PROB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)7.10124294
2muscle filament sliding (GO:0030049)6.50675153
3actin-myosin filament sliding (GO:0033275)6.50675153
4cardiac myofibril assembly (GO:0055003)6.07954921
5negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.04341369
6myofibril assembly (GO:0030239)5.98327227
7regulation of skeletal muscle contraction (GO:0014819)5.84461239
8skeletal muscle fiber development (GO:0048741)5.83270488
9plasma membrane repair (GO:0001778)5.46734533
10negative regulation of potassium ion transmembrane transport (GO:1901380)5.46212610
11actin-mediated cell contraction (GO:0070252)5.44971811
12positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.26787217
13myotube cell development (GO:0014904)5.14650943
14carnitine shuttle (GO:0006853)5.14640628
15tricarboxylic acid cycle (GO:0006099)5.06129606
16sarcoplasmic reticulum calcium ion transport (GO:0070296)5.05301514
17cardiac muscle contraction (GO:0060048)4.96994999
18positive regulation of myotube differentiation (GO:0010831)4.95960500
19creatine metabolic process (GO:0006600)4.94903214
20regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.94265985
21regulation of actin filament-based movement (GO:1903115)4.66295579
22fatty acid transmembrane transport (GO:1902001)4.59636118
23regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.56869109
24actomyosin structure organization (GO:0031032)4.56141414
25regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.55625029
26striated muscle contraction (GO:0006941)4.49701691
27aspartate family amino acid catabolic process (GO:0009068)4.47372166
28response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.46161126
29glucan catabolic process (GO:0009251)4.45728497
30muscle fiber development (GO:0048747)4.45565269
31cardiac muscle cell development (GO:0055013)4.45173565
32ventricular cardiac muscle cell action potential (GO:0086005)4.42540542
33glycogen biosynthetic process (GO:0005978)4.42084888
34glucan biosynthetic process (GO:0009250)4.42084888
35skeletal muscle tissue development (GO:0007519)4.38959009
362-oxoglutarate metabolic process (GO:0006103)4.38791927
37regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.38199446
38regulation of relaxation of muscle (GO:1901077)4.36103199
39lysine catabolic process (GO:0006554)4.35515314
40lysine metabolic process (GO:0006553)4.35515314
41bundle of His cell to Purkinje myocyte communication (GO:0086069)4.30753882
42adult heart development (GO:0007512)4.24302678
43skeletal muscle contraction (GO:0003009)4.17690481
44cardiac cell development (GO:0055006)4.15871866
45regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.15461485
46cellular polysaccharide catabolic process (GO:0044247)4.15349253
47actin filament-based movement (GO:0030048)4.11855487
48carnitine transmembrane transport (GO:1902603)4.07123733
49cardiac muscle tissue morphogenesis (GO:0055008)4.05255838
50carnitine transport (GO:0015879)4.04939944
51amino-acid betaine transport (GO:0015838)4.04939944
52cardiac muscle adaptation (GO:0014887)4.03238814
53cardiac muscle hypertrophy in response to stress (GO:0014898)4.03238814
54muscle hypertrophy in response to stress (GO:0003299)4.03238814
55regulation of cell communication by electrical coupling (GO:0010649)4.00638584
56regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.97224261
57muscle cell fate commitment (GO:0042693)3.96768421
58regulation of acyl-CoA biosynthetic process (GO:0050812)3.96317160
59fatty acid beta-oxidation (GO:0006635)3.91230759
60muscle cell cellular homeostasis (GO:0046716)3.90331904
61heart trabecula formation (GO:0060347)3.85227674
62muscle adaptation (GO:0043500)3.84188884
63muscle organ development (GO:0007517)3.84170919
64regulation of striated muscle contraction (GO:0006942)3.82159341
65regulation of sarcomere organization (GO:0060297)3.81459881
66cardiac muscle hypertrophy (GO:0003300)3.81359583
67muscle structure development (GO:0061061)3.79464173
68skeletal muscle tissue regeneration (GO:0043403)3.76201490
69muscle organ morphogenesis (GO:0048644)3.73996821
70muscle tissue morphogenesis (GO:0060415)3.73646232
71striated muscle cell development (GO:0055002)3.71265718
72ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.70160702
73muscle atrophy (GO:0014889)3.69104981
74gluconeogenesis (GO:0006094)3.68555543
75striated muscle hypertrophy (GO:0014897)3.67797385
76polysaccharide catabolic process (GO:0000272)3.67522882
77regulation of myotube differentiation (GO:0010830)3.62474857
78regulation of membrane repolarization (GO:0060306)3.62249611
79acetyl-CoA metabolic process (GO:0006084)3.60571722
80negative regulation of protein localization to cell surface (GO:2000009)3.59836695
81negative regulation of necroptotic process (GO:0060546)3.54816878
82regulation of cofactor metabolic process (GO:0051193)3.54447310
83regulation of coenzyme metabolic process (GO:0051196)3.54447310
84glycogen metabolic process (GO:0005977)3.52628595
85regulation of myoblast differentiation (GO:0045661)3.51641625
86fructose metabolic process (GO:0006000)3.50989225
87regulation of calcium ion transmembrane transport (GO:1903169)3.50669588
88regulation of calcium ion transmembrane transporter activity (GO:1901019)3.50669588
89cell communication involved in cardiac conduction (GO:0086065)3.50475082
90regulation of sequestering of triglyceride (GO:0010889)3.47200207
91cellular glucan metabolic process (GO:0006073)3.45023182
92glucan metabolic process (GO:0044042)3.45023182
93skeletal muscle adaptation (GO:0043501)3.44601747
94response to inactivity (GO:0014854)3.43334932
95short-chain fatty acid metabolic process (GO:0046459)3.40859457
96mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.40270715
97negative regulation of cell size (GO:0045792)3.40196813
98cellular ketone body metabolic process (GO:0046950)3.39471115
99cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.38485020
100heart contraction (GO:0060047)3.37749876
101heart process (GO:0003015)3.37749876
102fatty acid catabolic process (GO:0009062)3.36262611
103hexose biosynthetic process (GO:0019319)3.33628698
104negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.32862351
105quaternary ammonium group transport (GO:0015697)3.32156653
106fatty acid oxidation (GO:0019395)3.31439367
107cell-substrate adherens junction assembly (GO:0007045)3.28674484
108focal adhesion assembly (GO:0048041)3.28674484
109NADH metabolic process (GO:0006734)3.28609122
110skeletal muscle cell differentiation (GO:0035914)3.28053743
111branched-chain amino acid catabolic process (GO:0009083)3.27231874
112regulation of the force of heart contraction (GO:0002026)3.25306634
113lipid oxidation (GO:0034440)3.25185066
114muscle cell development (GO:0055001)3.24647124
115myoblast fusion (GO:0007520)3.23769931
116muscle contraction (GO:0006936)3.23646469
117positive regulation of myoblast differentiation (GO:0045663)3.19069730
118muscle hypertrophy (GO:0014896)3.18735899
119regulation of skeletal muscle fiber development (GO:0048742)3.18721425
120positive regulation of cation channel activity (GO:2001259)3.18270516
121respiratory electron transport chain (GO:0022904)3.18153801
122positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.16269483
123response to activity (GO:0014823)3.16066174
124regulation of fatty acid oxidation (GO:0046320)3.15386985
125mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.12853668
126striated muscle tissue development (GO:0014706)3.10736914
127regulation of cardiac muscle cell contraction (GO:0086004)3.10144401
128regulation of muscle system process (GO:0090257)3.09708068
129glycogen catabolic process (GO:0005980)3.09602191
130electron transport chain (GO:0022900)3.08597094
131branched-chain amino acid metabolic process (GO:0009081)3.07960290
132oxaloacetate metabolic process (GO:0006107)3.06913905
133regulation of muscle contraction (GO:0006937)3.05759018
134regulation of skeletal muscle cell differentiation (GO:2001014)3.04915716
135striated muscle adaptation (GO:0014888)3.04462055
136response to muscle activity (GO:0014850)3.04383415
137response to mercury ion (GO:0046689)3.01650029
138tricarboxylic acid metabolic process (GO:0072350)3.00460375
139muscle system process (GO:0003012)2.98183352
140regulation of cardiac muscle contraction (GO:0055117)2.98098848
141glyoxylate metabolic process (GO:0046487)2.96721484
142cardiac muscle cell action potential involved in contraction (GO:0086002)2.96701011
143regulation of sulfur metabolic process (GO:0042762)2.95968353
144cardiac muscle cell action potential (GO:0086001)2.94471299
145monocarboxylic acid catabolic process (GO:0072329)2.93325735
146striated muscle atrophy (GO:0014891)2.92625251
147ATP synthesis coupled proton transport (GO:0015986)2.91347017
148energy coupled proton transport, down electrochemical gradient (GO:0015985)2.91347017
149ketone body metabolic process (GO:1902224)2.90905383

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.32285534
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.45530120
3MYC_22102868_ChIP-Seq_BL_Human3.23506769
4EP300_21415370_ChIP-Seq_HL-1_Mouse3.17685798
5RXR_22158963_ChIP-Seq_LIVER_Mouse3.15000907
6PPARA_22158963_ChIP-Seq_LIVER_Mouse2.97306059
7TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.94451646
8ESR1_20079471_ChIP-ChIP_T-47D_Human2.89861492
9TBX20_22080862_ChIP-Seq_HEART_Mouse2.88337937
10TBX20_22328084_ChIP-Seq_HEART_Mouse2.88337937
11VDR_21846776_ChIP-Seq_THP-1_Human2.86490245
12LXR_22158963_ChIP-Seq_LIVER_Mouse2.85170159
13ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.81226512
14NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.49071662
15TCF7_22412390_ChIP-Seq_EML_Mouse2.33602095
16ZNF263_19887448_ChIP-Seq_K562_Human2.23669931
17FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.21272559
18KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.21077541
19BCL3_23251550_ChIP-Seq_MUSCLE_Mouse2.12118092
20PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.11175314
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.08497784
22RARG_19884340_ChIP-ChIP_MEFs_Mouse2.04375869
23RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.96189931
24ESR2_21235772_ChIP-Seq_MCF-7_Human1.93020607
25ELK3_25401928_ChIP-Seq_HUVEC_Human1.78767129
26MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.74327627
27CTCF_27219007_Chip-Seq_ERYTHROID_Human1.72374634
28CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.71983220
29MAF_26560356_Chip-Seq_TH1_Human1.68065227
30KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.63745502
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.62701333
32CDX2_19796622_ChIP-Seq_MESCs_Mouse1.62252174
33ZFP281_18757296_ChIP-ChIP_E14_Mouse1.58226396
34CLOCK_20551151_ChIP-Seq_293T_Human1.56846860
35RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.50748376
36STAT3_1855785_ChIP-Seq_MESCs_Mouse1.50463130
37EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.49893195
38ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.49733102
39CTCF_21964334_ChIP-Seq_BJAB-B_Human1.49698934
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49238893
41SA1_27219007_Chip-Seq_ERYTHROID_Human1.46450131
42TET1_21451524_ChIP-Seq_MESCs_Mouse1.46324401
43EZH2_22144423_ChIP-Seq_EOC_Human1.45605125
44CTCF_21964334_Chip-Seq_Bcells_Human1.42317176
45MAF_26560356_Chip-Seq_TH2_Human1.41348272
46TP63_17297297_ChIP-ChIP_HaCaT_Human1.39940995
47FOXA2_19822575_ChIP-Seq_HepG2_Human1.36907252
48EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.34989714
49MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.34745951
50CTCF_27219007_Chip-Seq_Bcells_Human1.34069599
51E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.30486074
52CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.29969709
53VDR_24763502_ChIP-Seq_THP-1_Human1.29658215
54PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.29656785
55TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.28797828
56DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.28297309
57SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.28075126
58GATA1_19941827_ChIP-Seq_MEL_Mouse1.26675494
59KDM2B_26808549_Chip-Seq_JURKAT_Human1.26251407
60BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.26241846
61DROSHA_22980978_ChIP-Seq_HELA_Human1.25881013
62STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.24738209
63BP1_19119308_ChIP-ChIP_Hs578T_Human1.22017509
64TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20866003
65ERG_21242973_ChIP-ChIP_JURKAT_Human1.20357547
66PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.17768572
67SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.14676778
68WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.12951672
69KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12666410
70UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.12161247
71ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.12005775
72ELF1_20517297_ChIP-Seq_JURKAT_Human1.09504153
73UTX_26944678_Chip-Seq_JUKART_Human1.08530666
74CTCF_26484167_Chip-Seq_Bcells_Mouse1.08003514
75PPAR_26484153_Chip-Seq_NCI-H1993_Human1.07605602
76STAT6_21828071_ChIP-Seq_BEAS2B_Human1.07333174
77GATA4_21415370_ChIP-Seq_HL-1_Mouse1.06968866
78LXR_22292898_ChIP-Seq_THP-1_Human1.06861954
79GATA1_19941826_ChIP-Seq_K562_Human1.06324043
80BCOR_27268052_Chip-Seq_Bcells_Human1.05433989
81TP63_22573176_ChIP-Seq_HFKS_Human1.03938899
82ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.03681128
83RACK7_27058665_Chip-Seq_MCF-7_Human1.03565378
84RARB_27405468_Chip-Seq_BRAIN_Mouse1.02907694
85UBF1/2_26484160_Chip-Seq_HMECs_Human1.02253359
86TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.01858738
87PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.01430827
88MYC_27129775_Chip-Seq_CORNEA_Mouse1.01308657
89ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00233513
90ATF3_27146783_Chip-Seq_COLON_Human0.99677957
91SPI1_20517297_ChIP-Seq_HL60_Human0.99331236
92TRIM28_21343339_ChIP-Seq_HEK293_Human0.99208749
93SOX9_24532713_ChIP-Seq_HFSC_Mouse0.99202376
94ETS1_21867929_ChIP-Seq_TH2_Mouse0.98745073
95MTF2_20144788_ChIP-Seq_MESCs_Mouse0.98704389
96TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.97850273
97FOXO3_23340844_ChIP-Seq_DLD1_Human0.97786220
98ESR1_21235772_ChIP-Seq_MCF-7_Human0.97728126
99GATA1_22383799_ChIP-Seq_G1ME_Mouse0.96165155
100CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.95674000
101SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95432489
102KDM2B_26808549_Chip-Seq_SUP-B15_Human0.93757015
103EZH2_27294783_Chip-Seq_ESCs_Mouse0.93445477
104AUTS2_25519132_ChIP-Seq_293T-REX_Human0.92531040
105SOX2_27498859_Chip-Seq_STOMACH_Mouse0.92350568
106RUNX1_27514584_Chip-Seq_MCF-7_Human0.90442656
107SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.90442101
108ISL1_27105846_Chip-Seq_CPCs_Mouse0.90036880
109EGR1_23403033_ChIP-Seq_LIVER_Mouse0.89100799
110AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.89047199
111FOXH1_21741376_ChIP-Seq_ESCs_Human0.88245137
112SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.88199177
113OCT4_20526341_ChIP-Seq_ESCs_Human0.88130747
114DNAJC2_21179169_ChIP-ChIP_NT2_Human0.87764648
115P68_20966046_ChIP-Seq_HELA_Human0.87742055
116WT1_25993318_ChIP-Seq_PODOCYTE_Human0.87337777
117P63_26484246_Chip-Seq_KERATINOCYTES_Human0.86881002
118NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.86702453
119KDM2B_26808549_Chip-Seq_DND41_Human0.84436029
120NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.83394678
121P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.82331976
122KDM2B_26808549_Chip-Seq_K562_Human0.82068788
123SMAD4_21741376_ChIP-Seq_HESCs_Human0.81576003
124CREB1_26743006_Chip-Seq_LNCaP_Human0.81087155
125TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.80639758
126CBP_21632823_ChIP-Seq_H3396_Human0.80251765
127EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.79334602
128KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.79332531
129SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.78365766
130RNF2_18974828_ChIP-Seq_MESCs_Mouse0.77415711
131EZH2_18974828_ChIP-Seq_MESCs_Mouse0.77415711
132SMAD3_21741376_ChIP-Seq_HESCs_Human0.76964887
133SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.76347361
134GATA2_21666600_ChIP-Seq_HMVEC_Human0.76346630
135NFIB_24661679_ChIP-Seq_LUNG_Mouse0.75677689
136MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.75651347
137GATA2_19941826_ChIP-Seq_K562_Human0.75318535
138SA1_27219007_Chip-Seq_Bcells_Human0.74271291
139SUZ12_27294783_Chip-Seq_ESCs_Mouse0.73004353
140AHR_22903824_ChIP-Seq_MCF-7_Human0.72282831
141SMC4_20622854_ChIP-Seq_HELA_Human0.72153470
142SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.71678333
143P300_27058665_Chip-Seq_ZR-75-30cells_Human0.71333277
144CJUN_26792858_Chip-Seq_BT549_Human0.70811694
145SMC3_22415368_ChIP-Seq_MEFs_Mouse0.70225087
146NRF2_20460467_ChIP-Seq_MEFs_Mouse0.70073248
147NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.70073248

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.96177220
2MP0003646_muscle_fatigue5.38632471
3MP0000751_myopathy4.92782596
4MP0004084_abnormal_cardiac_muscle4.40253789
5MP0000749_muscle_degeneration4.08597256
6MP0004036_abnormal_muscle_relaxation4.00510650
7MP0004215_abnormal_myocardial_fiber3.61882067
8MP0005330_cardiomyopathy3.33823630
9MP0004087_abnormal_muscle_fiber2.97643564
10MP0004145_abnormal_muscle_electrophysio2.96836063
11MP0000747_muscle_weakness2.63404101
12MP0004130_abnormal_muscle_cell2.62734622
13MP0000750_abnormal_muscle_regeneration2.61545529
14MP0002106_abnormal_muscle_physiology2.59381052
15MP0005620_abnormal_muscle_contractility2.58178074
16MP0002972_abnormal_cardiac_muscle2.50582677
17MP0002269_muscular_atrophy2.46439514
18MP0003137_abnormal_impulse_conducting2.25909195
19MP0008775_abnormal_heart_ventricle2.23613814
20MP0000759_abnormal_skeletal_muscle2.16222227
21MP0005369_muscle_phenotype2.13456612
22MP0010630_abnormal_cardiac_muscle2.11085699
23MP0004484_altered_response_of2.08077985
24MP0005385_cardiovascular_system_phenoty2.03488243
25MP0001544_abnormal_cardiovascular_syste2.03488243
26MP0003806_abnormal_nucleotide_metabolis1.99448062
27MP0005360_urolithiasis1.88297188
28MP0006138_congestive_heart_failure1.87891121
29MP0006036_abnormal_mitochondrial_physio1.87230648
30MP0004233_abnormal_muscle_weight1.79189670
31MP0003950_abnormal_plasma_membrane1.78313113
32MP0002139_abnormal_hepatobiliary_system1.76367289
33MP0004043_abnormal_pH_regulation1.74691260
34MP0005666_abnormal_adipose_tissue1.71255827
35MP0003221_abnormal_cardiomyocyte_apopto1.62735513
36MP0004085_abnormal_heartbeat1.62678516
37MP0004185_abnormal_adipocyte_glucose1.52880491
38MP0005085_abnormal_gallbladder_physiolo1.51109234
39MP0005451_abnormal_body_composition1.43830027
40MP0002332_abnormal_exercise_endurance1.36784025
41MP0001661_extended_life_span1.34742107
42MP0005670_abnormal_white_adipose1.27569351
43MP0003828_pulmonary_edema1.23895823
44MP0005365_abnormal_bile_salt1.20313019
45MP0003195_calcinosis1.16426619
46MP0005375_adipose_tissue_phenotype1.15121819
47MP0005332_abnormal_amino_acid1.14622646
48MP0002127_abnormal_cardiovascular_syste1.14485140
49MP0002234_abnormal_pharynx_morphology1.09671932
50MP0005083_abnormal_biliary_tract1.09610587
51MP0002108_abnormal_muscle_morphology1.08490121
52MP0009840_abnormal_foam_cell1.08187891
53MP0003252_abnormal_bile_duct1.01693214
54MP0008875_abnormal_xenobiotic_pharmacok1.00982928
55MP0010368_abnormal_lymphatic_system1.00324756
56MP0005165_increased_susceptibility_to0.99000701
57MP0004510_myositis0.96889319
58MP0006035_abnormal_mitochondrial_morpho0.90917154
59MP0005266_abnormal_metabolism0.89692651
60MP0002971_abnormal_brown_adipose0.88845927
61MP0000733_abnormal_muscle_development0.88453815
62MP0000230_abnormal_systemic_arterial0.87917423
63MP0002118_abnormal_lipid_homeostasis0.85926617
64MP0000266_abnormal_heart_morphology0.85605492
65MP0003705_abnormal_hypodermis_morpholog0.85241461
66MP0003045_fibrosis0.83377668
67MP0005319_abnormal_enzyme/_coenzyme0.79026503
68MP0000343_altered_response_to0.71515090
69MP0005623_abnormal_meninges_morphology0.71392364
70MP0005584_abnormal_enzyme/coenzyme_acti0.71152098
71MP0009643_abnormal_urine_homeostasis0.70577806
72MP0001346_abnormal_lacrimal_gland0.69647037
73MP0003567_abnormal_fetal_cardiomyocyte0.68846915
74MP0002078_abnormal_glucose_homeostasis0.67417489
75MP0000920_abnormal_myelination0.66937021
76MP0008961_abnormal_basal_metabolism0.64243141
77MP0010329_abnormal_lipoprotein_level0.62411238
78MP0002128_abnormal_blood_circulation0.62162485
79MP0001765_abnormal_ion_homeostasis0.62006311
80MP0002822_catalepsy0.59427177
81MP0000579_abnormal_nail_morphology0.58458873
82MP0000003_abnormal_adipose_tissue0.55879585
83MP0009780_abnormal_chondrocyte_physiolo0.55752311
84MP0005076_abnormal_cell_differentiation0.55288417
85MP0003329_amyloid_beta_deposits0.54915779
86MP0000013_abnormal_adipose_tissue0.52150938
87MP0005187_abnormal_penis_morphology0.51400446
88MP0004147_increased_porphyrin_level0.50131486
89MP0005535_abnormal_body_temperature0.49243592
90MP0009672_abnormal_birth_weight0.49191358
91MP0001666_abnormal_nutrient_absorption0.48089661
92MP0002138_abnormal_hepatobiliary_system0.47575477
93MP0002249_abnormal_larynx_morphology0.47360381
94MP0003191_abnormal_cellular_cholesterol0.46921876
95MP0003279_aneurysm0.46352015
96MP0001849_ear_inflammation0.45983378
97MP0004858_abnormal_nervous_system0.45524362
98MP0001879_abnormal_lymphatic_vessel0.45067606
99MP0005334_abnormal_fat_pad0.43832466
100MP0002909_abnormal_adrenal_gland0.43588456
101MP0003566_abnormal_cell_adhesion0.42979805
102MP0000762_abnormal_tongue_morphology0.42896568
103MP0004270_analgesia0.41878657
104MP0000609_abnormal_liver_physiology0.41524769
105MP0005275_abnormal_skin_tensile0.41391992
106MP0002114_abnormal_axial_skeleton0.40203542
107MP0002896_abnormal_bone_mineralization0.38318324
108MP0003948_abnormal_gas_homeostasis0.38075798
109MP0004197_abnormal_fetal_growth/weight/0.37825587
110MP0009384_cardiac_valve_regurgitation0.36620434
111MP0005551_abnormal_eye_electrophysiolog0.36268368
112MP0001299_abnormal_eye_distance/0.34958108
113MP0002166_altered_tumor_susceptibility0.34731374
114MP0004134_abnormal_chest_morphology0.34215840
115MP0000383_abnormal_hair_follicle0.34076218
116MP0010030_abnormal_orbit_morphology0.33776418
117MP0002796_impaired_skin_barrier0.33223640
118MP0002396_abnormal_hematopoietic_system0.32826217
119MP0003656_abnormal_erythrocyte_physiolo0.32770101
120MP0005636_abnormal_mineral_homeostasis0.32630712
121MP0003091_abnormal_cell_migration0.30928456
122MP0002009_preneoplasia0.30523831
123MP0004381_abnormal_hair_follicle0.30309945
124MP0003879_abnormal_hair_cell0.30188631
125MP0005409_darkened_coat_color0.30064966
126MP0003763_abnormal_thymus_physiology0.30005307
127MP0005452_abnormal_adipose_tissue0.29837999
128MP0001873_stomach_inflammation0.28446124
129MP0000767_abnormal_smooth_muscle0.27940607
130MP0010234_abnormal_vibrissa_follicle0.27743001
131MP0008569_lethality_at_weaning0.27311557
132MP0000678_abnormal_parathyroid_gland0.26572502
133MP0009115_abnormal_fat_cell0.26125165
134MP0005166_decreased_susceptibility_to0.24814675
135MP0005376_homeostasis/metabolism_phenot0.23443616
136MP0002925_abnormal_cardiovascular_devel0.23235384
137MP0003984_embryonic_growth_retardation0.22805822

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)6.57875666
2Sudden death (HP:0001699)6.31748960
3Calf muscle hypertrophy (HP:0008981)6.21518931
4Muscle fiber splitting (HP:0003555)6.13487352
5Exercise-induced muscle cramps (HP:0003710)6.09576149
6Muscle hypertrophy of the lower extremities (HP:0008968)6.01350305
7Hyporeflexia of lower limbs (HP:0002600)5.41193600
8Ventricular tachycardia (HP:0004756)5.26154537
9Myoglobinuria (HP:0002913)5.01536219
10Centrally nucleated skeletal muscle fibers (HP:0003687)4.92444311
11Abnormality of the calf musculature (HP:0001430)4.89005881
12Muscle fiber inclusion bodies (HP:0100299)4.48613488
13Difficulty running (HP:0009046)4.41607771
14Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.32512918
15EMG: myopathic abnormalities (HP:0003458)4.26804279
16Atrial fibrillation (HP:0005110)4.25922585
17Calcaneovalgus deformity (HP:0001848)4.23442732
18Abnormality of the left ventricular outflow tract (HP:0011103)4.08147602
19Subaortic stenosis (HP:0001682)4.08147602
20Right ventricular cardiomyopathy (HP:0011663)4.05100885
21Lipoatrophy (HP:0100578)3.96884345
22Primary atrial arrhythmia (HP:0001692)3.93886746
23Supraventricular tachycardia (HP:0004755)3.77463784
24Increased connective tissue (HP:0009025)3.77123573
25Rhabdomyolysis (HP:0003201)3.72339611
26Type 1 muscle fiber predominance (HP:0003803)3.71986845
27Deformed tarsal bones (HP:0008119)3.69494394
28Supraventricular arrhythmia (HP:0005115)3.69024618
29Nemaline bodies (HP:0003798)3.66038312
30Asymmetric septal hypertrophy (HP:0001670)3.60453928
31Syncope (HP:0001279)3.52176847
32Bundle branch block (HP:0011710)3.51652609
33Dilated cardiomyopathy (HP:0001644)3.50988392
34Malignant hyperthermia (HP:0002047)3.47114622
35Absent phalangeal crease (HP:0006109)3.46183891
36Ketoacidosis (HP:0001993)3.43167102
37Palpitations (HP:0001962)3.33755462
38Prolonged QT interval (HP:0001657)3.24327873
39Myotonia (HP:0002486)3.23354435
40Muscle stiffness (HP:0003552)3.12013477
41Ketosis (HP:0001946)3.03650953
42Ventricular arrhythmia (HP:0004308)3.03218348
43Frequent falls (HP:0002359)3.00640501
44Heart block (HP:0012722)2.99270988
45Difficulty climbing stairs (HP:0003551)2.99255739
46Atrioventricular block (HP:0001678)2.84786369
47Progressive muscle weakness (HP:0003323)2.84616764
48Abnormal finger flexion creases (HP:0006143)2.82181963
49Abnormal atrioventricular conduction (HP:0005150)2.80188888
50Bulbar palsy (HP:0001283)2.78114703
51Fetal akinesia sequence (HP:0001989)2.78089815
52Abnormality of fatty-acid metabolism (HP:0004359)2.77296887
53Increased variability in muscle fiber diameter (HP:0003557)2.75027990
54Ventricular fibrillation (HP:0001663)2.73979805
55Hypoglycemic coma (HP:0001325)2.72755261
56Abnormality of the calcaneus (HP:0008364)2.66298999
57Abnormality of skeletal muscle fiber size (HP:0012084)2.62143228
58Distal arthrogryposis (HP:0005684)2.62003694
59Neck muscle weakness (HP:0000467)2.59548142
60Round ear (HP:0100830)2.55723512
61Abnormality of dicarboxylic acid metabolism (HP:0010995)2.48975809
62Dicarboxylic aciduria (HP:0003215)2.48975809
63Myopathic facies (HP:0002058)2.47055965
64Gout (HP:0001997)2.42294931
65Weak cry (HP:0001612)2.41221846
66Fatigable weakness (HP:0003473)2.40393056
67Abnormality of the neuromuscular junction (HP:0003398)2.40393056
68Distal lower limb muscle weakness (HP:0009053)2.39934310
69Areflexia of lower limbs (HP:0002522)2.39843796
70Hyperglycinuria (HP:0003108)2.37529154
71Ragged-red muscle fibers (HP:0003200)2.34175950
72Slender build (HP:0001533)2.30729157
73Gowers sign (HP:0003391)2.30434067
74Central scotoma (HP:0000603)2.28181904
75Spinal rigidity (HP:0003306)2.27035928
76Hip contracture (HP:0003273)2.26395516
77Popliteal pterygium (HP:0009756)2.26259701
78Hepatic necrosis (HP:0002605)2.22557113
79Hyperammonemia (HP:0001987)2.22376470
80Abnormality of serine family amino acid metabolism (HP:0010894)2.21840162
81Abnormality of glycine metabolism (HP:0010895)2.21840162
82Cerebral edema (HP:0002181)2.20280478
83EMG: neuropathic changes (HP:0003445)2.17540727
84Acute encephalopathy (HP:0006846)2.17320491
85Left ventricular hypertrophy (HP:0001712)2.16856717
86Lower limb amyotrophy (HP:0007210)2.14220494
87Limb-girdle muscle atrophy (HP:0003797)2.13822406
88Abnormal EKG (HP:0003115)2.13554593
89Increased muscle lipid content (HP:0009058)2.11653296
90Palmoplantar keratoderma (HP:0000982)2.11352758
91Abnormal mitochondria in muscle tissue (HP:0008316)2.11123483
92Rimmed vacuoles (HP:0003805)2.09980482
93Ulnar deviation of the wrist (HP:0003049)2.09610442
94Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.07917136
95Hypoplastic ischia (HP:0003175)2.06599641
96Generalized muscle weakness (HP:0003324)2.05997435
97Acute necrotizing encephalopathy (HP:0006965)2.04491490
98Hyperinsulinemic hypoglycemia (HP:0000825)1.99257105
99Muscular dystrophy (HP:0003560)1.98700054
100Abnormality of the shoulder girdle musculature (HP:0001435)1.98202836
101Foot dorsiflexor weakness (HP:0009027)1.97390542
102Abnormality of the foot musculature (HP:0001436)1.96443116
103Hyperkalemia (HP:0002153)1.95595016
104Metatarsus adductus (HP:0001840)1.95359231
105Conjunctival hamartoma (HP:0100780)1.95167308
106Cholelithiasis (HP:0001081)1.94665585
107Waddling gait (HP:0002515)1.93641549
108Scapular winging (HP:0003691)1.92340676
109Hyperuricemia (HP:0002149)1.87741031
110Increased purine levels (HP:0004368)1.87741031
111Mildly elevated creatine phosphokinase (HP:0008180)1.87694481
112Large for gestational age (HP:0001520)1.86911871
113Testicular atrophy (HP:0000029)1.86578031
114Metabolic acidosis (HP:0001942)1.86099183
115Abnormality of the ischium (HP:0003174)1.83521077
116Abnormal gallbladder morphology (HP:0012437)1.82656797
117Distal lower limb amyotrophy (HP:0008944)1.80318626
118Pheochromocytoma (HP:0002666)1.78950049
119Hepatocellular necrosis (HP:0001404)1.77928758
120Increased intramyocellular lipid droplets (HP:0012240)1.77499425
121Easy fatigability (HP:0003388)1.77074431
122Facial diplegia (HP:0001349)1.75716104
123Proximal amyotrophy (HP:0007126)1.72615479
124Generalized aminoaciduria (HP:0002909)1.70022596
125Respiratory insufficiency due to muscle weakness (HP:0002747)1.69254097
126Long clavicles (HP:0000890)1.62674642
127Abnormality of placental membranes (HP:0011409)1.59855772
128Amniotic constriction ring (HP:0009775)1.59855772
129Limb-girdle muscle weakness (HP:0003325)1.59183818
130Paralysis (HP:0003470)1.54469628
131Exercise intolerance (HP:0003546)1.51638772
132Ulnar deviation of finger (HP:0009465)1.51617454
133Aplasia of the musculature (HP:0100854)1.51419280
134Generalized amyotrophy (HP:0003700)1.49698129
135Congenital hip dislocation (HP:0001374)1.49674567
136Dysmetric saccades (HP:0000641)1.49146997
137Limited hip movement (HP:0008800)1.46938326
138Pelvic girdle muscle weakness (HP:0003749)1.43077364
139Type 2 muscle fiber atrophy (HP:0003554)1.43017420
140Abnormality of the musculature of the pelvis (HP:0001469)1.42665141
141Abnormality of the hip-girdle musculature (HP:0001445)1.42665141
142Muscle fiber atrophy (HP:0100295)1.42382283
143Shoulder girdle muscle weakness (HP:0003547)1.39272710
144Nonprogressive disorder (HP:0003680)1.39122411

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN5.56349357
2OBSCN5.06562092
3PHKG14.27997613
4PHKG24.27997613
5PDK33.00469929
6PDK43.00469929
7BCKDK2.96000748
8EEF2K2.72408172
9LMTK22.59238692
10TRIB32.53493742
11DMPK2.39968959
12PINK12.36379733
13PKN22.17388835
14MYLK2.12481077
15WNK42.11552356
16MUSK1.99788166
17STK391.88497488
18PIK3CA1.82714896
19PDK21.74965013
20PRPF4B1.69208850
21MAP3K71.58471486
22NEK11.53901965
23TIE11.50635651
24EPHB11.48462360
25PIK3CG1.38336669
26INSRR1.36567277
27PAK31.36228272
28SMG11.29324062
29PRKD11.28413689
30PKN11.25984929
31MAPK121.23646572
32ICK1.14205606
33CAMK2D1.13036973
34NME11.12668249
35MAP3K131.09064034
36CDK121.08401992
37WNK11.07549297
38MAP2K31.03159671
39PRKAA21.00816292
40OXSR11.00295397
41SIK11.00162469
42PRKAA10.94921594
43STK240.86627340
44MOS0.84564243
45STK38L0.84436086
46ROCK10.82783617
47GRK70.78405726
48RIPK10.76694165
49CCNB10.75440558
50ILK0.73479746
51RPS6KB20.73110119
52TRPM70.71799674
53LATS10.68753762
54ROCK20.67500204
55MAP3K100.66814633
56TAOK20.61955449
57PAK60.61025723
58PRKD30.60357447
59CAMK2G0.60280025
60STK40.59796692
61FGFR40.59308034
62MAP3K30.59274554
63PTK60.58820709
64MAPK40.57053757
65PDPK10.56945534
66STK380.56650834
67KSR20.55925046
68CAMK1G0.55740980
69CDC42BPA0.54807064
70TBK10.54232874
71MAP2K40.54039086
72ERN10.53353092
73CAMK2A0.52087367
74PRKACB0.51739155
75MAP2K10.50729575
76PDGFRA0.49478955
77CAMK40.46365312
78MAP3K50.46043661
79AKT20.45250221
80PRKCH0.44841576
81PTK2B0.44585680
82MAPKAPK30.42472856
83PRKACA0.42225462
84MAPK110.42205530
85SGK30.41956739
86NEK90.41542504
87LATS20.40721957
88MARK20.40669495
89TNK20.40551413
90MET0.39982598
91PRKACG0.39846469
92DAPK30.39818390
93SGK2230.38784583
94SGK4940.38784583
95MAP2K60.38622996
96PDK10.38135702
97ARAF0.38002909
98IRAK30.37613042
99FGFR20.37151445
100LIMK10.36709263
101RPS6KA60.36512934
102RPS6KA20.36111432
103CDK40.35604457
104FLT30.33837769
105WNK30.33037238
106MAP3K110.32652733
107FER0.32523536
108MTOR0.31784643
109CAMK1D0.31485211
110RET0.31363886
111MST1R0.30891888
112PRKCE0.30355736
113CAMK10.30034560
114MAP4K10.29743115
115RPS6KA10.29263357
116DYRK1B0.28980891
117TGFBR20.28450837
118MAP3K10.28266881
119SGK10.28244901
120RPS6KL10.27579951
121RPS6KC10.27579951
122MAPK70.27360945
123MAPK100.26416528
124PRKG10.26030777
125GSK3A0.24217023
126PRKD20.24052900
127RPS6KA30.23888705
128MAP3K60.23525775
129LRRK20.23276691
130TAOK10.22367500
131MAP2K20.22238414
132RPS6KB10.21575597
133BRAF0.20889682
134CAMK2B0.19849133
135EPHA20.17833707
136MARK10.16951864
137MAPK80.14905772
138MAP3K140.12829142
139RAF10.12262129
140MAPK30.12048446
141GSK3B0.11474442
142CDK90.11205046

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.07481297
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.61348209
3Propanoate metabolism_Homo sapiens_hsa006403.53936389
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.37296198
5Fatty acid degradation_Homo sapiens_hsa000713.10671586
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.01409464
7Cardiac muscle contraction_Homo sapiens_hsa042602.90729607
8Fatty acid metabolism_Homo sapiens_hsa012122.49765099
9Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.41168329
10Dilated cardiomyopathy_Homo sapiens_hsa054142.41076455
11Butanoate metabolism_Homo sapiens_hsa006502.39988942
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.39945557
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.30535885
14Carbon metabolism_Homo sapiens_hsa012002.21883015
15Fatty acid elongation_Homo sapiens_hsa000622.16998838
16Pyruvate metabolism_Homo sapiens_hsa006202.15158405
17Oxidative phosphorylation_Homo sapiens_hsa001902.04261243
18Parkinsons disease_Homo sapiens_hsa050122.00629385
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.75198357
20Tryptophan metabolism_Homo sapiens_hsa003801.75133918
21Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.73752883
22Arginine biosynthesis_Homo sapiens_hsa002201.64077477
23Alzheimers disease_Homo sapiens_hsa050101.54646277
24PPAR signaling pathway_Homo sapiens_hsa033201.53633152
25Nitrogen metabolism_Homo sapiens_hsa009101.49391344
26Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.48845473
27Peroxisome_Homo sapiens_hsa041461.45902922
28beta-Alanine metabolism_Homo sapiens_hsa004101.32708770
29Starch and sucrose metabolism_Homo sapiens_hsa005001.29838735
30Primary bile acid biosynthesis_Homo sapiens_hsa001201.26289193
31Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.23651794
32Biosynthesis of amino acids_Homo sapiens_hsa012301.22644520
33Arginine and proline metabolism_Homo sapiens_hsa003301.12130320
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.09628333
35Huntingtons disease_Homo sapiens_hsa050161.07995354
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.05995151
37Lysine degradation_Homo sapiens_hsa003101.05822222
38GnRH signaling pathway_Homo sapiens_hsa049121.01460050
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.98599540
40Insulin resistance_Homo sapiens_hsa049310.95054983
41Bile secretion_Homo sapiens_hsa049760.93074343
42Sulfur metabolism_Homo sapiens_hsa009200.93065301
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.91276524
44Glucagon signaling pathway_Homo sapiens_hsa049220.88512036
45Adipocytokine signaling pathway_Homo sapiens_hsa049200.86603207
46Phenylalanine metabolism_Homo sapiens_hsa003600.86257200
47Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.84337501
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83249495
49Viral myocarditis_Homo sapiens_hsa054160.82896448
50Tyrosine metabolism_Homo sapiens_hsa003500.80126609
51VEGF signaling pathway_Homo sapiens_hsa043700.79696873
52Fatty acid biosynthesis_Homo sapiens_hsa000610.79661276
53Non-small cell lung cancer_Homo sapiens_hsa052230.76943207
54mTOR signaling pathway_Homo sapiens_hsa041500.73270199
55Sulfur relay system_Homo sapiens_hsa041220.70182323
56AMPK signaling pathway_Homo sapiens_hsa041520.67786498
57Insulin signaling pathway_Homo sapiens_hsa049100.67598425
58B cell receptor signaling pathway_Homo sapiens_hsa046620.66832574
59Bladder cancer_Homo sapiens_hsa052190.66708305
60FoxO signaling pathway_Homo sapiens_hsa040680.65857422
61Long-term potentiation_Homo sapiens_hsa047200.65315127
62Acute myeloid leukemia_Homo sapiens_hsa052210.64505684
63Glioma_Homo sapiens_hsa052140.63622856
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63488776
65cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61511062
66Histidine metabolism_Homo sapiens_hsa003400.60831623
67Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.60382846
68Aldosterone synthesis and secretion_Homo sapiens_hsa049250.58746858
69Cysteine and methionine metabolism_Homo sapiens_hsa002700.57965494
70Chronic myeloid leukemia_Homo sapiens_hsa052200.57930486
71Tight junction_Homo sapiens_hsa045300.57644410
72ABC transporters_Homo sapiens_hsa020100.57404504
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.55975167
74Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54825811
75Fat digestion and absorption_Homo sapiens_hsa049750.54093418
76Notch signaling pathway_Homo sapiens_hsa043300.53670511
77MAPK signaling pathway_Homo sapiens_hsa040100.53017127
78Endometrial cancer_Homo sapiens_hsa052130.52565197
79Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51394290
80Thyroid cancer_Homo sapiens_hsa052160.50173611
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49502618
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47344201
83Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46700211
84Glycerolipid metabolism_Homo sapiens_hsa005610.45177820
85Selenocompound metabolism_Homo sapiens_hsa004500.43313503
86Systemic lupus erythematosus_Homo sapiens_hsa053220.43049803
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42851830
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.41005349
89Pancreatic cancer_Homo sapiens_hsa052120.40916480
90Gastric acid secretion_Homo sapiens_hsa049710.40109596
91AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.40059531
92Metabolic pathways_Homo sapiens_hsa011000.40050730
93Chemical carcinogenesis_Homo sapiens_hsa052040.39226435
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39047674
95Retinol metabolism_Homo sapiens_hsa008300.37984702
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37401403
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37339367
98Calcium signaling pathway_Homo sapiens_hsa040200.36760278
99Small cell lung cancer_Homo sapiens_hsa052220.35511994
100Complement and coagulation cascades_Homo sapiens_hsa046100.35458943
101Linoleic acid metabolism_Homo sapiens_hsa005910.35009384
102Fructose and mannose metabolism_Homo sapiens_hsa000510.34787414
103Oxytocin signaling pathway_Homo sapiens_hsa049210.33672729
104Type II diabetes mellitus_Homo sapiens_hsa049300.33569156
105Focal adhesion_Homo sapiens_hsa045100.33461152
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.31648974
107Melanogenesis_Homo sapiens_hsa049160.31327909
108Cyanoamino acid metabolism_Homo sapiens_hsa004600.30686269
109Adherens junction_Homo sapiens_hsa045200.30629362
110Phosphatidylinositol signaling system_Homo sapiens_hsa040700.30260480
111Circadian rhythm_Homo sapiens_hsa047100.29292795
112Leukocyte transendothelial migration_Homo sapiens_hsa046700.28106232
113Platelet activation_Homo sapiens_hsa046110.27921854
114Glutathione metabolism_Homo sapiens_hsa004800.27287144
115Proteoglycans in cancer_Homo sapiens_hsa052050.26851655
116Viral carcinogenesis_Homo sapiens_hsa052030.26817941
117HTLV-I infection_Homo sapiens_hsa051660.26608488
118Galactose metabolism_Homo sapiens_hsa000520.26554669
119Estrogen signaling pathway_Homo sapiens_hsa049150.26306487
120Alcoholism_Homo sapiens_hsa050340.25290121
121Prostate cancer_Homo sapiens_hsa052150.25018628
122Renin secretion_Homo sapiens_hsa049240.24318282
123ErbB signaling pathway_Homo sapiens_hsa040120.23910586
124Longevity regulating pathway - mammal_Homo sapiens_hsa042110.22803759
125Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.22413099
126Amoebiasis_Homo sapiens_hsa051460.22175837
127Inositol phosphate metabolism_Homo sapiens_hsa005620.21784276
128Insulin secretion_Homo sapiens_hsa049110.21639613
129Cholinergic synapse_Homo sapiens_hsa047250.21453726
130Pentose phosphate pathway_Homo sapiens_hsa000300.21012716
131ECM-receptor interaction_Homo sapiens_hsa045120.20751090
132Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.19417876
133Central carbon metabolism in cancer_Homo sapiens_hsa052300.19416195
134Renal cell carcinoma_Homo sapiens_hsa052110.19346175
135Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.18424981
136Ovarian steroidogenesis_Homo sapiens_hsa049130.17853486
137HIF-1 signaling pathway_Homo sapiens_hsa040660.17090094
138Caffeine metabolism_Homo sapiens_hsa002320.16363196
139cAMP signaling pathway_Homo sapiens_hsa040240.15786148
140Thyroid hormone signaling pathway_Homo sapiens_hsa049190.14962434
141Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.14674324

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