PRND

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is found on chromosome 20, approximately 20 kbp downstream of the gene encoding cellular prion protein, to which it is biochemically and structurally similar. The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that is found predominantly in testis. Mutations in this gene may lead to neurological disorders. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1male sex determination (GO:0030238)9.67063359
2regulation of respiratory burst (GO:0060263)8.95203055
3heart valve formation (GO:0003188)8.19515077
4positive regulation of glycogen biosynthetic process (GO:0045725)8.15464027
5negative regulation of protein localization to cell surface (GO:2000009)7.82001545
6Notch signaling involved in heart development (GO:0061314)7.40395580
7atrial cardiac muscle cell action potential (GO:0086014)7.39311473
8ventricular trabecula myocardium morphogenesis (GO:0003222)7.18173456
9positive regulation of glycogen metabolic process (GO:0070875)7.08331808
10lymph vessel development (GO:0001945)6.70768061
11regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)6.60025372
12ovulation from ovarian follicle (GO:0001542)6.34333969
13endoderm formation (GO:0001706)6.30520646
14gap junction assembly (GO:0016264)6.16077657
15arginine catabolic process (GO:0006527)6.14333423
16glomerular filtration (GO:0003094)6.05885819
17bundle of His cell to Purkinje myocyte communication (GO:0086069)5.86762408
18retina vasculature morphogenesis in camera-type eye (GO:0061299)5.84842665
19modulation by virus of host morphology or physiology (GO:0019048)5.76092514
20activation of protein kinase B activity (GO:0032148)5.70947537
21heart trabecula morphogenesis (GO:0061384)5.62466019
22sex determination (GO:0007530)5.58028955
23angiogenesis involved in wound healing (GO:0060055)5.56381902
24positive regulation of vasculogenesis (GO:2001214)5.42875174
25renal filtration (GO:0097205)5.34463135
26regulation of sarcomere organization (GO:0060297)4.87955026
27regulation of glycolytic process (GO:0006110)4.63081117
28regulation of glucan biosynthetic process (GO:0010962)4.58169389
29regulation of glycogen biosynthetic process (GO:0005979)4.58169389
30trabecula morphogenesis (GO:0061383)4.55754540
31response to fluid shear stress (GO:0034405)4.53789494
32Rap protein signal transduction (GO:0032486)4.44932371
33endothelial tube morphogenesis (GO:0061154)4.44396883
34morphogenesis of an endothelium (GO:0003159)4.44396883
35cellular response to fluid shear stress (GO:0071498)4.34408721
36transcytosis (GO:0045056)4.31961776
37endothelium development (GO:0003158)4.31324983
38regulation of integrin-mediated signaling pathway (GO:2001044)4.26078214
39negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)4.23429503
40establishment of planar polarity (GO:0001736)4.19584536
41establishment of tissue polarity (GO:0007164)4.19584536
42regulation of endothelial cell differentiation (GO:0045601)4.18192829
43regulation of vasculogenesis (GO:2001212)4.13175169
44glomerular visceral epithelial cell development (GO:0072015)4.10350081
45negative regulation of dendrite morphogenesis (GO:0050774)4.09947095
46glomerular basement membrane development (GO:0032836)4.07824018
47long term synaptic depression (GO:0060292)4.05508723
48vascular endothelial growth factor signaling pathway (GO:0038084)3.96123646
49membrane tubulation (GO:0097320)3.84214638
50cardiac epithelial to mesenchymal transition (GO:0060317)3.84194361
51presynaptic membrane assembly (GO:0097105)3.83177579
52positive regulation of glucose metabolic process (GO:0010907)3.79288353
53ventricular septum development (GO:0003281)3.71700731
54regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.70461812
55modification by symbiont of host morphology or physiology (GO:0044003)3.69291140
56regulation of carbohydrate catabolic process (GO:0043470)3.69100073
57regulation of cellular carbohydrate catabolic process (GO:0043471)3.69100073
58embryonic camera-type eye morphogenesis (GO:0048596)3.69008071
59heparin metabolic process (GO:0030202)3.68908212
60heparin biosynthetic process (GO:0030210)3.68908212
61basement membrane organization (GO:0071711)3.66922827
62positive regulation of cardiac muscle cell differentiation (GO:2000727)3.64345222
63epithelial cell differentiation involved in kidney development (GO:0035850)3.63694416
64negative regulation of neurological system process (GO:0031645)3.63019213
65platelet-derived growth factor receptor signaling pathway (GO:0048008)3.62905401
66regulation of glycogen metabolic process (GO:0070873)3.61652438
67negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.59281733
68regulation of polysaccharide biosynthetic process (GO:0032885)3.57781269
69glomerular epithelial cell development (GO:0072310)3.56975968
70dendritic spine organization (GO:0097061)3.54838566
71dendritic spine morphogenesis (GO:0060997)3.53511885
72dentate gyrus development (GO:0021542)3.52287436
73hematopoietic stem cell proliferation (GO:0071425)3.51694873
74macrophage activation (GO:0042116)3.51129872
75response to laminar fluid shear stress (GO:0034616)3.50925673
76negative regulation of Rho protein signal transduction (GO:0035024)3.44463649
77positive regulation of protein homodimerization activity (GO:0090073)3.42938032
78cell surface receptor signaling pathway involved in heart development (GO:0061311)3.41287171
79negative regulation of blood vessel endothelial cell migration (GO:0043537)3.39984866
80regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)3.38026988
81sprouting angiogenesis (GO:0002040)3.37521461
82blood vessel maturation (GO:0001955)3.37060214
83arginine metabolic process (GO:0006525)3.33715387
84regulation of protein localization to cell surface (GO:2000008)3.30092997
85ovulation (GO:0030728)3.29064224
86plasma membrane repair (GO:0001778)3.27389748
87peptidyl-tyrosine autophosphorylation (GO:0038083)3.26322407
88lymphangiogenesis (GO:0001946)3.26214888
89positive regulation of guanylate cyclase activity (GO:0031284)3.25547711
90prostate gland growth (GO:0060736)3.22647852
91positive regulation of glucose import (GO:0046326)3.20321369
92negative regulation of phagocytosis (GO:0050765)3.19395103
93positive regulation of nitric oxide biosynthetic process (GO:0045429)3.18800976
94epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.17658156
95regulation of protein homodimerization activity (GO:0043496)3.17452869
96blood vessel remodeling (GO:0001974)3.15040889
97cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.14322915
98negative regulation of endothelial cell migration (GO:0010596)3.13746847
99regulation of extracellular matrix disassembly (GO:0010715)3.13044241
100positive regulation of smooth muscle cell migration (GO:0014911)3.08969853
101presynaptic membrane organization (GO:0097090)3.08056452
102patterning of blood vessels (GO:0001569)3.07005424
103positive regulation of Rap GTPase activity (GO:0032854)3.06387291
104negative regulation of adherens junction organization (GO:1903392)3.06384773
105negative regulation of focal adhesion assembly (GO:0051895)3.06384773
106negative regulation of cell junction assembly (GO:1901889)3.06384773
107establishment of endothelial barrier (GO:0061028)3.05112357
108cardiac ventricle morphogenesis (GO:0003208)3.04683775
109phosphorylated carbohydrate dephosphorylation (GO:0046838)3.03592419
110inositol phosphate dephosphorylation (GO:0046855)3.03592419
111germinal center formation (GO:0002467)3.03481152
112cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.01941096
113regulation of nitric oxide biosynthetic process (GO:0045428)3.00700965
114negative regulation of dendrite development (GO:2000171)2.98181845
115regulation of dendritic spine morphogenesis (GO:0061001)2.93054487
116endothelial cell differentiation (GO:0045446)2.91370307
117regulation of polysaccharide metabolic process (GO:0032881)2.90079694
118response to gravity (GO:0009629)2.89865582
119heart morphogenesis (GO:0003007)2.89651165
120wound healing, spreading of epidermal cells (GO:0035313)2.86555707
121positive regulation of endothelial cell differentiation (GO:0045603)2.86241636
122positive regulation of focal adhesion assembly (GO:0051894)2.85538817
123positive regulation of cell junction assembly (GO:1901890)2.85538817
124alanine transport (GO:0032328)2.85455166
125regulation of guanylate cyclase activity (GO:0031282)2.85448069
126cardiac septum development (GO:0003279)2.84641422
127cytokinetic process (GO:0032506)2.83961079
128regulation of dendritic spine development (GO:0060998)2.83682085
129heart valve morphogenesis (GO:0003179)2.81833982
130mitochondrion distribution (GO:0048311)2.80928169
131aorta morphogenesis (GO:0035909)2.80030534
132regulation of muscle adaptation (GO:0043502)2.79598959
133lipopolysaccharide-mediated signaling pathway (GO:0031663)2.78197633
134negative regulation of platelet activation (GO:0010544)2.77667122
135vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.77381402
136negative regulation of endothelial cell apoptotic process (GO:2000352)2.77345602
137venous blood vessel morphogenesis (GO:0048845)2.76812071
138polyamine biosynthetic process (GO:0006596)2.75648693
139negative regulation of nitric oxide biosynthetic process (GO:0045019)2.75395599
140cardiac chamber morphogenesis (GO:0003206)2.74255046
141virion attachment to host cell (GO:0019062)2.73647592
142adhesion of symbiont to host cell (GO:0044650)2.73647592
143negative regulation of smooth muscle cell migration (GO:0014912)2.72437474
144regulation of retinoic acid receptor signaling pathway (GO:0048385)2.71507723
145heart field specification (GO:0003128)2.71234304
146secondary heart field specification (GO:0003139)2.71234304
147regulation of germinal center formation (GO:0002634)2.71106075
148endothelial cell migration (GO:0043542)2.70620177
149nitric oxide mediated signal transduction (GO:0007263)2.70362319
150G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.69975512
151amine catabolic process (GO:0009310)2.69284185
152cellular biogenic amine catabolic process (GO:0042402)2.69284185
153membrane assembly (GO:0071709)2.69239626
154regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.67726160
155cardiac myofibril assembly (GO:0055003)2.66920910
156response to pheromone (GO:0019236)2.65893160
157proline transport (GO:0015824)2.65747291
158nitric oxide biosynthetic process (GO:0006809)2.64808276
159cell communication by electrical coupling (GO:0010644)2.62989544
160protein localization to cilium (GO:0061512)2.59565166
161execution phase of apoptosis (GO:0097194)2.59183343
162positive regulation of glucose transport (GO:0010828)2.57298903
163nucleotide transmembrane transport (GO:1901679)2.51501731
164positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)2.51268957
165establishment of epithelial cell polarity (GO:0090162)2.46970546
166artery development (GO:0060840)2.46726851
167vasculogenesis (GO:0001570)2.45604571
168angiogenesis (GO:0001525)2.42956489
169Notch receptor processing (GO:0007220)2.42858278
170positive regulation of mitosis (GO:0045840)2.41395633
171cAMP biosynthetic process (GO:0006171)2.39314427
172positive regulation of respiratory burst (GO:0060267)16.8460757
173exocrine pancreas development (GO:0031017)13.0923556
174protein heterotetramerization (GO:0051290)10.5451493
175positive regulation of glycolytic process (GO:0045821)10.0311750

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.95530300
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.87931159
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.40712252
4GATA2_21666600_ChIP-Seq_HMVEC_Human3.19869168
5STAT6_21828071_ChIP-Seq_BEAS2B_Human3.17830404
6TRIM28_21343339_ChIP-Seq_HEK293_Human3.11983686
7ZNF274_21170338_ChIP-Seq_K562_Hela3.10934161
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.76066061
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.44850541
10VDR_22108803_ChIP-Seq_LS180_Human2.36633757
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.35645327
12WT1_19549856_ChIP-ChIP_CCG9911_Human2.28257490
13ZNF217_24962896_ChIP-Seq_MCF-7_Human2.26045383
14SMAD_19615063_ChIP-ChIP_OVARY_Human2.12585606
15SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.95034335
16FUS_26573619_Chip-Seq_HEK293_Human1.93876059
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.93523719
18BCAT_22108803_ChIP-Seq_LS180_Human1.83745133
19TCF4_22108803_ChIP-Seq_LS180_Human1.79612411
20EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.76763803
21EZH2_18974828_ChIP-Seq_MESCs_Mouse1.73223676
22RNF2_18974828_ChIP-Seq_MESCs_Mouse1.73223676
23ELF1_17652178_ChIP-ChIP_JURKAT_Human1.72685685
24DROSHA_22980978_ChIP-Seq_HELA_Human1.67455996
25EP300_21415370_ChIP-Seq_HL-1_Mouse1.64763843
26SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.64748297
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.64323824
28RARG_19884340_ChIP-ChIP_MEFs_Mouse1.63816094
29AR_21572438_ChIP-Seq_LNCaP_Human1.63673784
30GBX2_23144817_ChIP-Seq_PC3_Human1.63635507
31SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.63458428
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.63231504
33CJUN_26792858_Chip-Seq_BT549_Human1.62082585
34AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.61104510
35POU3F2_20337985_ChIP-ChIP_501MEL_Human1.59471904
36AR_25329375_ChIP-Seq_VCAP_Human1.59331856
37STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.59323607
38NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.57578636
39EED_16625203_ChIP-ChIP_MESCs_Mouse1.56369677
40EWS_26573619_Chip-Seq_HEK293_Human1.55595581
41AHR_22903824_ChIP-Seq_MCF-7_Human1.55176080
42* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.53657494
43CBP_20019798_ChIP-Seq_JUKART_Human1.53452876
44IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.53452876
45TP53_18474530_ChIP-ChIP_U2OS_Human1.49389374
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48338597
47FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.47512745
48UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.47295739
49ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.47127447
50PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.47086911
51RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46806606
52SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.45652408
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43016549
54SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.40329750
55EZH2_27304074_Chip-Seq_ESCs_Mouse1.39169157
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.39045650
57TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37272576
58POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.37272576
59VDR_24787735_ChIP-Seq_THP-1_Human1.37177157
60EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.36163391
61CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.35903897
62OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35754180
63MTF2_20144788_ChIP-Seq_MESCs_Mouse1.35466343
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.35184244
65PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.33247634
66RNF2_27304074_Chip-Seq_NSC_Mouse1.31936162
67NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.31435369
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31403293
69BP1_19119308_ChIP-ChIP_Hs578T_Human1.30828582
70MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30750382
71EZH2_27294783_Chip-Seq_NPCs_Mouse1.30305058
72SCL_19346495_ChIP-Seq_HPC-7_Human1.29772650
73TCF4_18268006_ChIP-ChIP_LS174T_Human1.29617497
74ARNT_22903824_ChIP-Seq_MCF-7_Human1.29087368
75BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.28016916
76ELK1_19687146_ChIP-ChIP_HELA_Human1.27763860
77SOX2_19829295_ChIP-Seq_ESCs_Human1.27407490
78NANOG_19829295_ChIP-Seq_ESCs_Human1.27407490
79TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27375558
80KDM2B_26808549_Chip-Seq_SUP-B15_Human1.26204068
81RBPJ_22232070_ChIP-Seq_NCS_Mouse1.26053257
82PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.25686047
83CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25435526
84TP63_19390658_ChIP-ChIP_HaCaT_Human1.25252297
85TP63_17297297_ChIP-ChIP_HaCaT_Human1.23555790
86TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23096462
87JARID2_20064375_ChIP-Seq_MESCs_Mouse1.22477365
88EZH2_27294783_Chip-Seq_ESCs_Mouse1.22097298
89SOX2_20726797_ChIP-Seq_SW620_Human1.21963008
90* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.20790629
91NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20254011
92SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.19832373
93SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19675973
94CDX2_20551321_ChIP-Seq_CACO-2_Human1.19547198
95CLOCK_20551151_ChIP-Seq_293T_Human1.19358253
96RNF2_27304074_Chip-Seq_ESCs_Mouse1.19027013
97SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17164499
98GATA3_21878914_ChIP-Seq_MCF-7_Human1.17138366
99FLI1_21867929_ChIP-Seq_TH2_Mouse1.17134309
100* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.16430011
101SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.16402737
102SMAD4_21741376_ChIP-Seq_EPCs_Human1.16379335
103DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.16212579
104PCGF2_27294783_Chip-Seq_ESCs_Mouse1.15115609
105RUNX_20019798_ChIP-Seq_JUKART_Human1.14810713
106ELK4_26923725_Chip-Seq_MESODERM_Mouse1.14667765
107ER_23166858_ChIP-Seq_MCF-7_Human1.13918933
108GATA1_19941826_ChIP-Seq_K562_Human1.13491287
109WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.13397443
110MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13287187
111SALL1_21062744_ChIP-ChIP_HESCs_Human1.12989356
112SMAD4_21799915_ChIP-Seq_A2780_Human1.12769141
113SMAD3_21741376_ChIP-Seq_HESCs_Human1.12068547
114SUZ12_27294783_Chip-Seq_ESCs_Mouse1.11864000
115* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.11712379
116TP53_16413492_ChIP-PET_HCT116_Human1.11677945
117KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.11503372
118KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.11503372
119KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.11503372
120SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.11174523
121SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.11174523
122STAT3_23295773_ChIP-Seq_U87_Human1.10343245
123MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09855589
124KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.08641226
125RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.08555562
126GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08361483
127CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.07957857
128RING1B_27294783_Chip-Seq_NPCs_Mouse1.06850822
129PIAS1_25552417_ChIP-Seq_VCAP_Human1.05476983
130TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.04965143
131EGR1_19374776_ChIP-ChIP_THP-1_Human1.04827555
132* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.04535569
133PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02367721
134CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01980530
135OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00437183
136ISL1_27105846_Chip-Seq_CPCs_Mouse1.00094828
137TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.99854528
138P300_19829295_ChIP-Seq_ESCs_Human0.99383223
139CDX2_22108803_ChIP-Seq_LS180_Human0.99276660
140SALL4_18804426_ChIP-ChIP_XEN_Mouse0.99266961
141NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.99133496
142NRF2_20460467_ChIP-Seq_MEFs_Mouse0.99133496
143* RING1B_27294783_Chip-Seq_ESCs_Mouse0.98230404
144* TP63_23658742_ChIP-Seq_EP156T_Human0.97805086
145ZNF263_19887448_ChIP-Seq_K562_Human0.96725848
146KDM2B_26808549_Chip-Seq_K562_Human0.96216813
147TAF15_26573619_Chip-Seq_HEK293_Human0.96172528
148RXR_22108803_ChIP-Seq_LS180_Human0.95987627
149NR3C1_23031785_ChIP-Seq_PC12_Mouse0.94891933
150KLF5_20875108_ChIP-Seq_MESCs_Mouse0.94779718
151VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.94563627
152* FOXA1_21572438_ChIP-Seq_LNCaP_Human0.94506645
153KDM2B_26808549_Chip-Seq_JURKAT_Human0.94429525
154RUNX2_22187159_ChIP-Seq_PCA_Human0.94270639
155RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.93656601
156TP53_22573176_ChIP-Seq_HFKS_Human0.93578091
157LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.92683497
158* SMAD4_21741376_ChIP-Seq_HESCs_Human0.91912472
159HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.91456454
160STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.90658124
161THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.90542747
162CRX_20693478_ChIP-Seq_RETINA_Mouse0.90003883
163FOXA1_27270436_Chip-Seq_PROSTATE_Human0.88859254
164FOXA1_25329375_ChIP-Seq_VCAP_Human0.88859254
165EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.88852809

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation7.33111321
2MP0005365_abnormal_bile_salt6.00727722
3MP0005167_abnormal_blood-brain_barrier5.37904323
4MP0005171_absent_coat_pigmentation4.71806390
5MP0004147_increased_porphyrin_level4.69141652
6MP0003724_increased_susceptibility_to4.14844625
7MP0000465_gastrointestinal_hemorrhage4.08878090
8MP0001879_abnormal_lymphatic_vessel3.71511188
9MP0009278_abnormal_bone_marrow3.57664988
10MP0010234_abnormal_vibrissa_follicle3.36943231
11MP0003195_calcinosis3.26024865
12MP0001188_hyperpigmentation3.12746399
13MP0010368_abnormal_lymphatic_system2.67653819
14MP0005397_hematopoietic_system_phenotyp2.55560717
15MP0001545_abnormal_hematopoietic_system2.55560717
16MP0003303_peritoneal_inflammation2.49171370
17MP0005623_abnormal_meninges_morphology2.48548983
18MP0008995_early_reproductive_senescence2.45197820
19MP0009697_abnormal_copulation2.42878868
20MP0004272_abnormal_basement_membrane2.39104263
21MP0002127_abnormal_cardiovascular_syste2.35886853
22MP0000767_abnormal_smooth_muscle2.25013312
23MP0003828_pulmonary_edema2.19835326
24MP0006035_abnormal_mitochondrial_morpho2.12649293
25MP0000372_irregular_coat_pigmentation2.03245911
26MP0005084_abnormal_gallbladder_morpholo1.94626068
27MP0004043_abnormal_pH_regulation1.89630809
28MP0006054_spinal_hemorrhage1.89163309
29MP0005367_renal/urinary_system_phenotyp1.88216810
30MP0000516_abnormal_urinary_system1.88216810
31MP0003300_gastrointestinal_ulcer1.84882313
32MP0004084_abnormal_cardiac_muscle1.82148775
33MP0002638_abnormal_pupillary_reflex1.80478647
34MP0004885_abnormal_endolymph1.77108022
35MP0009672_abnormal_birth_weight1.75185011
36MP0002295_abnormal_pulmonary_circulatio1.73560422
37MP0001756_abnormal_urination1.66161030
38MP0010352_gastrointestinal_tract_polyps1.64631023
39MP0005187_abnormal_penis_morphology1.64346893
40MP0004215_abnormal_myocardial_fiber1.55866346
41MP0001346_abnormal_lacrimal_gland1.53172237
42MP0005165_increased_susceptibility_to1.50731219
43MP0005408_hypopigmentation1.49266283
44MP0010678_abnormal_skin_adnexa1.47578010
45MP0002138_abnormal_hepatobiliary_system1.46182868
46MP0000249_abnormal_blood_vessel1.43988102
47MP0004782_abnormal_surfactant_physiolog1.35628825
48MP0001873_stomach_inflammation1.33979398
49MP0002166_altered_tumor_susceptibility1.33913536
50MP0004883_abnormal_blood_vessel1.32614075
51MP0005595_abnormal_vascular_smooth1.31670193
52MP0005448_abnormal_energy_balance1.27745117
53MP0003091_abnormal_cell_migration1.26098678
54MP0009333_abnormal_splenocyte_physiolog1.22959599
55MP0009053_abnormal_anal_canal1.20382135
56MP0009780_abnormal_chondrocyte_physiolo1.19069716
57MP0002972_abnormal_cardiac_muscle1.15636379
58MP0003646_muscle_fatigue1.14096353
59MP0002128_abnormal_blood_circulation1.13907597
60MP0003950_abnormal_plasma_membrane1.10972097
61MP0003385_abnormal_body_wall1.10820252
62MP0003119_abnormal_digestive_system1.08827908
63MP0009765_abnormal_xenobiotic_induced1.08622035
64MP0002925_abnormal_cardiovascular_devel1.07941803
65MP0003315_abnormal_perineum_morphology1.07780998
66MP0004036_abnormal_muscle_relaxation1.07033129
67MP0002933_joint_inflammation1.03953215
68MP0006138_congestive_heart_failure1.01737039
69MP0002928_abnormal_bile_duct1.01179826
70MP0003279_aneurysm1.00266306
71MP0002254_reproductive_system_inflammat0.99586476
72MP0001727_abnormal_embryo_implantation0.98799910
73MP0005647_abnormal_sex_gland0.98698318
74MP0000467_abnormal_esophagus_morphology0.98466291
75MP0000015_abnormal_ear_pigmentation0.97815429
76MP0000733_abnormal_muscle_development0.97221843
77MP0008877_abnormal_DNA_methylation0.96679414
78MP0003705_abnormal_hypodermis_morpholog0.96565292
79MP0001614_abnormal_blood_vessel0.93268149
80MP0003943_abnormal_hepatobiliary_system0.92679153
81MP0010630_abnormal_cardiac_muscle0.92568014
82MP0002332_abnormal_exercise_endurance0.92307849
83MP0001944_abnormal_pancreas_morphology0.91957542
84MP0000681_abnormal_thyroid_gland0.90597932
85MP0008438_abnormal_cutaneous_collagen0.90431272
86MP0005334_abnormal_fat_pad0.89669872
87MP0003453_abnormal_keratinocyte_physiol0.89249618
88MP0003567_abnormal_fetal_cardiomyocyte0.86980548
89MP0001119_abnormal_female_reproductive0.86482915
90MP0005620_abnormal_muscle_contractility0.85185529
91MP0005551_abnormal_eye_electrophysiolog0.85069716
92MP0000383_abnormal_hair_follicle0.84266912
93MP0000358_abnormal_cell_content/0.82370447
94MP0001661_extended_life_span0.82029271
95MP0001915_intracranial_hemorrhage0.78742740
96MP0006072_abnormal_retinal_apoptosis0.78677855
97MP0000003_abnormal_adipose_tissue0.78072930
98MP0009785_altered_susceptibility_to0.77571027
99MP0000462_abnormal_digestive_system0.75805335
100MP0000537_abnormal_urethra_morphology0.75690969
101MP0001849_ear_inflammation0.74979539
102MP0002006_tumorigenesis0.74043042
103MP0002796_impaired_skin_barrier0.69903927
104MP0002693_abnormal_pancreas_physiology0.68690840
105MP0001784_abnormal_fluid_regulation0.68282368
106MP0001919_abnormal_reproductive_system0.67915899
107MP0009703_decreased_birth_body0.67759146
108MP0003566_abnormal_cell_adhesion0.67120405
109MP0002938_white_spotting0.66751594
110MP0000427_abnormal_hair_cycle0.65997836
111MP0008775_abnormal_heart_ventricle0.65161827
112MP0009764_decreased_sensitivity_to0.64661571
113* MP0005410_abnormal_fertilization0.64564011
114MP0005253_abnormal_eye_physiology0.61437687
115MP0001905_abnormal_dopamine_level0.60589742
116MP0005164_abnormal_response_to0.59124088
117MP0008875_abnormal_xenobiotic_pharmacok0.58762899
118MP0002088_abnormal_embryonic_growth/wei0.58717850
119MP0000266_abnormal_heart_morphology0.57303925
120MP0002653_abnormal_ependyma_morphology0.57159781
121MP0002098_abnormal_vibrissa_morphology0.57098409
122MP0001486_abnormal_startle_reflex0.55763555
123MP0005409_darkened_coat_color0.55692707
124MP0002282_abnormal_trachea_morphology0.55428878
125MP0000762_abnormal_tongue_morphology0.55189409
126* MP0001929_abnormal_gametogenesis0.54275349
127MP0004484_altered_response_of0.53179159
128MP0003868_abnormal_feces_composition0.52871722
129MP0004808_abnormal_hematopoietic_stem0.52745192
130MP0002896_abnormal_bone_mineralization0.52569234
131MP0001533_abnormal_skeleton_physiology0.50860750
132MP0004085_abnormal_heartbeat0.50837916
133MP0004019_abnormal_vitamin_homeostasis0.50481680
134MP0000653_abnormal_sex_gland0.50275191
135MP0001145_abnormal_male_reproductive0.50005905
136MP0005220_abnormal_exocrine_pancreas0.49906485
137MP0001851_eye_inflammation0.48570799
138MP0005389_reproductive_system_phenotype0.47685081
139MP0003137_abnormal_impulse_conducting0.47028994
140MP0005670_abnormal_white_adipose0.46213368
141MP0009643_abnormal_urine_homeostasis0.46147755
142MP0001958_emphysema0.46126771
143MP0003638_abnormal_response/metabolism_0.45956532
144MP0005166_decreased_susceptibility_to0.45812774
145MP0003633_abnormal_nervous_system0.45228024
146MP0002837_dystrophic_cardiac_calcinosis0.44856466
147MP0005319_abnormal_enzyme/_coenzyme0.44707632
148MP0003941_abnormal_skin_development0.44407146
149MP0001544_abnormal_cardiovascular_syste0.44199308
150MP0005385_cardiovascular_system_phenoty0.44199308
151MP0002136_abnormal_kidney_physiology0.44109283
152MP0003984_embryonic_growth_retardation0.43844794
153MP0002822_catalepsy0.43542454
154MP0002086_abnormal_extraembryonic_tissu0.43494445
155MP0000343_altered_response_to0.42233082
156MP0003011_delayed_dark_adaptation0.41436533
157MP0000230_abnormal_systemic_arterial0.39942846
158MP0008874_decreased_physiological_sensi0.39593105
159MP0002084_abnormal_developmental_patter0.39170889
160MP0005330_cardiomyopathy0.38560083
161MP0002168_other_aberrant_phenotype0.36967193

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)9.59010241
2Hypoglycemic coma (HP:0001325)9.17053872
3Thick nail (HP:0001805)8.07814720
4Elfin facies (HP:0004428)8.04253627
5Symptomatic seizures (HP:0011145)7.95672725
6Reduced subcutaneous adipose tissue (HP:0003758)7.30935065
7Asymmetry of the thorax (HP:0001555)7.00872071
8Abnormality of the pancreatic islet cells (HP:0006476)6.36358936
9Abnormality of endocrine pancreas physiology (HP:0012093)6.36358936
10Insulin-resistant diabetes mellitus (HP:0000831)6.29617411
11Ketoacidosis (HP:0001993)6.07193793
12Growth hormone excess (HP:0000845)5.74477310
13Hematochezia (HP:0002573)5.17583172
14Hyperglycemia (HP:0003074)4.94643422
15Congenital, generalized hypertrichosis (HP:0004540)4.57749098
16Aqueductal stenosis (HP:0002410)4.49866097
17Enlarged penis (HP:0000040)4.29357461
18Distal lower limb muscle weakness (HP:0009053)4.21027254
19Neoplasm of the adrenal cortex (HP:0100641)3.79441464
20Lymphangioma (HP:0100764)3.77280124
21Advanced eruption of teeth (HP:0006288)3.76091430
22Large hands (HP:0001176)3.75613402
23Increased connective tissue (HP:0009025)3.74339544
24Fused cervical vertebrae (HP:0002949)3.67722277
25Stenosis of the external auditory canal (HP:0000402)3.63843213
26Absent hand (HP:0004050)3.62837089
27J-shaped sella turcica (HP:0002680)3.62573214
28Pigmentary retinal degeneration (HP:0001146)3.60936261
29Ketosis (HP:0001946)3.56727447
30Clitoromegaly (HP:0000057)3.56361536
31Buphthalmos (HP:0000557)3.55117696
32Visceral angiomatosis (HP:0100761)3.52398213
33Thickened helices (HP:0000391)3.49021959
34Muscle fiber splitting (HP:0003555)3.28077602
35Hypoplasia of the capital femoral epiphysis (HP:0003090)3.23985254
36Conjunctival hamartoma (HP:0100780)3.22131784
37Wrist flexion contracture (HP:0001239)3.19562137
38Hemangiomatosis (HP:0007461)3.14978452
39Tubular atrophy (HP:0000092)3.10685183
40Round ear (HP:0100830)3.06818948
41Mitral stenosis (HP:0001718)2.99356234
42Esophageal varix (HP:0002040)2.97080896
43Abnormality of skeletal muscle fiber size (HP:0012084)2.89037262
44Cupped ear (HP:0000378)2.84684892
45Insulin resistance (HP:0000855)2.83607666
46Aplasia involving bones of the extremities (HP:0009825)2.75777406
47Aplasia involving bones of the upper limbs (HP:0009823)2.75777406
48Aplasia of the phalanges of the hand (HP:0009802)2.75777406
49Broad metatarsal (HP:0001783)2.73304217
50Distal lower limb amyotrophy (HP:0008944)2.68272574
51Parakeratosis (HP:0001036)2.64988960
52Acanthosis nigricans (HP:0000956)2.62526356
53Accelerated skeletal maturation (HP:0005616)2.58383609
54Short hallux (HP:0010109)2.54992180
55Adactyly (HP:0009776)2.52738498
56Absent epiphyses (HP:0010577)2.51837275
57Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.51837275
58Thickened nuchal skin fold (HP:0000474)2.51289643
59Abnormality of secondary sexual hair (HP:0009888)2.50867181
60Abnormality of the axillary hair (HP:0100134)2.50867181
61Heterochromia iridis (HP:0001100)2.50348543
62Hyperpituitarism (HP:0010514)2.49485136
63Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.47348844
64Vertebral hypoplasia (HP:0008417)2.47348844
65Atrioventricular block (HP:0001678)2.47111577
66Macroorchidism (HP:0000053)2.46765580
67Generalized hyperpigmentation (HP:0007440)2.46410895
68Portal hypertension (HP:0001409)2.45629930
69Nemaline bodies (HP:0003798)2.41443192
70Cutaneous melanoma (HP:0012056)2.41030876
71Difficulty running (HP:0009046)2.39512718
72Premature rupture of membranes (HP:0001788)2.38504506
73Hyporeflexia of lower limbs (HP:0002600)2.38272371
74Spinal rigidity (HP:0003306)2.37886275
75Hyperventilation (HP:0002883)2.35616775
76Bronchomalacia (HP:0002780)2.34036919
77Chin dimple (HP:0010751)2.30757199
78Abnormality of the clitoris (HP:0000056)2.30561442
79Female pseudohermaphroditism (HP:0010458)2.28106470
80Lower limb amyotrophy (HP:0007210)2.27757486
81Cutaneous finger syndactyly (HP:0010554)2.27013616
82Thyroiditis (HP:0100646)2.24747774
83Amblyopia (HP:0000646)2.24088046
84Centrally nucleated skeletal muscle fibers (HP:0003687)2.22527413
85Coarse hair (HP:0002208)2.20675687
86Abnormality of the hepatic vasculature (HP:0006707)2.19692873
87Short humerus (HP:0005792)2.18674210
88Aplasia/Hypoplasia of the hallux (HP:0008362)2.17282660
89Cerebral hemorrhage (HP:0001342)2.11348458
90Hemorrhage of the eye (HP:0011885)2.07099165
91Testicular neoplasm (HP:0010788)2.05228008
92Bulbar palsy (HP:0001283)2.04914691
93Supernumerary nipples (HP:0002558)2.04101937
94EMG: myopathic abnormalities (HP:0003458)2.02963577
95Skull defect (HP:0001362)2.01729698
96Difficulty climbing stairs (HP:0003551)2.00731718
97Abdominal distention (HP:0003270)2.00672999
98Hypoglycemic seizures (HP:0002173)11.9155141
99Pancreatic islet-cell hyperplasia (HP:0004510)10.5850603
100Long foot (HP:0001833)10.1818862
101Follicular hyperkeratosis (HP:0007502)1.99937946
102Cutis marmorata (HP:0000965)1.99770062
103Hyperthyroidism (HP:0000836)1.98475736
104Absent toe (HP:0010760)1.96344268
105Submucous cleft hard palate (HP:0000176)1.95135541
106Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.94900849
107Transitional cell carcinoma of the bladder (HP:0006740)1.93504057
108Long nose (HP:0003189)1.92852627
109Facial diplegia (HP:0001349)1.92313953
110Increased variability in muscle fiber diameter (HP:0003557)1.91462649
111Aplasia/hypoplasia of the humerus (HP:0006507)1.91378894
112Arterial tortuosity (HP:0005116)1.91329411
113Progressive cerebellar ataxia (HP:0002073)1.90647295
114Hamartoma of the eye (HP:0010568)1.89038806
115Delayed CNS myelination (HP:0002188)1.88842020
116Distal arthrogryposis (HP:0005684)1.88486824
117Intention tremor (HP:0002080)1.86109114
118Shallow orbits (HP:0000586)1.85509234
119Abnormality of cells of the erythroid lineage (HP:0012130)1.83720357
120Aortic valve stenosis (HP:0001650)1.83608132
121Spontaneous hematomas (HP:0007420)1.83276186
122Focal segmental glomerulosclerosis (HP:0000097)1.83100297
123Thoracolumbar scoliosis (HP:0002944)1.81891482
124Cerebral aneurysm (HP:0004944)1.80545837
125Cutaneous syndactyly (HP:0012725)1.80455846
126Alopecia of scalp (HP:0002293)1.80055061
127Polycythemia (HP:0001901)1.79036026
128Limb-girdle muscle atrophy (HP:0003797)1.77969906
129Bladder carcinoma (HP:0002862)1.76416087
130Bladder neoplasm (HP:0009725)1.76416087
131Gynecomastia (HP:0000771)1.76327278
132Absent radius (HP:0003974)1.72597654
133Porencephaly (HP:0002132)1.70614597
134Muscle fiber inclusion bodies (HP:0100299)1.70366720
135Pancreatic cysts (HP:0001737)1.65429913
136Gingival overgrowth (HP:0000212)1.61002930
137Heart block (HP:0012722)1.60007673
138Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)1.56817747
1393-Methylglutaconic aciduria (HP:0003535)1.55279690
140True hermaphroditism (HP:0010459)1.52440712
141Occipital encephalocele (HP:0002085)1.48320247
142Ectopic kidney (HP:0000086)1.46508979
143Disproportionate short-trunk short stature (HP:0003521)1.46308308
144Polydipsia (HP:0001959)1.42620510
145Abnormal drinking behavior (HP:0030082)1.42620510
146Tubulointerstitial nephritis (HP:0001970)1.40744123
147Scotoma (HP:0000575)1.39932530
148Abnormal atrioventricular conduction (HP:0005150)1.36832955
149Pancreatic fibrosis (HP:0100732)1.36593742
150Myocardial infarction (HP:0001658)1.34985059
151Methylmalonic acidemia (HP:0002912)1.33770980
152Polycystic ovaries (HP:0000147)1.32552309
153Keratoconus (HP:0000563)1.31823311
154Increased corneal curvature (HP:0100692)1.31823311
155Atrial fibrillation (HP:0005110)1.31486889
156Abnormality of the renal medulla (HP:0100957)1.30817457
157Lipoatrophy (HP:0100578)1.25119759
158Small for gestational age (HP:0001518)1.23888622
159Precocious puberty (HP:0000826)1.23039654
160Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.22194164
161Stomach cancer (HP:0012126)1.22114115
162Nonimmune hydrops fetalis (HP:0001790)1.22031542
163Nephronophthisis (HP:0000090)1.21776099
164Leiomyosarcoma (HP:0100243)1.21131582
165Uterine leiomyosarcoma (HP:0002891)1.21131582
166Postnatal growth retardation (HP:0008897)1.19574480
167Supraventricular arrhythmia (HP:0005115)1.18008969
168Wide mouth (HP:0000154)1.17382433
169Hemiparesis (HP:0001269)1.16331752
170Type II diabetes mellitus (HP:0005978)1.16240434
171Abnormality of the renal cortex (HP:0011035)1.16002616
172Primary atrial arrhythmia (HP:0001692)1.14581701
173Congenital hepatic fibrosis (HP:0002612)1.14128518
174Supraventricular tachycardia (HP:0004755)1.10424956
175Fatigue (HP:0012378)1.09872989
176Polyuria (HP:0000103)1.07724664
177Widely spaced teeth (HP:0000687)1.06691428
178Abnormality of dental color (HP:0011073)1.05728251
179Progressive inability to walk (HP:0002505)1.05473765
180Attenuation of retinal blood vessels (HP:0007843)1.05215205
181Absent eyebrow (HP:0002223)1.03545750
182Polyphagia (HP:0002591)1.02601789
183Molar tooth sign on MRI (HP:0002419)0.98654605
184Abnormality of midbrain morphology (HP:0002418)0.98654605
185Absent speech (HP:0001344)0.98420899
186Inability to walk (HP:0002540)0.98207886

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR27.49270089
2FRK7.16710674
3IRAK33.79042739
4TIE13.35470084
5PTK2B3.34150320
6MAPK73.08601362
7MAPK122.85806776
8KDR2.70031481
9CLK12.65527236
10FGFR32.32817203
11PRKG22.16668466
12MAP4K22.02639372
13CAMK1D1.99231655
14PDK21.86810529
15INSRR1.77091233
16CAMK1G1.68890393
17WNK41.68383785
18MAP3K121.62292171
19ITK1.46552574
20TGFBR21.46339708
21NUAK11.41543493
22STK31.35333173
23PLK21.34200470
24PLK31.24502636
25BMPR1B1.16576585
26WNK11.13099193
27GRK11.05052472
28MYLK1.04727423
29PTK60.98451254
30DMPK0.97208643
31TSSK60.96984411
32PRKAA20.96399672
33PAK20.95208530
34ACVR1B0.91128733
35TAF10.89954121
36CASK0.89402131
37EPHB20.85040546
38ADRBK20.79607964
39WNK30.78561722
40PDGFRB0.77161207
41TESK10.74630335
42MAP3K140.73386633
43TGFBR10.72118310
44ABL20.70796291
45ROCK10.69730275
46AKT30.67515643
47PINK10.66455394
48SRPK10.65859306
49PDGFRA0.65630156
50MAP3K30.65591276
51FGR0.64938180
52MAP2K30.60612652
53FER0.60019001
54TTK0.59226504
55CAMK2B0.58721628
56MATK0.57524429
57BRD40.55052789
58EPHA20.54673674
59INSR0.53342573
60NEK60.53221148
61CSNK1A1L0.51822853
62MINK10.51212890
63LIMK10.50497658
64STK40.48978923
65LRRK20.48084603
66PIK3CG0.46726203
67TTN0.46444185
68STK390.45335688
69PAK30.42451282
70NLK0.42219551
71DDR20.42066907
72ILK0.41056923
73SRC0.40293252
74FLT30.38611566
75STK110.38101825
76PNCK0.37836702
77MTOR0.37515091
78MAPK40.37328178
79CSNK1G30.36714690
80CSK0.36267871
81CSNK1G10.35387543
82VRK20.35215390
83PIM20.34293153
84ZAK0.33457555
85MAPK150.32722467
86CDK50.31350219
87CAMK2A0.30255871
88HCK0.30240332
89IGF1R0.30219987
90ADRBK10.30161462
91PRKAA10.29626425
92MAPK130.29614757
93CSNK1G20.29567783
94ROCK20.28554740
95CDK140.28163179
96LYN0.28110881
97PRKCE0.27433551
98BRSK20.27408244
99MET0.27024477
100CDK80.26527928
101GRK50.25265546
102ABL10.23893717
103PRKCQ0.23643833
104PRKCZ0.23084295
105PTK20.22145895
106CAMKK20.22142849
107MST40.21629259
108VRK10.21336203
109MAP2K10.19744842
110PRKCD0.19375478
111PRPF4B0.19294162
112DAPK30.19026466
113MAPK80.18540285
114ERBB30.18464822
115PRKACG0.17803142
116MAP2K70.16849734
117ZAP700.16808119
118MKNK20.16769492
119TRIM280.16120270
120MAP4K10.16048910
121FGFR10.15686189
122NTRK10.14815894
123ERBB40.14590352
124PAK40.14475704
125PRKCA0.14354020
126LCK0.12869248
127OXSR10.12790562
128TXK0.12134858
129MAP3K110.12084962
130TLK10.12046989
131RPS6KA30.11902681
132PRKD10.11614477
133CAMK10.11495279
134FGFR40.11358304
135CDK90.10664406
136PIK3CA0.10326410
137FES0.10029834
138CSNK1A10.08619094
139NEK20.07168529
140NEK90.06687535
141DAPK20.06533717
142GRK60.06341046
143PRKACA0.05329767
144JAK30.04502267
145PHKG10.04467566
146PHKG20.04467566
147MAPKAPK30.04194803
148IKBKB0.04191039
149PRKCI0.03293370
150LATS20.03265622
151CSNK1D0.03052812
152SGK20.02689133
153YES10.02516405
154DAPK10.02375394
155PRKG10.01817501
156PRKCG0.01780164
157EIF2AK10.01618894
158STK100.01408439

Predicted pathways (KEGG)

RankGene SetZ-score
1Ovarian steroidogenesis_Homo sapiens_hsa049134.15691985
2Arginine biosynthesis_Homo sapiens_hsa002203.74983881
3Viral myocarditis_Homo sapiens_hsa054163.35253977
4Regulation of lipolysis in adipocytes_Homo sapiens_hsa049233.23901715
5Type II diabetes mellitus_Homo sapiens_hsa049303.08508809
6Dorso-ventral axis formation_Homo sapiens_hsa043202.44480077
7Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.44224704
8Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.16483675
9Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.13712959
10Axon guidance_Homo sapiens_hsa043602.11609483
11Longevity regulating pathway - multiple species_Homo sapiens_hsa042132.06945819
12Prion diseases_Homo sapiens_hsa050201.95354298
13Focal adhesion_Homo sapiens_hsa045101.94796907
14Adherens junction_Homo sapiens_hsa045201.94763334
15Leukocyte transendothelial migration_Homo sapiens_hsa046701.94112183
16Dilated cardiomyopathy_Homo sapiens_hsa054141.91109374
17ECM-receptor interaction_Homo sapiens_hsa045121.74656778
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.72212591
19Longevity regulating pathway - mammal_Homo sapiens_hsa042111.70777571
20Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.70017098
21Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.68896116
22Propanoate metabolism_Homo sapiens_hsa006401.67985862
23Ras signaling pathway_Homo sapiens_hsa040141.67854313
24Tight junction_Homo sapiens_hsa045301.66022897
25Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.55119980
26GABAergic synapse_Homo sapiens_hsa047271.51246554
27Chemical carcinogenesis_Homo sapiens_hsa052041.50503022
28Glycosaminoglycan degradation_Homo sapiens_hsa005311.46870581
29Platelet activation_Homo sapiens_hsa046111.46610889
30Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.45568312
31FoxO signaling pathway_Homo sapiens_hsa040681.43986693
32Rap1 signaling pathway_Homo sapiens_hsa040151.43066044
33Linoleic acid metabolism_Homo sapiens_hsa005911.41200201
34Protein export_Homo sapiens_hsa030601.41176214
35Ether lipid metabolism_Homo sapiens_hsa005651.40679374
36Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.39945237
37AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.37973916
38Phototransduction_Homo sapiens_hsa047441.37362308
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.35260070
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.34572790
41Renal cell carcinoma_Homo sapiens_hsa052111.29969144
42PI3K-Akt signaling pathway_Homo sapiens_hsa041511.29026607
43Estrogen signaling pathway_Homo sapiens_hsa049151.23017071
44Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.21381012
45Glutamatergic synapse_Homo sapiens_hsa047241.17663467
46Arginine and proline metabolism_Homo sapiens_hsa003301.15164935
47Morphine addiction_Homo sapiens_hsa050321.12782477
48VEGF signaling pathway_Homo sapiens_hsa043701.09980438
49Complement and coagulation cascades_Homo sapiens_hsa046101.09771197
50Gap junction_Homo sapiens_hsa045401.08610337
51Prostate cancer_Homo sapiens_hsa052151.07631245
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.07330645
53Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.06233866
54Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.04552484
55Basal transcription factors_Homo sapiens_hsa030221.03767392
56Pathways in cancer_Homo sapiens_hsa052001.03590209
57HIF-1 signaling pathway_Homo sapiens_hsa040661.03567654
58African trypanosomiasis_Homo sapiens_hsa051431.02771527
59Oxytocin signaling pathway_Homo sapiens_hsa049211.02346245
60Long-term depression_Homo sapiens_hsa047301.01860278
61Nitrogen metabolism_Homo sapiens_hsa009101.01632309
62GnRH signaling pathway_Homo sapiens_hsa049121.00882014
63Circadian rhythm_Homo sapiens_hsa047101.00617226
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.99386251
65Aldosterone synthesis and secretion_Homo sapiens_hsa049250.97745718
66cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97208704
67Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.96935568
68Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.96699790
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.95619559
70ABC transporters_Homo sapiens_hsa020100.95350561
71Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.94433827
72Tryptophan metabolism_Homo sapiens_hsa003800.93743282
73Bile secretion_Homo sapiens_hsa049760.93498870
74NF-kappa B signaling pathway_Homo sapiens_hsa040640.93404804
75Cholinergic synapse_Homo sapiens_hsa047250.90950740
76Small cell lung cancer_Homo sapiens_hsa052220.90743428
77Regulation of actin cytoskeleton_Homo sapiens_hsa048100.89149714
78Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.89057330
79Circadian entrainment_Homo sapiens_hsa047130.87837516
80Serotonergic synapse_Homo sapiens_hsa047260.87766079
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.86684923
82Glioma_Homo sapiens_hsa052140.85767095
83MicroRNAs in cancer_Homo sapiens_hsa052060.85573115
84Hippo signaling pathway_Homo sapiens_hsa043900.82577024
85Melanogenesis_Homo sapiens_hsa049160.80371027
86Dopaminergic synapse_Homo sapiens_hsa047280.79997612
87Proteoglycans in cancer_Homo sapiens_hsa052050.78817383
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.78433522
89Caffeine metabolism_Homo sapiens_hsa002320.78389818
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.78015543
91Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.77631978
92Alzheimers disease_Homo sapiens_hsa050100.77209001
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76897985
94Amoebiasis_Homo sapiens_hsa051460.76062100
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75830089
96Shigellosis_Homo sapiens_hsa051310.75564906
97Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74203883
98Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.73863760
99Glycerolipid metabolism_Homo sapiens_hsa005610.73167146
100Regulation of autophagy_Homo sapiens_hsa041400.72346515
101ErbB signaling pathway_Homo sapiens_hsa040120.70828363
102Pertussis_Homo sapiens_hsa051330.70244396
103Notch signaling pathway_Homo sapiens_hsa043300.68997309
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.68444165
105Gastric acid secretion_Homo sapiens_hsa049710.67035343
106Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66830309
107Proteasome_Homo sapiens_hsa030500.66726371
108PPAR signaling pathway_Homo sapiens_hsa033200.66107000
109Vascular smooth muscle contraction_Homo sapiens_hsa042700.65606750
110Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64622448
111Salivary secretion_Homo sapiens_hsa049700.64181280
112Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63808810
113TGF-beta signaling pathway_Homo sapiens_hsa043500.63010540
114MAPK signaling pathway_Homo sapiens_hsa040100.61513797
115Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61006768
116Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.60868892
117Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60685699
118Cardiac muscle contraction_Homo sapiens_hsa042600.60629566
119Basal cell carcinoma_Homo sapiens_hsa052170.60524620
120Fatty acid elongation_Homo sapiens_hsa000620.59567582
121Renin secretion_Homo sapiens_hsa049240.59078860
122Intestinal immune network for IgA production_Homo sapiens_hsa046720.58676200
123Long-term potentiation_Homo sapiens_hsa047200.58663892
124AMPK signaling pathway_Homo sapiens_hsa041520.58300509
125Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58111729
126Insulin secretion_Homo sapiens_hsa049110.58107831
127Thyroid hormone synthesis_Homo sapiens_hsa049180.57770582
128Calcium signaling pathway_Homo sapiens_hsa040200.57177872
129Melanoma_Homo sapiens_hsa052180.56191111
130Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54729101
131Amphetamine addiction_Homo sapiens_hsa050310.53583829
132Insulin resistance_Homo sapiens_hsa049310.53053703
133Insulin signaling pathway_Homo sapiens_hsa049100.52488031
134Vitamin digestion and absorption_Homo sapiens_hsa049770.52098504
135Homologous recombination_Homo sapiens_hsa034400.51877052
136Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.51264336
137Protein digestion and absorption_Homo sapiens_hsa049740.50905580
138Hepatitis B_Homo sapiens_hsa051610.50274653
139Staphylococcus aureus infection_Homo sapiens_hsa051500.50055675
140Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.49324934
141HTLV-I infection_Homo sapiens_hsa051660.48986630
142RNA degradation_Homo sapiens_hsa030180.47832307
143Toxoplasmosis_Homo sapiens_hsa051450.47488685
144Hedgehog signaling pathway_Homo sapiens_hsa043400.46155356
145Wnt signaling pathway_Homo sapiens_hsa043100.45962606
146Phospholipase D signaling pathway_Homo sapiens_hsa040720.44884238
147Cocaine addiction_Homo sapiens_hsa050300.43693994
148Pancreatic secretion_Homo sapiens_hsa049720.43100753
149Butanoate metabolism_Homo sapiens_hsa006500.42128863
150Peroxisome_Homo sapiens_hsa041460.41222860
151Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39209233
152Steroid biosynthesis_Homo sapiens_hsa001000.39099828
153Selenocompound metabolism_Homo sapiens_hsa004500.38297146
154Taste transduction_Homo sapiens_hsa047420.38170602
155Steroid hormone biosynthesis_Homo sapiens_hsa001400.37260636
156Rheumatoid arthritis_Homo sapiens_hsa053230.36574240
157Primary bile acid biosynthesis_Homo sapiens_hsa001200.35908292
158Nicotine addiction_Homo sapiens_hsa050330.35752198
159Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.27245831
160cAMP signaling pathway_Homo sapiens_hsa040240.27208539
161Fanconi anemia pathway_Homo sapiens_hsa034600.25076547

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