Cell cycle_Homo sapiens_hsa041102.67946554
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.59741315
15Pyrimidine metabolism_Homo sapiens_hsa002402.48683571
16Fanconi anemia pathway_Homo sapiens_hsa034602.08078419
17mRNA surveillance pathway_Homo sapiens_hsa030151.95056392
18Basal transcription factors_Homo sapiens_hsa030221.93572072
19RNA degradation_Homo sapiens_hsa030181.83803323
20Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.74063582
21Non-homologous end-joining_Homo sapiens_hsa034501.73152919
22Pyruvate metabolism_Homo sapiens_hsa006201.61884820
23Steroid biosynthesis_Homo sapiens_hsa001001.52111100
24p53 signaling pathway_Homo sapiens_hsa041151.48955764
25Purine metabolism_Homo sapiens_hsa002301.44171809
26Fatty acid elongation_Homo sapiens_hsa000621.27523547
27Epstein-Barr virus infection_Homo sapiens_hsa051691.20999712
28Oocyte meiosis_Homo sapiens_hsa041141.14867157
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.13314043
30Biosynthesis of amino acids_Homo sapiens_hsa012300.98279643
31Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.96871404
32Propanoate metabolism_Homo sapiens_hsa006400.96785912
33Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.96095052
34Cyanoamino acid metabolism_Homo sapiens_hsa004600.91690054
35Thyroid cancer_Homo sapiens_hsa052160.90813785
36Systemic lupus erythematosus_Homo sapiens_hsa053220.90004698
37Cysteine and methionine metabolism_Homo sapiens_hsa002700.86445255
38Sulfur relay system_Homo sapiens_hsa041220.86133736
39Arginine and proline metabolism_Homo sapiens_hsa003300.85674617
40Viral carcinogenesis_Homo sapiens_hsa052030.84615150
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.84546783
42Vitamin B6 metabolism_Homo sapiens_hsa007500.82587429
43Pentose phosphate pathway_Homo sapiens_hsa000300.81846066
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.81418178
45Basal cell carcinoma_Homo sapiens_hsa052170.79317252
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77265389
47HTLV-I infection_Homo sapiens_hsa051660.76745133
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.74102463
49Folate biosynthesis_Homo sapiens_hsa007900.72709267
50Antigen processing and presentation_Homo sapiens_hsa046120.71574323
51Herpes simplex infection_Homo sapiens_hsa051680.70865494
52Fatty acid metabolism_Homo sapiens_hsa012120.70726254
53Huntingtons disease_Homo sapiens_hsa050160.69567846
54Hippo signaling pathway_Homo sapiens_hsa043900.66783297
55Lysine degradation_Homo sapiens_hsa003100.66441426
56Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59875698
57Arginine biosynthesis_Homo sapiens_hsa002200.59787232
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.56111721
59MicroRNAs in cancer_Homo sapiens_hsa052060.55625302
60Notch signaling pathway_Homo sapiens_hsa043300.55102615
61Hedgehog signaling pathway_Homo sapiens_hsa043400.52080360
62Selenocompound metabolism_Homo sapiens_hsa004500.51949210
63Protein export_Homo sapiens_hsa030600.49820664
64Carbon metabolism_Homo sapiens_hsa012000.48851293
65Colorectal cancer_Homo sapiens_hsa052100.48250982
66Phenylalanine metabolism_Homo sapiens_hsa003600.47572334
672-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.47380119
68Fructose and mannose metabolism_Homo sapiens_hsa000510.47246371
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46335547
70Parkinsons disease_Homo sapiens_hsa050120.45285494
71Alcoholism_Homo sapiens_hsa050340.41399062
72Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.40953091
73Drug metabolism - other enzymes_Homo sapiens_hsa009830.40937324
74Wnt signaling pathway_Homo sapiens_hsa043100.38845152
75N-Glycan biosynthesis_Homo sapiens_hsa005100.38475021
76Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37621490
77Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.37522477
78Central carbon metabolism in cancer_Homo sapiens_hsa052300.37236806
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36229582
80TGF-beta signaling pathway_Homo sapiens_hsa043500.35716340
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35022311
82Bladder cancer_Homo sapiens_hsa052190.34148005
83HIF-1 signaling pathway_Homo sapiens_hsa040660.33771750
84Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.33007393
85Small cell lung cancer_Homo sapiens_hsa052220.32995158
86Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.32923584
87Primary immunodeficiency_Homo sapiens_hsa053400.29119952
88Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.28463558
89Glutathione metabolism_Homo sapiens_hsa004800.27851598
90Vibrio cholerae infection_Homo sapiens_hsa051100.26127326
91Tyrosine metabolism_Homo sapiens_hsa003500.25518981
92Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.24959646
93Pathways in cancer_Homo sapiens_hsa052000.24751903
94Legionellosis_Homo sapiens_hsa051340.24227085
95Apoptosis_Homo sapiens_hsa042100.24060285
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.21995525
97Regulation of autophagy_Homo sapiens_hsa041400.21528087
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.21252271
99Acute myeloid leukemia_Homo sapiens_hsa052210.21196548
100Oxidative phosphorylation_Homo sapiens_hsa001900.20600797
101Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.20480127
102Alzheimers disease_Homo sapiens_hsa050100.20476287
103Galactose metabolism_Homo sapiens_hsa000520.19689040
104Hepatitis B_Homo sapiens_hsa051610.19059225
105Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.16959957
106Metabolic pathways_Homo sapiens_hsa011000.16724841
107Pancreatic cancer_Homo sapiens_hsa052120.16603398
108Prostate cancer_Homo sapiens_hsa052150.16338339
109Fatty acid biosynthesis_Homo sapiens_hsa000610.16109404
110Melanoma_Homo sapiens_hsa052180.16100469
111mTOR signaling pathway_Homo sapiens_hsa041500.16045862
112Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.15776788
113Chronic myeloid leukemia_Homo sapiens_hsa052200.15549988
114AMPK signaling pathway_Homo sapiens_hsa041520.15156081
115Viral myocarditis_Homo sapiens_hsa054160.14595148
116Non-small cell lung cancer_Homo sapiens_hsa052230.13122620
117Tight junction_Homo sapiens_hsa045300.12982074
118Endometrial cancer_Homo sapiens_hsa052130.12773015
119Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.12231837
120Adherens junction_Homo sapiens_hsa045200.11967989
121Measles_Homo sapiens_hsa051620.11781729
122Thyroid hormone signaling pathway_Homo sapiens_hsa049190.09035807
123Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.07595764
124PI3K-Akt signaling pathway_Homo sapiens_hsa041510.07199359
125Shigellosis_Homo sapiens_hsa051310.07072854
126Arachidonic acid metabolism_Homo sapiens_hsa005900.06578315

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