PRMT8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Arginine methylation is a widespread posttranslational modification mediated by arginine methyltransferases, such as PRMT8. Arginine methylation is involved in a number of cellular processes, including DNA repair, RNA transcription, signal transduction, protein compartmentalization, and possibly protein translation (Lee et al., 2005 [PubMed 16051612]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.99951311
2vocalization behavior (GO:0071625)5.74389959
3behavioral response to nicotine (GO:0035095)5.64170981
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.57149876
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.54653052
6synaptic vesicle exocytosis (GO:0016079)5.48323560
7locomotory exploration behavior (GO:0035641)5.42746212
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.39548103
9synaptic vesicle maturation (GO:0016188)5.26451398
10glutamate secretion (GO:0014047)5.17608195
11protein localization to synapse (GO:0035418)5.12578439
12regulation of glutamate receptor signaling pathway (GO:1900449)5.10820478
13ionotropic glutamate receptor signaling pathway (GO:0035235)5.02065068
14synaptic vesicle docking involved in exocytosis (GO:0016081)4.90137805
15regulation of synaptic vesicle exocytosis (GO:2000300)4.88935216
16neuron cell-cell adhesion (GO:0007158)4.79477900
17neuronal action potential propagation (GO:0019227)4.63129892
18glutamate receptor signaling pathway (GO:0007215)4.62587717
19regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.57709707
20exploration behavior (GO:0035640)4.55900831
21regulation of long-term neuronal synaptic plasticity (GO:0048169)4.45373109
22synaptic transmission, glutamatergic (GO:0035249)4.41683681
23neurotransmitter secretion (GO:0007269)4.40430189
24regulation of synaptic vesicle transport (GO:1902803)4.39252384
25neuron-neuron synaptic transmission (GO:0007270)4.32852884
26regulation of neuronal synaptic plasticity (GO:0048168)4.31969997
27neurotransmitter-gated ion channel clustering (GO:0072578)4.29954057
28layer formation in cerebral cortex (GO:0021819)4.09783630
29gamma-aminobutyric acid signaling pathway (GO:0007214)4.06291626
30positive regulation of synapse maturation (GO:0090129)4.05769781
31regulation of excitatory postsynaptic membrane potential (GO:0060079)4.03690934
32regulation of synapse structural plasticity (GO:0051823)4.00578082
33dendritic spine morphogenesis (GO:0060997)3.99775398
34neuron recognition (GO:0008038)3.96942273
35regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.91679700
36regulation of postsynaptic membrane potential (GO:0060078)3.89867658
37negative regulation of synaptic transmission, GABAergic (GO:0032229)3.88042232
38long-term memory (GO:0007616)3.85012328
39gamma-aminobutyric acid transport (GO:0015812)3.82819756
40regulation of dendritic spine morphogenesis (GO:0061001)3.73393891
41pyrimidine nucleobase catabolic process (GO:0006208)3.73296411
42long-term synaptic potentiation (GO:0060291)3.73236236
43regulation of synaptic plasticity (GO:0048167)3.72487645
44positive regulation of membrane potential (GO:0045838)3.71147046
45presynaptic membrane assembly (GO:0097105)3.69730107
46postsynaptic membrane organization (GO:0001941)3.68352135
47membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.66434226
48cellular potassium ion homeostasis (GO:0030007)3.65057339
49axonal fasciculation (GO:0007413)3.64612751
50G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.63476543
51synaptic vesicle endocytosis (GO:0048488)3.60894390
52proline transport (GO:0015824)3.59424777
53response to histamine (GO:0034776)3.57707574
54neurotransmitter transport (GO:0006836)3.56858920
55positive regulation of neurotransmitter secretion (GO:0001956)3.52431408
56regulation of neurotransmitter secretion (GO:0046928)3.49878041
57transmission of nerve impulse (GO:0019226)3.47309429
58regulation of synaptic transmission, glutamatergic (GO:0051966)3.45971735
59presynaptic membrane organization (GO:0097090)3.45159738
60cell differentiation in hindbrain (GO:0021533)3.41688173
61nucleobase catabolic process (GO:0046113)3.40664015
62behavioral fear response (GO:0001662)3.39703880
63behavioral defense response (GO:0002209)3.39703880
64behavioral response to cocaine (GO:0048148)3.36220251
65cerebellar Purkinje cell differentiation (GO:0021702)3.35906217
66cerebellar granule cell differentiation (GO:0021707)3.35087271
67neurofilament cytoskeleton organization (GO:0060052)3.33994021
68regulation of vesicle fusion (GO:0031338)3.32597870
69regulation of neurotransmitter levels (GO:0001505)3.31220473
70epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.30660927
71fear response (GO:0042596)3.29230662
72positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.28393675
73regulation of synapse maturation (GO:0090128)3.27957386
74membrane depolarization (GO:0051899)3.27876829
75positive regulation of dendritic spine morphogenesis (GO:0061003)3.27726842
76L-fucose catabolic process (GO:0042355)3.25120478
77fucose catabolic process (GO:0019317)3.25120478
78L-fucose metabolic process (GO:0042354)3.25120478
79positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.24381635
80positive regulation of neurotransmitter transport (GO:0051590)3.23831812
81regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.22268984
82learning (GO:0007612)3.21853066
83regulation of dendritic spine development (GO:0060998)3.21559198
84regulation of neurotransmitter transport (GO:0051588)3.19455243
85innervation (GO:0060384)3.19379082
86dendritic spine organization (GO:0097061)3.19288529
87regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.18852009
88primary amino compound metabolic process (GO:1901160)3.18344536
89neuromuscular process controlling balance (GO:0050885)3.17298485
90membrane hyperpolarization (GO:0060081)3.16439809
91auditory behavior (GO:0031223)3.15216297
92membrane depolarization during action potential (GO:0086010)3.14832993
93synapse assembly (GO:0007416)3.13752338
94startle response (GO:0001964)3.12385540
95long term synaptic depression (GO:0060292)3.12026247
96negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.11836143
97G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.11607496
98retinal cone cell development (GO:0046549)3.11403567
99neuromuscular synaptic transmission (GO:0007274)3.08943926
100activation of protein kinase A activity (GO:0034199)3.08403935
101synaptic transmission (GO:0007268)3.06928322
102regulation of synaptic transmission (GO:0050804)3.06403103
103response to amphetamine (GO:0001975)3.06355793
104positive regulation of dendritic spine development (GO:0060999)3.06161863
105regulation of glutamate secretion (GO:0014048)3.06106438
106cell migration in hindbrain (GO:0021535)3.05231714
107serotonin metabolic process (GO:0042428)3.03102513
108dendrite morphogenesis (GO:0048813)3.03101879
109positive regulation of synaptic transmission, GABAergic (GO:0032230)3.02578735
110short-term memory (GO:0007614)3.02076438
111positive regulation of synaptic transmission (GO:0050806)3.01150759
112intraspecies interaction between organisms (GO:0051703)3.00701884
113social behavior (GO:0035176)3.00701884
114synaptic transmission, cholinergic (GO:0007271)2.99421420
115DNA deamination (GO:0045006)2.98378429
116central nervous system projection neuron axonogenesis (GO:0021952)2.97859541
117regulation of voltage-gated calcium channel activity (GO:1901385)2.97757689
118response to auditory stimulus (GO:0010996)2.97006804
119axon ensheathment in central nervous system (GO:0032291)2.93999154
120central nervous system myelination (GO:0022010)2.93999154
121cerebellum development (GO:0021549)2.92543992
122prepulse inhibition (GO:0060134)2.90592041
123neuronal ion channel clustering (GO:0045161)2.89576020
124spinal cord association neuron differentiation (GO:0021527)2.86320514
125chemosensory behavior (GO:0007635)2.84634136
126epithelial cilium movement (GO:0003351)2.82369242
127adult walking behavior (GO:0007628)2.74661352
128parturition (GO:0007567)2.71173805
129cytidine deamination (GO:0009972)2.70771227
130cytidine metabolic process (GO:0046087)2.70771227
131cytidine catabolic process (GO:0006216)2.70771227
132positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.69454182
133negative regulation of cytosolic calcium ion concentration (GO:0051481)2.66719688
134neuronal action potential (GO:0019228)2.65780630
135calcium ion-dependent exocytosis (GO:0017156)2.65713948
136behavioral response to ethanol (GO:0048149)2.64740518
137C4-dicarboxylate transport (GO:0015740)2.63146031
138adult behavior (GO:0030534)2.60003710

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.43055992
2GBX2_23144817_ChIP-Seq_PC3_Human3.86028739
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.24229642
4* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.19831477
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.11742851
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.79373109
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.78072344
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.78072344
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.72944452
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.71361144
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.63224722
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.60792075
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.53937699
14* RARB_27405468_Chip-Seq_BRAIN_Mouse2.52750756
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.48856664
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.46817702
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.37817369
18* EZH2_27294783_Chip-Seq_ESCs_Mouse2.27712554
19* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.27545663
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.27378839
21DROSHA_22980978_ChIP-Seq_HELA_Human2.23690255
22* REST_18959480_ChIP-ChIP_MESCs_Mouse2.19945825
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.09530141
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.07560704
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.04544667
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.99396489
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.98912963
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.95314516
29TAF15_26573619_Chip-Seq_HEK293_Human1.90514700
30* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.83315014
31AR_21572438_ChIP-Seq_LNCaP_Human1.81683917
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.74442866
33* SMAD4_21799915_ChIP-Seq_A2780_Human1.71739398
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.70847173
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.68666088
36ERG_21242973_ChIP-ChIP_JURKAT_Human1.60825952
37EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59020475
38P300_19829295_ChIP-Seq_ESCs_Human1.58873294
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58289004
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.52717838
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.50730687
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.49551480
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.47516847
44ZNF274_21170338_ChIP-Seq_K562_Hela1.41633918
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40990046
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.40020063
47* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35896112
48RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35864121
49RING1B_27294783_Chip-Seq_ESCs_Mouse1.35474638
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33797230
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33727173
52* AR_25329375_ChIP-Seq_VCAP_Human1.32581959
53* SOX2_21211035_ChIP-Seq_LN229_Gbm1.30939497
54RNF2_27304074_Chip-Seq_NSC_Mouse1.29321510
55NR3C1_23031785_ChIP-Seq_PC12_Mouse1.29151671
56PCGF2_27294783_Chip-Seq_ESCs_Mouse1.28201445
57SMAD_19615063_ChIP-ChIP_OVARY_Human1.27462756
58FUS_26573619_Chip-Seq_HEK293_Human1.26099134
59OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25596037
60POU3F2_20337985_ChIP-ChIP_501MEL_Human1.25235433
61FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.24755283
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.24217030
63* STAT3_23295773_ChIP-Seq_U87_Human1.23004819
64* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.22788215
65* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.22020779
66IGF1R_20145208_ChIP-Seq_DFB_Human1.20999306
67TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18855561
68AR_19668381_ChIP-Seq_PC3_Human1.18777784
69RING1B_27294783_Chip-Seq_NPCs_Mouse1.18691258
70SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17161018
71VDR_22108803_ChIP-Seq_LS180_Human1.16738300
72MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16357020
73P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14271947
74ETV2_25802403_ChIP-Seq_MESCs_Mouse1.14201729
75ER_23166858_ChIP-Seq_MCF-7_Human1.13800982
76TP53_22573176_ChIP-Seq_HFKS_Human1.12486470
77TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.10504145
78ARNT_22903824_ChIP-Seq_MCF-7_Human1.10452693
79TCF4_23295773_ChIP-Seq_U87_Human1.10323771
80IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.09672859
81CBP_20019798_ChIP-Seq_JUKART_Human1.09672859
82EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06965818
83MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06533996
84YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06491758
85UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05419321
86ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05306971
87WT1_25993318_ChIP-Seq_PODOCYTE_Human1.04799620
88AHR_22903824_ChIP-Seq_MCF-7_Human1.04487894
89RUNX2_22187159_ChIP-Seq_PCA_Human1.04467511
90* PRDM14_20953172_ChIP-Seq_ESCs_Human1.03302514
91DNAJC2_21179169_ChIP-ChIP_NT2_Human1.03186083
92CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.02978715
93TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02657859
94POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02657859
95EWS_26573619_Chip-Seq_HEK293_Human1.02461546
96RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02369342
97CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01826219
98AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01172388
99FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.00666822
100NCOR_22424771_ChIP-Seq_293T_Human1.00184221
101MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00131484
102ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.99455148
103NANOG_19829295_ChIP-Seq_ESCs_Human0.97972210
104SOX2_19829295_ChIP-Seq_ESCs_Human0.97972210
105TCF4_22108803_ChIP-Seq_LS180_Human0.97908360
106NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97757701
107* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97387876
108JUN_21703547_ChIP-Seq_K562_Human0.97019535
109PCGF2_27294783_Chip-Seq_NPCs_Mouse0.96518355
110SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94171294
111HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.93823884
112TP53_16413492_ChIP-PET_HCT116_Human0.93527576
113NFE2_27457419_Chip-Seq_LIVER_Mouse0.93525832
114TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93350890
115CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93200111
116* SMAD3_21741376_ChIP-Seq_ESCs_Human0.93007935
117WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.92053499
118* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.90709979
119BCAT_22108803_ChIP-Seq_LS180_Human0.90642529
120IRF1_19129219_ChIP-ChIP_H3396_Human0.90510759
121CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.90467343
122NANOG_18555785_Chip-Seq_ESCs_Mouse0.90395222
123SMAD3_21741376_ChIP-Seq_HESCs_Human0.88804940
124TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88298694
125TP53_18474530_ChIP-ChIP_U2OS_Human0.88068324
126* SMAD4_21741376_ChIP-Seq_HESCs_Human0.87498954
127RXR_22108803_ChIP-Seq_LS180_Human0.87171319
128PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.86793779

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.37602092
2MP0003880_abnormal_central_pattern5.04197030
3MP0003635_abnormal_synaptic_transmissio4.17619689
4MP0004270_analgesia3.71551341
5MP0009745_abnormal_behavioral_response3.51046706
6MP0002063_abnormal_learning/memory/cond3.44918509
7MP0001968_abnormal_touch/_nociception3.18087086
8MP0002064_seizures3.13689669
9MP0009046_muscle_twitch3.11747521
10MP0002572_abnormal_emotion/affect_behav2.94269267
11MP0002272_abnormal_nervous_system2.68284639
12MP0002734_abnormal_mechanical_nocicepti2.65340780
13MP0005423_abnormal_somatic_nervous2.63351273
14MP0001486_abnormal_startle_reflex2.58024482
15MP0002736_abnormal_nociception_after2.57645959
16MP0001501_abnormal_sleep_pattern2.51674368
17MP0002735_abnormal_chemical_nociception2.47806841
18MP0002822_catalepsy2.31156911
19MP0001440_abnormal_grooming_behavior2.27298087
20MP0002733_abnormal_thermal_nociception2.11349986
21MP0002067_abnormal_sensory_capabilities2.07196581
22MP0006276_abnormal_autonomic_nervous2.05090495
23MP0000778_abnormal_nervous_system2.03174422
24MP0002184_abnormal_innervation2.02455940
25MP0001970_abnormal_pain_threshold1.95461334
26MP0002557_abnormal_social/conspecific_i1.87717591
27MP0001986_abnormal_taste_sensitivity1.85297844
28MP0004924_abnormal_behavior1.80558120
29MP0005386_behavior/neurological_phenoty1.80558120
30MP0008569_lethality_at_weaning1.75486197
31MP0004811_abnormal_neuron_physiology1.73028741
32MP0002102_abnormal_ear_morphology1.72313052
33MP0008877_abnormal_DNA_methylation1.72024035
34MP0001984_abnormal_olfaction1.71010439
35MP0009780_abnormal_chondrocyte_physiolo1.71000045
36MP0003329_amyloid_beta_deposits1.65704700
37MP0003879_abnormal_hair_cell1.61572821
38MP0005646_abnormal_pituitary_gland1.56914230
39MP0003787_abnormal_imprinting1.55939956
40MP0001188_hyperpigmentation1.55282558
41MP0002909_abnormal_adrenal_gland1.55206603
42MP0000955_abnormal_spinal_cord1.55032788
43MP0004858_abnormal_nervous_system1.48658376
44MP0002882_abnormal_neuron_morphology1.46231395
45MP0001529_abnormal_vocalization1.43961110
46MP0002066_abnormal_motor_capabilities/c1.42821632
47MP0001502_abnormal_circadian_rhythm1.38263292
48MP0004142_abnormal_muscle_tone1.29560692
49MP0005645_abnormal_hypothalamus_physiol1.27531627
50MP0001905_abnormal_dopamine_level1.26385789
51MP0004885_abnormal_endolymph1.26107141
52MP0003136_yellow_coat_color1.26072966
53MP0009379_abnormal_foot_pigmentation1.18778166
54MP0005253_abnormal_eye_physiology1.15341577
55MP0002152_abnormal_brain_morphology1.15119164
56MP0003633_abnormal_nervous_system1.14275463
57MP0005551_abnormal_eye_electrophysiolog1.12021061
58MP0008875_abnormal_xenobiotic_pharmacok1.10529962
59MP0003121_genomic_imprinting1.08013593
60MP0003122_maternal_imprinting1.06278452
61MP0004145_abnormal_muscle_electrophysio1.05687105
62MP0003011_delayed_dark_adaptation1.05394136
63MP0004742_abnormal_vestibular_system1.04681306
64MP0002163_abnormal_gland_morphology1.02737928
65MP0003938_abnormal_ear_development1.02270478
66MP0003631_nervous_system_phenotype1.01316966
67MP0010386_abnormal_urinary_bladder0.98617063
68MP0008872_abnormal_physiological_respon0.95003093
69MP0002069_abnormal_eating/drinking_beha0.94601848
70MP0005394_taste/olfaction_phenotype0.93701119
71MP0005499_abnormal_olfactory_system0.93701119
72MP0002229_neurodegeneration0.92747284
73MP0002928_abnormal_bile_duct0.92281288
74MP0000751_myopathy0.92258630
75MP0004085_abnormal_heartbeat0.90392448
76MP0002837_dystrophic_cardiac_calcinosis0.88602178
77MP0001963_abnormal_hearing_physiology0.88425809
78MP0002752_abnormal_somatic_nervous0.86506661
79MP0000631_abnormal_neuroendocrine_gland0.85597441
80MP0000538_abnormal_urinary_bladder0.84032444
81MP0001177_atelectasis0.83828952
82MP0000569_abnormal_digit_pigmentation0.82386750
83MP0008874_decreased_physiological_sensi0.81285990
84MP0005535_abnormal_body_temperature0.81098660
85MP0008789_abnormal_olfactory_epithelium0.77995085
86MP0004043_abnormal_pH_regulation0.77633682
87MP0003123_paternal_imprinting0.77551778
88MP0002160_abnormal_reproductive_system0.76735391
89MP0002138_abnormal_hepatobiliary_system0.76584221
90MP0004147_increased_porphyrin_level0.76186473
91MP0002876_abnormal_thyroid_physiology0.74725832
92MP0003632_abnormal_nervous_system0.73787467
93MP0004215_abnormal_myocardial_fiber0.73663143
94MP0004484_altered_response_of0.73348375
95MP0002638_abnormal_pupillary_reflex0.72812697
96MP0003890_abnormal_embryonic-extraembry0.71693198
97MP0005187_abnormal_penis_morphology0.71225555
98MP0005195_abnormal_posterior_eye0.71168703
99MP0005389_reproductive_system_phenotype0.69813483
100MP0005409_darkened_coat_color0.69685373
101MP0003634_abnormal_glial_cell0.69658600
102MP0005379_endocrine/exocrine_gland_phen0.69424656
103MP0004233_abnormal_muscle_weight0.67304881
104MP0000013_abnormal_adipose_tissue0.66623911
105MP0003861_abnormal_nervous_system0.66013421
106MP0001485_abnormal_pinna_reflex0.65674878
107MP0001664_abnormal_digestion0.65390534
108MP0000604_amyloidosis0.63149871
109MP0004133_heterotaxia0.63017242
110MP0005410_abnormal_fertilization0.62722889
111MP0003137_abnormal_impulse_conducting0.62310276
112MP0000427_abnormal_hair_cycle0.61689633
113MP0006292_abnormal_olfactory_placode0.60616876
114MP0005084_abnormal_gallbladder_morpholo0.60042767
115MP0001943_abnormal_respiration0.60020134
116MP0000026_abnormal_inner_ear0.59295579
117MP0008961_abnormal_basal_metabolism0.58338997
118MP0002090_abnormal_vision0.58199350
119MP0003075_altered_response_to0.58058864
120MP0010769_abnormal_survival0.54090708
121MP0002082_postnatal_lethality0.53564983
122MP0010770_preweaning_lethality0.53564983
123MP0002653_abnormal_ependyma_morphology0.52413470
124MP0010768_mortality/aging0.51530731
125MP0002751_abnormal_autonomic_nervous0.50701224
126MP0006072_abnormal_retinal_apoptosis0.50370324
127MP0003956_abnormal_body_size0.48696988

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.34399111
2Myokymia (HP:0002411)6.44595248
3Focal seizures (HP:0007359)6.02324453
4Epileptic encephalopathy (HP:0200134)5.66247136
5Visual hallucinations (HP:0002367)5.27557579
6Atonic seizures (HP:0010819)5.04303597
7Febrile seizures (HP:0002373)5.02380025
8Absence seizures (HP:0002121)4.67066961
9Hyperventilation (HP:0002883)4.39420512
10Progressive cerebellar ataxia (HP:0002073)4.39403487
11Dialeptic seizures (HP:0011146)4.26482887
12Broad-based gait (HP:0002136)4.03623893
13Generalized tonic-clonic seizures (HP:0002069)4.01573048
14Poor eye contact (HP:0000817)3.63014177
15Action tremor (HP:0002345)3.56681636
16Amblyopia (HP:0000646)3.53774634
17Gaze-evoked nystagmus (HP:0000640)3.44896024
18Supranuclear gaze palsy (HP:0000605)3.26437494
19Dysdiadochokinesis (HP:0002075)3.18784224
20Abnormal social behavior (HP:0012433)3.18782743
21Impaired social interactions (HP:0000735)3.18782743
22Impaired vibration sensation in the lower limbs (HP:0002166)3.07695038
23Drooling (HP:0002307)3.07302193
24Excessive salivation (HP:0003781)3.07302193
25Truncal ataxia (HP:0002078)3.07266189
26Congenital stationary night blindness (HP:0007642)3.06606765
27Anxiety (HP:0000739)2.92789979
28Abnormal pancreas size (HP:0012094)2.92754964
29Molar tooth sign on MRI (HP:0002419)2.92602184
30Abnormality of midbrain morphology (HP:0002418)2.92602184
31Depression (HP:0000716)2.92164858
32Pancreatic cysts (HP:0001737)2.91972444
33Epileptiform EEG discharges (HP:0011182)2.86855861
34Dysmetria (HP:0001310)2.86418947
35Mutism (HP:0002300)2.79326294
36Chronic hepatic failure (HP:0100626)2.73912722
37Nephronophthisis (HP:0000090)2.73774220
38Abnormal rod and cone electroretinograms (HP:0008323)2.73558353
39Absent rod-and cone-mediated responses on ERG (HP:0007688)2.72991606
40Pancreatic fibrosis (HP:0100732)2.72712797
41Absent speech (HP:0001344)2.71412210
42Urinary bladder sphincter dysfunction (HP:0002839)2.70832292
43Ankle clonus (HP:0011448)2.68914209
44Hemiparesis (HP:0001269)2.68736063
45Impaired smooth pursuit (HP:0007772)2.67918439
46Abnormal eating behavior (HP:0100738)2.67684277
47Abnormality of the lower motor neuron (HP:0002366)2.66963334
48Medial flaring of the eyebrow (HP:0010747)2.65103888
49EEG with generalized epileptiform discharges (HP:0011198)2.64339749
50Diplopia (HP:0000651)2.63630383
51Abnormality of binocular vision (HP:0011514)2.63630383
52Type II lissencephaly (HP:0007260)2.62501201
53Genetic anticipation (HP:0003743)2.61872221
54Cerebral inclusion bodies (HP:0100314)2.58404905
55Inability to walk (HP:0002540)2.57307670
56Stereotypic behavior (HP:0000733)2.55946625
57Scanning speech (HP:0002168)2.54708879
58Abnormal drinking behavior (HP:0030082)2.52671362
59Polydipsia (HP:0001959)2.52671362
60Fetal akinesia sequence (HP:0001989)2.51443382
61True hermaphroditism (HP:0010459)2.47276756
62Progressive inability to walk (HP:0002505)2.44559892
63Protruding tongue (HP:0010808)2.44484703
64Hypsarrhythmia (HP:0002521)2.44291377
65Urinary urgency (HP:0000012)2.43432820
66Postural instability (HP:0002172)2.40419874
67Abnormal respiratory motile cilium morphology (HP:0005938)2.39332154
68Abnormal respiratory epithelium morphology (HP:0012253)2.39332154
69Dysmetric saccades (HP:0000641)2.33684652
70Abnormality of the renal medulla (HP:0100957)2.33569600
71Neurofibrillary tangles (HP:0002185)2.32251305
72Limb dystonia (HP:0002451)2.31859986
73Thyroid-stimulating hormone excess (HP:0002925)2.31026143
74Acute necrotizing encephalopathy (HP:0006965)2.31000828
75Optic nerve hypoplasia (HP:0000609)2.29886076
76Status epilepticus (HP:0002133)2.29832715
77Abnormality of ocular smooth pursuit (HP:0000617)2.29241710
78Torticollis (HP:0000473)2.29235904
79Insidious onset (HP:0003587)2.26593680
80Termporal pattern (HP:0011008)2.26593680
81Decreased circulating renin level (HP:0003351)2.26422177
82Mitochondrial inheritance (HP:0001427)2.24084212
83Spastic gait (HP:0002064)2.23232608
84Bradykinesia (HP:0002067)2.22920865
85Abnormality of the corticospinal tract (HP:0002492)2.22545699
86Generalized myoclonic seizures (HP:0002123)2.22238168
87Progressive macrocephaly (HP:0004481)2.22236020
88Focal dystonia (HP:0004373)2.20707246
89Absent/shortened dynein arms (HP:0200106)2.19860259
90Dynein arm defect of respiratory motile cilia (HP:0012255)2.19860259
91Papilledema (HP:0001085)2.17112872
92Abolished electroretinogram (ERG) (HP:0000550)2.11808000
93Hemiplegia (HP:0002301)2.09990693
94Cystic liver disease (HP:0006706)2.08075810
95Amyotrophic lateral sclerosis (HP:0007354)2.08069792
96Incomplete penetrance (HP:0003829)2.08046442
97Abnormality of the renal cortex (HP:0011035)2.07778481
98Retinal dysplasia (HP:0007973)2.07658611
99Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.06001446
100Polyuria (HP:0000103)2.05529719
101Impaired vibratory sensation (HP:0002495)2.05344432
102Decreased central vision (HP:0007663)2.04780799
103Inappropriate behavior (HP:0000719)2.03055334
104Abnormality of salivation (HP:0100755)2.02999210
105Blue irides (HP:0000635)2.02784398
106Polyphagia (HP:0002591)2.01301718
107Congenital primary aphakia (HP:0007707)2.00954582
108Annular pancreas (HP:0001734)2.00897486
109Abnormal ciliary motility (HP:0012262)1.98900610
110Gait imbalance (HP:0002141)1.98063838
111Delusions (HP:0000746)1.97781619
112Intention tremor (HP:0002080)1.97494485
113Gait ataxia (HP:0002066)1.97414047
114Metabolic alkalosis (HP:0200114)1.97292720
115Megalencephaly (HP:0001355)1.96846530
116Optic disc pallor (HP:0000543)1.93882499
117Increased CSF lactate (HP:0002490)1.93426091
118Attenuation of retinal blood vessels (HP:0007843)1.92895177
119Pheochromocytoma (HP:0002666)1.92807587
120Abnormal mitochondria in muscle tissue (HP:0008316)1.92608472
121Craniofacial dystonia (HP:0012179)1.91592233
122Abnormal respiratory motile cilium physiology (HP:0012261)1.91246618
123Nephrogenic diabetes insipidus (HP:0009806)1.89908129
124Lower limb muscle weakness (HP:0007340)1.89619541
125Pachygyria (HP:0001302)1.86141917
126Specific learning disability (HP:0001328)1.85180394
127Lower limb asymmetry (HP:0100559)1.84353999
128Vaginal atresia (HP:0000148)1.81746697
129Lissencephaly (HP:0001339)1.80789174
130Dyskinesia (HP:0100660)1.80781804
131Agitation (HP:0000713)1.80113767
132Hypothermia (HP:0002045)1.80056960
133Genital tract atresia (HP:0001827)1.79550187
134Cerebral hypomyelination (HP:0006808)1.78847184
135Obstructive sleep apnea (HP:0002870)1.78340370
136Pointed chin (HP:0000307)1.78148680
137Hypoplasia of the brainstem (HP:0002365)1.77330199
138Aplasia/Hypoplasia of the brainstem (HP:0007362)1.77330199
139Tubular atrophy (HP:0000092)1.77245970
140Spastic tetraplegia (HP:0002510)1.76034618
141Bony spicule pigmentary retinopathy (HP:0007737)1.75767994
142Sclerocornea (HP:0000647)1.75737404
143Acute encephalopathy (HP:0006846)1.75633784
144Widely spaced teeth (HP:0000687)1.75427315
145Hyperthyroidism (HP:0000836)1.75409400
146Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.75053754
147Psychosis (HP:0000709)1.74713793
148Oligodactyly (hands) (HP:0001180)1.74563397
149Hepatocellular necrosis (HP:0001404)1.74448312
150Autism (HP:0000717)1.72585479
151Akinesia (HP:0002304)1.72496585
152Generalized hypopigmentation of hair (HP:0011358)1.71682992
153Exotropia (HP:0000577)1.70938229
154Ventricular fibrillation (HP:0001663)1.70736336
155Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.70331218
156Neuroendocrine neoplasm (HP:0100634)1.66584963
157Aqueductal stenosis (HP:0002410)1.64560463

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.60769406
2EPHA44.53856879
3MAP3K93.59901763
4FRK3.59891979
5MARK13.14569133
6MAP3K43.07656952
7DAPK22.75040554
8MINK12.74753890
9MAP2K72.74689015
10RIPK42.64990701
11CASK2.59829932
12ADRBK22.59256761
13MAP3K122.19051549
14PAK62.05454412
15MAP2K42.01656193
16WNK41.99994187
17TXK1.92590039
18DAPK11.89959160
19KSR11.88783026
20KSR21.88606467
21NTRK21.87544696
22PLK21.85943914
23PNCK1.80555798
24SIK21.68191814
25BMPR1B1.59398848
26CDK191.51730878
27GRK11.45918020
28CDK51.45777284
29TNIK1.45469295
30CAMKK11.45317027
31GRK51.43390661
32MAPK131.42310100
33PRPF4B1.42093116
34MAP4K21.42004776
35NTRK11.34252840
36TLK11.32968288
37ARAF1.24930512
38PRKCG1.24397586
39BMPR21.24173467
40PRKD31.15941942
41DYRK21.15595638
42MAP3K131.15452188
43FES1.11195098
44CAMK2A1.10803025
45SIK31.09707302
46CAMKK21.08139862
47STK381.06489963
48INSRR1.05515117
49CCNB11.05171804
50PTK2B1.01588680
51UHMK11.01229722
52BCKDK0.95510969
53TYRO30.94819296
54MAP3K20.89133707
55CAMK2B0.88499841
56CDK180.88101705
57ZAK0.87069757
58CDK140.85684985
59TRIM280.83357145
60CDK150.83105624
61CAMK10.82779440
62LATS20.81777203
63SGK2230.81607984
64SGK4940.81607984
65CSNK1G30.80981900
66DYRK1A0.79109840
67RAF10.77253115
68NME10.77017339
69STK390.75876197
70SGK20.75709206
71PHKG10.74360800
72PHKG20.74360800
73STK110.73857728
74CSNK1G20.72978198
75CDK11A0.72317333
76OXSR10.71516824
77SGK10.68567267
78CSNK1G10.67076226
79PRKCQ0.66590822
80NUAK10.65448574
81ITK0.65292123
82MAPKAPK50.65070963
83PINK10.65009703
84AKT30.64309322
85FGR0.64062718
86RET0.63646528
87PAK30.61824050
88MAP3K60.60644200
89MARK20.60304696
90PRKCI0.60142104
91CSNK1A1L0.59448576
92PRKCE0.57070462
93PRKCA0.55823642
94ERBB20.55143953
95CSNK1A10.54443864
96PRKCZ0.53015148
97PKN10.52380793
98TAOK10.51310289
99WNK30.50597978
100BCR0.50306604
101ACVR1B0.48768706
102SGK30.48461282
103TNK20.48076728
104WNK10.47272503
105MAPK120.46366133
106EPHB20.46292248
107ERBB30.45615948
108PRKCH0.45433575
109CAMK2D0.45169546
110FER0.45002237
111PIK3CA0.44896603
112MAP2K10.44583228
113LIMK10.44457403
114PDK10.43810852
115MAP2K60.43207224
116DAPK30.41294719
117RPS6KA30.41034282
118PDPK10.40643460
119CAMK2G0.40216878
120CAMK1G0.39808205
121FGFR20.39445527
122FYN0.39213489
123MAP2K20.39124731
124PRKG10.38637640
125CAMK40.38551262
126BRAF0.38242681
127ALK0.37610536
128MAP3K10.37274328
129SYK0.36875152
130CSNK1D0.36143009
131GRK70.34631724
132CHUK0.34173510
133MAPK100.33362231
134PRKACA0.30628418
135ADRBK10.30574144
136PRKCB0.29394839
137MUSK0.29198950
138NEK60.28536257

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.13735823
2Synaptic vesicle cycle_Homo sapiens_hsa047213.34393519
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.90047265
4Long-term potentiation_Homo sapiens_hsa047202.86498535
5Circadian entrainment_Homo sapiens_hsa047132.75860842
6GABAergic synapse_Homo sapiens_hsa047272.75359459
7Glutamatergic synapse_Homo sapiens_hsa047242.66696599
8Olfactory transduction_Homo sapiens_hsa047402.62530841
9Amphetamine addiction_Homo sapiens_hsa050312.62322675
10Morphine addiction_Homo sapiens_hsa050322.59239548
11Dopaminergic synapse_Homo sapiens_hsa047282.26972509
12Salivary secretion_Homo sapiens_hsa049702.20501809
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.08361075
14Taste transduction_Homo sapiens_hsa047422.01896932
15Insulin secretion_Homo sapiens_hsa049111.93605033
16Serotonergic synapse_Homo sapiens_hsa047261.90924393
17Nitrogen metabolism_Homo sapiens_hsa009101.88849101
18Long-term depression_Homo sapiens_hsa047301.88363493
19Cholinergic synapse_Homo sapiens_hsa047251.87289484
20Renin secretion_Homo sapiens_hsa049241.82001859
21Gastric acid secretion_Homo sapiens_hsa049711.79210433
22Collecting duct acid secretion_Homo sapiens_hsa049661.76290455
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.75104413
24Oxytocin signaling pathway_Homo sapiens_hsa049211.71249533
25Cocaine addiction_Homo sapiens_hsa050301.64414706
26Calcium signaling pathway_Homo sapiens_hsa040201.63039005
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.59815688
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.45253708
29GnRH signaling pathway_Homo sapiens_hsa049121.44464476
30Gap junction_Homo sapiens_hsa045401.37656392
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.33592190
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.33425054
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.29346724
34Linoleic acid metabolism_Homo sapiens_hsa005911.27192519
35Axon guidance_Homo sapiens_hsa043601.24593116
36Phototransduction_Homo sapiens_hsa047441.22883552
37cAMP signaling pathway_Homo sapiens_hsa040241.22442779
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.16408826
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.16086078
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.13264789
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.11150492
42Cardiac muscle contraction_Homo sapiens_hsa042601.10891166
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.09967156
44Glioma_Homo sapiens_hsa052141.09203568
45Estrogen signaling pathway_Homo sapiens_hsa049151.07295185
46cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06230917
47Type II diabetes mellitus_Homo sapiens_hsa049301.05806993
48Melanogenesis_Homo sapiens_hsa049161.04674157
49ErbB signaling pathway_Homo sapiens_hsa040121.02937205
50Butanoate metabolism_Homo sapiens_hsa006501.02827635
51Vibrio cholerae infection_Homo sapiens_hsa051101.02539493
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.97571730
53Maturity onset diabetes of the young_Homo sapiens_hsa049500.93158546
54Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.92724786
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.92351780
56Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.91722015
57Oocyte meiosis_Homo sapiens_hsa041140.90190726
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.89447106
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84640190
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82601125
61Ether lipid metabolism_Homo sapiens_hsa005650.79118131
62Pancreatic secretion_Homo sapiens_hsa049720.77971638
63Choline metabolism in cancer_Homo sapiens_hsa052310.74106080
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.73326701
65Alzheimers disease_Homo sapiens_hsa050100.70520758
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.70221944
67MAPK signaling pathway_Homo sapiens_hsa040100.70098898
68Dorso-ventral axis formation_Homo sapiens_hsa043200.68854041
69Regulation of autophagy_Homo sapiens_hsa041400.68702390
70VEGF signaling pathway_Homo sapiens_hsa043700.68019567
71Thyroid hormone synthesis_Homo sapiens_hsa049180.67768747
72Circadian rhythm_Homo sapiens_hsa047100.67019145
73Protein export_Homo sapiens_hsa030600.65452366
74Peroxisome_Homo sapiens_hsa041460.64313866
75Dilated cardiomyopathy_Homo sapiens_hsa054140.62037622
76Caffeine metabolism_Homo sapiens_hsa002320.61027924
77Oxidative phosphorylation_Homo sapiens_hsa001900.59306461
78Ras signaling pathway_Homo sapiens_hsa040140.58089344
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56534081
80Glucagon signaling pathway_Homo sapiens_hsa049220.55094884
81Neurotrophin signaling pathway_Homo sapiens_hsa047220.54571017
82Alcoholism_Homo sapiens_hsa050340.53306310
83Rap1 signaling pathway_Homo sapiens_hsa040150.52160705
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50479300
85Wnt signaling pathway_Homo sapiens_hsa043100.50174658
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49669948
87Mineral absorption_Homo sapiens_hsa049780.48004055
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.47784520
89African trypanosomiasis_Homo sapiens_hsa051430.47510926
90Type I diabetes mellitus_Homo sapiens_hsa049400.47088975
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46681895
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46678001
93Inositol phosphate metabolism_Homo sapiens_hsa005620.46610260
94Intestinal immune network for IgA production_Homo sapiens_hsa046720.44945391
95mTOR signaling pathway_Homo sapiens_hsa041500.44541613
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43453441
97Autoimmune thyroid disease_Homo sapiens_hsa053200.42814307
98Basal transcription factors_Homo sapiens_hsa030220.41947351
99Graft-versus-host disease_Homo sapiens_hsa053320.40586431
100Non-small cell lung cancer_Homo sapiens_hsa052230.38794605
101Parkinsons disease_Homo sapiens_hsa050120.38502578
102Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37767043
103Asthma_Homo sapiens_hsa053100.37694835
104Renal cell carcinoma_Homo sapiens_hsa052110.37659785
105Endometrial cancer_Homo sapiens_hsa052130.37555954
106Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35679337
107RNA polymerase_Homo sapiens_hsa030200.35437013
108Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35135983
109Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34782894
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.32300062
111Retinol metabolism_Homo sapiens_hsa008300.31774890
112Primary bile acid biosynthesis_Homo sapiens_hsa001200.31296567
113Insulin signaling pathway_Homo sapiens_hsa049100.30724015
114Prion diseases_Homo sapiens_hsa050200.29985377
115ABC transporters_Homo sapiens_hsa020100.29727634
116Endocytosis_Homo sapiens_hsa041440.29359844
117Allograft rejection_Homo sapiens_hsa053300.28765331
118Bile secretion_Homo sapiens_hsa049760.27973657
119Arachidonic acid metabolism_Homo sapiens_hsa005900.27953327
120Huntingtons disease_Homo sapiens_hsa050160.27820812
121Primary immunodeficiency_Homo sapiens_hsa053400.27319908
122Colorectal cancer_Homo sapiens_hsa052100.26699925
123Tryptophan metabolism_Homo sapiens_hsa003800.26326219
124Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.26197371
125SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26155002
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.25538288
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.24848875
128Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.24644419
129Rheumatoid arthritis_Homo sapiens_hsa053230.23276444
130Hedgehog signaling pathway_Homo sapiens_hsa043400.23240475
131Ovarian steroidogenesis_Homo sapiens_hsa049130.22513773
132Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.22459095

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