PROCA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1reproduction (GO:0000003)9.84627054
2binding of sperm to zona pellucida (GO:0007339)9.73148014
3cell-cell recognition (GO:0009988)9.71387852
4plasma membrane fusion (GO:0045026)9.67023503
5epithelial cilium movement (GO:0003351)9.52434879
6negative regulation of leukocyte chemotaxis (GO:0002689)9.49180707
7axonemal dynein complex assembly (GO:0070286)9.24270608
8cilium or flagellum-dependent cell motility (GO:0001539)9.19906478
9spermatid development (GO:0007286)9.03046101
10motile cilium assembly (GO:0044458)8.57823572
11cilium movement (GO:0003341)7.83962020
12regulation of cilium movement (GO:0003352)7.74401976
13single fertilization (GO:0007338)7.47961334
14sperm capacitation (GO:0048240)7.36761143
15male meiosis (GO:0007140)7.09606218
16epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.03161587
17synaptonemal complex organization (GO:0070193)6.76389682
18regulation of macrophage chemotaxis (GO:0010758)6.70374596
19response to misfolded protein (GO:0051788)6.69945668
20synaptonemal complex assembly (GO:0007130)6.61385948
21piRNA metabolic process (GO:0034587)6.36046775
22erythrocyte maturation (GO:0043249)6.23477032
23granulocyte differentiation (GO:0030851)6.18488218
24estrogen biosynthetic process (GO:0006703)6.08825442
25microtubule depolymerization (GO:0007019)6.02256344
26fertilization (GO:0009566)6.01860829
27organic cation transport (GO:0015695)5.98854431
28spermatogenesis (GO:0007283)5.93547871
29male gamete generation (GO:0048232)5.91866881
30spermatid nucleus differentiation (GO:0007289)5.66370938
31gamete generation (GO:0007276)5.47581527
32negative regulation of inclusion body assembly (GO:0090084)5.40131543
33rRNA methylation (GO:0031167)5.32755285
34calcium ion-dependent exocytosis (GO:0017156)4.99944172
35cellular process involved in reproduction in multicellular organism (GO:0022412)4.95788268
36sexual reproduction (GO:0019953)4.94672053
37germ cell development (GO:0007281)4.94628014
38response to pheromone (GO:0019236)4.93617647
39single strand break repair (GO:0000012)4.84046811
40regulation of inclusion body assembly (GO:0090083)4.82360710
41phosphatidylethanolamine biosynthetic process (GO:0006646)4.81505815
42cell recognition (GO:0008037)4.67403865
43chromosome organization involved in meiosis (GO:0070192)4.60889757
44microtubule severing (GO:0051013)4.58138844
45misfolded or incompletely synthesized protein catabolic process (GO:0006515)4.57232363
46ventricular system development (GO:0021591)4.55255290
47positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)4.54664383
48protein K11-linked deubiquitination (GO:0035871)4.53319466
49rRNA modification (GO:0000154)4.52074785
50histone H2B ubiquitination (GO:0033523)4.49246940
51macrophage differentiation (GO:0030225)4.40825206
52phosphatidylethanolamine metabolic process (GO:0046337)4.36930641
53chromatin silencing (GO:0006342)4.35658313
54male meiosis I (GO:0007141)4.33686152
55multicellular organismal reproductive process (GO:0048609)4.32308421
56glycerol ether metabolic process (GO:0006662)4.20274114
57regulation of microtubule-based movement (GO:0060632)4.20223817
58DNA methylation involved in gamete generation (GO:0043046)4.17779977
59monoubiquitinated protein deubiquitination (GO:0035520)4.10800395
60mitotic G1 DNA damage checkpoint (GO:0031571)4.05668111
61cell fate commitment involved in formation of primary germ layer (GO:0060795)3.99999171
62ether metabolic process (GO:0018904)3.94284156
63meiotic nuclear division (GO:0007126)3.90110001
64negative regulation of NF-kappaB import into nucleus (GO:0042347)3.89069085
65G1 DNA damage checkpoint (GO:0044783)3.83928667
66negative regulation of histone methylation (GO:0031061)3.82979740
67phosphatidylglycerol biosynthetic process (GO:0006655)3.81704724
68regulation of autophagic vacuole assembly (GO:2000785)3.79150442
69negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.71442341
70amino-acid betaine transport (GO:0015838)3.71379474
71carnitine transport (GO:0015879)3.71379474
72carnitine transmembrane transport (GO:1902603)3.69951251
73chromosome condensation (GO:0030261)3.69668888
74response to nitrosative stress (GO:0051409)3.65727036
75cytoplasmic sequestering of transcription factor (GO:0042994)3.62344278
76seminiferous tubule development (GO:0072520)3.61890113
77DNA packaging (GO:0006323)3.60633501
78mitotic G1/S transition checkpoint (GO:0044819)3.60275847
79genitalia morphogenesis (GO:0035112)3.56100014
80alditol metabolic process (GO:0019400)3.54281468
81negative regulation of gene expression, epigenetic (GO:0045814)3.51085768
82CDP-diacylglycerol biosynthetic process (GO:0016024)3.48462421
83RNA destabilization (GO:0050779)3.44169575
84cranial nerve morphogenesis (GO:0021602)3.43803917
85cerebellar granule cell differentiation (GO:0021707)3.41578443
86response to acidic pH (GO:0010447)3.40996540
87multicellular organismal development (GO:0007275)3.40557386
88protein polyglutamylation (GO:0018095)3.40109268
89meiosis I (GO:0007127)3.35654122
90cell migration in hindbrain (GO:0021535)3.31473712
91left/right pattern formation (GO:0060972)3.24962421
92glycerol metabolic process (GO:0006071)3.24773867
93cellular response to pH (GO:0071467)3.20189097
94cardiolipin metabolic process (GO:0032048)3.19546807
95protein destabilization (GO:0031648)3.16051530
96centriole replication (GO:0007099)3.15436278
97cellular ketone body metabolic process (GO:0046950)3.15003672
98CDP-diacylglycerol metabolic process (GO:0046341)3.14384221
99microtubule polymerization or depolymerization (GO:0031109)3.12624736
100regulation of vacuole organization (GO:0044088)3.09670052
101negative regulation of leukocyte migration (GO:0002686)3.09222814
102negative regulation of fibroblast proliferation (GO:0048147)3.08585867
103regulation of Rab GTPase activity (GO:0032313)3.05188301
104positive regulation of Rab GTPase activity (GO:0032851)3.05188301
105chaperone-mediated protein complex assembly (GO:0051131)3.04588768
106positive regulation of mRNA 3-end processing (GO:0031442)3.04191237
107histone exchange (GO:0043486)3.02942825
108establishment of protein localization to Golgi (GO:0072600)2.99488722
109negative regulation of Rho protein signal transduction (GO:0035024)2.97735839
110regulation of ARF GTPase activity (GO:0032312)2.96471331
111protein targeting to Golgi (GO:0000042)2.96342090
112nonmotile primary cilium assembly (GO:0035058)2.95556357
113positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.94719672
114intraciliary transport (GO:0042073)2.92812636
115glycolytic process (GO:0006096)2.92295713
116protein-DNA complex disassembly (GO:0032986)2.88007412
117nucleosome disassembly (GO:0006337)2.88007412
118early endosome to late endosome transport (GO:0045022)2.87482421
119cilium organization (GO:0044782)2.86733733
120G-protein coupled receptor internalization (GO:0002031)2.86435553
121primary amino compound metabolic process (GO:1901160)2.83758941
122cilium assembly (GO:0042384)2.80694424
123lactate metabolic process (GO:0006089)2.77727557
124regulation of spindle checkpoint (GO:0090231)2.76682292
125cellular component assembly involved in morphogenesis (GO:0010927)2.75588194
126nucleus organization (GO:0006997)2.74640219
127meiotic cell cycle (GO:0051321)2.72928909
128cilium morphogenesis (GO:0060271)2.70021061
129polyol catabolic process (GO:0046174)2.67263470
130protein localization to cilium (GO:0061512)2.66832762
131regulation of cytokine production involved in inflammatory response (GO:1900015)2.65648157
132fructose metabolic process (GO:0006000)2.65466830
133centriole assembly (GO:0098534)2.65366092
134axoneme assembly (GO:0035082)2.65028956
135synapsis (GO:0007129)2.63341336
136quaternary ammonium group transport (GO:0015697)2.59012334
137meiotic cell cycle process (GO:1903046)2.54297574
138nucleoside diphosphate phosphorylation (GO:0006165)2.51323156
139positive regulation of macrophage activation (GO:0043032)2.48682579
140microtubule-based movement (GO:0007018)2.44467934
141protein refolding (GO:0042026)2.43283575
142sequestering of actin monomers (GO:0042989)2.40942398
143mitotic sister chromatid cohesion (GO:0007064)2.39004876
144regulation of sequestering of triglyceride (GO:0010889)2.37182906
145peptidyl-glutamic acid modification (GO:0018200)2.35478255
146sister chromatid cohesion (GO:0007062)2.22946956
147GTP biosynthetic process (GO:0006183)2.21768617
148negative regulation of skeletal muscle tissue development (GO:0048642)2.21264501
149calcium ion import (GO:0070509)2.20396683
150female gonad development (GO:0008585)2.19341394
151cell wall macromolecule catabolic process (GO:0016998)13.4119336
152cell wall macromolecule metabolic process (GO:0044036)13.4119336
153sperm motility (GO:0030317)12.8709138
154fusion of sperm to egg plasma membrane (GO:0007342)12.7567593
155acrosome assembly (GO:0001675)11.5927581
156multicellular organism reproduction (GO:0032504)11.2461419
157sperm-egg recognition (GO:0035036)10.8726074
158acrosome reaction (GO:0007340)10.6262305

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse7.23940088
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.80408802
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.11799457
4TP63_19390658_ChIP-ChIP_HaCaT_Human3.58055059
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.23826232
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.12215432
7E2F7_22180533_ChIP-Seq_HELA_Human2.99188816
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.92306674
9EZH2_22144423_ChIP-Seq_EOC_Human2.83683947
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.71389300
11PCGF2_27294783_Chip-Seq_ESCs_Mouse2.65610036
12CTCF_27219007_Chip-Seq_Bcells_Human2.55300011
13VDR_22108803_ChIP-Seq_LS180_Human2.48241787
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.27532793
15LXR_22292898_ChIP-Seq_THP-1_Human2.27239863
16DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.23685671
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.19924059
18P68_20966046_ChIP-Seq_HELA_Human2.18022217
19PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.13337314
20EBNA2_21746931_ChIP-Seq_IB4-LCL_Human2.07067647
21SUZ12_27294783_Chip-Seq_NPCs_Mouse2.02275515
22CBX2_27304074_Chip-Seq_ESCs_Mouse2.02256770
23MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human2.02102307
24YY1_22570637_ChIP-Seq_MALME-3M_Human2.01061034
25EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.99521999
26KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.98663520
27NFE2_27457419_Chip-Seq_LIVER_Mouse1.97626905
28KAP1_22055183_ChIP-Seq_ESCs_Mouse1.97561197
29ELF1_20517297_ChIP-Seq_JURKAT_Human1.96753249
30IRF1_19129219_ChIP-ChIP_H3396_Human1.95842741
31PCGF2_27294783_Chip-Seq_NPCs_Mouse1.91895487
32SMC4_20622854_ChIP-Seq_HELA_Human1.90579243
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.89473256
34ERA_21632823_ChIP-Seq_H3396_Human1.87255356
35BCL6_27268052_Chip-Seq_Bcells_Human1.86890239
36MYC_19829295_ChIP-Seq_ESCs_Human1.86033029
37RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.85751061
38MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.85671204
39CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.82691342
40GBX2_23144817_ChIP-Seq_PC3_Human1.81526083
41GATA1_26923725_Chip-Seq_HPCs_Mouse1.80888025
42RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.79538090
43TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.79216936
44BCOR_27268052_Chip-Seq_Bcells_Human1.77873399
45* SRY_22984422_ChIP-ChIP_TESTIS_Rat1.76522898
46ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.76423942
47EZH2_27304074_Chip-Seq_ESCs_Mouse1.75463676
48STAT1_17558387_ChIP-Seq_HELA_Human1.73118614
49TAL1_26923725_Chip-Seq_HPCs_Mouse1.72809674
50TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.72621046
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.71227084
52IKZF1_21737484_ChIP-ChIP_HCT116_Human1.70999522
53EZH2_27294783_Chip-Seq_ESCs_Mouse1.70526366
54NANOG_20526341_ChIP-Seq_ESCs_Human1.69080636
55E2F1_20622854_ChIP-Seq_HELA_Human1.68931255
56NANOG_18555785_Chip-Seq_ESCs_Mouse1.68035338
57ELK4_26923725_Chip-Seq_MESODERM_Mouse1.67320676
58ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.66886218
59DROSHA_22980978_ChIP-Seq_HELA_Human1.66561769
60MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.61291253
61SUZ12_27294783_Chip-Seq_ESCs_Mouse1.61112144
62SA1_27219007_Chip-Seq_ERYTHROID_Human1.60594599
63RBPJ_22232070_ChIP-Seq_NCS_Mouse1.59435935
64KDM2B_26808549_Chip-Seq_REH_Human1.59311828
65EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.58668740
66PHF8_20622854_ChIP-Seq_HELA_Human1.57937866
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.52936776
68VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.50526357
69SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.50498996
70CBP_20019798_ChIP-Seq_JUKART_Human1.50220591
71IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.50220591
72CMYC_18555785_Chip-Seq_ESCs_Mouse1.48949999
73P300_27268052_Chip-Seq_Bcells_Human1.48873091
74EZH2_27294783_Chip-Seq_NPCs_Mouse1.48429056
75P53_22387025_ChIP-Seq_ESCs_Mouse1.48246637
76OCT4_18555785_Chip-Seq_ESCs_Mouse1.46995705
77TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45080219
78TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44721470
79POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.44721470
80CTCF_20526341_ChIP-Seq_ESCs_Human1.44644998
81STAT3_18555785_Chip-Seq_ESCs_Mouse1.44181732
82TDRD3_21172665_ChIP-Seq_MCF-7_Human1.43719886
83CRX_20693478_ChIP-Seq_RETINA_Mouse1.43404239
84SUZ12_18555785_Chip-Seq_ESCs_Mouse1.41657959
85P300_18555785_Chip-Seq_ESCs_Mouse1.41596415
86ZNF274_21170338_ChIP-Seq_K562_Hela1.38399250
87CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.37603787
88CTCF_21964334_Chip-Seq_Bcells_Human1.37270206
89EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.36244241
90* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.35968000
91OCT4_20526341_ChIP-Seq_ESCs_Human1.35614734
92MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.35269887
93* GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.35100613
94TAF15_26573619_Chip-Seq_HEK293_Human1.33980027
95TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33269925
96CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.32316940
97KLF4_18555785_Chip-Seq_ESCs_Mouse1.32135519
98SOX2_18555785_Chip-Seq_ESCs_Mouse1.31895751
99E2F1_18555785_Chip-Seq_ESCs_Mouse1.31430042
100FLI1_21867929_ChIP-Seq_TH2_Mouse1.31165030
101* EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.31083481
102ESRRB_18555785_Chip-Seq_ESCs_Mouse1.29780451
103RAC3_21632823_ChIP-Seq_H3396_Human1.28096471
104* FOXP1_21924763_ChIP-Seq_HESCs_Human1.27802154
105* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.25815652
106GF1_26923725_Chip-Seq_HPCs_Mouse1.25633160
107SA1_27219007_Chip-Seq_Bcells_Human1.24922557
108VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.24268908
109PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.24199812
110GATA3_21867929_ChIP-Seq_CD8_Mouse1.23935755
111NMYC_18555785_Chip-Seq_ESCs_Mouse1.23513676
112PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.23255229
113GATA3_21878914_ChIP-Seq_MCF-7_Human1.20933473
114RNF2_27304074_Chip-Seq_NSC_Mouse1.20834162
115CTCF_18555785_Chip-Seq_ESCs_Mouse1.20234655
116OCT4_19829295_ChIP-Seq_ESCs_Human1.19950348
117CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.19765140
118E2F1_17053090_ChIP-ChIP_MCF-7_Human1.18840651
119SOX2_22085726_ChIP-Seq_NPCs_Mouse1.17934493
120RUNX1_27457419_Chip-Seq_LIVER_Mouse1.17343003
121GATA3_21867929_ChIP-Seq_TH1_Mouse1.16765732
122FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15548042
123PU1_27457419_Chip-Seq_LIVER_Mouse1.15348285
124SMAD4_21741376_ChIP-Seq_EPCs_Human1.15346208
125TP63_22573176_ChIP-Seq_HFKS_Human1.14543467
126SMAD1_18555785_Chip-Seq_ESCs_Mouse1.13701342
127STAT1_20625510_ChIP-Seq_HELA_Human1.12974786
128SOX9_26525672_Chip-Seq_HEART_Mouse1.12595769
129ERG_21242973_ChIP-ChIP_JURKAT_Human1.11974443
130ER_23166858_ChIP-Seq_MCF-7_Human1.11207733
131SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10685369
132MAF_26560356_Chip-Seq_TH2_Human1.10038899
133VDR_21846776_ChIP-Seq_THP-1_Human1.09183340
134ZFX_18555785_Chip-Seq_ESCs_Mouse1.09145901
135JARID2_20075857_ChIP-Seq_MESCs_Mouse1.08918420
136WDR5_24793694_ChIP-Seq_LNCAP_Human1.08854657
137UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08364042
138* AR_25329375_ChIP-Seq_VCAP_Human1.08263697
139JARID2_20064375_ChIP-Seq_MESCs_Mouse1.08101546
140GF1B_26923725_Chip-Seq_HPCs_Mouse1.07620769
141LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.06706952
142REST_21632747_ChIP-Seq_MESCs_Mouse1.06697214
143MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.06411586
144BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05903601
145PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.04855778
146TBL1_22424771_ChIP-Seq_293T_Human1.04812083
147TET1_21451524_ChIP-Seq_MESCs_Mouse1.04438178
148CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.04233482
149RUNX1_26923725_Chip-Seq_HPCs_Mouse1.03908568
150SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.02561215
151SALL1_21062744_ChIP-ChIP_HESCs_Human1.02357893
152EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02198747
153NFYB_21822215_ChIP-Seq_K562_Human1.01139155
154AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01127463
155SMRT_27268052_Chip-Seq_Bcells_Human1.00858323
156OCT1_27270436_Chip-Seq_PROSTATE_Human1.00851472
157RARA_24833708_ChIP-Seq_LIVER_Mouse1.00804680
158FUS_26573619_Chip-Seq_HEK293_Human0.99764362
159CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99688793
160P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.99354100
161* P53_21459846_ChIP-Seq_SAOS-2_Human0.98463240
162SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.98430469
163KLF4_19829295_ChIP-Seq_ESCs_Human0.98379323
164SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.97803561
165ESET_19884257_ChIP-Seq_ESCs_Mouse0.97625706
166TP53_20018659_ChIP-ChIP_R1E_Mouse0.97603290
167ERG_20517297_ChIP-Seq_VCAP_Human0.96834338
168RAD21_21589869_ChIP-Seq_MESCs_Mouse0.95018126
169RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.94728741
170MAF_26560356_Chip-Seq_TH1_Human0.94105218
171CTCF_21964334_ChIP-Seq_BJAB-B_Human0.93936121
172ETV2_25802403_ChIP-Seq_MESCs_Mouse0.93318874
173EZH2_18974828_ChIP-Seq_MESCs_Mouse0.93109493
174RNF2_18974828_ChIP-Seq_MESCs_Mouse0.93109493
175PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.92260733
176TAF2_19829295_ChIP-Seq_ESCs_Human0.91629691
177SOX2_21211035_ChIP-Seq_LN229_Human0.90629202
178SMAD4_21741376_ChIP-Seq_ESCs_Human0.90600671
179RNF2_27304074_Chip-Seq_ESCs_Mouse0.88295888
180TP53_22573176_ChIP-Seq_HFKS_Human0.88103466
181E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.87876557
182CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.87151649
183SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.86280262
184CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.86025772
185FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.85142553

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.35275074
2MP0001929_abnormal_gametogenesis4.93163884
3MP0005670_abnormal_white_adipose4.66980683
4MP0006292_abnormal_olfactory_placode4.21472326
5MP0004742_abnormal_vestibular_system4.07055817
6MP0008877_abnormal_DNA_methylation3.75271618
7MP0002210_abnormal_sex_determination3.20090755
8MP0002161_abnormal_fertility/fecundity2.87974047
9MP0003122_maternal_imprinting2.59352394
10MP0000383_abnormal_hair_follicle2.53276506
11MP0001145_abnormal_male_reproductive2.53260505
12MP0002653_abnormal_ependyma_morphology2.36436659
13MP0009278_abnormal_bone_marrow2.29076817
14MP0000653_abnormal_sex_gland2.28227339
15MP0003646_muscle_fatigue2.24674248
16MP0009053_abnormal_anal_canal2.20622243
17MP0001485_abnormal_pinna_reflex2.17624695
18MP0009379_abnormal_foot_pigmentation2.13082814
19MP0005410_abnormal_fertilization13.9724614
20MP0010030_abnormal_orbit_morphology1.97393439
21MP0005248_abnormal_Harderian_gland1.92274771
22MP0005666_abnormal_adipose_tissue1.80163905
23MP0002282_abnormal_trachea_morphology1.79478666
24MP0003011_delayed_dark_adaptation1.78165373
25MP0003121_genomic_imprinting1.73575926
26MP0008789_abnormal_olfactory_epithelium1.72454578
27MP0005499_abnormal_olfactory_system1.71477322
28MP0005394_taste/olfaction_phenotype1.71477322
29MP0001348_abnormal_lacrimal_gland1.61561824
30MP0005623_abnormal_meninges_morphology1.58022867
31MP0000026_abnormal_inner_ear1.55848312
32MP0009046_muscle_twitch1.47394742
33MP0005647_abnormal_sex_gland1.44369482
34MP0001188_hyperpigmentation1.43507575
35MP0005310_abnormal_salivary_gland1.39302120
36MP0001727_abnormal_embryo_implantation1.36845150
37MP0003879_abnormal_hair_cell1.36194551
38MP0000427_abnormal_hair_cycle1.34201389
39MP0004510_myositis1.32459032
40MP0002160_abnormal_reproductive_system1.29408195
41MP0001963_abnormal_hearing_physiology1.26971428
42MP0002876_abnormal_thyroid_physiology1.25180550
43MP0010678_abnormal_skin_adnexa1.22406156
44MP0000613_abnormal_salivary_gland1.21188690
45MP0000678_abnormal_parathyroid_gland1.20193285
46MP0002822_catalepsy1.17679828
47MP0000647_abnormal_sebaceous_gland1.12348006
48MP0009115_abnormal_fat_cell1.11293832
49MP0008875_abnormal_xenobiotic_pharmacok1.11066296
50MP0003950_abnormal_plasma_membrane1.09430159
51MP0001764_abnormal_homeostasis1.08613421
52MP0000566_synostosis1.08089049
53MP0005083_abnormal_biliary_tract1.06168687
54MP0008995_early_reproductive_senescence1.05606074
55MP0004130_abnormal_muscle_cell1.04441003
56MP0005377_hearing/vestibular/ear_phenot1.03571077
57MP0003878_abnormal_ear_physiology1.03571077
58MP0002009_preneoplasia1.00579158
59MP0009250_abnormal_appendicular_skeleto0.99749406
60MP0005174_abnormal_tail_pigmentation0.99699516
61MP0003136_yellow_coat_color0.97507106
62MP0002098_abnormal_vibrissa_morphology0.96166362
63MP0000750_abnormal_muscle_regeneration0.95302318
64MP0002132_abnormal_respiratory_system0.94606100
65MP0008058_abnormal_DNA_repair0.92700377
66MP0001986_abnormal_taste_sensitivity0.91933737
67MP0002971_abnormal_brown_adipose0.91184135
68MP0001286_abnormal_eye_development0.91143328
69MP0005646_abnormal_pituitary_gland0.91139514
70MP0005375_adipose_tissue_phenotype0.90645353
71MP0000778_abnormal_nervous_system0.90246967
72MP0005365_abnormal_bile_salt0.89188661
73MP0000462_abnormal_digestive_system0.89038963
74MP0004957_abnormal_blastocyst_morpholog0.88264340
75MP0001486_abnormal_startle_reflex0.87014768
76MP0002938_white_spotting0.86750576
77MP0000049_abnormal_middle_ear0.86555168
78MP0003718_maternal_effect0.81030651
79MP0005391_vision/eye_phenotype0.80640822
80MP0003690_abnormal_glial_cell0.80395680
81MP0001765_abnormal_ion_homeostasis0.79027671
82MP0001984_abnormal_olfaction0.78583404
83MP0001270_distended_abdomen0.76750057
84MP0004019_abnormal_vitamin_homeostasis0.76488158
85MP0004885_abnormal_endolymph0.75975472
86MP0001119_abnormal_female_reproductive0.75507961
87MP0002295_abnormal_pulmonary_circulatio0.75086645
88MP0002735_abnormal_chemical_nociception0.74972865
89MP0003699_abnormal_female_reproductive0.74052000
90MP0008260_abnormal_autophagy0.74043094
91MP0002067_abnormal_sensory_capabilities0.73694378
92MP0002557_abnormal_social/conspecific_i0.73152868
93MP0000470_abnormal_stomach_morphology0.71829212
94MP0010329_abnormal_lipoprotein_level0.71626181
95MP0002139_abnormal_hepatobiliary_system0.71480692
96MP0003119_abnormal_digestive_system0.71404148
97MP0004185_abnormal_adipocyte_glucose0.70513925
98MP0001346_abnormal_lacrimal_gland0.70480967
99MP0005389_reproductive_system_phenotype0.70314001
100MP0009697_abnormal_copulation0.70095232
101MP0002092_abnormal_eye_morphology0.69098449
102MP0002163_abnormal_gland_morphology0.69057809
103MP0000428_abnormal_craniofacial_morphol0.68575419
104MP0002234_abnormal_pharynx_morphology0.68534802
105MP0000631_abnormal_neuroendocrine_gland0.68398369
106MP0003861_abnormal_nervous_system0.66738458
107MP0005503_abnormal_tendon_morphology0.64867945
108MP0004859_abnormal_synaptic_plasticity0.64504221
109MP0001324_abnormal_eye_pigmentation0.64232793
110MP0002697_abnormal_eye_size0.63879381
111MP0002118_abnormal_lipid_homeostasis0.63683151
112MP0005334_abnormal_fat_pad0.63271434
113MP0002184_abnormal_innervation0.61357422
114MP0005195_abnormal_posterior_eye0.60915884
115MP0006138_congestive_heart_failure0.59872369
116MP0003279_aneurysm0.59617650
117MP0001968_abnormal_touch/_nociception0.59045847
118MP0003938_abnormal_ear_development0.58329742
119MP0005388_respiratory_system_phenotype0.58116438
120MP0002133_abnormal_respiratory_system0.58116438
121MP0002249_abnormal_larynx_morphology0.57859127
122MP0000955_abnormal_spinal_cord0.56511144
123MP0001661_extended_life_span0.56131099
124MP0005332_abnormal_amino_acid0.55737488
125MP0002752_abnormal_somatic_nervous0.55561322
126MP0005551_abnormal_eye_electrophysiolog0.53225614
127MP0004134_abnormal_chest_morphology0.53149366
128MP0002736_abnormal_nociception_after0.51447945
129MP0001905_abnormal_dopamine_level0.51214589
130MP0003137_abnormal_impulse_conducting0.50628443
131MP0005076_abnormal_cell_differentiation0.50293157
132MP0003787_abnormal_imprinting0.50063877
133MP0005636_abnormal_mineral_homeostasis0.49255582
134MP0004197_abnormal_fetal_growth/weight/0.49130768
135MP0008872_abnormal_physiological_respon0.48552032
136MP0003633_abnormal_nervous_system0.48098063
137MP0005379_endocrine/exocrine_gland_phen0.47820394
138MP0003941_abnormal_skin_development0.46629854
139MP0005257_abnormal_intraocular_pressure0.45598612
140MP0005360_urolithiasis0.45530174
141MP0003115_abnormal_respiratory_system0.44646941
142MP0003959_abnormal_lean_body0.43236979
143MP0003786_premature_aging0.42950470
144MP0009384_cardiac_valve_regurgitation0.42066379
145MP0005253_abnormal_eye_physiology0.41694865
146MP0002837_dystrophic_cardiac_calcinosis0.40649438
147MP0002102_abnormal_ear_morphology0.39590796
148MP0005085_abnormal_gallbladder_physiolo0.39069079
149MP0005423_abnormal_somatic_nervous0.38311745
150MP0006036_abnormal_mitochondrial_physio0.36668114
151MP0005535_abnormal_body_temperature0.36600048
152MP0002970_abnormal_white_adipose0.36379571
153MP0001293_anophthalmia0.35830224
154MP0003948_abnormal_gas_homeostasis0.35559178
155MP0003631_nervous_system_phenotype0.35382853
156MP0005645_abnormal_hypothalamus_physiol0.35129919
157MP0001177_atelectasis0.35061894
158MP0005451_abnormal_body_composition0.34075726
159MP0002109_abnormal_limb_morphology0.33681198
160MP0005319_abnormal_enzyme/_coenzyme0.33404537
161MP0003186_abnormal_redox_activity0.31221849
162MP0002115_abnormal_skeleton_extremities0.30758376
163MP0005395_other_phenotype0.29722922
164MP0000534_abnormal_ureter_morphology0.29235580
165MP0004043_abnormal_pH_regulation0.29146578
166MP0001502_abnormal_circadian_rhythm0.29091968
167MP0002638_abnormal_pupillary_reflex0.28577309
168MP0000516_abnormal_urinary_system0.27011628
169MP0005367_renal/urinary_system_phenotyp0.27011628

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.64415594
2Abnormal respiratory motile cilium morphology (HP:0005938)8.20366330
3Abnormal respiratory epithelium morphology (HP:0012253)8.20366330
4Abnormal ciliary motility (HP:0012262)7.14287351
5Rhinitis (HP:0012384)6.90637791
6Amblyopia (HP:0000646)6.44117590
7Chronic bronchitis (HP:0004469)6.18702470
8Abnormality of the parathyroid morphology (HP:0011766)5.91663011
9Infertility (HP:0000789)5.67247737
10Severe visual impairment (HP:0001141)4.96561888
11Autoamputation (HP:0001218)4.89309875
12Abnormality of the aortic arch (HP:0012303)4.59225431
13Nasal polyposis (HP:0100582)4.57522657
14Renal Fanconi syndrome (HP:0001994)4.44346062
15Male infertility (HP:0003251)4.21895630
16Bony spicule pigmentary retinopathy (HP:0007737)4.21873353
17Abnormal spermatogenesis (HP:0008669)3.91003367
18Poor speech (HP:0002465)3.87191501
19Nephronophthisis (HP:0000090)3.81934728
20Increased hepatocellular lipid droplets (HP:0006565)3.79173278
21Cerebellar dysplasia (HP:0007033)3.73064255
22Bronchiectasis (HP:0002110)3.70330087
23Attenuation of retinal blood vessels (HP:0007843)3.67213112
24Abnormality of the nasal mucosa (HP:0000433)3.63131630
25Bronchitis (HP:0012387)3.53912636
26Osteolytic defects of the phalanges of the hand (HP:0009771)3.50956442
27Osteolytic defects of the hand bones (HP:0009699)3.50956442
28Rib fusion (HP:0000902)3.50661603
29Lipid accumulation in hepatocytes (HP:0006561)3.26707638
30Tubulointerstitial nephritis (HP:0001970)3.14192404
31Recurrent sinusitis (HP:0011108)3.12575146
32Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.02096033
33Abnormality of the renal medulla (HP:0100957)2.98721212
34Azoospermia (HP:0000027)2.96043891
35Recurrent otitis media (HP:0000403)2.93461072
36Abnormal rod and cone electroretinograms (HP:0008323)2.89959183
37Hyperkalemia (HP:0002153)2.79689711
38Nephroblastoma (Wilms tumor) (HP:0002667)2.76924339
39Esotropia (HP:0000565)2.75613472
40Aplasia/Hypoplasia of the sacrum (HP:0008517)2.73513243
41Abnormality of midbrain morphology (HP:0002418)2.65488771
42Molar tooth sign on MRI (HP:0002419)2.65488771
43Medial flaring of the eyebrow (HP:0010747)2.65114222
44Genetic anticipation (HP:0003743)2.61280989
45Exertional dyspnea (HP:0002875)2.59877549
46Progressive cerebellar ataxia (HP:0002073)2.57210960
47Ectopic kidney (HP:0000086)2.52731557
48Short 4th metacarpal (HP:0010044)2.52421928
49Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.52421928
50Embryonal renal neoplasm (HP:0011794)2.52393533
51Respiratory difficulties (HP:0002880)2.51849820
52Abnormality of the 4th metacarpal (HP:0010012)2.50200837
53Impulsivity (HP:0100710)2.46517008
54Fibular hypoplasia (HP:0003038)2.45728483
55Tubulointerstitial abnormality (HP:0001969)2.38252348
56Congenital stationary night blindness (HP:0007642)2.38114370
57Reticulocytopenia (HP:0001896)2.37907100
58Facial hemangioma (HP:0000329)2.33070148
59Postaxial foot polydactyly (HP:0001830)2.32198743
60Glycosuria (HP:0003076)2.27890952
61Abnormality of urine glucose concentration (HP:0011016)2.27890952
62Tubular atrophy (HP:0000092)2.23850029
63Pancreatic fibrosis (HP:0100732)2.22332962
64Abnormal biliary tract physiology (HP:0012439)2.19988820
65Bile duct proliferation (HP:0001408)2.19988820
66Aplasia/Hypoplasia of the earlobes (HP:0009906)2.18607164
67Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.16177827
68Abnormal number of erythroid precursors (HP:0012131)2.13734594
69Increased intramyocellular lipid droplets (HP:0012240)2.13478730
70Abnormality of the dental root (HP:0006486)2.12425111
71Taurodontia (HP:0000679)2.12425111
72Abnormality of permanent molar morphology (HP:0011071)2.12425111
73True hermaphroditism (HP:0010459)2.12257143
74Abnormality of cells of the erythroid lineage (HP:0012130)2.09425539
75Hyperventilation (HP:0002883)2.05814459
76Abnormality of molar (HP:0011077)2.04356422
77Abnormality of molar morphology (HP:0011070)2.04356422
78Embryonal neoplasm (HP:0002898)2.02594210
79Hyperphosphaturia (HP:0003109)2.02440697
80Abnormality of the dental pulp (HP:0006479)2.00914104
81Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.2260528
82Dynein arm defect of respiratory motile cilia (HP:0012255)11.8333056
83Absent/shortened dynein arms (HP:0200106)11.8333056
84Failure to thrive in infancy (HP:0001531)1.99838998
85Growth hormone deficiency (HP:0000824)1.99065809
86Intellectual disability, severe (HP:0010864)1.98416454
87Occipital encephalocele (HP:0002085)1.97555088
88Hypoplastic ischia (HP:0003175)1.96125831
89Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.95879660
90Gonadotropin excess (HP:0000837)1.93576649
91Hamartoma (HP:0010566)1.93013003
92Tongue fasciculations (HP:0001308)1.92823336
93Optic nerve hypoplasia (HP:0000609)1.92462593
94Irregular epiphyses (HP:0010582)1.92433852
95Abnormality of dental color (HP:0011073)1.89329930
96Retinal atrophy (HP:0001105)1.89240116
97Abnormal urine phosphate concentration (HP:0012599)1.89078170
98Bilateral microphthalmos (HP:0007633)1.88656222
99Abnormality of the hepatic vasculature (HP:0006707)1.86820163
100Abnormality of macular pigmentation (HP:0008002)1.85741785
1013-Methylglutaconic aciduria (HP:0003535)1.85188008
102Aplasia/Hypoplasia of the fibula (HP:0006492)1.84419206
103Absent epiphyses (HP:0010577)1.84223276
104Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.84223276
105Renal dysplasia (HP:0000110)1.81417970
106Vascular calcification (HP:0004934)1.81158827
107Abnormality of renal excretion (HP:0011036)1.80829479
108Colon cancer (HP:0003003)1.80706389
109Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.80163834
110Oligodactyly (HP:0012165)1.79887908
111Decreased central vision (HP:0007663)1.79111978
112Bell-shaped thorax (HP:0001591)1.77490972
113Congenital hepatic fibrosis (HP:0002612)1.77472018
114Recurrent bronchitis (HP:0002837)1.77386081
115Hyperparathyroidism (HP:0000843)1.77045739
116Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.76303893
117Abnormality of the renal cortex (HP:0011035)1.75727861
118Polyuria (HP:0000103)1.74477116
119Annular pancreas (HP:0001734)1.74042002
120Stage 5 chronic kidney disease (HP:0003774)1.73545683
121Anterior segment dysgenesis (HP:0007700)1.73389505
122Anophthalmia (HP:0000528)1.73357128
123Increased muscle lipid content (HP:0009058)1.71823851
124Hypoplasia of the capital femoral epiphysis (HP:0003090)1.71543518
125Muscle fibrillation (HP:0010546)1.71070983
126Tubulointerstitial fibrosis (HP:0005576)1.71067431
127Microglossia (HP:0000171)1.70090753
128Mitochondrial inheritance (HP:0001427)1.69347739
129Macular degeneration (HP:0000608)1.68614538
130Enlarged epiphyses (HP:0010580)1.68097574
131Anencephaly (HP:0002323)1.67974773
132Chronic hepatic failure (HP:0100626)1.67294983
133Methylmalonic acidemia (HP:0002912)1.67055934
134Hypoplasia of the thymus (HP:0000778)1.65927942
135Aplasia/Hypoplasia of the tongue (HP:0010295)1.65806910
136Tapered finger (HP:0001182)1.65738919
137Osteomyelitis (HP:0002754)1.64198044
138Cardiovascular calcification (HP:0011915)1.64115555
139Aplasia/Hypoplasia of the lens (HP:0008063)1.64059100
140Optic nerve coloboma (HP:0000588)1.62229880
141Short femoral neck (HP:0100864)1.62097367
142Short ribs (HP:0000773)1.61584112
143Abnormality of the ischium (HP:0003174)1.61489211
144Postural instability (HP:0002172)1.61081307
145Insulin-resistant diabetes mellitus (HP:0000831)1.59624840
146Pancreatic cysts (HP:0001737)1.56727020
147Postaxial hand polydactyly (HP:0001162)1.51555651
148Hyperglycinuria (HP:0003108)1.51411781
149Polydipsia (HP:0001959)1.50063943
150Abnormal drinking behavior (HP:0030082)1.50063943
151Congenital primary aphakia (HP:0007707)1.48661376
152Gait imbalance (HP:0002141)1.45093681
153Nephropathy (HP:0000112)1.43069703
154Double outlet right ventricle (HP:0001719)1.42430424
155Congenital malformation of the right heart (HP:0011723)1.42430424
156Epiphyseal dysplasia (HP:0002656)1.41523187
157Aplasia involving bones of the upper limbs (HP:0009823)1.40889569
158Aplasia of the phalanges of the hand (HP:0009802)1.40889569
159Aplasia involving bones of the extremities (HP:0009825)1.40889569
160Abnormality of renal resorption (HP:0011038)1.40782954
161Hyperglycinemia (HP:0002154)1.38554274
162Cholecystitis (HP:0001082)1.38428764
163Abnormal gallbladder physiology (HP:0012438)1.38428764
164Vitreoretinal degeneration (HP:0000655)1.36704466
165Neonatal hypoglycemia (HP:0001998)1.36631181
166Abnormal urine output (HP:0012590)1.36329002
167Cystic liver disease (HP:0006706)1.35349840
168Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.35133841
169Median cleft lip (HP:0000161)1.34491647
170Poor coordination (HP:0002370)1.33985379
171Methylmalonic aciduria (HP:0012120)1.33567048
172Small epiphyses (HP:0010585)1.30789875
173Abnormality of serine family amino acid metabolism (HP:0010894)1.29573037
174Abnormality of glycine metabolism (HP:0010895)1.29573037
175Nephrogenic diabetes insipidus (HP:0009806)1.29035746
176Short thorax (HP:0010306)1.28723111

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.96090984
2PDK38.96090984
3PDK27.09164085
4WEE16.42898342
5TESK13.42687415
6VRK23.31736166
7PRKD33.05031094
8MAP3K102.85131962
9SMG12.53424103
10TAF12.49810681
11ICK2.11020685
12STK38L2.05861934
13CDK41.93362037
14BRD41.80908480
15PTK2B1.78594721
16BMPR1B1.66876170
17WNK41.57584017
18SIK21.52425725
19STK391.43170105
20UHMK11.23542093
21STK381.18834709
22PDK11.07076506
23EPHB21.06470073
24NEK61.05999846
25AURKA0.99824332
26MUSK0.99167264
27STK30.98232075
28AKT30.96233971
29PINK10.93524090
30VRK10.89790044
31ZAK0.89476821
32IRAK30.86130191
33HIPK20.85795322
34LATS10.82368608
35STK240.78802740
36RPS6KA10.78206571
37LMTK20.76966417
38IRAK10.75079360
39CHEK20.74316486
40PLK40.71859275
41MAP2K70.70653446
42DYRK1B0.70439862
43GRK70.68965101
44NEK20.66789219
45CDC70.64969362
46CDK70.64085148
47NEK90.62523609
48MAP4K20.62329831
49MAP3K130.61476934
50MAP3K110.60684464
51WNK10.60182930
52WNK30.60010930
53PDPK10.59619013
54TTK0.58369787
55INSRR0.56813724
56MAP3K70.52743890
57EPHA30.52330065
58BRAF0.52327716
59MKNK10.52315985
60MARK30.47046423
61TNK20.46426216
62BCKDK0.45723399
63MARK10.44466809
64MAPKAPK50.44068801
65CDK120.43050773
66SGK20.42157261
67OBSCN0.42136531
68RPS6KA60.40367323
69BRSK20.39536134
70YES10.39228200
71CASK0.39103017
72CAMK1G0.37608135
73RPS6KL10.37529711
74RPS6KC10.37529711
75RPS6KA40.37339214
76RIPK40.37111040
77CAMK10.37080596
78PNCK0.36893020
79STK110.36850714
80PBK0.35358800
81MKNK20.34971296
82NUAK10.34515647
83PRKCG0.33063383
84CDK20.32980755
85PRKAA20.32822389
86MAP3K30.32453487
87PKN10.32344679
88TNIK0.32209676
89CHEK10.31977883
90CDK30.31476959
91DDR20.31366460
92SGK2230.31088050
93SGK4940.31088050
94PRPF4B0.30633451
95NTRK20.29862027
96TYRO30.29599100
97TAOK10.29081980
98LATS20.28945224
99FGR0.27903053
100CDK10.27772385
101CSNK1D0.27705638
102MAPK120.27327690
103MAPK150.26971955
104TAOK30.26556196
105MAPK140.26235655
106ERBB40.26079978
107GRK10.25767687
108PRKAA10.24599000
109DYRK30.24272776
110MAPK70.23709855
111EIF2AK20.23663015
112FRK0.23527806
113IRAK20.23289557
114CDK90.23108139
115ADRBK20.22769843
116IGF1R0.22325517
117MAP2K40.22179309
118CAMK1D0.21771276
119CDK50.21226717
120PRKG20.20888145
121PAK10.20449235
122PRKACG0.20369808
123CAMK40.20115487
124AKT10.20080696
125RPS6KB10.19716924
126PRKCZ0.19540899
127ATM0.19522360
128ATR0.19292051
129MELK0.18665474
130PLK20.17824269
131PLK10.17778860
132BLK0.17709147
133RPS6KA20.17504415
134MAP2K60.17269472
135JAK30.17206098
136TXK0.16908955
137PLK30.15892401
138GRK50.14938827
139SRPK10.14541435
140SGK10.13775323
141CCNB10.13660110
142SGK30.13333249
143NME10.12940623
144PRKG10.12858000
145GSK3B0.12521110
146PRKD20.11234027
147PIM10.10996308
148BRSK10.10673146
149GRK60.10577755
150MAPK80.10359560
151GSK3A0.10301857
152PRKACA0.09917885
153MAPK10.09619904
154DYRK20.09592579
155ERBB30.09206542
156MTOR0.09030296

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000615.47952043
2Vitamin B6 metabolism_Homo sapiens_hsa007504.58472530
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.55364307
4Propanoate metabolism_Homo sapiens_hsa006404.14246948
5Regulation of autophagy_Homo sapiens_hsa041404.11442437
6Pyruvate metabolism_Homo sapiens_hsa006203.26919395
7Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.17841170
8PPAR signaling pathway_Homo sapiens_hsa033202.96925542
9Ribosome_Homo sapiens_hsa030102.88196810
10Fatty acid metabolism_Homo sapiens_hsa012122.77560897
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.64466048
12Linoleic acid metabolism_Homo sapiens_hsa005912.46995706
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.36884567
14Fatty acid degradation_Homo sapiens_hsa000712.28086259
15Glycerolipid metabolism_Homo sapiens_hsa005612.23662620
16Cell cycle_Homo sapiens_hsa041102.19825123
17RNA polymerase_Homo sapiens_hsa030202.15380517
18Olfactory transduction_Homo sapiens_hsa047402.12177230
19Phototransduction_Homo sapiens_hsa047441.91859299
20Type II diabetes mellitus_Homo sapiens_hsa049301.90179680
21Glycerophospholipid metabolism_Homo sapiens_hsa005641.87774705
22Sulfur relay system_Homo sapiens_hsa041221.86986127
23Pentose phosphate pathway_Homo sapiens_hsa000301.85144836
24Base excision repair_Homo sapiens_hsa034101.85011655
25Glucagon signaling pathway_Homo sapiens_hsa049221.80388449
26Basal transcription factors_Homo sapiens_hsa030221.76372486
27Carbon metabolism_Homo sapiens_hsa012001.74508998
28Notch signaling pathway_Homo sapiens_hsa043301.71746645
29ABC transporters_Homo sapiens_hsa020101.70322184
30Homologous recombination_Homo sapiens_hsa034401.69132870
31Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.62144102
32Fructose and mannose metabolism_Homo sapiens_hsa000511.56859739
33Taste transduction_Homo sapiens_hsa047421.54743356
34Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.51908287
35Ether lipid metabolism_Homo sapiens_hsa005651.43623649
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.38776106
37Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.34068245
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.33581861
39Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.27687860
40Vitamin digestion and absorption_Homo sapiens_hsa049771.22345713
41Mineral absorption_Homo sapiens_hsa049781.22000206
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.19422796
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.14003733
44Biosynthesis of amino acids_Homo sapiens_hsa012301.13604408
45Arachidonic acid metabolism_Homo sapiens_hsa005901.13340369
46Peroxisome_Homo sapiens_hsa041461.12280788
47Oxidative phosphorylation_Homo sapiens_hsa001901.09878526
48Fat digestion and absorption_Homo sapiens_hsa049751.09626509
49Fatty acid elongation_Homo sapiens_hsa000621.07550628
50Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.04857305
51Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.04628346
52Fanconi anemia pathway_Homo sapiens_hsa034601.00969431
53Cysteine and methionine metabolism_Homo sapiens_hsa002700.97861524
54Antigen processing and presentation_Homo sapiens_hsa046120.94613307
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.93020219
56Purine metabolism_Homo sapiens_hsa002300.89165737
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87900673
58Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.87703089
59beta-Alanine metabolism_Homo sapiens_hsa004100.86655751
60Morphine addiction_Homo sapiens_hsa050320.86014683
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.85845822
62Nitrogen metabolism_Homo sapiens_hsa009100.85786191
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.85556525
64Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.84717648
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.84553385
66Retinol metabolism_Homo sapiens_hsa008300.83269381
67Glutathione metabolism_Homo sapiens_hsa004800.83127307
68Glycosaminoglycan degradation_Homo sapiens_hsa005310.82447105
69Circadian entrainment_Homo sapiens_hsa047130.80985168
70Oocyte meiosis_Homo sapiens_hsa041140.80447525
71Renin-angiotensin system_Homo sapiens_hsa046140.79444461
72Chemical carcinogenesis_Homo sapiens_hsa052040.79239647
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.77706619
74Parkinsons disease_Homo sapiens_hsa050120.76578818
75DNA replication_Homo sapiens_hsa030300.73256290
76Lysine degradation_Homo sapiens_hsa003100.72760762
77Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.72709470
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71039842
79Huntingtons disease_Homo sapiens_hsa050160.69743611
80Renin secretion_Homo sapiens_hsa049240.69512652
81Pyrimidine metabolism_Homo sapiens_hsa002400.68859209
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.67934074
83Bile secretion_Homo sapiens_hsa049760.67628834
84Metabolic pathways_Homo sapiens_hsa011000.67006373
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66506909
86Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.66349453
87Wnt signaling pathway_Homo sapiens_hsa043100.63093449
88Cardiac muscle contraction_Homo sapiens_hsa042600.62685295
89Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.62041182
90Cholinergic synapse_Homo sapiens_hsa047250.61479361
91Protein digestion and absorption_Homo sapiens_hsa049740.60495649
92Viral carcinogenesis_Homo sapiens_hsa052030.59813489
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59426762
94Hedgehog signaling pathway_Homo sapiens_hsa043400.59224648
95Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.56306002
96Graft-versus-host disease_Homo sapiens_hsa053320.55140869
97Serotonergic synapse_Homo sapiens_hsa047260.54530580
98Phenylalanine metabolism_Homo sapiens_hsa003600.53830065
99Amphetamine addiction_Homo sapiens_hsa050310.53635990
100Selenocompound metabolism_Homo sapiens_hsa004500.52638016
101Allograft rejection_Homo sapiens_hsa053300.52276079
102Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51552177
103Axon guidance_Homo sapiens_hsa043600.51326173
104mTOR signaling pathway_Homo sapiens_hsa041500.51025926
105Maturity onset diabetes of the young_Homo sapiens_hsa049500.50524038
106Sphingolipid metabolism_Homo sapiens_hsa006000.49624567
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49395758
108Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48548677
109Mismatch repair_Homo sapiens_hsa034300.47973815
110Glutamatergic synapse_Homo sapiens_hsa047240.47637536
111Aldosterone synthesis and secretion_Homo sapiens_hsa049250.45261692
112Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.45247501
113Dorso-ventral axis formation_Homo sapiens_hsa043200.44901206
114Epstein-Barr virus infection_Homo sapiens_hsa051690.43330919
115Pancreatic secretion_Homo sapiens_hsa049720.43329010
116Spliceosome_Homo sapiens_hsa030400.42809182
117Salivary secretion_Homo sapiens_hsa049700.42234084
118Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.41902001
119Sulfur metabolism_Homo sapiens_hsa009200.41857210
120Melanogenesis_Homo sapiens_hsa049160.41494760
121Legionellosis_Homo sapiens_hsa051340.40716767
122Alzheimers disease_Homo sapiens_hsa050100.39847701
123Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39843356
124Steroid hormone biosynthesis_Homo sapiens_hsa001400.39516589
125MAPK signaling pathway_Homo sapiens_hsa040100.38523099
126Complement and coagulation cascades_Homo sapiens_hsa046100.38226390
127Ovarian steroidogenesis_Homo sapiens_hsa049130.38017297
128Butanoate metabolism_Homo sapiens_hsa006500.37760512
129Nucleotide excision repair_Homo sapiens_hsa034200.36942660
130Steroid biosynthesis_Homo sapiens_hsa001000.36338384
131Autoimmune thyroid disease_Homo sapiens_hsa053200.35736513
132Type I diabetes mellitus_Homo sapiens_hsa049400.35385488
133Tyrosine metabolism_Homo sapiens_hsa003500.34896060
134Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33803093
135Collecting duct acid secretion_Homo sapiens_hsa049660.32069954
136Histidine metabolism_Homo sapiens_hsa003400.31948425
137Calcium signaling pathway_Homo sapiens_hsa040200.30706827
138Nicotine addiction_Homo sapiens_hsa050330.30371111
139Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.30148162
140Inositol phosphate metabolism_Homo sapiens_hsa005620.29583598
141AMPK signaling pathway_Homo sapiens_hsa041520.29374269
142Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.28389825
143Thyroid hormone synthesis_Homo sapiens_hsa049180.26824149
144Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.26609626
145RNA transport_Homo sapiens_hsa030130.25914396
146mRNA surveillance pathway_Homo sapiens_hsa030150.24681433
147Rheumatoid arthritis_Homo sapiens_hsa053230.24151244
148Primary bile acid biosynthesis_Homo sapiens_hsa001200.22434430
149cAMP signaling pathway_Homo sapiens_hsa040240.21400148
150Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.20472192
151cGMP-PKG signaling pathway_Homo sapiens_hsa040220.19241492
152Tryptophan metabolism_Homo sapiens_hsa003800.18986870
153RNA degradation_Homo sapiens_hsa030180.18902685
154Insulin secretion_Homo sapiens_hsa049110.18733674
155Basal cell carcinoma_Homo sapiens_hsa052170.17546535

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