PRNP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)5.50015489
2regulation of short-term neuronal synaptic plasticity (GO:0048172)4.68474550
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.33631945
4synaptic vesicle exocytosis (GO:0016079)4.28808137
5vocalization behavior (GO:0071625)4.19087080
6ionotropic glutamate receptor signaling pathway (GO:0035235)4.15709552
7neuronal action potential propagation (GO:0019227)4.12373931
8locomotory exploration behavior (GO:0035641)4.04460491
9synaptic vesicle maturation (GO:0016188)4.04430236
10neuron cell-cell adhesion (GO:0007158)4.04148108
11regulation of synaptic vesicle exocytosis (GO:2000300)4.01263021
12positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.00356692
13amino acid import (GO:0043090)3.97402923
14glutamate receptor signaling pathway (GO:0007215)3.96488629
15glutamate secretion (GO:0014047)3.94764108
16regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.94216840
17cellular potassium ion homeostasis (GO:0030007)3.91504340
18cerebellar granule cell differentiation (GO:0021707)3.86527600
19protein localization to synapse (GO:0035418)3.82437519
20cytoskeletal anchoring at plasma membrane (GO:0007016)3.82264000
21gamma-aminobutyric acid signaling pathway (GO:0007214)3.66438956
22regulation of glutamate receptor signaling pathway (GO:1900449)3.64762560
23regulation of neuronal synaptic plasticity (GO:0048168)3.64415584
24regulation of long-term neuronal synaptic plasticity (GO:0048169)3.62278205
25protein localization to endosome (GO:0036010)3.61458443
26neuron recognition (GO:0008038)3.59099331
27regulation of synaptic vesicle transport (GO:1902803)3.58231866
28synaptic transmission, glutamatergic (GO:0035249)3.53408310
29neuron-neuron synaptic transmission (GO:0007270)3.48590751
30exploration behavior (GO:0035640)3.48351239
31cell adhesion mediated by integrin (GO:0033627)3.44399348
32regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.39470233
33long-term synaptic potentiation (GO:0060291)3.31967266
34negative regulation of synaptic transmission, GABAergic (GO:0032229)3.31444447
35transmission of nerve impulse (GO:0019226)3.29025493
36neurotransmitter secretion (GO:0007269)3.24941816
37membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.24547029
38sodium ion export (GO:0071436)3.24452043
39positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.23974915
40axonal fasciculation (GO:0007413)3.22611269
41regulation of excitatory postsynaptic membrane potential (GO:0060079)3.19754888
42presynaptic membrane assembly (GO:0097105)3.19069795
43long-term memory (GO:0007616)3.18780763
44regulation of vesicle fusion (GO:0031338)3.17636584
45gamma-aminobutyric acid transport (GO:0015812)3.16914175
46layer formation in cerebral cortex (GO:0021819)3.16566437
47dendritic spine morphogenesis (GO:0060997)3.16115089
48G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.13031381
49neurotransmitter-gated ion channel clustering (GO:0072578)3.11634163
50neuromuscular process controlling balance (GO:0050885)3.11285882
51regulation of ARF protein signal transduction (GO:0032012)3.11128275
52regulation of synaptic plasticity (GO:0048167)3.10506810
53proline transport (GO:0015824)3.10248329
54cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.09963218
55negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.08002391
56cell communication by electrical coupling (GO:0010644)3.06352729
57regulation of postsynaptic membrane potential (GO:0060078)3.06271754
58regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.06192851
59presynaptic membrane organization (GO:0097090)3.05777323
60detection of calcium ion (GO:0005513)3.05042128
61synaptic vesicle endocytosis (GO:0048488)3.04934609
62response to histamine (GO:0034776)3.03927328
63response to gravity (GO:0009629)3.03746943
64negative regulation of dendrite morphogenesis (GO:0050774)3.03429262
65synaptic vesicle docking involved in exocytosis (GO:0016081)3.01316280
66cell-substrate junction assembly (GO:0007044)3.00100702
67cell communication involved in cardiac conduction (GO:0086065)2.98682825
68innervation (GO:0060384)2.98023391
69regulation of dendritic spine morphogenesis (GO:0061001)2.97510494
70neuronal ion channel clustering (GO:0045161)2.96795671
71neurotransmitter transport (GO:0006836)2.96359108
72regulation of amyloid precursor protein catabolic process (GO:1902991)2.93952263
73regulation of synaptic transmission, glutamatergic (GO:0051966)2.91759606
74regulation of synapse structural plasticity (GO:0051823)2.91008229
75cerebellar Purkinje cell layer development (GO:0021680)2.88862185
76central nervous system myelination (GO:0022010)2.85838308
77axon ensheathment in central nervous system (GO:0032291)2.85838308
78negative regulation of neurotransmitter transport (GO:0051589)2.84287834
79G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.84236705
80postsynaptic membrane organization (GO:0001941)2.83643579
81positive regulation of membrane potential (GO:0045838)2.81366323
82long term synaptic depression (GO:0060292)2.80986042
83L-amino acid import (GO:0043092)2.80570152
84calcium-mediated signaling using intracellular calcium source (GO:0035584)2.79788489
85mating behavior (GO:0007617)2.79547606
86activation of protein kinase A activity (GO:0034199)2.78419157
87positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.77313423
88dendritic spine organization (GO:0097061)2.77256231
89regulation of neurotransmitter secretion (GO:0046928)2.76395113
90vesicle transport along microtubule (GO:0047496)2.76378444
91regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.74696701
92behavioral fear response (GO:0001662)2.74369153
93behavioral defense response (GO:0002209)2.74369153
94regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.73718760
95desmosome organization (GO:0002934)2.73120729
96fear response (GO:0042596)2.72759912
97maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.72243027
98chemosensory behavior (GO:0007635)2.71705929
99regulation of voltage-gated calcium channel activity (GO:1901385)2.71268077
100response to auditory stimulus (GO:0010996)2.70288746
101potassium ion import (GO:0010107)2.69948166
102positive regulation of synaptic transmission, GABAergic (GO:0032230)2.68902886
103regulation of neurotransmitter levels (GO:0001505)2.68526318
104regulation of beta-amyloid formation (GO:1902003)2.67496443
105potassium ion homeostasis (GO:0055075)2.67183679
106regulation of glutamate secretion (GO:0014048)2.67129313
107membrane depolarization (GO:0051899)2.65084432
108positive regulation of dendritic spine development (GO:0060999)2.64996404
109regulation of dendritic spine development (GO:0060998)2.64906517
110acidic amino acid transport (GO:0015800)2.64521747
111learning (GO:0007612)2.63494041
112neuromuscular process controlling posture (GO:0050884)2.63140288
113regulation of early endosome to late endosome transport (GO:2000641)2.62624241
114protein retention in ER lumen (GO:0006621)2.61840587
115positive regulation of neurotransmitter secretion (GO:0001956)2.61424786
116regulation of synaptic transmission (GO:0050804)2.60690203
117synapse assembly (GO:0007416)2.60084307
118cellular sodium ion homeostasis (GO:0006883)2.60020788
119positive regulation of synapse maturation (GO:0090129)2.57889583
120regulation of neurotransmitter transport (GO:0051588)2.56899090
121membrane depolarization during action potential (GO:0086010)2.56189585
122synapse organization (GO:0050808)2.55318150
123positive regulation of neurotransmitter transport (GO:0051590)2.54637052
124regulation of synapse maturation (GO:0090128)2.50571363
125skin morphogenesis (GO:0043589)2.50408990
126vesicle docking involved in exocytosis (GO:0006904)2.47030587
127myelin maintenance (GO:0043217)2.41954452
128negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.38745209
129positive regulation of vesicle fusion (GO:0031340)2.38257990
130vesicle docking (GO:0048278)2.37544579
131positive regulation of dendritic spine morphogenesis (GO:0061003)2.35116788
132dicarboxylic acid transport (GO:0006835)2.33881891
133positive regulation of fibroblast migration (GO:0010763)2.33863656
134positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.33623612
135regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.31641964
136L-glutamate transport (GO:0015813)2.30422278

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.71484885
2EZH2_22144423_ChIP-Seq_EOC_Human5.21795626
3GBX2_23144817_ChIP-Seq_PC3_Human3.53311629
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.10619932
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.07241042
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.91689812
7THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.67728847
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.66984007
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.63375989
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.63375989
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.60448875
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.60416135
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.59362140
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.51693503
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.47984391
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.45612765
17PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.44533211
18TRIM28_21343339_ChIP-Seq_HEK293_Human2.42962471
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.41352927
20REST_21632747_ChIP-Seq_MESCs_Mouse2.34944414
21RARG_19884340_ChIP-ChIP_MEFs_Mouse2.14351723
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.14129317
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.13074740
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.09799739
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.07180966
26DROSHA_22980978_ChIP-Seq_HELA_Human2.05822084
27RARB_27405468_Chip-Seq_BRAIN_Mouse2.05649889
28IKZF1_21737484_ChIP-ChIP_HCT116_Human1.88957385
29REST_18959480_ChIP-ChIP_MESCs_Mouse1.86133563
30ESR2_21235772_ChIP-Seq_MCF-7_Human1.82227093
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77913013
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.77367807
33TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.72300189
34TAF15_26573619_Chip-Seq_HEK293_Human1.71202239
35AR_21572438_ChIP-Seq_LNCaP_Human1.71138308
36CLOCK_20551151_ChIP-Seq_293T_Human1.70852438
37SMAD4_21799915_ChIP-Seq_A2780_Human1.63030098
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.62962455
39KDM2B_26808549_Chip-Seq_K562_Human1.62177189
40SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.57694612
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.51307710
42GATA2_21666600_ChIP-Seq_HMVEC_Human1.50524848
43P300_19829295_ChIP-Seq_ESCs_Human1.50214905
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49097534
45NR3C1_23031785_ChIP-Seq_PC12_Mouse1.49011076
46ZFP281_18757296_ChIP-ChIP_E14_Mouse1.49010031
47ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.47192386
48TET1_21490601_ChIP-Seq_MESCs_Mouse1.45694908
49PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.44492742
50DNAJC2_21179169_ChIP-ChIP_NT2_Human1.43772270
51CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.43768853
52ZNF274_21170338_ChIP-Seq_K562_Hela1.43661094
53TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43636796
54CDX2_19796622_ChIP-Seq_MESCs_Mouse1.43542818
55NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.42654158
56PIAS1_25552417_ChIP-Seq_VCAP_Human1.40631753
57RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.40061592
58VDR_22108803_ChIP-Seq_LS180_Human1.39940322
59* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39173413
60OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38869704
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37695894
62SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.37194879
63RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.36247275
64ERG_21242973_ChIP-ChIP_JURKAT_Human1.33852804
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32515316
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.32030043
67BMI1_23680149_ChIP-Seq_NPCS_Mouse1.31487371
68CBX2_27304074_Chip-Seq_ESCs_Mouse1.30675883
69KDM2B_26808549_Chip-Seq_SUP-B15_Human1.29970844
70MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.29918934
71TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.29040332
72* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27325684
73AR_25329375_ChIP-Seq_VCAP_Human1.27162089
74POU3F2_20337985_ChIP-ChIP_501MEL_Human1.26718083
75* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.25881019
76* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.25881019
77SOX9_24532713_ChIP-Seq_HFSC_Mouse1.24386522
78EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.23314245
79LXR_22292898_ChIP-Seq_THP-1_Human1.21440408
80SOX2_21211035_ChIP-Seq_LN229_Gbm1.21267090
81RING1B_27294783_Chip-Seq_ESCs_Mouse1.21137002
82CTNNB1_20460455_ChIP-Seq_HCT116_Human1.21033023
83* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.20510056
84TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19787250
85ZFP281_27345836_Chip-Seq_ESCs_Mouse1.18811375
86STAT3_23295773_ChIP-Seq_U87_Human1.18748423
87* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.17000681
88IGF1R_20145208_ChIP-Seq_DFB_Human1.15566006
89CJUN_26792858_Chip-Seq_BT549_Human1.15348661
90ZNF217_24962896_ChIP-Seq_MCF-7_Human1.13143463
91ZNF263_19887448_ChIP-Seq_K562_Human1.11596023
92TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11259275
93UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11205970
94SMAD_19615063_ChIP-ChIP_OVARY_Human1.09694207
95TP53_18474530_ChIP-ChIP_U2OS_Human1.09077898
96FUS_26573619_Chip-Seq_HEK293_Human1.08397645
97ARNT_22903824_ChIP-Seq_MCF-7_Human1.08325391
98EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08129335
99BCAT_22108803_ChIP-Seq_LS180_Human1.07972266
100* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07911700
101EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.07592741
102ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.07544789
103SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.07441732
104TP53_16413492_ChIP-PET_HCT116_Human1.07178915
105NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06030849
106* TP53_23651856_ChIP-Seq_MEFs_Mouse1.05609620
107AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05587212
108AR_19668381_ChIP-Seq_PC3_Human1.05395406
109SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05093723
110CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.04225001
111ESR1_21235772_ChIP-Seq_MCF-7_Human1.03442152
112RUNX2_22187159_ChIP-Seq_PCA_Human1.02809474
113SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.02291268
114TCF4_23295773_ChIP-Seq_U87_Human1.02244540
115* PRDM14_20953172_ChIP-Seq_ESCs_Human1.02138706
116JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01380239
117AHR_22903824_ChIP-Seq_MCF-7_Human1.01005343
118ELK3_25401928_ChIP-Seq_HUVEC_Human0.99965500
119MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99406659
120SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.98995116
121TBX20_22328084_ChIP-Seq_HEART_Mouse0.98805599
122TBX20_22080862_ChIP-Seq_HEART_Mouse0.98805599
123P63_26484246_Chip-Seq_KERATINOCYTES_Human0.97525425
124RING1B_27294783_Chip-Seq_NPCs_Mouse0.96668856
125ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.94423314
126TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94386419
127YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93646119
128RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.93637412
129TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.93442080
130DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.93315610
131WT1_19549856_ChIP-ChIP_CCG9911_Human0.93187748
132NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.92861283
133NRF2_20460467_ChIP-Seq_MEFs_Mouse0.92861283
134JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92697945
135ER_23166858_ChIP-Seq_MCF-7_Human0.92645711
136CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.92591564
137UBF1/2_26484160_Chip-Seq_HMECs_Human0.92369211
138NANOG_18555785_Chip-Seq_ESCs_Mouse0.90992370
139NFIB_24661679_ChIP-Seq_LUNG_Mouse0.90947057
140RNF2_27304074_Chip-Seq_NSC_Mouse0.90923653
141WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.90461864
142EP300_21415370_ChIP-Seq_HL-1_Mouse0.90336989
143P53_22127205_ChIP-Seq_FIBROBLAST_Human0.89985959
144SMAD4_21741376_ChIP-Seq_HESCs_Human0.89909844
145ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.89681984
146TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.89254256
147RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.88879511
148ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88497892
149SMAD3_21741376_ChIP-Seq_HESCs_Human0.88095609
150JUN_21703547_ChIP-Seq_K562_Human0.87968014
151SOX2_20726797_ChIP-Seq_SW620_Human0.87242207
152SMAD3_21741376_ChIP-Seq_ESCs_Human0.86977955
153RXR_22108803_ChIP-Seq_LS180_Human0.86580019
154GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.86035937
155OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.84719723
156SRY_22984422_ChIP-ChIP_TESTIS_Rat0.84197200

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.34910878
2MP0003880_abnormal_central_pattern5.17274129
3* MP0003635_abnormal_synaptic_transmissio3.68234488
4MP0004270_analgesia3.58009625
5MP0009745_abnormal_behavioral_response3.08570326
6MP0000579_abnormal_nail_morphology3.04646920
7* MP0002063_abnormal_learning/memory/cond2.95164059
8MP0002064_seizures2.90930130
9MP0008438_abnormal_cutaneous_collagen2.83271701
10MP0001968_abnormal_touch/_nociception2.66112462
11MP0009780_abnormal_chondrocyte_physiolo2.55716373
12* MP0002572_abnormal_emotion/affect_behav2.54647779
13MP0009046_muscle_twitch2.52884371
14* MP0002272_abnormal_nervous_system2.48009712
15MP0001486_abnormal_startle_reflex2.38366633
16MP0002734_abnormal_mechanical_nocicepti2.35379771
17MP0002736_abnormal_nociception_after2.29310503
18MP0005423_abnormal_somatic_nervous2.23566068
19MP0003705_abnormal_hypodermis_morpholog2.22171046
20MP0002909_abnormal_adrenal_gland2.09236727
21MP0003566_abnormal_cell_adhesion2.08845321
22MP0002837_dystrophic_cardiac_calcinosis2.05443174
23MP0002735_abnormal_chemical_nociception1.99900513
24* MP0001501_abnormal_sleep_pattern1.97956787
25MP0005275_abnormal_skin_tensile1.96064718
26* MP0001440_abnormal_grooming_behavior1.95701575
27MP0002733_abnormal_thermal_nociception1.94343183
28* MP0003329_amyloid_beta_deposits1.90837999
29MP0004272_abnormal_basement_membrane1.88964384
30MP0001970_abnormal_pain_threshold1.85409905
31MP0004858_abnormal_nervous_system1.82958773
32MP0005646_abnormal_pituitary_gland1.80455136
33MP0006276_abnormal_autonomic_nervous1.76018752
34* MP0002067_abnormal_sensory_capabilities1.75925593
35MP0000013_abnormal_adipose_tissue1.74178645
36MP0001958_emphysema1.68573161
37MP0000778_abnormal_nervous_system1.67815383
38MP0005645_abnormal_hypothalamus_physiol1.65839736
39MP0008569_lethality_at_weaning1.63350104
40MP0002822_catalepsy1.62690652
41MP0004885_abnormal_endolymph1.60716032
42MP0001529_abnormal_vocalization1.60231610
43MP0001984_abnormal_olfaction1.60228008
44MP0002184_abnormal_innervation1.59824757
45MP0002557_abnormal_social/conspecific_i1.52978260
46MP0004510_myositis1.49676229
47MP0010234_abnormal_vibrissa_follicle1.47808004
48MP0002877_abnormal_melanocyte_morpholog1.45498222
49MP0001905_abnormal_dopamine_level1.45429174
50MP0003191_abnormal_cellular_cholesterol1.43780568
51MP0001502_abnormal_circadian_rhythm1.42351795
52MP0002060_abnormal_skin_morphology1.41989505
53MP0000955_abnormal_spinal_cord1.41720954
54MP0003633_abnormal_nervous_system1.38096297
55MP0003172_abnormal_lysosome_physiology1.37902205
56MP0003091_abnormal_cell_migration1.37601436
57MP0010386_abnormal_urinary_bladder1.33586219
58* MP0004924_abnormal_behavior1.32867861
59* MP0005386_behavior/neurological_phenoty1.32867861
60MP0005058_abnormal_lysosome_morphology1.32826823
61MP0005257_abnormal_intraocular_pressure1.31969243
62* MP0002882_abnormal_neuron_morphology1.31108200
63* MP0002066_abnormal_motor_capabilities/c1.30471380
64MP0000762_abnormal_tongue_morphology1.29539616
65MP0001348_abnormal_lacrimal_gland1.28385913
66MP0003690_abnormal_glial_cell1.27774138
67MP0004811_abnormal_neuron_physiology1.27516830
68MP0000920_abnormal_myelination1.24850169
69MP0003283_abnormal_digestive_organ1.24742321
70MP0004043_abnormal_pH_regulation1.24353228
71MP0005551_abnormal_eye_electrophysiolog1.23210856
72MP0005023_abnormal_wound_healing1.21571086
73MP0004145_abnormal_muscle_electrophysio1.18753807
74MP0003453_abnormal_keratinocyte_physiol1.18651011
75MP0003879_abnormal_hair_cell1.17345683
76MP0001849_ear_inflammation1.15427260
77* MP0003634_abnormal_glial_cell1.14422871
78MP0004142_abnormal_muscle_tone1.14013934
79MP0003045_fibrosis1.12739112
80MP0005165_increased_susceptibility_to1.10600113
81MP0000751_myopathy1.09607932
82* MP0003631_nervous_system_phenotype1.08954440
83MP0005379_endocrine/exocrine_gland_phen1.08932289
84MP0008260_abnormal_autophagy1.08506367
85MP0003279_aneurysm1.06831358
86* MP0002229_neurodegeneration1.04475522
87MP0002295_abnormal_pulmonary_circulatio1.03925298
88MP0002876_abnormal_thyroid_physiology1.01728155
89MP0002896_abnormal_bone_mineralization1.01383355
90MP0003122_maternal_imprinting0.98771424
91MP0006072_abnormal_retinal_apoptosis0.94277072
92MP0009840_abnormal_foam_cell0.93966003
93MP0001188_hyperpigmentation0.93312604
94* MP0002152_abnormal_brain_morphology0.92789340
95MP0004742_abnormal_vestibular_system0.92199040
96MP0003950_abnormal_plasma_membrane0.89368814
97MP0005166_decreased_susceptibility_to0.88770507
98MP0002069_abnormal_eating/drinking_beha0.88627734
99MP0004215_abnormal_myocardial_fiber0.87699672
100MP0000467_abnormal_esophagus_morphology0.86942484
101MP0001485_abnormal_pinna_reflex0.86713351
102MP0001963_abnormal_hearing_physiology0.85862514
103* MP0005535_abnormal_body_temperature0.85414733
104MP0005623_abnormal_meninges_morphology0.84937820
105MP0004085_abnormal_heartbeat0.84807519
106MP0002638_abnormal_pupillary_reflex0.84690973
107MP0010771_integument_phenotype0.83991006
108MP0001664_abnormal_digestion0.82848285
109MP0003075_altered_response_to0.82802453
110MP0002090_abnormal_vision0.82074425
111MP0004484_altered_response_of0.81745115
112MP0000631_abnormal_neuroendocrine_gland0.79593947
113MP0005388_respiratory_system_phenotype0.79458751
114MP0002133_abnormal_respiratory_system0.79458751
115MP0002089_abnormal_postnatal_growth/wei0.78488500
116MP0001299_abnormal_eye_distance/0.77450740
117MP0002752_abnormal_somatic_nervous0.76500940
118MP0001177_atelectasis0.76344928
119* MP0000604_amyloidosis0.76227076
120MP0003123_paternal_imprinting0.74406418
121MP0003787_abnormal_imprinting0.73934795
122MP0002796_impaired_skin_barrier0.73418031
123MP0003300_gastrointestinal_ulcer0.71706074
124* MP0003632_abnormal_nervous_system0.71206999
125MP0008874_decreased_physiological_sensi0.71137378
126MP0002234_abnormal_pharynx_morphology0.70941855
127MP0001542_abnormal_bone_strength0.70910741
128MP0005171_absent_coat_pigmentation0.70007675
129MP0005409_darkened_coat_color0.68330558
130MP0003183_abnormal_peptide_metabolism0.67746318
131MP0001851_eye_inflammation0.66594856
132MP0004036_abnormal_muscle_relaxation0.65817210
133MP0003137_abnormal_impulse_conducting0.65782485
134MP0010368_abnormal_lymphatic_system0.65311907
135MP0000003_abnormal_adipose_tissue0.65303269
136MP0005253_abnormal_eye_physiology0.64584623
137MP0005595_abnormal_vascular_smooth0.63942483
138MP0005164_abnormal_response_to0.62841856
139MP0004947_skin_inflammation0.62840616
140MP0001216_abnormal_epidermal_layer0.62774420
141MP0000026_abnormal_inner_ear0.60658870
142MP0005620_abnormal_muscle_contractility0.59021907
143* MP0001765_abnormal_ion_homeostasis0.58972941
144MP0000747_muscle_weakness0.58913378

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.85223808
2Focal seizures (HP:0007359)4.98077660
3Visual hallucinations (HP:0002367)4.96229541
4Myokymia (HP:0002411)4.92142522
5Atonic seizures (HP:0010819)4.50536104
6Epileptic encephalopathy (HP:0200134)4.45426174
7Atrophic scars (HP:0001075)4.24939600
8Absence seizures (HP:0002121)4.00909001
9Dialeptic seizures (HP:0011146)3.76223662
10Generalized tonic-clonic seizures (HP:0002069)3.63363213
11Milia (HP:0001056)3.50898006
12Onycholysis (HP:0001806)3.48010184
13Hyperventilation (HP:0002883)3.47263735
14Febrile seizures (HP:0002373)3.47257903
15* Cerebral inclusion bodies (HP:0100314)3.40754866
16Action tremor (HP:0002345)3.29848998
17Progressive cerebellar ataxia (HP:0002073)3.29227583
18Megalencephaly (HP:0001355)3.19611248
19Premature rupture of membranes (HP:0001788)3.16255484
20* Neurofibrillary tangles (HP:0002185)3.14507572
21Protrusio acetabuli (HP:0003179)2.91498071
22Fragile nails (HP:0001808)2.90387879
23Aplasia involving bones of the extremities (HP:0009825)2.85071657
24Aplasia involving bones of the upper limbs (HP:0009823)2.85071657
25Aplasia of the phalanges of the hand (HP:0009802)2.85071657
26Dysdiadochokinesis (HP:0002075)2.84039644
27Amblyopia (HP:0000646)2.83407321
28Broad-based gait (HP:0002136)2.79489705
29* Supranuclear gaze palsy (HP:0000605)2.79106292
30Arterial tortuosity (HP:0005116)2.76256439
31Vascular tortuosity (HP:0004948)2.74306609
32Pheochromocytoma (HP:0002666)2.74194680
33Plantar hyperkeratosis (HP:0007556)2.74087296
34Distal upper limb amyotrophy (HP:0007149)2.73080829
35Upper limb amyotrophy (HP:0009129)2.73080829
36Abnormality of nail color (HP:0100643)2.72488422
37Obstructive sleep apnea (HP:0002870)2.71624874
38Epileptiform EEG discharges (HP:0011182)2.71469465
39* Dysmetria (HP:0001310)2.70546287
40* Anxiety (HP:0000739)2.68010863
41Termporal pattern (HP:0011008)2.66738273
42Insidious onset (HP:0003587)2.66738273
43Retinal dysplasia (HP:0007973)2.65380856
44Thick nail (HP:0001805)2.61192356
45Hand muscle atrophy (HP:0009130)2.61072147
46Ankle clonus (HP:0011448)2.60802793
47* Abnormality of binocular vision (HP:0011514)2.59891885
48* Diplopia (HP:0000651)2.59891885
49EEG with generalized epileptiform discharges (HP:0011198)2.57677750
50Drooling (HP:0002307)2.57553901
51Excessive salivation (HP:0003781)2.57553901
52Degeneration of the lateral corticospinal tracts (HP:0002314)2.55915431
53Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.55915431
54Abnormal eating behavior (HP:0100738)2.51116483
55Abnormality of the corticospinal tract (HP:0002492)2.50302036
56Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.48155762
57Fragile skin (HP:0001030)2.47657244
58Poor eye contact (HP:0000817)2.46890628
59Vertebral compression fractures (HP:0002953)2.42710642
60Neuroendocrine neoplasm (HP:0100634)2.41702242
61Intention tremor (HP:0002080)2.41550875
62Scanning speech (HP:0002168)2.41107851
63Hypsarrhythmia (HP:0002521)2.38308523
64Impaired vibration sensation in the lower limbs (HP:0002166)2.37660630
65* Depression (HP:0000716)2.37167454
66Tetraplegia (HP:0002445)2.34090925
67Alopecia of scalp (HP:0002293)2.33911699
68* Truncal ataxia (HP:0002078)2.33511398
69Lower limb amyotrophy (HP:0007210)2.32979602
70Nail dystrophy (HP:0008404)2.31367340
71Axonal loss (HP:0003447)2.29026419
72Spastic gait (HP:0002064)2.28721759
73Gaze-evoked nystagmus (HP:0000640)2.28400853
74Increased circulating renin level (HP:0000848)2.27820058
75Postural instability (HP:0002172)2.25465301
76* Neuronal loss in central nervous system (HP:0002529)2.23779372
77Impaired social interactions (HP:0000735)2.23318442
78Abnormal social behavior (HP:0012433)2.23318442
79Cerebral aneurysm (HP:0004944)2.22994846
80Shallow orbits (HP:0000586)2.18606595
81Type II lissencephaly (HP:0007260)2.17887997
82Thickened helices (HP:0000391)2.15669818
83Follicular hyperkeratosis (HP:0007502)2.15073505
84Progressive inability to walk (HP:0002505)2.11008634
85Urinary bladder sphincter dysfunction (HP:0002839)2.10853487
86Annular pancreas (HP:0001734)2.10787583
87Clumsiness (HP:0002312)2.10555396
88Hemiplegia (HP:0002301)2.09147066
89Generalized myoclonic seizures (HP:0002123)2.07665459
90Absent speech (HP:0001344)2.07343947
91Agitation (HP:0000713)2.06294482
92Ankyloglossia (HP:0010296)2.06194086
93* Hemiparesis (HP:0001269)2.05275817
94Craniofacial dystonia (HP:0012179)2.04856038
95Abnormality of glycolipid metabolism (HP:0010969)2.01660595
96Abnormality of liposaccharide metabolism (HP:0010968)2.01660595
97Abnormality of glycosphingolipid metabolism (HP:0004343)2.01660595
98Urinary urgency (HP:0000012)1.99875307
99Wormian bones (HP:0002645)1.98019088
100Akinesia (HP:0002304)1.97264561
101Papilledema (HP:0001085)1.97172851
102Peripheral hypomyelination (HP:0007182)1.96108072
103Abnormal blistering of the skin (HP:0008066)1.93806602
104Osteolytic defects of the phalanges of the hand (HP:0009771)1.93224243
105Osteolytic defects of the hand bones (HP:0009699)1.93224243
106Cervical subluxation (HP:0003308)1.92990933
107Nuclear cataract (HP:0100018)1.92712639
108Gait imbalance (HP:0002141)1.91645660
109Abnormality of calcium-phosphate metabolism (HP:0100530)1.91478274
110Short nail (HP:0001799)1.91018536
111Distal sensory impairment (HP:0002936)1.90558003
112* Rigidity (HP:0002063)1.90454493
113Hammertoe (HP:0001765)1.90337537
114Palmoplantar hyperkeratosis (HP:0000972)1.90184604
115Abnormality of salivation (HP:0100755)1.88858003
116Mutism (HP:0002300)1.88335931
117Dysostosis multiplex (HP:0000943)1.87758822
118Status epilepticus (HP:0002133)1.87572544
119Abnormality of the lower motor neuron (HP:0002366)1.86161991
120Distal lower limb amyotrophy (HP:0008944)1.85187008
121Decreased circulating renin level (HP:0003351)1.84334489
122Polyphagia (HP:0002591)1.83112549
123* Rapidly progressive (HP:0003678)1.82230168
124Palmar hyperkeratosis (HP:0010765)1.80100189
125Bladder diverticulum (HP:0000015)1.79696939
126Split foot (HP:0001839)1.79661108
127Cerebral hypomyelination (HP:0006808)1.79459038
128Spinal rigidity (HP:0003306)1.79090881
129* Psychosis (HP:0000709)1.78948999
130Abnormality of oral frenula (HP:0000190)1.78508529
131Stereotypic behavior (HP:0000733)1.78257680
132Hyperparathyroidism (HP:0000843)1.78021113
133Clonus (HP:0002169)1.77003348
134Limb dystonia (HP:0002451)1.76325732
135Aortic dissection (HP:0002647)1.75763606
136Blue irides (HP:0000635)1.75515794
137* Apathy (HP:0000741)1.75375587
138Difficulty climbing stairs (HP:0003551)1.73760424
139Humeroradial synostosis (HP:0003041)1.73432074
140Synostosis involving the elbow (HP:0003938)1.73432074
141Upper limb muscle weakness (HP:0003484)1.73073049
142Hypoplasia of dental enamel (HP:0006297)1.73037349
143Torticollis (HP:0000473)1.72988887
144Postural tremor (HP:0002174)1.70456067
145Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.70260635
146Hydroureter (HP:0000072)1.69537355
147Syncope (HP:0001279)1.67782525
148Buphthalmos (HP:0000557)1.67251349
149Inability to walk (HP:0002540)1.67042969
150Congenital primary aphakia (HP:0007707)1.66610962
151Focal dystonia (HP:0004373)1.65386402
152* Bradykinesia (HP:0002067)1.64422149
153Bronchomalacia (HP:0002780)1.63891029
154Medial flaring of the eyebrow (HP:0010747)1.63871249
155Vaginal atresia (HP:0000148)1.62904858
156* Gait ataxia (HP:0002066)1.62048700
157Genital tract atresia (HP:0001827)1.61619581
158Mixed hearing impairment (HP:0000410)1.61336533
159* Lower limb muscle weakness (HP:0007340)1.61217430
160Athetosis (HP:0002305)1.60667925
161Widely spaced teeth (HP:0000687)1.60060907
162Acute necrotizing encephalopathy (HP:0006965)1.57506064
163Progressive macrocephaly (HP:0004481)1.57077251

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.01213008
2NTRK34.25777136
3MAP3K92.90402776
4RIPK42.88686309
5RIPK12.72880637
6MAP3K42.59565863
7NTRK12.24228145
8MINK12.21857431
9PNCK2.16656672
10MAP2K72.15732984
11TESK12.04114284
12KSR21.97618337
13PRKD31.96231255
14MARK11.93378299
15CASK1.90649413
16LIMK11.88167249
17NTRK21.79903239
18PDGFRA1.79099625
19PAK61.77647275
20PLK21.72842164
21GRK51.70108716
22ARAF1.68576854
23DAPK21.67579246
24MAP3K121.65845739
25MAP2K41.61042226
26PTK21.47812304
27BMPR21.46590380
28MAP3K21.44983542
29TNIK1.43626045
30MST1R1.42818956
31PTK2B1.40772902
32* CDK51.36848286
33MAP3K131.34907967
34EPHA21.31072743
35CAMK2A1.28083343
36CAMK2B1.25200017
37OXSR11.25037462
38PHKG11.23780447
39PHKG21.23780447
40KSR11.23533347
41FGR1.21094613
42MET1.18530160
43PRKCG1.16578202
44PAK31.15264143
45STK391.12866716
46UHMK11.11686604
47INSRR1.11073369
48NME11.05870733
49PIM21.04948755
50IRAK31.03011500
51CAMKK11.02715806
52LMTK21.00964906
53FER0.99199140
54CAMK2D0.99065862
55DAPK10.98517135
56CAMKK20.98378067
57SIK20.98304600
58FES0.97643171
59MAPK130.92564311
60CDK190.92427297
61PRKCE0.90534416
62SGK2230.87963881
63SGK4940.87963881
64WNK40.87949906
65TTN0.84407191
66DYRK1A0.82782098
67MAPKAPK50.81884846
68TYRO30.81583632
69EPHB10.77779312
70CDK140.77773079
71SCYL20.77689230
72STK380.77196134
73MUSK0.77092894
74PRPF4B0.77051939
75ERN10.76249684
76ROCK20.74756263
77MAP3K10.73853797
78TAOK20.73256250
79RET0.73159033
80PRKCH0.72396355
81ERBB40.72295470
82ICK0.72036235
83TGFBR20.71110865
84FGFR20.71050903
85BRAF0.70716409
86CDK180.70595904
87CAMK2G0.70532263
88MYLK0.70529125
89CDK150.70423368
90BCR0.69409011
91PAK40.69275949
92RAF10.69067477
93PINK10.67884051
94PAK20.65643958
95SIK10.65617664
96MAP3K30.65217576
97SGK10.65012711
98CAMK1G0.64746771
99EPHB20.64726633
100SGK30.64488964
101WNK10.64346995
102CAMK10.63094230
103JAK10.62949136
104ABL20.61867599
105CDK11A0.58930718
106MAPK150.58023652
107DAPK30.57430350
108STK110.57037649
109PDPK10.56465382
110MAP2K10.56076778
111MARK20.55924582
112CSNK1G20.54719553
113SIK30.54501286
114WNK30.54120367
115PDGFRB0.53176313
116LATS20.51502730
117GRK70.51282699
118ROCK10.50620625
119CDC42BPA0.50269726
120TNK20.49796260
121PRKD20.49081296
122PKN10.48970712
123LATS10.48796605
124DDR20.48165718
125NEK60.46721446
126MOS0.46131331
127ADRBK10.45396427
128MAPK120.45275253
129FYN0.44610561
130MAP3K60.44364388
131PRKACA0.44328557
132PDK10.44184885
133MAP3K110.44047058
134MAPK100.41399830
135RPS6KA30.38914877
136GRK60.38350175

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.57258789
2Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.61425659
3Synaptic vesicle cycle_Homo sapiens_hsa047212.59527222
4GABAergic synapse_Homo sapiens_hsa047272.57498068
5Long-term potentiation_Homo sapiens_hsa047202.57313906
6Circadian entrainment_Homo sapiens_hsa047132.46693936
7Glutamatergic synapse_Homo sapiens_hsa047242.43678728
8Amphetamine addiction_Homo sapiens_hsa050312.38220311
9Morphine addiction_Homo sapiens_hsa050322.28799950
10Olfactory transduction_Homo sapiens_hsa047402.21573741
11Salivary secretion_Homo sapiens_hsa049702.16873909
12Insulin secretion_Homo sapiens_hsa049112.14926386
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.10209832
14Taste transduction_Homo sapiens_hsa047422.02236716
15Dopaminergic synapse_Homo sapiens_hsa047281.97525186
16Gastric acid secretion_Homo sapiens_hsa049711.86809911
17Renin secretion_Homo sapiens_hsa049241.83507540
18Collecting duct acid secretion_Homo sapiens_hsa049661.81948051
19Serotonergic synapse_Homo sapiens_hsa047261.81385422
20Long-term depression_Homo sapiens_hsa047301.64512697
21Cocaine addiction_Homo sapiens_hsa050301.62938833
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.57587313
23Cholinergic synapse_Homo sapiens_hsa047251.57459746
24Calcium signaling pathway_Homo sapiens_hsa040201.55461516
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.51763899
26ECM-receptor interaction_Homo sapiens_hsa045121.46607872
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.45461295
28Oxytocin signaling pathway_Homo sapiens_hsa049211.42254705
29Vibrio cholerae infection_Homo sapiens_hsa051101.37313639
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.29627817
31GnRH signaling pathway_Homo sapiens_hsa049121.28878643
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.27412059
33Vitamin B6 metabolism_Homo sapiens_hsa007501.26786883
34Cardiac muscle contraction_Homo sapiens_hsa042601.23611868
35cAMP signaling pathway_Homo sapiens_hsa040241.19132606
36Gap junction_Homo sapiens_hsa045401.18405829
37* Prion diseases_Homo sapiens_hsa050201.17721869
38Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.17195014
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.16586666
40Focal adhesion_Homo sapiens_hsa045101.14836069
41Oxidative phosphorylation_Homo sapiens_hsa001901.14682353
42Alzheimers disease_Homo sapiens_hsa050101.13917141
43Pancreatic secretion_Homo sapiens_hsa049721.10219919
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.10004680
45Phototransduction_Homo sapiens_hsa047441.09460863
46Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.08069455
47Glycosaminoglycan degradation_Homo sapiens_hsa005311.05310641
48cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03507233
49Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03280624
50Melanogenesis_Homo sapiens_hsa049161.03201474
51Estrogen signaling pathway_Homo sapiens_hsa049151.02987668
52Vascular smooth muscle contraction_Homo sapiens_hsa042701.02883478
53Axon guidance_Homo sapiens_hsa043600.99629693
54Type II diabetes mellitus_Homo sapiens_hsa049300.98831304
55Amoebiasis_Homo sapiens_hsa051460.98591516
56Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.97559271
57Proteoglycans in cancer_Homo sapiens_hsa052050.91314000
58Neurotrophin signaling pathway_Homo sapiens_hsa047220.90993116
59Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.88990102
60Thyroid hormone synthesis_Homo sapiens_hsa049180.88503793
61Nitrogen metabolism_Homo sapiens_hsa009100.88279974
62Lysosome_Homo sapiens_hsa041420.83352665
63Glioma_Homo sapiens_hsa052140.82616385
64Dorso-ventral axis formation_Homo sapiens_hsa043200.79860881
65Thyroid hormone signaling pathway_Homo sapiens_hsa049190.79631707
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77065944
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76499904
68Other glycan degradation_Homo sapiens_hsa005110.75495264
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.73079433
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72970444
71Parkinsons disease_Homo sapiens_hsa050120.72885977
72Dilated cardiomyopathy_Homo sapiens_hsa054140.72418115
73Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.70498913
74Salmonella infection_Homo sapiens_hsa051320.70025614
75Regulation of actin cytoskeleton_Homo sapiens_hsa048100.69580685
76ErbB signaling pathway_Homo sapiens_hsa040120.68597995
77AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68298054
78Glucagon signaling pathway_Homo sapiens_hsa049220.66559359
79Choline metabolism in cancer_Homo sapiens_hsa052310.64459791
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62647383
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.61136518
82Central carbon metabolism in cancer_Homo sapiens_hsa052300.59078914
83Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.58425933
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58114286
85Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57303193
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.55841849
87Adherens junction_Homo sapiens_hsa045200.55337081
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.54826193
89Ras signaling pathway_Homo sapiens_hsa040140.54535140
90Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53260311
91Mineral absorption_Homo sapiens_hsa049780.53105671
92Fatty acid biosynthesis_Homo sapiens_hsa000610.52960552
93mTOR signaling pathway_Homo sapiens_hsa041500.52728527
94Type I diabetes mellitus_Homo sapiens_hsa049400.52135512
95VEGF signaling pathway_Homo sapiens_hsa043700.51583564
96Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.51425736
97Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.50587000
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50352061
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49718630
100MAPK signaling pathway_Homo sapiens_hsa040100.49381569
101Protein digestion and absorption_Homo sapiens_hsa049740.49162411
102Shigellosis_Homo sapiens_hsa051310.48595040
103Sulfur metabolism_Homo sapiens_hsa009200.48153259
104Bile secretion_Homo sapiens_hsa049760.47879114
105Insulin signaling pathway_Homo sapiens_hsa049100.47840107
106Circadian rhythm_Homo sapiens_hsa047100.45676648
107Phagosome_Homo sapiens_hsa041450.45672955
108Oocyte meiosis_Homo sapiens_hsa041140.45652148
109African trypanosomiasis_Homo sapiens_hsa051430.45435677
110Inositol phosphate metabolism_Homo sapiens_hsa005620.45421770
111Hippo signaling pathway_Homo sapiens_hsa043900.45060173
112Rap1 signaling pathway_Homo sapiens_hsa040150.43467625
113Huntingtons disease_Homo sapiens_hsa050160.41854261
114Ether lipid metabolism_Homo sapiens_hsa005650.40773380
115Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.40243097
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.39811066
117Rheumatoid arthritis_Homo sapiens_hsa053230.39211597
118SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37509128
119Ovarian steroidogenesis_Homo sapiens_hsa049130.36532414
120Wnt signaling pathway_Homo sapiens_hsa043100.35781105
121Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.35613598
122Renal cell carcinoma_Homo sapiens_hsa052110.34908049
123Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34419998
124Alcoholism_Homo sapiens_hsa050340.33866120
125Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.33334559
126Sphingolipid metabolism_Homo sapiens_hsa006000.31287418
127Endocytosis_Homo sapiens_hsa041440.29910987
128Butanoate metabolism_Homo sapiens_hsa006500.29571373
129Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.28498658

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