PROK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein expressed in the suprachiasmatic nucleus (SCN) circadian clock that may function as the output component of the circadian clock. The secreted form of the encoded protein may also serve as a chemoattractant for neuronal precursor cells in the olfactory bulb. Proteins from other vertebrates which are similar to this gene product were isolated based on homology to snake venom and secretions from frog skin, and have been shown to have diverse functions. Mutations in this gene are associated with Kallmann syndrome 4. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1motile cilium assembly (GO:0044458)9.80297795
2acrosome assembly (GO:0001675)9.79762400
3plasma membrane fusion (GO:0045026)9.67921563
4cell wall macromolecule catabolic process (GO:0016998)9.18868852
5cell wall macromolecule metabolic process (GO:0044036)9.18868852
6epithelial cilium movement (GO:0003351)9.16175821
7male meiosis (GO:0007140)8.97144885
8cell-cell recognition (GO:0009988)8.93756847
9binding of sperm to zona pellucida (GO:0007339)8.90832810
10reproduction (GO:0000003)8.45087153
11spermatid development (GO:0007286)8.18764152
12synaptonemal complex organization (GO:0070193)8.12190035
13cilium movement (GO:0003341)8.08576242
14epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.00936892
15synaptonemal complex assembly (GO:0007130)7.82465514
16DNA methylation involved in gamete generation (GO:0043046)7.35026723
17regulation of cilium movement (GO:0003352)6.82006236
18single fertilization (GO:0007338)6.69994050
19modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.63524235
20positive regulation by organism of defense response of other organism involved in symbiotic interact6.63524235
21modulation by symbiont of host immune response (GO:0052553)6.63524235
22positive regulation by symbiont of host defense response (GO:0052509)6.63524235
23modulation by symbiont of host defense response (GO:0052031)6.63524235
24modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.63524235
25negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.08615839
26negative regulation of cell killing (GO:0031342)6.08615839
27sperm capacitation (GO:0048240)6.04928754
28antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.92965416
29detection of molecule of bacterial origin (GO:0032490)5.66605338
30fertilization (GO:0009566)5.66232328
31chromosome organization involved in meiosis (GO:0070192)5.62471914
32positive regulation of gamma-delta T cell activation (GO:0046645)5.62377191
33neutrophil activation involved in immune response (GO:0002283)5.61398066
34meiotic nuclear division (GO:0007126)5.44729245
35detection of other organism (GO:0098543)5.42366150
36microtubule depolymerization (GO:0007019)5.40125360
37male meiosis I (GO:0007141)5.39422920
38macrophage activation involved in immune response (GO:0002281)5.38374338
39leukocyte migration involved in inflammatory response (GO:0002523)5.34169411
40* spermatogenesis (GO:0007283)5.33451723
41* male gamete generation (GO:0048232)5.31125385
42positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)5.30207482
43negative regulation of inclusion body assembly (GO:0090084)5.24980852
44ventricular system development (GO:0021591)5.21770606
45meiotic cell cycle (GO:0051321)5.16408107
46response to peptidoglycan (GO:0032494)5.16179348
47antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.03851774
48detection of external biotic stimulus (GO:0098581)5.02629161
49leukocyte aggregation (GO:0070486)4.98092901
50detection of bacterium (GO:0016045)4.92517666
51calcium ion-dependent exocytosis (GO:0017156)4.92277836
52* gamete generation (GO:0007276)4.87244514
53antigen processing and presentation of endogenous antigen (GO:0019883)4.85441016
54germ cell development (GO:0007281)4.85187625
55cellular process involved in reproduction in multicellular organism (GO:0022412)4.79637701
56regulation of inclusion body assembly (GO:0090083)4.76546325
57regulation of B cell receptor signaling pathway (GO:0050855)4.75681795
58regulation of interferon-beta biosynthetic process (GO:0045357)4.74789081
59neutrophil activation (GO:0042119)4.64056481
60microglial cell activation (GO:0001774)4.60065806
61response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.57733324
62response to host immune response (GO:0052572)4.57733324
63negative regulation of interleukin-12 production (GO:0032695)4.54067228
64organic cation transport (GO:0015695)4.50266546
65cell recognition (GO:0008037)4.47373804
66antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.46530666
67negative regulation of lymphocyte mediated immunity (GO:0002707)4.46350552
68detection of biotic stimulus (GO:0009595)4.41411890
69regulation of meiosis I (GO:0060631)4.40616975
70respiratory burst (GO:0045730)4.35491236
71response to interleukin-15 (GO:0070672)4.32778236
72neutrophil mediated immunity (GO:0002446)4.27745068
73negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.22029064
74macrophage activation (GO:0042116)4.21946670
75protein localization to cilium (GO:0061512)4.21864658
76microtubule severing (GO:0051013)4.19606090
77response to host (GO:0075136)4.17878828
78response to host defenses (GO:0052200)4.17878828
79response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.17878828
80production of molecular mediator involved in inflammatory response (GO:0002532)4.15994281
81meiosis I (GO:0007127)4.15801384
82granulocyte activation (GO:0036230)4.15109220
83gene silencing by RNA (GO:0031047)4.11824792
84regulation of gamma-delta T cell activation (GO:0046643)4.09608371
85positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.05611580
86positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.00066183
87seminiferous tubule development (GO:0072520)3.95431291
88immunoglobulin mediated immune response (GO:0016064)3.92247434
89cellular response to interleukin-15 (GO:0071350)3.88213616
90myeloid cell activation involved in immune response (GO:0002275)3.87336994
91negative regulation of leukocyte mediated immunity (GO:0002704)3.86784840
92* multicellular organismal reproductive process (GO:0048609)3.83771251
93regulation of microtubule-based movement (GO:0060632)3.72378765
94regulation of mast cell degranulation (GO:0043304)3.70803812
95negative regulation of T-helper cell differentiation (GO:0045623)3.69312357
96negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.69312357
97myeloid leukocyte mediated immunity (GO:0002444)3.68260937
98left/right pattern formation (GO:0060972)3.67368794
99regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.63518642
100negative regulation of T cell mediated immunity (GO:0002710)3.56019149
101presynaptic membrane organization (GO:0097090)3.53862880
102regulation of gamma-delta T cell differentiation (GO:0045586)3.53222290
103germinal center formation (GO:0002467)3.52589764
104regulation of T-helper 2 cell differentiation (GO:0045628)3.50471872
105regulation of myeloid leukocyte mediated immunity (GO:0002886)3.49559255
106negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.49404547
107cellular response to type I interferon (GO:0071357)3.44510390
108type I interferon signaling pathway (GO:0060337)3.44510390
109regulation of mast cell activation involved in immune response (GO:0033006)3.42168692
110response to type I interferon (GO:0034340)3.41140340
111positive regulation of mast cell activation (GO:0033005)3.38503795
112leukocyte degranulation (GO:0043299)3.30539335
113axoneme assembly (GO:0035082)3.29023323
114regulation of mast cell activation (GO:0033003)3.28248627
115B cell receptor signaling pathway (GO:0050853)3.26829789
116neutrophil chemotaxis (GO:0030593)3.26225117
117regulation of leukocyte degranulation (GO:0043300)3.26128242
118defense response to protozoan (GO:0042832)3.25945420
119protein polyglutamylation (GO:0018095)3.24894405
120antigen processing and presentation via MHC class Ib (GO:0002475)3.24439304
121regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.24323458
122response to muramyl dipeptide (GO:0032495)3.24296639
123spermatid nucleus differentiation (GO:0007289)3.21409266
124regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.20853360
125intraciliary transport (GO:0042073)3.19756743
126multicellular organismal development (GO:0007275)3.19011309
127neutrophil migration (GO:1990266)3.17978432
128genitalia morphogenesis (GO:0035112)3.17660561
129dendritic cell migration (GO:0036336)3.17271487
130B cell mediated immunity (GO:0019724)3.16188552
131positive regulation of interferon-alpha production (GO:0032727)3.15512575
132negative regulation of phagocytosis (GO:0050765)3.15469157
133negative regulation of B cell mediated immunity (GO:0002713)3.14530530
134negative regulation of immunoglobulin mediated immune response (GO:0002890)3.14530530
135protein K11-linked deubiquitination (GO:0035871)3.14039067
136positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.13709524
137negative regulation of type 2 immune response (GO:0002829)3.13528238
138lipopolysaccharide-mediated signaling pathway (GO:0031663)3.13173639
139negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.09735344
140meiotic cell cycle process (GO:1903046)3.08593217
141dendritic cell chemotaxis (GO:0002407)3.08137234
142cilium organization (GO:0044782)3.06721955
143monoubiquitinated protein deubiquitination (GO:0035520)3.05579296
144regulation of B cell differentiation (GO:0045577)3.04314410
145negative regulation of interleukin-6 production (GO:0032715)3.03739375
146myeloid leukocyte activation (GO:0002274)3.02042674
147microtubule-based movement (GO:0007018)3.00106642
148cilium assembly (GO:0042384)3.00016496
149cilium morphogenesis (GO:0060271)2.99209190
150synapsis (GO:0007129)2.96589573
151regulation of regulated secretory pathway (GO:1903305)2.95589356
152positive regulation of cellular amide metabolic process (GO:0034250)2.94832122
153alditol metabolic process (GO:0019400)2.94479654
154negative regulation of erythrocyte differentiation (GO:0045647)2.94091067
155positive regulation of toll-like receptor signaling pathway (GO:0034123)2.93939938
156regulation of tolerance induction (GO:0002643)2.93868794
157positive regulation of B cell differentiation (GO:0045579)2.93807023
158positive regulation of mast cell degranulation (GO:0043306)2.93494108
159positive regulation of mast cell activation involved in immune response (GO:0033008)2.93494108
160negative regulation of alpha-beta T cell activation (GO:0046636)2.93212941
161negative regulation of organelle assembly (GO:1902116)2.92377310
162microtubule polymerization or depolymerization (GO:0031109)2.89485706
163glycerol metabolic process (GO:0006071)2.86399103
164carnitine transmembrane transport (GO:1902603)2.78448774
165cellular component assembly involved in morphogenesis (GO:0010927)2.77419457
166presynaptic membrane assembly (GO:0097105)2.77243874
167amino-acid betaine transport (GO:0015838)2.74698582
168carnitine transport (GO:0015879)2.74698582
169negative regulation of skeletal muscle tissue development (GO:0048642)2.66666359
170polyol catabolic process (GO:0046174)2.66618916
171regulation of spindle checkpoint (GO:0090231)2.66496162
172positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.57890367
173regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.57890367
174ether metabolic process (GO:0018904)2.56621869
175lactate metabolic process (GO:0006089)2.52327516
176negative regulation of mast cell activation (GO:0033004)2.52307880
177glycerol ether metabolic process (GO:0006662)2.48059805
178glycolytic process (GO:0006096)2.47044957
179phosphatidylglycerol biosynthetic process (GO:0006655)2.46078538
180gene silencing (GO:0016458)2.44927894
181response to acidic pH (GO:0010447)2.44829735
182regulation of centriole replication (GO:0046599)2.44548422
183peptidyl-glutamic acid modification (GO:0018200)2.44363131
184sex differentiation (GO:0007548)2.43717193
185DNA alkylation (GO:0006305)2.39008597
186DNA methylation (GO:0006306)2.39008597
187cellular extravasation (GO:0045123)2.34208706
188sexual reproduction (GO:0019953)2.32919758
189regulation of acrosome reaction (GO:0060046)2.29548767
190nucleus organization (GO:0006997)2.24053432
191rRNA catabolic process (GO:0016075)2.22944874
192cilium or flagellum-dependent cell motility (GO:0001539)14.3332860
193piRNA metabolic process (GO:0034587)12.3872173
194fusion of sperm to egg plasma membrane (GO:0007342)12.3237865
195sperm motility (GO:0030317)10.7263864
196axonemal dynein complex assembly (GO:0070286)10.7197741
197acrosome reaction (GO:0007340)10.2557182
198multicellular organism reproduction (GO:0032504)10.1999212
199sperm-egg recognition (GO:0035036)10.0085137

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.27252872
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.24229416
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.07839593
4EZH2_22144423_ChIP-Seq_EOC_Human5.05116828
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.90204017
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.50244775
7IRF8_21731497_ChIP-ChIP_J774_Mouse4.39949826
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.92199267
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.84141239
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.75616264
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.37922951
12IRF8_27001747_Chip-Seq_BMDM_Mouse3.32090202
13MYB_21317192_ChIP-Seq_ERMYB_Mouse3.10018722
14SPI1_23547873_ChIP-Seq_NB4_Human2.92754553
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.90782086
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.82643291
17VDR_24763502_ChIP-Seq_THP-1_Human2.79470673
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.78520671
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.76358940
20RUNX_20019798_ChIP-Seq_JUKART_Human2.74261540
21SPI1_23127762_ChIP-Seq_K562_Human2.67731824
22VDR_21846776_ChIP-Seq_THP-1_Human2.64443535
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.48153680
24SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.42207961
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.39409504
26MYB_26560356_Chip-Seq_TH2_Human2.34967444
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.33663102
28STAT6_21828071_ChIP-Seq_BEAS2B_Human2.33390484
29MAF_26560356_Chip-Seq_TH1_Human2.30430570
30RUNX1_22412390_ChIP-Seq_EML_Mouse2.29721082
31SCL_19346495_ChIP-Seq_HPC-7_Human2.27458021
32EGR1_19374776_ChIP-ChIP_THP-1_Human2.23043825
33BRD4_27068464_Chip-Seq_AML-cells_Mouse2.22464102
34STAT4_19710469_ChIP-ChIP_TH1__Mouse2.20012420
35FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.18301713
36PCGF2_27294783_Chip-Seq_ESCs_Mouse2.13184059
37E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.09268836
38NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.08803347
39ELK4_26923725_Chip-Seq_MESODERM_Mouse2.08586841
40FLI1_27457419_Chip-Seq_LIVER_Mouse2.07506867
41* UTX_26944678_Chip-Seq_JUKART_Human2.06689700
42STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.06499281
43MYB_26560356_Chip-Seq_TH1_Human2.01832230
44VDR_22108803_ChIP-Seq_LS180_Human2.00573751
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.98854262
46EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.91876556
47VDR_24787735_ChIP-Seq_THP-1_Human1.91182828
48TCF7_22412390_ChIP-Seq_EML_Mouse1.89844588
49VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.89279508
50MYC_22102868_ChIP-Seq_BL_Human1.79918301
51MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.79868130
52KDM2B_26808549_Chip-Seq_SUP-B15_Human1.76600484
53NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.74299490
54RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.73420354
55ZFP57_27257070_Chip-Seq_ESCs_Mouse1.71982246
56PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.70963496
57GATA3_27048872_Chip-Seq_THYMUS_Human1.70065678
58NFE2_27457419_Chip-Seq_LIVER_Mouse1.67210939
59LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.67109653
60CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.63536603
61MAF_26560356_Chip-Seq_TH2_Human1.62618424
62* REST_21632747_ChIP-Seq_MESCs_Mouse1.60209278
63GATA1_26923725_Chip-Seq_HPCs_Mouse1.59458846
64KDM2B_26808549_Chip-Seq_DND41_Human1.56483181
65SUZ12_27294783_Chip-Seq_NPCs_Mouse1.56421869
66PCGF2_27294783_Chip-Seq_NPCs_Mouse1.56181361
67GATA1_19941827_ChIP-Seq_MEL_Mouse1.54302856
68TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.53304108
69GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53183252
70TAL1_26923725_Chip-Seq_HPCs_Mouse1.50970999
71TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.50773701
72KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.45970575
73LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.44496785
74* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.43472749
75GATA2_22383799_ChIP-Seq_G1ME_Mouse1.43369166
76STAT1_17558387_ChIP-Seq_HELA_Human1.43335700
77CBX2_27304074_Chip-Seq_ESCs_Mouse1.43097688
78PU_27001747_Chip-Seq_BMDM_Mouse1.41032871
79FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.39724526
80GATA3_26560356_Chip-Seq_TH2_Human1.39155725
81PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.38802062
82TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37853342
83POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.37853342
84SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.37469787
85CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.37271680
86EZH2_27294783_Chip-Seq_NPCs_Mouse1.36850765
87* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.36209445
88KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.36117676
89TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.34606329
90KAP1_22055183_ChIP-Seq_ESCs_Mouse1.34592112
91KDM2B_26808549_Chip-Seq_REH_Human1.32859069
92CRX_20693478_ChIP-Seq_RETINA_Mouse1.32498858
93CTBP2_25329375_ChIP-Seq_LNCAP_Human1.31725072
94THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.30733188
95GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30672750
96GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.28982586
97FLI1_21867929_ChIP-Seq_TH2_Mouse1.28850229
98MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.28685410
99CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.27620867
100ZNF274_21170338_ChIP-Seq_K562_Hela1.26108275
101TAF15_26573619_Chip-Seq_HEK293_Human1.25653522
102IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25322553
103CBP_20019798_ChIP-Seq_JUKART_Human1.25322553
104GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.23864894
105GATA1_22383799_ChIP-Seq_G1ME_Mouse1.23484764
106EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.23356565
107CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.22779253
108CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21735421
109SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21408570
110CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.21166706
111NANOG_18555785_Chip-Seq_ESCs_Mouse1.19985080
112SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19902150
113OCT4_21477851_ChIP-Seq_ESCs_Mouse1.19270360
114* RNF2_27304074_Chip-Seq_NSC_Mouse1.18941964
115GATA2_21666600_ChIP-Seq_HMVEC_Human1.18287536
116EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.17389971
117SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.17077684
118OCT4_18555785_Chip-Seq_ESCs_Mouse1.16661025
119P53_22387025_ChIP-Seq_ESCs_Mouse1.16110623
120P300_18555785_Chip-Seq_ESCs_Mouse1.15790844
121STAT3_18555785_Chip-Seq_ESCs_Mouse1.15130891
122PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14757491
123GATA1_22025678_ChIP-Seq_K562_Human1.14681814
124PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14490057
125GATA3_21867929_ChIP-Seq_CD8_Mouse1.13703511
126SUZ12_18555785_Chip-Seq_ESCs_Mouse1.13028523
127RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.12528374
128ELK3_25401928_ChIP-Seq_HUVEC_Human1.11589462
129ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.10069274
130GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09979061
131FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09947124
132KLF4_18555785_Chip-Seq_ESCs_Mouse1.09929034
133* SMAD4_21799915_ChIP-Seq_A2780_Human1.09165203
134CTBP1_25329375_ChIP-Seq_LNCAP_Human1.08203671
135VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.08157754
136KDM2B_26808549_Chip-Seq_JURKAT_Human1.07898582
137RUNX1_27457419_Chip-Seq_LIVER_Mouse1.07611187
138RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.07499555
139SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07218805
140RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.06688887
141SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.06270279
142ESRRB_18555785_Chip-Seq_ESCs_Mouse1.06245541
143LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.04921262
144PU1_27457419_Chip-Seq_LIVER_Mouse1.04905633
145PU.1_20513432_ChIP-Seq_Bcells_Mouse1.04746334
146ELF1_17652178_ChIP-ChIP_JURKAT_Human1.04187455
147GATA1_19941826_ChIP-Seq_K562_Human1.03648916
148WDR5_24793694_ChIP-Seq_LNCAP_Human1.02681988
149SOX2_22085726_ChIP-Seq_NPCs_Mouse1.02364733
150MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02176648
151E2F1_18555785_Chip-Seq_ESCs_Mouse1.02068434
152CMYC_18555785_Chip-Seq_ESCs_Mouse1.01604865
153* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.00717496
154RAD21_21589869_ChIP-Seq_MESCs_Mouse1.00062681
155* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00007415
156IKZF1_21737484_ChIP-ChIP_HCT116_Human0.99985552
157PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.99144046
158SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.99131252
159ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.98941805
160SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98685901
161GF1_26923725_Chip-Seq_HPCs_Mouse0.98535946
162ER_23166858_ChIP-Seq_MCF-7_Human0.97836118
163TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97071728
164GATA3_21867929_ChIP-Seq_TH1_Mouse0.96487863
165TCF4_23295773_ChIP-Seq_U87_Human0.96304561
166RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.96282236
167NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.95973647
168STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.95462774
169BCAT_22108803_ChIP-Seq_LS180_Human0.94980855
170GF1B_26923725_Chip-Seq_HPCs_Mouse0.94410781
171GATA2_19941826_ChIP-Seq_K562_Human0.94397979
172CTCF_18555785_Chip-Seq_ESCs_Mouse0.93361665
173UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93053519
174SMAD1_18555785_Chip-Seq_ESCs_Mouse0.92818371
175SOX2_18555785_Chip-Seq_ESCs_Mouse0.92189257
176BCL6_27268052_Chip-Seq_Bcells_Human0.89871946
177ZFX_18555785_Chip-Seq_ESCs_Mouse0.89392458
178* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89062069
179LXR_22292898_ChIP-Seq_THP-1_Human0.88879408
180MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.88230609
181GBX2_23144817_ChIP-Seq_PC3_Human0.87177422
182ESET_19884257_ChIP-Seq_ESCs_Mouse0.86602036
183RUNX1_26923725_Chip-Seq_HPCs_Mouse0.86109920
184SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.85914021
185MYC_27129775_Chip-Seq_CORNEA_Mouse0.85718358
186Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.85531895
187NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.85395438
188TBL1_22424771_ChIP-Seq_293T_Human0.85077921
189NCOR1_26117541_ChIP-Seq_K562_Human0.84301208
190BCOR_27268052_Chip-Seq_Bcells_Human0.82836733
191SPI1_20517297_ChIP-Seq_HL60_Human0.81115902
192GATA1_19941827_ChIP-Seq_MEL86_Mouse0.80440960
193TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.77567473
194CTCF_27219007_Chip-Seq_ERYTHROID_Human0.72588900

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to6.29633709
2MP0003698_abnormal_male_reproductive5.24931723
3MP0008877_abnormal_DNA_methylation4.96884859
4MP0001929_abnormal_gametogenesis4.85368822
5MP0002653_abnormal_ependyma_morphology3.75354995
6MP0001835_abnormal_antigen_presentation3.60809762
7MP0002210_abnormal_sex_determination3.42223655
8MP0005025_abnormal_response_to2.90855930
9MP0001145_abnormal_male_reproductive2.90606807
10MP0001800_abnormal_humoral_immune2.79902961
11MP0005000_abnormal_immune_tolerance2.75882341
12MP0002161_abnormal_fertility/fecundity2.69324122
13MP0000685_abnormal_immune_system2.68870271
14MP0005671_abnormal_response_to2.63094559
15MP0001790_abnormal_immune_system2.62216934
16MP0005387_immune_system_phenotype2.62216934
17MP0002723_abnormal_immune_serum2.55440858
18MP0000653_abnormal_sex_gland2.50385322
19MP0009046_muscle_twitch2.49505726
20MP0002420_abnormal_adaptive_immunity2.48436033
21MP0003191_abnormal_cellular_cholesterol2.47305128
22MP0001819_abnormal_immune_cell2.45750597
23MP0002452_abnormal_antigen_presenting2.41418952
24MP0006082_CNS_inflammation2.39428832
25MP0002132_abnormal_respiratory_system2.24725097
26MP0002148_abnormal_hypersensitivity_rea2.20421742
27MP0003300_gastrointestinal_ulcer2.15812516
28MP0003303_peritoneal_inflammation2.15450035
29MP0005464_abnormal_platelet_physiology2.13559976
30MP0005410_abnormal_fertilization13.1028583
31MP0003828_pulmonary_edema1.97035426
32MP0009278_abnormal_bone_marrow1.96918986
33MP0005623_abnormal_meninges_morphology1.89234751
34MP0002398_abnormal_bone_marrow1.86617453
35MP0008995_early_reproductive_senescence1.86345430
36MP0000716_abnormal_immune_system1.83162485
37MP0000015_abnormal_ear_pigmentation1.81679876
38MP0000465_gastrointestinal_hemorrhage1.80402449
39MP0003763_abnormal_thymus_physiology1.79935279
40MP0002282_abnormal_trachea_morphology1.77734392
41MP0005409_darkened_coat_color1.74940429
42MP0001845_abnormal_inflammatory_respons1.74875031
43MP0002396_abnormal_hematopoietic_system1.71978779
44MP0010155_abnormal_intestine_physiology1.71756570
45MP0004947_skin_inflammation1.60102466
46MP0005451_abnormal_body_composition1.59932521
47MP0003172_abnormal_lysosome_physiology1.59074941
48MP0003866_abnormal_defecation1.55351900
49MP0002722_abnormal_immune_system1.54945629
50MP0002837_dystrophic_cardiac_calcinosis1.53404015
51MP0004883_abnormal_blood_vessel1.53389173
52MP0000689_abnormal_spleen_morphology1.50876767
53MP0003183_abnormal_peptide_metabolism1.49198950
54MP0002160_abnormal_reproductive_system1.48159322
55MP0002429_abnormal_blood_cell1.44626211
56MP0008469_abnormal_protein_level1.43741079
57MP0004381_abnormal_hair_follicle1.40686236
58MP0000858_altered_metastatic_potential1.38104018
59MP0000703_abnormal_thymus_morphology1.35891732
60MP0005164_abnormal_response_to1.33581589
61MP0003646_muscle_fatigue1.32610924
62MP0005647_abnormal_sex_gland1.32297025
63MP0005646_abnormal_pituitary_gland1.30425001
64MP0001851_eye_inflammation1.29916219
65MP0009333_abnormal_splenocyte_physiolog1.28509766
66MP0004130_abnormal_muscle_cell1.24237646
67MP0005174_abnormal_tail_pigmentation1.21638169
68MP0001984_abnormal_olfaction1.20755991
69MP0008004_abnormal_stomach_pH1.20409269
70MP0002102_abnormal_ear_morphology1.19917301
71MP0004510_myositis1.17321203
72MP0004134_abnormal_chest_morphology1.17067219
73MP0002998_abnormal_bone_remodeling1.16158790
74MP0005310_abnormal_salivary_gland1.16156492
75MP0005167_abnormal_blood-brain_barrier1.15744594
76MP0005166_decreased_susceptibility_to1.05602894
77MP0003690_abnormal_glial_cell1.02666802
78MP0006292_abnormal_olfactory_placode1.02629644
79MP0005379_endocrine/exocrine_gland_phen0.99473691
80MP0008058_abnormal_DNA_repair0.99200154
81MP0002166_altered_tumor_susceptibility0.98403799
82MP0005670_abnormal_white_adipose0.95741560
83MP0005390_skeleton_phenotype0.94513104
84MP0003045_fibrosis0.93454395
85MP0003436_decreased_susceptibility_to0.91780921
86MP0000343_altered_response_to0.88362879
87MP0003656_abnormal_erythrocyte_physiolo0.88192472
88MP0009745_abnormal_behavioral_response0.87751549
89MP0002064_seizures0.86963768
90MP0009763_increased_sensitivity_to0.85214939
91MP0002735_abnormal_chemical_nociception0.83775823
92MP0001853_heart_inflammation0.83574117
93MP0003221_abnormal_cardiomyocyte_apopto0.83169086
94MP0001663_abnormal_digestive_system0.80477587
95MP0001188_hyperpigmentation0.80066379
96MP0002277_abnormal_respiratory_mucosa0.79912572
97MP0003787_abnormal_imprinting0.76154219
98MP0003635_abnormal_synaptic_transmissio0.76038343
99MP0003011_delayed_dark_adaptation0.76010946
100MP0009765_abnormal_xenobiotic_induced0.75949908
101MP0003786_premature_aging0.75816519
102MP0002736_abnormal_nociception_after0.73977247
103MP0004808_abnormal_hematopoietic_stem0.73484281
104MP0005075_abnormal_melanosome_morpholog0.71234816
105MP0005389_reproductive_system_phenotype0.70351774
106MP0000569_abnormal_digit_pigmentation0.70304461
107MP0001270_distended_abdomen0.69866337
108MP0002405_respiratory_system_inflammati0.66748555
109MP0002909_abnormal_adrenal_gland0.66526890
110MP0003806_abnormal_nucleotide_metabolis0.66483926
111MP0004484_altered_response_of0.66416865
112MP0002572_abnormal_emotion/affect_behav0.65880614
113MP0005058_abnormal_lysosome_morphology0.65498428
114MP0000358_abnormal_cell_content/0.65261464
115MP0008874_decreased_physiological_sensi0.64312174
116MP0003795_abnormal_bone_structure0.63096591
117MP0000490_abnormal_crypts_of0.62946271
118MP0002419_abnormal_innate_immunity0.62397906
119MP0003329_amyloid_beta_deposits0.61685281
120MP0000249_abnormal_blood_vessel0.61373847
121MP0001501_abnormal_sleep_pattern0.60300840
122MP0002006_tumorigenesis0.60157947
123MP0005319_abnormal_enzyme/_coenzyme0.59574125
124MP0002063_abnormal_learning/memory/cond0.57940396
125MP0003633_abnormal_nervous_system0.57675604
126MP0005503_abnormal_tendon_morphology0.57582278
127MP0001986_abnormal_taste_sensitivity0.57550259
128MP0005397_hematopoietic_system_phenotyp0.56625917
129MP0001545_abnormal_hematopoietic_system0.56625917
130MP0003115_abnormal_respiratory_system0.55667819
131MP0008260_abnormal_autophagy0.55186977
132MP0005388_respiratory_system_phenotype0.54163363
133MP0005377_hearing/vestibular/ear_phenot0.53616562
134MP0003878_abnormal_ear_physiology0.53616562
135MP0002254_reproductive_system_inflammat0.53510951
136MP0002163_abnormal_gland_morphology0.52977386
137MP0000639_abnormal_adrenal_gland0.52508131
138MP0006072_abnormal_retinal_apoptosis0.52046521
139MP0005376_homeostasis/metabolism_phenot0.51125860
140MP0002928_abnormal_bile_duct0.51015621
141MP0002971_abnormal_brown_adipose0.50543789
142MP0001968_abnormal_touch/_nociception0.49964277
143MP0009250_abnormal_appendicular_skeleto0.49706954
144MP0002733_abnormal_thermal_nociception0.48825454
145MP0003448_altered_tumor_morphology0.47964083
146MP0005253_abnormal_eye_physiology0.47807598
147MP0003279_aneurysm0.47756994
148MP0004811_abnormal_neuron_physiology0.45930782
149MP0002138_abnormal_hepatobiliary_system0.45869161
150MP0001440_abnormal_grooming_behavior0.45198050
151MP0001873_stomach_inflammation0.44982529
152MP0003631_nervous_system_phenotype0.44862361
153MP0009764_decreased_sensitivity_to0.44193935
154MP0005645_abnormal_hypothalamus_physiol0.43327589
155MP0005535_abnormal_body_temperature0.43088475
156MP0009785_altered_susceptibility_to0.42714941
157MP0004019_abnormal_vitamin_homeostasis0.42651542
158MP0001765_abnormal_ion_homeostasis0.42430700
159MP0002332_abnormal_exercise_endurance0.42288078
160MP0005595_abnormal_vascular_smooth0.41417141
161MP0005248_abnormal_Harderian_gland0.41356445
162MP0001764_abnormal_homeostasis0.40518782
163MP0000604_amyloidosis0.39973676
164MP0001970_abnormal_pain_threshold0.39712015
165MP0002557_abnormal_social/conspecific_i0.39589303
166MP0003075_altered_response_to0.39576313
167MP0001533_abnormal_skeleton_physiology0.39286800
168MP0009840_abnormal_foam_cell0.39095237
169MP0002933_joint_inflammation0.38705607
170MP0003890_abnormal_embryonic-extraembry0.38416950
171MP0003385_abnormal_body_wall0.38283356
172MP0004859_abnormal_synaptic_plasticity0.36579738
173MP0001119_abnormal_female_reproductive0.36301769
174MP0002734_abnormal_mechanical_nocicepti0.35542227
175MP0002272_abnormal_nervous_system0.34827752
176MP0002067_abnormal_sensory_capabilities0.34545305
177MP0002133_abnormal_respiratory_system0.33967986

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.67042439
2Abnormal respiratory motile cilium morphology (HP:0005938)8.36227876
3Abnormal respiratory epithelium morphology (HP:0012253)8.36227876
4Rhinitis (HP:0012384)7.86435559
5Abnormal ciliary motility (HP:0012262)6.92961111
6Eczematoid dermatitis (HP:0000976)6.84683071
7Chronic bronchitis (HP:0004469)6.59350522
8Myositis (HP:0100614)6.42536496
9Orchitis (HP:0100796)6.25379802
10Recurrent abscess formation (HP:0002722)6.21690994
11Nasal polyposis (HP:0100582)6.06368755
12Recurrent bacterial skin infections (HP:0005406)6.03429745
13Infertility (HP:0000789)5.74891102
14Abnormality of macrophages (HP:0004311)5.46597122
15Stomatitis (HP:0010280)5.28912762
16Recurrent gram-negative bacterial infections (HP:0005420)5.10096222
17Abnormality of the nasal mucosa (HP:0000433)5.03263506
18Elevated erythrocyte sedimentation rate (HP:0003565)4.86360602
19Gastrointestinal infarctions (HP:0005244)4.45839514
20Keratoconjunctivitis sicca (HP:0001097)4.37431215
21Hypochromic microcytic anemia (HP:0004840)4.36956833
22Chronic obstructive pulmonary disease (HP:0006510)4.25685759
23Obstructive lung disease (HP:0006536)4.25685759
24Mediastinal lymphadenopathy (HP:0100721)4.21005355
25Recurrent fungal infections (HP:0002841)4.18712332
26Meningitis (HP:0001287)4.09117350
27Bronchiectasis (HP:0002110)4.06491795
28Nephronophthisis (HP:0000090)4.06416280
29Abnormal delayed hypersensitivity skin test (HP:0002963)4.06317464
30Keratoconjunctivitis (HP:0001096)4.04448418
31Recurrent skin infections (HP:0001581)3.99489078
32Encephalitis (HP:0002383)3.91875168
33Spontaneous hematomas (HP:0007420)3.89011839
34Bronchitis (HP:0012387)3.73738577
35Gingivitis (HP:0000230)3.70461016
36Increased IgE level (HP:0003212)3.69401610
37Urticaria (HP:0001025)3.68035850
38Chronic mucocutaneous candidiasis (HP:0002728)3.60294279
39Recurrent cutaneous fungal infections (HP:0011370)3.60294279
40Vasculitis (HP:0002633)3.56565519
41Hypochromic anemia (HP:0001931)3.54620367
42Peritonitis (HP:0002586)3.51464757
43Prolonged bleeding time (HP:0003010)3.50320715
44Episodic fever (HP:0001954)3.38312212
45Chest pain (HP:0100749)3.34594451
46Gingival bleeding (HP:0000225)3.27101566
47Hemoptysis (HP:0002105)3.20176753
48Arterial thrombosis (HP:0004420)3.18901836
49Cellulitis (HP:0100658)3.17648851
50Anorexia (HP:0002039)3.14192918
51Abnormality of the renal medulla (HP:0100957)3.05493341
52Pulmonary infiltrates (HP:0002113)2.97286733
53Sensory axonal neuropathy (HP:0003390)2.93599537
54Recurrent otitis media (HP:0000403)2.92854826
55Leukocytosis (HP:0001974)2.92088495
56T lymphocytopenia (HP:0005403)2.90714002
57Renovascular hypertension (HP:0100817)2.90202522
58Pulmonary embolism (HP:0002204)2.89492540
59Amyloidosis (HP:0011034)2.87478605
60Epistaxis (HP:0000421)2.86153261
61Abnormality of T cell number (HP:0011839)2.84741242
62Recurrent sinusitis (HP:0011108)2.82922159
63Gonadotropin excess (HP:0000837)2.82612882
64Gangrene (HP:0100758)2.63444966
65Overriding aorta (HP:0002623)2.63391930
66Abnormality of the peritoneum (HP:0002585)2.63389265
67Microcytic anemia (HP:0001935)2.62517297
68Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.58973998
69Inflammation of the large intestine (HP:0002037)2.58283653
70Petechiae (HP:0000967)2.57600555
71Abnormality of T cells (HP:0002843)2.57118949
72Elfin facies (HP:0004428)2.56998278
73Abnormal spermatogenesis (HP:0008669)2.56923296
74Retinal atrophy (HP:0001105)2.55562960
75Osteomyelitis (HP:0002754)2.55383517
76Abnormality of the pleura (HP:0002103)2.53411908
77Increased IgM level (HP:0003496)2.51826255
78Toxemia of pregnancy (HP:0100603)2.51146838
79Granulocytopenia (HP:0001913)2.51081222
80Hyperacusis (HP:0010780)2.50906680
81Gastrointestinal inflammation (HP:0004386)2.47128068
82Medial flaring of the eyebrow (HP:0010747)2.46686288
83Recurrent viral infections (HP:0004429)2.45797667
84Tubular atrophy (HP:0000092)2.45152759
85Sepsis (HP:0100806)2.43525574
86Short femoral neck (HP:0100864)2.39983001
87Cerebellar dysplasia (HP:0007033)2.39535591
88Fibular hypoplasia (HP:0003038)2.38590954
89Abnormality of the endocardium (HP:0004306)2.32864695
90Azoospermia (HP:0000027)2.28758888
91Metaphyseal cupping (HP:0003021)2.28355749
92Abnormality of T cell physiology (HP:0011840)2.27593398
93Type II lissencephaly (HP:0007260)2.25626080
94Glomerulopathy (HP:0100820)2.24669067
95Pustule (HP:0200039)2.23274910
96Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.22867903
97Panhypogammaglobulinemia (HP:0003139)2.22397769
98Male infertility (HP:0003251)2.22029763
99Renal dysplasia (HP:0000110)2.21431400
100Chronic sinusitis (HP:0011109)2.20615553
101Hypergammaglobulinemia (HP:0010702)2.18857418
102Difficulty running (HP:0009046)2.17991369
103Keratitis (HP:0000491)2.17483337
104Abnormal platelet volume (HP:0011876)2.17288731
105Retinal dysplasia (HP:0007973)2.16247176
106Premature loss of primary teeth (HP:0006323)2.14176600
107Vertigo (HP:0002321)2.13743309
108Eosinophilia (HP:0001880)2.10989070
109Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.09988041
110Flat cornea (HP:0007720)2.09151995
111Skin ulcer (HP:0200042)2.08982852
112Acne (HP:0001061)2.08917480
113Abnormality of the pericardium (HP:0001697)2.08260924
114Lymphopenia (HP:0001888)2.07348598
115Amyotrophic lateral sclerosis (HP:0007354)2.06944253
116Molar tooth sign on MRI (HP:0002419)2.06481370
117Abnormality of midbrain morphology (HP:0002418)2.06481370
118Microglossia (HP:0000171)2.06030834
119Acute hepatic failure (HP:0006554)2.04890084
120Renal duplication (HP:0000075)2.04725041
121Slow saccadic eye movements (HP:0000514)2.03370071
122Subacute progressive viral hepatitis (HP:0006572)2.01607992
123Abnormality of cells of the lymphoid lineage (HP:0012140)2.00868621
124Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.5403496
125Absent/shortened dynein arms (HP:0200106)11.2307526
126Dynein arm defect of respiratory motile cilia (HP:0012255)11.2307526
127Spastic tetraparesis (HP:0001285)1.99398606
128Hypoplasia of the capital femoral epiphysis (HP:0003090)1.98893359
129Abnormality of the heme biosynthetic pathway (HP:0010472)1.98627355
130Tubulointerstitial abnormality (HP:0001969)1.97952305
131Purpura (HP:0000979)1.97548962
132Polycythemia (HP:0001901)1.97422790
133Polygenic inheritance (HP:0010982)1.96915372
134Chronic otitis media (HP:0000389)1.96779730
135Hepatosplenomegaly (HP:0001433)1.96033999
136Insomnia (HP:0100785)1.95584845
137Cheilitis (HP:0100825)1.93772658
138Abnormality of the lower motor neuron (HP:0002366)1.93644974
139Megalocornea (HP:0000485)1.93492262
140Tubulointerstitial nephritis (HP:0001970)1.92003814
141Absent frontal sinuses (HP:0002688)1.91566053
142Thrombophlebitis (HP:0004418)1.90779213
143Viral hepatitis (HP:0006562)1.89918189
144Skin rash (HP:0000988)1.87210959
145Segmental peripheral demyelination/remyelination (HP:0003481)1.87210922
146Absent epiphyses (HP:0010577)1.84660547
147Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.84660547
148Recurrent bronchitis (HP:0002837)1.83330613
149Abnormality of iron homeostasis (HP:0011031)1.82691066
150Recurrent pneumonia (HP:0006532)1.81933167
151Colitis (HP:0002583)1.81291268
152Tubulointerstitial fibrosis (HP:0005576)1.80446043
153Polyneuropathy (HP:0001271)1.80089837
154Hypermelanotic macule (HP:0001034)1.79928283
155Postaxial foot polydactyly (HP:0001830)1.77647783
156Increased serum ferritin (HP:0003281)1.77109670
157Occipital encephalocele (HP:0002085)1.75849193
158Aplasia/hypoplasia of the femur (HP:0005613)1.74894166
159Stage 5 chronic kidney disease (HP:0003774)1.74619284
160Autoimmune hemolytic anemia (HP:0001890)1.74216920
161Gait imbalance (HP:0002141)1.68160657
162Neurofibrillary tangles (HP:0002185)1.67912197
163Impulsivity (HP:0100710)1.64567971
164Congenital primary aphakia (HP:0007707)1.61470782
165Spinal rigidity (HP:0003306)1.60135805
166Abnormal hair whorl (HP:0010721)1.58382049
167Hyporeflexia of lower limbs (HP:0002600)1.51580246
168Bell-shaped thorax (HP:0001591)1.51563543
169Congenital hepatic fibrosis (HP:0002612)1.50995097
170Aplasia/Hypoplasia of the fibula (HP:0006492)1.49604610
171Median cleft lip (HP:0000161)1.49484980
172Oculomotor apraxia (HP:0000657)1.49305396
173Abnormality of the renal cortex (HP:0011035)1.48538605
174Postaxial hand polydactyly (HP:0001162)1.47072801
175Nephrogenic diabetes insipidus (HP:0009806)1.46349074
176Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.46218769
177Abnormality of the diencephalon (HP:0010662)1.45735935
178Easy fatigability (HP:0003388)1.45473995
179Short ribs (HP:0000773)1.44996834
180Lissencephaly (HP:0001339)1.43599282
181Papillary thyroid carcinoma (HP:0002895)1.43033054
182Buphthalmos (HP:0000557)1.42523171
183Short thorax (HP:0010306)1.41489109
184Retrobulbar optic neuritis (HP:0100654)1.40563916
185Optic neuritis (HP:0100653)1.40563916
186Abnormality of molar (HP:0011077)1.40080676
187Abnormality of molar morphology (HP:0011070)1.40080676
188Abnormality of ocular smooth pursuit (HP:0000617)1.39673802
189Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.38659376
190J-shaped sella turcica (HP:0002680)1.37796734
191Large eyes (HP:0001090)1.37660296
192Abnormal drinking behavior (HP:0030082)1.37314635
193Polydipsia (HP:0001959)1.37314635
194Upper motor neuron abnormality (HP:0002127)1.36783184
195Aplasia/Hypoplasia of the lens (HP:0008063)1.36154100
196Taurodontia (HP:0000679)1.35954617
197Abnormality of permanent molar morphology (HP:0011071)1.35954617

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.57921818
2PDK38.57921818
3PDK25.40784103
4TESK13.98300514
5PRKD33.66795024
6IRAK43.58574544
7MAP2K33.53860315
8PNCK3.24788360
9MAP4K13.20947932
10BLK3.09703844
11ICK2.52639826
12GRK62.39310543
13PTK2B2.31635053
14BMPR1B1.99874551
15TXK1.86830210
16WNK41.78920675
17PRPF4B1.71891539
18STK391.67501122
19JAK31.67467543
20JAK21.63629361
21CASK1.61759559
22MAP3K111.59281191
23KSR21.56382946
24SYK1.56147085
25CCNB11.55683891
26IKBKE1.46632182
27MAP3K61.46549250
28YES11.41002506
29LYN1.39197022
30SIK31.26199963
31TAOK31.21872891
32JAK11.19689501
33NTRK21.14020594
34MAP3K91.13913027
35STK381.12115718
36NEK21.10738889
37MAP3K21.09986032
38LCK1.06751725
39MATK1.06125351
40CAMK1G1.03827892
41KIT1.02639392
42MAP3K130.99040557
43MAP2K40.98889868
44PTK60.97797792
45MAPK150.95576163
46TYK20.95517418
47IRAK10.93115321
48ITK0.92714622
49CDK190.88598860
50PRKD20.86590779
51BMPR20.84726103
52MAP3K50.82683853
53TAOK20.80464083
54EPHA30.79950849
55FES0.78327050
56LRRK20.77217038
57GRK70.74548043
58PIK3CG0.72685111
59PDPK10.72236128
60FGFR30.68828489
61FYN0.67682876
62WNK10.67201380
63AKT30.66579587
64RAF10.65628589
65PDK10.65577213
66CSK0.64437337
67TESK20.64051170
68TRIB30.63469751
69SIK20.62334247
70KSR10.61693571
71IKBKB0.60835218
72IRAK20.60275400
73RET0.59744438
74TGFBR20.58523576
75MAP3K70.57607619
76HCK0.55694115
77STK30.55660657
78MAP3K30.55187995
79EPHB10.54501560
80GRK10.52987053
81HIPK20.51820682
82SMG10.51290313
83FGFR40.50806015
84MARK30.49913076
85NLK0.49061738
86DYRK1B0.47794604
87MAPK120.47720810
88PDGFRB0.47020952
89CDC42BPA0.46837980
90DAPK20.45526800
91RPS6KB10.45310950
92PRKCG0.44950151
93FGR0.43765848
94CAMKK10.42457708
95TYRO30.42212784
96DYRK30.42092075
97PRKCQ0.41169014
98MAP2K70.40691501
99STK110.40310823
100INSRR0.40048652
101MAP3K140.39871181
102RPS6KC10.38875964
103RPS6KL10.38875964
104CLK10.38085901
105MARK10.36756267
106PIM10.36704363
107ERBB30.36640747
108TEC0.36600277
109PRKCZ0.36191920
110PRKG10.34429271
111MARK20.34378969
112ALK0.33888913
113BTK0.33547807
114RPS6KA60.32904129
115CHEK20.32719198
116EGFR0.32608919
117PRKG20.31399368
118RIPK40.31159286
119STK100.30536149
120ERBB40.30312271
121MAP2K60.30126110
122PRKCD0.29571275
123GRK50.28994631
124MAP3K10.28250782
125TAOK10.27634678
126SGK20.27107780
127CDK90.26222900
128PRKD10.26002136
129TNK20.25446377
130PRKAA10.24894213
131PINK10.24417786
132PASK0.24410205
133CSF1R0.24369547
134CAMK10.22279682
135CHEK10.22123081
136INSR0.22060260
137PKN10.21416172
138SGK2230.17825696
139SGK4940.17825696
140MUSK0.16309499
141DDR20.15368357
142PRKACG0.14300276
143TBK10.13988588
144ERN10.12331278
145SGK30.11790812
146IRAK30.11707179
147BRAF0.11658562
148ATM0.11493632
149PLK40.11441817
150EIF2AK20.10514971
151PRKACB0.10499023
152PAK10.10337821
153ATR0.09687210
154TNIK0.09350227
155MAPKAPK20.08158474
156CAMK2A0.07381497
157NEK60.07309725
158SGK10.06107691
159MAPK40.05455704
160MAPK70.04513961
161CSNK1A1L0.04412344
162ZAP700.04233022

Predicted pathways (KEGG)

RankGene SetZ-score
1Dorso-ventral axis formation_Homo sapiens_hsa043203.56596649
2Selenocompound metabolism_Homo sapiens_hsa004503.39451589
3Pentose phosphate pathway_Homo sapiens_hsa000303.08423454
4Pyruvate metabolism_Homo sapiens_hsa006202.69375120
5Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.65861050
6Fatty acid biosynthesis_Homo sapiens_hsa000612.41951534
7Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.33349724
8Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.26237558
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.25894185
10Toll-like receptor signaling pathway_Homo sapiens_hsa046202.19672155
11NOD-like receptor signaling pathway_Homo sapiens_hsa046212.18368620
12Linoleic acid metabolism_Homo sapiens_hsa005912.16502561
13Vitamin B6 metabolism_Homo sapiens_hsa007502.13787426
14Basal transcription factors_Homo sapiens_hsa030222.07641802
15Glucagon signaling pathway_Homo sapiens_hsa049222.03703039
16Huntingtons disease_Homo sapiens_hsa050161.89019042
17Measles_Homo sapiens_hsa051621.87448975
18Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.81286124
19Graft-versus-host disease_Homo sapiens_hsa053321.80533903
20Acute myeloid leukemia_Homo sapiens_hsa052211.78939207
21Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.78262864
22Chemokine signaling pathway_Homo sapiens_hsa040621.77331413
23Glycosaminoglycan degradation_Homo sapiens_hsa005311.75667793
24Allograft rejection_Homo sapiens_hsa053301.71579592
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.71268102
26Primary immunodeficiency_Homo sapiens_hsa053401.66786094
27Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.64733584
28Ether lipid metabolism_Homo sapiens_hsa005651.62269945
29Hematopoietic cell lineage_Homo sapiens_hsa046401.59606782
30Amphetamine addiction_Homo sapiens_hsa050311.58474217
31Renin secretion_Homo sapiens_hsa049241.56053238
32Collecting duct acid secretion_Homo sapiens_hsa049661.56047049
33NF-kappa B signaling pathway_Homo sapiens_hsa040641.55975495
34Influenza A_Homo sapiens_hsa051641.55729275
35T cell receptor signaling pathway_Homo sapiens_hsa046601.52645981
36Toxoplasmosis_Homo sapiens_hsa051451.49292348
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.45947381
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.45342728
39Staphylococcus aureus infection_Homo sapiens_hsa051501.41192747
40Propanoate metabolism_Homo sapiens_hsa006401.41050063
41Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.40214602
42Fanconi anemia pathway_Homo sapiens_hsa034601.38967236
43TNF signaling pathway_Homo sapiens_hsa046681.37753281
44Synaptic vesicle cycle_Homo sapiens_hsa047211.36859002
45Glycerophospholipid metabolism_Homo sapiens_hsa005641.35073012
46Glycerolipid metabolism_Homo sapiens_hsa005611.33617463
47Nicotine addiction_Homo sapiens_hsa050331.32084907
48Leukocyte transendothelial migration_Homo sapiens_hsa046701.31322007
49Fructose and mannose metabolism_Homo sapiens_hsa000511.30837676
50Non-small cell lung cancer_Homo sapiens_hsa052231.29874821
51Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.26249058
52Antigen processing and presentation_Homo sapiens_hsa046121.26132400
53Herpes simplex infection_Homo sapiens_hsa051681.25925826
54Hepatitis B_Homo sapiens_hsa051611.24512627
55Platelet activation_Homo sapiens_hsa046111.24244354
56Hepatitis C_Homo sapiens_hsa051601.18583847
57Legionellosis_Homo sapiens_hsa051341.17101314
58Viral myocarditis_Homo sapiens_hsa054161.15236131
59Arachidonic acid metabolism_Homo sapiens_hsa005901.12030419
60Pancreatic cancer_Homo sapiens_hsa052121.09172127
61Pertussis_Homo sapiens_hsa051331.08973584
62Shigellosis_Homo sapiens_hsa051311.08638258
63Oocyte meiosis_Homo sapiens_hsa041141.08311952
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.06767880
65Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.05967938
66Carbohydrate digestion and absorption_Homo sapiens_hsa049731.05259474
67VEGF signaling pathway_Homo sapiens_hsa043701.03210831
68Sulfur metabolism_Homo sapiens_hsa009201.01617854
69Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01392588
70Chronic myeloid leukemia_Homo sapiens_hsa052201.01391849
71Cardiac muscle contraction_Homo sapiens_hsa042601.00880415
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.99306264
73Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.96870944
74Prolactin signaling pathway_Homo sapiens_hsa049170.96295618
75Circadian entrainment_Homo sapiens_hsa047130.93155487
76Apoptosis_Homo sapiens_hsa042100.93036591
77Renal cell carcinoma_Homo sapiens_hsa052110.90723557
78Cysteine and methionine metabolism_Homo sapiens_hsa002700.90713884
79Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.90708789
80Calcium signaling pathway_Homo sapiens_hsa040200.90166530
81Long-term potentiation_Homo sapiens_hsa047200.88014789
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.87409301
83Taste transduction_Homo sapiens_hsa047420.85182906
84Rheumatoid arthritis_Homo sapiens_hsa053230.84175594
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.83591839
86Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.83411250
87Estrogen signaling pathway_Homo sapiens_hsa049150.82524333
88Morphine addiction_Homo sapiens_hsa050320.82096857
89Type I diabetes mellitus_Homo sapiens_hsa049400.81356111
90Phagosome_Homo sapiens_hsa041450.79744574
91FoxO signaling pathway_Homo sapiens_hsa040680.79605612
92Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.77672534
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76677449
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.76046781
95AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.75679500
96Amoebiasis_Homo sapiens_hsa051460.75660206
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.75300070
98Carbon metabolism_Homo sapiens_hsa012000.74727850
99PPAR signaling pathway_Homo sapiens_hsa033200.74548945
100Endocytosis_Homo sapiens_hsa041440.74312082
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.74247160
102Intestinal immune network for IgA production_Homo sapiens_hsa046720.71637538
103Other glycan degradation_Homo sapiens_hsa005110.71450515
104Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.71255054
105Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.70646585
106Gastric acid secretion_Homo sapiens_hsa049710.69823881
107Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69808293
108Endometrial cancer_Homo sapiens_hsa052130.69451511
109Notch signaling pathway_Homo sapiens_hsa043300.68614365
110Choline metabolism in cancer_Homo sapiens_hsa052310.66446982
111GnRH signaling pathway_Homo sapiens_hsa049120.63665916
112Malaria_Homo sapiens_hsa051440.63592651
113Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63501479
114Viral carcinogenesis_Homo sapiens_hsa052030.63318562
115Olfactory transduction_Homo sapiens_hsa047400.62059449
116Biosynthesis of amino acids_Homo sapiens_hsa012300.61715980
117Long-term depression_Homo sapiens_hsa047300.61399469
118Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61148511
119Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60925290
120cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60922999
121Glutamatergic synapse_Homo sapiens_hsa047240.60711145
122HIF-1 signaling pathway_Homo sapiens_hsa040660.58891477
123Sphingolipid metabolism_Homo sapiens_hsa006000.58009495
124Type II diabetes mellitus_Homo sapiens_hsa049300.57207901
125Epstein-Barr virus infection_Homo sapiens_hsa051690.55869807
126Insulin resistance_Homo sapiens_hsa049310.53874430
127Regulation of autophagy_Homo sapiens_hsa041400.53757681
128Colorectal cancer_Homo sapiens_hsa052100.53290297
129Salivary secretion_Homo sapiens_hsa049700.52566468
130Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.51812920
131Adipocytokine signaling pathway_Homo sapiens_hsa049200.51548479
132N-Glycan biosynthesis_Homo sapiens_hsa005100.51421246
133Vascular smooth muscle contraction_Homo sapiens_hsa042700.50793664
134Rap1 signaling pathway_Homo sapiens_hsa040150.50637457
135Mineral absorption_Homo sapiens_hsa049780.50466505
136Cocaine addiction_Homo sapiens_hsa050300.49597909
137Fat digestion and absorption_Homo sapiens_hsa049750.49529867
138Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49127145
139mTOR signaling pathway_Homo sapiens_hsa041500.49092303
140Lysosome_Homo sapiens_hsa041420.48693735
141ErbB signaling pathway_Homo sapiens_hsa040120.48466508
142Osteoclast differentiation_Homo sapiens_hsa043800.48456661
143Inositol phosphate metabolism_Homo sapiens_hsa005620.46881607
144SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44528632
145MAPK signaling pathway_Homo sapiens_hsa040100.44417135
146cAMP signaling pathway_Homo sapiens_hsa040240.44026193
147Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43811272
148Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43726153
149Salmonella infection_Homo sapiens_hsa051320.43653164
150Tuberculosis_Homo sapiens_hsa051520.42339651
151Autoimmune thyroid disease_Homo sapiens_hsa053200.42070006
152Insulin secretion_Homo sapiens_hsa049110.42002688
153Hedgehog signaling pathway_Homo sapiens_hsa043400.41737404
154GABAergic synapse_Homo sapiens_hsa047270.41202340
155HTLV-I infection_Homo sapiens_hsa051660.40932294
156Prostate cancer_Homo sapiens_hsa052150.40884248
157Oxytocin signaling pathway_Homo sapiens_hsa049210.40503620
158B cell receptor signaling pathway_Homo sapiens_hsa046620.40133780
159Leishmaniasis_Homo sapiens_hsa051400.38884976
160Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.38175246
161Oxidative phosphorylation_Homo sapiens_hsa001900.37968467
162Systemic lupus erythematosus_Homo sapiens_hsa053220.36946287
163Alzheimers disease_Homo sapiens_hsa050100.36840908
164Alcoholism_Homo sapiens_hsa050340.33373925
165African trypanosomiasis_Homo sapiens_hsa051430.33279103
166Asthma_Homo sapiens_hsa053100.32813544
167Purine metabolism_Homo sapiens_hsa002300.31463267
168Fatty acid metabolism_Homo sapiens_hsa012120.30733038
169Jak-STAT signaling pathway_Homo sapiens_hsa046300.29065179
170Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.28128774

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