PRNT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromosome condensation (GO:0030261)9.78820765
2DNA packaging (GO:0006323)9.50577156
3sperm capacitation (GO:0048240)9.23577766
4response to pheromone (GO:0019236)8.76053551
5single strand break repair (GO:0000012)8.64022463
6spermatid nucleus differentiation (GO:0007289)8.62149973
7spermatid development (GO:0007286)8.05299644
8microtubule depolymerization (GO:0007019)7.83982461
9plasma membrane fusion (GO:0045026)7.72585726
10rRNA methylation (GO:0031167)7.38868160
11sexual reproduction (GO:0019953)7.26188134
12protein polyglutamylation (GO:0018095)7.21212829
13protein targeting to Golgi (GO:0000042)7.19901140
14sperm-egg recognition (GO:0035036)7.18045147
15establishment of protein localization to Golgi (GO:0072600)6.93791029
16retrograde transport, vesicle recycling within Golgi (GO:0000301)6.73376859
17microtubule polymerization or depolymerization (GO:0031109)6.73049871
18multicellular organism reproduction (GO:0032504)6.69382111
19reproduction (GO:0000003)6.61227523
20binding of sperm to zona pellucida (GO:0007339)6.56853650
21calcium ion-dependent exocytosis (GO:0017156)6.52928870
22phosphatidylethanolamine biosynthetic process (GO:0006646)6.50696034
23negative regulation of inclusion body assembly (GO:0090084)6.43012425
24axonemal dynein complex assembly (GO:0070286)6.38502866
25rRNA modification (GO:0000154)6.18810876
26spermatogenesis (GO:0007283)6.18434714
27male gamete generation (GO:0048232)6.16366216
28phosphatidylethanolamine metabolic process (GO:0046337)5.99779372
29cell-cell recognition (GO:0009988)5.87155188
30centriole replication (GO:0007099)5.85025720
31microtubule severing (GO:0051013)5.83543295
32gamete generation (GO:0007276)5.64908849
33regulation of cilium movement (GO:0003352)5.27436318
34cellular ketone body metabolic process (GO:0046950)5.18241849
35protein localization to Golgi apparatus (GO:0034067)5.13218904
36centriole assembly (GO:0098534)5.11613074
37motile cilium assembly (GO:0044458)5.09472479
38RNA destabilization (GO:0050779)5.06037459
39cilium or flagellum-dependent cell motility (GO:0001539)4.87573702
40positive regulation of Rab GTPase activity (GO:0032851)4.86898447
41regulation of Rab GTPase activity (GO:0032313)4.86898447
42single fertilization (GO:0007338)4.82904703
43cell wall macromolecule catabolic process (GO:0016998)4.81181508
44chromatin silencing (GO:0006342)4.76733566
45antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.72202313
46regulation of centriole replication (GO:0046599)4.64508504
47germ cell development (GO:0007281)4.64367208
48cell wall macromolecule metabolic process (GO:0044036)4.59202014
49ketone body metabolic process (GO:1902224)4.56907597
50regulation of inclusion body assembly (GO:0090083)4.55769139
51multicellular organismal reproductive process (GO:0048609)4.53537373
52cellular process involved in reproduction in multicellular organism (GO:0022412)4.39178769
53nucleus organization (GO:0006997)4.33231277
54seminiferous tubule development (GO:0072520)4.28302167
55epithelial cilium movement (GO:0003351)4.20156157
56regulation of transcription involved in cell fate commitment (GO:0060850)4.11755384
57fertilization (GO:0009566)4.10859125
58musculoskeletal movement (GO:0050881)4.00661943
59multicellular organismal movement (GO:0050879)4.00661943
60regulation of microtubule-based movement (GO:0060632)3.86260792
61polyamine biosynthetic process (GO:0006596)3.82449319
62glycerol ether metabolic process (GO:0006662)3.76590256
63negative regulation of Rho protein signal transduction (GO:0035024)3.68754797
64regulation of somitogenesis (GO:0014807)3.67012562
65cilium movement (GO:0003341)3.65356777
66glomerular visceral epithelial cell development (GO:0072015)3.65217459
67response to acidic pH (GO:0010447)3.64859458
68organic cation transport (GO:0015695)3.58439155
69protein-DNA complex disassembly (GO:0032986)3.57697018
70nucleosome disassembly (GO:0006337)3.57697018
71regulation of interleukin-13 production (GO:0032656)3.55068005
72microtubule nucleation (GO:0007020)3.52329679
73glomerular epithelial cell development (GO:0072310)3.50345986
74coenzyme catabolic process (GO:0009109)3.47911387
75ether metabolic process (GO:0018904)3.47336714
76regulation of T-helper 2 cell differentiation (GO:0045628)3.41949137
77homeostasis of number of cells within a tissue (GO:0048873)3.25978831
78cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.21207334
79negative regulation of gene expression, epigenetic (GO:0045814)3.19579139
80multicellular organismal development (GO:0007275)3.07732069
81regulation of phosphoprotein phosphatase activity (GO:0043666)3.06813914
82cellular response to pH (GO:0071467)3.04413181
83histone H3-K9 demethylation (GO:0033169)3.00817707
84DNA conformation change (GO:0071103)2.98816260
85cranial nerve morphogenesis (GO:0021602)2.97365544
86cerebral cortex neuron differentiation (GO:0021895)2.94990540
87protein depolymerization (GO:0051261)2.91727330
88cell recognition (GO:0008037)2.88310557
89membrane protein intracellular domain proteolysis (GO:0031293)2.88145616
90peptidyl-threonine dephosphorylation (GO:0035970)2.81381619
91negative regulation of histone methylation (GO:0031061)2.78069135
92RNA localization (GO:0006403)2.77752302
93intra-Golgi vesicle-mediated transport (GO:0006891)2.74643161
94epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.72607038
95mitochondrial fission (GO:0000266)2.71621716
96mesenchymal cell differentiation involved in kidney development (GO:0072161)2.71223748
97mesenchymal cell differentiation involved in renal system development (GO:2001012)2.71223748
98sperm motility (GO:0030317)12.0302593
99acrosome reaction (GO:0007340)11.8916963
100fusion of sperm to egg plasma membrane (GO:0007342)10.2020847

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.36572541
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.33554986
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.28797403
4POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.41850260
5TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.41850260
6EZH2_22144423_ChIP-Seq_EOC_Human2.26900232
7CBP_20019798_ChIP-Seq_JUKART_Human2.21284734
8IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.21284734
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.16076428
10VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.14988001
11CTBP1_25329375_ChIP-Seq_LNCAP_Human2.12253339
12ELF1_20517297_ChIP-Seq_JURKAT_Human1.99212733
13FUS_26573619_Chip-Seq_HEK293_Human1.95018966
14DROSHA_22980978_ChIP-Seq_HELA_Human1.93888719
15ERA_21632823_ChIP-Seq_H3396_Human1.91507853
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.84540848
17EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.82286313
18RAC3_21632823_ChIP-Seq_H3396_Human1.78729883
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.78618254
20NANOG_20526341_ChIP-Seq_ESCs_Human1.77395900
21EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.75193814
22UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.73270800
23WDR5_24793694_ChIP-Seq_LNCAP_Human1.73205110
24RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.73058998
25EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.65513989
26CTCF_27219007_Chip-Seq_Bcells_Human1.65439973
27ER_23166858_ChIP-Seq_MCF-7_Human1.61797178
28TAF2_19829295_ChIP-Seq_ESCs_Human1.60998519
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.59432869
30BCL6_27268052_Chip-Seq_Bcells_Human1.56698574
31YY1_22570637_ChIP-Seq_MALME-3M_Human1.54103367
32TDRD3_21172665_ChIP-Seq_MCF-7_Human1.52844325
33ARNT_22903824_ChIP-Seq_MCF-7_Human1.52174660
34STAT6_21828071_ChIP-Seq_BEAS2B_Human1.51471658
35CTCF_20526341_ChIP-Seq_ESCs_Human1.49538484
36MYC_19829295_ChIP-Seq_ESCs_Human1.48705266
37BCOR_27268052_Chip-Seq_Bcells_Human1.48551485
38* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.47687127
39AR_25329375_ChIP-Seq_VCAP_Human1.46826796
40SMC4_20622854_ChIP-Seq_HELA_Human1.46237137
41SMAD4_21741376_ChIP-Seq_EPCs_Human1.45999241
42ETV2_25802403_ChIP-Seq_MESCs_Mouse1.45489631
43E2F1_20622854_ChIP-Seq_HELA_Human1.44887003
44OCT4_20526341_ChIP-Seq_ESCs_Human1.42757603
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42514082
46AUTS2_25519132_ChIP-Seq_293T-REX_Human1.41945855
47CBX2_22325352_ChIP-Seq_293T-Rex_Human1.41728867
48RBPJ_21746931_ChIP-Seq_IB4_Human1.41178129
49TP63_22573176_ChIP-Seq_HFKS_Human1.40666625
50PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.40385300
51HNFA_21074721_ChIP-Seq_CACO-2_Human1.39498710
52P68_20966046_ChIP-Seq_HELA_Human1.38916108
53PHF8_20622854_ChIP-Seq_HELA_Human1.38785181
54CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.36175196
55ERG_20517297_ChIP-Seq_VCAP_Human1.34864898
56TP53_18474530_ChIP-ChIP_U2OS_Human1.34097022
57ETV1_20927104_ChIP-Seq_GIST48_Human1.33630911
58P300_27268052_Chip-Seq_Bcells_Human1.30058475
59KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.29770034
60P300_19829295_ChIP-Seq_ESCs_Human1.29670901
61SOX2_22085726_ChIP-Seq_NPCs_Mouse1.26900375
62TAF15_26573619_Chip-Seq_HEK293_Human1.25852639
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.25701461
64GATA3_21878914_ChIP-Seq_MCF-7_Human1.24721065
65SUZ12_27294783_Chip-Seq_ESCs_Mouse1.24416701
66ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.22058395
67LXR_22292898_ChIP-Seq_THP-1_Human1.21640513
68NFYB_21822215_ChIP-Seq_K562_Human1.21476029
69TBL1_22424771_ChIP-Seq_293T_Human1.20901914
70SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.19712686
71* CEBPB_22108803_ChIP-Seq_LS180_Human1.19582973
72P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.17251599
73* SMAD3_21741376_ChIP-Seq_ESCs_Human1.16063213
74RUNX_20019798_ChIP-Seq_JUKART_Human1.14617808
75PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.14500851
76EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.14436088
77PHF8_20622853_ChIP-Seq_HELA_Human1.13788653
78RUNX1_26923725_Chip-Seq_HPCs_Mouse1.12476812
79TP63_19390658_ChIP-ChIP_HaCaT_Human1.12445435
80GATA6_21074721_ChIP-Seq_CACO-2_Human1.12006084
81TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11481397
82SA1_27219007_Chip-Seq_Bcells_Human1.11329793
83SMAD4_21741376_ChIP-Seq_HESCs_Human1.10630010
84ZNF274_21170338_ChIP-Seq_K562_Hela1.09814371
85P53_21459846_ChIP-Seq_SAOS-2_Human1.08525970
86TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08045828
87EZH2_27294783_Chip-Seq_ESCs_Mouse1.07870055
88PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.06739302
89KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04721689
90* SMRT_27268052_Chip-Seq_Bcells_Human1.04530385
91RUNX2_22187159_ChIP-Seq_PCA_Human1.04100989
92NFYA_21822215_ChIP-Seq_K562_Human1.03310107
93SMAD4_21799915_ChIP-Seq_A2780_Human1.03294738
94GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.01496102
95GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01315177
96SOX2_19829295_ChIP-Seq_ESCs_Human1.00385533
97NANOG_19829295_ChIP-Seq_ESCs_Human1.00385533
98STAT3_23295773_ChIP-Seq_U87_Human0.99289876
99OCT1_27270436_Chip-Seq_PROSTATE_Human0.99277356
100NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.97463073

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot5.17025676
2MP0003878_abnormal_ear_physiology5.17025676
3MP0005670_abnormal_white_adipose4.72758173
4MP0003698_abnormal_male_reproductive4.39498947
5MP0001929_abnormal_gametogenesis3.74943339
6MP0001348_abnormal_lacrimal_gland3.62979444
7MP0002161_abnormal_fertility/fecundity2.45613721
8MP0000678_abnormal_parathyroid_gland2.36889320
9MP0003718_maternal_effect2.16618958
10MP0003646_muscle_fatigue2.11040800
11MP0003011_delayed_dark_adaptation2.01007024
12MP0005410_abnormal_fertilization12.3988885
13MP0002132_abnormal_respiratory_system1.99517678
14MP0005379_endocrine/exocrine_gland_phen1.72036478
15MP0005423_abnormal_somatic_nervous1.67626376
16MP0001485_abnormal_pinna_reflex1.64998383
17MP0002210_abnormal_sex_determination1.61353108
18MP0001486_abnormal_startle_reflex1.59606222
19MP0005310_abnormal_salivary_gland1.56397033
20MP0003879_abnormal_hair_cell1.53430398
21MP0002822_catalepsy1.51943639
22MP0002234_abnormal_pharynx_morphology1.50006444
23MP0009053_abnormal_anal_canal1.44753888
24MP0002249_abnormal_larynx_morphology1.43185821
25MP0002735_abnormal_chemical_nociception1.38977868
26MP0001145_abnormal_male_reproductive1.32257746
27MP0002282_abnormal_trachea_morphology1.32019162
28MP0004742_abnormal_vestibular_system1.28233147
29MP0000653_abnormal_sex_gland1.25452313
30MP0000534_abnormal_ureter_morphology1.17888014
31MP0001968_abnormal_touch/_nociception1.16761135
32MP0004859_abnormal_synaptic_plasticity1.14231086
33MP0004510_myositis1.13998423
34MP0001963_abnormal_hearing_physiology1.11309862
35MP0005248_abnormal_Harderian_gland1.10514308
36MP0005451_abnormal_body_composition1.09160715
37MP0002127_abnormal_cardiovascular_syste1.08962215
38MP0002138_abnormal_hepatobiliary_system1.06303912
39MP0001765_abnormal_ion_homeostasis1.05474203
40MP0000026_abnormal_inner_ear0.97690058
41MP0005395_other_phenotype0.96091812
42MP0002229_neurodegeneration0.90423508
43MP0002733_abnormal_thermal_nociception0.89663054
44MP0001879_abnormal_lymphatic_vessel0.88343407
45MP0005666_abnormal_adipose_tissue0.87968455
46MP0009115_abnormal_fat_cell0.86604122
47MP0005551_abnormal_eye_electrophysiolog0.85542863
48MP0002067_abnormal_sensory_capabilities0.85021532
49MP0008877_abnormal_DNA_methylation0.84522734
50MP0000955_abnormal_spinal_cord0.84022600
51MP0004085_abnormal_heartbeat0.77354034
52MP0000681_abnormal_thyroid_gland0.77343445
53MP0002557_abnormal_social/conspecific_i0.74820822
54MP0005167_abnormal_blood-brain_barrier0.74341156
55MP0008569_lethality_at_weaning0.72656016
56MP0005375_adipose_tissue_phenotype0.65460253
57MP0005253_abnormal_eye_physiology0.64851478
58MP0004036_abnormal_muscle_relaxation0.64705251
59MP0005645_abnormal_hypothalamus_physiol0.63562884
60MP0001905_abnormal_dopamine_level0.63315237
61MP0000049_abnormal_middle_ear0.62208941
62MP0001970_abnormal_pain_threshold0.61238080
63MP0001501_abnormal_sleep_pattern0.61226034
64MP0001666_abnormal_nutrient_absorption0.60384295
65MP0002272_abnormal_nervous_system0.59242879
66MP0000516_abnormal_urinary_system0.58920506
67MP0005367_renal/urinary_system_phenotyp0.58920506
68MP0002572_abnormal_emotion/affect_behav0.58140403
69MP0004484_altered_response_of0.57818021
70MP0008961_abnormal_basal_metabolism0.57224583
71MP0005083_abnormal_biliary_tract0.56943270
72MP0000230_abnormal_systemic_arterial0.56425200
73MP0005623_abnormal_meninges_morphology0.56270462
74MP0005535_abnormal_body_temperature0.55330872
75MP0002734_abnormal_mechanical_nocicepti0.55227285
76MP0009745_abnormal_behavioral_response0.55013168
77MP0003137_abnormal_impulse_conducting0.51738847
78MP0009697_abnormal_copulation0.51396551
79MP0000249_abnormal_blood_vessel0.51037399
80MP0005084_abnormal_gallbladder_morpholo0.50508310
81MP0005636_abnormal_mineral_homeostasis0.49946592
82MP0004233_abnormal_muscle_weight0.48441584
83MP0006276_abnormal_autonomic_nervous0.47192327
84MP0004084_abnormal_cardiac_muscle0.45714651
85MP0010329_abnormal_lipoprotein_level0.43964420
86MP0001440_abnormal_grooming_behavior0.43598739
87MP0003077_abnormal_cell_cycle0.42381317
88MP0003119_abnormal_digestive_system0.42111479
89MP0000003_abnormal_adipose_tissue0.39948182
90MP0003635_abnormal_synaptic_transmissio0.39550922
91MP0005647_abnormal_sex_gland0.39181979
92MP0003880_abnormal_central_pattern0.36534178
93MP0000613_abnormal_salivary_gland0.36408862
94MP0003699_abnormal_female_reproductive0.36135699
95MP0009764_decreased_sensitivity_to0.35289139
96MP0002882_abnormal_neuron_morphology0.33350387
97MP0003631_nervous_system_phenotype0.33234890
98MP0000470_abnormal_stomach_morphology0.32894472
99MP0002653_abnormal_ependyma_morphology0.31271790
100MP0003638_abnormal_response/metabolism_0.29758075

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)7.84019522
2Dynein arm defect of respiratory motile cilia (HP:0012255)6.68496611
3Absent/shortened dynein arms (HP:0200106)6.68496611
4Tubulointerstitial nephritis (HP:0001970)5.59302022
5Asymmetric septal hypertrophy (HP:0001670)5.29201759
6Abnormal ciliary motility (HP:0012262)5.01358462
7Chronic hepatic failure (HP:0100626)4.98288962
8Attenuation of retinal blood vessels (HP:0007843)4.82121393
9Abnormal respiratory motile cilium physiology (HP:0012261)4.79474614
10Bony spicule pigmentary retinopathy (HP:0007737)4.76354821
11Abnormal respiratory epithelium morphology (HP:0012253)4.72731360
12Abnormal respiratory motile cilium morphology (HP:0005938)4.72731360
13Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.57748010
14Hyperkalemia (HP:0002153)4.48452619
15Nasal polyposis (HP:0100582)4.46858498
16Resting tremor (HP:0002322)4.38303051
17Infertility (HP:0000789)4.24941165
18Male infertility (HP:0003251)4.21973043
19Abnormality of macular pigmentation (HP:0008002)3.99942760
20Cone-rod dystrophy (HP:0000548)3.88678667
21Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.88581741
22Potter facies (HP:0002009)3.84761260
23Facial shape deformation (HP:0011334)3.84761260
24Abnormality of the nasal mucosa (HP:0000433)3.63190210
25Aplasia/Hypoplasia of the earlobes (HP:0009906)3.63034974
26Abnormal rod and cone electroretinograms (HP:0008323)3.61899205
27Impulsivity (HP:0100710)3.34091691
28Bell-shaped thorax (HP:0001591)3.32319907
29Progressive cerebellar ataxia (HP:0002073)3.27568173
30Progressive sensorineural hearing impairment (HP:0000408)3.26313214
31Hypoplasia of the thymus (HP:0000778)3.25547797
32Hypoalphalipoproteinemia (HP:0003233)3.21435265
33Abnormal spermatogenesis (HP:0008669)3.19103880
34Hypoplastic ischia (HP:0003175)3.12961680
35Postural instability (HP:0002172)3.11454957
36Amelogenesis imperfecta (HP:0000705)3.06516673
37Azoospermia (HP:0000027)3.03663719
38Unilateral renal agenesis (HP:0000122)2.96478593
39Enlarged epiphyses (HP:0010580)2.89706076
40Menstrual irregularities (HP:0000858)2.88620300
41Generalized aminoaciduria (HP:0002909)2.79661175
42Abnormality of the ischium (HP:0003174)2.79161247
43Truncal obesity (HP:0001956)2.76945182
44Abnormality of dental color (HP:0011073)2.76804565
45Abnormal urine output (HP:0012590)2.75513560
46Stage 5 chronic kidney disease (HP:0003774)2.72684675
47Abnormality of the aortic arch (HP:0012303)2.72328204
48Rhinitis (HP:0012384)2.71772123
49Congenital malformation of the right heart (HP:0011723)2.67673582
50Double outlet right ventricle (HP:0001719)2.67673582
51Tubulointerstitial abnormality (HP:0001969)2.63240564
52Renovascular hypertension (HP:0100817)2.61199798
53Abnormality of potassium homeostasis (HP:0011042)2.59478517
54Portal hypertension (HP:0001409)2.56614136
55Renal dysplasia (HP:0000110)2.55360055
56Nephronophthisis (HP:0000090)2.55163999
57Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.51740232
58Insulin-resistant diabetes mellitus (HP:0000831)2.49667391
59Abnormality of the costochondral junction (HP:0000919)2.47731452
60Ventricular tachycardia (HP:0004756)2.41662922
61Abnormality of renal excretion (HP:0011036)2.38126352
62Abnormal drinking behavior (HP:0030082)2.34949853
63Polydipsia (HP:0001959)2.34949853
64Myokymia (HP:0002411)2.34731734
65Abnormality of the hepatic vasculature (HP:0006707)2.34051163
66Polyuria (HP:0000103)2.22790594
67Abnormality of the renal medulla (HP:0100957)2.17228115
68Abnormality of the parathyroid morphology (HP:0011766)2.16476830
69Bronchiectasis (HP:0002110)2.10137572
70Renal Fanconi syndrome (HP:0001994)2.08198644
71Hyponatremia (HP:0002902)2.07250910
72Osteomalacia (HP:0002749)2.04774843
73Progressive hearing impairment (HP:0001730)2.04664156
74Spastic paraparesis (HP:0002313)2.04259852
75Increased purine levels (HP:0004368)2.01304889
76Hyperuricemia (HP:0002149)2.01304889
77Hyperthyroidism (HP:0000836)2.00660437
78Focal segmental glomerulosclerosis (HP:0000097)1.98940863
79Hypophosphatemic rickets (HP:0004912)1.98160367
80Failure to thrive in infancy (HP:0001531)1.96885899
81Decreased central vision (HP:0007663)1.96167736
82Chronic bronchitis (HP:0004469)1.95953654
83Tetany (HP:0001281)1.94024685
84Upper limb muscle weakness (HP:0003484)1.93967479
85Intellectual disability, moderate (HP:0002342)1.88789706
86Optic nerve hypoplasia (HP:0000609)1.87450713
87Widely patent fontanelles and sutures (HP:0004492)1.86163081
88Flattened epiphyses (HP:0003071)1.82386727
89Recurrent corneal erosions (HP:0000495)1.80121151
90Subcapsular cataract (HP:0000523)1.79249463
91Bradycardia (HP:0001662)1.78585924
92Aplasia/Hypoplasia of the sacrum (HP:0008517)1.77288497
93Hypoparathyroidism (HP:0000829)1.76243548
94Transposition of the great arteries (HP:0001669)1.76105599
95Abnormal connection of the cardiac segments (HP:0011545)1.76105599
96Abnormal ventriculo-arterial connection (HP:0011563)1.76105599
97Recurrent pneumonia (HP:0006532)1.71131629
98Amblyopia (HP:0000646)1.70862412
99Neoplasm of the heart (HP:0100544)1.70776550
100Congenital sensorineural hearing impairment (HP:0008527)1.67913861

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK48.91393863
2TESK16.18868313
3DDR23.61380444
4INSRR3.53948333
5PNCK3.47695373
6PLK23.43736158
7BRD43.41899185
8STK383.10460533
9MAP4K23.06838158
10CAMK1G2.56399380
11MAPK152.32547219
12PRKD32.29800081
13PIK3CG2.04154797
14STK38L2.04116518
15PDPK11.73775769
16PDK11.65744491
17WNK11.52509759
18MAP3K111.46112864
19MST1R1.40655132
20PTK2B1.34054530
21NEK61.32970007
22DYRK1B1.32073122
23CDK121.29958557
24CDK71.12928093
25TYRO30.99478399
26SIK20.90469219
27MAP3K90.89686062
28CAMK1D0.87395740
29AKT30.83229834
30KSR20.81333577
31LATS20.76390552
32MARK10.72749686
33PRKG20.67905928
34WNK40.67878694
35PRKG10.63802786
36CAMK10.60547561
37UHMK10.59101712
38MAP2K20.58322625
39BRAF0.57441028
40RPS6KA20.57209613
41RPS6KA10.57089505
42PRKAA20.57045931
43STK390.55673955
44BMPR1B0.54455403
45RIPK40.53356698
46MAP3K40.51689162
47MAP3K10.51198969
48TIE10.50548258
49MAP3K20.48192275
50NTRK30.46276430
51ROCK10.45893446
52SGK2230.45318580
53SGK4940.45318580
54GSK3B0.45247972
55TESK20.42087657
56MAP3K80.40600701
57CDK30.40184724
58CDK10.39462013
59MAPK10.39133626
60CDK20.38179337
61MAPK80.36620372
62PRKCZ0.35981289
63SGK10.35903764
64TNIK0.34286316
65PRKCG0.33733101
66MUSK0.32159625
67MAP2K70.30693381
68CAMK40.29663785
69MTOR0.28237091
70LATS10.24974739
71CDK40.24685600
72MINK10.24440596
73PRKCB0.24035205
74MAPK140.24014438
75FRK0.23887001
76RPS6KL10.23411100
77RPS6KC10.23411100
78RPS6KA60.23118566
79CHEK10.21580841
80MAPK110.21125365
81PKN10.20374531
82MAP3K120.20173986
83BLK0.19060483
84TLK10.18872386
85MAPK100.17496108
86AKT10.17205159
87FER0.15599831
88ACVR1B0.15281927
89BRSK10.12527186
90PRKACB0.12133451
91PRKACA0.11349365
92SGK20.11074339
93ARAF0.11068413
94OXSR10.10970073
95ZAK0.10337524
96NEK20.09843094
97MAP2K40.08793919
98MAPK90.08724034
99CHUK0.07886757
100IKBKB0.07837217

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.18329561
2Fatty acid biosynthesis_Homo sapiens_hsa000616.78996465
3Olfactory transduction_Homo sapiens_hsa047403.83482133
4Butanoate metabolism_Homo sapiens_hsa006502.45150453
5Glycerophospholipid metabolism_Homo sapiens_hsa005642.04998266
6Taste transduction_Homo sapiens_hsa047421.96622799
7Type II diabetes mellitus_Homo sapiens_hsa049301.73811833
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.69974954
9Type I diabetes mellitus_Homo sapiens_hsa049401.69810970
10Allograft rejection_Homo sapiens_hsa053301.66936129
11Dorso-ventral axis formation_Homo sapiens_hsa043201.66008026
12Fatty acid degradation_Homo sapiens_hsa000711.63598509
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.63326492
14Autoimmune thyroid disease_Homo sapiens_hsa053201.62020575
15Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.54194574
16Graft-versus-host disease_Homo sapiens_hsa053321.54084273
17Fatty acid metabolism_Homo sapiens_hsa012121.50297981
18Antigen processing and presentation_Homo sapiens_hsa046121.48976335
19Phenylalanine metabolism_Homo sapiens_hsa003601.46798719
20RNA transport_Homo sapiens_hsa030131.39288119
21Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.36191632
22Cardiac muscle contraction_Homo sapiens_hsa042601.30189848
23Phototransduction_Homo sapiens_hsa047441.28424764
24Adipocytokine signaling pathway_Homo sapiens_hsa049201.24834899
25Arginine and proline metabolism_Homo sapiens_hsa003301.20481235
26Endocytosis_Homo sapiens_hsa041441.18006008
27Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.14303891
28Morphine addiction_Homo sapiens_hsa050321.12671760
29Viral myocarditis_Homo sapiens_hsa054161.11887178
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.10946905
31Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.08704065
32Synaptic vesicle cycle_Homo sapiens_hsa047211.05548842
33Salivary secretion_Homo sapiens_hsa049701.04292318
34PPAR signaling pathway_Homo sapiens_hsa033201.02280477
35Calcium signaling pathway_Homo sapiens_hsa040200.96680625
36Nicotine addiction_Homo sapiens_hsa050330.93180245
37Circadian entrainment_Homo sapiens_hsa047130.89983346
38Fat digestion and absorption_Homo sapiens_hsa049750.89874923
39Protein digestion and absorption_Homo sapiens_hsa049740.87458286
40Glycerolipid metabolism_Homo sapiens_hsa005610.84331424
41Renin-angiotensin system_Homo sapiens_hsa046140.84174307
42cAMP signaling pathway_Homo sapiens_hsa040240.83599682
43Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82931190
44Inositol phosphate metabolism_Homo sapiens_hsa005620.82021772
45Glutamatergic synapse_Homo sapiens_hsa047240.75824149
46Serotonergic synapse_Homo sapiens_hsa047260.74765802
47Tyrosine metabolism_Homo sapiens_hsa003500.73908499
48Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.73835871
49ABC transporters_Homo sapiens_hsa020100.73484118
50Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70319037
51Influenza A_Homo sapiens_hsa051640.70020015
52Primary bile acid biosynthesis_Homo sapiens_hsa001200.69548629
53Arginine biosynthesis_Homo sapiens_hsa002200.65252647
54Hedgehog signaling pathway_Homo sapiens_hsa043400.65101810
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64445096
56Renin secretion_Homo sapiens_hsa049240.63729781
57Oocyte meiosis_Homo sapiens_hsa041140.62698345
58Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.62094798
59Nitrogen metabolism_Homo sapiens_hsa009100.61344042
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.60007775
61Estrogen signaling pathway_Homo sapiens_hsa049150.59573275
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.59061523
63Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57391791
64Vascular smooth muscle contraction_Homo sapiens_hsa042700.56852051
65Pancreatic secretion_Homo sapiens_hsa049720.56492480
66Retinol metabolism_Homo sapiens_hsa008300.54709696
67GABAergic synapse_Homo sapiens_hsa047270.53855116
68MAPK signaling pathway_Homo sapiens_hsa040100.51871211
69Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.50302396
70Gastric acid secretion_Homo sapiens_hsa049710.50267715
71Vitamin B6 metabolism_Homo sapiens_hsa007500.49807962
72Aldosterone synthesis and secretion_Homo sapiens_hsa049250.47484271
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46475558
74Huntingtons disease_Homo sapiens_hsa050160.44509772
75Purine metabolism_Homo sapiens_hsa002300.43314381
76Insulin secretion_Homo sapiens_hsa049110.43186484
77Cholinergic synapse_Homo sapiens_hsa047250.43080346
78Bile secretion_Homo sapiens_hsa049760.41262433
79VEGF signaling pathway_Homo sapiens_hsa043700.39063151
80Tight junction_Homo sapiens_hsa045300.37613896
81ECM-receptor interaction_Homo sapiens_hsa045120.35527889
82Oxytocin signaling pathway_Homo sapiens_hsa049210.33974759
83Acute myeloid leukemia_Homo sapiens_hsa052210.32457985
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29168910
85cGMP-PKG signaling pathway_Homo sapiens_hsa040220.28374072
86Alcoholism_Homo sapiens_hsa050340.28190068
87Basal transcription factors_Homo sapiens_hsa030220.27385626
88Platelet activation_Homo sapiens_hsa046110.25978596
89Long-term potentiation_Homo sapiens_hsa047200.25361837
90Linoleic acid metabolism_Homo sapiens_hsa005910.24151937
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.23559155
92Viral carcinogenesis_Homo sapiens_hsa052030.22134715
93Amphetamine addiction_Homo sapiens_hsa050310.19156395
94Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.18569751
95Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.16941124
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.16141706
97Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.15825426
98Chemokine signaling pathway_Homo sapiens_hsa040620.15506831
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.14066482
100Jak-STAT signaling pathway_Homo sapiens_hsa046300.13255418

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