PRMT9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a type II methyltransferase. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to the guanidino nitrogen atoms of arginine. The protein encoded by this gene methylates spliceosome associated protein 145 to regulate alternative splicing and acts as a modulator of small nuclear ribonucleoprotein maturation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1daunorubicin metabolic process (GO:0044597)7.56580431
2polyketide metabolic process (GO:0030638)7.56580431
3doxorubicin metabolic process (GO:0044598)7.56580431
4response to pheromone (GO:0019236)6.55819409
5ribonucleoprotein complex disassembly (GO:0032988)5.18641852
6organelle disassembly (GO:1903008)5.13124134
7tachykinin receptor signaling pathway (GO:0007217)4.83911097
8piRNA metabolic process (GO:0034587)4.66070716
9negative regulation of DNA-dependent DNA replication (GO:2000104)4.41628516
10positive regulation of action potential (GO:0045760)4.41549607
11negative regulation of heart rate (GO:0010459)4.38020377
12aminoglycoside antibiotic metabolic process (GO:0030647)4.33496722
13negative regulation of dendrite morphogenesis (GO:0050774)4.30757567
14DNA damage response, detection of DNA damage (GO:0042769)4.23006315
15nuclear pore complex assembly (GO:0051292)4.22839615
16detection of molecule of bacterial origin (GO:0032490)4.11171793
17purine deoxyribonucleotide catabolic process (GO:0009155)4.10863810
18DNA strand renaturation (GO:0000733)4.05718740
19regulation of nuclear cell cycle DNA replication (GO:0033262)4.01279567
20regulation of centriole replication (GO:0046599)3.90805128
21regulation of meiosis I (GO:0060631)3.89404094
22energy homeostasis (GO:0097009)3.85315409
23regulation of glucocorticoid secretion (GO:2000849)3.83338710
24male meiosis (GO:0007140)3.82910130
25ncRNA catabolic process (GO:0034661)3.81881231
26purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.79759166
27regulation of DNA endoreduplication (GO:0032875)3.77131986
28mitotic metaphase plate congression (GO:0007080)3.76695676
29regulation of mitotic spindle checkpoint (GO:1903504)3.76661379
30regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.76661379
31male meiosis I (GO:0007141)3.75803154
32tRNA methylation (GO:0030488)3.70117742
33positive regulation of mitotic sister chromatid separation (GO:1901970)3.62776095
34positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.62776095
35positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.62776095
36G-protein coupled receptor internalization (GO:0002031)3.56574538
37histone H3-K4 trimethylation (GO:0080182)3.45256034
38chromosome organization involved in meiosis (GO:0070192)3.41356415
39seminiferous tubule development (GO:0072520)3.41251135
40telomere maintenance via telomerase (GO:0007004)3.39862527
41histone exchange (GO:0043486)3.38494395
42superoxide anion generation (GO:0042554)3.37730368
43replicative senescence (GO:0090399)3.37074934
44DNA double-strand break processing (GO:0000729)3.33759737
45peptidyl-lysine trimethylation (GO:0018023)3.33252689
46microtubule depolymerization (GO:0007019)3.32753187
47nucleoside diphosphate catabolic process (GO:0009134)3.31152618
48positive regulation of steroid hormone secretion (GO:2000833)3.30618652
49microtubule severing (GO:0051013)3.30429732
50prenylation (GO:0097354)3.29066580
51protein prenylation (GO:0018342)3.29066580
52protein polyglutamylation (GO:0018095)3.28430653
53mitotic sister chromatid cohesion (GO:0007064)3.26253063
54mesenchymal cell differentiation involved in kidney development (GO:0072161)3.20773841
55mesenchymal cell differentiation involved in renal system development (GO:2001012)3.20773841
56somatic diversification of immune receptors via somatic mutation (GO:0002566)3.18166644
57somatic hypermutation of immunoglobulin genes (GO:0016446)3.18166644
58DNA replication-dependent nucleosome organization (GO:0034723)3.17977468
59DNA replication-dependent nucleosome assembly (GO:0006335)3.17977468
60positive regulation of digestive system process (GO:0060456)3.17654336
61resolution of meiotic recombination intermediates (GO:0000712)3.17401992
62somite rostral/caudal axis specification (GO:0032525)3.16338918
63metaphase plate congression (GO:0051310)3.15282012
64RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.14076235
65meiotic nuclear division (GO:0007126)3.13331971
66regulation of histone H3-K27 methylation (GO:0061085)3.12279943
67establishment of chromosome localization (GO:0051303)3.12216957
68regulation of cilium movement (GO:0003352)3.11989166
69pore complex assembly (GO:0046931)3.10079395
70sister chromatid cohesion (GO:0007062)3.09984231
71meiosis I (GO:0007127)3.09924689
72regulation of corticosteroid hormone secretion (GO:2000846)3.05408393
73DNA synthesis involved in DNA repair (GO:0000731)3.02688037
74peptidyl-threonine dephosphorylation (GO:0035970)3.02237674
75histone H3-K36 demethylation (GO:0070544)3.00614642
76negative regulation of NF-kappaB import into nucleus (GO:0042347)3.00224059
77regulation of B cell receptor signaling pathway (GO:0050855)2.97994204
78mitochondrial DNA replication (GO:0006264)2.97939290
79DNA replication-independent nucleosome organization (GO:0034724)2.94841465
80DNA replication-independent nucleosome assembly (GO:0006336)2.94841465
81cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.94514345
82ribosome assembly (GO:0042255)2.93985344
83detection of external biotic stimulus (GO:0098581)2.93893956
84RNA-dependent DNA replication (GO:0006278)2.92150669
85deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.91915325
86positive regulation of uterine smooth muscle contraction (GO:0070474)2.89691634
87kinetochore organization (GO:0051383)2.89680258
88response to X-ray (GO:0010165)2.89355423
89regulation of mitotic metaphase/anaphase transition (GO:0030071)2.88506569
90regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.88506569
91gene silencing by RNA (GO:0031047)2.88152582
92regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.86985347
93peptidyl-lysine methylation (GO:0018022)2.85693959
94positive regulation of DNA-dependent DNA replication (GO:2000105)2.85669988
95positive regulation of histone H3-K4 methylation (GO:0051571)2.85261898
96positive regulation of male gonad development (GO:2000020)2.83998662
97antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.82543406
98meiotic chromosome segregation (GO:0045132)2.82193690
99negative regulation of mast cell activation (GO:0033004)2.81483613
100DNA deamination (GO:0045006)2.81355481
101regulation of sister chromatid segregation (GO:0033045)2.80901809
102regulation of mitotic sister chromatid separation (GO:0010965)2.80901809
103regulation of mitotic sister chromatid segregation (GO:0033047)2.80901809
104kinetochore assembly (GO:0051382)2.80721996
105CENP-A containing nucleosome assembly (GO:0034080)2.80334252
106postreplication repair (GO:0006301)2.79337178
107regulation of DNA-dependent DNA replication (GO:0090329)2.78166155
108formation of translation preinitiation complex (GO:0001731)2.77813737
109interferon-gamma production (GO:0032609)2.77611295
110regulation of male gonad development (GO:2000018)2.77013884
111centriole replication (GO:0007099)2.76995280
112nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.76185360
113developmental pigmentation (GO:0048066)2.75708292
114positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.75700474
115negative regulation of granulocyte differentiation (GO:0030853)2.75692661
116synaptonemal complex organization (GO:0070193)2.75232524
117peptidyl-lysine dimethylation (GO:0018027)2.74708914
118regulation of chromosome segregation (GO:0051983)2.74158849
119centriole assembly (GO:0098534)2.72565971
120regulation of double-strand break repair via homologous recombination (GO:0010569)2.72362616
121synaptonemal complex assembly (GO:0007130)2.71756774
122maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.71133794
123regulation of centrosome cycle (GO:0046605)2.70594272
124DNA-dependent DNA replication (GO:0006261)2.70056389
125proteasome assembly (GO:0043248)2.69551988
126chromatin remodeling at centromere (GO:0031055)2.69495393
127ER to Golgi vesicle-mediated transport (GO:0006888)2.69230514
128purine nucleobase biosynthetic process (GO:0009113)2.68400548
129positive regulation of interleukin-1 beta secretion (GO:0050718)2.68314096
130meiotic cell cycle process (GO:1903046)2.68072020
131spindle checkpoint (GO:0031577)2.68054437
132microtubule anchoring (GO:0034453)2.67941507
133positive regulation of chromosome segregation (GO:0051984)2.66930276
134positive regulation of developmental pigmentation (GO:0048087)2.66770385
135DNA catabolic process, exonucleolytic (GO:0000738)2.66319985
136modulation by virus of host process (GO:0019054)2.66269615
137mitotic spindle checkpoint (GO:0071174)2.63964530
138regulation of pigment cell differentiation (GO:0050932)2.63635067
139negative regulation of telomere maintenance (GO:0032205)2.62727479
140deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.60700265
141detection of biotic stimulus (GO:0009595)2.60540325
142auditory receptor cell stereocilium organization (GO:0060088)2.59838146
143DNA integration (GO:0015074)2.59750746
144B cell homeostasis (GO:0001782)2.56792375
145replication fork processing (GO:0031297)2.56366596
146regulation of interleukin-6 biosynthetic process (GO:0045408)2.55204550
147protein K6-linked ubiquitination (GO:0085020)2.54220724
148T cell lineage commitment (GO:0002360)2.53509940
149telomere maintenance (GO:0000723)2.53316929
150tRNA modification (GO:0006400)2.52187411
151regulation of interleukin-8 secretion (GO:2000482)2.51531657
152negative regulation of DNA recombination (GO:0045910)2.50001377
153pyrimidine dimer repair (GO:0006290)2.49917792
154regulation of helicase activity (GO:0051095)2.48583333
155positive regulation of cellular amide metabolic process (GO:0034250)2.48428786
156DNA methylation involved in gamete generation (GO:0043046)2.48378371
157telomere organization (GO:0032200)2.47631235
158mismatch repair (GO:0006298)2.47050671
159telomere maintenance via telomere lengthening (GO:0010833)2.46559619
160reciprocal DNA recombination (GO:0035825)2.43824269
161reciprocal meiotic recombination (GO:0007131)2.43824269
162CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.41774918
163lymphoid progenitor cell differentiation (GO:0002320)2.41434040
164histone H3-K9 modification (GO:0061647)2.39970486
165positive regulation of interleukin-1 secretion (GO:0050716)2.39414193
166adenosine metabolic process (GO:0046085)2.38110732
167synapsis (GO:0007129)2.35735129
168histone H3-K9 methylation (GO:0051567)2.35342430
169telomere maintenance via semi-conservative replication (GO:0032201)2.34662927
170I-kappaB phosphorylation (GO:0007252)2.34390667
171post-embryonic morphogenesis (GO:0009886)2.34306117
172cell differentiation involved in metanephros development (GO:0072202)2.33746129
173IMP biosynthetic process (GO:0006188)2.32054007
174negative regulation of phagocytosis (GO:0050765)2.31324001
175dentate gyrus development (GO:0021542)2.30561935
176nuclear pore organization (GO:0006999)2.30521026
177response to peptidoglycan (GO:0032494)2.30215286
178DNA replication initiation (GO:0006270)2.29716743
179sulfate transport (GO:0008272)2.29239306
180negative regulation of meiosis (GO:0045835)2.28945484
181regulation of telomere maintenance (GO:0032204)2.28939890
182negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.27568620
183negative regulation of translation, ncRNA-mediated (GO:0040033)2.27568620
184regulation of translation, ncRNA-mediated (GO:0045974)2.27568620
185response to host immune response (GO:0052572)2.27069347
186response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.27069347
187regulation of interleukin-1 beta secretion (GO:0050706)2.26821825
188cellular anion homeostasis (GO:0030002)2.26248332
189lateral ventricle development (GO:0021670)2.24767002

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.64615164
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.03860458
3PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.73588620
4TP63_19390658_ChIP-ChIP_HaCaT_Human2.68926500
5PCGF2_27294783_Chip-Seq_ESCs_Mouse2.64670238
6FLI1_27457419_Chip-Seq_LIVER_Mouse2.59056094
7NOTCH1_21737748_ChIP-Seq_TLL_Human2.46710050
8CREB1_15753290_ChIP-ChIP_HEK293T_Human2.44451188
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.38810358
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.37214528
11SUZ12_27294783_Chip-Seq_NPCs_Mouse2.34233424
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.32650066
13NFE2_27457419_Chip-Seq_LIVER_Mouse2.31700428
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.26791297
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.25782342
16GBX2_23144817_ChIP-Seq_PC3_Human2.25676243
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.22980671
18PADI4_21655091_ChIP-ChIP_MCF-7_Human2.22219767
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.21617229
20PCGF2_27294783_Chip-Seq_NPCs_Mouse2.20102299
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.16107305
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.15353656
23IRF8_21731497_ChIP-ChIP_J774_Mouse2.10096998
24ZFP57_27257070_Chip-Seq_ESCs_Mouse1.94717282
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.92269891
26MYC_18555785_ChIP-Seq_MESCs_Mouse1.86546532
27KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.80660028
28EZH2_27294783_Chip-Seq_NPCs_Mouse1.79930108
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.77745341
30EZH2_22144423_ChIP-Seq_EOC_Human1.77173772
31IGF1R_20145208_ChIP-Seq_DFB_Human1.75501574
32FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.73910351
33HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.73260030
34ELF1_17652178_ChIP-ChIP_JURKAT_Human1.68886570
35MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.68111090
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.67622108
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.65835287
38E2F1_18555785_Chip-Seq_ESCs_Mouse1.62129164
39SALL1_21062744_ChIP-ChIP_HESCs_Human1.62096261
40SUZ12_18555785_Chip-Seq_ESCs_Mouse1.61818318
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.61128753
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61019734
43NMYC_18555785_Chip-Seq_ESCs_Mouse1.60433846
44MYC_18940864_ChIP-ChIP_HL60_Human1.58954316
45STAT3_18555785_Chip-Seq_ESCs_Mouse1.56942480
46EWS_26573619_Chip-Seq_HEK293_Human1.54245340
47IRF1_19129219_ChIP-ChIP_H3396_Human1.53144557
48P53_22387025_ChIP-Seq_ESCs_Mouse1.53140272
49RUNX1_27457419_Chip-Seq_LIVER_Mouse1.50979393
50ETS1_20019798_ChIP-Seq_JURKAT_Human1.50180293
51IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.49128853
52STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.48816665
53EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.48610887
54TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.48172017
55NANOG_18555785_Chip-Seq_ESCs_Mouse1.47970566
56IRF8_27001747_Chip-Seq_BMDM_Mouse1.44926662
57MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.44884637
58FOXM1_23109430_ChIP-Seq_U2OS_Human1.44568361
59NELFA_20434984_ChIP-Seq_ESCs_Mouse1.44235132
60MYCN_18555785_ChIP-Seq_MESCs_Mouse1.44178336
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44095946
62YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43957023
63E2F1_21310950_ChIP-Seq_MCF-7_Human1.43907688
64PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.43735463
65ZNF274_21170338_ChIP-Seq_K562_Hela1.42572567
66OCT4_18555785_Chip-Seq_ESCs_Mouse1.42560388
67CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.41525219
68EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.41481390
69P300_18555785_Chip-Seq_ESCs_Mouse1.39777593
70KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.38596232
71POU5F1_16153702_ChIP-ChIP_HESCs_Human1.37518862
72ZFX_18555785_Chip-Seq_ESCs_Mouse1.37272751
73ESRRB_18555785_Chip-Seq_ESCs_Mouse1.36271500
74GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.35045681
75CBP_20019798_ChIP-Seq_JUKART_Human1.34707408
76IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34707408
77SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.32754973
78SCL_19346495_ChIP-Seq_HPC-7_Human1.31527487
79SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.30862142
80CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30539720
81FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.30381525
82PU1_27457419_Chip-Seq_LIVER_Mouse1.29985366
83SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.29416747
84FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.29228095
85SOX2_18555785_Chip-Seq_ESCs_Mouse1.29089902
86SRF_21415370_ChIP-Seq_HL-1_Mouse1.27960694
87CMYC_18555785_Chip-Seq_ESCs_Mouse1.27850204
88AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.26963599
89ER_23166858_ChIP-Seq_MCF-7_Human1.25750598
90SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.25611442
91KLF4_18555785_Chip-Seq_ESCs_Mouse1.25409542
92BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.25139799
93LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.24557772
94SMAD_19615063_ChIP-ChIP_OVARY_Human1.24555472
95HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.24139963
96P300_19829295_ChIP-Seq_ESCs_Human1.22364032
97STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.22164035
98SMAD1_18555785_Chip-Seq_ESCs_Mouse1.21083966
99CTCF_18555785_Chip-Seq_ESCs_Mouse1.20433356
100TAF15_26573619_Chip-Seq_HEK293_Human1.20356909
101BMI1_23680149_ChIP-Seq_NPCS_Mouse1.19970680
102CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19868003
103ERG_20887958_ChIP-Seq_HPC-7_Mouse1.19516066
104GABP_19822575_ChIP-Seq_HepG2_Human1.19383375
105E2F1_18555785_ChIP-Seq_MESCs_Mouse1.18695224
106RBPJ_22232070_ChIP-Seq_NCS_Mouse1.15938116
107VDR_22108803_ChIP-Seq_LS180_Human1.15614616
108FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14298053
109MYC_19030024_ChIP-ChIP_MESCs_Mouse1.14120352
110FUS_26573619_Chip-Seq_HEK293_Human1.13889817
111SPI1_23547873_ChIP-Seq_NB4_Human1.13062695
112MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.11337674
113TAL1_26923725_Chip-Seq_HPCs_Mouse1.11032918
114OCT4_21477851_ChIP-Seq_ESCs_Mouse1.10701814
115ZFX_18555785_ChIP-Seq_MESCs_Mouse1.10338750
116RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.10132877
117CRX_20693478_ChIP-Seq_RETINA_Mouse1.10090589
118CTBP2_25329375_ChIP-Seq_LNCAP_Human1.09260229
119RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.09246866
120MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09063388
121HOXB4_20404135_ChIP-ChIP_EML_Mouse1.08497167
122GATA1_22025678_ChIP-Seq_K562_Human1.07793468
123CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.07654139
124JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.05677088
125DCP1A_22483619_ChIP-Seq_HELA_Human1.05142700
126RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04000744
127STAT3_23295773_ChIP-Seq_U87_Human1.02864311
128SALL4_22934838_ChIP-ChIP_CD34+_Human1.02769050
129FOXP3_21729870_ChIP-Seq_TREG_Human1.02627924
130TTF2_22483619_ChIP-Seq_HELA_Human1.02618680
131ELK1_19687146_ChIP-ChIP_HELA_Human1.02482523
132RNF2_27304074_Chip-Seq_NSC_Mouse1.02395971
133GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01518636
134TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01191384
135SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.01141039
136VDR_23849224_ChIP-Seq_CD4+_Human0.99603158
137E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99055212
138FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.98727202
139CDX2_22108803_ChIP-Seq_LS180_Human0.98585976
140ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96801366
141UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96462020
142SMAD4_21799915_ChIP-Seq_A2780_Human0.92902147
143POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.92101794
144EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.91488628
145TFEB_21752829_ChIP-Seq_HELA_Human0.90839509
146TOP2B_26459242_ChIP-Seq_MCF-7_Human0.89541045
147KLF5_20875108_ChIP-Seq_MESCs_Mouse0.89324728
148TP53_22573176_ChIP-Seq_HFKS_Human0.87151890
149FOXM1_26456572_ChIP-Seq_MCF-7_Human0.82695207
150TCF4_22108803_ChIP-Seq_LS180_Human0.82024729
151FLI1_21867929_ChIP-Seq_TH2_Mouse0.81974867

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.62628187
2MP0008058_abnormal_DNA_repair3.44042798
3MP0001188_hyperpigmentation3.40035769
4MP0000566_synostosis3.18363939
5MP0001661_extended_life_span3.17501449
6MP0010094_abnormal_chromosome_stability2.95210865
7MP0002396_abnormal_hematopoietic_system2.81933289
8MP0000015_abnormal_ear_pigmentation2.71771827
9MP0009697_abnormal_copulation2.67576131
10MP0002132_abnormal_respiratory_system2.54356288
11MP0005410_abnormal_fertilization2.42435259
12MP0004957_abnormal_blastocyst_morpholog2.37796833
13MP0003693_abnormal_embryo_hatching2.37144093
14MP0001835_abnormal_antigen_presentation2.33234866
15MP0003111_abnormal_nucleus_morphology2.31262361
16MP0005645_abnormal_hypothalamus_physiol2.27295416
17MP0003221_abnormal_cardiomyocyte_apopto2.27191232
18MP0001929_abnormal_gametogenesis2.26371161
19MP0003941_abnormal_skin_development2.24116418
20MP0005174_abnormal_tail_pigmentation2.14205222
21MP0001986_abnormal_taste_sensitivity2.12552850
22MP0002277_abnormal_respiratory_mucosa2.12436001
23MP0008057_abnormal_DNA_replication2.11306020
24MP0005075_abnormal_melanosome_morpholog2.09590567
25MP0002009_preneoplasia1.99557172
26MP0000569_abnormal_digit_pigmentation1.97752147
27MP0003136_yellow_coat_color1.95068945
28MP0003787_abnormal_imprinting1.93234562
29MP0003567_abnormal_fetal_cardiomyocyte1.88340754
30MP0001145_abnormal_male_reproductive1.86822500
31MP0005171_absent_coat_pigmentation1.85699471
32MP0006072_abnormal_retinal_apoptosis1.82616358
33MP0003698_abnormal_male_reproductive1.81607144
34MP0000383_abnormal_hair_follicle1.81472463
35MP0003878_abnormal_ear_physiology1.80783963
36MP0005377_hearing/vestibular/ear_phenot1.80783963
37MP0008877_abnormal_DNA_methylation1.80357470
38MP0003121_genomic_imprinting1.76258663
39MP0002095_abnormal_skin_pigmentation1.75631600
40MP0000372_irregular_coat_pigmentation1.74975945
41MP0000427_abnormal_hair_cycle1.74494971
42MP0002102_abnormal_ear_morphology1.71078630
43MP0004381_abnormal_hair_follicle1.66891467
44MP0000371_diluted_coat_color1.66443338
45MP0000653_abnormal_sex_gland1.63523382
46MP0003763_abnormal_thymus_physiology1.62924785
47MP0005671_abnormal_response_to1.57612855
48MP0003077_abnormal_cell_cycle1.53357210
49MP0008007_abnormal_cellular_replicative1.52363739
50MP0005379_endocrine/exocrine_gland_phen1.50231887
51MP0003786_premature_aging1.49945699
52MP0010678_abnormal_skin_adnexa1.48535947
53MP0002419_abnormal_innate_immunity1.48358965
54MP0005451_abnormal_body_composition1.46911656
55MP0001984_abnormal_olfaction1.46881187
56MP0001800_abnormal_humoral_immune1.46173528
57MP0002148_abnormal_hypersensitivity_rea1.45320863
58MP0000490_abnormal_crypts_of1.44446340
59MP0002075_abnormal_coat/hair_pigmentati1.44097038
60MP0006035_abnormal_mitochondrial_morpho1.43118656
61MP0002452_abnormal_antigen_presenting1.42044853
62MP0003195_calcinosis1.41320221
63MP0001186_pigmentation_phenotype1.41091370
64MP0001697_abnormal_embryo_size1.37844047
65MP0002938_white_spotting1.37503569
66MP0003646_muscle_fatigue1.34552436
67MP0009785_altered_susceptibility_to1.31470211
68MP0005646_abnormal_pituitary_gland1.29372700
69MP0001819_abnormal_immune_cell1.29258830
70MP0001790_abnormal_immune_system1.28525251
71MP0005387_immune_system_phenotype1.28525251
72MP0002420_abnormal_adaptive_immunity1.28513643
73MP0000678_abnormal_parathyroid_gland1.25605920
74MP0005464_abnormal_platelet_physiology1.25546660
75MP0002723_abnormal_immune_serum1.25439478
76MP0002163_abnormal_gland_morphology1.25224090
77MP0002398_abnormal_bone_marrow1.25180389
78MP0000358_abnormal_cell_content/1.22990250
79MP0001672_abnormal_embryogenesis/_devel1.20324411
80MP0005380_embryogenesis_phenotype1.20324411
81MP0005000_abnormal_immune_tolerance1.19144829
82MP0005253_abnormal_eye_physiology1.16690413
83MP0003828_pulmonary_edema1.16235284
84MP0003119_abnormal_digestive_system1.16178115
85MP0002090_abnormal_vision1.16004961
86MP0002084_abnormal_developmental_patter1.14912922
87MP0002166_altered_tumor_susceptibility1.13568499
88MP0008004_abnormal_stomach_pH1.12228643
89MP0006276_abnormal_autonomic_nervous1.12031277
90MP0002638_abnormal_pupillary_reflex1.11088498
91MP0005310_abnormal_salivary_gland1.10671038
92MP0008995_early_reproductive_senescence1.09495557
93MP0000716_abnormal_immune_system1.09289947
94MP0000313_abnormal_cell_death1.08581240
95MP0003436_decreased_susceptibility_to1.05240298
96MP0000703_abnormal_thymus_morphology1.04947903
97MP0006054_spinal_hemorrhage1.03579368
98MP0002161_abnormal_fertility/fecundity1.03469173
99MP0000350_abnormal_cell_proliferation1.03194356
100MP0005025_abnormal_response_to1.03139832
101MP0003984_embryonic_growth_retardation1.02141900
102MP0000689_abnormal_spleen_morphology1.01132633
103MP0002088_abnormal_embryonic_growth/wei1.01008719
104MP0002254_reproductive_system_inflammat1.00201517
105MP0000631_abnormal_neuroendocrine_gland0.99622883
106MP0002722_abnormal_immune_system0.94363334
107MP0000681_abnormal_thyroid_gland0.94214429
108MP0002006_tumorigenesis0.92902779
109MP0002429_abnormal_blood_cell0.92825558
110MP0008875_abnormal_xenobiotic_pharmacok0.92713423
111MP0003718_maternal_effect0.92517303
112MP0001119_abnormal_female_reproductive0.92334304
113MP0006036_abnormal_mitochondrial_physio0.91913705
114MP0003011_delayed_dark_adaptation0.91484778
115MP0004197_abnormal_fetal_growth/weight/0.90488840
116MP0002160_abnormal_reproductive_system0.90484209
117MP0008961_abnormal_basal_metabolism0.90048974
118MP0005248_abnormal_Harderian_gland0.89323131
119MP0001730_embryonic_growth_arrest0.88660557
120MP0009764_decreased_sensitivity_to0.88082319
121MP0005389_reproductive_system_phenotype0.88000165
122MP0003724_increased_susceptibility_to0.87901220
123MP0010386_abnormal_urinary_bladder0.87270065
124MP0010307_abnormal_tumor_latency0.85429832
125MP0002210_abnormal_sex_determination0.83226745
126MP0000858_altered_metastatic_potential0.83023099
127MP0003172_abnormal_lysosome_physiology0.79606823
128MP0000647_abnormal_sebaceous_gland0.79520571
129MP0002177_abnormal_outer_ear0.79221913
130MP0003122_maternal_imprinting0.77661771
131MP0000013_abnormal_adipose_tissue0.77470011
132MP0009115_abnormal_fat_cell0.77270938
133MP0003868_abnormal_feces_composition0.77111670
134MP0002085_abnormal_embryonic_tissue0.76687571
135MP0002127_abnormal_cardiovascular_syste0.76619656
136MP0004782_abnormal_surfactant_physiolog0.75557241
137MP0009703_decreased_birth_body0.75485132
138MP0003943_abnormal_hepatobiliary_system0.74737196
139MP0002080_prenatal_lethality0.73722249
140MP0002735_abnormal_chemical_nociception0.72945649
141MP0001853_heart_inflammation0.71925932
142MP0002086_abnormal_extraembryonic_tissu0.71924706
143MP0001919_abnormal_reproductive_system0.71580013
144MP0005409_darkened_coat_color0.71221723
145MP0005670_abnormal_white_adipose0.71149217
146MP0005384_cellular_phenotype0.71075719
147MP0008260_abnormal_autophagy0.70714744
148MP0005391_vision/eye_phenotype0.69342022
149MP0001293_anophthalmia0.68759816
150MP0005257_abnormal_intraocular_pressure0.68721623
151MP0004019_abnormal_vitamin_homeostasis0.67312021
152MP0004808_abnormal_hematopoietic_stem0.66856988
153MP0002405_respiratory_system_inflammati0.66723354
154MP0001485_abnormal_pinna_reflex0.66708606
155MP0000639_abnormal_adrenal_gland0.66485130
156MP0003115_abnormal_respiratory_system0.66370242
157MP0001764_abnormal_homeostasis0.66279804
158MP0003890_abnormal_embryonic-extraembry0.65752285
159MP0003699_abnormal_female_reproductive0.65290520
160MP0002933_joint_inflammation0.64475712
161MP0008932_abnormal_embryonic_tissue0.64207396
162MP0004742_abnormal_vestibular_system0.64058106
163MP0003183_abnormal_peptide_metabolism0.63320090
164MP0002751_abnormal_autonomic_nervous0.63247996
165MP0000428_abnormal_craniofacial_morphol0.63195233
166MP0001286_abnormal_eye_development0.61397884
167MP0002269_muscular_atrophy0.60907918

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)6.07234044
2Chromsome breakage (HP:0040012)5.57352840
3Degeneration of the lateral corticospinal tracts (HP:0002314)5.17952355
4Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.17952355
5Duplicated collecting system (HP:0000081)4.70614941
6Gonadal dysgenesis (HP:0000133)4.65442389
7Abnormality of the renal collecting system (HP:0004742)4.32835766
8Prostate neoplasm (HP:0100787)3.78155850
9Abnormality of the corticospinal tract (HP:0002492)3.66893301
10Ectopic kidney (HP:0000086)3.52911159
11Renal cortical cysts (HP:0000803)3.50779975
12Abnormality of chromosome stability (HP:0003220)3.47593587
13Volvulus (HP:0002580)3.42180504
14Aplasia/Hypoplasia of the uvula (HP:0010293)3.40298628
15Abnormality of the preputium (HP:0100587)3.39460804
16Meckel diverticulum (HP:0002245)3.29368661
17Shoulder girdle muscle weakness (HP:0003547)3.18148946
18Abnormality of DNA repair (HP:0003254)3.12144683
19Abnormality of the ileum (HP:0001549)3.09285133
20Clubbing of toes (HP:0100760)3.05149564
21Papillary thyroid carcinoma (HP:0002895)3.02492720
22Testicular neoplasm (HP:0010788)2.88982864
23Osteomalacia (HP:0002749)2.87952528
24Amyotrophic lateral sclerosis (HP:0007354)2.86714880
25Cheilitis (HP:0100825)2.81893111
26Impaired vibration sensation in the lower limbs (HP:0002166)2.78350619
27Microvesicular hepatic steatosis (HP:0001414)2.74634467
28Unilateral renal agenesis (HP:0000122)2.74054561
29Methylmalonic acidemia (HP:0002912)2.73020851
30Hypoplastic left heart (HP:0004383)2.67056076
31Sex reversal (HP:0012245)2.66310654
32Abnormal sex determination (HP:0012244)2.66310654
33Abnormality of the labia minora (HP:0012880)2.63941071
34Ovarian neoplasm (HP:0100615)2.63439500
35Abnormality of the carotid arteries (HP:0005344)2.63333379
36Male pseudohermaphroditism (HP:0000037)2.58858938
37Abnormal lung lobation (HP:0002101)2.55872253
38Septo-optic dysplasia (HP:0100842)2.53688824
39Patchy hypopigmentation of hair (HP:0011365)2.53638154
40Abnormality of the prostate (HP:0008775)2.53437277
41Recurrent pneumonia (HP:0006532)2.53303640
42Bone marrow hypocellularity (HP:0005528)2.52453750
43White forelock (HP:0002211)2.52294660
44Urinary urgency (HP:0000012)2.48096952
45Protruding tongue (HP:0010808)2.45490003
46Clitoromegaly (HP:0000057)2.44252367
47Embryonal renal neoplasm (HP:0011794)2.40494461
48Recurrent abscess formation (HP:0002722)2.38689830
49Febrile seizures (HP:0002373)2.35659052
50Multiple enchondromatosis (HP:0005701)2.32855747
51Anomalous pulmonary venous return (HP:0010772)2.30848330
52IgM deficiency (HP:0002850)2.30688992
53Agnosia (HP:0010524)2.28539102
54Medulloblastoma (HP:0002885)2.26825202
55Abnormality of the renal cortex (HP:0011035)2.22147403
56Abnormality of pyrimidine metabolism (HP:0004353)2.21392839
57Atrophy/Degeneration involving motor neurons (HP:0007373)2.20237605
58Hypothermia (HP:0002045)2.19620802
59Thyroid carcinoma (HP:0002890)2.18673570
60Female pseudohermaphroditism (HP:0010458)2.18541461
61Absent thumb (HP:0009777)2.18244687
62Transposition of the great arteries (HP:0001669)2.13834871
63Abnormal connection of the cardiac segments (HP:0011545)2.13834871
64Abnormal ventriculo-arterial connection (HP:0011563)2.13834871
65Entropion (HP:0000621)2.12015363
66Abnormality of incisor morphology (HP:0011063)2.11653943
67Hyperglycinemia (HP:0002154)2.11520994
68Rimmed vacuoles (HP:0003805)2.11029843
69Oligodactyly (hands) (HP:0001180)2.10881397
70Alveolar cell carcinoma (HP:0006519)2.09930043
71Neoplasm of the oral cavity (HP:0100649)2.09890287
72Fair hair (HP:0002286)2.09406249
73Absent eyebrow (HP:0002223)2.08882180
74Rhabdomyosarcoma (HP:0002859)2.06381827
75True hermaphroditism (HP:0010459)2.06015715
76Proximal tubulopathy (HP:0000114)2.05256482
77Stomach cancer (HP:0012126)2.04864778
78Abnormality of methionine metabolism (HP:0010901)2.04711495
79Short tibia (HP:0005736)2.04585960
80Chronic diarrhea (HP:0002028)2.04199593
81Hypergonadotropic hypogonadism (HP:0000815)2.03863469
82Urinary bladder sphincter dysfunction (HP:0002839)2.03384293
83Facial hemangioma (HP:0000329)2.01179225
84Type I transferrin isoform profile (HP:0003642)2.01117678
85Reduced antithrombin III activity (HP:0001976)2.00964936
86Capillary hemangiomas (HP:0005306)1.99946240
87Hypoplastic heart (HP:0001961)1.99912805
88Upper limb muscle weakness (HP:0003484)1.99207984
89Inappropriate behavior (HP:0000719)1.99205200
90Myelodysplasia (HP:0002863)1.98944295
91Reticulocytopenia (HP:0001896)1.98842039
92Azoospermia (HP:0000027)1.98800479
93Small intestinal stenosis (HP:0012848)1.98673279
94Duodenal stenosis (HP:0100867)1.98673279
95Premature graying of hair (HP:0002216)1.98386710
96Congenital primary aphakia (HP:0007707)1.97759839
97Generalized hypopigmentation of hair (HP:0011358)1.97697145
98Upper motor neuron abnormality (HP:0002127)1.97415921
99Tubulointerstitial nephritis (HP:0001970)1.97391720
100Methylmalonic aciduria (HP:0012120)1.95374493
101Absent radius (HP:0003974)1.95082077
102Oligohydramnios (HP:0001562)1.94993409
103Retrobulbar optic neuritis (HP:0100654)1.94968141
104Optic neuritis (HP:0100653)1.94968141
105Gonadotropin excess (HP:0000837)1.93893732
106Duplication of thumb phalanx (HP:0009942)1.93077888
107Aplasia/Hypoplasia of the tibia (HP:0005772)1.92686095
108Medial flaring of the eyebrow (HP:0010747)1.92615461
109Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.92033487
110Abnormality of alanine metabolism (HP:0010916)1.92033487
111Hyperalaninemia (HP:0003348)1.92033487
112Birth length less than 3rd percentile (HP:0003561)1.91759722
113IgG deficiency (HP:0004315)1.91589117
114Congenital sensorineural hearing impairment (HP:0008527)1.89395246
115Absent/shortened dynein arms (HP:0200106)1.89176416
116Dynein arm defect of respiratory motile cilia (HP:0012255)1.89176416
117Chronic mucocutaneous candidiasis (HP:0002728)1.86546424
118Recurrent cutaneous fungal infections (HP:0011370)1.86546424
119Type II lissencephaly (HP:0007260)1.86046837
120Keratitis (HP:0000491)1.85069643
121Mediastinal lymphadenopathy (HP:0100721)1.84920871
122Colon cancer (HP:0003003)1.84685673
123Triphalangeal thumb (HP:0001199)1.84412332
124Basal ganglia calcification (HP:0002135)1.84144310
125Prominent nose (HP:0000448)1.83637978
126Oligodactyly (HP:0012165)1.82962491
127Aplasia/Hypoplasia of the earlobes (HP:0009906)1.82274803
128Lymphoma (HP:0002665)1.81568247
129Aplasia involving forearm bones (HP:0009822)1.81425749
130Absent forearm bone (HP:0003953)1.81425749
131Abnormality of the pulmonary veins (HP:0011718)1.80990890
132Lower limb hyperreflexia (HP:0002395)1.79797672
133Eczematoid dermatitis (HP:0000976)1.79302340
134Ureteral duplication (HP:0000073)1.79226820
135Conjugated hyperbilirubinemia (HP:0002908)1.78386603
136Myositis (HP:0100614)1.77673560
137Obstructive lung disease (HP:0006536)1.76170096
138Chronic obstructive pulmonary disease (HP:0006510)1.76170096
139Median cleft lip (HP:0000161)1.75609972
140Impulsivity (HP:0100710)1.75537069
141Abnormality of chromosome segregation (HP:0002916)1.75313404
142Abnormality of the incisor (HP:0000676)1.75127313
143Impaired vibratory sensation (HP:0002495)1.74868484
144Disinhibition (HP:0000734)1.74482111
145Neoplasm of the tracheobronchial system (HP:0100552)1.73807776
146Meningitis (HP:0001287)1.73712777
147Genetic anticipation (HP:0003743)1.73545817
148Recurrent lower respiratory tract infections (HP:0002783)1.73419383
149Abnormality of the lower motor neuron (HP:0002366)1.72950330
150Abnormal delayed hypersensitivity skin test (HP:0002963)1.72093046
151Sloping forehead (HP:0000340)1.72067682
152Abnormality of the duodenum (HP:0002246)1.71854504
153Abnormality of serum amino acid levels (HP:0003112)1.70902397
154Recurrent bacterial skin infections (HP:0005406)1.70766219
155Cone-rod dystrophy (HP:0000548)1.69804080
156Abnormality of dental color (HP:0011073)1.69071615
157Renal agenesis (HP:0000104)1.68949611
158Abnormality of the clitoris (HP:0000056)1.68533284
159Primary adrenal insufficiency (HP:0008207)1.68526481
160Gait imbalance (HP:0002141)1.67642478
161Carpal bone hypoplasia (HP:0001498)1.67358434
162Leukopenia (HP:0001882)1.66974810
163Genital tract atresia (HP:0001827)1.66558409
164Drooling (HP:0002307)1.66484580
165Lymphopenia (HP:0001888)1.66315852
166Morphological abnormality of the pyramidal tract (HP:0002062)1.64945446
167Hip dysplasia (HP:0001385)1.64703528
168Chronic hepatic failure (HP:0100626)1.64244652
169Nephroblastoma (Wilms tumor) (HP:0002667)1.64028234
170Abnormal protein glycosylation (HP:0012346)1.63945772
171Abnormal glycosylation (HP:0012345)1.63945772
172Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.63945772
173Abnormal protein N-linked glycosylation (HP:0012347)1.63945772
174Ectropion (HP:0000656)1.63394943
175Absent septum pellucidum (HP:0001331)1.63312760
176Abnormal spermatogenesis (HP:0008669)1.63112068
177Bilateral sensorineural hearing impairment (HP:0008619)1.63071686
178Abnormal hair whorl (HP:0010721)1.61384854
179Bile duct proliferation (HP:0001408)1.61248005
180Abnormal biliary tract physiology (HP:0012439)1.61248005

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K24.07373498
2SIK33.81792569
3ZAK3.47829913
4MST42.92684695
5SIK22.73422975
6IRAK32.73363498
7STK162.72550502
8TXK2.72275860
9MAP3K142.60758411
10MAP3K42.55876706
11SRPK12.34819295
12MKNK22.19276540
13EIF2AK22.14204723
14IRAK42.10179944
15CASK2.09934263
16BMPR1B2.03917652
17BRD41.85554068
18CLK11.85376324
19TNIK1.83469084
20INSRR1.81967162
21CDK191.73480247
22ERBB31.71649692
23TRIM281.67760626
24TEC1.65746535
25PLK21.64624464
26MKNK11.63808829
27BLK1.56915324
28TTK1.44284215
29ATR1.39673055
30TGFBR21.33387145
31CSNK1G11.32497567
32JAK31.29258038
33DYRK31.27872537
34YES11.27060977
35CDC71.25820032
36PLK41.20492280
37OXSR11.19681547
38PDK21.18319915
39STK38L1.17276279
40CDK81.15799345
41NEK61.14848119
42BMPR21.14345909
43ADRBK21.14240142
44BRSK21.11418861
45PBK1.10298998
46EGFR1.08735383
47MARK31.07584053
48FLT31.02980506
49BCR0.99268685
50CHEK20.97792895
51PINK10.95958416
52CSNK1A1L0.95196416
53FRK0.94773657
54CDK30.94026215
55KIT0.93150151
56TIE10.92325003
57STK390.92230849
58CSNK1G20.92088182
59MAPK130.91560545
60AKT30.90997755
61CSNK1G30.90786166
62SIK10.89507156
63LATS10.89264637
64GRK70.88811234
65NEK90.85429810
66CDK70.84184981
67ACVR1B0.83894004
68PRPF4B0.83608836
69BTK0.79842607
70PLK10.78884831
71IKBKB0.78849051
72PNCK0.78548591
73BUB10.77306406
74SGK20.76673812
75MAP2K70.75977953
76NUAK10.75004905
77NLK0.74519350
78LYN0.74371448
79IKBKE0.73549806
80ZAP700.73243561
81MAP4K10.72302472
82VRK10.72286577
83TLK10.71702237
84NEK10.70120158
85CDK120.69221493
86STK40.69015585
87MAP3K60.67337036
88PRKCE0.66852729
89PLK30.66464233
90SYK0.65683087
91GRK10.65628673
92ATM0.65469706
93STK240.63580860
94CSF1R0.63519560
95PASK0.61496263
96TNK20.61106905
97ERBB40.60926642
98EPHA20.60594859
99STK30.60135103
100CHUK0.58281538
101CDK40.56500113
102LCK0.56499037
103NME20.54955236
104CAMK1G0.54207358
105TYK20.54076458
106EIF2AK10.52573249
107HCK0.52227361
108PIM10.51404364
109CHEK10.50898059
110EIF2AK30.50378355
111NEK20.49825897
112WNK30.49070581
113PIK3CG0.48557879
114MAP3K50.48526387
115AURKB0.47767732
116CDK20.47026283
117CDK10.46486189
118EPHA30.45542428
119RIPK40.45505272
120ITK0.45474951
121IRAK10.45138762
122TGFBR10.44910706
123ERBB20.44340331
124MAPK70.42141850
125RPS6KB10.41884948
126RPS6KA40.41868524
127RAF10.39107990
128AKT10.38587235
129NTRK30.36832693
130WEE10.36255722
131CDK60.36231238
132MET0.36202186
133JAK10.35302867
134DYRK1A0.34918839
135CSNK2A10.33297260
136STK100.33117062
137PRKCI0.32843267
138IGF1R0.31475724
139TAOK30.31405892
140TSSK60.31373486
141MAP2K40.30265411
142MAPK140.28129978
143PRKDC0.26902166
144OBSCN0.25816719

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.06455314
2Fanconi anemia pathway_Homo sapiens_hsa034603.74812933
3Homologous recombination_Homo sapiens_hsa034403.54609518
4DNA replication_Homo sapiens_hsa030302.68242285
5Propanoate metabolism_Homo sapiens_hsa006402.67064430
6One carbon pool by folate_Homo sapiens_hsa006702.65795984
7Non-homologous end-joining_Homo sapiens_hsa034502.65245418
8Mismatch repair_Homo sapiens_hsa034302.58456214
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.46248226
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.31303376
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.23954400
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.11781176
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.07323368
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.05030350
15Base excision repair_Homo sapiens_hsa034101.99764773
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.98159545
17Primary immunodeficiency_Homo sapiens_hsa053401.84481208
18Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.76824738
19Basal transcription factors_Homo sapiens_hsa030221.66199862
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.62822705
21Butanoate metabolism_Homo sapiens_hsa006501.58479875
22Pyrimidine metabolism_Homo sapiens_hsa002401.56466043
23Nucleotide excision repair_Homo sapiens_hsa034201.55932855
24RNA polymerase_Homo sapiens_hsa030201.54870761
25Oocyte meiosis_Homo sapiens_hsa041141.54489674
26Measles_Homo sapiens_hsa051621.51746864
27Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.51505917
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.50125878
29NOD-like receptor signaling pathway_Homo sapiens_hsa046211.49422141
30Hematopoietic cell lineage_Homo sapiens_hsa046401.49210415
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.48279704
32Steroid biosynthesis_Homo sapiens_hsa001001.46694934
33Cell cycle_Homo sapiens_hsa041101.45703056
34Herpes simplex infection_Homo sapiens_hsa051681.44161693
35Spliceosome_Homo sapiens_hsa030401.36741300
36Pyruvate metabolism_Homo sapiens_hsa006201.35787450
37Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.33531081
38Toll-like receptor signaling pathway_Homo sapiens_hsa046201.32317193
39Allograft rejection_Homo sapiens_hsa053301.24210664
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.22480645
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.19703545
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.19491257
43Graft-versus-host disease_Homo sapiens_hsa053321.17553866
44Fatty acid elongation_Homo sapiens_hsa000621.17169643
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.15620936
46Staphylococcus aureus infection_Homo sapiens_hsa051501.13256981
47RNA degradation_Homo sapiens_hsa030181.11720753
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.10361835
49Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.09325864
50Purine metabolism_Homo sapiens_hsa002301.06381668
51Autoimmune thyroid disease_Homo sapiens_hsa053201.05045821
52Leishmaniasis_Homo sapiens_hsa051401.05015647
53Circadian rhythm_Homo sapiens_hsa047101.03509709
54RNA transport_Homo sapiens_hsa030131.03193849
55p53 signaling pathway_Homo sapiens_hsa041151.00775221
56Folate biosynthesis_Homo sapiens_hsa007900.99842221
57Asthma_Homo sapiens_hsa053100.98196774
58Transcriptional misregulation in cancer_Homo sapiens_hsa052020.97954301
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.97937232
60Caffeine metabolism_Homo sapiens_hsa002320.93915131
61Glycosaminoglycan degradation_Homo sapiens_hsa005310.90817874
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.85637256
63Osteoclast differentiation_Homo sapiens_hsa043800.84955758
64Other glycan degradation_Homo sapiens_hsa005110.84172701
65Influenza A_Homo sapiens_hsa051640.80731848
66mRNA surveillance pathway_Homo sapiens_hsa030150.80063461
67SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79833860
68Epstein-Barr virus infection_Homo sapiens_hsa051690.79114530
69Jak-STAT signaling pathway_Homo sapiens_hsa046300.78761689
70Systemic lupus erythematosus_Homo sapiens_hsa053220.77155649
71Regulation of autophagy_Homo sapiens_hsa041400.75165690
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74614604
73Hepatitis B_Homo sapiens_hsa051610.74502300
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73664534
75Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.72927502
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.69047996
77Arachidonic acid metabolism_Homo sapiens_hsa005900.68814515
78Legionellosis_Homo sapiens_hsa051340.68629708
79Apoptosis_Homo sapiens_hsa042100.68561803
80Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.68501273
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67335207
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.66775854
83HTLV-I infection_Homo sapiens_hsa051660.64915283
84Vitamin digestion and absorption_Homo sapiens_hsa049770.64137942
85Type I diabetes mellitus_Homo sapiens_hsa049400.63947163
86Carbon metabolism_Homo sapiens_hsa012000.62798142
87Hedgehog signaling pathway_Homo sapiens_hsa043400.62160765
88Drug metabolism - other enzymes_Homo sapiens_hsa009830.60808936
89Lysine degradation_Homo sapiens_hsa003100.57699868
90B cell receptor signaling pathway_Homo sapiens_hsa046620.57481351
91Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56562980
92Hepatitis C_Homo sapiens_hsa051600.56396526
93Small cell lung cancer_Homo sapiens_hsa052220.55735989
94Nicotine addiction_Homo sapiens_hsa050330.54227928
95TNF signaling pathway_Homo sapiens_hsa046680.52985338
96Antigen processing and presentation_Homo sapiens_hsa046120.52731180
97Tuberculosis_Homo sapiens_hsa051520.52692091
98T cell receptor signaling pathway_Homo sapiens_hsa046600.52683448
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50800418
100Peroxisome_Homo sapiens_hsa041460.50239173
101Proteasome_Homo sapiens_hsa030500.49094107
102Fatty acid metabolism_Homo sapiens_hsa012120.48435879
103beta-Alanine metabolism_Homo sapiens_hsa004100.48248409
104Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48215967
105Taste transduction_Homo sapiens_hsa047420.47584689
106Phototransduction_Homo sapiens_hsa047440.46862743
107Protein export_Homo sapiens_hsa030600.46771316
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45632316
109Maturity onset diabetes of the young_Homo sapiens_hsa049500.43134837
110Adherens junction_Homo sapiens_hsa045200.43093992
111Fatty acid degradation_Homo sapiens_hsa000710.42359227
112Selenocompound metabolism_Homo sapiens_hsa004500.42280984
113Phagosome_Homo sapiens_hsa041450.42004736
114Rheumatoid arthritis_Homo sapiens_hsa053230.41482090
115Metabolic pathways_Homo sapiens_hsa011000.40452362
116Melanoma_Homo sapiens_hsa052180.39496429
117Acute myeloid leukemia_Homo sapiens_hsa052210.39188140
118Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.39101441
119Prostate cancer_Homo sapiens_hsa052150.38890999
120Notch signaling pathway_Homo sapiens_hsa043300.38621923
121Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37264731
122Viral carcinogenesis_Homo sapiens_hsa052030.36827323
123FoxO signaling pathway_Homo sapiens_hsa040680.36335148
124Viral myocarditis_Homo sapiens_hsa054160.36126464
125N-Glycan biosynthesis_Homo sapiens_hsa005100.35732007
126TGF-beta signaling pathway_Homo sapiens_hsa043500.35422039
127Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.34193319
128Pertussis_Homo sapiens_hsa051330.34192090
129Inositol phosphate metabolism_Homo sapiens_hsa005620.34034748
130Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.33659876
131Chemokine signaling pathway_Homo sapiens_hsa040620.32760162
132Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.30733557
133Huntingtons disease_Homo sapiens_hsa050160.30147325
134Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.27859419
135Colorectal cancer_Homo sapiens_hsa052100.26790861
136Primary bile acid biosynthesis_Homo sapiens_hsa001200.25625972
137Glycerophospholipid metabolism_Homo sapiens_hsa005640.25074466
138Ether lipid metabolism_Homo sapiens_hsa005650.23713388
139Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.22784509
140Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.19812721
141Longevity regulating pathway - mammal_Homo sapiens_hsa042110.19752805
142Sphingolipid metabolism_Homo sapiens_hsa006000.14347610
1432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.12913657
144Parkinsons disease_Homo sapiens_hsa050120.11142355
145Alcoholism_Homo sapiens_hsa050340.11001077
146Pentose and glucuronate interconversions_Homo sapiens_hsa000400.09991933
147Oxidative phosphorylation_Homo sapiens_hsa001900.08033906
148Tryptophan metabolism_Homo sapiens_hsa003800.07775713

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