PRODH2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene catalyzes the first step in the catabolism of trans-4-hydroxy-L-proline, an amino acid derivative obtained through food intake and collagen turnover. One of the downstream products of this catabolism is glyoxylate, which in people with disorders of glyoxalate metabolism can lead to an increase in oxalate levels and the formation of calcium-oxalate kidney stones. Therefore, this gene may serve as a therapeutic target against primary hyperoxalurias (PH). This gene is similar to proline dehydrogenase (oxidase) 1, a mitochondrial enzyme that catalyzes the first step in proline catabolism. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.81034158
2L-phenylalanine catabolic process (GO:0006559)7.81034158
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.41121422
4L-phenylalanine metabolic process (GO:0006558)7.41121422
5aromatic amino acid family catabolic process (GO:0009074)6.92350170
6epoxygenase P450 pathway (GO:0019373)6.64827289
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.30945357
8tryptophan catabolic process (GO:0006569)6.18814588
9indole-containing compound catabolic process (GO:0042436)6.18814588
10indolalkylamine catabolic process (GO:0046218)6.18814588
11regulation of plasminogen activation (GO:0010755)6.10297544
12exogenous drug catabolic process (GO:0042738)6.09557404
13omega-hydroxylase P450 pathway (GO:0097267)6.06522606
14kynurenine metabolic process (GO:0070189)5.88949631
15glyoxylate metabolic process (GO:0046487)5.81868071
16bile acid biosynthetic process (GO:0006699)5.81788661
17tryptophan metabolic process (GO:0006568)5.80847878
18high-density lipoprotein particle remodeling (GO:0034375)5.60139506
19intestinal cholesterol absorption (GO:0030299)5.58497587
20regulation of fibrinolysis (GO:0051917)5.46524668
21negative regulation of fibrinolysis (GO:0051918)5.44112341
22urea metabolic process (GO:0019627)5.22031112
23urea cycle (GO:0000050)5.22031112
24regulation of cholesterol esterification (GO:0010872)5.20125541
25protein carboxylation (GO:0018214)5.18421247
26peptidyl-glutamic acid carboxylation (GO:0017187)5.18421247
27cysteine metabolic process (GO:0006534)5.17943668
28aromatic amino acid family metabolic process (GO:0009072)5.12725260
29alpha-linolenic acid metabolic process (GO:0036109)5.10032050
30serine family amino acid catabolic process (GO:0009071)5.07472223
31nitrogen cycle metabolic process (GO:0071941)5.00791936
32regulation of protein activation cascade (GO:2000257)4.99910132
33sulfur amino acid catabolic process (GO:0000098)4.98524702
34tyrosine metabolic process (GO:0006570)4.96818877
35bile acid metabolic process (GO:0008206)4.95665841
36complement activation, alternative pathway (GO:0006957)4.85852623
37reverse cholesterol transport (GO:0043691)4.85152218
38protein-lipid complex assembly (GO:0065005)4.84098145
39protein-lipid complex remodeling (GO:0034368)4.81131232
40macromolecular complex remodeling (GO:0034367)4.81131232
41plasma lipoprotein particle remodeling (GO:0034369)4.81131232
42regulation of triglyceride catabolic process (GO:0010896)4.75453601
43cellular biogenic amine catabolic process (GO:0042402)4.70875723
44amine catabolic process (GO:0009310)4.70875723
45drug metabolic process (GO:0017144)4.68567989
46protein-lipid complex subunit organization (GO:0071825)4.63484267
47acute-phase response (GO:0006953)4.61709712
48fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.61236069
49regulation of complement activation (GO:0030449)4.60204320
50phospholipid efflux (GO:0033700)4.59344568
51negative regulation of blood coagulation (GO:0030195)4.58986116
52negative regulation of hemostasis (GO:1900047)4.58986116
53triglyceride homeostasis (GO:0070328)4.58297688
54acylglycerol homeostasis (GO:0055090)4.58297688
55* alpha-amino acid catabolic process (GO:1901606)4.57474244
56indolalkylamine metabolic process (GO:0006586)4.47698590
57cellular ketone body metabolic process (GO:0046950)4.44759101
58homocysteine metabolic process (GO:0050667)4.43774897
59amino-acid betaine metabolic process (GO:0006577)4.43696269
60negative regulation of sterol transport (GO:0032372)4.42527485
61negative regulation of cholesterol transport (GO:0032375)4.42527485
62aldehyde catabolic process (GO:0046185)4.41840739
63imidazole-containing compound metabolic process (GO:0052803)4.41032603
64negative regulation of protein activation cascade (GO:2000258)4.40832225
65coenzyme catabolic process (GO:0009109)4.40534680
66positive regulation of fatty acid biosynthetic process (GO:0045723)4.37472614
67ethanol metabolic process (GO:0006067)4.34344459
68plasma lipoprotein particle clearance (GO:0034381)4.33883781
69regulation of humoral immune response (GO:0002920)4.31582392
70glycine metabolic process (GO:0006544)4.31296420
71cholesterol efflux (GO:0033344)4.30754031
72serine family amino acid metabolic process (GO:0009069)4.20713684
73negative regulation of coagulation (GO:0050819)4.19174222
74serine family amino acid biosynthetic process (GO:0009070)4.18959720
75* cellular amino acid catabolic process (GO:0009063)4.18381804
76blood coagulation, intrinsic pathway (GO:0007597)4.17553225
77bile acid and bile salt transport (GO:0015721)4.14711174
78positive regulation of blood coagulation (GO:0030194)4.12923835
79positive regulation of hemostasis (GO:1900048)4.12923835
80regulation of apoptotic cell clearance (GO:2000425)4.11241568
81lysine catabolic process (GO:0006554)4.09575250
82lysine metabolic process (GO:0006553)4.09575250
83negative regulation of wound healing (GO:0061045)4.07740626
84benzene-containing compound metabolic process (GO:0042537)4.05489302
85fibrinolysis (GO:0042730)4.04550879
86arginine metabolic process (GO:0006525)4.03143788
87oxidative demethylation (GO:0070989)4.02308326
88NAD biosynthetic process (GO:0009435)4.01921676
89low-density lipoprotein particle remodeling (GO:0034374)4.01661400
90cellular glucuronidation (GO:0052695)4.00794586
91* glutamate metabolic process (GO:0006536)4.00558513
92heme transport (GO:0015886)3.97874340
93cofactor catabolic process (GO:0051187)3.95347596
94positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.94628870
95plasma lipoprotein particle assembly (GO:0034377)3.93603879
96positive regulation of lipoprotein lipase activity (GO:0051006)3.92731561
97positive regulation of triglyceride lipase activity (GO:0061365)3.92731561
98drug catabolic process (GO:0042737)3.89354351
99phenylpropanoid metabolic process (GO:0009698)3.89137145
100cellular modified amino acid catabolic process (GO:0042219)3.85894393
101ketone body metabolic process (GO:1902224)3.85204666
102negative regulation of lipase activity (GO:0060192)3.84893494
103nicotinamide nucleotide biosynthetic process (GO:0019359)3.80860469
104pyridine nucleotide biosynthetic process (GO:0019363)3.80860469
105lipoprotein metabolic process (GO:0042157)3.80571897
106ethanol oxidation (GO:0006069)3.79644053
107very-low-density lipoprotein particle assembly (GO:0034379)3.79009859
108positive regulation of coagulation (GO:0050820)3.78150009
109regulation of bile acid biosynthetic process (GO:0070857)3.77774010
110cholesterol homeostasis (GO:0042632)3.76103613
111cytolysis (GO:0019835)3.75765357
112opsonization (GO:0008228)3.75727143
113flavonoid metabolic process (GO:0009812)3.75398905
114* organic acid catabolic process (GO:0016054)3.70152840
115* carboxylic acid catabolic process (GO:0046395)3.70152840
116sterol homeostasis (GO:0055092)3.68553646
117uronic acid metabolic process (GO:0006063)3.66658143
118glucuronate metabolic process (GO:0019585)3.66658143
119short-chain fatty acid metabolic process (GO:0046459)3.65978744
120positive regulation of lipid catabolic process (GO:0050996)3.65326724
121cholesterol transport (GO:0030301)3.65074837
122sterol transport (GO:0015918)3.65074837
123protein activation cascade (GO:0072376)3.63012533
124plasma lipoprotein particle organization (GO:0071827)3.60110149
125acetyl-CoA metabolic process (GO:0006084)3.59806774
126regulation of lipoprotein particle clearance (GO:0010984)3.57960597
127dicarboxylic acid biosynthetic process (GO:0043650)3.56621562
128negative regulation of complement activation (GO:0045916)3.55453059
129acute inflammatory response (GO:0002526)3.54280501
130response to nitrosative stress (GO:0051409)3.49047269
131very long-chain fatty acid metabolic process (GO:0000038)3.48167730
132complement activation, classical pathway (GO:0006958)3.47295558
133complement activation (GO:0006956)3.44620100

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.86897613
2* EGR1_23403033_ChIP-Seq_LIVER_Mouse7.15386914
3PPARA_22158963_ChIP-Seq_LIVER_Mouse6.58746386
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.09266109
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.29192930
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.21585641
7CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.20170354
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.00281248
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.53590210
10HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.09799080
11ESR1_15608294_ChIP-ChIP_MCF-7_Human2.06923077
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.01407866
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.4477659
14HTT_18923047_ChIP-ChIP_STHdh_Human1.96213450
15TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.72123980
16CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.51222881
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.37417294
18LXR_22292898_ChIP-Seq_THP-1_Human1.34060399
19TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33300284
20TAF15_26573619_Chip-Seq_HEK293_Human1.31929085
21PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.30552248
22FOXA2_19822575_ChIP-Seq_HepG2_Human1.28966391
23* HNF4A_19822575_ChIP-Seq_HepG2_Human1.24456456
24STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.17311570
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.16915602
26* KAP1_22055183_ChIP-Seq_ESCs_Mouse1.14823032
27RXRA_24833708_ChIP-Seq_LIVER_Mouse1.11589574
28ZNF263_19887448_ChIP-Seq_K562_Human1.10145384
29CDX2_20551321_ChIP-Seq_CACO-2_Human1.07350511
30RARG_19884340_ChIP-ChIP_MEFs_Mouse1.05526220
31ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05071461
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.98305843
33STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.97517284
34TRIM28_21343339_ChIP-Seq_HEK293_Human0.95978403
35SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95340309
36ESR2_21235772_ChIP-Seq_MCF-7_Human0.94560053
37AUTS2_25519132_ChIP-Seq_293T-REX_Human0.94151257
38PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.93857464
39TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.93544625
40ESR1_20079471_ChIP-ChIP_T-47D_Human0.93326383
41GATA6_25053715_ChIP-Seq_YYC3_Human0.91998636
42IRF1_19129219_ChIP-ChIP_H3396_Human0.91869095
43THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.91426960
44NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.86624184
45RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.85870577
46GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.84564196
47PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.83992994
48TCF4_18268006_ChIP-ChIP_LS174T_Human0.83227582
49DNAJC2_21179169_ChIP-ChIP_NT2_Human0.82362376
50SMC4_20622854_ChIP-Seq_HELA_Human0.81907615
51PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.80530679
52GATA1_22025678_ChIP-Seq_K562_Human0.79573096
53* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.78771938
54RAC3_21632823_ChIP-Seq_H3396_Human0.77977778
55STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.76598932
56SOX2_21211035_ChIP-Seq_LN229_Human0.74173426
57ELF1_20517297_ChIP-Seq_JURKAT_Human0.72668126
58EGR1_19032775_ChIP-ChIP_M12_Human0.72475966
59KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.72046081
60SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.72014720
61NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.71530267
62NRF2_20460467_ChIP-Seq_MEFs_Mouse0.71530267
63CTCF_27219007_Chip-Seq_Bcells_Human0.71367560
64SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.71307234
65ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.71143240
66E2F1_20622854_ChIP-Seq_HELA_Human0.71100980
67NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.70602285
68P68_20966046_ChIP-Seq_HELA_Human0.69544170
69BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.69083645
70* POU5F1_16518401_ChIP-PET_MESCs_Mouse0.68161662
71CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.68050051
72CLOCK_20551151_ChIP-Seq_293T_Human0.67671078
73GATA1_19941827_ChIP-Seq_MEL_Mouse0.66145756
74AR_20517297_ChIP-Seq_VCAP_Human0.65627983
75CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.65533833
76* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.65018577
77RARA_24833708_ChIP-Seq_LIVER_Mouse0.64484648
78SOX2_20726797_ChIP-Seq_SW620_Human0.64112726
79GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.63765176
80RUNX1_27457419_Chip-Seq_LIVER_Mouse0.63683695
81SRY_22984422_ChIP-ChIP_TESTIS_Rat0.63394896
82SUZ12_27294783_Chip-Seq_NPCs_Mouse0.63373960
83STAT1_17558387_ChIP-Seq_HELA_Human0.63290389
84FOXO3_23340844_ChIP-Seq_DLD1_Human0.63231589
85BCOR_27268052_Chip-Seq_Bcells_Human0.63022263
86NFE2_27457419_Chip-Seq_LIVER_Mouse0.62535202
87TET1_21451524_ChIP-Seq_MESCs_Mouse0.62404889
88EZH2_27294783_Chip-Seq_NPCs_Mouse0.62087292
89NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.61410659
90EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.61019142
91SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.60352904
92VDR_22108803_ChIP-Seq_LS180_Human0.59956040
93RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.59811976
94SOX11_22085726_ChIP-Seq_ESNs_Mouse0.59316306
95CRX_20693478_ChIP-Seq_RETINA_Mouse0.59231945
96GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.59057318
97CSB_26484114_Chip-Seq_FIBROBLAST_Human0.58994625
98PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.58792642
99GATA4_25053715_ChIP-Seq_YYC3_Human0.58515458
100* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.57282496
101CEBPB_22108803_ChIP-Seq_LS180_Human0.56987458
102* MYC_19915707_ChIP-ChIP_AK7_Human0.56911712
103CBP_21632823_ChIP-Seq_H3396_Human0.56789903
104NCOR_22424771_ChIP-Seq_293T_Human0.56719790
105SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.56410989
106ZFP57_27257070_Chip-Seq_ESCs_Mouse0.56134690
107SOX2_27498859_Chip-Seq_STOMACH_Mouse0.55608365
108SMAD1_18555785_Chip-Seq_ESCs_Mouse0.55159887
109BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.55089239
110* SA1_27219007_Chip-Seq_Bcells_Human0.54654480
111ESET_19884257_ChIP-Seq_ESCs_Mouse0.54275416
112FOXA1_25552417_ChIP-Seq_VCAP_Human0.54098959
113PHF8_20622854_ChIP-Seq_HELA_Human0.54095883
114SPI1_20517297_ChIP-Seq_HL60_Human0.53931368
115SPI1_26923725_Chip-Seq_HPCs_Mouse0.53792446
116GBX2_23144817_ChIP-Seq_PC3_Human0.53733434
117GATA3_21867929_ChIP-Seq_CD8_Mouse0.53173285
118RARB_24833708_ChIP-Seq_LIVER_Mouse0.52741860
119TAF2_19829295_ChIP-Seq_ESCs_Human0.52659779
120P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.52605233
121P53_21459846_ChIP-Seq_SAOS-2_Human0.52574671
122OCT4_21477851_ChIP-Seq_ESCs_Mouse0.52470774
123CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.52282248
124EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.51864244
125ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.51725519
126EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.51691762
127TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.51331663
128CTCF_20526341_ChIP-Seq_ESCs_Human0.51280535
129SRF_21415370_ChIP-Seq_HL-1_Mouse0.51266360
130SOX2_22085726_ChIP-Seq_NPCs_Mouse0.51143734
131FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.50964424
132RACK7_27058665_Chip-Seq_MCF-7_Human0.50566367
133FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.50400445
134AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.49952937
135FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.49849549
136ETV2_25802403_ChIP-Seq_MESCs_Mouse0.49419788
137GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.49200511
138FOXH1_21741376_ChIP-Seq_EPCs_Human0.48978069
139CTBP1_25329375_ChIP-Seq_LNCAP_Human0.48657598
140SALL4_18804426_ChIP-ChIP_XEN_Mouse0.47942593
141PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.47439498
142PIAS1_25552417_ChIP-Seq_VCAP_Human0.46911917
143SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.46041822
144ERG_20517297_ChIP-Seq_VCAP_Human0.45639834
145SOX2_19829295_ChIP-Seq_ESCs_Human0.43861006
146NANOG_19829295_ChIP-Seq_ESCs_Human0.43861006
147ERG_21242973_ChIP-ChIP_JURKAT_Human0.43314854
148TAL1_26923725_Chip-Seq_HPCs_Mouse0.43233037
149OCT4_20526341_ChIP-Seq_ESCs_Human0.42610828
150IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.42591829
151ESRRB_18555785_Chip-Seq_ESCs_Mouse0.42561975
152PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.42378096
153GATA3_21867929_ChIP-Seq_TH1_Mouse0.41842122
154* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.41820778

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.22618174
2MP0005360_urolithiasis7.31588443
3MP0005085_abnormal_gallbladder_physiolo6.27841054
4MP0005365_abnormal_bile_salt5.88516556
5MP0008875_abnormal_xenobiotic_pharmacok5.14504247
6MP0003806_abnormal_nucleotide_metabolis4.31944255
7MP0003252_abnormal_bile_duct3.59130945
8MP0010329_abnormal_lipoprotein_level3.42427167
9MP0003195_calcinosis3.37795210
10MP0009840_abnormal_foam_cell3.22491518
11MP0005332_abnormal_amino_acid2.97473990
12MP0005083_abnormal_biliary_tract2.82128824
13MP0001666_abnormal_nutrient_absorption2.49329012
14MP0004019_abnormal_vitamin_homeostasis2.34889924
15MP0003191_abnormal_cellular_cholesterol2.08576935
16MP0002118_abnormal_lipid_homeostasis2.04411313
17MP0000609_abnormal_liver_physiology1.97259912
18MP0005451_abnormal_body_composition1.87222099
19MP0002138_abnormal_hepatobiliary_system1.86605391
20MP0003868_abnormal_feces_composition1.76371470
21MP0001764_abnormal_homeostasis1.75909400
22MP0009697_abnormal_copulation1.69730429
23MP0005319_abnormal_enzyme/_coenzyme1.64831777
24MP0003011_delayed_dark_adaptation1.62866347
25MP0005584_abnormal_enzyme/coenzyme_acti1.51889363
26MP0003186_abnormal_redox_activity1.48775381
27MP0003122_maternal_imprinting1.47346602
28MP0005408_hypopigmentation1.25219239
29MP0009643_abnormal_urine_homeostasis1.24334270
30MP0002089_abnormal_postnatal_growth/wei1.23549852
31MP0002876_abnormal_thyroid_physiology1.19546769
32MP0003656_abnormal_erythrocyte_physiolo1.17098405
33MP0001915_intracranial_hemorrhage1.14129482
34MP0005647_abnormal_sex_gland1.12995989
35MP0004381_abnormal_hair_follicle1.12251463
36MP0005636_abnormal_mineral_homeostasis1.09374787
37MP0000604_amyloidosis1.09132438
38MP0009764_decreased_sensitivity_to1.08452735
39MP0003172_abnormal_lysosome_physiology1.06926500
40MP0005058_abnormal_lysosome_morphology1.06383604
41MP0003718_maternal_effect1.05462213
42MP0005084_abnormal_gallbladder_morpholo0.99104841
43MP0000598_abnormal_liver_morphology0.97909934
44MP0009763_increased_sensitivity_to0.95739079
45MP0003879_abnormal_hair_cell0.93825961
46MP0001661_extended_life_span0.93686588
47MP0006036_abnormal_mitochondrial_physio0.92178010
48MP0009765_abnormal_xenobiotic_induced0.89168155
49MP0003690_abnormal_glial_cell0.89097213
50MP0009379_abnormal_foot_pigmentation0.85673612
51MP0008469_abnormal_protein_level0.85338559
52MP0009642_abnormal_blood_homeostasis0.84862462
53MP0005376_homeostasis/metabolism_phenot0.84380735
54MP0003329_amyloid_beta_deposits0.84362539
55MP0002254_reproductive_system_inflammat0.79360818
56MP0005535_abnormal_body_temperature0.75725229
57MP0005395_other_phenotype0.72433971
58MP0005670_abnormal_white_adipose0.72358636
59MP0006035_abnormal_mitochondrial_morpho0.71340338
60MP0002822_catalepsy0.67670087
61MP0010368_abnormal_lymphatic_system0.67122688
62MP0000566_synostosis0.66949968
63MP0005167_abnormal_blood-brain_barrier0.65482940
64MP0002078_abnormal_glucose_homeostasis0.65336933
65MP0003123_paternal_imprinting0.63438062
66MP0005266_abnormal_metabolism0.62971050
67MP0000639_abnormal_adrenal_gland0.61595697
68MP0002971_abnormal_brown_adipose0.61368583
69MP0003638_abnormal_response/metabolism_0.60517159
70MP0002282_abnormal_trachea_morphology0.59765058
71MP0001756_abnormal_urination0.59187267
72MP0005220_abnormal_exocrine_pancreas0.58624853
73MP0003724_increased_susceptibility_to0.58586740
74MP0005334_abnormal_fat_pad0.56358623
75MP0008872_abnormal_physiological_respon0.56009138
76MP0002249_abnormal_larynx_morphology0.52818785
77MP0004142_abnormal_muscle_tone0.49321183
78MP0006276_abnormal_autonomic_nervous0.48664957
79MP0002132_abnormal_respiratory_system0.48367218
80MP0004782_abnormal_surfactant_physiolog0.47930370
81MP0009780_abnormal_chondrocyte_physiolo0.45983232
82MP0000920_abnormal_myelination0.45815012
83MP0002136_abnormal_kidney_physiology0.45107951
84MP0008873_increased_physiological_sensi0.44586281
85MP0005448_abnormal_energy_balance0.43547771
86MP0009115_abnormal_fat_cell0.42858461
87MP0008874_decreased_physiological_sensi0.41687304
88MP0003183_abnormal_peptide_metabolism0.41661116
89MP0005379_endocrine/exocrine_gland_phen0.40275848
90MP0005377_hearing/vestibular/ear_phenot0.40211710
91MP0003878_abnormal_ear_physiology0.40211710
92MP0004883_abnormal_blood_vessel0.40100001
93MP0000230_abnormal_systemic_arterial0.39637589
94MP0004043_abnormal_pH_regulation0.39211909
95MP0004272_abnormal_basement_membrane0.39062228
96MP0005464_abnormal_platelet_physiology0.38905216
97MP0002796_impaired_skin_barrier0.38826173
98MP0006082_CNS_inflammation0.36820065
99MP0000579_abnormal_nail_morphology0.36758974
100MP0003953_abnormal_hormone_level0.36720089
101MP0005551_abnormal_eye_electrophysiolog0.36485545
102MP0002909_abnormal_adrenal_gland0.36104903
103MP0002837_dystrophic_cardiac_calcinosis0.35623448
104MP0005187_abnormal_penis_morphology0.35496888
105MP0005075_abnormal_melanosome_morpholog0.34795325
106MP0003075_altered_response_to0.33953159
107MP0005409_darkened_coat_color0.33788351
108MP0005023_abnormal_wound_healing0.32812126
109MP0002970_abnormal_white_adipose0.32525991
110MP0005164_abnormal_response_to0.32091962
111MP0001944_abnormal_pancreas_morphology0.31913681
112MP0009053_abnormal_anal_canal0.31879647
113MP0006292_abnormal_olfactory_placode0.31067515
114MP0001905_abnormal_dopamine_level0.30535347
115MP0003943_abnormal_hepatobiliary_system0.30389362
116MP0003567_abnormal_fetal_cardiomyocyte0.29950968
117MP0002168_other_aberrant_phenotype0.28736092
118MP0005595_abnormal_vascular_smooth0.28160230
119MP0001853_heart_inflammation0.27464692
120MP0004130_abnormal_muscle_cell0.27323521
121MP0004147_increased_porphyrin_level0.26902397
122MP0002295_abnormal_pulmonary_circulatio0.26690302
123MP0005666_abnormal_adipose_tissue0.26207399
124MP0002928_abnormal_bile_duct0.25670617
125MP0000371_diluted_coat_color0.25373377
126MP0000647_abnormal_sebaceous_gland0.25037959
127MP0000249_abnormal_blood_vessel0.24817266
128MP0003115_abnormal_respiratory_system0.24629731
129MP0003632_abnormal_nervous_system0.24450248
130MP0001529_abnormal_vocalization0.24020453

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.30358342
2Intrahepatic cholestasis (HP:0001406)6.93568146
3Prolonged partial thromboplastin time (HP:0003645)6.66966371
4Deep venous thrombosis (HP:0002625)6.66801220
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.26861981
6Hypobetalipoproteinemia (HP:0003563)6.02639238
7Xanthomatosis (HP:0000991)5.91102133
8Hyperlipoproteinemia (HP:0010980)5.51753241
9Joint hemorrhage (HP:0005261)4.76932216
10Complement deficiency (HP:0004431)4.56948287
11Hypolipoproteinemia (HP:0010981)4.45740119
12Hyperglycinemia (HP:0002154)4.36842131
13Abnormality of methionine metabolism (HP:0010901)4.32322464
14Hyperammonemia (HP:0001987)4.28417864
15Abnormality of the common coagulation pathway (HP:0010990)4.14689372
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.13655572
17Abnormality of aspartate family amino acid metabolism (HP:0010899)4.13410069
18Epidermoid cyst (HP:0200040)3.99589246
19Abnormality of sulfur amino acid metabolism (HP:0004339)3.96771115
20Abnormality of serine family amino acid metabolism (HP:0010894)3.95006072
21Abnormality of glycine metabolism (HP:0010895)3.95006072
22Hyperglycinuria (HP:0003108)3.94115064
23Fat malabsorption (HP:0002630)3.93248161
24Hypoalphalipoproteinemia (HP:0003233)3.88241384
25Ketosis (HP:0001946)3.88196484
26Conjugated hyperbilirubinemia (HP:0002908)3.86670054
27Abnormality of pyrimidine metabolism (HP:0004353)3.84645629
28Abnormality of glutamine family amino acid metabolism (HP:0010902)3.82084837
29Hypoglycemic coma (HP:0001325)3.46001573
30Nephritis (HP:0000123)3.28871793
31Hypercholesterolemia (HP:0003124)3.28272225
32Abnormality of complement system (HP:0005339)3.25896980
33Abnormality of the intrinsic pathway (HP:0010989)3.23741094
34Abnormality of fatty-acid metabolism (HP:0004359)3.20672394
35Spontaneous abortion (HP:0005268)3.18239021
36Hyperbilirubinemia (HP:0002904)3.15996873
37Delayed CNS myelination (HP:0002188)3.13379561
38Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.11474264
39Steatorrhea (HP:0002570)3.08775744
40Abnormality of serum amino acid levels (HP:0003112)3.07238112
41Cerebral edema (HP:0002181)3.06109251
42Hypochromic microcytic anemia (HP:0004840)2.98283166
43Lethargy (HP:0001254)2.94704100
44Abnormality of nucleobase metabolism (HP:0010932)2.91969639
45Purpura (HP:0000979)2.91898843
46Metabolic acidosis (HP:0001942)2.72754658
47Dicarboxylic aciduria (HP:0003215)2.64181378
48Abnormality of dicarboxylic acid metabolism (HP:0010995)2.64181378
49Ketoacidosis (HP:0001993)2.62219710
50Vascular calcification (HP:0004934)2.60495243
51Hepatocellular carcinoma (HP:0001402)2.54353437
52Abnormality of purine metabolism (HP:0004352)2.45631644
53Amyloidosis (HP:0011034)2.44468793
54Myocardial infarction (HP:0001658)2.43836735
55Gout (HP:0001997)2.38574950
56Irritability (HP:0000737)2.37006500
57Pulmonary embolism (HP:0002204)2.34556243
58Skin nodule (HP:0200036)2.34072559
59Osteomalacia (HP:0002749)2.33841894
60Brushfield spots (HP:0001088)2.32773706
61Hypophosphatemic rickets (HP:0004912)2.31932662
62Acanthocytosis (HP:0001927)2.29972039
63Systemic lupus erythematosus (HP:0002725)2.28559146
64Vomiting (HP:0002013)2.25761389
65Enlarged kidneys (HP:0000105)2.24672290
66Hypoglycemic seizures (HP:0002173)2.24043696
67Cardiovascular calcification (HP:0011915)2.23828969
68Abnormal gallbladder morphology (HP:0012437)2.23357833
69Malnutrition (HP:0004395)2.21777385
70Glomerulonephritis (HP:0000099)2.21632865
71Abnormality of urine glucose concentration (HP:0011016)2.20248954
72Glycosuria (HP:0003076)2.20248954
73Rickets (HP:0002748)2.18723146
74Abnormal gallbladder physiology (HP:0012438)2.17180071
75Cholecystitis (HP:0001082)2.17180071
76Proximal tubulopathy (HP:0000114)2.14301542
77Opisthotonus (HP:0002179)2.11897403
78Mitral stenosis (HP:0001718)2.11709167
79Pancreatitis (HP:0001733)2.11190180
80Abnormality of the Achilles tendon (HP:0005109)2.11142373
81Generalized aminoaciduria (HP:0002909)2.10733857
82Acute encephalopathy (HP:0006846)2.10519449
83Cholelithiasis (HP:0001081)2.09515083
84Renal cortical cysts (HP:0000803)2.08827363
85Hemorrhage of the eye (HP:0011885)2.08101256
86Alkalosis (HP:0001948)2.08083477
87Confusion (HP:0001289)2.07615235
88Potter facies (HP:0002009)2.04654037
89Facial shape deformation (HP:0011334)2.04654037
90Increased serum pyruvate (HP:0003542)2.01771248
91Menorrhagia (HP:0000132)1.99555934
92Neonatal onset (HP:0003623)1.95099585
93Abnormality of carpal bone ossification (HP:0006257)1.94269425
94Gingival bleeding (HP:0000225)1.93278373
95Arthropathy (HP:0003040)1.92877667
96Reduced antithrombin III activity (HP:0001976)1.92383525
97Abnormality of proline metabolism (HP:0010907)1.91053748
98Hydroxyprolinuria (HP:0003080)1.91053748
99Abnormal tarsal ossification (HP:0008369)1.89457489
100Hepatic necrosis (HP:0002605)1.89069794
101Elevated alkaline phosphatase (HP:0003155)1.87786029
102Hyperinsulinemic hypoglycemia (HP:0000825)1.86231686
103Abnormality of alkaline phosphatase activity (HP:0004379)1.85830764
104Abnormal enzyme/coenzyme activity (HP:0012379)1.85605479
105Hyperventilation (HP:0002883)1.84847876
106Fair hair (HP:0002286)1.84122829
107Hyperphosphaturia (HP:0003109)1.84079249
108Recurrent gram-negative bacterial infections (HP:0005420)1.81565723
109Sensorimotor neuropathy (HP:0007141)1.81563088
110Abnormality of vitamin metabolism (HP:0100508)1.81201790
111Abnormality of iron homeostasis (HP:0011031)1.81143329
112Elevated hepatic transaminases (HP:0002910)1.81074045
113Thrombophlebitis (HP:0004418)1.80937278
114Poikilocytosis (HP:0004447)1.80317156
115Bifid scrotum (HP:0000048)1.79297996
116Abnormality of transition element cation homeostasis (HP:0011030)1.79282521
117Abnormality of glycolysis (HP:0004366)1.78960323
118Renal Fanconi syndrome (HP:0001994)1.78769399
119Spastic paraparesis (HP:0002313)1.78329824
120Abnormality of the gallbladder (HP:0005264)1.77627755
121Epistaxis (HP:0000421)1.73478715
122Gangrene (HP:0100758)1.73110225
123Vaginal fistula (HP:0004320)1.67352663
124Widely patent fontanelles and sutures (HP:0004492)1.66420367
125Abnormal urine phosphate concentration (HP:0012599)1.65039659
126Retinal atrophy (HP:0001105)1.63956349
127Increased serum ferritin (HP:0003281)1.63584918
128Reticulocytosis (HP:0001923)1.62784840
129Joint swelling (HP:0001386)1.61453627
130Abnormal platelet function (HP:0011869)1.61329896
131Impaired platelet aggregation (HP:0003540)1.61329896

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.17095391
2FGFR33.90221511
3FGFR43.66135738
4IRAK33.41506312
5STK163.26273873
6ICK3.22404762
7INSRR2.93390282
8TRIB32.87787178
9SIK12.73123665
10RIPK12.63004705
11ERBB42.60396050
12DYRK1B2.48430993
13PBK2.36451690
14IRAK22.28379722
15TAOK32.22796632
16ABL21.99999842
17IRAK11.93239190
18CASK1.91602006
19PINK11.89941606
20CDK121.87492027
21MAP2K41.81417646
22PIK3CA1.76535692
23ERN11.76264348
24TYRO31.73774883
25OXSR11.70673307
26PDGFRA1.64117016
27EPHA41.63200541
28MAPK151.62365789
29MST1R1.61973764
30STK391.56276797
31KDR1.53912941
32EPHB11.48889147
33NTRK31.46238517
34PDK21.45267143
35PKN11.42790841
36PIK3CG1.41462924
37GRK11.41462383
38FGFR11.38854667
39PKN21.37314379
40MARK11.34010086
41IRAK41.31290852
42ZAK1.31236527
43CAMK2G1.27922247
44AKT31.23204842
45DAPK21.22297639
46MAPK111.18889922
47CSF1R1.17144317
48MAP2K31.17068763
49FGFR21.13168348
50MET1.12922624
51MAPK41.12368166
52RET1.11932259
53TIE11.10806812
54DDR21.09528603
55PDK11.08787846
56SIK21.08348656
57PLK41.04247280
58TYK21.01205887
59STK38L0.96915106
60PNCK0.95719391
61WNK10.94873311
62MAP3K140.93149728
63SGK20.92048277
64MAP3K110.91204147
65PRKAA10.91104212
66EEF2K0.89117162
67CSNK1G30.87284376
68SGK30.87088946
69PRKCZ0.86857651
70GRK60.85194090
71SGK10.84901560
72CDK60.84613879
73MAP3K20.82348815
74CAMK1G0.81875907
75MAPK70.81285338
76CSNK1G10.81098541
77CDK40.80684175
78ADRBK20.80662438
79CAMK2B0.80568193
80BMPR20.80129457
81WNK40.77821603
82BCR0.76575729
83PRKCQ0.76010155
84PRKCG0.74392303
85PRKAA20.74216260
86CDK70.70969692
87BLK0.66782894
88TGFBR20.66664779
89GRK70.66110897
90MAP3K10.65696649
91IGF1R0.65298862
92ERBB20.62987180
93PRKACG0.61803939
94CSNK1G20.60271565
95MAPK120.60048895
96CSNK1A1L0.56345264
97BUB10.55901919
98SMG10.55835003
99GSK3A0.55538324
100EPHA20.55268500
101MTOR0.54360700
102CAMK2D0.54213145
103SGK2230.53797438
104SGK4940.53797438
105CAMK2A0.53526581
106PTK60.53199161
107RPS6KB10.53190762
108WNK30.51501928
109CDC42BPA0.50175306
110BMPR1B0.49840038
111TLK10.49534214
112MATK0.49416300
113CAMK1D0.48451516
114PRKG10.48200161
115DYRK20.47707243
116EPHA30.47677018
117NEK90.46952005
118PTK20.46825344
119CSK0.45193516
120MAP3K70.44978124
121PRKACA0.44970126
122CSNK1D0.43924150
123JAK20.43208016
124MAP3K30.43186395
125TAOK20.43007167
126TNIK0.42309157
127BRAF0.42305871
128FGR0.42020478
129SRC0.40238743
130PRKCA0.39721355
131IKBKE0.39362130
132RPS6KA30.38711375
133CSNK2A20.36992124
134GRK50.36824516
135LATS10.36389079
136EIF2AK20.35165705
137MAP2K70.33464060
138TBK10.31896181
139NME20.30646740
140MAPK30.30479957
141NEK60.30393152
142LMTK20.30276813
143PDPK10.30015319
144PDGFRB0.28800206
145CDK90.28623315
146PRKCE0.28313524
147BMX0.27940332
148AKT20.27915928
149CSNK1E0.27736673
150MAPKAPK30.27169001
151MAP2K60.26713290
152NUAK10.26336202
153PRKCB0.25947037
154CSNK2A10.25776044
155PRKACB0.25555737
156EIF2AK10.24981034
157MAP2K20.24232520
158KSR20.22830382

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.31263386
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.11497100
3Nitrogen metabolism_Homo sapiens_hsa009103.04003868
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.96052258
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.82078819
6Arginine biosynthesis_Homo sapiens_hsa002202.81368616
7Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.74375965
8Complement and coagulation cascades_Homo sapiens_hsa046102.65961544
9Tryptophan metabolism_Homo sapiens_hsa003802.59230572
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.57688935
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.37147845
12Fatty acid degradation_Homo sapiens_hsa000712.31131602
13Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.27979671
14Peroxisome_Homo sapiens_hsa041462.21521792
15Butanoate metabolism_Homo sapiens_hsa006502.20508922
16Pentose and glucuronate interconversions_Homo sapiens_hsa000402.16217513
17Histidine metabolism_Homo sapiens_hsa003402.14192337
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.04209886
19Chemical carcinogenesis_Homo sapiens_hsa052042.01755521
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.97639550
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.95257835
22Fatty acid elongation_Homo sapiens_hsa000621.85764901
23Propanoate metabolism_Homo sapiens_hsa006401.85304937
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.83279343
25Retinol metabolism_Homo sapiens_hsa008301.80146589
26beta-Alanine metabolism_Homo sapiens_hsa004101.77230830
27Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.75447431
28Fatty acid metabolism_Homo sapiens_hsa012121.73134459
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.72914168
30PPAR signaling pathway_Homo sapiens_hsa033201.71434529
31Staphylococcus aureus infection_Homo sapiens_hsa051501.65633719
32Steroid biosynthesis_Homo sapiens_hsa001001.63913598
33Phenylalanine metabolism_Homo sapiens_hsa003601.62600703
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.59476590
35Tyrosine metabolism_Homo sapiens_hsa003501.56318681
36Sulfur metabolism_Homo sapiens_hsa009201.48520070
37Caffeine metabolism_Homo sapiens_hsa002321.48108812
38Selenocompound metabolism_Homo sapiens_hsa004501.38169542
39Folate biosynthesis_Homo sapiens_hsa007901.36202500
40Vitamin B6 metabolism_Homo sapiens_hsa007501.33653639
41Pyruvate metabolism_Homo sapiens_hsa006201.32858233
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.31036450
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.31025775
44Bile secretion_Homo sapiens_hsa049761.30915607
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.21050643
46ABC transporters_Homo sapiens_hsa020101.14965033
47Starch and sucrose metabolism_Homo sapiens_hsa005001.13739094
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.10333806
49Fat digestion and absorption_Homo sapiens_hsa049751.09950363
50Maturity onset diabetes of the young_Homo sapiens_hsa049501.08564627
51* Arginine and proline metabolism_Homo sapiens_hsa003301.08335695
52Cyanoamino acid metabolism_Homo sapiens_hsa004601.04501848
53Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.02966973
54Vitamin digestion and absorption_Homo sapiens_hsa049771.01049323
55Biosynthesis of amino acids_Homo sapiens_hsa012301.00902804
56Carbon metabolism_Homo sapiens_hsa012000.95667180
57Sulfur relay system_Homo sapiens_hsa041220.92127099
58Glutathione metabolism_Homo sapiens_hsa004800.88507702
59Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.87398100
60Other glycan degradation_Homo sapiens_hsa005110.74844505
61One carbon pool by folate_Homo sapiens_hsa006700.72832000
62Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.65340878
63* Metabolic pathways_Homo sapiens_hsa011000.64711061
64Glycerolipid metabolism_Homo sapiens_hsa005610.64546755
65Lysine degradation_Homo sapiens_hsa003100.57952858
66Glycosaminoglycan degradation_Homo sapiens_hsa005310.57747954
67Oxidative phosphorylation_Homo sapiens_hsa001900.54112228
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52461241
69Pentose phosphate pathway_Homo sapiens_hsa000300.51430898
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49723564
71Linoleic acid metabolism_Homo sapiens_hsa005910.49480941
72Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42709451
73Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.32957893
74Pertussis_Homo sapiens_hsa051330.32542811
75Fatty acid biosynthesis_Homo sapiens_hsa000610.30767218
76Parkinsons disease_Homo sapiens_hsa050120.29199749
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.26577388
78Prion diseases_Homo sapiens_hsa050200.25788481
79Alzheimers disease_Homo sapiens_hsa050100.17984666
80Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.17449447
81Ether lipid metabolism_Homo sapiens_hsa005650.15157213
82Fructose and mannose metabolism_Homo sapiens_hsa000510.15116870
83Arachidonic acid metabolism_Homo sapiens_hsa005900.14028684
84Galactose metabolism_Homo sapiens_hsa000520.13962234
85Protein export_Homo sapiens_hsa030600.13675025
86Sphingolipid metabolism_Homo sapiens_hsa006000.13101123
87Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.12629839
88N-Glycan biosynthesis_Homo sapiens_hsa005100.09051407
89Huntingtons disease_Homo sapiens_hsa050160.05171077
90Thyroid hormone synthesis_Homo sapiens_hsa049180.04558686
91Pyrimidine metabolism_Homo sapiens_hsa002400.04295945
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.02181679
93Proteasome_Homo sapiens_hsa030500.01744978
94AMPK signaling pathway_Homo sapiens_hsa04152-0.2020780
95Type II diabetes mellitus_Homo sapiens_hsa04930-0.1944873
96Mineral absorption_Homo sapiens_hsa04978-0.1932262
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080-0.1927659
98Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1912288
99Other types of O-glycan biosynthesis_Homo sapiens_hsa00514-0.1761832
100Renin-angiotensin system_Homo sapiens_hsa04614-0.1701178
101Purine metabolism_Homo sapiens_hsa00230-0.1681085
102Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1309018
103Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1198053
104Glucagon signaling pathway_Homo sapiens_hsa04922-0.1082492
105Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1061473
106Insulin resistance_Homo sapiens_hsa04931-0.0877983
107African trypanosomiasis_Homo sapiens_hsa05143-0.0821175
108Amoebiasis_Homo sapiens_hsa05146-0.0680457
109Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0456108
110Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0409982
111Insulin signaling pathway_Homo sapiens_hsa04910-0.0327335
112Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0207561
113Regulation of autophagy_Homo sapiens_hsa04140-0.0169612

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