PRODH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a mitochondrial protein that catalyzes the first step in proline degradation. Mutations in this gene are associated with hyperprolinemia type 1 and susceptibility to schizophrenia 4 (SCZD4). This gene is located on chromosome 22q11.21, a region which has also been associated with the contiguous gene deletion syndromes, DiGeorge and CATCH22. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.25092504
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.25092504
3L-phenylalanine metabolic process (GO:0006558)7.01770360
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.01770360
5aromatic amino acid family catabolic process (GO:0009074)6.64382308
6tryptophan catabolic process (GO:0006569)6.14419535
7indole-containing compound catabolic process (GO:0042436)6.14419535
8indolalkylamine catabolic process (GO:0046218)6.14419535
9glyoxylate metabolic process (GO:0046487)5.89009421
10kynurenine metabolic process (GO:0070189)5.84831306
11triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.83890846
12tryptophan metabolic process (GO:0006568)5.77161131
13cysteine metabolic process (GO:0006534)5.65765451
14bile acid biosynthetic process (GO:0006699)5.60803881
15sulfur amino acid catabolic process (GO:0000098)5.51803726
16alpha-linolenic acid metabolic process (GO:0036109)5.47336343
17lysine metabolic process (GO:0006553)5.40632435
18lysine catabolic process (GO:0006554)5.40632435
19serine family amino acid catabolic process (GO:0009071)5.39457346
20urea cycle (GO:0000050)5.20352764
21urea metabolic process (GO:0019627)5.20352764
22homocysteine metabolic process (GO:0050667)5.14070547
23fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.08178429
24high-density lipoprotein particle remodeling (GO:0034375)5.03657197
25amino-acid betaine metabolic process (GO:0006577)4.90008495
26aromatic amino acid family metabolic process (GO:0009072)4.84124059
27nitrogen cycle metabolic process (GO:0071941)4.81037222
28* alpha-amino acid catabolic process (GO:1901606)4.76302253
29complement activation, alternative pathway (GO:0006957)4.75466873
30bile acid metabolic process (GO:0008206)4.74321304
31epoxygenase P450 pathway (GO:0019373)4.62927808
32negative regulation of fibrinolysis (GO:0051918)4.62917079
33regulation of protein activation cascade (GO:2000257)4.61949560
34peptidyl-glutamic acid carboxylation (GO:0017187)4.60575551
35protein carboxylation (GO:0018214)4.60575551
36reverse cholesterol transport (GO:0043691)4.55718816
37regulation of triglyceride catabolic process (GO:0010896)4.49028704
38* cellular amino acid catabolic process (GO:0009063)4.48064649
39serine family amino acid metabolic process (GO:0009069)4.47886089
40regulation of fibrinolysis (GO:0051917)4.47367229
41negative regulation of sterol transport (GO:0032372)4.45884871
42negative regulation of cholesterol transport (GO:0032375)4.45884871
43tyrosine metabolic process (GO:0006570)4.45056242
44protein-lipid complex remodeling (GO:0034368)4.43462658
45macromolecular complex remodeling (GO:0034367)4.43462658
46plasma lipoprotein particle remodeling (GO:0034369)4.43462658
47regulation of cholesterol esterification (GO:0010872)4.43159258
48cellular ketone body metabolic process (GO:0046950)4.41792439
49glycine metabolic process (GO:0006544)4.41612343
50short-chain fatty acid metabolic process (GO:0046459)4.40896767
51ethanol oxidation (GO:0006069)4.38756237
52* cellular modified amino acid catabolic process (GO:0042219)4.36012492
53drug transmembrane transport (GO:0006855)4.35123764
54drug catabolic process (GO:0042737)4.34986162
55regulation of complement activation (GO:0030449)4.33626329
56serine family amino acid biosynthetic process (GO:0009070)4.32924315
57cellular glucuronidation (GO:0052695)4.31395567
58indolalkylamine metabolic process (GO:0006586)4.31028663
59amine catabolic process (GO:0009310)4.30229781
60cellular biogenic amine catabolic process (GO:0042402)4.30229781
61coenzyme catabolic process (GO:0009109)4.25391929
62urate metabolic process (GO:0046415)4.22556489
63* glutamate metabolic process (GO:0006536)4.21357039
64low-density lipoprotein particle remodeling (GO:0034374)4.09824123
65triglyceride homeostasis (GO:0070328)4.09483281
66acylglycerol homeostasis (GO:0055090)4.09483281
67phospholipid efflux (GO:0033700)4.05949071
68dicarboxylic acid biosynthetic process (GO:0043650)4.05848719
69benzene-containing compound metabolic process (GO:0042537)4.02681758
70imidazole-containing compound metabolic process (GO:0052803)4.02467415
71regulation of guanylate cyclase activity (GO:0031282)4.02082476
72aspartate family amino acid catabolic process (GO:0009068)3.99833931
732-oxoglutarate metabolic process (GO:0006103)3.96874800
74exogenous drug catabolic process (GO:0042738)3.94954868
75bile acid and bile salt transport (GO:0015721)3.93663828
76acetyl-CoA metabolic process (GO:0006084)3.93573660
77* organic acid catabolic process (GO:0016054)3.93529094
78* carboxylic acid catabolic process (GO:0046395)3.93529094
79valine metabolic process (GO:0006573)3.87087913
80uronic acid metabolic process (GO:0006063)3.85507889
81glucuronate metabolic process (GO:0019585)3.85507889
82arginine metabolic process (GO:0006525)3.83309312
83ketone body metabolic process (GO:1902224)3.82158502
84drug transport (GO:0015893)3.78211737
85plasma lipoprotein particle clearance (GO:0034381)3.78102800
86carnitine metabolic process (GO:0009437)3.76250904
87aldehyde catabolic process (GO:0046185)3.75434959
88regulation of bile acid biosynthetic process (GO:0070857)3.74306950
89synaptic vesicle docking involved in exocytosis (GO:0016081)3.73252778
90fatty acid beta-oxidation (GO:0006635)3.72751045
91flavonoid metabolic process (GO:0009812)3.71969615
92fatty acid oxidation (GO:0019395)3.70568793
93lipid oxidation (GO:0034440)3.68311532
94plasma lipoprotein particle assembly (GO:0034377)3.65195283
95regulation of cholesterol homeostasis (GO:2000188)3.63565518
96cholesterol efflux (GO:0033344)3.62434476
97central nervous system myelination (GO:0022010)3.61226968
98axon ensheathment in central nervous system (GO:0032291)3.61226968
99* monocarboxylic acid catabolic process (GO:0072329)3.57381452
100fatty acid catabolic process (GO:0009062)3.52854229
101drug metabolic process (GO:0017144)3.51951491
102branched-chain amino acid catabolic process (GO:0009083)3.51096150
103very-low-density lipoprotein particle assembly (GO:0034379)3.50508503
104pyridine nucleotide biosynthetic process (GO:0019363)3.50490031
105nicotinamide nucleotide biosynthetic process (GO:0019359)3.50490031
106regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.44101650
107vitamin transmembrane transport (GO:0035461)3.43433158
108lung epithelium development (GO:0060428)3.43404017
109regulation of female receptivity (GO:0045924)3.38494541
110angiotensin maturation (GO:0002003)3.35718582
111positive regulation of guanylate cyclase activity (GO:0031284)3.27933032
112female mating behavior (GO:0060180)3.24135026
113alkaloid metabolic process (GO:0009820)3.22287578
114vocalization behavior (GO:0071625)2.99648513
115gamma-aminobutyric acid transport (GO:0015812)2.96967078
116NADH metabolic process (GO:0006734)2.95120650
117primary alcohol catabolic process (GO:0034310)2.94375240
118renal system process involved in regulation of blood volume (GO:0001977)2.92203286
119sodium ion homeostasis (GO:0055078)2.91202216
120postsynaptic membrane organization (GO:0001941)2.90335484
121ethanol metabolic process (GO:0006067)2.89225942
122alanine transport (GO:0032328)2.88770107
123membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.82592447
124proline transport (GO:0015824)2.82336142
125cell migration in hindbrain (GO:0021535)2.81359828
126heme transport (GO:0015886)2.80067623
127iron coordination entity transport (GO:1901678)2.79143714
128fat-soluble vitamin biosynthetic process (GO:0042362)2.76746641
129regulation of gene silencing by RNA (GO:0060966)2.76605185
130regulation of posttranscriptional gene silencing (GO:0060147)2.76605185
131regulation of gene silencing by miRNA (GO:0060964)2.76605185
132regulation of cGMP biosynthetic process (GO:0030826)2.75933644
133omega-hydroxylase P450 pathway (GO:0097267)2.74405566
134C4-dicarboxylate transport (GO:0015740)2.73862198
135calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.72416937
136neurotransmitter catabolic process (GO:0042135)2.72326158
137neurotransmitter-gated ion channel clustering (GO:0072578)2.72144687
138L-ascorbic acid metabolic process (GO:0019852)2.66741166
139L-amino acid import (GO:0043092)2.61791898
140cilium or flagellum-dependent cell motility (GO:0001539)2.60927010
141oxidative demethylation (GO:0070989)2.60296574
142vitamin transport (GO:0051180)2.59320295
143one-carbon compound transport (GO:0019755)2.59172513
144fructose metabolic process (GO:0006000)2.58771580
145cGMP-mediated signaling (GO:0019934)2.58514435
146cellular response to nitric oxide (GO:0071732)2.53206738
147neurotransmitter secretion (GO:0007269)2.52175766
148phosphate ion transmembrane transport (GO:0035435)2.48344771
149ovulation cycle (GO:0042698)2.44500430
150response to dietary excess (GO:0002021)2.44302829
151regulation of short-term neuronal synaptic plasticity (GO:0048172)2.42954174
152regulation of neurotransmitter levels (GO:0001505)2.40710685
153positive regulation of triglyceride lipase activity (GO:0061365)2.40103898
154positive regulation of lipoprotein lipase activity (GO:0051006)2.40103898
155neurotransmitter transport (GO:0006836)2.39696588
156nucleobase catabolic process (GO:0046113)2.39537549
157positive regulation of triglyceride metabolic process (GO:0090208)2.39405761
158trivalent inorganic anion homeostasis (GO:0072506)2.38854740
159phosphate ion homeostasis (GO:0055062)2.38854740
160cornea development in camera-type eye (GO:0061303)2.38706045
161auditory behavior (GO:0031223)2.37772089
162maintenance of gastrointestinal epithelium (GO:0030277)2.37732814
163hormone catabolic process (GO:0042447)2.37698493
164transepithelial transport (GO:0070633)2.37022085
165arginine catabolic process (GO:0006527)2.36364229
166renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.35561270
167diacylglycerol metabolic process (GO:0046339)2.32714636
168intestinal absorption (GO:0050892)2.32634902
169glutathione biosynthetic process (GO:0006750)2.32530164
170synaptic vesicle maturation (GO:0016188)2.30111405
171presynaptic membrane assembly (GO:0097105)2.29754435
172regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.29273738

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.23540047
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.09379943
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.67674887
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.27649320
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.44385564
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.14653804
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.81948422
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.92459469
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.79049224
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.00165119
11DROSHA_22980978_ChIP-Seq_HELA_Human2.94570110
12EZH2_22144423_ChIP-Seq_EOC_Human2.59481497
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.41845338
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.24721838
15EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.20705437
16MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.16597217
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.11823905
18HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.11625827
19TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.09686656
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.07022494
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.07017004
22CTCF_27219007_Chip-Seq_Bcells_Human2.01069386
23ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.7984848
24SUZ12_27294783_Chip-Seq_ESCs_Mouse1.95774853
25REST_21632747_ChIP-Seq_MESCs_Mouse1.88912948
26TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.78046212
27SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.73078429
28JARID2_20075857_ChIP-Seq_MESCs_Mouse1.65877349
29CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.63348992
30CLOCK_20551151_ChIP-Seq_293T_Human1.62665167
31SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.62501104
32SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.56272477
33EZH2_18974828_ChIP-Seq_MESCs_Mouse1.53811352
34RNF2_18974828_ChIP-Seq_MESCs_Mouse1.53811352
35MTF2_20144788_ChIP-Seq_MESCs_Mouse1.52538858
36SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.52000517
37FOXA2_19822575_ChIP-Seq_HepG2_Human1.51201507
38RNF2_27304074_Chip-Seq_ESCs_Mouse1.49848263
39HTT_18923047_ChIP-ChIP_STHdh_Human1.44400678
40VDR_22108803_ChIP-Seq_LS180_Human1.43679285
41HNF4A_19822575_ChIP-Seq_HepG2_Human1.43223096
42* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.43165332
43RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.39643302
44EZH2_27304074_Chip-Seq_ESCs_Mouse1.36652938
45THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.32555397
46GATA1_22025678_ChIP-Seq_K562_Human1.32208383
47* REST_18959480_ChIP-ChIP_MESCs_Mouse1.31805414
48JARID2_20064375_ChIP-Seq_MESCs_Mouse1.30034342
49SMC4_20622854_ChIP-Seq_HELA_Human1.26420747
50CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.26121856
51RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.23420796
52RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22284401
53PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.22000120
54SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.21640403
55RXRA_24833708_ChIP-Seq_LIVER_Mouse1.20106598
56CTCF_20526341_ChIP-Seq_ESCs_Human1.17287483
57* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.16681926
58SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.16160510
59ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.16125215
60RARB_27405468_Chip-Seq_BRAIN_Mouse1.14796035
61OCT4_19829295_ChIP-Seq_ESCs_Human1.13916805
62SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.13815221
63P68_20966046_ChIP-Seq_HELA_Human1.12189021
64TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.11869841
65CREB1_26743006_Chip-Seq_LNCaP_Human1.11793791
66IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.10892605
67PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10339582
68RING1B_27294783_Chip-Seq_ESCs_Mouse1.10004718
69ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09329951
70SA1_27219007_Chip-Seq_Bcells_Human1.08533010
71GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08484204
72TP63_22573176_ChIP-Seq_HFKS_Human1.06480254
73ESR1_15608294_ChIP-ChIP_MCF-7_Human1.04788919
74GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.04092860
75MYC_19829295_ChIP-Seq_ESCs_Human1.03021424
76STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.01975158
77ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01259320
78SOX2_27498859_Chip-Seq_STOMACH_Mouse1.00926480
79ZFP281_18757296_ChIP-ChIP_E14_Mouse0.99784771
80RARG_19884340_ChIP-ChIP_MEFs_Mouse0.99489069
81WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98710020
82* EED_16625203_ChIP-ChIP_MESCs_Mouse0.98545414
83ERA_21632823_ChIP-Seq_H3396_Human0.96377248
84GATA4_25053715_ChIP-Seq_YYC3_Human0.96323569
85* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.93288897
86NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.92461392
87ESR2_21235772_ChIP-Seq_MCF-7_Human0.91562214
88EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.91264189
89RUNX1_27514584_Chip-Seq_MCF-7_Human0.91076922
90SMAD3_21741376_ChIP-Seq_ESCs_Human0.90511340
91KLF5_25053715_ChIP-Seq_YYC3_Human0.90473793
92POU5F1_16518401_ChIP-PET_MESCs_Mouse0.90189705
93ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.90173674
94GBX2_23144817_ChIP-Seq_PC3_Human0.89520561
95* TET1_21490601_ChIP-Seq_MESCs_Mouse0.89520109
96NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.89186383
97P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.87767472
98CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.87217282
99PHF8_20622854_ChIP-Seq_HELA_Human0.86096385
100OCT4_20526341_ChIP-Seq_ESCs_Human0.84548556
101AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.84524274
102AR_19668381_ChIP-Seq_PC3_Human0.83656933
103AUTS2_25519132_ChIP-Seq_293T-REX_Human0.83581423
104SMAD4_21741376_ChIP-Seq_HESCs_Human0.83401479
105KDM2B_26808549_Chip-Seq_K562_Human0.83361469
106BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.82814559
107ZNF263_19887448_ChIP-Seq_K562_Human0.82652212
108SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.82599754
109SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.82520279
110AHR_22903824_ChIP-Seq_MCF-7_Human0.81335658
111SA1_27219007_Chip-Seq_ERYTHROID_Human0.81157631
112KAP1_22055183_ChIP-Seq_ESCs_Mouse0.78765851
113RAD21_21589869_ChIP-Seq_MESCs_Mouse0.74572373
114* RARA_24833708_ChIP-Seq_LIVER_Mouse0.72524290
115BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.72040916
116LXR_22292898_ChIP-Seq_THP-1_Human0.71587108
117ESR1_21235772_ChIP-Seq_MCF-7_Human0.71056429
118IRF8_22096565_ChIP-ChIP_GC-B_Human0.70726732
119AR_20517297_ChIP-Seq_VCAP_Human0.70474403
120E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.69361955
121* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.69359422
122CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.65849999
123SALL4_18804426_ChIP-ChIP_XEN_Mouse0.64857133
124RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.62580101
125CEBPB_22108803_ChIP-Seq_LS180_Human0.61864449
126* RARB_24833708_ChIP-Seq_LIVER_Mouse0.58771092
127* CDX2_20551321_ChIP-Seq_CACO-2_Human0.57543441
128GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.55814570
129GATA1_19941827_ChIP-Seq_MEL_Mouse0.55047901
130PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.54720562
131ESET_19884257_ChIP-Seq_ESCs_Mouse0.53927617
132FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.53142536
133Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.53108482
134SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.51496867
135TAF2_19829295_ChIP-Seq_ESCs_Human0.51056013
136ERG_21242973_ChIP-ChIP_JURKAT_Human0.50375373
137PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.49637429
138CBP_21632823_ChIP-Seq_H3396_Human0.49480533
139MYC_19915707_ChIP-ChIP_AK7_Human0.49305054
140IRF1_19129219_ChIP-ChIP_H3396_Human0.48105318
141PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.47874590
142FOXA1_25552417_ChIP-Seq_VCAP_Human0.47692294
143EGR1_19032775_ChIP-ChIP_M12_Human0.47330060
144TET1_21451524_ChIP-Seq_MESCs_Mouse0.46871715
145SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.46554129
146SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.46145205
147P53_21459846_ChIP-Seq_SAOS-2_Human0.45839665
148AR_21909140_ChIP-Seq_LNCAP_Human0.45419715
149FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.45238340
150STAT1_17558387_ChIP-Seq_HELA_Human0.44449063
151NRF2_20460467_ChIP-Seq_MEFs_Mouse0.44212659
152NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.44212659
153ERG_20517297_ChIP-Seq_VCAP_Human0.43000884
154PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.42846343
155GATA2_19941826_ChIP-Seq_K562_Human0.42792529
156FOXO3_23340844_ChIP-Seq_DLD1_Human0.42655519
157GATA6_25053715_ChIP-Seq_YYC3_Human0.41785326
158SOX2_22085726_ChIP-Seq_NPCs_Mouse0.41669831
159RACK7_27058665_Chip-Seq_MCF-7_Human0.41632425
160MYC_27129775_Chip-Seq_CORNEA_Mouse0.41270537
161GATA1_19941826_ChIP-Seq_K562_Human0.40328334
162RAC3_21632823_ChIP-Seq_H3396_Human0.39815246
163POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.39654957
164LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.39401862
165BCL6_27268052_Chip-Seq_Bcells_Human0.38998671
166FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.38996450
167BCOR_27268052_Chip-Seq_Bcells_Human0.38755254
168FOXH1_21741376_ChIP-Seq_EPCs_Human0.38718585
169CSB_26484114_Chip-Seq_FIBROBLAST_Human0.38418699

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.99591602
2MP0005360_urolithiasis7.79663686
3MP0005085_abnormal_gallbladder_physiolo5.97069164
4MP0005365_abnormal_bile_salt5.85926553
5MP0008875_abnormal_xenobiotic_pharmacok5.09254207
6MP0003806_abnormal_nucleotide_metabolis4.08299242
7MP0003252_abnormal_bile_duct3.79894241
8MP0010329_abnormal_lipoprotein_level3.36391020
9* MP0005332_abnormal_amino_acid3.29745876
10MP0009840_abnormal_foam_cell3.14722257
11MP0003195_calcinosis2.79201194
12MP0009379_abnormal_foot_pigmentation2.65827897
13MP0004019_abnormal_vitamin_homeostasis2.63515949
14MP0005083_abnormal_biliary_tract2.59240098
15MP0004270_analgesia2.55153359
16MP0005377_hearing/vestibular/ear_phenot2.54880102
17MP0003878_abnormal_ear_physiology2.54880102
18MP0001666_abnormal_nutrient_absorption2.46851040
19MP0003136_yellow_coat_color2.46694721
20MP0004859_abnormal_synaptic_plasticity2.11481855
21MP0003880_abnormal_central_pattern2.11441501
22MP0003191_abnormal_cellular_cholesterol2.10021248
23MP0002118_abnormal_lipid_homeostasis2.02890627
24MP0000609_abnormal_liver_physiology2.01697326
25MP0002138_abnormal_hepatobiliary_system1.97420504
26MP0005319_abnormal_enzyme/_coenzyme1.92091026
27MP0009745_abnormal_behavioral_response1.89828877
28MP0001764_abnormal_homeostasis1.86726061
29MP0004147_increased_porphyrin_level1.84289603
30MP0002064_seizures1.81347831
31MP0009780_abnormal_chondrocyte_physiolo1.78350810
32MP0001968_abnormal_touch/_nociception1.75041782
33MP0001485_abnormal_pinna_reflex1.74827209
34MP0005646_abnormal_pituitary_gland1.74697255
35MP0003879_abnormal_hair_cell1.72928392
36MP0009643_abnormal_urine_homeostasis1.72142741
37* MP0001486_abnormal_startle_reflex1.70153258
38MP0005584_abnormal_enzyme/coenzyme_acti1.69649040
39MP0003868_abnormal_feces_composition1.69016508
40MP0001501_abnormal_sleep_pattern1.68509364
41MP0003635_abnormal_synaptic_transmissio1.67491204
42MP0003183_abnormal_peptide_metabolism1.64968938
43MP0002272_abnormal_nervous_system1.64869685
44MP0003186_abnormal_redox_activity1.64622220
45MP0005423_abnormal_somatic_nervous1.61736460
46MP0002734_abnormal_mechanical_nocicepti1.51479233
47MP0005451_abnormal_body_composition1.51233229
48MP0002638_abnormal_pupillary_reflex1.50170655
49MP0001984_abnormal_olfaction1.48572793
50MP0002736_abnormal_nociception_after1.44764105
51MP0004133_heterotaxia1.43763083
52MP0004885_abnormal_endolymph1.41006708
53MP0002063_abnormal_learning/memory/cond1.40377211
54MP0002249_abnormal_larynx_morphology1.39136128
55MP0002653_abnormal_ependyma_morphology1.38326723
56MP0005647_abnormal_sex_gland1.35729357
57MP0009697_abnormal_copulation1.35450276
58MP0002572_abnormal_emotion/affect_behav1.34287905
59MP0002098_abnormal_vibrissa_morphology1.34070474
60MP0003011_delayed_dark_adaptation1.33974391
61MP0000678_abnormal_parathyroid_gland1.33201361
62MP0003283_abnormal_digestive_organ1.33069458
63MP0002254_reproductive_system_inflammat1.31965880
64MP0003119_abnormal_digestive_system1.31282780
65MP0005636_abnormal_mineral_homeostasis1.28454362
66MP0005551_abnormal_eye_electrophysiolog1.27463803
67MP0002735_abnormal_chemical_nociception1.27386655
68MP0002557_abnormal_social/conspecific_i1.26691808
69MP0009764_decreased_sensitivity_to1.19677721
70MP0005670_abnormal_white_adipose1.19584959
71MP0002909_abnormal_adrenal_gland1.14627633
72MP0002733_abnormal_thermal_nociception1.14357818
73MP0000383_abnormal_hair_follicle1.13292983
74MP0004043_abnormal_pH_regulation1.12088685
75MP0001502_abnormal_circadian_rhythm1.11203701
76MP0000598_abnormal_liver_morphology1.10323846
77MP0003656_abnormal_erythrocyte_physiolo1.08668767
78MP0001986_abnormal_taste_sensitivity1.07578598
79MP0006036_abnormal_mitochondrial_physio1.07274875
80MP0003938_abnormal_ear_development1.07246119
81MP0001970_abnormal_pain_threshold1.06493225
82MP0000026_abnormal_inner_ear1.01323508
83MP0002938_white_spotting0.99161420
84MP0000604_amyloidosis0.98777532
85MP0001756_abnormal_urination0.97937299
86MP0004924_abnormal_behavior0.97758351
87MP0005386_behavior/neurological_phenoty0.97758351
88MP0009046_muscle_twitch0.95610625
89MP0003646_muscle_fatigue0.93799932
90MP0006292_abnormal_olfactory_placode0.93723016
91MP0009763_increased_sensitivity_to0.90995789
92MP0003705_abnormal_hypodermis_morpholog0.90870131
93MP0001963_abnormal_hearing_physiology0.90525369
94MP0002089_abnormal_postnatal_growth/wei0.89855393
95MP0001188_hyperpigmentation0.89444982
96MP0002876_abnormal_thyroid_physiology0.88764513
97MP0008469_abnormal_protein_level0.88647451
98* MP0009642_abnormal_blood_homeostasis0.88510390
99MP0005187_abnormal_penis_morphology0.87125114
100MP0002136_abnormal_kidney_physiology0.86665379
101MP0001664_abnormal_digestion0.85587972
102MP0003787_abnormal_imprinting0.84774799
103MP0004858_abnormal_nervous_system0.83492700
104MP0002067_abnormal_sensory_capabilities0.82869710
105MP0005376_homeostasis/metabolism_phenot0.82177463
106MP0003690_abnormal_glial_cell0.79965055
107MP0009765_abnormal_xenobiotic_induced0.76111734
108MP0005645_abnormal_hypothalamus_physiol0.75901529
109MP0003329_amyloid_beta_deposits0.74947664
110MP0000462_abnormal_digestive_system0.74904491
111MP0003137_abnormal_impulse_conducting0.74848521
112MP0005220_abnormal_exocrine_pancreas0.74635841
113MP0002971_abnormal_brown_adipose0.74297569
114MP0005535_abnormal_body_temperature0.74267877
115MP0002078_abnormal_glucose_homeostasis0.73510731
116MP0005084_abnormal_gallbladder_morpholo0.72895818
117MP0001765_abnormal_ion_homeostasis0.72692378
118MP0002229_neurodegeneration0.72408049
119MP0002069_abnormal_eating/drinking_beha0.72191478
120MP0000778_abnormal_nervous_system0.71204514
121MP0002066_abnormal_motor_capabilities/c0.70759345
122MP0000647_abnormal_sebaceous_gland0.70582009
123MP0010678_abnormal_skin_adnexa0.70436503
124MP0001440_abnormal_grooming_behavior0.69816002
125MP0002882_abnormal_neuron_morphology0.68780391
126MP0004130_abnormal_muscle_cell0.68341196
127MP0005266_abnormal_metabolism0.66223389
128MP0005334_abnormal_fat_pad0.65320510
129MP0001661_extended_life_span0.64665385
130MP0003638_abnormal_response/metabolism_0.64037069
131MP0005666_abnormal_adipose_tissue0.62765530
132MP0005408_hypopigmentation0.62096153
133MP0010368_abnormal_lymphatic_system0.61415943
134MP0006035_abnormal_mitochondrial_morpho0.61282996
135MP0003075_altered_response_to0.58889650
136MP0005058_abnormal_lysosome_morphology0.57196539
137MP0002928_abnormal_bile_duct0.56483040
138MP0001853_heart_inflammation0.55855994
139MP0003300_gastrointestinal_ulcer0.54274528
140MP0003718_maternal_effect0.53544422
141MP0005395_other_phenotype0.52155277
142MP0000230_abnormal_systemic_arterial0.48593215
143MP0008872_abnormal_physiological_respon0.47571225
144MP0005166_decreased_susceptibility_to0.47307108
145MP0005464_abnormal_platelet_physiology0.45976485
146MP0008874_decreased_physiological_sensi0.44250383
147MP0004782_abnormal_surfactant_physiolog0.43959647
148MP0003953_abnormal_hormone_level0.43728560
149MP0005448_abnormal_energy_balance0.42179122
150MP0002132_abnormal_respiratory_system0.41702951
151MP0000639_abnormal_adrenal_gland0.41674215
152MP0009115_abnormal_fat_cell0.40191349
153MP0002796_impaired_skin_barrier0.39979385
154MP0008873_increased_physiological_sensi0.38327424
155MP0002135_abnormal_kidney_morphology0.38170766
156MP0009384_cardiac_valve_regurgitation0.37853276
157MP0009053_abnormal_anal_canal0.37408951
158MP0003724_increased_susceptibility_to0.37262843
159MP0002168_other_aberrant_phenotype0.36217277
160MP0000566_synostosis0.36056187
161MP0002837_dystrophic_cardiac_calcinosis0.33854414
162MP0002822_catalepsy0.33282192
163MP0000538_abnormal_urinary_bladder0.32709596
164MP0004264_abnormal_extraembryonic_tissu0.31320908
165MP0002970_abnormal_white_adipose0.30708162
166MP0003436_decreased_susceptibility_to0.30605332
167MP0001845_abnormal_inflammatory_respons0.29290644
168MP0009672_abnormal_birth_weight0.29147336
169MP0000579_abnormal_nail_morphology0.28323186
170MP0001881_abnormal_mammary_gland0.27113202
171MP0000249_abnormal_blood_vessel0.26954291

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.98058410
2Intrahepatic cholestasis (HP:0001406)6.64185473
3Deep venous thrombosis (HP:0002625)6.21252955
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.11043806
5Xanthomatosis (HP:0000991)5.92388734
6Prolonged partial thromboplastin time (HP:0003645)5.63681069
7Hypobetalipoproteinemia (HP:0003563)5.54766621
8Hyperlipoproteinemia (HP:0010980)5.12463444
9Hyperglycinemia (HP:0002154)4.92424879
10Hyperammonemia (HP:0001987)4.91632141
11* Hyperglycinuria (HP:0003108)4.75507462
12Ketosis (HP:0001946)4.71840638
13* Abnormality of glycine metabolism (HP:0010895)4.55607186
14* Abnormality of serine family amino acid metabolism (HP:0010894)4.55607186
15Abnormality of sulfur amino acid metabolism (HP:0004339)4.43262559
16Abnormality of aspartate family amino acid metabolism (HP:0010899)4.41025009
17Complement deficiency (HP:0004431)4.40940942
18* Abnormality of glutamine family amino acid metabolism (HP:0010902)4.36821347
19Hypolipoproteinemia (HP:0010981)4.30119642
20Joint hemorrhage (HP:0005261)4.23907736
21Abnormality of methionine metabolism (HP:0010901)4.11689861
22Epidermoid cyst (HP:0200040)3.94336275
23Hypoalphalipoproteinemia (HP:0003233)3.90067687
24Hypoglycemic coma (HP:0001325)3.89420322
25Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.89007705
26Abnormality of fatty-acid metabolism (HP:0004359)3.87577103
27Abnormality of pyrimidine metabolism (HP:0004353)3.79027150
28Fat malabsorption (HP:0002630)3.74438998
29Ketoacidosis (HP:0001993)3.68935708
30Abnormality of the common coagulation pathway (HP:0010990)3.65891108
31Bronchomalacia (HP:0002780)3.56143947
32Gout (HP:0001997)3.53915919
33Delayed CNS myelination (HP:0002188)3.51363007
34Abnormality of nucleobase metabolism (HP:0010932)3.45418277
35Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.42435389
36Myokymia (HP:0002411)3.35305694
37Abnormality of serum amino acid levels (HP:0003112)3.35141939
38Abnormality of the intrinsic pathway (HP:0010989)3.33180760
39Abnormality of purine metabolism (HP:0004352)3.28613841
40Hypercholesterolemia (HP:0003124)3.28469288
41Dicarboxylic aciduria (HP:0003215)3.21444308
42Abnormality of dicarboxylic acid metabolism (HP:0010995)3.21444308
43Hyperbilirubinemia (HP:0002904)3.19294788
44Conjugated hyperbilirubinemia (HP:0002908)3.17613306
45Abnormality of complement system (HP:0005339)3.13586680
46Metabolic acidosis (HP:0001942)3.12364518
47* Hydroxyprolinuria (HP:0003080)3.11456160
48* Abnormality of proline metabolism (HP:0010907)3.11456160
49Generalized aminoaciduria (HP:0002909)2.96499321
50Lethargy (HP:0001254)2.96278141
51Proximal tubulopathy (HP:0000114)2.87078267
52Steatorrhea (HP:0002570)2.86482035
53Vascular calcification (HP:0004934)2.83703931
54Hepatocellular carcinoma (HP:0001402)2.73130085
55Decreased circulating renin level (HP:0003351)2.72965708
56Alkalosis (HP:0001948)2.69080252
57Ankle clonus (HP:0011448)2.58827129
58Myocardial infarction (HP:0001658)2.58481775
59Cerebral edema (HP:0002181)2.55895760
60Amelogenesis imperfecta (HP:0000705)2.52008107
61Hyperventilation (HP:0002883)2.51823044
62Abnormal respiratory epithelium morphology (HP:0012253)2.51685415
63Abnormal respiratory motile cilium morphology (HP:0005938)2.51685415
64Increased purine levels (HP:0004368)2.49867830
65Hyperuricemia (HP:0002149)2.49867830
66Spastic diplegia (HP:0001264)2.49419736
67Malnutrition (HP:0004395)2.47705460
68Neonatal onset (HP:0003623)2.46785412
69Cardiovascular calcification (HP:0011915)2.46283241
70Vomiting (HP:0002013)2.44789672
71Widely patent fontanelles and sutures (HP:0004492)2.43594887
72Irritability (HP:0000737)2.43573746
73Late onset (HP:0003584)2.40690352
74Focal seizures (HP:0007359)2.40107859
75Abnormality of the vitamin B12 metabolism (HP:0004341)2.38450954
76Sensorimotor neuropathy (HP:0007141)2.38061719
77Spontaneous abortion (HP:0005268)2.37007973
78Abnormality of renin-angiotensin system (HP:0000847)2.36941423
79Enlarged kidneys (HP:0000105)2.36503139
80Hypoglycemic seizures (HP:0002173)2.34806831
81Skin nodule (HP:0200036)2.34019822
82Potter facies (HP:0002009)2.31328457
83Facial shape deformation (HP:0011334)2.31328457
84Systemic lupus erythematosus (HP:0002725)2.30674607
85Abnormality of vitamin B metabolism (HP:0004340)2.30669440
86Pancreatitis (HP:0001733)2.30340898
87Abnormality of urine glucose concentration (HP:0011016)2.25386649
88Glycosuria (HP:0003076)2.25386649
89Dynein arm defect of respiratory motile cilia (HP:0012255)2.25187693
90Absent/shortened dynein arms (HP:0200106)2.25187693
91Focal motor seizures (HP:0011153)2.21897560
92Hypochromic microcytic anemia (HP:0004840)2.17062285
93Hypoplastic ischia (HP:0003175)2.15291699
94Ependymoma (HP:0002888)2.14769922
95Aplasia involving bones of the extremities (HP:0009825)2.14711738
96Aplasia involving bones of the upper limbs (HP:0009823)2.14711738
97Aplasia of the phalanges of the hand (HP:0009802)2.14711738
98Rickets (HP:0002748)2.11159071
99Abnormal ciliary motility (HP:0012262)2.10111417
100Amyloidosis (HP:0011034)2.09751121
101Split foot (HP:0001839)2.07348105
102Abnormality of the ischium (HP:0003174)2.06289345
103Epileptic encephalopathy (HP:0200134)2.05495082
104Esophageal varix (HP:0002040)2.05261051
105Mitral stenosis (HP:0001718)2.04819909
106Brushfield spots (HP:0001088)2.03032457
107Abnormal gallbladder morphology (HP:0012437)2.02683224
108Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.02476283
109Acanthocytosis (HP:0001927)2.00799161
110Confusion (HP:0001289)2.00798436
111Cholelithiasis (HP:0001081)2.00481301
112Opisthotonus (HP:0002179)1.99737418
113Megaloblastic anemia (HP:0001889)1.99388779
114Abnormal enzyme/coenzyme activity (HP:0012379)1.98779228
115Heart block (HP:0012722)1.97993896
116Febrile seizures (HP:0002373)1.97525144
117Back pain (HP:0003418)1.96889446
118Progressive cerebellar ataxia (HP:0002073)1.96386055
119Abnormal urine phosphate concentration (HP:0012599)1.95464629
120Renal cortical cysts (HP:0000803)1.95195256
121Glomerulonephritis (HP:0000099)1.94437347
122Action tremor (HP:0002345)1.92881794
123Abnormality of the dental pulp (HP:0006479)1.92403952
124Hyperactive renin-angiotensin system (HP:0000841)1.91433158
125Elevated hepatic transaminases (HP:0002910)1.90162934
126Thrombophlebitis (HP:0004418)1.89911299
127Methylmalonic aciduria (HP:0012120)1.89738052
128Abnormality of vitamin metabolism (HP:0100508)1.86747283
129Stomach cancer (HP:0012126)1.86733614
130Nephronophthisis (HP:0000090)1.86448537
131Menorrhagia (HP:0000132)1.85679942
132Chronic bronchitis (HP:0004469)1.85481271
133Nausea (HP:0002018)1.84910506
134Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.84701790
135Abnormal cartilage morphology (HP:0002763)1.84503884
136Abnormal gallbladder physiology (HP:0012438)1.83974847
137Cholecystitis (HP:0001082)1.83974847
138Abnormality of the dental root (HP:0006486)1.83556417
139Taurodontia (HP:0000679)1.83556417
140Abnormality of permanent molar morphology (HP:0011071)1.83556417
141Abnormal respiratory motile cilium physiology (HP:0012261)1.83530339
142Bell-shaped thorax (HP:0001591)1.82980945
143Decreased central vision (HP:0007663)1.80727892
144Gingival bleeding (HP:0000225)1.79734528
145Hypophosphatemic rickets (HP:0004912)1.78999771
146Focal segmental glomerulosclerosis (HP:0000097)1.78720579
147Protuberant abdomen (HP:0001538)1.78008477
148Hyperinsulinemic hypoglycemia (HP:0000825)1.77953857
149Nephrolithiasis (HP:0000787)1.77479917
150Cystic liver disease (HP:0006706)1.75891075
151Abnormality of renal excretion (HP:0011036)1.75375687
152Abnormality of alkaline phosphatase activity (HP:0004379)1.75333584
153Tubular atrophy (HP:0000092)1.75139498
154Abnormal urine output (HP:0012590)1.74934076
155Pendular nystagmus (HP:0012043)1.74882676
156Genetic anticipation (HP:0003743)1.74571660
157Abnormality of the middle phalanges of the toes (HP:0010183)1.73832191
158Turricephaly (HP:0000262)1.72930321
159Lymphangioma (HP:0100764)1.72847706
160Rhinitis (HP:0012384)1.71028797
161Mixed hearing impairment (HP:0000410)1.70107515
162Partial duplication of thumb phalanx (HP:0009944)1.70038619
163Abnormal eating behavior (HP:0100738)1.69414210
164Septo-optic dysplasia (HP:0100842)1.69112466
165Abnormal atrioventricular conduction (HP:0005150)1.68496769

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK8.00139057
2SIK14.56269907
3ERN14.12494807
4EPHA23.77587891
5FGFR43.51241101
6NTRK32.99779072
7INSRR2.59204232
8TAOK32.55054361
9STK38L2.36984204
10LATS22.28755096
11MARK12.27732394
12CASK2.27335761
13ACVR1B2.27080745
14NME12.23445838
15TRIB32.16716409
16ERBB42.12254950
17WNK32.11095348
18MST1R1.95371368
19WNK41.94002102
20PKN21.92229932
21MAP3K71.87670665
22MAPK111.81099183
23NTRK21.77332364
24FLT31.63041614
25PINK11.62442566
26MAPK131.60171740
27OXSR11.57673097
28PRKG21.51165892
29MAP2K41.47131046
30TNIK1.44368677
31EPHA41.44313855
32PIK3CG1.42584653
33TYRO31.35691303
34MATK1.35236162
35GRK61.29219957
36PRKCI1.24418381
37TYK21.24116248
38ABL21.23416024
39BMPR1B1.22321371
40LMTK21.20206197
41LATS11.19899847
42PTK61.18724810
43KDR1.18605201
44FRK1.17635892
45PRKAA21.15186978
46IRAK31.14396030
47MAPK121.09180025
48MAP2K31.07932955
49EEF2K1.03861763
50PAK61.00478626
51PDK30.99782010
52PDK40.99782010
53MAPK40.99101477
54TIE10.98784613
55JAK20.95507652
56ADRBK20.95245182
57SIK20.94379051
58STK110.93069434
59PRKCG0.92713699
60PAK30.91993226
61UHMK10.91266140
62NUAK10.90867945
63CAMK2B0.85852805
64NEK90.85435458
65SGK30.84334268
66CAMK2A0.84170398
67ERBB20.82282154
68MAP2K60.81085536
69FER0.81078360
70DAPK10.80930872
71FGFR20.80742315
72MINK10.80335892
73CDK50.79983845
74TBK10.79315908
75SGK20.79255424
76MAPKAPK30.78574778
77NEK60.78482974
78RPS6KA20.77556245
79MAP3K30.77007727
80STK160.74780798
81MAP3K140.74661052
82CAMKK10.74414188
83SGK4940.70706826
84SGK2230.70706826
85TGFBR20.70554413
86PRKAA10.70235935
87PRKD30.69775207
88DYRK20.69508759
89BMX0.69102799
90PIK3CA0.68264298
91PRKCZ0.67944164
92PRKACG0.67509017
93DAPK20.67326174
94TAOK20.67259354
95STK380.67203680
96CAMK10.66280640
97MYLK0.66163533
98MUSK0.66111219
99OBSCN0.65283497
100PDPK10.64946525
101MARK20.63891774
102CSNK1A10.63402063
103CAMK1D0.62695895
104PRKACA0.62281473
105NTRK10.61768308
106SGK10.61515357
107TLK10.60921219
108GRK10.60793643
109JAK10.58999720
110PTK20.54721084
111PKN10.54169812
112MAPKAPK50.54142335
113BCR0.53115945
114FGFR10.52106158
115MAPK70.52096018
116PDK20.50878577
117MAP2K20.50713527
118NEK10.50674207
119CDK40.49855078
120MAPK150.48906918
121CAMK2D0.48539544
122RIPK10.46779205
123CAMK2G0.45727200
124FGFR30.45525735
125MAPK80.45506299
126GSK3A0.45321484
127MAP3K110.44547041
128PRKCQ0.44295986
129AKT30.44285142
130MAP3K40.44240619
131RPS6KA60.44121590
132PDK10.44003119
133PHKG10.43984197
134PHKG20.43984197
135DYRK1A0.43592383
136TEC0.43202664
137CSNK1E0.41044313
138MAPK100.40869878
139MST40.40868690
140CDK150.40308358
141RPS6KA30.39635008
142LRRK20.39570572
143MET0.39072580
144GSK3B0.38994798
145PRKCE0.38762695
146EPHB10.37449389
147IGF1R0.36920804
148IKBKE0.36499096
149CSK0.36353035
150MAP3K130.36338095
151BTK0.34279303
152CSF1R0.34202074
153CDK60.34130828
154PRKCA0.28845323
155AKT20.28496121
156MAP3K60.28490252
157KIT0.26293235
158CAMK40.25500263
159STK390.24394074
160DYRK1B0.24202638
161MAP3K100.24032634

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.04327196
2Nitrogen metabolism_Homo sapiens_hsa009103.60537094
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.40309732
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.06589792
5Arginine biosynthesis_Homo sapiens_hsa002202.89148070
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.72162612
7Fatty acid degradation_Homo sapiens_hsa000712.71765652
8Tryptophan metabolism_Homo sapiens_hsa003802.64019281
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.63591819
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.60224501
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.51682821
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.41705719
13Propanoate metabolism_Homo sapiens_hsa006402.29594094
14Complement and coagulation cascades_Homo sapiens_hsa046102.28516367
15Butanoate metabolism_Homo sapiens_hsa006502.28247962
16Peroxisome_Homo sapiens_hsa041462.22556095
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.02016628
18Fatty acid metabolism_Homo sapiens_hsa012121.99888870
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.88944637
20PPAR signaling pathway_Homo sapiens_hsa033201.88248044
21Chemical carcinogenesis_Homo sapiens_hsa052041.81667999
22beta-Alanine metabolism_Homo sapiens_hsa004101.80386202
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.79835979
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.77126583
25Histidine metabolism_Homo sapiens_hsa003401.76957243
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.71002506
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.68225263
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.67770948
29Caffeine metabolism_Homo sapiens_hsa002321.64041419
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.62158398
31Nicotine addiction_Homo sapiens_hsa050331.62040456
32Retinol metabolism_Homo sapiens_hsa008301.59837802
33Pyruvate metabolism_Homo sapiens_hsa006201.58894684
34Bile secretion_Homo sapiens_hsa049761.51137992
35Selenocompound metabolism_Homo sapiens_hsa004501.47483750
36Sulfur metabolism_Homo sapiens_hsa009201.46775630
37Phenylalanine metabolism_Homo sapiens_hsa003601.43127626
38Insulin secretion_Homo sapiens_hsa049111.39255971
39Staphylococcus aureus infection_Homo sapiens_hsa051501.38398302
40Cyanoamino acid metabolism_Homo sapiens_hsa004601.37584688
41Carbon metabolism_Homo sapiens_hsa012001.36328398
42Starch and sucrose metabolism_Homo sapiens_hsa005001.36309585
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.36210307
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.34398350
45Biosynthesis of amino acids_Homo sapiens_hsa012301.33761045
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33041278
47Tyrosine metabolism_Homo sapiens_hsa003501.31730343
48Folate biosynthesis_Homo sapiens_hsa007901.27899189
49Fatty acid elongation_Homo sapiens_hsa000621.27192910
50Amphetamine addiction_Homo sapiens_hsa050311.21193860
51Cocaine addiction_Homo sapiens_hsa050301.15146216
52ABC transporters_Homo sapiens_hsa020101.11161334
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08405847
54Steroid biosynthesis_Homo sapiens_hsa001001.08299493
55Sulfur relay system_Homo sapiens_hsa041221.06450080
56Vitamin digestion and absorption_Homo sapiens_hsa049771.02327726
57* Arginine and proline metabolism_Homo sapiens_hsa003300.99630645
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.97860830
59Fat digestion and absorption_Homo sapiens_hsa049750.96935994
60Ether lipid metabolism_Homo sapiens_hsa005650.95300379
61Glutamatergic synapse_Homo sapiens_hsa047240.95126527
62Synaptic vesicle cycle_Homo sapiens_hsa047210.92861640
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.90647815
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.89663504
65Lysine degradation_Homo sapiens_hsa003100.87141610
66Circadian entrainment_Homo sapiens_hsa047130.87039995
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83092553
68Glutathione metabolism_Homo sapiens_hsa004800.82589910
69Fatty acid biosynthesis_Homo sapiens_hsa000610.81645387
70Taste transduction_Homo sapiens_hsa047420.79586393
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.78831630
72Aldosterone synthesis and secretion_Homo sapiens_hsa049250.77880651
73Vitamin B6 metabolism_Homo sapiens_hsa007500.77830338
74One carbon pool by folate_Homo sapiens_hsa006700.77798432
75Glycerolipid metabolism_Homo sapiens_hsa005610.77502496
76Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.72169353
77Pentose phosphate pathway_Homo sapiens_hsa000300.72166174
78GABAergic synapse_Homo sapiens_hsa047270.72051638
79Dopaminergic synapse_Homo sapiens_hsa047280.71745610
80Phototransduction_Homo sapiens_hsa047440.71637731
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71386446
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70519470
83Salivary secretion_Homo sapiens_hsa049700.69196717
84Tight junction_Homo sapiens_hsa045300.69155125
85Serotonergic synapse_Homo sapiens_hsa047260.64785013
86Gastric acid secretion_Homo sapiens_hsa049710.60514530
87Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60476925
88Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.59080359
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55758612
90Sphingolipid metabolism_Homo sapiens_hsa006000.55074868
91Calcium signaling pathway_Homo sapiens_hsa040200.54184170
92* Metabolic pathways_Homo sapiens_hsa011000.53985184
93Cardiac muscle contraction_Homo sapiens_hsa042600.53286741
94Morphine addiction_Homo sapiens_hsa050320.51379427
95Fructose and mannose metabolism_Homo sapiens_hsa000510.50761622
96Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.50200269
97Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.48057672
98Pancreatic secretion_Homo sapiens_hsa049720.46326885
99Renin secretion_Homo sapiens_hsa049240.42487636
100Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.42366079
101cAMP signaling pathway_Homo sapiens_hsa040240.41169662
102Collecting duct acid secretion_Homo sapiens_hsa049660.39056777
103Galactose metabolism_Homo sapiens_hsa000520.38859162
104Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.26959578
105alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25352191
106Adipocytokine signaling pathway_Homo sapiens_hsa049200.24864662
107Insulin resistance_Homo sapiens_hsa049310.21308946
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.15744028
109Linoleic acid metabolism_Homo sapiens_hsa005910.15120540
110Prion diseases_Homo sapiens_hsa050200.10864323
111Glucagon signaling pathway_Homo sapiens_hsa049220.06909533
112Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.03056189
113Glycosaminoglycan degradation_Homo sapiens_hsa005310.01862695
114Renin-angiotensin system_Homo sapiens_hsa046140.01724522
115AMPK signaling pathway_Homo sapiens_hsa041520.00073645
116Pyrimidine metabolism_Homo sapiens_hsa00240-0.2264011
117Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.2220177
118African trypanosomiasis_Homo sapiens_hsa05143-0.2097875
119Lysosome_Homo sapiens_hsa04142-0.1937622
120Circadian rhythm_Homo sapiens_hsa04710-0.1846095
121Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1788669
122Hepatitis C_Homo sapiens_hsa05160-0.1786841
123Regulation of autophagy_Homo sapiens_hsa04140-0.1739525
124Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1331209
125Insulin signaling pathway_Homo sapiens_hsa04910-0.1329914
126Protein digestion and absorption_Homo sapiens_hsa04974-0.1320243
127Mineral absorption_Homo sapiens_hsa04978-0.1093826
128Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1023001
129Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1020674
130Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0817169
131Other glycan degradation_Homo sapiens_hsa00511-0.0621687
132Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0173968
133Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0081053
134Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0022546

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