PROC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.61089406
2L-phenylalanine catabolic process (GO:0006559)7.61089406
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.29312546
4L-phenylalanine metabolic process (GO:0006558)7.29312546
5aromatic amino acid family catabolic process (GO:0009074)6.85556878
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.33365346
7epoxygenase P450 pathway (GO:0019373)6.30637835
8regulation of plasminogen activation (GO:0010755)6.23353758
9indole-containing compound catabolic process (GO:0042436)6.20181351
10indolalkylamine catabolic process (GO:0046218)6.20181351
11tryptophan catabolic process (GO:0006569)6.20181351
12kynurenine metabolic process (GO:0070189)6.04736624
13glyoxylate metabolic process (GO:0046487)5.96613803
14bile acid biosynthetic process (GO:0006699)5.93600626
15tryptophan metabolic process (GO:0006568)5.84122475
16omega-hydroxylase P450 pathway (GO:0097267)5.77548180
17negative regulation of fibrinolysis (GO:0051918)5.63570806
18urea metabolic process (GO:0019627)5.61552596
19urea cycle (GO:0000050)5.61552596
20high-density lipoprotein particle remodeling (GO:0034375)5.58308415
21alpha-linolenic acid metabolic process (GO:0036109)5.52972832
22cysteine metabolic process (GO:0006534)5.47307777
23regulation of fibrinolysis (GO:0051917)5.43489603
24sulfur amino acid catabolic process (GO:0000098)5.38002443
25regulation of protein activation cascade (GO:2000257)5.29413666
26complement activation, alternative pathway (GO:0006957)5.28670652
27serine family amino acid catabolic process (GO:0009071)5.18937516
28nitrogen cycle metabolic process (GO:0071941)5.16964979
29intestinal cholesterol absorption (GO:0030299)5.16614413
30bile acid metabolic process (GO:0008206)5.05602199
31aromatic amino acid family metabolic process (GO:0009072)4.98774182
32fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.95557885
33regulation of complement activation (GO:0030449)4.93917952
34* peptidyl-glutamic acid carboxylation (GO:0017187)4.92768537
35* protein carboxylation (GO:0018214)4.92768537
36reverse cholesterol transport (GO:0043691)4.90659150
37regulation of cholesterol esterification (GO:0010872)4.86935596
38regulation of triglyceride catabolic process (GO:0010896)4.83111181
39homocysteine metabolic process (GO:0050667)4.80359752
40tyrosine metabolic process (GO:0006570)4.79576752
41protein-lipid complex remodeling (GO:0034368)4.77827899
42macromolecular complex remodeling (GO:0034367)4.77827899
43plasma lipoprotein particle remodeling (GO:0034369)4.77827899
44lysine catabolic process (GO:0006554)4.76519327
45lysine metabolic process (GO:0006553)4.76519327
46acute-phase response (GO:0006953)4.71634770
47negative regulation of protein activation cascade (GO:2000258)4.68654396
48alpha-amino acid catabolic process (GO:1901606)4.67571210
49amino-acid betaine metabolic process (GO:0006577)4.65446056
50triglyceride homeostasis (GO:0070328)4.62163952
51acylglycerol homeostasis (GO:0055090)4.62163952
52regulation of apoptotic cell clearance (GO:2000425)4.61628394
53positive regulation of blood coagulation (GO:0030194)4.61251468
54positive regulation of hemostasis (GO:1900048)4.61251468
55* negative regulation of blood coagulation (GO:0030195)4.57864469
56* negative regulation of hemostasis (GO:1900047)4.57864469
57phospholipid efflux (GO:0033700)4.57212448
58negative regulation of sterol transport (GO:0032372)4.56712610
59negative regulation of cholesterol transport (GO:0032375)4.56712610
60regulation of humoral immune response (GO:0002920)4.56566672
61cellular ketone body metabolic process (GO:0046950)4.54878401
62ethanol metabolic process (GO:0006067)4.48554332
63drug metabolic process (GO:0017144)4.47640269
64protein-lipid complex subunit organization (GO:0071825)4.46989079
65glycine metabolic process (GO:0006544)4.41278138
66plasma lipoprotein particle clearance (GO:0034381)4.39706354
67indolalkylamine metabolic process (GO:0006586)4.39577102
68coenzyme catabolic process (GO:0009109)4.37245621
69bile acid and bile salt transport (GO:0015721)4.33135689
70cellular amino acid catabolic process (GO:0009063)4.31690446
71glutamate metabolic process (GO:0006536)4.30650604
72imidazole-containing compound metabolic process (GO:0052803)4.30172145
73amine catabolic process (GO:0009310)4.29433668
74cellular biogenic amine catabolic process (GO:0042402)4.29433668
75oxidative demethylation (GO:0070989)4.28189183
76serine family amino acid metabolic process (GO:0009069)4.26072104
77phenylpropanoid metabolic process (GO:0009698)4.25110255
78cellular glucuronidation (GO:0052695)4.22514780
79positive regulation of coagulation (GO:0050820)4.22235419
80cholesterol efflux (GO:0033344)4.21097180
81* negative regulation of coagulation (GO:0050819)4.16608619
82cellular modified amino acid catabolic process (GO:0042219)4.15501699
83benzene-containing compound metabolic process (GO:0042537)4.13683233
84positive regulation of fatty acid biosynthetic process (GO:0045723)4.12574381
85serine family amino acid biosynthetic process (GO:0009070)4.08376448
86* negative regulation of wound healing (GO:0061045)4.07907160
87ethanol oxidation (GO:0006069)4.06049020
88aldehyde catabolic process (GO:0046185)4.05050047
89drug catabolic process (GO:0042737)4.04780371
90dicarboxylic acid biosynthetic process (GO:0043650)4.04518869
91fibrinolysis (GO:0042730)4.02612523
92arginine metabolic process (GO:0006525)4.02586199
93plasma lipoprotein particle assembly (GO:0034377)4.00057795
94low-density lipoprotein particle remodeling (GO:0034374)3.95132143
95proline metabolic process (GO:0006560)3.93938308
96ketone body metabolic process (GO:1902224)3.93779530
97negative regulation of complement activation (GO:0045916)3.90247261
98blood coagulation, intrinsic pathway (GO:0007597)3.84989956
99positive regulation of lipoprotein lipase activity (GO:0051006)3.82175103
100positive regulation of triglyceride lipase activity (GO:0061365)3.82175103
101positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.81711804
102cofactor catabolic process (GO:0051187)3.78088550
103carboxylic acid catabolic process (GO:0046395)3.77738991
104organic acid catabolic process (GO:0016054)3.77738991
105uronic acid metabolic process (GO:0006063)3.76961722
106glucuronate metabolic process (GO:0019585)3.76961722
107phospholipid homeostasis (GO:0055091)3.74515511
108short-chain fatty acid metabolic process (GO:0046459)3.74343514
109cholesterol homeostasis (GO:0042632)3.74322299
110negative regulation of lipase activity (GO:0060192)3.72026765
111positive regulation of lipid catabolic process (GO:0050996)3.71813828
112complement activation, classical pathway (GO:0006958)3.71761437
113regulation of bile acid biosynthetic process (GO:0070857)3.70144509
114acetyl-CoA metabolic process (GO:0006084)3.69789655
115sterol homeostasis (GO:0055092)3.68646928
116protein activation cascade (GO:0072376)3.68064239
117complement activation (GO:0006956)3.67666286
118very-low-density lipoprotein particle assembly (GO:0034379)3.66118322
119lipoprotein metabolic process (GO:0042157)3.65938886
120regulation of cholesterol homeostasis (GO:2000188)3.65675890
121cytolysis (GO:0019835)3.63347693
122plasma lipoprotein particle organization (GO:0071827)3.62769282
123regulation of lipoprotein particle clearance (GO:0010984)3.62241591
124acute inflammatory response (GO:0002526)3.59436619
125urate metabolic process (GO:0046415)3.58812826
126protein-lipid complex assembly (GO:0065005)3.58789345
127exogenous drug catabolic process (GO:0042738)3.57073327
128sterol transport (GO:0015918)3.47382343
129cholesterol transport (GO:0030301)3.47382343
130opsonization (GO:0008228)3.34800831
131disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.33872991
132killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.33872991

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.42772300
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.22883390
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.98158128
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.50995437
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.28992101
6* CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.01615495
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.87578660
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.02520696
9* CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.90068303
10TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.08489431
11HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.05316452
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.00619894
13* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.9524388
14* FOXA2_19822575_ChIP-Seq_HepG2_Human1.60436326
15CLOCK_20551151_ChIP-Seq_293T_Human1.56189655
16CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.56029240
17HTT_18923047_ChIP-ChIP_STHdh_Human1.51807946
18GATA1_22025678_ChIP-Seq_K562_Human1.44068873
19* HNF4A_19822575_ChIP-Seq_HepG2_Human1.42227932
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.29131615
21RXRA_24833708_ChIP-Seq_LIVER_Mouse1.21149862
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.19966652
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.19119732
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.12732018
25TRIM28_21343339_ChIP-Seq_HEK293_Human1.09930093
26ESR1_15608294_ChIP-ChIP_MCF-7_Human1.05869381
27ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05516584
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.02117691
29PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96819557
30TP63_17297297_ChIP-ChIP_HaCaT_Human0.94532360
31SOX2_27498859_Chip-Seq_STOMACH_Mouse0.94496224
32TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.91987351
33RARG_19884340_ChIP-ChIP_MEFs_Mouse0.88230353
34TCF4_18268006_ChIP-ChIP_LS174T_Human0.87122946
35PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.86588599
36PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.85938058
37ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.85059863
38IRF8_22096565_ChIP-ChIP_GC-B_Human0.83693134
39AUTS2_25519132_ChIP-Seq_293T-REX_Human0.83447569
40GATA4_25053715_ChIP-Seq_YYC3_Human0.82635257
41ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.82431979
42DNAJC2_21179169_ChIP-ChIP_NT2_Human0.82302179
43POU5F1_16518401_ChIP-PET_MESCs_Mouse0.79135394
44SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.78056004
45KAP1_22055183_ChIP-Seq_ESCs_Mouse0.77361622
46RAC3_21632823_ChIP-Seq_H3396_Human0.75587492
47BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.74879204
48RARA_24833708_ChIP-Seq_LIVER_Mouse0.74580296
49ZNF263_19887448_ChIP-Seq_K562_Human0.73459396
50SOX2_21211035_ChIP-Seq_LN229_Human0.72767010
51* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.71385087
52CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.70721376
53Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.70513746
54* SMC4_20622854_ChIP-Seq_HELA_Human0.69954398
55ESR2_21235772_ChIP-Seq_MCF-7_Human0.68858527
56CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.68641962
57NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.68180195
58AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.67686226
59SALL4_18804426_ChIP-ChIP_XEN_Mouse0.67548209
60RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.65572450
61SOX2_20726797_ChIP-Seq_SW620_Human0.65277736
62NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.64191413
63NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.64103536
64RARB_24833708_ChIP-Seq_LIVER_Mouse0.63928028
65NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.62843776
66NRF2_20460467_ChIP-Seq_MEFs_Mouse0.62843776
67BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.62576493
68* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.61426478
69NFIB_24661679_ChIP-Seq_LUNG_Mouse0.61158007
70FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.60993600
71JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.60349810
72CSB_26484114_Chip-Seq_FIBROBLAST_Human0.59928833
73CTCF_27219007_Chip-Seq_Bcells_Human0.58478628
74CEBPB_22108803_ChIP-Seq_LS180_Human0.58421943
75STAT3_1855785_ChIP-Seq_MESCs_Mouse0.56308101
76EGR1_19032775_ChIP-ChIP_M12_Human0.56183640
77* E2F1_20622854_ChIP-Seq_HELA_Human0.56009886
78* LXR_22292898_ChIP-Seq_THP-1_Human0.54957081
79* GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.54472718
80AR_20517297_ChIP-Seq_VCAP_Human0.53512360
81MYC_19915707_ChIP-ChIP_AK7_Human0.53511707
82SOX11_22085726_ChIP-Seq_ESNs_Mouse0.53331134
83FOXA1_25552417_ChIP-Seq_VCAP_Human0.52910954
84SPI1_20517297_ChIP-Seq_HL60_Human0.52860430
85* ELF1_20517297_ChIP-Seq_JURKAT_Human0.52690898
86PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.52540723
87BCOR_27268052_Chip-Seq_Bcells_Human0.52452343
88NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.52433790
89FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.52411208
90SRY_22984422_ChIP-ChIP_TESTIS_Rat0.51930893
91ESR1_21235772_ChIP-Seq_MCF-7_Human0.51554379
92EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.50753125
93* P68_20966046_ChIP-Seq_HELA_Human0.50074560
94FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.49883646
95ESET_19884257_ChIP-Seq_ESCs_Mouse0.49508459
96HIF1A_21447827_ChIP-Seq_MCF-7_Human0.48383193
97CBP_21632823_ChIP-Seq_H3396_Human0.48146453
98SA1_27219007_Chip-Seq_Bcells_Human0.47585205
99GATA3_21867929_ChIP-Seq_CD8_Mouse0.47533091
100STAT1_17558387_ChIP-Seq_HELA_Human0.47369642
101GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.47314892
102POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.46978176
103CDX2_20551321_ChIP-Seq_CACO-2_Human0.46852345
104FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.46669345
105E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.46343737
106SOX2_22085726_ChIP-Seq_NPCs_Mouse0.46037653
107PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.45394396
108* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.45321884
109PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.44406549
110GATA1_19941827_ChIP-Seq_MEL_Mouse0.44376806
111PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.44324915
112GATA1_19941826_ChIP-Seq_K562_Human0.44245922
113* P53_21459846_ChIP-Seq_SAOS-2_Human0.44010710
114FOXO3_23340844_ChIP-Seq_DLD1_Human0.43252649
115SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.42948472
116GATA6_25053715_ChIP-Seq_YYC3_Human0.41545933
117FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.41370469
118* TAF2_19829295_ChIP-Seq_ESCs_Human0.41261858
119GATA2_19941826_ChIP-Seq_K562_Human0.40999101
120ERG_21242973_ChIP-ChIP_JURKAT_Human0.40622782
121PPAR_26484153_Chip-Seq_NCI-H1993_Human0.39776184
122STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.39189609
123TAF15_26573619_Chip-Seq_HEK293_Human0.38905567
124CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.38465345
125ESR1_20079471_ChIP-ChIP_T-47D_Human0.37330531
126BCAT_22108803_ChIP-Seq_LS180_Human0.36520484
127CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.36092039
128* MYC_27129775_Chip-Seq_CORNEA_Mouse0.36025657
129LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.35981892
130SPI1_26923725_Chip-Seq_HPCs_Mouse0.35748986
131ERG_20517297_ChIP-Seq_VCAP_Human0.34683371
132SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.34559237
133FOXH1_21741376_ChIP-Seq_EPCs_Human0.34534239
134NCOR_22424771_ChIP-Seq_293T_Human0.34328067
135SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.34269212

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.30301761
2MP0005360_urolithiasis7.63668786
3MP0005085_abnormal_gallbladder_physiolo6.38349137
4MP0005365_abnormal_bile_salt6.12054630
5MP0008875_abnormal_xenobiotic_pharmacok5.09912436
6MP0003806_abnormal_nucleotide_metabolis4.22814982
7MP0003252_abnormal_bile_duct3.90673598
8MP0010329_abnormal_lipoprotein_level3.56689942
9MP0009840_abnormal_foam_cell3.27380056
10MP0005083_abnormal_biliary_tract3.02365024
11MP0003195_calcinosis2.92174849
12MP0005332_abnormal_amino_acid2.87267383
13MP0001666_abnormal_nutrient_absorption2.58574068
14MP0003191_abnormal_cellular_cholesterol2.38718512
15MP0004019_abnormal_vitamin_homeostasis2.26478573
16* MP0000609_abnormal_liver_physiology2.11680843
17MP0002118_abnormal_lipid_homeostasis2.09252364
18MP0002138_abnormal_hepatobiliary_system2.06893202
19MP0003868_abnormal_feces_composition1.88068012
20MP0003122_maternal_imprinting1.85588258
21MP0005319_abnormal_enzyme/_coenzyme1.84156440
22MP0001764_abnormal_homeostasis1.68584309
23MP0005584_abnormal_enzyme/coenzyme_acti1.59422133
24MP0009697_abnormal_copulation1.54087728
25MP0000566_synostosis1.49013554
26MP0005451_abnormal_body_composition1.45982384
27MP0003011_delayed_dark_adaptation1.37708808
28MP0002132_abnormal_respiratory_system1.37111327
29MP0009643_abnormal_urine_homeostasis1.33797314
30MP0003186_abnormal_redox_activity1.30407164
31MP0003656_abnormal_erythrocyte_physiolo1.27869597
32* MP0000598_abnormal_liver_morphology1.15362064
33MP0002089_abnormal_postnatal_growth/wei1.14321535
34MP0003705_abnormal_hypodermis_morpholog1.13420743
35MP0005647_abnormal_sex_gland1.12255919
36MP0000604_amyloidosis1.08365891
37MP0003172_abnormal_lysosome_physiology1.06221480
38MP0009764_decreased_sensitivity_to1.05465108
39MP0005636_abnormal_mineral_homeostasis1.01945856
40MP0009763_increased_sensitivity_to1.00044574
41MP0002254_reproductive_system_inflammat0.99430581
42MP0010368_abnormal_lymphatic_system0.95187016
43MP0003123_paternal_imprinting0.93881678
44* MP0001915_intracranial_hemorrhage0.92708948
45MP0008469_abnormal_protein_level0.89423558
46MP0009642_abnormal_blood_homeostasis0.88285098
47MP0006036_abnormal_mitochondrial_physio0.85392358
48MP0005408_hypopigmentation0.84891815
49MP0003879_abnormal_hair_cell0.82679444
50MP0005084_abnormal_gallbladder_morpholo0.82450212
51MP0002876_abnormal_thyroid_physiology0.80381747
52MP0005670_abnormal_white_adipose0.79897996
53MP0005376_homeostasis/metabolism_phenot0.79765223
54MP0002078_abnormal_glucose_homeostasis0.78120612
55MP0009765_abnormal_xenobiotic_induced0.77181427
56MP0005220_abnormal_exocrine_pancreas0.74358340
57MP0002971_abnormal_brown_adipose0.70561950
58MP0005535_abnormal_body_temperature0.68878465
59MP0002282_abnormal_trachea_morphology0.68554231
60MP0001756_abnormal_urination0.68082676
61MP0005334_abnormal_fat_pad0.67176094
62MP0001661_extended_life_span0.66979515
63MP0004130_abnormal_muscle_cell0.66082714
64MP0003690_abnormal_glial_cell0.65050292
65MP0009053_abnormal_anal_canal0.64151563
66MP0005266_abnormal_metabolism0.64130000
67MP0003329_amyloid_beta_deposits0.63822229
68MP0000639_abnormal_adrenal_gland0.58986630
69MP0006035_abnormal_mitochondrial_morpho0.57587767
70MP0002249_abnormal_larynx_morphology0.53782530
71MP0002136_abnormal_kidney_physiology0.53636192
72MP0005448_abnormal_energy_balance0.53062072
73MP0005464_abnormal_platelet_physiology0.51838379
74MP0005167_abnormal_blood-brain_barrier0.51642561
75MP0005395_other_phenotype0.50343232
76MP0005409_darkened_coat_color0.50091222
77MP0005164_abnormal_response_to0.49703410
78MP0002928_abnormal_bile_duct0.49335449
79MP0003638_abnormal_response/metabolism_0.47959629
80MP0002822_catalepsy0.46920254
81MP0003718_maternal_effect0.45657946
82MP0004272_abnormal_basement_membrane0.45575468
83MP0008874_decreased_physiological_sensi0.44406205
84MP0005187_abnormal_penis_morphology0.43761656
85MP0008873_increased_physiological_sensi0.43522628
86MP0003724_increased_susceptibility_to0.42080930
87MP0003953_abnormal_hormone_level0.41380477
88MP0002909_abnormal_adrenal_gland0.41348016
89MP0004782_abnormal_surfactant_physiolog0.41139146
90MP0003075_altered_response_to0.41052118
91MP0003878_abnormal_ear_physiology0.40547503
92MP0005377_hearing/vestibular/ear_phenot0.40547503
93MP0002837_dystrophic_cardiac_calcinosis0.40341671
94MP0003436_decreased_susceptibility_to0.39993058
95MP0005666_abnormal_adipose_tissue0.39335106
96MP0005023_abnormal_wound_healing0.39030168
97MP0005166_decreased_susceptibility_to0.38664588
98MP0008872_abnormal_physiological_respon0.37616647
99MP0009672_abnormal_birth_weight0.37422712
100MP0005257_abnormal_intraocular_pressure0.36583452
101MP0009780_abnormal_chondrocyte_physiolo0.36079287
102MP0005248_abnormal_Harderian_gland0.35583049
103MP0004381_abnormal_hair_follicle0.35105258
104MP0002796_impaired_skin_barrier0.34825536
105MP0000230_abnormal_systemic_arterial0.34142625
106MP0000920_abnormal_myelination0.33918023
107MP0002168_other_aberrant_phenotype0.33844395
108MP0003632_abnormal_nervous_system0.33833247
109MP0000579_abnormal_nail_morphology0.31991307
110MP0009115_abnormal_fat_cell0.31800163
111MP0006082_CNS_inflammation0.31303870
112MP0004883_abnormal_blood_vessel0.31182905
113MP0005058_abnormal_lysosome_morphology0.31039942
114MP0000249_abnormal_blood_vessel0.31023046
115MP0009384_cardiac_valve_regurgitation0.30416248
116MP0004043_abnormal_pH_regulation0.30290850
117MP0006292_abnormal_olfactory_placode0.29929598
118MP0001243_abnormal_dermal_layer0.29643922
119MP0002970_abnormal_white_adipose0.29449577
120MP0000858_altered_metastatic_potential0.29004818
121MP0001853_heart_inflammation0.27424408
122MP0000003_abnormal_adipose_tissue0.27254679
123MP0003183_abnormal_peptide_metabolism0.26884648
124MP0001765_abnormal_ion_homeostasis0.25905179
125MP0001881_abnormal_mammary_gland0.25890425
126* MP0001845_abnormal_inflammatory_respons0.25667149
127MP0003567_abnormal_fetal_cardiomyocyte0.25237619
128MP0002135_abnormal_kidney_morphology0.25194377
129MP0002092_abnormal_eye_morphology0.24889826
130MP0001324_abnormal_eye_pigmentation0.24855106
131MP0003115_abnormal_respiratory_system0.23782014
132MP0003633_abnormal_nervous_system0.23249630
133MP0003121_genomic_imprinting0.23215746

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.43246281
2Intrahepatic cholestasis (HP:0001406)7.23721372
3* Deep venous thrombosis (HP:0002625)6.78249337
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.59195837
5Prolonged partial thromboplastin time (HP:0003645)6.52258372
6Hypobetalipoproteinemia (HP:0003563)6.29615441
7Xanthomatosis (HP:0000991)6.27822731
8Hyperlipoproteinemia (HP:0010980)5.50396366
9Complement deficiency (HP:0004431)5.32288405
10Joint hemorrhage (HP:0005261)4.81873923
11Hypolipoproteinemia (HP:0010981)4.75944615
12Hyperammonemia (HP:0001987)4.64844723
13Hyperglycinemia (HP:0002154)4.47107797
14Abnormality of the common coagulation pathway (HP:0010990)4.44077397
15Epidermoid cyst (HP:0200040)4.39887521
16Ketosis (HP:0001946)4.37664692
17Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.33948363
18Abnormality of glutamine family amino acid metabolism (HP:0010902)4.28472127
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.28073301
20Abnormality of methionine metabolism (HP:0010901)4.23287715
21Hypoalphalipoproteinemia (HP:0003233)4.21259508
22Abnormality of aspartate family amino acid metabolism (HP:0010899)4.18903152
23Fat malabsorption (HP:0002630)4.07903698
24Hyperglycinuria (HP:0003108)4.07494628
25Abnormality of glycine metabolism (HP:0010895)4.03300333
26Abnormality of serine family amino acid metabolism (HP:0010894)4.03300333
27Hypoglycemic coma (HP:0001325)3.88492921
28Abnormality of complement system (HP:0005339)3.87767112
29Abnormality of pyrimidine metabolism (HP:0004353)3.82031673
30Abnormality of the intrinsic pathway (HP:0010989)3.76070335
31Conjugated hyperbilirubinemia (HP:0002908)3.63686359
32Hypercholesterolemia (HP:0003124)3.54754499
33Nephritis (HP:0000123)3.44647782
34Abnormality of fatty-acid metabolism (HP:0004359)3.43482848
35Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.37360614
36Hyperbilirubinemia (HP:0002904)3.34399115
37Delayed CNS myelination (HP:0002188)3.17901629
38Abnormality of nucleobase metabolism (HP:0010932)3.17071763
39Ketoacidosis (HP:0001993)3.14513399
40Abnormality of serum amino acid levels (HP:0003112)3.09582762
41Steatorrhea (HP:0002570)3.07587843
42Spontaneous abortion (HP:0005268)3.03414110
43Hepatocellular carcinoma (HP:0001402)3.02789432
44Hypochromic microcytic anemia (HP:0004840)2.97123353
45Myocardial infarction (HP:0001658)2.89691412
46Abnormality of purine metabolism (HP:0004352)2.84591809
47Metabolic acidosis (HP:0001942)2.84074002
48Gout (HP:0001997)2.77931393
49Systemic lupus erythematosus (HP:0002725)2.75124950
50Skin nodule (HP:0200036)2.71034027
51Vascular calcification (HP:0004934)2.66701378
52Abnormality of dicarboxylic acid metabolism (HP:0010995)2.66590546
53Dicarboxylic aciduria (HP:0003215)2.66590546
54Lethargy (HP:0001254)2.65867148
55Osteomalacia (HP:0002749)2.53795002
56Acanthocytosis (HP:0001927)2.50515050
57Spastic diplegia (HP:0001264)2.47680512
58Hypoglycemic seizures (HP:0002173)2.46729033
59Abnormal gallbladder morphology (HP:0012437)2.44684394
60Cerebral edema (HP:0002181)2.44224255
61Glomerulonephritis (HP:0000099)2.41342383
62Mitral stenosis (HP:0001718)2.40287730
63Irritability (HP:0000737)2.40041883
64Neonatal onset (HP:0003623)2.40011395
65Cholelithiasis (HP:0001081)2.39012406
66Cardiovascular calcification (HP:0011915)2.36323524
67Recurrent gram-negative bacterial infections (HP:0005420)2.34709959
68Cholecystitis (HP:0001082)2.34215024
69Abnormal gallbladder physiology (HP:0012438)2.34215024
70Malnutrition (HP:0004395)2.33973150
71Abnormality of the Achilles tendon (HP:0005109)2.33799665
72Amyloidosis (HP:0011034)2.31493809
73Arthropathy (HP:0003040)2.31168552
74Generalized aminoaciduria (HP:0002909)2.22404590
75Enlarged kidneys (HP:0000105)2.22204711
76Sensorimotor neuropathy (HP:0007141)2.20048210
77Gingival bleeding (HP:0000225)2.19267649
78Esophageal varix (HP:0002040)2.18472097
79* Hemorrhage of the eye (HP:0011885)2.18393684
80Pancreatitis (HP:0001733)2.18097009
81Late onset (HP:0003584)2.17571883
82Vomiting (HP:0002013)2.15229335
83Menorrhagia (HP:0000132)2.14361396
84Brushfield spots (HP:0001088)2.12018445
85Abnormality of carpal bone ossification (HP:0006257)2.11714354
86Abnormal tarsal ossification (HP:0008369)2.08973461
87Reduced antithrombin III activity (HP:0001976)2.04652962
88Opisthotonus (HP:0002179)2.03803600
89* Purpura (HP:0000979)2.03756254
90Rickets (HP:0002748)2.03752933
91Abnormality of the gallbladder (HP:0005264)2.01006910
92Poikilocytosis (HP:0004447)1.99984860
93Hyperinsulinemic hypoglycemia (HP:0000825)1.99422217
94Alkalosis (HP:0001948)1.99008862
95Bifid scrotum (HP:0000048)1.97275310
96Abnormality of proline metabolism (HP:0010907)1.95825427
97Hydroxyprolinuria (HP:0003080)1.95825427
98Increased serum pyruvate (HP:0003542)1.94429334
99Potter facies (HP:0002009)1.91501213
100Facial shape deformation (HP:0011334)1.91501213
101Proximal tubulopathy (HP:0000114)1.91494108
102Hypophosphatemic rickets (HP:0004912)1.91454051
103Abnormal enzyme/coenzyme activity (HP:0012379)1.88739750
104Abnormality of iron homeostasis (HP:0011031)1.88485269
105Abnormal cartilage morphology (HP:0002763)1.88383849
106Increased purine levels (HP:0004368)1.88045733
107Hyperuricemia (HP:0002149)1.88045733
108Abnormality of transition element cation homeostasis (HP:0011030)1.87629921
109Renal cortical cysts (HP:0000803)1.84778800
110Fair hair (HP:0002286)1.82921252
111Elevated hepatic transaminases (HP:0002910)1.82079732
112* Thrombophlebitis (HP:0004418)1.81032299
113Status epilepticus (HP:0002133)1.80939409
114Epistaxis (HP:0000421)1.80342451
115Glycosuria (HP:0003076)1.77837863
116* Pulmonary embolism (HP:0002204)1.74635265
117Increased serum ferritin (HP:0003281)1.72580924
118Hyperphosphaturia (HP:0003109)1.72493724
119Abnormality of glycolysis (HP:0004366)1.71137493
120Vaginal fistula (HP:0004320)1.68863113
121Elevated alkaline phosphatase (HP:0003155)1.64963579
122Joint swelling (HP:0001386)1.61666441
123Abnormality of urine glucose concentration (HP:0011016)1.60420043
124Abnormality of alkaline phosphatase activity (HP:0004379)1.59881649
125Retinal atrophy (HP:0001105)1.57469409
126Pancreatic islet-cell hyperplasia (HP:0004510)1.55227573
127Abnormal delivery (HP:0001787)1.52064205
128Flat acetabular roof (HP:0003180)1.51922158
129Abnormal hand bone ossification (HP:0010660)1.51756415
130Abnormal ossification of hand bones (HP:0005921)1.51121209
131Abnormality of the lumbar spine (HP:0100712)1.50432212

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.37140607
2FGFR44.66894931
3SIK14.45457930
4ERN14.39538508
5TAOK33.00003265
6INSRR2.93848166
7ERBB42.88961678
8MAP2K42.28746664
9PIK3CA2.24458005
10PKN22.16536774
11MST1R2.15116357
12CDK122.10266907
13MAPK111.92774748
14TYRO31.90711206
15FLT31.84726580
16PIK3CG1.79815558
17TRIB31.77587110
18TYK21.67298768
19PDGFRA1.65898068
20FGFR11.63973440
21LATS11.60443785
22ABL21.48965984
23PTK61.48722943
24DAPK21.48382962
25NTRK31.41246525
26NEK91.37258290
27FRK1.30321982
28KDR1.30252574
29FGFR21.27992548
30AKT31.26169125
31SIK21.24394807
32EIF2AK11.23852455
33JAK21.21790880
34PINK11.20158956
35MAP3K71.19267791
36GRK61.15424447
37PRKAA21.11346432
38WNK11.10087992
39MAP3K21.09120283
40STK38L1.09066865
41MAP2K31.07069696
42TBK11.02116358
43ERBB20.99875981
44DDR20.98335981
45MAP3K100.97965742
46MAPK150.96526397
47JAK10.96452990
48MAPK40.95572558
49MAP3K140.92577180
50PRKCZ0.92275429
51EEF2K0.91385171
52EPHB10.89125499
53MAP3K30.88741435
54STK160.87634482
55MET0.85861103
56MAP3K110.81481174
57TIE10.80308823
58MAPK120.79273488
59DYRK1B0.77774385
60CDK60.77735024
61SGK10.76832388
62PRKACG0.75769403
63SMG10.74822237
64EPHA30.72934812
65CDK70.72736300
66EPHA20.71766839
67GSK3A0.71025515
68CAMK2G0.69336242
69CSK0.68655993
70CSNK1E0.68204934
71SGK30.67475436
72PRKAA10.67473587
73MAPKAPK30.67265567
74MAP2K60.65801823
75FGR0.65683049
76TGFBR20.61318601
77PTK20.60938285
78IRAK30.60303172
79RPS6KB10.59989188
80CAMK1D0.59838093
81CDC42BPA0.58567858
82RIPK10.58334661
83PDPK10.53978643
84MAPK70.53741377
85CSNK1D0.53543769
86FGFR30.51945555
87PRKG10.51685190
88IKBKE0.50820907
89SGK20.50502021
90CSF1R0.50299097
91PRKCQ0.49611272
92MATK0.47120283
93CSNK1G10.47056490
94EPHA40.46321570
95SGK4940.44726007
96SGK2230.44726007
97SRC0.44417225
98TAOK20.44256265
99GRK10.43012761
100MAP3K50.41990079
101RPS6KA30.41503853
102IGF1R0.41345750
103PRKACA0.40500578
104CSNK2A20.40446158
105MAP2K10.40289077
106PRKCG0.40267466
107CDK40.39491078
108RET0.38314509
109ICK0.38022306
110PKN10.37179784
111MAP3K130.37167984
112BRSK10.35880487
113PDK30.35742100
114PDK40.35742100
115MTOR0.35349448
116CSNK2A10.35253445
117MAP3K60.35223557
118KSR20.33171228
119PDK10.33006881
120EGFR0.32386687
121CAMK40.31687542
122MARK20.31537708
123WNK30.31251119
124PBK0.31057552
125PRKCB0.30885426
126MAP3K10.29179549
127MAPK30.28377784
128BCR0.27384521
129CDK80.26377354
130PRKCA0.26123873
131CSNK1G20.25678796
132IRAK10.24857888
133IRAK20.23905742
134CSNK1G30.22920904
135LATS20.22456824
136MAP2K20.22392795
137STK380.22305912
138PAK30.22267573
139CAMK1G0.22107967
140ZAP700.21776396
141CDK90.21012890
142WNK40.19806095

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.48295581
2Nitrogen metabolism_Homo sapiens_hsa009103.52705655
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.36768150
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.35835515
5Arginine biosynthesis_Homo sapiens_hsa002203.05044481
6Tryptophan metabolism_Homo sapiens_hsa003802.69739801
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.68975107
8* Complement and coagulation cascades_Homo sapiens_hsa046102.68582560
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.67716179
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.56657225
11Fatty acid degradation_Homo sapiens_hsa000712.50781308
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.42296150
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.27188769
14Butanoate metabolism_Homo sapiens_hsa006502.22552979
15Peroxisome_Homo sapiens_hsa041462.11229381
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.09516999
17Propanoate metabolism_Homo sapiens_hsa006401.96400811
18Chemical carcinogenesis_Homo sapiens_hsa052041.91103255
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.89928698
20Histidine metabolism_Homo sapiens_hsa003401.89550193
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.88337500
22PPAR signaling pathway_Homo sapiens_hsa033201.86472108
23Fatty acid metabolism_Homo sapiens_hsa012121.81882557
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.73967255
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.73008101
26Staphylococcus aureus infection_Homo sapiens_hsa051501.72553826
27beta-Alanine metabolism_Homo sapiens_hsa004101.72277429
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.70599698
29Caffeine metabolism_Homo sapiens_hsa002321.68277373
30Retinol metabolism_Homo sapiens_hsa008301.67235251
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.64405511
32Selenocompound metabolism_Homo sapiens_hsa004501.58702071
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.57310287
34Phenylalanine metabolism_Homo sapiens_hsa003601.54949014
35Bile secretion_Homo sapiens_hsa049761.50042732
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.46636150
37Tyrosine metabolism_Homo sapiens_hsa003501.42186690
38Pyruvate metabolism_Homo sapiens_hsa006201.41081022
39Sulfur metabolism_Homo sapiens_hsa009201.37950434
40Fatty acid elongation_Homo sapiens_hsa000621.33315036
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.31883286
42Starch and sucrose metabolism_Homo sapiens_hsa005001.27525694
43Folate biosynthesis_Homo sapiens_hsa007901.22904640
44Biosynthesis of amino acids_Homo sapiens_hsa012301.20881596
45Steroid biosynthesis_Homo sapiens_hsa001001.19049905
46ABC transporters_Homo sapiens_hsa020101.17112056
47Fat digestion and absorption_Homo sapiens_hsa049751.15213965
48Carbon metabolism_Homo sapiens_hsa012001.15069492
49Cyanoamino acid metabolism_Homo sapiens_hsa004601.09767375
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.07993435
51Maturity onset diabetes of the young_Homo sapiens_hsa049501.02619221
52Arginine and proline metabolism_Homo sapiens_hsa003300.99304074
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.97882116
54Sulfur relay system_Homo sapiens_hsa041220.96030540
55Vitamin B6 metabolism_Homo sapiens_hsa007500.95679043
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91843474
57Vitamin digestion and absorption_Homo sapiens_hsa049770.91122410
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86230733
59Lysine degradation_Homo sapiens_hsa003100.82916795
60One carbon pool by folate_Homo sapiens_hsa006700.75404492
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71974668
62Other glycan degradation_Homo sapiens_hsa005110.71972665
63Glycerolipid metabolism_Homo sapiens_hsa005610.68239753
64Glutathione metabolism_Homo sapiens_hsa004800.68201609
65Pentose phosphate pathway_Homo sapiens_hsa000300.57917013
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53305547
67Fatty acid biosynthesis_Homo sapiens_hsa000610.49166939
68Metabolic pathways_Homo sapiens_hsa011000.46858504
69Pertussis_Homo sapiens_hsa051330.43716323
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37457860
71Prion diseases_Homo sapiens_hsa050200.35332166
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26158978
73Galactose metabolism_Homo sapiens_hsa000520.25937592
74Fructose and mannose metabolism_Homo sapiens_hsa000510.25872911
75Insulin resistance_Homo sapiens_hsa049310.22469789
76Linoleic acid metabolism_Homo sapiens_hsa005910.21588617
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.20918775
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.20488934
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.15095529
80Mineral absorption_Homo sapiens_hsa049780.09624628
81Glucagon signaling pathway_Homo sapiens_hsa049220.09562438
82N-Glycan biosynthesis_Homo sapiens_hsa005100.09489071
83Sphingolipid metabolism_Homo sapiens_hsa006000.02434038
84AMPK signaling pathway_Homo sapiens_hsa041520.01580452
85Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2437961
86Amoebiasis_Homo sapiens_hsa05146-0.2424741
87Bladder cancer_Homo sapiens_hsa05219-0.2390601
88Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2387926
89Serotonergic synapse_Homo sapiens_hsa04726-0.2038635
90Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1994261
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1899534
92Lysosome_Homo sapiens_hsa04142-0.1826795
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1785674
94Hepatitis C_Homo sapiens_hsa05160-0.1768460
95Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1751570
96ECM-receptor interaction_Homo sapiens_hsa04512-0.1708349
97Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1623533
98Renin-angiotensin system_Homo sapiens_hsa04614-0.1601970
99African trypanosomiasis_Homo sapiens_hsa05143-0.1497573
100Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1444449
101Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1417377
102Regulation of autophagy_Homo sapiens_hsa04140-0.1347679
103Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1266962
104Insulin signaling pathway_Homo sapiens_hsa04910-0.1099642
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0987097
106Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0764226
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0736814
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0341494

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