PROK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene induces proliferation, migration, and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. It has little or no effect on a variety of other endothelial and non-endothelial cell types. Its expression is restricted to the steroidogenic glands (ovary, testis, adrenal, and placenta), is induced by hypoxia, and often complementary to the expression of vascular endothelial growth factor (VEGF), suggesting that these molecules function in a coordinated manner. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.54443037
2L-phenylalanine catabolic process (GO:0006559)7.54443037
3L-phenylalanine metabolic process (GO:0006558)7.17723064
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.17723064
5extracellular fibril organization (GO:0043206)7.15881169
6aromatic amino acid family catabolic process (GO:0009074)6.88386191
7glyoxylate metabolic process (GO:0046487)6.61946140
8collagen fibril organization (GO:0030199)6.50085108
9tryptophan catabolic process (GO:0006569)6.33769559
10indole-containing compound catabolic process (GO:0042436)6.33769559
11indolalkylamine catabolic process (GO:0046218)6.33769559
12kynurenine metabolic process (GO:0070189)6.17542458
13fibril organization (GO:0097435)6.00666139
14triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.99851360
15tryptophan metabolic process (GO:0006568)5.92129174
16bile acid biosynthetic process (GO:0006699)5.82641439
17cysteine metabolic process (GO:0006534)5.59262484
18negative regulation of fibrinolysis (GO:0051918)5.43345810
19high-density lipoprotein particle remodeling (GO:0034375)5.41778529
20regulation of fibrinolysis (GO:0051917)5.30976188
21alpha-linolenic acid metabolic process (GO:0036109)5.29647530
22protein carboxylation (GO:0018214)5.24612346
23peptidyl-glutamic acid carboxylation (GO:0017187)5.24612346
24serine family amino acid catabolic process (GO:0009071)5.23417733
25response to follicle-stimulating hormone (GO:0032354)5.19962146
26lysine catabolic process (GO:0006554)5.13715592
27lysine metabolic process (GO:0006553)5.13715592
28fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.13390078
29urea cycle (GO:0000050)5.09910778
30urea metabolic process (GO:0019627)5.09910778
31sulfur amino acid catabolic process (GO:0000098)5.06224488
32regulation of protein activation cascade (GO:2000257)5.03183535
33complement activation, alternative pathway (GO:0006957)4.98849785
34cellular ketone body metabolic process (GO:0046950)4.98390363
35aromatic amino acid family metabolic process (GO:0009072)4.97734060
36growth hormone secretion (GO:0030252)4.89885806
37bile acid metabolic process (GO:0008206)4.88381599
38amino-acid betaine metabolic process (GO:0006577)4.86538362
39urate metabolic process (GO:0046415)4.82893244
40reverse cholesterol transport (GO:0043691)4.79314510
41regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)4.79192581
42regulation of cholesterol esterification (GO:0010872)4.77869781
43positive regulation of Rho protein signal transduction (GO:0035025)4.75805699
44nitrogen cycle metabolic process (GO:0071941)4.72374196
45homocysteine metabolic process (GO:0050667)4.69606002
46regulation of complement activation (GO:0030449)4.69108810
47alpha-amino acid catabolic process (GO:1901606)4.61669254
48tyrosine metabolic process (GO:0006570)4.61307555
49protein-lipid complex remodeling (GO:0034368)4.61171977
50macromolecular complex remodeling (GO:0034367)4.61171977
51plasma lipoprotein particle remodeling (GO:0034369)4.61171977
52acylglycerol homeostasis (GO:0055090)4.50923462
53triglyceride homeostasis (GO:0070328)4.50923462
54drug transmembrane transport (GO:0006855)4.48522010
55indolalkylamine metabolic process (GO:0006586)4.47692529
56cell migration involved in heart development (GO:0060973)4.46756269
57glomerular visceral epithelial cell development (GO:0072015)4.41290082
58glutamate metabolic process (GO:0006536)4.39018640
59regulation of triglyceride catabolic process (GO:0010896)4.35479607
60phospholipid efflux (GO:0033700)4.34057414
61coenzyme catabolic process (GO:0009109)4.33417845
62glycine metabolic process (GO:0006544)4.32864016
63serine family amino acid metabolic process (GO:0009069)4.32200687
64amine catabolic process (GO:0009310)4.30695523
65cellular biogenic amine catabolic process (GO:0042402)4.30695523
66cellular amino acid catabolic process (GO:0009063)4.30560269
67ketone body metabolic process (GO:1902224)4.30483645
68cellular modified amino acid catabolic process (GO:0042219)4.26284639
69negative regulation of sterol transport (GO:0032372)4.25607866
70negative regulation of cholesterol transport (GO:0032375)4.25607866
71cellular zinc ion homeostasis (GO:0006882)4.14434521
72aldehyde catabolic process (GO:0046185)4.13934029
73plasma lipoprotein particle clearance (GO:0034381)4.13534398
74dicarboxylic acid biosynthetic process (GO:0043650)4.12762786
75keratan sulfate catabolic process (GO:0042340)4.11859064
76benzene-containing compound metabolic process (GO:0042537)4.11135714
77drug catabolic process (GO:0042737)4.10868298
78serine family amino acid biosynthetic process (GO:0009070)4.07595124
79positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)4.05812954
80bile acid and bile salt transport (GO:0015721)4.03049462
81cholesterol efflux (GO:0033344)4.01562945
82regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.97278456
83regulation of cardiac muscle hypertrophy (GO:0010611)3.96487509
84cellular glucuronidation (GO:0052695)3.94898543
85cell adhesion mediated by integrin (GO:0033627)3.94355264
86short-chain fatty acid metabolic process (GO:0046459)3.94149577
87glomerular epithelial cell development (GO:0072310)3.93454239
88fibrinolysis (GO:0042730)3.93409015
89dopamine transport (GO:0015872)3.92037376
90positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)3.91699070
91positive regulation of growth hormone secretion (GO:0060124)3.86256881
92imidazole-containing compound metabolic process (GO:0052803)3.82588942
93organic acid catabolic process (GO:0016054)3.82128884
94carboxylic acid catabolic process (GO:0046395)3.82128884
95regulation of muscle hypertrophy (GO:0014743)3.79943704
96aspartate family amino acid catabolic process (GO:0009068)3.78912076
97blood coagulation, intrinsic pathway (GO:0007597)3.77803433
982-oxoglutarate metabolic process (GO:0006103)3.75693813
99plasma lipoprotein particle assembly (GO:0034377)3.75434398
100arginine metabolic process (GO:0006525)3.75169700
101low-density lipoprotein particle remodeling (GO:0034374)3.74472853
102collagen metabolic process (GO:0032963)3.73253076
103phospholipid homeostasis (GO:0055091)3.72349543
104drug transport (GO:0015893)3.72249373
105acetyl-CoA metabolic process (GO:0006084)3.71265748
106bundle of His cell to Purkinje myocyte communication (GO:0086069)3.71246182
107exogenous drug catabolic process (GO:0042738)3.70597457
108lymphangiogenesis (GO:0001946)3.69630363
109ethanol oxidation (GO:0006069)3.69254476
110carnitine metabolic process (GO:0009437)3.69247745
111fatty acid oxidation (GO:0019395)3.66613236
112sperm motility (GO:0030317)3.65355411
113fatty acid beta-oxidation (GO:0006635)3.64458635
114retrograde transport, vesicle recycling within Golgi (GO:0000301)3.64260396
115chondrocyte development (GO:0002063)3.63819960
116monocarboxylic acid catabolic process (GO:0072329)3.62788734
117glucuronate metabolic process (GO:0019585)3.60693917
118uronic acid metabolic process (GO:0006063)3.60693917
119regulation of cholesterol homeostasis (GO:2000188)3.60496144
120lipid oxidation (GO:0034440)3.59434936
121positive regulation of lipoprotein lipase activity (GO:0051006)3.57869777
122positive regulation of triglyceride lipase activity (GO:0061365)3.57869777
123cholesterol homeostasis (GO:0042632)3.57060987
124multicellular organismal macromolecule metabolic process (GO:0044259)3.56908179
125cofactor catabolic process (GO:0051187)3.56575720
126catechol-containing compound biosynthetic process (GO:0009713)3.54794896
127catecholamine biosynthetic process (GO:0042423)3.54794896
128multicellular organismal metabolic process (GO:0044236)3.53568625
129cytolysis (GO:0019835)3.53471902
130sterol homeostasis (GO:0055092)3.52695788
131collagen catabolic process (GO:0030574)3.50849035
132astrocyte development (GO:0014002)3.48252250
133basement membrane organization (GO:0071711)3.46403457
134interleukin-1-mediated signaling pathway (GO:0070498)3.46337391
135cartilage morphogenesis (GO:0060536)3.39515176
136seminiferous tubule development (GO:0072520)3.38796049
137desmosome organization (GO:0002934)3.35812244
138endocardial cushion development (GO:0003197)3.33992460
139glycoprotein catabolic process (GO:0006516)3.33852554
140multicellular organismal catabolic process (GO:0044243)3.33503380
141ovulation from ovarian follicle (GO:0001542)3.30545535
142positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)3.28004746
143sequestering of extracellular ligand from receptor (GO:0035581)3.27968226
144pathway-restricted SMAD protein phosphorylation (GO:0060389)3.22975188
145organic cation transport (GO:0015695)3.21729061
146cardiac epithelial to mesenchymal transition (GO:0060317)3.21263695
147regulation of cardiac muscle cell differentiation (GO:2000725)3.18982384
148peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.15269753
149regulation of transforming growth factor beta2 production (GO:0032909)3.14834054
150protein targeting to Golgi (GO:0000042)3.14147494
151response to prostaglandin E (GO:0034695)3.13493668
152cardiac chamber formation (GO:0003207)3.13180394
153cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.12595393
154apoptotic cell clearance (GO:0043277)3.12135119
155protein retention in ER lumen (GO:0006621)3.08113367
156regulation of dopamine secretion (GO:0014059)3.06232502
157skin development (GO:0043588)3.01593739
158glial cell migration (GO:0008347)2.97941583
159microtubule depolymerization (GO:0007019)2.96641673
160interleukin-6-mediated signaling pathway (GO:0070102)2.95379867
161regulation of muscle adaptation (GO:0043502)2.93025162
162establishment of protein localization to Golgi (GO:0072600)2.91776316
163establishment of apical/basal cell polarity (GO:0035089)2.89282170
164extracellular matrix disassembly (GO:0022617)2.88434373
165fusion of sperm to egg plasma membrane (GO:0007342)2.87863053
166peptide cross-linking (GO:0018149)2.87569279
167glucocorticoid biosynthetic process (GO:0006704)2.86176868
168response to gonadotropin (GO:0034698)2.82160791
169homeostasis of number of cells within a tissue (GO:0048873)2.78841639
170phenol-containing compound catabolic process (GO:0019336)2.78771616
171toxin transport (GO:1901998)2.78606692
172positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.76826595
173regulation of cardioblast differentiation (GO:0051890)2.76161421
174acrosome reaction (GO:0007340)2.75517946
175wound healing, spreading of epidermal cells (GO:0035313)2.75362963
176zinc ion homeostasis (GO:0055069)2.75331410
177establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.74519728
178regulation of growth hormone secretion (GO:0060123)2.73580926
179vascular endothelial growth factor signaling pathway (GO:0038084)2.73194095
180peripheral nervous system axon ensheathment (GO:0032292)2.71580327
181myelination in peripheral nervous system (GO:0022011)2.71580327
182heart trabecula formation (GO:0060347)2.68397136
183blood vessel development (GO:0001568)2.68275749
184regulation of Rho protein signal transduction (GO:0035023)2.68258544
185negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.67851013
186protein localization to Golgi apparatus (GO:0034067)2.67698749
187folic acid transport (GO:0015884)2.67136196
188androgen biosynthetic process (GO:0006702)2.66749062
189peptidyl-proline hydroxylation (GO:0019511)2.62636162
190cellular response to gonadotropin stimulus (GO:0071371)2.62428338
191maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.60892100
192regulation of neuron migration (GO:2001222)2.60109093
193lung alveolus development (GO:0048286)2.59209752
194regulation of cardiac muscle tissue growth (GO:0055021)2.58758375
195cardiac ventricle formation (GO:0003211)2.58523182
196extracellular matrix assembly (GO:0085029)2.57410317
197mating behavior (GO:0007617)2.56308565
198definitive hemopoiesis (GO:0060216)2.53907501
199cardiac muscle tissue development (GO:0048738)2.53153746
200lung vasculature development (GO:0060426)2.53081835

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.22985110
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.99472461
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.63198347
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.34713832
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.02054068
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.65430910
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.61255112
8TRIM28_21343339_ChIP-Seq_HEK293_Human4.44673011
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.00799881
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.72484905
11GBX2_23144817_ChIP-Seq_PC3_Human3.42972327
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.32569480
13AR_21572438_ChIP-Seq_LNCaP_Human2.97840231
14BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.68038117
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.50120430
16MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.49519474
17EP300_21415370_ChIP-Seq_HL-1_Mouse2.30429004
18TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.10554415
19HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.08409463
20ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.7156166
21EZH2_22144423_ChIP-Seq_EOC_Human1.83167649
22TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82287646
23FOXA2_19822575_ChIP-Seq_HepG2_Human1.69814181
24SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.69652989
25DROSHA_22980978_ChIP-Seq_HELA_Human1.69442151
26SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.66240332
27* CJUN_26792858_Chip-Seq_BT549_Human1.63294294
28TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.60217109
29EZH2_18974828_ChIP-Seq_MESCs_Mouse1.58809376
30RNF2_18974828_ChIP-Seq_MESCs_Mouse1.58809376
31GATA1_22025678_ChIP-Seq_K562_Human1.55293304
32AHR_22903824_ChIP-Seq_MCF-7_Human1.50357359
33CDX2_19796622_ChIP-Seq_MESCs_Mouse1.49616653
34SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.46112493
35EED_16625203_ChIP-ChIP_MESCs_Mouse1.44099208
36NFIB_24661679_ChIP-Seq_LUNG_Mouse1.43828965
37MTF2_20144788_ChIP-Seq_MESCs_Mouse1.43277773
38HNF4A_19822575_ChIP-Seq_HepG2_Human1.42844275
39HTT_18923047_ChIP-ChIP_STHdh_Human1.42744687
40ARNT_22903824_ChIP-Seq_MCF-7_Human1.42495337
41SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.41994839
42TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40638191
43POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.40638191
44CLOCK_20551151_ChIP-Seq_293T_Human1.37053437
45SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31001046
46SMAD4_21741376_ChIP-Seq_EPCs_Human1.30705104
47ZNF217_24962896_ChIP-Seq_MCF-7_Human1.30651821
48EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.30116257
49SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.29980873
50TP53_18474530_ChIP-ChIP_U2OS_Human1.29657670
51RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.29425748
52EZH2_27294783_Chip-Seq_ESCs_Mouse1.28642906
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27854442
54PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.25410418
55EZH2_27304074_Chip-Seq_ESCs_Mouse1.24482024
56JARID2_20075857_ChIP-Seq_MESCs_Mouse1.23808416
57ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23542140
58THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.21543181
59SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.21487654
60CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.20593016
61RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.20354528
62IKZF1_21737484_ChIP-ChIP_HCT116_Human1.16966468
63RXRA_24833708_ChIP-Seq_LIVER_Mouse1.13201974
64SUZ12_27294783_Chip-Seq_ESCs_Mouse1.13031800
65SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.11741756
66SMAD4_21799915_ChIP-Seq_A2780_Human1.11676143
67ESR1_15608294_ChIP-ChIP_MCF-7_Human1.10003504
68HIF1A_21447827_ChIP-Seq_MCF-7_Human1.07054886
69SMAD3_21741376_ChIP-Seq_EPCs_Human1.06884290
70ISL1_27105846_Chip-Seq_CPCs_Mouse1.06325727
71SOX9_24532713_ChIP-Seq_HFSC_Mouse1.06223219
72* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.06093433
73CBP_20019798_ChIP-Seq_JUKART_Human1.05367795
74IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.05367795
75NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04776862
76SA1_22415368_ChIP-Seq_MEFs_Mouse1.04674002
77SMAD3_21741376_ChIP-Seq_HESCs_Human1.03599715
78TCF4_18268006_ChIP-ChIP_LS174T_Human1.00154110
79PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.99548099
80PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.99147700
81ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.97371678
82GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.95705199
83CTBP2_25329375_ChIP-Seq_LNCAP_Human0.93918871
84TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93080494
85JARID2_20064375_ChIP-Seq_MESCs_Mouse0.92847334
86BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92819845
87TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91826723
88WT1_19549856_ChIP-ChIP_CCG9911_Human0.89459041
89IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.89455780
90SOX2_27498859_Chip-Seq_STOMACH_Mouse0.89283084
91* TP63_22573176_ChIP-Seq_HFKS_Human0.88732289
92AUTS2_25519132_ChIP-Seq_293T-REX_Human0.88628835
93TP53_16413492_ChIP-PET_HCT116_Human0.88379753
94UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.87981087
95TET1_21490601_ChIP-Seq_MESCs_Mouse0.87238385
96FUS_26573619_Chip-Seq_HEK293_Human0.86430732
97AR_25329375_ChIP-Seq_VCAP_Human0.86100973
98TP63_23658742_ChIP-Seq_EP156T_Human0.85696949
99JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85661263
100CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.85442603
101BRD4_25478319_ChIP-Seq_HGPS_Human0.85191285
102TOP2B_26459242_ChIP-Seq_MCF-7_Human0.85175296
103FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.85148620
104ELK4_26923725_Chip-Seq_MESODERM_Mouse0.84090268
105RAC3_21632823_ChIP-Seq_H3396_Human0.83668417
106CTNNB1_20460455_ChIP-Seq_HCT116_Human0.83402284
107RING1B_27294783_Chip-Seq_NPCs_Mouse0.81895972
108GATA4_25053715_ChIP-Seq_YYC3_Human0.80917778
109RING1B_27294783_Chip-Seq_ESCs_Mouse0.80349867
110PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.79283010
111TAF15_26573619_Chip-Seq_HEK293_Human0.77892809
112ESR2_21235772_ChIP-Seq_MCF-7_Human0.77334667
113NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.76523399
114ESR1_21235772_ChIP-Seq_MCF-7_Human0.75375550
115AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.71787679
116KAP1_22055183_ChIP-Seq_ESCs_Mouse0.71470579
117ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.69313238
118SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.68876090
119RARG_19884340_ChIP-ChIP_MEFs_Mouse0.68277350
120* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.67904816
121EGR1_19032775_ChIP-ChIP_M12_Human0.65732866
122RARA_24833708_ChIP-Seq_LIVER_Mouse0.65652017
123TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.62876165
124BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.62829790
125NRF2_20460467_ChIP-Seq_MEFs_Mouse0.62603803
126NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.62603803
127SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.62125408
128MYC_19915707_ChIP-ChIP_AK7_Human0.61630925
129IRF8_22096565_ChIP-ChIP_GC-B_Human0.58924771
130CEBPB_22108803_ChIP-Seq_LS180_Human0.57746773
131NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.57442994
132FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.56826121
133ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.55369183
134Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.55297131
135ERG_21242973_ChIP-ChIP_JURKAT_Human0.55029581
136BCAT_22108803_ChIP-Seq_LS180_Human0.55021188
137LXR_22292898_ChIP-Seq_THP-1_Human0.54571412
138AR_20517297_ChIP-Seq_VCAP_Human0.54313298
139PIAS1_25552417_ChIP-Seq_VCAP_Human0.54255681
140PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.53811065
141RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.53783233
142CBP_21632823_ChIP-Seq_H3396_Human0.53197240
143FOXA1_25552417_ChIP-Seq_VCAP_Human0.53099575
144STAT1_17558387_ChIP-Seq_HELA_Human0.52687553
145CDX2_20551321_ChIP-Seq_CACO-2_Human0.52221021
146IRF1_19129219_ChIP-ChIP_H3396_Human0.51879480
147CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.51649601
148CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.50034573
149TAF2_19829295_ChIP-Seq_ESCs_Human0.49836154
150SALL4_18804426_ChIP-ChIP_XEN_Mouse0.47889015
151PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.47720859
152RARB_24833708_ChIP-Seq_LIVER_Mouse0.47417432
153STAT3_1855785_ChIP-Seq_MESCs_Mouse0.45137514
154SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.45101327
155ESET_19884257_ChIP-Seq_ESCs_Mouse0.44798692
156GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.44650253
157STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.44294012
158GATA2_19941826_ChIP-Seq_K562_Human0.43574251
159GATA1_19941826_ChIP-Seq_K562_Human0.43426446
160NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.42975354
161* GATA1_19941827_ChIP-Seq_MEL_Mouse0.42545588
162FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.42434292
163MYC_27129775_Chip-Seq_CORNEA_Mouse0.42293605
164ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.42206246
165SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.42105211
166CDX2_22108803_ChIP-Seq_LS180_Human0.41798925
167FOXO3_23340844_ChIP-Seq_DLD1_Human0.41364026
168P53_21459846_ChIP-Seq_SAOS-2_Human0.41170079
169ETV2_25802403_ChIP-Seq_MESCs_Mouse0.40689065
170FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.40489311
171AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.39591955
172EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.39325279
173SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.39303807
174SMAD4_21741376_ChIP-Seq_HESCs_Human0.39070821
175NCOR_22424771_ChIP-Seq_293T_Human0.38968025
176* CTCF_27219007_Chip-Seq_Bcells_Human0.38962764
177* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.38101874

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005275_abnormal_skin_tensile8.32407979
2MP0002139_abnormal_hepatobiliary_system8.26678808
3MP0005360_urolithiasis7.97513607
4MP0005085_abnormal_gallbladder_physiolo6.12304809
5MP0005365_abnormal_bile_salt5.90540956
6MP0005503_abnormal_tendon_morphology5.60789401
7MP0008875_abnormal_xenobiotic_pharmacok4.76516904
8MP0003252_abnormal_bile_duct3.82249300
9MP0003806_abnormal_nucleotide_metabolis3.77456567
10MP0004272_abnormal_basement_membrane3.47571849
11MP0010329_abnormal_lipoprotein_level3.43133031
12MP0001958_emphysema3.33952113
13MP0003195_calcinosis3.19912753
14MP0005332_abnormal_amino_acid3.11672878
15MP0009840_abnormal_foam_cell3.01722583
16MP0005083_abnormal_biliary_tract2.94675871
17MP0004019_abnormal_vitamin_homeostasis2.65742042
18MP0003191_abnormal_cellular_cholesterol2.52384184
19MP0001666_abnormal_nutrient_absorption2.43865206
20MP0002138_abnormal_hepatobiliary_system2.36959607
21MP0003279_aneurysm2.16001140
22MP0002060_abnormal_skin_morphology2.09596233
23MP0003122_maternal_imprinting2.07175023
24MP0000609_abnormal_liver_physiology2.05644327
25MP0002118_abnormal_lipid_homeostasis2.04675671
26MP0005410_abnormal_fertilization2.02048724
27MP0003567_abnormal_fetal_cardiomyocyte2.01955280
28MP0008438_abnormal_cutaneous_collagen10.9233769
29MP0004858_abnormal_nervous_system1.89402386
30MP0008004_abnormal_stomach_pH1.77879889
31MP0005319_abnormal_enzyme/_coenzyme1.77280249
32MP0003868_abnormal_feces_composition1.69618777
33MP0002108_abnormal_muscle_morphology1.67357199
34MP0001764_abnormal_homeostasis1.66496275
35MP0005171_absent_coat_pigmentation1.66174286
36MP0009643_abnormal_urine_homeostasis1.59843572
37MP0005584_abnormal_enzyme/coenzyme_acti1.59790909
38MP0003011_delayed_dark_adaptation1.48025315
39MP0005508_abnormal_skeleton_morphology1.47703529
40MP0010030_abnormal_orbit_morphology1.47545834
41MP0002295_abnormal_pulmonary_circulatio1.44546508
42MP0005451_abnormal_body_composition1.42470702
43MP0002282_abnormal_trachea_morphology1.36601709
44MP0005636_abnormal_mineral_homeostasis1.33158843
45MP0003385_abnormal_body_wall1.30865934
46MP0005647_abnormal_sex_gland1.24961640
47MP0003941_abnormal_skin_development1.24254588
48MP0003186_abnormal_redox_activity1.22115210
49MP0009697_abnormal_copulation1.21953989
50MP0001501_abnormal_sleep_pattern1.17985299
51MP0010386_abnormal_urinary_bladder1.15216620
52MP0001348_abnormal_lacrimal_gland1.11327351
53MP0005257_abnormal_intraocular_pressure1.11209265
54MP0002876_abnormal_thyroid_physiology1.08424099
55MP0000598_abnormal_liver_morphology1.07794785
56MP0003656_abnormal_erythrocyte_physiolo1.07313572
57MP0004043_abnormal_pH_regulation1.07229278
58MP0000604_amyloidosis1.07054239
59MP0005084_abnormal_gallbladder_morpholo1.04289605
60MP0005164_abnormal_response_to1.02774207
61MP0001879_abnormal_lymphatic_vessel1.01775500
62MP0009764_decreased_sensitivity_to0.99390172
63MP0000751_myopathy0.99301749
64MP0004264_abnormal_extraembryonic_tissu0.95125440
65MP0005409_darkened_coat_color0.94032915
66MP0001756_abnormal_urination0.90912869
67MP0009642_abnormal_blood_homeostasis0.90182039
68MP0002133_abnormal_respiratory_system0.89609496
69MP0005388_respiratory_system_phenotype0.89609496
70MP0003942_abnormal_urinary_system0.89456206
71MP0009763_increased_sensitivity_to0.88491333
72MP0005390_skeleton_phenotype0.86837130
73MP0006138_congestive_heart_failure0.85771534
74MP0010368_abnormal_lymphatic_system0.84928574
75MP0003300_gastrointestinal_ulcer0.84695624
76MP0008469_abnormal_protein_level0.84455913
77MP0002078_abnormal_glucose_homeostasis0.82839840
78MP0003115_abnormal_respiratory_system0.81545639
79MP0002254_reproductive_system_inflammat0.81384906
80MP0003705_abnormal_hypodermis_morpholog0.81282009
81MP0006036_abnormal_mitochondrial_physio0.81187655
82MP0005220_abnormal_exocrine_pancreas0.80831331
83MP0005535_abnormal_body_temperature0.80584735
84MP0005408_hypopigmentation0.79933056
85MP0000750_abnormal_muscle_regeneration0.79783233
86MP0003566_abnormal_cell_adhesion0.79157909
87MP0002896_abnormal_bone_mineralization0.78644580
88MP0002136_abnormal_kidney_physiology0.77537774
89MP0005376_homeostasis/metabolism_phenot0.75654756
90MP0002971_abnormal_brown_adipose0.73823018
91MP0001661_extended_life_span0.73540073
92MP0009765_abnormal_xenobiotic_induced0.73485053
93MP0005369_muscle_phenotype0.72489194
94MP0000462_abnormal_digestive_system0.72220170
95MP0003632_abnormal_nervous_system0.70422119
96MP0002106_abnormal_muscle_physiology0.68915487
97MP0001243_abnormal_dermal_layer0.68504956
98MP0001765_abnormal_ion_homeostasis0.68190710
99MP0001177_atelectasis0.67919470
100MP0000767_abnormal_smooth_muscle0.67683539
101MP0003698_abnormal_male_reproductive0.66644392
102MP0009780_abnormal_chondrocyte_physiolo0.66578267
103MP0003638_abnormal_response/metabolism_0.65857125
104MP0003329_amyloid_beta_deposits0.64462180
105MP0002928_abnormal_bile_duct0.64402828
106MP0000639_abnormal_adrenal_gland0.64401811
107MP0005377_hearing/vestibular/ear_phenot0.62205671
108MP0003878_abnormal_ear_physiology0.62205671
109MP0001614_abnormal_blood_vessel0.61615025
110MP0004130_abnormal_muscle_cell0.61313486
111MP0005670_abnormal_white_adipose0.61236758
112MP0002115_abnormal_skeleton_extremities0.61150316
113MP0000428_abnormal_craniofacial_morphol0.61094419
114MP0005334_abnormal_fat_pad0.60212138
115MP0003690_abnormal_glial_cell0.59768192
116MP0002998_abnormal_bone_remodeling0.59668117
117MP0003091_abnormal_cell_migration0.58100509
118MP0005395_other_phenotype0.57819568
119MP0004134_abnormal_chest_morphology0.55340012
120MP0004947_skin_inflammation0.54393404
121MP0005023_abnormal_wound_healing0.54319510
122MP0005448_abnormal_energy_balance0.54009423
123MP0005076_abnormal_cell_differentiation0.53785372
124MP0003879_abnormal_hair_cell0.53365017
125MP0005623_abnormal_meninges_morphology0.52872018
126MP0003718_maternal_effect0.52225699
127MP0001175_abnormal_lung_morphology0.52159807
128MP0005266_abnormal_metabolism0.52043417
129MP0002822_catalepsy0.50485351
130MP0010771_integument_phenotype0.50191232
131MP0009053_abnormal_anal_canal0.48772214
132MP0003950_abnormal_plasma_membrane0.48546367
133MP0005666_abnormal_adipose_tissue0.47843693
134MP0003953_abnormal_hormone_level0.47100343
135MP0000163_abnormal_cartilage_morphology0.47068916
136MP0000534_abnormal_ureter_morphology0.46853851
137MP0000230_abnormal_systemic_arterial0.46527547
138MP0000049_abnormal_middle_ear0.46364795
139MP0006035_abnormal_mitochondrial_morpho0.46119940
140MP0003724_increased_susceptibility_to0.46016787
141MP0002933_joint_inflammation0.45964419
142MP0008874_decreased_physiological_sensi0.45866549
143MP0002233_abnormal_nose_morphology0.45617082
144MP0002837_dystrophic_cardiac_calcinosis0.45458343
145MP0004381_abnormal_hair_follicle0.45449746
146MP0000538_abnormal_urinary_bladder0.45028907
147MP0004782_abnormal_surfactant_physiolog0.44661527
148MP0000566_synostosis0.44548499
149MP0009672_abnormal_birth_weight0.42775575
150MP0002796_impaired_skin_barrier0.42746044
151MP0009384_cardiac_valve_regurgitation0.42205075
152MP0003943_abnormal_hepatobiliary_system0.40413429
153MP0005464_abnormal_platelet_physiology0.40200963
154MP0000013_abnormal_adipose_tissue0.39893135
155MP0003075_altered_response_to0.39447959
156MP0003436_decreased_susceptibility_to0.38843061
157MP0002127_abnormal_cardiovascular_syste0.38749975
158MP0001929_abnormal_gametogenesis0.38619123
159MP0010630_abnormal_cardiac_muscle0.38489426
160MP0002932_abnormal_joint_morphology0.37893884
161MP0002102_abnormal_ear_morphology0.36486483
162MP0009250_abnormal_appendicular_skeleto0.36390539
163MP0004883_abnormal_blood_vessel0.35682511
164MP0005166_decreased_susceptibility_to0.35552256
165MP0002168_other_aberrant_phenotype0.34795187
166MP0008873_increased_physiological_sensi0.33952093
167MP0002135_abnormal_kidney_morphology0.33711611
168MP0009115_abnormal_fat_cell0.31610789
169MP0008872_abnormal_physiological_respon0.30599061
170MP0004147_increased_porphyrin_level0.29534708
171MP0005551_abnormal_eye_electrophysiolog0.29118145
172MP0005058_abnormal_lysosome_morphology0.28357344
173MP0001881_abnormal_mammary_gland0.27396212
174MP0003959_abnormal_lean_body0.27053519
175MP0001944_abnormal_pancreas_morphology0.26787417
176MP0000579_abnormal_nail_morphology0.26781512
177MP0005595_abnormal_vascular_smooth0.25359667
178MP0001845_abnormal_inflammatory_respons0.24554064
179MP0002970_abnormal_white_adipose0.24128812

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)8.86982179
2Aortic dissection (HP:0002647)7.52800141
3Intrahepatic cholestasis (HP:0001406)6.95854419
4Deep venous thrombosis (HP:0002625)6.86398967
5Abnormality of aromatic amino acid family metabolism (HP:0004338)6.80671792
6Protrusio acetabuli (HP:0003179)6.52464284
7Soft skin (HP:0000977)6.36182099
8Prolonged partial thromboplastin time (HP:0003645)6.22349821
9Xanthomatosis (HP:0000991)5.96906370
10Abnormality of monocarboxylic acid metabolism (HP:0010996)5.78699373
11Cerebral aneurysm (HP:0004944)5.58126834
12Atrophic scars (HP:0001075)5.54901746
13Hypobetalipoproteinemia (HP:0003563)5.35638009
14Bladder diverticulum (HP:0000015)5.35074816
15Fragile skin (HP:0001030)5.33209644
16Peritonitis (HP:0002586)5.00800532
17Complement deficiency (HP:0004431)4.98925418
18Hyperlipoproteinemia (HP:0010980)4.84287480
19Hyperglycinemia (HP:0002154)4.75091749
20Renovascular hypertension (HP:0100817)4.70970035
21Joint hemorrhage (HP:0005261)4.66661989
22Ketosis (HP:0001946)4.61684569
23Alopecia of scalp (HP:0002293)4.47767043
24Hyperammonemia (HP:0001987)4.44785807
25Hyperglycinuria (HP:0003108)4.43793125
26Aortic aneurysm (HP:0004942)4.41859181
27Abnormality of dentin (HP:0010299)4.39897687
28Abnormality of serine family amino acid metabolism (HP:0010894)4.35046144
29Abnormality of glycine metabolism (HP:0010895)4.35046144
30Hypolipoproteinemia (HP:0010981)4.31438818
31Abnormality of glutamine family amino acid metabolism (HP:0010902)4.30170279
32Abnormality of the common coagulation pathway (HP:0010990)4.29722412
33Abnormality of aspartate family amino acid metabolism (HP:0010899)4.15594335
34Striae distensae (HP:0001065)4.14986565
35Abnormal delivery (HP:0001787)4.12254681
36Abnormality of sulfur amino acid metabolism (HP:0004339)4.08311870
37Hypoalphalipoproteinemia (HP:0003233)4.06255021
38Dilatation of the ascending aorta (HP:0005111)4.05091474
39Blue sclerae (HP:0000592)3.99564510
40Delayed CNS myelination (HP:0002188)3.92537266
41Gout (HP:0001997)3.88535681
42Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.87639210
43Fat malabsorption (HP:0002630)3.86218031
44Hypoglycemic coma (HP:0001325)3.81861920
45Abnormality of methionine metabolism (HP:0010901)3.75588787
46Epidermoid cyst (HP:0200040)3.73602256
47Ketoacidosis (HP:0001993)3.64795497
48Abnormality of the intrinsic pathway (HP:0010989)3.59054163
49Conjugated hyperbilirubinemia (HP:0002908)3.59008680
50Abnormality of fatty-acid metabolism (HP:0004359)3.58140465
51Abnormality of complement system (HP:0005339)3.54257586
52Gastrointestinal infarctions (HP:0005244)3.47977142
53Mitral valve prolapse (HP:0001634)3.47623767
54Hyperextensible skin (HP:0000974)3.40815058
55Osteoarthritis (HP:0002758)3.39407680
56Osteolytic defects of the phalanges of the hand (HP:0009771)3.34966767
57Osteolytic defects of the hand bones (HP:0009699)3.34966767
58Abnormality of purine metabolism (HP:0004352)3.34343420
59Abnormality of nucleobase metabolism (HP:0010932)3.32136926
60Abnormality of pyrimidine metabolism (HP:0004353)3.27723938
61Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.26104962
62Osteomalacia (HP:0002749)3.21320461
63Vascular tortuosity (HP:0004948)3.17100881
64Hyperbilirubinemia (HP:0002904)3.16560723
65Hypercholesterolemia (HP:0003124)3.15298668
66Keratoconus (HP:0000563)3.12811537
67Increased corneal curvature (HP:0100692)3.12811537
68Shallow orbits (HP:0000586)3.08905076
69Abnormality of serum amino acid levels (HP:0003112)3.07536419
70Biconcave vertebral bodies (HP:0004586)3.04439174
71Hepatocellular carcinoma (HP:0001402)3.03103649
72Metabolic acidosis (HP:0001942)3.01236435
73Abnormality of the ischium (HP:0003174)2.97023327
74Vertebral compression fractures (HP:0002953)2.96203719
75Thin bony cortex (HP:0002753)2.94226061
76Vascular calcification (HP:0004934)2.93558864
77Fibular hypoplasia (HP:0003038)2.87802729
78Steatorrhea (HP:0002570)2.86839290
79Hypochromic microcytic anemia (HP:0004840)2.85333754
80Spontaneous abortion (HP:0005268)2.83936907
81Dicarboxylic aciduria (HP:0003215)2.82080786
82Abnormality of dicarboxylic acid metabolism (HP:0010995)2.82080786
83Aneurysm (HP:0002617)2.80970956
84Ectopia lentis (HP:0001083)2.78994927
85Narrow nasal bridge (HP:0000446)2.77378346
86Joint laxity (HP:0001388)2.73506120
87Genu recurvatum (HP:0002816)2.73132064
88Lethargy (HP:0001254)2.70640125
89Abnormality of the acetabulum (HP:0003170)2.70592311
90Venous insufficiency (HP:0005293)2.67833599
91Wormian bones (HP:0002645)2.64274819
92Enlarged kidneys (HP:0000105)2.62475112
93Hyperuricemia (HP:0002149)2.61623987
94Increased purine levels (HP:0004368)2.61623987
95Cardiovascular calcification (HP:0011915)2.59277194
96Neonatal onset (HP:0003623)2.55425123
97Generalized aminoaciduria (HP:0002909)2.52912954
98Thoracolumbar scoliosis (HP:0002944)2.52455301
99Proximal tubulopathy (HP:0000114)2.51015449
100Patent foramen ovale (HP:0001655)2.50502075
101Hypoglycemic seizures (HP:0002173)2.48195311
102Periodontitis (HP:0000704)2.47160496
103Systemic lupus erythematosus (HP:0002725)2.46194242
104Malnutrition (HP:0004395)2.44911497
105Broad metatarsal (HP:0001783)2.43176594
106Late onset (HP:0003584)2.41499084
107Cerebral edema (HP:0002181)2.41405021
108Myocardial infarction (HP:0001658)2.41181050
109Wide anterior fontanel (HP:0000260)2.39965178
110Irritability (HP:0000737)2.38257647
111Vitreoretinal degeneration (HP:0000655)2.36243593
112Arterial tortuosity (HP:0005116)2.35662438
113Hypoplasia of the iris (HP:0007676)2.35295454
114Alkalosis (HP:0001948)2.33423780
115Rickets (HP:0002748)2.32532803
116Venous abnormality (HP:0002624)2.31908726
117Broad ribs (HP:0000885)2.31463789
118Vomiting (HP:0002013)2.31012740
119Skin nodule (HP:0200036)2.29223640
120Sensorimotor neuropathy (HP:0007141)2.25668808
121Bowel diverticulosis (HP:0005222)2.25474192
122Spastic diplegia (HP:0001264)2.25339855
123Mitral stenosis (HP:0001718)2.24912038
124Glycosuria (HP:0003076)2.24769011
125Abnormality of urine glucose concentration (HP:0011016)2.24769011
126Pancreatitis (HP:0001733)2.21704703
127Abnormal gallbladder morphology (HP:0012437)2.21148336
128Right ventricular cardiomyopathy (HP:0011663)2.20958690
129Inguinal hernia (HP:0000023)2.20033089
130Cholelithiasis (HP:0001081)2.19653749
131Trismus (HP:0000211)2.19472896
132Sprengel anomaly (HP:0000912)2.19156000
133Amyloidosis (HP:0011034)2.14777200
134Glomerulonephritis (HP:0000099)2.13535391
135Hypophosphatemic rickets (HP:0004912)2.11509599
136Short tibia (HP:0005736)2.11330173
137Recurrent gram-negative bacterial infections (HP:0005420)2.09562302
138Acanthocytosis (HP:0001927)2.08722585
139Thin ribs (HP:0000883)2.07266420
140Abnormal gallbladder physiology (HP:0012438)2.07147701
141Cholecystitis (HP:0001082)2.07147701
142Menorrhagia (HP:0000132)2.06384049
143Opisthotonus (HP:0002179)2.05170694
144Gingival bleeding (HP:0000225)2.04761065
145Abnormal enzyme/coenzyme activity (HP:0012379)2.04511730
146Thrombophlebitis (HP:0004418)2.03785860
147Gingivitis (HP:0000230)2.03728747
148Hyperinsulinemic hypoglycemia (HP:0000825)2.02572369
149Redundant skin (HP:0001582)2.02001455
150Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.99048908
151Ulnar bowing (HP:0003031)1.97743143
152Breech presentation (HP:0001623)1.97676538
153Abnormality of proline metabolism (HP:0010907)1.97302793
154Hydroxyprolinuria (HP:0003080)1.97302793
155Thin skin (HP:0000963)1.95942972
156Esophageal varix (HP:0002040)1.95775034
157Nephrolithiasis (HP:0000787)1.94768141
158Bifid tongue (HP:0010297)1.94601192
159Short 5th finger (HP:0009237)1.94156774
160Tubulointerstitial nephritis (HP:0001970)1.93866197
161Abnormality of the aortic arch (HP:0012303)1.92505981
162Confusion (HP:0001289)1.90522252
163Multifactorial inheritance (HP:0001426)1.89774313
164Infantile muscular hypotonia (HP:0008947)1.89489703
165Brushfield spots (HP:0001088)1.87441723
166Hypoplastic ischia (HP:0003175)1.84667917
167Absent frontal sinuses (HP:0002688)1.83112276
168Asymmetric septal hypertrophy (HP:0001670)1.82739831
169Abnormality of the gallbladder (HP:0005264)1.82662426
170Hemorrhage of the eye (HP:0011885)1.82363909
171Short middle phalanx of the 5th finger (HP:0004220)1.82026013
172Abnormality of alkaline phosphatase activity (HP:0004379)1.81954355
173Elevated hepatic transaminases (HP:0002910)1.81635819
174Oligomenorrhea (HP:0000876)1.81068436
175Aplasia/Hypoplasia of the tibia (HP:0005772)1.80929719
176Neonatal short-limb short stature (HP:0008921)1.79630426
177Symptomatic seizures (HP:0011145)1.77554946
178Retinal atrophy (HP:0001105)1.74913869
179Aplasia/Hypoplasia of the fibula (HP:0006492)1.74822593
180Pulmonary artery stenosis (HP:0004415)1.74340412
181Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.73655745
182Aortic regurgitation (HP:0001659)1.70901545
183Abnormality of the peritoneum (HP:0002585)1.70801952
184Coxa vara (HP:0002812)1.69311350
185Chronic hepatic failure (HP:0100626)1.67222014
186Abnormality of the anterior chamber (HP:0000593)1.66377881
187Aplasia/Hypoplasia of the earlobes (HP:0009906)1.65236657
188Premature loss of primary teeth (HP:0006323)1.64255614
189Overgrowth (HP:0001548)1.64235026
190Follicular hyperkeratosis (HP:0007502)1.63421847
191Coronal craniosynostosis (HP:0004440)1.60332348
192Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.57109182
193Flat cornea (HP:0007720)1.56786001
194Abnormality of molar (HP:0011077)1.56029103
195Abnormality of molar morphology (HP:0011070)1.56029103
196Cervical subluxation (HP:0003308)1.55938888
197Micromelia (HP:0002983)1.55472498

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK47.51617562
2BCKDK7.05140409
3SIK14.25031305
4FGFR44.17744244
5ERN13.81393437
6CDC42BPA3.46285051
7ERBB43.20957758
8PDGFRA2.97547804
9TAOK32.92830393
10INSRR2.80797777
11WNK42.69582302
12WNK32.67580238
13TYRO32.45603408
14MST1R2.43996943
15PIK3CG2.22530362
16OXSR12.12488273
17MAP3K62.00302463
18PRPF4B1.98561564
19MAP4K21.94930403
20MAP2K41.86645231
21MAPK111.83136052
22PLK21.78842149
23CLK11.58427022
24BRD41.57663331
25CAMK1G1.51494118
26PKN21.51474558
27DAPK21.48102518
28TYK21.45241456
29FLT31.36782683
30MAP3K71.32195607
31GRK61.31537050
32TRIB31.28971085
33PDGFRB1.28686474
34PRKAA21.28489847
35CASK1.27780821
36MAPK151.27501086
37LATS11.27129851
38PTK61.24693825
39NEK61.22100131
40DDR21.20261422
41NEK91.18701346
42SGK2231.18554491
43SGK4941.18554491
44MAPKAPK51.18404101
45PDK21.17602700
46STK38L1.16071896
47NLK1.15752662
48FGFR21.12017490
49JAK21.11509067
50EPHB21.10259126
51SGK21.09224934
52STK381.08618387
53NEK21.06821261
54PRKCZ1.05864113
55MET1.05037586
56NTRK11.04333249
57MAPK41.03570640
58ABL21.03334216
59LATS21.02047421
60SGK31.01993869
61PINK10.96823196
62KDR0.94344993
63TIE10.93820360
64RPS6KA50.90618847
65RIPK10.88720971
66NTRK20.88489695
67PNCK0.86021852
68MAPK120.85982540
69EPHB10.85912834
70PRKACG0.84826961
71JAK10.84687975
72NME10.84485594
73GRK10.83894772
74STK390.83890403
75PTK20.83671990
76ERBB20.82450012
77GSK3A0.81498000
78FRK0.81148842
79PRKAA10.80744958
80EPHA40.78189804
81CAMK2G0.77070319
82MAP3K100.75956548
83DYRK1B0.74818528
84FER0.73904634
85PRKCG0.70622887
86PRKD30.66674283
87MAPK70.64083877
88MAP2K20.61754391
89PAK20.61657132
90TAOK20.61027981
91DAPK30.59636484
92MAP3K120.58755707
93CSNK1G10.56273457
94MAPK130.56006979
95MINK10.55378511
96PRKG20.54727639
97EEF2K0.54482012
98ROCK10.54350936
99MAP3K140.54244225
100PKN10.52879151
101EPHA30.52395554
102TBK10.51470426
103MAP2K30.51336455
104PDK30.50926267
105PDK40.50926267
106CSK0.49865950
107MAP2K60.49003852
108PDPK10.47783944
109MAP2K10.47449167
110CAMK40.47232585
111JAK30.46084160
112MARK20.46008424
113TGFBR20.45673451
114MAPK10.44049777
115CAMK10.44001570
116IGF1R0.42406054
117DYRK20.40326277
118PRKCQ0.39525430
119MAP3K30.39462374
120PRKCA0.39056038
121ADRBK20.37388478
122SCYL20.35754550
123RPS6KA20.35173723
124TESK10.34969739
125MAP3K50.34004994
126FGFR30.33661530
127CDK60.33532328
128CDK120.33291969
129PIK3CA0.33222065
130CSF1R0.33177337
131PRKACA0.31545128
132CSNK1A1L0.30704812
133CAMK1D0.29616659
134PRKACB0.29167106
135CSNK1G30.28507001
136STK160.28479223
137RPS6KA30.27906368
138PDK10.27831596
139PRKCB0.27726165
140CAMK2A0.26471989
141MAPK30.26438426
142IKBKE0.26206077
143MTOR0.26190209
144PTK2B0.25654023
145RET0.25514437
146MYLK0.24615702
147PRKG10.23163029
148ICK0.22546205
149PRKCH0.22475062
150SIK20.22435862
151AKT30.22435305
152EGFR0.22349970
153ADRBK10.22164515

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.37366710
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.33042515
3Nitrogen metabolism_Homo sapiens_hsa009103.31521543
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.23911184
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.19972037
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.98792442
7ECM-receptor interaction_Homo sapiens_hsa045122.88338696
8Arginine biosynthesis_Homo sapiens_hsa002202.80010934
9Tryptophan metabolism_Homo sapiens_hsa003802.70402554
10Complement and coagulation cascades_Homo sapiens_hsa046102.65172814
11Butanoate metabolism_Homo sapiens_hsa006502.64050656
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.62264979
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.62084382
14Fatty acid degradation_Homo sapiens_hsa000712.61524672
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.59496577
16Amoebiasis_Homo sapiens_hsa051462.39075349
17Peroxisome_Homo sapiens_hsa041462.24528876
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.22254821
19Pentose and glucuronate interconversions_Homo sapiens_hsa000402.20317673
20Propanoate metabolism_Homo sapiens_hsa006402.11855626
21Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.02847671
22Fatty acid metabolism_Homo sapiens_hsa012121.96742086
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.90250644
24PPAR signaling pathway_Homo sapiens_hsa033201.86745957
25beta-Alanine metabolism_Homo sapiens_hsa004101.75029621
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.74819881
27Histidine metabolism_Homo sapiens_hsa003401.74187388
28Chemical carcinogenesis_Homo sapiens_hsa052041.72218896
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.67126172
30Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.65673230
31Selenocompound metabolism_Homo sapiens_hsa004501.63693345
32Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.62390841
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.62305164
34Drug metabolism - other enzymes_Homo sapiens_hsa009831.56830515
35Bile secretion_Homo sapiens_hsa049761.56401895
36Staphylococcus aureus infection_Homo sapiens_hsa051501.55884696
37Focal adhesion_Homo sapiens_hsa045101.54014625
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.53734432
39Retinol metabolism_Homo sapiens_hsa008301.53187171
40Pyruvate metabolism_Homo sapiens_hsa006201.52502154
41Phenylalanine metabolism_Homo sapiens_hsa003601.46300908
42Sulfur metabolism_Homo sapiens_hsa009201.43686911
43Fatty acid elongation_Homo sapiens_hsa000621.40199877
44Hedgehog signaling pathway_Homo sapiens_hsa043401.37994393
45Tyrosine metabolism_Homo sapiens_hsa003501.35531130
46Cyanoamino acid metabolism_Homo sapiens_hsa004601.35071676
47Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.34165699
48Vascular smooth muscle contraction_Homo sapiens_hsa042701.33286585
49Other glycan degradation_Homo sapiens_hsa005111.30904973
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.29649265
51Caffeine metabolism_Homo sapiens_hsa002321.29316793
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.28085278
53Cysteine and methionine metabolism_Homo sapiens_hsa002701.24183585
54Nicotine addiction_Homo sapiens_hsa050331.23474545
55Starch and sucrose metabolism_Homo sapiens_hsa005001.22310010
56Carbon metabolism_Homo sapiens_hsa012001.19843733
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.18544119
58Choline metabolism in cancer_Homo sapiens_hsa052311.18005340
59Maturity onset diabetes of the young_Homo sapiens_hsa049501.17892660
60Vitamin digestion and absorption_Homo sapiens_hsa049771.16602424
61Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.15782913
62ABC transporters_Homo sapiens_hsa020101.12563796
63Folate biosynthesis_Homo sapiens_hsa007901.12055583
64Fat digestion and absorption_Homo sapiens_hsa049751.10732238
65Biosynthesis of amino acids_Homo sapiens_hsa012301.09972163
66Gap junction_Homo sapiens_hsa045401.09676107
67Aldosterone synthesis and secretion_Homo sapiens_hsa049251.07250035
68Sphingolipid metabolism_Homo sapiens_hsa006001.05849301
69Steroid biosynthesis_Homo sapiens_hsa001001.03584114
70Arginine and proline metabolism_Homo sapiens_hsa003301.02732736
71Small cell lung cancer_Homo sapiens_hsa052221.01759655
72Lysine degradation_Homo sapiens_hsa003100.98742844
73TGF-beta signaling pathway_Homo sapiens_hsa043500.98646991
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.97629927
75Vitamin B6 metabolism_Homo sapiens_hsa007500.94267761
76Inositol phosphate metabolism_Homo sapiens_hsa005620.91632930
77N-Glycan biosynthesis_Homo sapiens_hsa005100.90833282
78Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.87514198
79Sulfur relay system_Homo sapiens_hsa041220.87120986
80Cocaine addiction_Homo sapiens_hsa050300.87108869
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.87025461
82Platelet activation_Homo sapiens_hsa046110.86207657
83Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.84654709
84Basal cell carcinoma_Homo sapiens_hsa052170.82766031
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82482392
86VEGF signaling pathway_Homo sapiens_hsa043700.72920775
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70163287
88Hippo signaling pathway_Homo sapiens_hsa043900.70023099
89Toxoplasmosis_Homo sapiens_hsa051450.69930270
90Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.69355811
91Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68093332
92Glycerolipid metabolism_Homo sapiens_hsa005610.67984598
93One carbon pool by folate_Homo sapiens_hsa006700.67518056
94Proteoglycans in cancer_Homo sapiens_hsa052050.66871570
95Olfactory transduction_Homo sapiens_hsa047400.64491577
96Glutathione metabolism_Homo sapiens_hsa004800.64355086
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63771628
98Calcium signaling pathway_Homo sapiens_hsa040200.63181980
99PI3K-Akt signaling pathway_Homo sapiens_hsa041510.61086476
100Renin secretion_Homo sapiens_hsa049240.58363361
101Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57219481
102Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56674192
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53632259
104Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.52236222
105Metabolic pathways_Homo sapiens_hsa011000.50146649
106Pentose phosphate pathway_Homo sapiens_hsa000300.49645128
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47135014
108Prolactin signaling pathway_Homo sapiens_hsa049170.46813549
109Phospholipase D signaling pathway_Homo sapiens_hsa040720.45579784
110Adherens junction_Homo sapiens_hsa045200.45013642
111Pancreatic secretion_Homo sapiens_hsa049720.43690803
112MAPK signaling pathway_Homo sapiens_hsa040100.43548054
113Fatty acid biosynthesis_Homo sapiens_hsa000610.41943731
114Jak-STAT signaling pathway_Homo sapiens_hsa046300.41887192
115Ras signaling pathway_Homo sapiens_hsa040140.40758110
116Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.40455938
117Dilated cardiomyopathy_Homo sapiens_hsa054140.39504944
118Serotonergic synapse_Homo sapiens_hsa047260.38221903
119Axon guidance_Homo sapiens_hsa043600.37500515
120Glutamatergic synapse_Homo sapiens_hsa047240.36449427
121alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.35658353
122Wnt signaling pathway_Homo sapiens_hsa043100.34951348
123GnRH signaling pathway_Homo sapiens_hsa049120.33764769
124Endocytosis_Homo sapiens_hsa041440.33275052
125Alcoholism_Homo sapiens_hsa050340.33124859
126Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32934026
127Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.32831569
128Prion diseases_Homo sapiens_hsa050200.32310775
129Fructose and mannose metabolism_Homo sapiens_hsa000510.30775811
130Galactose metabolism_Homo sapiens_hsa000520.26492005
131Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.24110067
132Linoleic acid metabolism_Homo sapiens_hsa005910.23395036
133Insulin resistance_Homo sapiens_hsa049310.21023710
134Adipocytokine signaling pathway_Homo sapiens_hsa049200.20233440
135Glycerophospholipid metabolism_Homo sapiens_hsa005640.13162718
136Glucagon signaling pathway_Homo sapiens_hsa049220.12340448
137Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.06438634
138AMPK signaling pathway_Homo sapiens_hsa041520.01620177
139Bladder cancer_Homo sapiens_hsa05219-0.2177423
140Phototransduction_Homo sapiens_hsa04744-0.2146351
141African trypanosomiasis_Homo sapiens_hsa05143-0.2137234
142Systemic lupus erythematosus_Homo sapiens_hsa05322-0.2131472
143Hepatitis C_Homo sapiens_hsa05160-0.1967217
144Mineral absorption_Homo sapiens_hsa04978-0.1902342
145Regulation of autophagy_Homo sapiens_hsa04140-0.1671578
146Collecting duct acid secretion_Homo sapiens_hsa04966-0.1599262
147Ether lipid metabolism_Homo sapiens_hsa00565-0.1497427
148Oxidative phosphorylation_Homo sapiens_hsa00190-0.1462477
149Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1360445
150Insulin signaling pathway_Homo sapiens_hsa04910-0.1314529
151Protein digestion and absorption_Homo sapiens_hsa04974-0.1293423
152Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1118153
153Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1087154
154Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0995470
155Renin-angiotensin system_Homo sapiens_hsa04614-0.0769376
156Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0662556
157Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0545598
158Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0372963

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