PROCR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. The encoded protein may also play a role in malarial infection and has been associated with cancer. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.08597859
2lymphangiogenesis (GO:0001946)5.33767055
3blood vessel maturation (GO:0001955)5.20879668
4response to interferon-alpha (GO:0035455)5.09214227
5endothelium development (GO:0003158)4.72416263
6retina vasculature morphogenesis in camera-type eye (GO:0061299)4.66031794
7response to interferon-beta (GO:0035456)4.56443227
8T-helper 1 type immune response (GO:0042088)4.43434828
9response to type I interferon (GO:0034340)4.41408321
10type I interferon signaling pathway (GO:0060337)4.41381820
11cellular response to type I interferon (GO:0071357)4.41381820
12cellular response to zinc ion (GO:0071294)4.41020438
13positive regulation of interferon-alpha production (GO:0032727)4.25378695
14antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.23301180
15antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.23301180
16negative regulation of viral genome replication (GO:0045071)4.10593137
17endothelial cell morphogenesis (GO:0001886)4.09671024
18proteasome assembly (GO:0043248)4.04736183
19regulation of interferon-alpha production (GO:0032647)4.00998590
20cell adhesion mediated by integrin (GO:0033627)3.97621432
21regulation of chemokine biosynthetic process (GO:0045073)3.96304806
22positive regulation of natural killer cell differentiation (GO:0032825)3.90659112
23antigen processing and presentation of endogenous antigen (GO:0019883)3.88622554
24neutrophil activation involved in immune response (GO:0002283)3.85476208
25positive regulation of gamma-delta T cell activation (GO:0046645)3.81356170
26positive regulation of chemokine biosynthetic process (GO:0045080)3.76581420
27response to peptidoglycan (GO:0032494)3.72376899
28natural killer cell activation involved in immune response (GO:0002323)3.72162040
29hemidesmosome assembly (GO:0031581)3.71579449
30wound healing, spreading of cells (GO:0044319)3.61264106
31lipopolysaccharide-mediated signaling pathway (GO:0031663)3.60269442
32substrate-dependent cell migration (GO:0006929)3.55906436
33modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.54371475
34positive regulation by organism of defense response of other organism involved in symbiotic interact3.54371475
35modulation by symbiont of host immune response (GO:0052553)3.54371475
36positive regulation by symbiont of host defense response (GO:0052509)3.54371475
37modulation by symbiont of host defense response (GO:0052031)3.54371475
38modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.54371475
39defense response to protozoan (GO:0042832)3.48276867
40regulation of RIG-I signaling pathway (GO:0039535)3.46895521
41immunoglobulin mediated immune response (GO:0016064)3.42260386
42endothelial cell proliferation (GO:0001935)3.41646898
43positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.41353574
44regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.41353574
45artery development (GO:0060840)3.37845301
46response to protozoan (GO:0001562)3.33931015
47vascular endothelial growth factor signaling pathway (GO:0038084)3.32042975
48regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.31714790
49mature B cell differentiation involved in immune response (GO:0002313)3.30105467
50endothelial tube morphogenesis (GO:0061154)3.29734805
51morphogenesis of an endothelium (GO:0003159)3.29734805
52myeloid dendritic cell differentiation (GO:0043011)3.28057870
53positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.27836957
54B cell mediated immunity (GO:0019724)3.26391433
55negative regulation of nitric-oxide synthase activity (GO:0051001)3.24991276
56cellular response to cadmium ion (GO:0071276)3.24513950
57cellular response to interferon-beta (GO:0035458)3.23745866
58mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.22901110
59detection of molecule of bacterial origin (GO:0032490)3.22709242
60ganglion development (GO:0061548)3.22600843
61protein maturation by protein folding (GO:0022417)3.20826826
62positive regulation of interferon-beta production (GO:0032728)3.20545581
63sprouting angiogenesis (GO:0002040)3.19536547
64ribosomal small subunit biogenesis (GO:0042274)3.19270496
65positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.19138692
66regulation of interleukin-12 biosynthetic process (GO:0045075)3.17822726
67regulation of interferon-beta biosynthetic process (GO:0045357)3.16887310
68positive regulation of osteoblast proliferation (GO:0033690)3.15945052
69regulation of T-helper 1 cell differentiation (GO:0045625)3.14709458
70regulation of metalloenzyme activity (GO:0048552)3.14622680
71endodermal cell differentiation (GO:0035987)3.14377938
72natural killer cell mediated cytotoxicity (GO:0042267)3.14285247
73natural killer cell mediated immunity (GO:0002228)3.14285247
74chondrocyte proliferation (GO:0035988)3.13841385
75interferon-gamma-mediated signaling pathway (GO:0060333)3.12118399
76ribosomal large subunit biogenesis (GO:0042273)3.10403665
77regulation of natural killer cell differentiation (GO:0032823)3.09433415
78maturation of SSU-rRNA (GO:0030490)3.07385038
79cellular response to interferon-alpha (GO:0035457)3.07243027
80antigen processing and presentation via MHC class Ib (GO:0002475)3.06483364
81axon extension involved in axon guidance (GO:0048846)3.05291765
82neuron projection extension involved in neuron projection guidance (GO:1902284)3.05291765
83negative regulation of interleukin-17 production (GO:0032700)3.02826485
84superoxide anion generation (GO:0042554)3.01484367
85regulation of activation of Janus kinase activity (GO:0010533)3.00140633
86regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.99949548
87regulation of fever generation (GO:0031620)2.99555125
88negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.99154776
89negative regulation of chondrocyte differentiation (GO:0032331)2.99017028
90ATP synthesis coupled proton transport (GO:0015986)2.98922263
91energy coupled proton transport, down electrochemical gradient (GO:0015985)2.98922263
92positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.98132970
93endothelial cell chemotaxis (GO:0035767)2.95937857
94cellular response to exogenous dsRNA (GO:0071360)2.95508898
95mature B cell differentiation (GO:0002335)2.95211926
96positive regulation of interleukin-12 production (GO:0032735)2.94972593
97positive regulation of NF-kappaB import into nucleus (GO:0042346)2.94849644
98respiratory burst (GO:0045730)2.94061327
99positive regulation of heat generation (GO:0031652)2.93034368
100granulocyte activation (GO:0036230)2.92166355
101cell migration involved in sprouting angiogenesis (GO:0002042)2.91572859
102response to muramyl dipeptide (GO:0032495)2.91462281
103detection of other organism (GO:0098543)2.90417120
104pseudouridine synthesis (GO:0001522)2.88896079
105myeloid dendritic cell activation (GO:0001773)2.88550714
106positive regulation of endothelial cell differentiation (GO:0045603)2.88365662
107negative regulation of erythrocyte differentiation (GO:0045647)2.85250864
108establishment of protein localization to mitochondrial membrane (GO:0090151)2.84866095
109vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.83019904
110positive regulation of interleukin-17 production (GO:0032740)2.82588118
111hyaluronan catabolic process (GO:0030214)2.81968474
112apoptotic cell clearance (GO:0043277)2.81772242
113response to exogenous dsRNA (GO:0043330)2.81016892
114negative regulation of myeloid cell apoptotic process (GO:0033033)2.80166247
115production of molecular mediator involved in inflammatory response (GO:0002532)2.79128210
116regulation of dendritic cell antigen processing and presentation (GO:0002604)2.78372401
117Peyers patch development (GO:0048541)2.78270199
118mucosal-associated lymphoid tissue development (GO:0048537)2.78270199
119macrophage activation involved in immune response (GO:0002281)2.77717917
120SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.76666712
121natural killer cell activation (GO:0030101)2.76454894
122response to host immune response (GO:0052572)2.76377881
123response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.76377881
124cotranslational protein targeting to membrane (GO:0006613)2.74792796
125neutrophil activation (GO:0042119)2.74604899
126positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.72440375
127detection of external biotic stimulus (GO:0098581)2.72434857
128platelet dense granule organization (GO:0060155)2.71887077
129regulation of interleukin-17 production (GO:0032660)2.70738112
130protein targeting to ER (GO:0045047)2.69628953
131rRNA modification (GO:0000154)2.69376382
132angiogenesis involved in wound healing (GO:0060055)2.68225273
133negative regulation of lipid storage (GO:0010888)2.67910017
134regulation of type I interferon-mediated signaling pathway (GO:0060338)2.67535686
135regulation of endothelial cell differentiation (GO:0045601)2.67412732
136positive regulation of antigen processing and presentation (GO:0002579)2.67032208
137viral transcription (GO:0019083)2.66473600
138positive regulation of cartilage development (GO:0061036)2.65937744
139regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.65056733
140positive regulation of response to biotic stimulus (GO:0002833)2.64858011
141positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.64487094
142response to interferon-gamma (GO:0034341)2.63273063
143response to host (GO:0075136)2.63152055
144response to host defenses (GO:0052200)2.63152055
145response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.63152055
146regulation of apoptotic process involved in morphogenesis (GO:1902337)2.63127963
147positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)2.62715049
148defense response to virus (GO:0051607)2.62536886
149ribosomal small subunit assembly (GO:0000028)2.61871188
150definitive hemopoiesis (GO:0060216)2.61675983
151wound healing, spreading of epidermal cells (GO:0035313)2.61450030
152mesodermal cell differentiation (GO:0048333)2.61019968
153positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.60852799
154monocyte chemotaxis (GO:0002548)2.60504569
155cellular response to interferon-gamma (GO:0071346)2.60035638
156translational termination (GO:0006415)2.59008127
157renal filtration (GO:0097205)2.58267111
158establishment of protein localization to endoplasmic reticulum (GO:0072599)2.58192394
159substrate adhesion-dependent cell spreading (GO:0034446)2.57757784
160protein localization to endoplasmic reticulum (GO:0070972)2.55441546
161type B pancreatic cell proliferation (GO:0044342)2.54681341
162angiogenesis (GO:0001525)2.53139965
163positive regulation of urine volume (GO:0035810)2.51966462
164lung vasculature development (GO:0060426)2.51088050
165branching involved in salivary gland morphogenesis (GO:0060445)2.49565689
166regulation of interleukin-8 secretion (GO:2000482)2.49442883
167regulation of mitochondrial translation (GO:0070129)2.49157404
168negative regulation of blood vessel endothelial cell migration (GO:0043537)2.46306866
169lymph vessel development (GO:0001945)2.46050441
170mesenchymal-epithelial cell signaling (GO:0060638)2.45056442
171positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.43246321
172positive regulation of odontogenesis (GO:0042482)2.39727735
173mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.36819835
174GTP biosynthetic process (GO:0006183)2.36461536
175negative regulation of DNA biosynthetic process (GO:2000279)2.34978965
176ribonucleoprotein complex biogenesis (GO:0022613)2.34889365
177positive regulation of interleukin-8 secretion (GO:2000484)2.34554913
178endothelial cell migration (GO:0043542)2.34285008
179cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.34081185
180translation (GO:0006412)2.34037822
181inositol phosphate-mediated signaling (GO:0048016)2.33832609
182positive regulation of endothelial cell migration (GO:0010595)2.33326125
183protein deneddylation (GO:0000338)2.33076457
184translational elongation (GO:0006414)2.31433339
185UTP biosynthetic process (GO:0006228)2.31367364
186regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.31265857
187chaperone-mediated protein transport (GO:0072321)2.30837618
188rRNA methylation (GO:0031167)2.30131606
189negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.30119377
190negative regulation of adherens junction organization (GO:1903392)2.30072448
191negative regulation of focal adhesion assembly (GO:0051895)2.30072448
192negative regulation of cell junction assembly (GO:1901889)2.30072448
193nucleobase-containing small molecule interconversion (GO:0015949)2.28302801
194cullin deneddylation (GO:0010388)2.27034809
195blood vessel endothelial cell migration (GO:0043534)2.25922609
196response to testosterone (GO:0033574)2.25673262

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.51526145
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.59475812
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.34662746
4IRF8_21731497_ChIP-ChIP_J774_Mouse5.17064495
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.64150199
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.01664150
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.44310747
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.36706801
9RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.31506007
10IRF8_27001747_Chip-Seq_BMDM_Mouse3.26968314
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.15859137
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.12295444
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.05005224
14MYC_18555785_ChIP-Seq_MESCs_Mouse3.02940409
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.00788705
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.99336093
17SCL_19346495_ChIP-Seq_HPC-7_Human2.92395351
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.78816558
19* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.74374318
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.68391933
21MYB_21317192_ChIP-Seq_ERMYB_Mouse2.64280602
22EGR1_19374776_ChIP-ChIP_THP-1_Human2.63095301
23PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.62175398
24GATA2_21666600_ChIP-Seq_HMVEC_Human2.55617165
25STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.43524555
26STAT4_19710469_ChIP-ChIP_TH1__Mouse2.39552233
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.39169611
28ETS1_20019798_ChIP-Seq_JURKAT_Human2.38845262
29NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.35970007
30EST1_17652178_ChIP-ChIP_JURKAT_Human2.34223428
31SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.28131373
32ZNF263_19887448_ChIP-Seq_K562_Human2.22572207
33E2F1_18555785_ChIP-Seq_MESCs_Mouse2.10593278
34NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.08440590
35MYC_18358816_ChIP-ChIP_MESCs_Mouse2.06480668
36PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.98254723
37DCP1A_22483619_ChIP-Seq_HELA_Human1.95741501
38RARG_19884340_ChIP-ChIP_MEFs_Mouse1.93467685
39ELK1_19687146_ChIP-ChIP_HELA_Human1.92662764
40EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.92097908
41STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.91572909
42* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.91564705
43TRIM28_21343339_ChIP-Seq_HEK293_Human1.91066225
44ELK1_22589737_ChIP-Seq_MCF10A_Human1.90827921
45CREB1_15753290_ChIP-ChIP_HEK293T_Human1.89684096
46HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.88757073
47TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.84008779
48MYC_19030024_ChIP-ChIP_MESCs_Mouse1.82148911
49NELFA_20434984_ChIP-Seq_ESCs_Mouse1.75637491
50GATA1_22025678_ChIP-Seq_K562_Human1.74995776
51* SPI1_23547873_ChIP-Seq_NB4_Human1.73203587
52CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.73088682
53MYC_19079543_ChIP-ChIP_MESCs_Mouse1.72914120
54STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.72536405
55ELK3_25401928_ChIP-Seq_HUVEC_Human1.70114496
56SRF_21415370_ChIP-Seq_HL-1_Mouse1.65616270
57MAF_26560356_Chip-Seq_TH1_Human1.61779044
58BRD4_27068464_Chip-Seq_AML-cells_Mouse1.61689375
59SMAD_19615063_ChIP-ChIP_OVARY_Human1.61315104
60BRD4_25478319_ChIP-Seq_HGPS_Human1.61277347
61VDR_24763502_ChIP-Seq_THP-1_Human1.60278569
62PPAR_26484153_Chip-Seq_NCI-H1993_Human1.53625890
63CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.53174790
64HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.50565521
65TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.48610567
66MYB_26560356_Chip-Seq_TH2_Human1.48407217
67RUNX_20019798_ChIP-Seq_JUKART_Human1.48011077
68CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.45549841
69NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.44577153
70PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.42355487
71POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.41297339
72* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.41056908
73PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.40400105
74VDR_24787735_ChIP-Seq_THP-1_Human1.40299852
75RUNX1_22412390_ChIP-Seq_EML_Mouse1.39227526
76SOX17_20123909_ChIP-Seq_XEN_Mouse1.38460081
77NANOG_18555785_ChIP-Seq_MESCs_Mouse1.38457377
78THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.37674293
79TTF2_22483619_ChIP-Seq_HELA_Human1.36579842
80STAT6_21828071_ChIP-Seq_BEAS2B_Human1.36470076
81XRN2_22483619_ChIP-Seq_HELA_Human1.36113247
82HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.35905337
83PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.34841773
84FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.33543915
85PU_27001747_Chip-Seq_BMDM_Mouse1.32751284
86ATF3_27146783_Chip-Seq_COLON_Human1.32604435
87CTCF_18555785_ChIP-Seq_MESCs_Mouse1.31891763
88* SOX2_20726797_ChIP-Seq_SW620_Human1.29153300
89CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29118357
90VDR_21846776_ChIP-Seq_THP-1_Human1.28368216
91SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.27931232
92THAP11_20581084_ChIP-Seq_MESCs_Mouse1.27799283
93SPI1_23127762_ChIP-Seq_K562_Human1.27574298
94HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.25706208
95SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.25137817
96SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.25137817
97EGR1_19032775_ChIP-ChIP_M12_Human1.24916939
98FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.24764182
99CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24503916
100* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.24441616
101ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.23465428
102PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.23101453
103GABP_19822575_ChIP-Seq_HepG2_Human1.22274520
104* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.20947535
105MYB_26560356_Chip-Seq_TH1_Human1.20371994
106MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.20093855
107TCF7_22412390_ChIP-Seq_EML_Mouse1.18704865
108UBF1/2_26484160_Chip-Seq_HMECs_Human1.17377404
109FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.17318942
110EOMES_21245162_ChIP-Seq_HESCs_Human1.16616738
111EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.16533643
112SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.15548086
113SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.14419428
114GATA2_22383799_ChIP-Seq_G1ME_Mouse1.14398310
115ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.11335548
116ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.09906272
117CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09137804
118RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.07590022
119TP53_22127205_ChIP-Seq_IMR90_Human1.07563418
120MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.06984005
121CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.05178124
122CJUN_26792858_Chip-Seq_BT549_Human1.04889973
123ESR1_21235772_ChIP-Seq_MCF-7_Human1.02911912
124SOX2_18692474_ChIP-Seq_MEFs_Mouse1.02346921
125KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02157338
126CDX2_20551321_ChIP-Seq_CACO-2_Human1.01994339
127NANOG_18692474_ChIP-Seq_MEFs_Mouse1.01842336
128TBX5_21415370_ChIP-Seq_HL-1_Mouse1.01421533
129UTX_26944678_Chip-Seq_JUKART_Human1.00025922
130TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.98678566
131SMC3_22415368_ChIP-Seq_MEFs_Mouse0.98407923
132NOTCH1_21737748_ChIP-Seq_TLL_Human0.98152248
133DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.97175632
134KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.96905114
135UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.96847450
136HIF1A_21447827_ChIP-Seq_MCF-7_Human0.96358053
137FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.95459804
138CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94551336
139NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.94206225
140E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.94145072
141KDM2B_26808549_Chip-Seq_SUP-B15_Human0.93708665
142* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.93039491
143SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.92982806
144KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.92905603
145GATA1_19941826_ChIP-Seq_K562_Human0.91411123
146JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91388629
147CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.91207333
148AR_21909140_ChIP-Seq_LNCAP_Human0.90945334
149PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90521189
150PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90175047
151NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.89090735
152MAF_26560356_Chip-Seq_TH2_Human0.89066030
153CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.88892577
154GATA3_27048872_Chip-Seq_THYMUS_Human0.88003875
155NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.87994341
156FOXP3_21729870_ChIP-Seq_TREG_Human0.87604502
157KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.87462295
158TP53_18474530_ChIP-ChIP_U2OS_Human0.87377980
159CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87276968
160CSB_26484114_Chip-Seq_FIBROBLAST_Human0.86749349
161SA1_22415368_ChIP-Seq_MEFs_Mouse0.85837304
162SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85624448
163VDR_23849224_ChIP-Seq_CD4+_Human0.85564235
164TCF3_18692474_ChIP-Seq_MEFs_Mouse0.84625297
165SOX2_18555785_ChIP-Seq_MESCs_Mouse0.84480468
166STAT3_1855785_ChIP-Seq_MESCs_Mouse0.83649544
167GATA1_22383799_ChIP-Seq_G1ME_Mouse0.83449094
168NCOR1_26117541_ChIP-Seq_K562_Human0.82575417
169ESR2_21235772_ChIP-Seq_MCF-7_Human0.82539409
170NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.82490795
171NRF2_20460467_ChIP-Seq_MEFs_Mouse0.82490795
172SALL4_18804426_ChIP-ChIP_XEN_Mouse0.82133688
173JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81369345
174GATA3_26560356_Chip-Seq_TH2_Human0.80353902

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.12513216
2MP0009785_altered_susceptibility_to3.95410507
3MP0001835_abnormal_antigen_presentation3.58391049
4MP0010030_abnormal_orbit_morphology3.47339666
5MP0003950_abnormal_plasma_membrane3.11814987
6MP0003436_decreased_susceptibility_to3.02850400
7MP0004510_myositis2.83207566
8MP0002148_abnormal_hypersensitivity_rea2.81846729
9MP0005025_abnormal_response_to2.63540061
10MP0005000_abnormal_immune_tolerance2.54387127
11MP0006054_spinal_hemorrhage2.52525970
12MP0002419_abnormal_innate_immunity2.51468679
13MP0000685_abnormal_immune_system2.48869884
14MP0003303_peritoneal_inflammation2.45120120
15MP0005671_abnormal_response_to2.44032555
16MP0005167_abnormal_blood-brain_barrier2.39957378
17MP0006082_CNS_inflammation2.39864878
18MP0009697_abnormal_copulation2.36129246
19MP0005623_abnormal_meninges_morphology2.29850682
20MP0003941_abnormal_skin_development2.25040495
21MP0002452_abnormal_antigen_presenting2.21751072
22MP0001879_abnormal_lymphatic_vessel2.15244828
23MP0005387_immune_system_phenotype2.10770015
24MP0001790_abnormal_immune_system2.10770015
25MP0002723_abnormal_immune_serum2.08139780
26MP0010368_abnormal_lymphatic_system2.07162450
27MP0001800_abnormal_humoral_immune2.02288886
28MP0005464_abnormal_platelet_physiology1.99838390
29MP0001533_abnormal_skeleton_physiology1.98339641
30MP0005595_abnormal_vascular_smooth1.92862527
31MP0004947_skin_inflammation1.92000028
32MP0000343_altered_response_to1.90878728
33MP0010155_abnormal_intestine_physiology1.90317195
34MP0001853_heart_inflammation1.88913806
35MP0009278_abnormal_bone_marrow1.87372736
36MP0009764_decreased_sensitivity_to1.85420472
37MP0001819_abnormal_immune_cell1.84639120
38MP0003448_altered_tumor_morphology1.84586159
39MP0002254_reproductive_system_inflammat1.82221051
40MP0009333_abnormal_splenocyte_physiolog1.80465729
41MP0000537_abnormal_urethra_morphology1.80119478
42MP0002420_abnormal_adaptive_immunity1.79298113
43MP0005503_abnormal_tendon_morphology1.78663156
44MP0003806_abnormal_nucleotide_metabolis1.76576387
45MP0003828_pulmonary_edema1.75458274
46MP0005397_hematopoietic_system_phenotyp1.74405199
47MP0001545_abnormal_hematopoietic_system1.74405199
48MP0004233_abnormal_muscle_weight1.66452890
49MP0009379_abnormal_foot_pigmentation1.65362407
50MP0003566_abnormal_cell_adhesion1.62875490
51MP0000858_altered_metastatic_potential1.62320855
52MP0001845_abnormal_inflammatory_respons1.61582145
53MP0005164_abnormal_response_to1.59607454
54MP0004808_abnormal_hematopoietic_stem1.58346169
55MP0000762_abnormal_tongue_morphology1.54501041
56MP0005084_abnormal_gallbladder_morpholo1.53539017
57MP0003075_altered_response_to1.52608586
58MP0002405_respiratory_system_inflammati1.51508386
59MP0002006_tumorigenesis1.51132700
60MP0000465_gastrointestinal_hemorrhage1.50158225
61MP0005197_abnormal_uvea_morphology1.45373744
62MP0003315_abnormal_perineum_morphology1.42877949
63MP0000049_abnormal_middle_ear1.40733879
64MP0009053_abnormal_anal_canal1.40002877
65MP0008469_abnormal_protein_level1.39458404
66MP0001849_ear_inflammation1.36860705
67MP0002933_joint_inflammation1.36270751
68MP0002998_abnormal_bone_remodeling1.34536057
69MP0010352_gastrointestinal_tract_polyps1.34328410
70MP0009840_abnormal_foam_cell1.32604156
71MP0000716_abnormal_immune_system1.28430002
72MP0003186_abnormal_redox_activity1.27014652
73MP0001851_eye_inflammation1.25612252
74* MP0002398_abnormal_bone_marrow1.25073577
75MP0000013_abnormal_adipose_tissue1.24588572
76MP0002166_altered_tumor_susceptibility1.24564740
77MP0000767_abnormal_smooth_muscle1.24208746
78MP0005360_urolithiasis1.24087146
79MP0000249_abnormal_blood_vessel1.24001984
80MP0005390_skeleton_phenotype1.23967624
81MP0003011_delayed_dark_adaptation1.21124328
82MP0005023_abnormal_wound_healing1.20819398
83MP0005058_abnormal_lysosome_morphology1.19958702
84MP0005166_decreased_susceptibility_to1.18833421
85MP0003091_abnormal_cell_migration1.17343281
86MP0003718_maternal_effect1.16402017
87MP0003786_premature_aging1.15696202
88MP0002877_abnormal_melanocyte_morpholog1.13312868
89MP0004272_abnormal_basement_membrane1.11529457
90MP0000689_abnormal_spleen_morphology1.08621144
91MP0005275_abnormal_skin_tensile1.08463878
92MP0003300_gastrointestinal_ulcer1.07878895
93MP0000750_abnormal_muscle_regeneration1.07752682
94* MP0002429_abnormal_blood_cell1.07102301
95MP0009780_abnormal_chondrocyte_physiolo1.06705653
96MP0008932_abnormal_embryonic_tissue1.04852741
97MP0002722_abnormal_immune_system1.04693593
98MP0009250_abnormal_appendicular_skeleto1.04174949
99MP0005508_abnormal_skeleton_morphology1.02659140
100MP0003385_abnormal_body_wall1.00127878
101MP0002234_abnormal_pharynx_morphology0.96990079
102MP0003453_abnormal_keratinocyte_physiol0.96294124
103MP0008438_abnormal_cutaneous_collagen0.95989321
104MP0003045_fibrosis0.94984561
105MP0002138_abnormal_hepatobiliary_system0.94208627
106MP0003191_abnormal_cellular_cholesterol0.94006330
107MP0008775_abnormal_heart_ventricle0.93598194
108MP0002925_abnormal_cardiovascular_devel0.93433314
109MP0000467_abnormal_esophagus_morphology0.93308928
110MP0005501_abnormal_skin_physiology0.92796099
111MP0001958_emphysema0.92632768
112MP0002060_abnormal_skin_morphology0.91239155
113MP0000490_abnormal_crypts_of0.89163736
114MP0002932_abnormal_joint_morphology0.88790371
115MP0004883_abnormal_blood_vessel0.88540987
116MP0000163_abnormal_cartilage_morphology0.87878090
117MP0010234_abnormal_vibrissa_follicle0.86217067
118MP0005310_abnormal_salivary_gland0.86040664
119MP0002896_abnormal_bone_mineralization0.86029389
120MP0001661_extended_life_span0.85490922
121MP0002332_abnormal_exercise_endurance0.85037727
122MP0001915_intracranial_hemorrhage0.84074491
123MP0006138_congestive_heart_failure0.83512273
124MP0008004_abnormal_stomach_pH0.82908741
125MP0000647_abnormal_sebaceous_gland0.82898489
126MP0003755_abnormal_palate_morphology0.80639766
127MP0003279_aneurysm0.80575460
128MP0003705_abnormal_hypodermis_morpholog0.80082453
129MP0002177_abnormal_outer_ear0.79680547
130MP0001542_abnormal_bone_strength0.77367813
131MP0003935_abnormal_craniofacial_develop0.77098224
132MP0000613_abnormal_salivary_gland0.76115286
133MP0009763_increased_sensitivity_to0.74740250
134MP0005165_increased_susceptibility_to0.74088000
135MP0001881_abnormal_mammary_gland0.73539146
136MP0005330_cardiomyopathy0.72848845
137MP0003943_abnormal_hepatobiliary_system0.71634673
138MP0008007_abnormal_cellular_replicative0.71409019
139MP0004133_heterotaxia0.71122539
140MP0006072_abnormal_retinal_apoptosis0.71020894
141MP0000538_abnormal_urinary_bladder0.70647222
142MP0002127_abnormal_cardiovascular_syste0.70371482
143MP0004957_abnormal_blastocyst_morpholog0.70139500
144MP0005395_other_phenotype0.69679383
145MP0002796_impaired_skin_barrier0.69628235
146MP0004084_abnormal_cardiac_muscle0.69164344
147MP0000678_abnormal_parathyroid_gland0.68984808
148* MP0003984_embryonic_growth_retardation0.68838206
149MP0002295_abnormal_pulmonary_circulatio0.67433869
150MP0001348_abnormal_lacrimal_gland0.67196104
151MP0000358_abnormal_cell_content/0.66768607
152MP0003866_abnormal_defecation0.66503960
153MP0001614_abnormal_blood_vessel0.66140419
154MP0003221_abnormal_cardiomyocyte_apopto0.66019780
155MP0005408_hypopigmentation0.65652143
156MP0004782_abnormal_surfactant_physiolog0.65136069
157MP0000733_abnormal_muscle_development0.64821494
158* MP0002088_abnormal_embryonic_growth/wei0.64794536
159MP0010771_integument_phenotype0.64598891
160MP0003795_abnormal_bone_structure0.63805834
161MP0002972_abnormal_cardiac_muscle0.63623713
162MP0002160_abnormal_reproductive_system0.63353888
163MP0002128_abnormal_blood_circulation0.63293560
164MP0002697_abnormal_eye_size0.63032434
165MP0005257_abnormal_intraocular_pressure0.62836116
166MP0005193_abnormal_anterior_eye0.61714370
167MP0004858_abnormal_nervous_system0.59382777

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.08122446
2Eczematoid dermatitis (HP:0000976)4.96092308
3Myositis (HP:0100614)4.89354759
4Recurrent bacterial skin infections (HP:0005406)4.86336790
5Elevated erythrocyte sedimentation rate (HP:0003565)4.79065335
6Premature rupture of membranes (HP:0001788)4.60409916
7Autoimmune thrombocytopenia (HP:0001973)4.37679353
8Interstitial pulmonary disease (HP:0006530)4.35848471
9Orchitis (HP:0100796)4.27249614
10Abnormality of macrophages (HP:0004311)4.08454901
11Recurrent gram-negative bacterial infections (HP:0005420)3.67076525
12Optic neuritis (HP:0100653)3.55601461
13Retrobulbar optic neuritis (HP:0100654)3.55601461
14Thrombocytosis (HP:0001894)3.54678546
15Chronic otitis media (HP:0000389)3.43255464
16Abnormality of the nasal mucosa (HP:0000433)3.39032402
17Stenosis of the external auditory canal (HP:0000402)3.31233839
18Increased cerebral lipofuscin (HP:0011813)3.27403153
19Increased neuronal autofluorescent lipopigment (HP:0002074)3.26836093
20Tetraparesis (HP:0002273)3.25581177
21Mediastinal lymphadenopathy (HP:0100721)3.25083550
22Vertebral compression fractures (HP:0002953)3.22025111
23Trismus (HP:0000211)3.16815033
24Vacuolated lymphocytes (HP:0001922)3.13466537
25Wrist flexion contracture (HP:0001239)3.09067397
26Cellulitis (HP:0100658)3.08161608
27Petechiae (HP:0000967)3.02154737
28Acute necrotizing encephalopathy (HP:0006965)3.01392278
29Radial bowing (HP:0002986)3.01061533
30Vasculitis (HP:0002633)3.00070317
31Deformed tarsal bones (HP:0008119)2.99339177
32Recurrent skin infections (HP:0001581)2.98474324
33Reduced subcutaneous adipose tissue (HP:0003758)2.96614128
34Hypoplasia of the uterus (HP:0000013)2.92346502
35Hematochezia (HP:0002573)2.92346165
36Nonimmune hydrops fetalis (HP:0001790)2.90540267
37Congenital, generalized hypertrichosis (HP:0004540)2.85913786
38Recurrent fungal infections (HP:0002841)2.84704764
39Purpura (HP:0000979)2.84388258
40Atrophic scars (HP:0001075)2.83635493
41Arterial thrombosis (HP:0004420)2.82937793
42Spontaneous hematomas (HP:0007420)2.77012646
43Abnormal mitochondria in muscle tissue (HP:0008316)2.74550558
44Pustule (HP:0200039)2.66334838
45Arterial tortuosity (HP:0005116)2.65354811
46Stomatitis (HP:0010280)2.65054874
47Recurrent viral infections (HP:0004429)2.64810413
48Mitochondrial inheritance (HP:0001427)2.63207450
49Cerebral hemorrhage (HP:0001342)2.63082880
50Spinal rigidity (HP:0003306)2.62892157
51Acute encephalopathy (HP:0006846)2.61201810
52Hypergammaglobulinemia (HP:0010702)2.61024290
53Gingivitis (HP:0000230)2.57954803
54Fragile nails (HP:0001808)2.56886122
55Nasal polyposis (HP:0100582)2.54373389
56Prolonged bleeding time (HP:0003010)2.52997762
57Gingival bleeding (HP:0000225)2.52934820
58Increased IgE level (HP:0003212)2.49086836
59Type I transferrin isoform profile (HP:0003642)2.47729680
60Increased IgM level (HP:0003496)2.47517663
61Autoimmune hemolytic anemia (HP:0001890)2.45739912
62Onycholysis (HP:0001806)2.44690541
63Menorrhagia (HP:0000132)2.43222385
64Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.42576393
65Aplasia/hypoplasia of the uterus (HP:0008684)2.42498158
66Short nail (HP:0001799)2.41628185
67Reticulocytopenia (HP:0001896)2.40617574
68Micronodular cirrhosis (HP:0001413)2.39546644
69Epistaxis (HP:0000421)2.39216234
70Increased CSF lactate (HP:0002490)2.39165068
71Chronic obstructive pulmonary disease (HP:0006510)2.36004856
72Obstructive lung disease (HP:0006536)2.36004856
73Chest pain (HP:0100749)2.35989681
74Porencephaly (HP:0002132)2.35185919
75Esophageal varix (HP:0002040)2.31856590
76Selective tooth agenesis (HP:0001592)2.31738089
77Subacute progressive viral hepatitis (HP:0006572)2.30857690
78Hemoptysis (HP:0002105)2.29732235
79Basal ganglia calcification (HP:0002135)2.28540419
80Follicular hyperkeratosis (HP:0007502)2.27957256
81Abnormal number of erythroid precursors (HP:0012131)2.26215552
82Impaired platelet aggregation (HP:0003540)2.23589460
83Abnormal platelet function (HP:0011869)2.23589460
84Progressive macrocephaly (HP:0004481)2.23407355
85Abnormality of cells of the erythroid lineage (HP:0012130)2.22143995
86Cardiovascular calcification (HP:0011915)2.21338729
87Peritonitis (HP:0002586)2.20405134
88Protrusio acetabuli (HP:0003179)2.20024933
89Bowed forearm bones (HP:0003956)2.19711777
90Bowing of the arm (HP:0006488)2.19711777
91Pulmonary infiltrates (HP:0002113)2.19110428
92Abnormality of the pericardium (HP:0001697)2.18988047
93Keratoconjunctivitis sicca (HP:0001097)2.18751553
94Myocardial infarction (HP:0001658)2.17747478
95Prostate neoplasm (HP:0100787)2.17304622
96Polycythemia (HP:0001901)2.17093943
97Axonal loss (HP:0003447)2.16346932
98Periodontitis (HP:0000704)2.16027010
99Aortic valve stenosis (HP:0001650)2.15616421
100Thick nail (HP:0001805)2.15419223
101Calcaneovalgus deformity (HP:0001848)2.14082505
102Mesomelia (HP:0003027)2.13625099
103Ankle contracture (HP:0006466)2.13080351
104Poor head control (HP:0002421)2.12666477
105Sensory axonal neuropathy (HP:0003390)2.12382550
106Abnormality of the fetal cardiovascular system (HP:0010948)2.12028506
107Abnormal umbilical cord blood vessels (HP:0011403)2.12028506
108Single umbilical artery (HP:0001195)2.12028506
109Increased hepatocellular lipid droplets (HP:0006565)2.11765091
110Fragile skin (HP:0001030)2.11307035
111Rough bone trabeculation (HP:0100670)2.11032044
112Hepatocellular necrosis (HP:0001404)2.09860289
113Occipital encephalocele (HP:0002085)2.09761831
114Sparse eyelashes (HP:0000653)2.09586744
115Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.09367357
116Abnormal protein N-linked glycosylation (HP:0012347)2.09367357
117Abnormal protein glycosylation (HP:0012346)2.09367357
118Abnormal glycosylation (HP:0012345)2.09367357
119Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.09349226
120Decreased activity of mitochondrial respiratory chain (HP:0008972)2.09349226
121Wormian bones (HP:0002645)2.08684054
122Increased serum ferritin (HP:0003281)2.07928939
123Ulnar deviation of the wrist (HP:0003049)2.07626674
124Soft skin (HP:0000977)2.07518772
125Amaurosis fugax (HP:0100576)2.05904389
126Renal Fanconi syndrome (HP:0001994)2.05827641
127Osteolytic defects of the hand bones (HP:0009699)2.05382235
128Osteolytic defects of the phalanges of the hand (HP:0009771)2.05382235
129Fatigue (HP:0012378)2.03805421
130Vascular calcification (HP:0004934)2.02127057
131Leukocytosis (HP:0001974)2.00600480
132Beaking of vertebral bodies (HP:0004568)1.99446127
133Aortic dissection (HP:0002647)1.98460006
134Entropion (HP:0000621)1.98217702
135Emphysema (HP:0002097)1.98135034
136Conjunctival telangiectasia (HP:0000524)1.97602582
137Keratoconjunctivitis (HP:0001096)1.96102240
138Bruising susceptibility (HP:0000978)1.95974529
139Abnormality of dentin (HP:0010299)1.94728936
140Abnormality of liposaccharide metabolism (HP:0010968)1.92527107
141Abnormality of glycosphingolipid metabolism (HP:0004343)1.92527107
142Abnormality of glycolipid metabolism (HP:0010969)1.92527107
143Gastrointestinal infarctions (HP:0005244)1.92335069
144Cervical subluxation (HP:0003308)1.92324197
145Abnormality of the umbilical cord (HP:0010881)1.90831748
146Abnormality of the distal phalanges of the toes (HP:0010182)1.90299381
147Osteomyelitis (HP:0002754)1.88686234
148Urticaria (HP:0001025)1.88075596
149Skull defect (HP:0001362)1.86920665
150Neoplasm of head and neck (HP:0012288)1.86902923
151Esophageal neoplasm (HP:0100751)1.86902923
152Shallow orbits (HP:0000586)1.86844904
153Facial diplegia (HP:0001349)1.86769814
154Viral hepatitis (HP:0006562)1.85346631
155Aortic aneurysm (HP:0004942)1.83863274
156Systemic lupus erythematosus (HP:0002725)1.83684658
157Meningitis (HP:0001287)1.83653107
158Lipid accumulation in hepatocytes (HP:0006561)1.82864505
159Hypokinesia (HP:0002375)1.82491890
160Redundant skin (HP:0001582)1.82101430
161Adactyly (HP:0009776)1.81178648
162Abnormal platelet volume (HP:0011876)1.79975328
163Bladder diverticulum (HP:0000015)1.79701353
164Macrocytic anemia (HP:0001972)1.79070089
165Bifid uvula (HP:0000193)1.78976684
166Premature loss of primary teeth (HP:0006323)1.77926283
167Arthralgia (HP:0002829)1.77260774
168Vascular tortuosity (HP:0004948)1.76381246
169Delayed gross motor development (HP:0002194)1.75880706
170Testicular atrophy (HP:0000029)1.75213284
171Joint stiffness (HP:0001387)1.75076454
172Colitis (HP:0002583)1.74930886
173Exertional dyspnea (HP:0002875)1.73726784
174Fibular aplasia (HP:0002990)1.73254863
175Hepatic necrosis (HP:0002605)1.72752746
176Gangrene (HP:0100758)1.70945096
177Glucose intolerance (HP:0000833)1.70064600
178Blue sclerae (HP:0000592)1.69943474
179Coxa vara (HP:0002812)1.69826210
180Aplasia cutis congenita (HP:0001057)1.69690275
181Aplasia/Hypoplasia of the clavicles (HP:0006710)1.69398333
182Abnormalities of placenta or umbilical cord (HP:0001194)1.68307810
183Abnormal trabecular bone morphology (HP:0100671)1.67773502
184Cerebral edema (HP:0002181)1.67265879
185Portal hypertension (HP:0001409)1.67043806
186Plantar hyperkeratosis (HP:0007556)1.65843484
187Spinal cord compression (HP:0002176)1.65370804
188Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.64623462

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE14.09035478
2TBK13.88137023
3MAP3K143.52673141
4JAK33.26936630
5PBK3.05505122
6PIM22.98590499
7IKBKE2.72691264
8ERN12.55295367
9NME22.50037232
10BUB12.40411105
11TGFBR12.36588069
12TGFBR22.28755426
13IKBKB2.25394040
14TYK22.23702471
15KIT2.22349650
16KDR2.16015252
17PTK21.99888961
18RIPK41.93651053
19PDK21.87315662
20IRAK41.78892498
21VRK21.77607120
22LIMK11.70455375
23RIPK11.68433282
24EPHB11.59567868
25IRAK31.57471829
26CHUK1.56419367
27MUSK1.55702093
28MATK1.53508755
29BTK1.43372540
30MST1R1.38981604
31JAK11.37975885
32FGFR41.37194998
33MYLK1.35914365
34EPHA21.34549669
35NTRK11.34190216
36STK161.33296910
37TEC1.33030686
38TLK11.28392820
39BLK1.26235764
40BMX1.23561725
41PTK61.23022283
42MAP2K31.21565905
43LMTK21.20376377
44EPHA31.20013549
45ZAK1.17906064
46CDK81.17460514
47ZAP701.15490562
48TAF11.15014092
49MAP4K11.13961336
50CSK1.12852940
51MST41.08527145
52SYK1.04719199
53HCK1.04555650
54TSSK61.04141452
55PKN21.02804824
56PIM11.00265281
57MAP3K130.98124177
58INSRR0.97370826
59LRRK20.96559063
60TXK0.93246211
61LCK0.90827347
62GRK10.90698601
63RPS6KA40.90495737
64CSF1R0.90150329
65TESK10.89960364
66ABL20.88904875
67PRKG20.88052624
68PRKCI0.87579730
69FER0.87508621
70FES0.85109349
71MAP3K30.83083076
72LYN0.83080147
73NME10.82409995
74PDGFRA0.82408950
75PLK40.81691767
76FLT30.81056647
77ARAF0.80656028
78EIF2AK10.80589648
79FGFR30.79478774
80FGR0.77820976
81MARK30.76676214
82NEK10.74812786
83EIF2AK30.74664137
84NLK0.74527957
85PAK40.73478084
86ILK0.72209352
87STK38L0.70280442
88NEK90.67812737
89JAK20.66414954
90ABL10.65448079
91LATS20.64641958
92TRIM280.64200555
93BMPR1B0.63946345
94MAPKAPK30.61833154
95TTK0.61575099
96EGFR0.61565041
97MOS0.61518195
98CAMKK20.61385587
99ERBB40.61197470
100ADRBK10.60664665
101BRSK20.57684010
102TRIB30.57652169
103TRPM70.56423109
104CAMK1D0.55775444
105ADRBK20.55579020
106PAK20.54895223
107PRKCD0.54448231
108STK100.54227380
109EIF2AK20.53223656
110MAPKAPK50.53152298
111SIK30.51889014
112DAPK30.51067294
113PLK30.50631026
114MET0.50406200
115CDK60.49992494
116TAOK30.48928212
117AURKA0.48722957
118MAP3K10.48081016
119VRK10.47129514
120WEE10.47086642
121DDR20.46788611
122TTN0.46705220
123PRKCE0.46455279
124MAPK40.46450547
125MAPKAPK20.43659166
126PDK10.42569982
127ROCK20.42422299
128PINK10.41989022
129SRPK10.41511608
130RET0.39784171
131MAP3K50.38979405
132ROCK10.38909675
133MAP3K120.38511341
134PLK10.38498812
135AURKB0.37610918
136PDPK10.37206336
137PIK3CG0.35991922
138CHEK20.34425840
139EPHB20.34273841
140STK40.33333082
141PTK2B0.33138767
142IRAK10.33134806
143PNCK0.32966330
144MAP3K110.32828177
145RPS6KA60.32552618
146NEK20.32479990
147STK390.31898754
148WNK40.31608511
149IGF1R0.31498920
150BRSK10.31379786
151TNIK0.30811572
152MAP2K20.30634738
153MAPK120.30509047
154STK240.30143119
155MAP3K80.29849278
156ERBB30.29614913
157PRKD30.29294796
158STK30.28622610
159CSNK1G10.27042883
160CSNK1G30.26292884
161PAK10.25866051
162PDGFRB0.25545191
163CAMK1G0.23786660
164GSK3A0.23553959
165AKT20.23353563

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.16470043
2RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.88152476
3Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.85338051
4Oxidative phosphorylation_Homo sapiens_hsa001902.83368240
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.77094341
6Malaria_Homo sapiens_hsa051442.69563782
7Sulfur metabolism_Homo sapiens_hsa009202.49764771
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.47246126
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.45054541
10Legionellosis_Homo sapiens_hsa051342.41934322
11Graft-versus-host disease_Homo sapiens_hsa053322.34155857
12Allograft rejection_Homo sapiens_hsa053302.32441540
13Protein export_Homo sapiens_hsa030602.29233171
14Parkinsons disease_Homo sapiens_hsa050122.25712959
15RNA polymerase_Homo sapiens_hsa030202.24436891
16Pertussis_Homo sapiens_hsa051332.21782021
17NOD-like receptor signaling pathway_Homo sapiens_hsa046212.18546105
18Measles_Homo sapiens_hsa051622.18161257
19TNF signaling pathway_Homo sapiens_hsa046682.17084153
20Osteoclast differentiation_Homo sapiens_hsa043802.10690641
21Glutathione metabolism_Homo sapiens_hsa004802.06103271
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.05758311
23Rheumatoid arthritis_Homo sapiens_hsa053231.97035057
24Influenza A_Homo sapiens_hsa051641.85707636
25Salmonella infection_Homo sapiens_hsa051321.84471351
26Staphylococcus aureus infection_Homo sapiens_hsa051501.79281618
27Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.77913816
28Huntingtons disease_Homo sapiens_hsa050161.76469598
29Pyrimidine metabolism_Homo sapiens_hsa002401.75981365
30Alzheimers disease_Homo sapiens_hsa050101.74280044
31African trypanosomiasis_Homo sapiens_hsa051431.74225794
32Hematopoietic cell lineage_Homo sapiens_hsa046401.74095423
33Jak-STAT signaling pathway_Homo sapiens_hsa046301.70735443
34Sulfur relay system_Homo sapiens_hsa041221.69422953
35Tuberculosis_Homo sapiens_hsa051521.63605090
36Herpes simplex infection_Homo sapiens_hsa051681.63377626
37Selenocompound metabolism_Homo sapiens_hsa004501.62538432
38Toxoplasmosis_Homo sapiens_hsa051451.61514362
39Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.61000945
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.56301173
41N-Glycan biosynthesis_Homo sapiens_hsa005101.54426850
42Shigellosis_Homo sapiens_hsa051311.53900338
43Type I diabetes mellitus_Homo sapiens_hsa049401.51062518
44Intestinal immune network for IgA production_Homo sapiens_hsa046721.46635173
45B cell receptor signaling pathway_Homo sapiens_hsa046621.46625661
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.44902741
47Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.43379682
48Leukocyte transendothelial migration_Homo sapiens_hsa046701.41962162
49Basal cell carcinoma_Homo sapiens_hsa052171.40188682
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.39919404
51Apoptosis_Homo sapiens_hsa042101.39368809
52Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.37942664
53AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.37942167
54Phagosome_Homo sapiens_hsa041451.34646369
55Antigen processing and presentation_Homo sapiens_hsa046121.33691709
56Asthma_Homo sapiens_hsa053101.31600241
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.31551461
58Folate biosynthesis_Homo sapiens_hsa007901.28400577
59Hepatitis B_Homo sapiens_hsa051611.26804027
60Fructose and mannose metabolism_Homo sapiens_hsa000511.23884185
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.21582634
62Homologous recombination_Homo sapiens_hsa034401.19754737
63Amoebiasis_Homo sapiens_hsa051461.19511584
64Hepatitis C_Homo sapiens_hsa051601.13010020
65Hedgehog signaling pathway_Homo sapiens_hsa043401.12179031
66Cysteine and methionine metabolism_Homo sapiens_hsa002701.10588215
67Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.09544442
68Platelet activation_Homo sapiens_hsa046111.09302216
69One carbon pool by folate_Homo sapiens_hsa006701.07906585
70Viral myocarditis_Homo sapiens_hsa054161.07455479
71Chemokine signaling pathway_Homo sapiens_hsa040621.07200529
72Basal transcription factors_Homo sapiens_hsa030221.06276580
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.04577946
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.04284731
75Nucleotide excision repair_Homo sapiens_hsa034201.04032229
76Vitamin B6 metabolism_Homo sapiens_hsa007501.02400379
77DNA replication_Homo sapiens_hsa030301.00601138
78HIF-1 signaling pathway_Homo sapiens_hsa040661.00338994
79Lysosome_Homo sapiens_hsa041421.00091082
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.98628435
81Vibrio cholerae infection_Homo sapiens_hsa051100.96935149
82Primary immunodeficiency_Homo sapiens_hsa053400.94082843
83Acute myeloid leukemia_Homo sapiens_hsa052210.92957931
84Pentose phosphate pathway_Homo sapiens_hsa000300.92228745
85Purine metabolism_Homo sapiens_hsa002300.90473387
86Small cell lung cancer_Homo sapiens_hsa052220.89590737
87Sphingolipid metabolism_Homo sapiens_hsa006000.89275344
88ECM-receptor interaction_Homo sapiens_hsa045120.87790528
89Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.85766141
90Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.82958911
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.82548038
92Base excision repair_Homo sapiens_hsa034100.82367715
93Bladder cancer_Homo sapiens_hsa052190.82339521
94Autoimmune thyroid disease_Homo sapiens_hsa053200.81643834
95Hippo signaling pathway_Homo sapiens_hsa043900.81188908
96Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.81079678
97Other glycan degradation_Homo sapiens_hsa005110.80703530
98Glycosaminoglycan degradation_Homo sapiens_hsa005310.80122711
99Prolactin signaling pathway_Homo sapiens_hsa049170.80085626
100Metabolic pathways_Homo sapiens_hsa011000.79901411
101Fatty acid elongation_Homo sapiens_hsa000620.79834635
102Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79484720
103Proteoglycans in cancer_Homo sapiens_hsa052050.79002797
104Chronic myeloid leukemia_Homo sapiens_hsa052200.73390854
105RNA transport_Homo sapiens_hsa030130.73380992
106Focal adhesion_Homo sapiens_hsa045100.72011892
107Steroid biosynthesis_Homo sapiens_hsa001000.68556708
108Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67602608
109Vitamin digestion and absorption_Homo sapiens_hsa049770.67580711
110Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.65993543
111Pyruvate metabolism_Homo sapiens_hsa006200.65087533
112Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.62460278
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.62079576
114Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.61791401
115Nitrogen metabolism_Homo sapiens_hsa009100.61747416
116Arginine and proline metabolism_Homo sapiens_hsa003300.61039677
117Mismatch repair_Homo sapiens_hsa034300.60967431
118SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60393170
119Fanconi anemia pathway_Homo sapiens_hsa034600.60138469
120Epstein-Barr virus infection_Homo sapiens_hsa051690.58873894
121Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.58446005
122Tight junction_Homo sapiens_hsa045300.57382979
123p53 signaling pathway_Homo sapiens_hsa041150.56725210
124Proteasome_Homo sapiens_hsa030500.54130649
125Cardiac muscle contraction_Homo sapiens_hsa042600.53723562
126Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52048625
127Protein digestion and absorption_Homo sapiens_hsa049740.52029972
128Prion diseases_Homo sapiens_hsa050200.51727938
129Viral carcinogenesis_Homo sapiens_hsa052030.50827001
130Ribosome_Homo sapiens_hsa030100.50173596
131Neurotrophin signaling pathway_Homo sapiens_hsa047220.49268130
132Arachidonic acid metabolism_Homo sapiens_hsa005900.49092250
133HTLV-I infection_Homo sapiens_hsa051660.47156792
134PI3K-Akt signaling pathway_Homo sapiens_hsa041510.46850803
135Chemical carcinogenesis_Homo sapiens_hsa052040.46462548
136Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46329478
137Axon guidance_Homo sapiens_hsa043600.45067590
138Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44917847
139RNA degradation_Homo sapiens_hsa030180.44186829
140Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43994274
141Notch signaling pathway_Homo sapiens_hsa043300.43463020
142Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43441023
143Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42389713
144Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41257389
145Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41084610
146VEGF signaling pathway_Homo sapiens_hsa043700.40759574
147Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.39840722
148* Complement and coagulation cascades_Homo sapiens_hsa046100.39744419
149Galactose metabolism_Homo sapiens_hsa000520.38548476
150Adherens junction_Homo sapiens_hsa045200.38365108
151Pancreatic cancer_Homo sapiens_hsa052120.38356008
152Rap1 signaling pathway_Homo sapiens_hsa040150.38298594
153Renin-angiotensin system_Homo sapiens_hsa046140.37840807
154T cell receptor signaling pathway_Homo sapiens_hsa046600.37606095
155MicroRNAs in cancer_Homo sapiens_hsa052060.37384571
156Arginine biosynthesis_Homo sapiens_hsa002200.36283964
157Biosynthesis of amino acids_Homo sapiens_hsa012300.35689388
158Pathways in cancer_Homo sapiens_hsa052000.35404200
159TGF-beta signaling pathway_Homo sapiens_hsa043500.33599263
160Insulin resistance_Homo sapiens_hsa049310.33533595
161Carbon metabolism_Homo sapiens_hsa012000.32692895
162Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.32509688
163Caffeine metabolism_Homo sapiens_hsa002320.32302186
164Thyroid cancer_Homo sapiens_hsa052160.31371526
165Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.30661884
166Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.29532313
167Mineral absorption_Homo sapiens_hsa049780.27253069
168Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26289064

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