PRMT6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the arginine N-methyltransferase family, which catalyze the sequential transfer of methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins, to form methylated arginine derivatives and S-adenosyl-L-homocysteine. This protein can catalyze both, the formation of omega-N monomethylarginine and asymmetrical dimethylarginine, with a strong preference for the latter. It specifically mediates the asymmetric dimethylation of Arg2 of histone H3, and the methylated form represents a specific tag for epigenetic transcriptional repression. This protein also forms a complex with, and methylates DNA polymerase beta, resulting in stimulation of polymerase activity by enhancing DNA binding and processivity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)4.51748907
2DNA unwinding involved in DNA replication (GO:0006268)4.50212446
3maturation of SSU-rRNA (GO:0030490)4.43386589
4nucleobase biosynthetic process (GO:0046112)4.33420102
5formation of translation preinitiation complex (GO:0001731)4.30480594
6DNA replication initiation (GO:0006270)4.29005286
7DNA strand elongation involved in DNA replication (GO:0006271)4.26552568
8establishment of integrated proviral latency (GO:0075713)4.24910261
9purine nucleobase biosynthetic process (GO:0009113)4.23469669
10protein localization to kinetochore (GO:0034501)4.20476594
11mitotic metaphase plate congression (GO:0007080)4.20002759
12ribosome biogenesis (GO:0042254)4.18795970
13DNA strand elongation (GO:0022616)4.09061827
14folic acid-containing compound biosynthetic process (GO:0009396)4.05196808
15regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.88227223
16mitotic nuclear envelope disassembly (GO:0007077)3.85649773
17ribosomal small subunit assembly (GO:0000028)3.83277886
18viral transcription (GO:0019083)3.79485799
19viral mRNA export from host cell nucleus (GO:0046784)3.78673313
20translational termination (GO:0006415)3.78598983
21ribonucleoprotein complex biogenesis (GO:0022613)3.76347549
22nuclear pore organization (GO:0006999)3.76335011
23proline biosynthetic process (GO:0006561)3.76260125
24IMP biosynthetic process (GO:0006188)3.74890734
25DNA replication checkpoint (GO:0000076)3.72661082
26ribosome assembly (GO:0042255)3.68201754
27regulation of centriole replication (GO:0046599)3.66716907
28DNA replication-dependent nucleosome organization (GO:0034723)3.66458036
29DNA replication-dependent nucleosome assembly (GO:0006335)3.66458036
30protein localization to chromosome, centromeric region (GO:0071459)3.64785275
31regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.62280544
32translational initiation (GO:0006413)3.60190332
33nuclear envelope disassembly (GO:0051081)3.59252027
34membrane disassembly (GO:0030397)3.59252027
35telomere maintenance via semi-conservative replication (GO:0032201)3.53318180
36nuclear pore complex assembly (GO:0051292)3.52607333
37ribosomal large subunit biogenesis (GO:0042273)3.49733164
38negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.47277848
39regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.46278288
40DNA topological change (GO:0006265)3.44118415
41regulation of translational fidelity (GO:0006450)3.43916357
42metaphase plate congression (GO:0051310)3.43570078
43DNA replication-independent nucleosome organization (GO:0034724)3.42315453
44DNA replication-independent nucleosome assembly (GO:0006336)3.42315453
45translational elongation (GO:0006414)3.41188518
46nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.40795928
47protein complex localization (GO:0031503)3.40109882
48regulation of spindle organization (GO:0090224)3.38557166
49L-serine metabolic process (GO:0006563)3.35943049
50rRNA processing (GO:0006364)3.35662820
51IMP metabolic process (GO:0046040)3.35169042
52CENP-A containing nucleosome assembly (GO:0034080)3.33329218
53pseudouridine synthesis (GO:0001522)3.32009574
54establishment of viral latency (GO:0019043)3.31784276
55chromatin remodeling at centromere (GO:0031055)3.29921745
56mitotic chromosome condensation (GO:0007076)3.29816177
57* peptidyl-arginine omega-N-methylation (GO:0035247)3.28288285
58spliceosomal snRNP assembly (GO:0000387)3.27784741
59negative regulation of RNA splicing (GO:0033119)3.26502611
60folic acid metabolic process (GO:0046655)3.25769254
61rRNA metabolic process (GO:0016072)3.25142885
62rRNA transcription (GO:0009303)3.16154045
63telomere maintenance via recombination (GO:0000722)3.15898413
64regulation of mitochondrial translation (GO:0070129)3.13508411
65ribosomal small subunit biogenesis (GO:0042274)3.12819945
66chromatin assembly or disassembly (GO:0006333)3.11696023
67regulation of sister chromatid cohesion (GO:0007063)3.10516599
68negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.09073446
69pre-miRNA processing (GO:0031054)3.07238898
70SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.02044268
71positive regulation of chromosome segregation (GO:0051984)3.01037353
72regulation of double-strand break repair via homologous recombination (GO:0010569)3.00748753
73mitotic recombination (GO:0006312)3.00578630
74rRNA modification (GO:0000154)2.99910115
75cellular protein complex disassembly (GO:0043624)2.99604554
76DNA duplex unwinding (GO:0032508)2.98973316
77somatic diversification of immune receptors via somatic mutation (GO:0002566)2.98654577
78somatic hypermutation of immunoglobulin genes (GO:0016446)2.98654577
79cellular protein complex localization (GO:0034629)2.98649619
80DNA ligation (GO:0006266)2.96186211
81DNA geometric change (GO:0032392)2.95826757
82pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.95751026
83negative regulation of mRNA metabolic process (GO:1903312)2.95490755
84RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.94971070
85mRNA splicing, via spliceosome (GO:0000398)2.94971070
86RNA splicing, via transesterification reactions (GO:0000375)2.94900439
87regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.93337836
88protein targeting to ER (GO:0045047)2.91946550
89viral life cycle (GO:0019058)2.91452867
90histone exchange (GO:0043486)2.91171231
91cotranslational protein targeting to membrane (GO:0006613)2.90721191
92spliceosomal tri-snRNP complex assembly (GO:0000244)2.90060628
93anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.89018923
94nuclear envelope organization (GO:0006998)2.88546612
95histone H2A monoubiquitination (GO:0035518)2.88291182
96termination of RNA polymerase II transcription (GO:0006369)2.87715816
97negative regulation of histone methylation (GO:0031061)2.86984623
98sister chromatid segregation (GO:0000819)2.86822316
99pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.86712141
100negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.86693157
101negative regulation of ligase activity (GO:0051352)2.86693157
102regulation of chromosome segregation (GO:0051983)2.86281503
103negative regulation of mRNA processing (GO:0050686)2.86253677
104regulation of translational termination (GO:0006449)2.85746403
105regulation of RNA export from nucleus (GO:0046831)2.85548048
106pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.84717629
107* peptidyl-arginine methylation (GO:0018216)2.84374160
108* peptidyl-arginine N-methylation (GO:0035246)2.84374160
109mitotic G1 DNA damage checkpoint (GO:0031571)2.84078553
110maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.82662457
111tRNA aminoacylation for protein translation (GO:0006418)2.82354368
112mitotic sister chromatid segregation (GO:0000070)2.81896685
113protein complex disassembly (GO:0043241)2.81880498
114nuclear-transcribed mRNA catabolic process (GO:0000956)2.80443676
115negative regulation of chromosome segregation (GO:0051985)2.80344359
116dosage compensation (GO:0007549)2.79021933
117tRNA aminoacylation (GO:0043039)2.78985365
118amino acid activation (GO:0043038)2.78985365
119mitotic sister chromatid cohesion (GO:0007064)2.78903134
120establishment of protein localization to endoplasmic reticulum (GO:0072599)2.78571724
121protein localization to chromosome (GO:0034502)2.78085732
122pteridine-containing compound biosynthetic process (GO:0042559)2.78018081
123telomere maintenance via telomere lengthening (GO:0010833)2.77353529
124* histone arginine methylation (GO:0034969)2.77326369
125nucleotide-excision repair, DNA gap filling (GO:0006297)2.77091982
126pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.75714508
127heterochromatin organization (GO:0070828)2.75610971
128ATP-dependent chromatin remodeling (GO:0043044)2.74952737
129establishment of chromosome localization (GO:0051303)2.74875969
130CTP biosynthetic process (GO:0006241)2.74692955
131CTP metabolic process (GO:0046036)2.74692955
132positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.74135498
133regulation of mitotic spindle organization (GO:0060236)2.74082821
134maturation of 5.8S rRNA (GO:0000460)2.73396152
135pore complex assembly (GO:0046931)2.72939329
136protein localization to endoplasmic reticulum (GO:0070972)2.71351011
137negative regulation of mitotic sister chromatid separation (GO:2000816)2.70457517
138negative regulation of mitotic sister chromatid segregation (GO:0033048)2.70457517
139negative regulation of sister chromatid segregation (GO:0033046)2.70457517
140* base-excision repair (GO:0006284)2.68173093
141serine family amino acid biosynthetic process (GO:0009070)2.68139038
142peptidyl-histidine modification (GO:0018202)2.67148780
143pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.65695690
144biotin metabolic process (GO:0006768)2.63204643
145nucleobase-containing small molecule interconversion (GO:0015949)2.62328038
146mitochondrial RNA metabolic process (GO:0000959)2.60471864
147regulation of mammary gland epithelial cell proliferation (GO:0033599)2.58715413

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.14732541
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.19989931
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.76866526
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.62650936
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.19716464
6MYC_19079543_ChIP-ChIP_MESCs_Mouse2.90743280
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.81589696
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.72484940
9MYC_19030024_ChIP-ChIP_MESCs_Mouse2.70326317
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.66442845
11MYC_22102868_ChIP-Seq_BL_Human2.65400694
12* ETS1_20019798_ChIP-Seq_JURKAT_Human2.46977850
13XRN2_22483619_ChIP-Seq_HELA_Human2.44238052
14ESR1_15608294_ChIP-ChIP_MCF-7_Human2.37305112
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.33857242
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.33820333
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.31211674
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.29956652
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.29734649
20* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.17099768
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.16457261
22EST1_17652178_ChIP-ChIP_JURKAT_Human2.16418984
23VDR_23849224_ChIP-Seq_CD4+_Human2.00221002
24RBPJ_22232070_ChIP-Seq_NCS_Mouse1.95888645
25MYCN_18555785_ChIP-Seq_MESCs_Mouse1.94619827
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.93358731
27GABP_19822575_ChIP-Seq_HepG2_Human1.93158677
28E2F1_21310950_ChIP-Seq_MCF-7_Human1.85709084
29AR_21909140_ChIP-Seq_LNCAP_Human1.82273098
30DCP1A_22483619_ChIP-Seq_HELA_Human1.81169522
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.80988059
32FOXP3_21729870_ChIP-Seq_TREG_Human1.80028149
33* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.79030549
34TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.78898744
35SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.78335546
36* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.77705121
37CIITA_25753668_ChIP-Seq_RAJI_Human1.73201238
38NOTCH1_21737748_ChIP-Seq_TLL_Human1.72772255
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.70165858
40TTF2_22483619_ChIP-Seq_HELA_Human1.69551357
41VDR_21846776_ChIP-Seq_THP-1_Human1.69082988
42ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.65689426
43KDM5A_27292631_Chip-Seq_BREAST_Human1.65325823
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.65062005
45NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.64726942
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64500447
47* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.59789956
48KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.58624393
49PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.57163465
50NANOG_18555785_ChIP-Seq_MESCs_Mouse1.53683487
51KLF4_18555785_ChIP-Seq_MESCs_Mouse1.51976712
52* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.51814658
53SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.49979788
54NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.44721772
55FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.42311611
56PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.41827702
57CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.41366925
58CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.39530316
59TP63_19390658_ChIP-ChIP_HaCaT_Human1.38555634
60SRF_21415370_ChIP-Seq_HL-1_Mouse1.38180074
61STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.37559147
62STAT3_1855785_ChIP-Seq_MESCs_Mouse1.34620534
63POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.33899839
64YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32252466
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31570715
66SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.29778773
67CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.28753072
68* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.26225717
69TFEB_21752829_ChIP-Seq_HELA_Human1.26148117
70HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.26012438
71ERG_20887958_ChIP-Seq_HPC-7_Mouse1.24011848
72* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.22382021
73YY1_21170310_ChIP-Seq_MESCs_Mouse1.22372963
74ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.21040479
75SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.20879551
76ELF1_17652178_ChIP-ChIP_JURKAT_Human1.19995354
77SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.19155910
78CHD1_26751641_Chip-Seq_LNCaP_Human1.18879270
79ELK1_19687146_ChIP-ChIP_HELA_Human1.17997191
80FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17454293
81CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.16077740
82KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.14926242
83GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.11526956
84POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.11243735
85TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10105648
86HIF1A_21447827_ChIP-Seq_MCF-7_Human1.07746711
87ESR1_21235772_ChIP-Seq_MCF-7_Human1.07431118
88MYC_18940864_ChIP-ChIP_HL60_Human1.06119394
89SPI1_23547873_ChIP-Seq_NB4_Human1.04709749
90KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04666960
91UTX_26944678_Chip-Seq_JUKART_Human1.04653652
92TCF7_22412390_ChIP-Seq_EML_Mouse1.04407340
93SOX2_16153702_ChIP-ChIP_HESCs_Human1.04062827
94* MAF_26560356_Chip-Seq_TH1_Human1.00303830
95SOX2_18555785_ChIP-Seq_MESCs_Mouse1.00198338
96DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.99893020
97NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.99551585
98NANOG_21062744_ChIP-ChIP_HESCs_Human0.97633409
99SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.97410806
100NANOG_16153702_ChIP-ChIP_HESCs_Human0.97077497
101* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96091104
102ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.94307703
103* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.93371811
104SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.93255359
105FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.92543387
106MYB_26560356_Chip-Seq_TH1_Human0.92043745
107CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.91978335
108ZNF263_19887448_ChIP-Seq_K562_Human0.91641363
109TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.90922802
110SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.90883920
111TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.90025074
112MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.89792939
113TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.89465881
114* ELK3_25401928_ChIP-Seq_HUVEC_Human0.88058089
115PADI4_21655091_ChIP-ChIP_MCF-7_Human0.87545416
116* MAF_26560356_Chip-Seq_TH2_Human0.87223773
117BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.86760403
118SOX17_20123909_ChIP-Seq_XEN_Mouse0.85713132
119MYB_21317192_ChIP-Seq_ERMYB_Mouse0.85494991
120MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.85455896
121TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.84888201
122* KDM2B_26808549_Chip-Seq_DND41_Human0.83954506
123MYB_26560356_Chip-Seq_TH2_Human0.83642762

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.70162635
2MP0004957_abnormal_blastocyst_morpholog4.08316003
3MP0010094_abnormal_chromosome_stability3.93184148
4MP0003111_abnormal_nucleus_morphology3.79145767
5MP0003077_abnormal_cell_cycle3.76944528
6MP0008057_abnormal_DNA_replication3.35288066
7MP0002396_abnormal_hematopoietic_system3.07563060
8MP0008007_abnormal_cellular_replicative2.99787091
9MP0003123_paternal_imprinting2.70339717
10MP0001730_embryonic_growth_arrest2.54653778
11MP0008058_abnormal_DNA_repair2.44792252
12MP0003941_abnormal_skin_development2.41819847
13MP0010352_gastrointestinal_tract_polyps2.33773559
14MP0000350_abnormal_cell_proliferation2.31982408
15MP0008932_abnormal_embryonic_tissue2.20201188
16MP0010307_abnormal_tumor_latency2.18179145
17MP0010030_abnormal_orbit_morphology2.12520212
18MP0001697_abnormal_embryo_size1.94279603
19MP0005076_abnormal_cell_differentiation1.92259936
20MP0002796_impaired_skin_barrier1.92044180
21MP0005380_embryogenesis_phenotype1.87668405
22MP0001672_abnormal_embryogenesis/_devel1.87668405
23MP0000490_abnormal_crypts_of1.84980821
24MP0009333_abnormal_splenocyte_physiolog1.84729339
25MP0003984_embryonic_growth_retardation1.80687999
26MP0004808_abnormal_hematopoietic_stem1.80083702
27MP0002088_abnormal_embryonic_growth/wei1.77964258
28MP0002084_abnormal_developmental_patter1.77293498
29MP0002080_prenatal_lethality1.74429128
30MP0002085_abnormal_embryonic_tissue1.74110285
31MP0003315_abnormal_perineum_morphology1.69148672
32MP0002086_abnormal_extraembryonic_tissu1.68367276
33MP0005501_abnormal_skin_physiology1.65268513
34MP0003763_abnormal_thymus_physiology1.64121373
35MP0009697_abnormal_copulation1.58998904
36MP0001293_anophthalmia1.57751169
37MP0002009_preneoplasia1.57412548
38MP0003303_peritoneal_inflammation1.57392497
39MP0004197_abnormal_fetal_growth/weight/1.57091517
40MP0000462_abnormal_digestive_system1.52802734
41MP0004233_abnormal_muscle_weight1.50911517
42MP0002019_abnormal_tumor_incidence1.50621671
43MP0000313_abnormal_cell_death1.48311499
44MP0002398_abnormal_bone_marrow1.47453817
45MP0001727_abnormal_embryo_implantation1.46305137
46MP0004264_abnormal_extraembryonic_tissu1.44424265
47MP0003786_premature_aging1.42915786
48MP0000703_abnormal_thymus_morphology1.42605048
49MP0005397_hematopoietic_system_phenotyp1.38655594
50MP0001545_abnormal_hematopoietic_system1.38655594
51MP0006035_abnormal_mitochondrial_morpho1.38151984
52MP0000579_abnormal_nail_morphology1.37715052
53MP0001529_abnormal_vocalization1.37286642
54MP0008995_early_reproductive_senescence1.32028329
55MP0000689_abnormal_spleen_morphology1.31444079
56MP0002722_abnormal_immune_system1.31250170
57MP0008877_abnormal_DNA_methylation1.29137978
58MP0002098_abnormal_vibrissa_morphology1.27259934
59MP0003567_abnormal_fetal_cardiomyocyte1.26676863
60MP0002697_abnormal_eye_size1.25609958
61MP0003942_abnormal_urinary_system1.24454693
62MP0002751_abnormal_autonomic_nervous1.23152157
63MP0003937_abnormal_limbs/digits/tail_de1.19337048
64MP0003119_abnormal_digestive_system1.19332335
65MP0002653_abnormal_ependyma_morphology1.17231566
66MP0002160_abnormal_reproductive_system1.16815475
67MP0003806_abnormal_nucleotide_metabolis1.15041638
68MP0009278_abnormal_bone_marrow1.13931437
69MP0003121_genomic_imprinting1.13788319
70MP0001346_abnormal_lacrimal_gland1.11518217
71MP0003221_abnormal_cardiomyocyte_apopto1.11035645
72MP0002429_abnormal_blood_cell1.09670879
73MP0002249_abnormal_larynx_morphology1.05738779
74MP0009672_abnormal_birth_weight1.04703063
75MP0003890_abnormal_embryonic-extraembry1.02864920
76MP0000627_abnormal_mammary_gland1.02851362
77MP0000716_abnormal_immune_system1.01797357
78MP0001800_abnormal_humoral_immune0.99333042
79MP0002877_abnormal_melanocyte_morpholog0.99197666
80MP0001915_intracranial_hemorrhage0.96752188
81MP0003705_abnormal_hypodermis_morpholog0.96217566
82MP0009053_abnormal_anal_canal0.94131849
83MP0002092_abnormal_eye_morphology0.93960734
84MP0000428_abnormal_craniofacial_morphol0.93122596
85MP0001145_abnormal_male_reproductive0.92357090
86MP0002938_white_spotting0.91515030
87MP0006292_abnormal_olfactory_placode0.91334278
88MP0005621_abnormal_cell_physiology0.91262253
89MP0002210_abnormal_sex_determination0.90464730
90MP0001919_abnormal_reproductive_system0.90193181
91MP0000358_abnormal_cell_content/0.89323892
92MP0000465_gastrointestinal_hemorrhage0.89211206
93MP0000049_abnormal_middle_ear0.88963083
94MP0000733_abnormal_muscle_development0.87488878
95MP0005384_cellular_phenotype0.87162802
96MP0000685_abnormal_immune_system0.85342219
97MP0008770_decreased_survivor_rate0.85242472
98MP0000383_abnormal_hair_follicle0.85096545
99MP0000477_abnormal_intestine_morphology0.85011270
100MP0003186_abnormal_redox_activity0.84684676
101MP0001881_abnormal_mammary_gland0.84438038
102MP0003787_abnormal_imprinting0.84120773
103MP0002420_abnormal_adaptive_immunity0.84116598
104MP0000537_abnormal_urethra_morphology0.83795513
105MP0001286_abnormal_eye_development0.83721957
106MP0002452_abnormal_antigen_presenting0.82273497
107MP0001819_abnormal_immune_cell0.81948031
108MP0001849_ear_inflammation0.81838067
109MP0000858_altered_metastatic_potential0.81131786
110MP0001835_abnormal_antigen_presentation0.80562489
111MP0004782_abnormal_surfactant_physiolog0.80364994
112MP0009703_decreased_birth_body0.79623497
113MP0004133_heterotaxia0.78775217
114MP0005075_abnormal_melanosome_morpholog0.78629172
115MP0000377_abnormal_hair_follicle0.78551231
116MP0003936_abnormal_reproductive_system0.78130618
117MP0009384_cardiac_valve_regurgitation0.77798646
118MP0002111_abnormal_tail_morphology0.77634661
119MP0002723_abnormal_immune_serum0.76251009
120MP0001340_abnormal_eyelid_morphology0.76043844
121MP0002405_respiratory_system_inflammati0.76029011
122MP0002075_abnormal_coat/hair_pigmentati0.74411977
123MP0003283_abnormal_digestive_organ0.73550109
124MP0005671_abnormal_response_to0.73328686
125MP0000653_abnormal_sex_gland0.71520323
126MP0010234_abnormal_vibrissa_follicle0.70241099
127MP0003718_maternal_effect0.69043276
128MP0001188_hyperpigmentation0.68816311
129MP0003122_maternal_imprinting0.68380224
130MP0002932_abnormal_joint_morphology0.68319981
131MP0001929_abnormal_gametogenesis0.67888519
132MP0004185_abnormal_adipocyte_glucose0.66296968
133MP0003861_abnormal_nervous_system0.65133646
134MP0003943_abnormal_hepatobiliary_system0.65023527
135MP0003935_abnormal_craniofacial_develop0.64060125
136MP0005220_abnormal_exocrine_pancreas0.62172289
137MP0002925_abnormal_cardiovascular_devel0.61054272
138MP0001119_abnormal_female_reproductive0.60385084
139MP0000432_abnormal_head_morphology0.58394310
140MP0001348_abnormal_lacrimal_gland0.58237494
141MP0000371_diluted_coat_color0.57934354
142MP0006054_spinal_hemorrhage0.56367907
143MP0003115_abnormal_respiratory_system0.56252412
144MP0002114_abnormal_axial_skeleton0.56188708

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.40935905
2Facial hemangioma (HP:0000329)3.81238790
3Septate vagina (HP:0001153)3.61626904
4Microvesicular hepatic steatosis (HP:0001414)3.58157688
5Colon cancer (HP:0003003)3.42567749
6Asymmetry of the thorax (HP:0001555)3.34015840
7Reticulocytopenia (HP:0001896)3.27976820
8Breast hypoplasia (HP:0003187)3.18585434
9Abnormality of cells of the erythroid lineage (HP:0012130)3.15252868
10Patellar aplasia (HP:0006443)3.13176014
11Microglossia (HP:0000171)3.11575728
12Abnormality of the anterior horn cell (HP:0006802)3.10539639
13Degeneration of anterior horn cells (HP:0002398)3.10539639
14Abnormal number of erythroid precursors (HP:0012131)3.05294957
15Multiple enchondromatosis (HP:0005701)3.03669559
16Selective tooth agenesis (HP:0001592)2.98167945
17Nephroblastoma (Wilms tumor) (HP:0002667)2.97340956
18Aplasia/Hypoplasia of the patella (HP:0006498)2.88323560
19Embryonal renal neoplasm (HP:0011794)2.84946035
20Thrombocytosis (HP:0001894)2.79410744
21Ependymoma (HP:0002888)2.75341298
22Broad distal phalanx of finger (HP:0009836)2.72285805
23Basal cell carcinoma (HP:0002671)2.71921974
24Overlapping toe (HP:0001845)2.64565002
25Proximal placement of thumb (HP:0009623)2.62952799
26Carpal bone hypoplasia (HP:0001498)2.62832482
27Absent thumb (HP:0009777)2.59646804
28Concave nail (HP:0001598)2.58332228
29Aplastic anemia (HP:0001915)2.57033728
30Rough bone trabeculation (HP:0100670)2.56717590
31Microretrognathia (HP:0000308)2.51443828
32Trismus (HP:0000211)2.44450001
33Deviation of the thumb (HP:0009603)2.43965995
34Capillary hemangiomas (HP:0005306)2.43121683
35Oral leukoplakia (HP:0002745)2.41149074
36Atrophy/Degeneration involving motor neurons (HP:0007373)2.40741079
37Abnormality of the carotid arteries (HP:0005344)2.40262891
38Pallor (HP:0000980)2.39225446
39Breast carcinoma (HP:0003002)2.38994780
40Slender long bone (HP:0003100)2.38494994
41Prominent nose (HP:0000448)2.37651802
42Abnormality of the umbilical cord (HP:0010881)2.37445220
43Medulloblastoma (HP:0002885)2.34786155
44Atresia of the external auditory canal (HP:0000413)2.34249250
45Myelodysplasia (HP:0002863)2.32660846
46Abnormal lung lobation (HP:0002101)2.32481153
47J-shaped sella turcica (HP:0002680)2.31560674
48Triphalangeal thumb (HP:0001199)2.28003070
49Type I transferrin isoform profile (HP:0003642)2.27652577
50Cerebral hypomyelination (HP:0006808)2.26584700
51Rhabdomyosarcoma (HP:0002859)2.25439236
52Neoplasm of the pancreas (HP:0002894)2.25150080
53Progressive muscle weakness (HP:0003323)2.24894032
54Macrocytic anemia (HP:0001972)2.24821641
55Premature graying of hair (HP:0002216)2.24309460
56Rib fusion (HP:0000902)2.23758730
57Missing ribs (HP:0000921)2.23439666
58Meckel diverticulum (HP:0002245)2.23302796
59Single umbilical artery (HP:0001195)2.21523453
60Abnormality of the fetal cardiovascular system (HP:0010948)2.21523453
61Abnormal umbilical cord blood vessels (HP:0011403)2.21523453
62Agnosia (HP:0010524)2.21424351
63Testicular atrophy (HP:0000029)2.20439237
64Abnormality of the ileum (HP:0001549)2.20253481
65Renal duplication (HP:0000075)2.20046419
66Aplasia/Hypoplasia of the uvula (HP:0010293)2.18303179
67Glossoptosis (HP:0000162)2.15477313
68Abnormality of the labia minora (HP:0012880)2.15369619
69Hyperglycinuria (HP:0003108)2.14775840
70Supernumerary spleens (HP:0009799)2.14765750
71Abnormal number of incisors (HP:0011064)2.12460552
72Spinal cord lesions (HP:0100561)2.08482967
73Syringomyelia (HP:0003396)2.08482967
74Facial cleft (HP:0002006)2.08291013
75Sparse lateral eyebrow (HP:0005338)2.08287883
76Micronodular cirrhosis (HP:0001413)2.07641406
77Cutaneous melanoma (HP:0012056)2.06841431
78Poikiloderma (HP:0001029)2.06288846
79Chromosomal breakage induced by crosslinking agents (HP:0003221)2.05947595
80Entropion (HP:0000621)2.05499249
81Pelvic girdle muscle weakness (HP:0003749)2.04053119
82Short middle phalanx of the 5th finger (HP:0004220)2.03665098
83Absent radius (HP:0003974)2.03334556
84Generalized hypotonia (HP:0001290)2.02116573
85Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.02113711
86Hyperacusis (HP:0010780)2.00886472
87Chromsome breakage (HP:0040012)2.00737877
88Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.00735354
89Abnormal protein N-linked glycosylation (HP:0012347)2.00735354
90Abnormal protein glycosylation (HP:0012346)2.00735354
91Abnormal glycosylation (HP:0012345)2.00735354
92Tracheoesophageal fistula (HP:0002575)2.00432991
93Abnormality of chromosome stability (HP:0003220)1.98785134
94Acute lymphatic leukemia (HP:0006721)1.98610295
95Increased nuchal translucency (HP:0010880)1.97044364
96Horseshoe kidney (HP:0000085)1.94266704
97Embryonal neoplasm (HP:0002898)1.92861861
98Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.92640893
99Squamous cell carcinoma (HP:0002860)1.91909584
100Oligodactyly (HP:0012165)1.91497637
101Aplasia/Hypoplasia of the sternum (HP:0006714)1.90967151
102Genu recurvatum (HP:0002816)1.90394708
103Lymphoma (HP:0002665)1.90366103
104Short 4th metacarpal (HP:0010044)1.89266899
105Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.89266899
106Aplasia involving forearm bones (HP:0009822)1.89055043
107Absent forearm bone (HP:0003953)1.89055043
10811 pairs of ribs (HP:0000878)1.87634904
109Abnormality of the preputium (HP:0100587)1.87203917
110Cellular immunodeficiency (HP:0005374)1.86808616
111Amaurosis fugax (HP:0100576)1.85989286
112Abnormal trabecular bone morphology (HP:0100671)1.84522214
113Reduced antithrombin III activity (HP:0001976)1.84360179
114Neoplasm of the adrenal gland (HP:0100631)1.83464611
115Neoplasm of striated muscle (HP:0009728)1.82695197
116IgM deficiency (HP:0002850)1.81339697
117Pancytopenia (HP:0001876)1.80414506
118Increased hepatocellular lipid droplets (HP:0006565)1.80098761
119Astrocytoma (HP:0009592)1.80078039
120Abnormality of the astrocytes (HP:0100707)1.80078039
121Progressive external ophthalmoplegia (HP:0000590)1.79850551
122Absent frontal sinuses (HP:0002688)1.79469973
123Lipid accumulation in hepatocytes (HP:0006561)1.79451518
124Abnormality of reticulocytes (HP:0004312)1.79443226
125Abnormality of T cell physiology (HP:0011840)1.78784083
126Cortical dysplasia (HP:0002539)1.78686645
127Spastic diplegia (HP:0001264)1.78523078
128Small intestinal stenosis (HP:0012848)1.78433754
129Duodenal stenosis (HP:0100867)1.78433754
130Abnormality of serine family amino acid metabolism (HP:0010894)1.78325840
131Abnormality of glycine metabolism (HP:0010895)1.78325840
132Hyperglycinemia (HP:0002154)1.77536928
133Skin tags (HP:0010609)1.77331977
134Aplasia/Hypoplasia of the sacrum (HP:0008517)1.76486125
135Increased density of long bones (HP:0006392)1.76373953
136Termporal pattern (HP:0011008)1.76275228
137Insidious onset (HP:0003587)1.76275228
138Abnormality of the distal phalanges of the toes (HP:0010182)1.76090088
139Abnormality of the duodenum (HP:0002246)1.75834677
140High anterior hairline (HP:0009890)1.75096797
141Cafe-au-lait spot (HP:0000957)1.74927774
142Overriding aorta (HP:0002623)1.74295776
143Abnormality of glycolysis (HP:0004366)1.74074097
144Postnatal microcephaly (HP:0005484)1.73187420
145Preauricular skin tag (HP:0000384)1.72826478
146Long eyelashes (HP:0000527)1.72401119
147Impulsivity (HP:0100710)1.72075061
148Abnormality of T cells (HP:0002843)1.71783558
149Neoplasm of the adrenal cortex (HP:0100641)1.71562238
150Broad alveolar ridges (HP:0000187)1.71519541
151Abnormal neuron morphology (HP:0012757)1.71292290
152Abnormality of the motor neurons (HP:0002450)1.71292290
153Thyroid carcinoma (HP:0002890)1.70330106
154Short thumb (HP:0009778)1.70302323
155Deep philtrum (HP:0002002)1.69751957
156High pitched voice (HP:0001620)1.68843747
157Hypoparathyroidism (HP:0000829)1.68227581
158Arteriovenous malformation (HP:0100026)1.67433556
159Bone marrow hypocellularity (HP:0005528)1.67018567
160CNS hypomyelination (HP:0003429)1.64532774
161Duplication of thumb phalanx (HP:0009942)1.62946842

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.90035492
2WEE13.57897062
3CDC73.39879977
4BUB13.27014299
5NEK23.05183371
6SMG12.87230695
7PBK2.84791146
8MAP4K12.60834180
9DYRK32.56305165
10PKN22.50075154
11FLT32.30442866
12CDK122.27311682
13EEF2K2.23532063
14NME22.19919227
15ACVR1B2.15133363
16EIF2AK12.11125541
17TAF12.07019774
18RPS6KA42.02642446
19MAP3K102.01654677
20PIM21.94266663
21TESK21.92980545
22LATS21.91540579
23SCYL21.90805297
24SRPK11.88695863
25CDK71.73113055
26BCKDK1.70284306
27TRIB31.67411568
28BRSK21.67013796
29ZAK1.64965835
30RPS6KB21.63453136
31TRIM281.63110605
32PLK11.60161787
33TLK11.44826606
34PASK1.43281333
35CDK41.38159647
36AURKB1.33588794
37MAP3K81.33514545
38MKNK11.32266685
39ATR1.24690340
40TESK11.20776781
41RAF11.19979705
42TTK1.19469371
43PIM11.18770035
44MAP3K111.18630166
45STK101.18517366
46EIF2AK21.17171827
47SIK11.16816080
48EPHA21.15961682
49CHEK21.14505688
50PIK3CA1.14139312
51JAK31.13882859
52CHEK11.10359339
53MKNK21.09849367
54ALK1.04665334
55TGFBR11.03660962
56ZAP701.02119570
57VRK11.01850404
58MAP2K21.00830694
59PAK41.00147995
60AURKA0.98708612
61EIF2AK30.98228953
62NEK60.97421664
63MUSK0.97275852
64CSF1R0.95666700
65STK30.95513533
66NEK10.95470212
67TSSK60.94884832
68CCNB10.94563723
69ERN10.92269408
70NUAK10.90995743
71IRAK30.87682552
72CDK80.87482017
73PLK40.86449122
74MAP2K70.85157871
75BRSK10.84456320
76NME10.82841472
77PLK30.80755405
78GRK60.78760755
79CDK20.77815738
80LATS10.76802821
81DYRK20.74912423
82TAOK10.73922246
83LRRK20.73580635
84MTOR0.71975710
85KIT0.71846371
86DAPK10.71284849
87BLK0.70975046
88PAK10.68715765
89PAK20.67645874
90CDK60.66425016
91RPS6KB10.65606810
92ILK0.65184057
93CSNK1G30.64712952
94STK160.64025107
95STK38L0.63311012
96MAP2K30.60121584
97KDR0.59396667
98IRAK20.58517121
99MAP3K120.58048263
100ATM0.57323795
101CSNK1G10.55942841
102DYRK1B0.53363423
103TYRO30.51975813
104BCR0.51520214
105KSR10.48583394
106CDK10.46990646
107CSNK2A20.46984077
108PDGFRA0.46889198
109PTK60.45313215
110PRKCI0.45189945
111AKT20.44447638
112BTK0.43726507
113ICK0.43280906
114RPS6KA50.42953852
115TBK10.42849929
116MAPK110.41810136
117LIMK10.40020449
118MELK0.39778226
119BRD40.39393102
120CLK10.38535032
121CSNK1G20.38266654
122MAPKAPK30.37413072
123BRAF0.36423685
124CSNK1E0.35982966
125YES10.35953141
126SIK30.35831333
127ADRBK20.34959800
128WNK30.34594883
129CSNK2A10.34380113
130MARK30.33827449
131TXK0.33242899
132CSNK1A1L0.32694944
133NLK0.32590348
134CHUK0.32466936
135STK40.32191102
136LYN0.31958050
137HIPK20.31522314
138CDK180.30209326
139RPS6KC10.29429077

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.30444543
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.78504630
3Mismatch repair_Homo sapiens_hsa034303.45685927
4Spliceosome_Homo sapiens_hsa030403.28041215
5RNA transport_Homo sapiens_hsa030133.21905310
6Ribosome_Homo sapiens_hsa030102.98611911
7Cell cycle_Homo sapiens_hsa041102.98234201
8RNA polymerase_Homo sapiens_hsa030202.88591710
9Base excision repair_Homo sapiens_hsa034102.75396660
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.41340754
11One carbon pool by folate_Homo sapiens_hsa006702.37294299
12Homologous recombination_Homo sapiens_hsa034402.29887256
13Nucleotide excision repair_Homo sapiens_hsa034202.24413225
14Pyrimidine metabolism_Homo sapiens_hsa002402.07831102
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.02317967
16Proteasome_Homo sapiens_hsa030501.90854902
17mRNA surveillance pathway_Homo sapiens_hsa030151.88624172
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.87898428
19p53 signaling pathway_Homo sapiens_hsa041151.86519331
20RNA degradation_Homo sapiens_hsa030181.69070447
21Fanconi anemia pathway_Homo sapiens_hsa034601.68318767
22Basal transcription factors_Homo sapiens_hsa030221.67953532
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.53538552
24Fatty acid elongation_Homo sapiens_hsa000621.51524874
25Herpes simplex infection_Homo sapiens_hsa051681.36690287
26Epstein-Barr virus infection_Homo sapiens_hsa051691.30514917
27Sulfur relay system_Homo sapiens_hsa041221.26293805
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.24536797
29Pentose phosphate pathway_Homo sapiens_hsa000301.24331137
30Viral carcinogenesis_Homo sapiens_hsa052031.24113395
31Steroid biosynthesis_Homo sapiens_hsa001001.23419806
32Folate biosynthesis_Homo sapiens_hsa007901.19570003
33Systemic lupus erythematosus_Homo sapiens_hsa053221.17397224
34Non-homologous end-joining_Homo sapiens_hsa034501.17360499
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.16336607
36Oocyte meiosis_Homo sapiens_hsa041141.14497211
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.14122170
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.10728586
39Primary immunodeficiency_Homo sapiens_hsa053401.03737801
40Biosynthesis of amino acids_Homo sapiens_hsa012301.03709241
41Protein export_Homo sapiens_hsa030601.03384188
42Antigen processing and presentation_Homo sapiens_hsa046121.02500037
43HTLV-I infection_Homo sapiens_hsa051661.02096505
44Parkinsons disease_Homo sapiens_hsa050121.01360367
45Pyruvate metabolism_Homo sapiens_hsa006201.00995387
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.99377970
47Chronic myeloid leukemia_Homo sapiens_hsa052200.99360838
48Thyroid cancer_Homo sapiens_hsa052160.98757259
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.97819828
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.96705405
51Small cell lung cancer_Homo sapiens_hsa052220.96527898
52Purine metabolism_Homo sapiens_hsa002300.94694820
53Propanoate metabolism_Homo sapiens_hsa006400.93321164
54MicroRNAs in cancer_Homo sapiens_hsa052060.92188314
55Oxidative phosphorylation_Homo sapiens_hsa001900.90453746
56Huntingtons disease_Homo sapiens_hsa050160.90310743
57Selenocompound metabolism_Homo sapiens_hsa004500.87973004
58Hepatitis B_Homo sapiens_hsa051610.86540668
59Colorectal cancer_Homo sapiens_hsa052100.86444713
60Vitamin B6 metabolism_Homo sapiens_hsa007500.84800568
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83897056
62Transcriptional misregulation in cancer_Homo sapiens_hsa052020.83694676
63Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.83442559
64Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.82730050
65mTOR signaling pathway_Homo sapiens_hsa041500.82438170
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.80927317
67Legionellosis_Homo sapiens_hsa051340.79349185
68Shigellosis_Homo sapiens_hsa051310.78718287
69Fructose and mannose metabolism_Homo sapiens_hsa000510.77627871
70Notch signaling pathway_Homo sapiens_hsa043300.76827990
71Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.73658304
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.73274175
73B cell receptor signaling pathway_Homo sapiens_hsa046620.72396932
74Glutathione metabolism_Homo sapiens_hsa004800.69437421
75Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.69122489
76Measles_Homo sapiens_hsa051620.69057061
77Acute myeloid leukemia_Homo sapiens_hsa052210.68752195
78Apoptosis_Homo sapiens_hsa042100.68225357
79Hippo signaling pathway_Homo sapiens_hsa043900.66070039
80Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.65050276
81NF-kappa B signaling pathway_Homo sapiens_hsa040640.64367018
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63276645
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.63015014
84Lysine degradation_Homo sapiens_hsa003100.62891202
85Pancreatic cancer_Homo sapiens_hsa052120.62344778
86Central carbon metabolism in cancer_Homo sapiens_hsa052300.62252232
87Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59777068
88Bladder cancer_Homo sapiens_hsa052190.58376594
89Metabolic pathways_Homo sapiens_hsa011000.57328915
90Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56769468
91Vitamin digestion and absorption_Homo sapiens_hsa049770.56498371
92Viral myocarditis_Homo sapiens_hsa054160.55878975
93Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.55838440
94N-Glycan biosynthesis_Homo sapiens_hsa005100.55516275
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55513499
96Basal cell carcinoma_Homo sapiens_hsa052170.55485797
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54937738
98RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.52584549
99Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.52226072
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.50986016
101Fatty acid metabolism_Homo sapiens_hsa012120.50398644
102TGF-beta signaling pathway_Homo sapiens_hsa043500.50346510
103Alcoholism_Homo sapiens_hsa050340.50308045
104Hedgehog signaling pathway_Homo sapiens_hsa043400.49635118
105Non-small cell lung cancer_Homo sapiens_hsa052230.48106927
106Intestinal immune network for IgA production_Homo sapiens_hsa046720.45538449
107Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45046428
108Butanoate metabolism_Homo sapiens_hsa006500.44836238
109Cyanoamino acid metabolism_Homo sapiens_hsa004600.44482815
110Leishmaniasis_Homo sapiens_hsa051400.44029139
111Galactose metabolism_Homo sapiens_hsa000520.43661118
112T cell receptor signaling pathway_Homo sapiens_hsa046600.42128487
113Alzheimers disease_Homo sapiens_hsa050100.41677262
114Pathways in cancer_Homo sapiens_hsa052000.41213960
115HIF-1 signaling pathway_Homo sapiens_hsa040660.41069757
116Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41033984
117VEGF signaling pathway_Homo sapiens_hsa043700.40836765
118Melanoma_Homo sapiens_hsa052180.39834004
119Sulfur metabolism_Homo sapiens_hsa009200.37184880
120AMPK signaling pathway_Homo sapiens_hsa041520.36971042
121Influenza A_Homo sapiens_hsa051640.36900066
122Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.36166375
123Neurotrophin signaling pathway_Homo sapiens_hsa047220.35032503
124Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34050460
125Arginine and proline metabolism_Homo sapiens_hsa003300.33140463
126Endometrial cancer_Homo sapiens_hsa052130.32981572
127Wnt signaling pathway_Homo sapiens_hsa043100.32079137
128Prostate cancer_Homo sapiens_hsa052150.31521389
129Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31350347
130Jak-STAT signaling pathway_Homo sapiens_hsa046300.30768242
131Proteoglycans in cancer_Homo sapiens_hsa052050.28570962
132Adherens junction_Homo sapiens_hsa045200.28485086
133Carbon metabolism_Homo sapiens_hsa012000.28122844
134Longevity regulating pathway - mammal_Homo sapiens_hsa042110.27872698
135Phenylalanine metabolism_Homo sapiens_hsa003600.27865912
136Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.26857419
137NOD-like receptor signaling pathway_Homo sapiens_hsa046210.26603492
138Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.25282221
139Peroxisome_Homo sapiens_hsa041460.24666240
140Tight junction_Homo sapiens_hsa045300.24418645
141Toxoplasmosis_Homo sapiens_hsa051450.23493285
142AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.20780502

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