PROKR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor for prokineticins. The encoded protein is similar in sequence to GPR73, another G protein-coupled receptor for prokineticins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1gamma-aminobutyric acid transport (GO:0015812)6.42380542
2axonal fasciculation (GO:0007413)5.76305205
3neuronal action potential propagation (GO:0019227)5.61159813
4protein localization to synapse (GO:0035418)5.03839212
5vesicle transport along microtubule (GO:0047496)4.96423839
6synaptic vesicle maturation (GO:0016188)4.87391879
7regulation of synaptic vesicle exocytosis (GO:2000300)4.83933060
8pyrimidine nucleobase catabolic process (GO:0006208)4.80614835
9synaptic transmission, glutamatergic (GO:0035249)4.59725018
10glutamate secretion (GO:0014047)4.54662219
11neurotransmitter secretion (GO:0007269)4.48630463
12neuron recognition (GO:0008038)4.31973806
13glutamate receptor signaling pathway (GO:0007215)4.26753596
14polyketide metabolic process (GO:0030638)4.13119478
15doxorubicin metabolic process (GO:0044598)4.13119478
16daunorubicin metabolic process (GO:0044597)4.13119478
17organelle transport along microtubule (GO:0072384)4.01062841
18cAMP catabolic process (GO:0006198)3.99623971
19nucleobase catabolic process (GO:0046113)3.97299388
20glycine transport (GO:0015816)3.96892312
21exploration behavior (GO:0035640)3.92969915
22neuronal ion channel clustering (GO:0045161)3.91570608
23synaptic vesicle exocytosis (GO:0016079)3.88631604
24regulation of short-term neuronal synaptic plasticity (GO:0048172)3.87551059
25synaptic vesicle docking involved in exocytosis (GO:0016081)3.85859465
26cerebral cortex radially oriented cell migration (GO:0021799)3.85377895
27neuromuscular synaptic transmission (GO:0007274)3.84997434
28regulation of activation of Janus kinase activity (GO:0010533)3.80454144
29superoxide anion generation (GO:0042554)3.79887065
30paraxial mesoderm development (GO:0048339)3.76820547
31regulation of synaptic vesicle transport (GO:1902803)3.75830918
32positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.74291801
33mitochondrion distribution (GO:0048311)3.67835381
34cyclic nucleotide catabolic process (GO:0009214)3.62730901
35regulation of dendritic cell antigen processing and presentation (GO:0002604)3.60055857
36G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.57076915
37neuron-neuron synaptic transmission (GO:0007270)3.55934878
38locomotory exploration behavior (GO:0035641)3.53954235
39regulation of neurotransmitter levels (GO:0001505)3.52077441
40gamma-aminobutyric acid signaling pathway (GO:0007214)3.48691876
41synapse assembly (GO:0007416)3.42575099
42regulation of cell communication by electrical coupling (GO:0010649)3.40552999
43regulation of fever generation (GO:0031620)3.37240596
44neurotransmitter transport (GO:0006836)3.32399411
45postsynaptic membrane organization (GO:0001941)3.31237102
46positive regulation of heat generation (GO:0031652)3.31089917
47presynaptic membrane assembly (GO:0097105)3.29598807
48protein insertion into membrane (GO:0051205)3.28980259
49branching involved in prostate gland morphogenesis (GO:0060442)3.27996806
50mechanosensory behavior (GO:0007638)3.27285165
51positive regulation of cellular amide metabolic process (GO:0034250)3.26423352
52positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.26018421
53energy homeostasis (GO:0097009)3.23448132
54mesenchymal cell differentiation involved in kidney development (GO:0072161)3.22437509
55mesenchymal cell differentiation involved in renal system development (GO:2001012)3.22437509
56regulation of synapse assembly (GO:0051963)3.19171737
57G-protein coupled receptor internalization (GO:0002031)3.16042370
58positive regulation of synapse assembly (GO:0051965)3.13242701
59positive regulation of antigen processing and presentation (GO:0002579)3.12014404
60regulation of voltage-gated calcium channel activity (GO:1901385)3.09778751
61L-serine transport (GO:0015825)3.09762182
62fucosylation (GO:0036065)3.08556857
63fucose catabolic process (GO:0019317)3.08546413
64L-fucose metabolic process (GO:0042354)3.08546413
65L-fucose catabolic process (GO:0042355)3.08546413
66opioid receptor signaling pathway (GO:0038003)3.08331601
67negative regulation of heart rate (GO:0010459)3.08308495
68negative regulation of keratinocyte proliferation (GO:0010839)3.05615774
69auditory behavior (GO:0031223)3.04082757
70membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.03039918
71positive regulation of interleukin-1 beta secretion (GO:0050718)3.02245699
72negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.98926027
73negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.93374659
74activation of protein kinase A activity (GO:0034199)2.93202712
75long-term memory (GO:0007616)2.93157840
76protein-cofactor linkage (GO:0018065)2.90136501
77positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.89978008
78growth hormone secretion (GO:0030252)2.87263589
79rRNA catabolic process (GO:0016075)2.84494208
80short-term memory (GO:0007614)2.83831181
81cGMP metabolic process (GO:0046068)2.81863641
82regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.81592764
83epithelial cell differentiation involved in kidney development (GO:0035850)2.81140161
84cell migration in hindbrain (GO:0021535)2.78217152
85regulation of neurotransmitter secretion (GO:0046928)2.77986184
86DNA double-strand break processing (GO:0000729)2.77864150
87detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.77760411
88detection of other organism (GO:0098543)2.77144326
89regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.76875978
90regulation of synaptic transmission, glutamatergic (GO:0051966)2.76655211
91negative regulation of mast cell activation (GO:0033004)2.76593687
92regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.75827500
93positive regulation of interleukin-1 secretion (GO:0050716)2.75674919
94DNA integration (GO:0015074)2.74548310
95microtubule nucleation (GO:0007020)2.74425103
96auditory receptor cell stereocilium organization (GO:0060088)2.74194027
97regulation of excitatory postsynaptic membrane potential (GO:0060079)2.73942141
98retinal cone cell development (GO:0046549)2.73751256
99presynaptic membrane organization (GO:0097090)2.72768228
100glycosphingolipid biosynthetic process (GO:0006688)2.72685969
101regulation of heat generation (GO:0031650)2.71994753
102hippocampus development (GO:0021766)2.70266423
103positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.69918327
104vesicle localization (GO:0051648)2.69791933
105positive regulation of uterine smooth muscle contraction (GO:0070474)2.68299912
106cardiac ventricle formation (GO:0003211)2.67603231
107regulation of antigen processing and presentation (GO:0002577)2.66607888
108positive regulation of synapse maturation (GO:0090129)2.66121232
109substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.65798358
110substrate-independent telencephalic tangential migration (GO:0021826)2.65798358
111cAMP metabolic process (GO:0046058)2.65634723
112regulation of interleukin-1 beta secretion (GO:0050706)2.64294667
113detection of bacterium (GO:0016045)2.64003627
114regulation of vesicle fusion (GO:0031338)2.63944623
115dentate gyrus development (GO:0021542)2.63637167
116cell differentiation involved in metanephros development (GO:0072202)2.63253045
117cellular response to exogenous dsRNA (GO:0071360)2.63015987
118regulation of non-canonical Wnt signaling pathway (GO:2000050)2.61892052
119regulation of cardiac muscle cell contraction (GO:0086004)2.61633377
120positive regulation of membrane potential (GO:0045838)2.60705003
121dendritic cell chemotaxis (GO:0002407)2.60512490
122establishment of mitochondrion localization (GO:0051654)2.59599208
123inner ear receptor stereocilium organization (GO:0060122)2.59226998
124synaptic transmission (GO:0007268)2.58852439
125regulation of relaxation of muscle (GO:1901077)2.58626302
126detection of molecule of bacterial origin (GO:0032490)2.56854745
127interferon-gamma production (GO:0032609)2.56611296
128negative regulation of homotypic cell-cell adhesion (GO:0034111)2.55396567
129positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.55169952
130vocalization behavior (GO:0071625)2.52692809
131ganglion development (GO:0061548)2.50833303
132superoxide metabolic process (GO:0006801)2.50772704
133behavioral response to nicotine (GO:0035095)2.50598219
134positive regulation of synaptic transmission, GABAergic (GO:0032230)2.50445925
135central nervous system projection neuron axonogenesis (GO:0021952)2.49794317
136positive regulation of type 2 immune response (GO:0002830)2.49085870
137positive regulation of CREB transcription factor activity (GO:0032793)2.48730274
138startle response (GO:0001964)2.48271815
139ionotropic glutamate receptor signaling pathway (GO:0035235)2.47475103
140regulation of cellular extravasation (GO:0002691)2.45921685
141negative regulation of synaptic transmission, GABAergic (GO:0032229)2.45746571
142cerebral cortex cell migration (GO:0021795)2.45364497
143neuron cell-cell adhesion (GO:0007158)2.42559316
144regulation of platelet aggregation (GO:0090330)2.41702441
145positive regulation of action potential (GO:0045760)2.41561545
146CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.40359029
147positive regulation of defense response to virus by host (GO:0002230)2.40153793
148positive regulation of monocyte chemotaxis (GO:0090026)2.39692989
149modulation by virus of host process (GO:0019054)2.39670055
150serotonin receptor signaling pathway (GO:0007210)2.37169249
151antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.35562944
152regulation of glutamate receptor signaling pathway (GO:1900449)2.33640713
153response to auditory stimulus (GO:0010996)2.33192187
154detection of external biotic stimulus (GO:0098581)2.31743621
155positive regulation of interleukin-1 beta production (GO:0032731)2.28604422
156calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.27568516
157regulation of pigment cell differentiation (GO:0050932)2.26621957
158tRNA methylation (GO:0030488)2.25328042
159aminoglycoside antibiotic metabolic process (GO:0030647)2.22675834
160modulation by symbiont of host cellular process (GO:0044068)2.22615042
161dendritic cell migration (GO:0036336)2.22329487
162female gonad development (GO:0008585)2.21970867
163histone H3-K4 trimethylation (GO:0080182)2.21521049
164CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.20049152
165T-helper cell differentiation (GO:0042093)2.20049152
166regulation of interleukin-1 secretion (GO:0050704)2.18749728
167detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.18657328
168neurotransmitter-gated ion channel clustering (GO:0072578)2.16892282
169cell proliferation in forebrain (GO:0021846)2.16467846
170regulation of memory T cell differentiation (GO:0043380)2.16464502
171proline transport (GO:0015824)2.15694452
172cell differentiation involved in kidney development (GO:0061005)2.15655125
173CD4-positive, alpha-beta T cell activation (GO:0035710)2.15641729
174cellular anion homeostasis (GO:0030002)2.15598427
175kidney morphogenesis (GO:0060993)2.15567371
176facial nerve structural organization (GO:0021612)2.15172727
177response to pheromone (GO:0019236)2.15038501
178positive regulation of interleukin-17 production (GO:0032740)2.14933444
179regulation of T-helper 1 cell differentiation (GO:0045625)2.13325103
180regulation of timing of cell differentiation (GO:0048505)2.11734091
181cellular response to gamma radiation (GO:0071480)2.11587038
182centriole assembly (GO:0098534)2.11363199
183NIK/NF-kappaB signaling (GO:0038061)2.10484680

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.09685311
2CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons4.00891802
3ZNF274_21170338_ChIP-Seq_K562_Hela3.40219204
4EZH2_22144423_ChIP-Seq_EOC_Human3.01440536
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.74402397
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.60356631
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.56769892
8SMAD_19615063_ChIP-ChIP_OVARY_Human2.47777872
9PCGF2_27294783_Chip-Seq_ESCs_Mouse2.42925242
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.40507125
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.32053229
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.28466230
13IGF1R_20145208_ChIP-Seq_DFB_Human2.27696294
14JARID2_20064375_ChIP-Seq_MESCs_Mouse2.13790812
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.06178978
16* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.04877506
17REST_18959480_ChIP-ChIP_MESCs_Mouse2.04533918
18SUZ12_27294783_Chip-Seq_NPCs_Mouse2.03006740
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.01874197
20EZH2_27304074_Chip-Seq_ESCs_Mouse2.00163913
21EED_16625203_ChIP-ChIP_MESCs_Mouse1.99397104
22CBX2_27304074_Chip-Seq_ESCs_Mouse1.99290900
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.96999208
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.96545236
25GATA1_26923725_Chip-Seq_HPCs_Mouse1.94105615
26* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.93212629
27BP1_19119308_ChIP-ChIP_Hs578T_Human1.91876918
28* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.91081973
29NFE2_27457419_Chip-Seq_LIVER_Mouse1.88866404
30PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.86925712
31PCGF2_27294783_Chip-Seq_NPCs_Mouse1.86149807
32* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.85572729
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.84275650
34P300_19829295_ChIP-Seq_ESCs_Human1.82410035
35CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.81993140
36SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.80813090
37* NANOG_18555785_Chip-Seq_ESCs_Mouse1.80318094
38* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.80053223
39TAF15_26573619_Chip-Seq_HEK293_Human1.78743085
40BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.77934559
41* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.74812894
42* E2F1_18555785_Chip-Seq_ESCs_Mouse1.73783361
43VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.72644553
44RNF2_27304074_Chip-Seq_NSC_Mouse1.71025485
45* P53_22387025_ChIP-Seq_ESCs_Mouse1.69474195
46* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.68601846
47* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.67297724
48SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.66785946
49SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.65097659
50VDR_22108803_ChIP-Seq_LS180_Human1.62757586
51EZH2_27294783_Chip-Seq_NPCs_Mouse1.62579767
52RNF2_27304074_Chip-Seq_ESCs_Mouse1.60235664
53* STAT3_18555785_Chip-Seq_ESCs_Mouse1.60209013
54* CMYC_18555785_Chip-Seq_ESCs_Mouse1.58766510
55* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.56965492
56* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.56965492
57* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.54617490
58SMAD4_21799915_ChIP-Seq_A2780_Human1.53180561
59* NMYC_18555785_Chip-Seq_ESCs_Mouse1.52936690
60CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51276718
61RARB_27405468_Chip-Seq_BRAIN_Mouse1.51069268
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.50893029
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.50778984
64ER_23166858_ChIP-Seq_MCF-7_Human1.49793602
65IKZF1_21737484_ChIP-ChIP_HCT116_Human1.48532767
66CTBP2_25329375_ChIP-Seq_LNCAP_Human1.48232830
67* P300_18555785_Chip-Seq_ESCs_Mouse1.46740959
68POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.46166872
69TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46166872
70RUNX1_27457419_Chip-Seq_LIVER_Mouse1.44828549
71SUZ12_27294783_Chip-Seq_ESCs_Mouse1.44594123
72RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.44277374
73EZH2_27294783_Chip-Seq_ESCs_Mouse1.44065777
74* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43665079
75* SOX2_18555785_Chip-Seq_ESCs_Mouse1.43646694
76* OCT4_18555785_Chip-Seq_ESCs_Mouse1.41267699
77DROSHA_22980978_ChIP-Seq_HELA_Human1.38814308
78* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.38342572
79PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.37596668
80E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.37186691
81* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.36685322
82PU1_27457419_Chip-Seq_LIVER_Mouse1.36399515
83* ZFX_18555785_Chip-Seq_ESCs_Mouse1.34513036
84TP53_18474530_ChIP-ChIP_U2OS_Human1.34169751
85AR_21572438_ChIP-Seq_LNCaP_Human1.33716873
86FUS_26573619_Chip-Seq_HEK293_Human1.33643390
87* CTCF_18555785_Chip-Seq_ESCs_Mouse1.32252069
88* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.31469228
89TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30503805
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29894308
91CBP_20019798_ChIP-Seq_JUKART_Human1.29894308
92KLF5_20875108_ChIP-Seq_MESCs_Mouse1.29560772
93* KLF4_18555785_Chip-Seq_ESCs_Mouse1.28569984
94AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28487248
95WT1_19549856_ChIP-ChIP_CCG9911_Human1.28195158
96* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.28183813
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27086055
98REST_21632747_ChIP-Seq_MESCs_Mouse1.25509831
99AR_25329375_ChIP-Seq_VCAP_Human1.24287446
100RBPJ_22232070_ChIP-Seq_NCS_Mouse1.24147360
101STAT3_23295773_ChIP-Seq_U87_Human1.22980502
102SMAD3_21741376_ChIP-Seq_EPCs_Human1.21015062
103RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.20745614
104* SMAD1_18555785_Chip-Seq_ESCs_Mouse1.20405614
105MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20144380
106SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.19845544
107SOX2_21211035_ChIP-Seq_LN229_Gbm1.19813665
108CDX2_19796622_ChIP-Seq_MESCs_Mouse1.19711477
109CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19220522
110HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.18100948
111TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.18086940
112TAL1_26923725_Chip-Seq_HPCs_Mouse1.16943342
113TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16304473
114* TCF4_23295773_ChIP-Seq_U87_Human1.16025969
115CTBP1_25329375_ChIP-Seq_LNCAP_Human1.15397475
116P53_22127205_ChIP-Seq_FIBROBLAST_Human1.15382441
117TP63_19390658_ChIP-ChIP_HaCaT_Human1.14822906
118EWS_26573619_Chip-Seq_HEK293_Human1.14188971
119OCT4_21477851_ChIP-Seq_ESCs_Mouse1.13957013
120KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.13443716
121KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.13443716
122KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.13443716
123IRF8_21731497_ChIP-ChIP_J774_Mouse1.13235017
124NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.12197219
125* KDM2B_26808549_Chip-Seq_REH_Human1.11624175
126POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10561555
127NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09943352
128CRX_20693478_ChIP-Seq_RETINA_Mouse1.08505642
129RUNX2_22187159_ChIP-Seq_PCA_Human1.08119346
130UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07806173
131JUN_21703547_ChIP-Seq_K562_Human1.07172296
132RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.06043968
133AR_19668381_ChIP-Seq_PC3_Human1.05005631
134GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03899099
135SOX9_26525672_Chip-Seq_HEART_Mouse1.03788622
136SOX2_16153702_ChIP-ChIP_HESCs_Human1.03735598
137HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.03552654
138KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.02985780
139LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02566968
140TBX3_20139965_ChIP-Seq_ESCs_Mouse1.01172709
141POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.99993450
142TBX3_20139965_ChIP-Seq_MESCs_Mouse0.99864149
143MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98662792
144STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.93691220
145SMAD4_21741376_ChIP-Seq_EPCs_Human0.93685520

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat5.22759313
2MP0001188_hyperpigmentation3.66790068
3MP0002876_abnormal_thyroid_physiology3.58800422
4MP0001346_abnormal_lacrimal_gland3.56433666
5MP0004270_analgesia3.45929609
6MP0002822_catalepsy3.27103402
7MP0006292_abnormal_olfactory_placode2.90128759
8MP0002277_abnormal_respiratory_mucosa2.86190350
9MP0000566_synostosis2.69581314
10* MP0005645_abnormal_hypothalamus_physiol2.58401420
11MP0002653_abnormal_ependyma_morphology2.51752819
12MP0001986_abnormal_taste_sensitivity2.48873449
13MP0008877_abnormal_DNA_methylation2.43648441
14MP0001348_abnormal_lacrimal_gland2.37201740
15MP0008995_early_reproductive_senescence2.36687486
16MP0003787_abnormal_imprinting2.33697713
17MP0001835_abnormal_antigen_presentation2.33480794
18MP0005187_abnormal_penis_morphology2.29888362
19MP0000537_abnormal_urethra_morphology2.23347207
20MP0000751_myopathy2.23248542
21MP0005423_abnormal_somatic_nervous2.21691738
22MP0005310_abnormal_salivary_gland2.19309657
23MP0003221_abnormal_cardiomyocyte_apopto2.17688270
24MP0002064_seizures2.09404227
25MP0001970_abnormal_pain_threshold2.05406624
26MP0002735_abnormal_chemical_nociception2.04508839
27MP0002102_abnormal_ear_morphology1.97284397
28MP0003880_abnormal_central_pattern1.93351586
29MP0003121_genomic_imprinting1.88093003
30MP0003122_maternal_imprinting1.86290814
31MP0003941_abnormal_skin_development1.83403370
32MP0003879_abnormal_hair_cell1.81009344
33MP0005646_abnormal_pituitary_gland1.77969275
34MP0006276_abnormal_autonomic_nervous1.77719361
35MP0002751_abnormal_autonomic_nervous1.72487612
36MP0002148_abnormal_hypersensitivity_rea1.71947627
37MP0001873_stomach_inflammation1.70666722
38MP0000685_abnormal_immune_system1.65755814
39MP0005171_absent_coat_pigmentation1.63470995
40MP0003123_paternal_imprinting1.59281003
41MP0005671_abnormal_response_to1.56865653
42MP0001790_abnormal_immune_system1.50878391
43MP0005387_immune_system_phenotype1.50878391
44MP0002163_abnormal_gland_morphology1.50482676
45MP0000955_abnormal_spinal_cord1.44726262
46MP0006082_CNS_inflammation1.38682847
47MP0002090_abnormal_vision1.38451332
48MP0001177_atelectasis1.37870082
49MP0004811_abnormal_neuron_physiology1.35723791
50MP0001486_abnormal_startle_reflex1.34908057
51MP0004782_abnormal_surfactant_physiolog1.34077180
52MP0004510_myositis1.34028898
53MP0009785_altered_susceptibility_to1.29491031
54MP0000681_abnormal_thyroid_gland1.27150404
55MP0005499_abnormal_olfactory_system1.26460446
56MP0005394_taste/olfaction_phenotype1.26460446
57MP0005647_abnormal_sex_gland1.23209821
58MP0010386_abnormal_urinary_bladder1.22975491
59MP0002938_white_spotting1.22632899
60MP0000613_abnormal_salivary_gland1.22149830
61MP0004742_abnormal_vestibular_system1.21919520
62MP0003315_abnormal_perineum_morphology1.21546937
63MP0005379_endocrine/exocrine_gland_phen1.21367462
64MP0002557_abnormal_social/conspecific_i1.19245823
65MP0002572_abnormal_emotion/affect_behav1.18516070
66* MP0002066_abnormal_motor_capabilities/c1.17612447
67MP0002638_abnormal_pupillary_reflex1.16300683
68* MP0002152_abnormal_brain_morphology1.14469470
69* MP0002882_abnormal_neuron_morphology1.14441666
70MP0001968_abnormal_touch/_nociception1.14429760
71MP0001501_abnormal_sleep_pattern1.14125250
72MP0004924_abnormal_behavior1.13925971
73MP0005386_behavior/neurological_phenoty1.13925971
74MP0002132_abnormal_respiratory_system1.13684696
75MP0002736_abnormal_nociception_after1.12423515
76MP0004133_heterotaxia1.12345062
77MP0002063_abnormal_learning/memory/cond1.11923345
78MP0005367_renal/urinary_system_phenotyp1.11670498
79MP0000516_abnormal_urinary_system1.11670498
80MP0003937_abnormal_limbs/digits/tail_de1.09643345
81MP0003183_abnormal_peptide_metabolism1.09305923
82MP0003136_yellow_coat_color1.09297072
83MP0002396_abnormal_hematopoietic_system1.09118045
84MP0003119_abnormal_digestive_system1.08936888
85MP0004859_abnormal_synaptic_plasticity1.05925856
86MP0000013_abnormal_adipose_tissue1.05814255
87MP0000778_abnormal_nervous_system1.05690192
88MP0009745_abnormal_behavioral_response1.05680550
89MP0000015_abnormal_ear_pigmentation1.04850525
90MP0005409_darkened_coat_color1.04019066
91MP0000026_abnormal_inner_ear1.02246207
92MP0000383_abnormal_hair_follicle1.01715440
93MP0008004_abnormal_stomach_pH0.99959650
94MP0008058_abnormal_DNA_repair0.99765982
95MP0001529_abnormal_vocalization0.97303265
96MP0000579_abnormal_nail_morphology0.97131298
97MP0001485_abnormal_pinna_reflex0.95994565
98MP0002095_abnormal_skin_pigmentation0.95949417
99MP0003385_abnormal_body_wall0.95771910
100MP0002734_abnormal_mechanical_nocicepti0.95019419
101MP0002184_abnormal_innervation0.94585612
102MP0005000_abnormal_immune_tolerance0.94269887
103MP0003878_abnormal_ear_physiology0.93545661
104MP0005377_hearing/vestibular/ear_phenot0.93545661
105MP0003763_abnormal_thymus_physiology0.92142876
106MP0003724_increased_susceptibility_to0.91796241
107MP0003635_abnormal_synaptic_transmissio0.91252062
108MP0004142_abnormal_muscle_tone0.90667522
109MP0001905_abnormal_dopamine_level0.89922732
110MP0002419_abnormal_innate_immunity0.89909414
111MP0001440_abnormal_grooming_behavior0.89473095
112MP0001299_abnormal_eye_distance/0.89164138
113MP0001800_abnormal_humoral_immune0.88209317
114MP0005025_abnormal_response_to0.88086207
115MP0009046_muscle_twitch0.88020588
116MP0001963_abnormal_hearing_physiology0.86788375
117MP0000678_abnormal_parathyroid_gland0.85653920
118MP0002452_abnormal_antigen_presenting0.83337240
119* MP0003861_abnormal_nervous_system0.83232977
120* MP0001502_abnormal_circadian_rhythm0.82082595
121MP0000569_abnormal_digit_pigmentation0.81576067
122MP0002233_abnormal_nose_morphology0.80364884
123MP0009703_decreased_birth_body0.80125799
124MP0001984_abnormal_olfaction0.80031477
125MP0002272_abnormal_nervous_system0.79996343
126MP0002723_abnormal_immune_serum0.79944462
127MP0003935_abnormal_craniofacial_develop0.79638936
128MP0009764_decreased_sensitivity_to0.79434199
129MP0008789_abnormal_olfactory_epithelium0.78171630
130MP0000631_abnormal_neuroendocrine_gland0.78107882
131MP0002138_abnormal_hepatobiliary_system0.77974099
132MP0002069_abnormal_eating/drinking_beha0.77850589
133MP0002067_abnormal_sensory_capabilities0.77659955
134MP0000470_abnormal_stomach_morphology0.77313315
135MP0001819_abnormal_immune_cell0.77035348
136MP0009672_abnormal_birth_weight0.74553297
137MP0005248_abnormal_Harderian_gland0.73984803
138MP0005174_abnormal_tail_pigmentation0.73192058
139MP0002420_abnormal_adaptive_immunity0.72985238
140MP0003633_abnormal_nervous_system0.72720751
141MP0003137_abnormal_impulse_conducting0.72704016
142MP0000372_irregular_coat_pigmentation0.71568605
143MP0001664_abnormal_digestion0.71546059
144MP0005075_abnormal_melanosome_morpholog0.71217210
145MP0002752_abnormal_somatic_nervous0.67197037
146MP0001919_abnormal_reproductive_system0.66752900
147MP0002733_abnormal_thermal_nociception0.66525024
148MP0003755_abnormal_palate_morphology0.65084958
149MP0005551_abnormal_eye_electrophysiolog0.64557120
150MP0002229_neurodegeneration0.63227076
151MP0003718_maternal_effect0.62970210
152MP0004085_abnormal_heartbeat0.61830408
153* MP0002081_perinatal_lethality0.60988547
154MP0003631_nervous_system_phenotype0.59646979
155MP0000049_abnormal_middle_ear0.58842027
156* MP0010770_preweaning_lethality0.58733158
157* MP0002082_postnatal_lethality0.58733158
158MP0005253_abnormal_eye_physiology0.57897270
159MP0003938_abnormal_ear_development0.56400752
160* MP0010768_mortality/aging0.55085131

Predicted human phenotypes

RankGene SetZ-score
1Pendular nystagmus (HP:0012043)8.15589818
2Hepatoblastoma (HP:0002884)5.38702137
3Chronic mucocutaneous candidiasis (HP:0002728)4.57762973
4Recurrent cutaneous fungal infections (HP:0011370)4.57762973
5Abnormality of the labia minora (HP:0012880)4.54634080
6Chromosomal breakage induced by crosslinking agents (HP:0003221)4.49295599
7Short 1st metacarpal (HP:0010034)4.22366650
8Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)4.22366650
9Chromsome breakage (HP:0040012)4.17626393
10Febrile seizures (HP:0002373)3.83569125
11Drooling (HP:0002307)3.82300977
12Abnormality of the 1st metacarpal (HP:0010009)3.71664308
13Horizontal nystagmus (HP:0000666)3.65111046
14Hyperventilation (HP:0002883)3.61903897
15Excessive salivation (HP:0003781)3.58125595
16Septate vagina (HP:0001153)3.57303356
17Broad-based gait (HP:0002136)3.49504721
18Keratoconjunctivitis (HP:0001096)3.46329329
19Shoulder girdle muscle weakness (HP:0003547)3.43817677
20Abnormal hair whorl (HP:0010721)3.40503020
21Myokymia (HP:0002411)3.34066922
22Gait imbalance (HP:0002141)3.31393194
23Papillary thyroid carcinoma (HP:0002895)3.26544885
24Prostate neoplasm (HP:0100787)3.25148237
25Pelvic girdle muscle weakness (HP:0003749)3.07876138
26Decreased lacrimation (HP:0000633)3.06574009
27Abnormality of incisor morphology (HP:0011063)3.06279553
28Ankle clonus (HP:0011448)2.96305630
29Abnormality of the musculature of the pelvis (HP:0001469)2.95204017
30Abnormality of the hip-girdle musculature (HP:0001445)2.95204017
31Mutism (HP:0002300)2.91707363
32Abnormality of calcium-phosphate metabolism (HP:0100530)2.91683830
33White forelock (HP:0002211)2.91548453
34Patchy hypopigmentation of hair (HP:0011365)2.88995035
35Neoplasm of the adrenal cortex (HP:0100641)2.85845861
36Type 2 muscle fiber atrophy (HP:0003554)2.83393425
37Spontaneous abortion (HP:0005268)2.83126636
38Progressive inability to walk (HP:0002505)2.82515812
39Congenital primary aphakia (HP:0007707)2.80370135
40Recurrent fungal infections (HP:0002841)2.80237146
41Focal motor seizures (HP:0011153)2.77371348
42Atonic seizures (HP:0010819)2.76216775
43Eczematoid dermatitis (HP:0000976)2.71734284
44Focal seizures (HP:0007359)2.69244143
45Retrobulbar optic neuritis (HP:0100654)2.67670775
46Optic neuritis (HP:0100653)2.67670775
47Abnormality of DNA repair (HP:0003254)2.66866474
48Hypsarrhythmia (HP:0002521)2.65712275
49Keratitis (HP:0000491)2.65272615
50Poor suck (HP:0002033)2.63639129
51Large earlobe (HP:0009748)2.62408654
52Nephrogenic diabetes insipidus (HP:0009806)2.61198030
53Conical tooth (HP:0000698)2.60115874
54Akinesia (HP:0002304)2.59495061
55EEG with generalized epileptiform discharges (HP:0011198)2.59395106
56Epileptiform EEG discharges (HP:0011182)2.58455586
57Vaginal atresia (HP:0000148)2.54565227
58Epidermoid cyst (HP:0200040)2.51084320
59Short phalanx of the thumb (HP:0009660)2.50187368
60Aplasia cutis congenita (HP:0001057)2.49396222
61Lip pit (HP:0100267)2.48308669
62Spastic gait (HP:0002064)2.46943242
63Cheilitis (HP:0100825)2.45817529
64Generalized tonic-clonic seizures (HP:0002069)2.41229626
65Choanal stenosis (HP:0000452)2.38986548
66Increased IgM level (HP:0003496)2.38431359
67Ureteral stenosis (HP:0000071)2.38370868
68Congenital sensorineural hearing impairment (HP:0008527)2.38038922
69Genital tract atresia (HP:0001827)2.36776011
70Recurrent skin infections (HP:0001581)2.35137936
71Urinary urgency (HP:0000012)2.35117307
72Hypothermia (HP:0002045)2.32106756
73Abnormality of the nasal septum (HP:0000419)2.31732284
74Ectropion (HP:0000656)2.27001278
75Postural instability (HP:0002172)2.26981923
76Recurrent abscess formation (HP:0002722)2.25009709
77Alveolar cell carcinoma (HP:0006519)2.24746315
78Upper limb muscle weakness (HP:0003484)2.24004188
79Abnormality of the renal collecting system (HP:0004742)2.22711080
80Absent/shortened dynein arms (HP:0200106)2.22073746
81Dynein arm defect of respiratory motile cilia (HP:0012255)2.22073746
82Aplasia/Hypoplasia of the spleen (HP:0010451)2.21296854
83Esotropia (HP:0000565)2.21122029
84Ectopic kidney (HP:0000086)2.20000626
853-Methylglutaconic aciduria (HP:0003535)2.19408390
86Muscle fiber atrophy (HP:0100295)2.18733060
87Limb-girdle muscle atrophy (HP:0003797)2.18593146
88Abnormal delayed hypersensitivity skin test (HP:0002963)2.17753189
89Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.17631840
90Polyphagia (HP:0002591)2.17345892
91Asplenia (HP:0001746)2.15043298
92Peripheral hypomyelination (HP:0007182)2.13677593
93Absent eyebrow (HP:0002223)2.12172226
94Bicornuate uterus (HP:0000813)2.12001466
95Late onset (HP:0003584)2.09928730
96Scrotal hypoplasia (HP:0000046)2.09314338
97Ureteral obstruction (HP:0006000)2.07690444
98Aplasia/Hypoplasia of the uvula (HP:0010293)2.06978520
99Cortical dysplasia (HP:0002539)2.06827019
100Abnormal tarsal ossification (HP:0008369)2.06646769
101Specific learning disability (HP:0001328)2.06303662
102Micropenis (HP:0000054)2.05742900
103Reduced antithrombin III activity (HP:0001976)2.04220504
104Failure to thrive in infancy (HP:0001531)2.04028487
105Prominent supraorbital ridges (HP:0000336)2.03721466
106Protruding tongue (HP:0010808)2.03489477
107Premature loss of primary teeth (HP:0006323)2.03206158
108Hyperphosphatemia (HP:0002905)2.03192331
109Anomalous pulmonary venous return (HP:0010772)2.02900201
110Clubbing of toes (HP:0100760)2.02710001
111Abnormality of the fovea (HP:0000493)2.02419171
112Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.02398414
113Duplicated collecting system (HP:0000081)2.02335989
114Exercise-induced myalgia (HP:0003738)2.01739356
115Fibular aplasia (HP:0002990)2.01388381
116Recurrent bacterial skin infections (HP:0005406)2.00957860
117Widely patent fontanelles and sutures (HP:0004492)2.00759024
118Abnormality of the prostate (HP:0008775)1.99443080
119Abnormality of salivation (HP:0100755)1.97415842
120Amelogenesis imperfecta (HP:0000705)1.97384582
121Epileptic encephalopathy (HP:0200134)1.97092985
122Thyroid-stimulating hormone excess (HP:0002925)1.96969049
123Aplasia/Hypoplasia of the sternum (HP:0006714)1.96951576
124Cupped ear (HP:0000378)1.96925333
125Abnormality of the preputium (HP:0100587)1.96626302
126Dry hair (HP:0011359)1.95551342
127Generalized myoclonic seizures (HP:0002123)1.94428573
128Thyroid carcinoma (HP:0002890)1.94224257
129Cerebral hypomyelination (HP:0006808)1.93618323
130Agammaglobulinemia (HP:0004432)1.92482862
131Recurrent pneumonia (HP:0006532)1.91673678
132Mediastinal lymphadenopathy (HP:0100721)1.89934927
133Myositis (HP:0100614)1.89433199
134Intestinal atresia (HP:0011100)1.89248937
135Poor coordination (HP:0002370)1.88406257
136Broad foot (HP:0001769)1.88294855
137Chronic hepatic failure (HP:0100626)1.88007045
138Aplasia/Hypoplasia of the fovea (HP:0008060)1.87634430
139Hypoplasia of the fovea (HP:0007750)1.87634430
140Osteomalacia (HP:0002749)1.85752863
141Abnormality of the pubic bones (HP:0003172)1.85516519
142Stomach cancer (HP:0012126)1.85088085
143Split foot (HP:0001839)1.84924420
144Lower limb muscle weakness (HP:0007340)1.84568778
145Flat occiput (HP:0005469)1.83088583
146True hermaphroditism (HP:0010459)1.83073819
147Abnormality of the metopic suture (HP:0005556)1.83042501
148Dialeptic seizures (HP:0011146)1.80907107
149Intellectual disability, severe (HP:0010864)1.80834373
150Neoplasm of the tracheobronchial system (HP:0100552)1.80147641
151Limb dystonia (HP:0002451)1.80053235
152Abnormality of the incisor (HP:0000676)1.78148930
153Colon cancer (HP:0003003)1.78089673
154Orchitis (HP:0100796)1.78075848
155Long clavicles (HP:0000890)1.76338312
156Cutaneous finger syndactyly (HP:0010554)1.76117031
157Alacrima (HP:0000522)1.75071429
158Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.74027459
159Decreased activity of mitochondrial respiratory chain (HP:0008972)1.74027459
160Gingivitis (HP:0000230)1.73587396
161Midline defect of the nose (HP:0004122)1.73283947
162Hip dysplasia (HP:0001385)1.72661698
163Abnormal auditory evoked potentials (HP:0006958)1.72398547
164Abnormal ciliary motility (HP:0012262)1.72266055
165Decreased central vision (HP:0007663)1.71630778
166Fair hair (HP:0002286)1.70352846
167Palpebral edema (HP:0100540)1.69249180
168Panhypogammaglobulinemia (HP:0003139)1.69237084
169Generalized hypopigmentation of hair (HP:0011358)1.68419698
170Duplication of thumb phalanx (HP:0009942)1.68259861
171Absent speech (HP:0001344)1.67528835
172Xerostomia (HP:0000217)1.67257359
173Weak cry (HP:0001612)1.65667108
174Fatigable weakness (HP:0003473)1.65308630
175Abnormality of the neuromuscular junction (HP:0003398)1.65308630
176Onycholysis (HP:0001806)1.64558243
177Cutaneous syndactyly (HP:0012725)1.64289236
178Medial flaring of the eyebrow (HP:0010747)1.64016746
179Inability to walk (HP:0002540)1.63982427
180Obstructive lung disease (HP:0006536)1.63107467
181Chronic obstructive pulmonary disease (HP:0006510)1.63107467
182Submucous cleft hard palate (HP:0000176)1.62010547
183Abnormality of the columella (HP:0009929)1.58518536
184Pancreatic fibrosis (HP:0100732)1.57547934
185Tented upper lip vermilion (HP:0010804)1.56927626
186Recurrent lower respiratory tract infections (HP:0002783)1.56924629
187Type I transferrin isoform profile (HP:0003642)1.56854901
188* Optic nerve hypoplasia (HP:0000609)1.55502456

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.33227823
2WNK34.09291927
3SIK33.86614394
4MAP3K143.20179446
5PRPF4B3.18878396
6MINK12.97932961
7MAP3K42.91070938
8MAP4K22.65900863
9YES12.54292019
10TXK2.44541315
11EPHA32.35055491
12PRKD32.21904332
13CSNK1G22.21158150
14INSRR2.17591251
15CSNK1G32.17215170
16DAPK22.16492856
17LATS22.14496019
18CSNK1A1L2.10249860
19ADRBK22.03461651
20MAPK131.95427785
21MARK11.92912808
22BMPR1B1.91499228
23ERBB31.84538575
24CSNK1G11.83755028
25SIK21.82292236
26EIF2AK21.80730274
27AKT31.78953369
28TNIK1.76630771
29MAP2K71.72558793
30IRAK41.61191956
31IRAK31.59571187
32DYRK21.52467187
33SGK21.51560910
34ZAK1.47132827
35NTRK31.47092869
36CDK81.42630821
37MKNK21.42620230
38UHMK11.39733595
39BMPR21.32246431
40MUSK1.31370488
41PRKCG1.31084840
42TRIM281.29918534
43GRK71.27044660
44CDK31.26450696
45DAPK11.21094050
46NTRK21.08567376
47RPS6KA41.08258412
48MAP2K41.06065628
49PKN11.03390832
50TAOK11.01622946
51CHUK1.00985281
52TSSK60.98545492
53STK240.97931327
54TAOK20.97732253
55IRAK10.96372251
56MKNK10.95884463
57TEC0.94911010
58STK38L0.93028493
59DYRK1A0.92789070
60CAMK2B0.91825203
61MATK0.90983695
62GRK10.90124787
63NUAK10.89566777
64IKBKB0.89496043
65EPHA20.88168000
66MAP3K120.87527803
67SGK4940.87200834
68SGK2230.87200834
69BCR0.82550639
70PRKCE0.81084454
71KIT0.79209594
72CDK190.77871703
73CAMK2G0.76662026
74NLK0.76661475
75STK160.76250848
76EPHA40.74242743
77SCYL20.73978163
78BLK0.71989418
79STK380.71399628
80CLK10.69420832
81IKBKE0.68996780
82SGK30.68494179
83GRK50.67575676
84JAK30.66251395
85MAP3K130.65393475
86RIPK40.65122820
87CDK140.64483224
88NEK60.63832649
89SYK0.62938098
90MAP2K60.62576085
91PIK3CA0.61239397
92MAP3K50.58898055
93RPS6KA20.58705093
94PLK20.58682778
95BCKDK0.58296937
96FGFR30.57713749
97MAP3K60.57224479
98LYN0.57204483
99DYRK30.56938831
100CSNK1D0.56540126
101JAK10.56496256
102PRKCZ0.55438111
103SGK10.55351078
104MARK30.55068719
105CDK180.54116640
106CDC42BPA0.53845794
107PAK60.52374240
108CDC70.51638120
109CDK150.49046195
110EGFR0.48706499
111PHKG20.48013831
112PHKG10.48013831
113VRK10.46011210
114CAMK2A0.45927123
115SRPK10.45589548
116NME10.44246249
117LATS10.42826901
118HCK0.42094068
119CCNB10.40844972
120CDK11A0.39888696
121PRKG10.39734254
122BRAF0.39437306
123MAPK100.39425854
124FGFR20.38886845
125PRKD10.38169260
126PAK30.36877267
127PRKACA0.35935311
128GSK3B0.35710944
129EPHB20.35258919
130PRKACB0.34941844
131FRK0.34621540
132CAMK10.33874981
133PRKCD0.33344338
134PIK3CG0.33282918
135OXSR10.33098968
136TNK20.32975897
137CSNK1A10.32671968
138IRAK20.32662678
139BRD40.32602790
140NTRK10.32539143
141RPS6KA30.31222787
142PINK10.29909657
143CAMKK10.29871922
144PRKDC0.29479179
145SIK10.29205053
146MAPK120.29109752
147MAPK70.28911401
148PRKAA10.28852910
149RPS6KB10.28626813
150RET0.28283067
151CDK50.28243342
152TYK20.27569393
153MAPK90.27228687
154CAMK40.26948867
155CSK0.26905404
156CSNK1E0.26555155
157PLK40.26528767
158LCK0.26278996
159PLK30.25933317
160ATM0.25758756
161MAPK150.25357553
162MAPK80.24560598
163RPS6KA50.24162120

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.65638851
2Intestinal immune network for IgA production_Homo sapiens_hsa046722.16461917
3Graft-versus-host disease_Homo sapiens_hsa053322.13086070
4Allograft rejection_Homo sapiens_hsa053301.98817735
5Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.95338069
6Primary immunodeficiency_Homo sapiens_hsa053401.94491300
7NF-kappa B signaling pathway_Homo sapiens_hsa040641.94458676
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.89939825
9Long-term potentiation_Homo sapiens_hsa047201.79298129
10Autoimmune thyroid disease_Homo sapiens_hsa053201.77800220
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.74708941
12Morphine addiction_Homo sapiens_hsa050321.71918491
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.70055064
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.64734712
15Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.58836892
16African trypanosomiasis_Homo sapiens_hsa051431.56635296
17Taste transduction_Homo sapiens_hsa047421.55364903
18Serotonergic synapse_Homo sapiens_hsa047261.51009209
19Oocyte meiosis_Homo sapiens_hsa041141.50001623
20Rheumatoid arthritis_Homo sapiens_hsa053231.46735151
21Type I diabetes mellitus_Homo sapiens_hsa049401.46415924
22Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.46182963
23Gastric acid secretion_Homo sapiens_hsa049711.45740374
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.44591798
25Toll-like receptor signaling pathway_Homo sapiens_hsa046201.41955460
26Measles_Homo sapiens_hsa051621.41769604
27SNARE interactions in vesicular transport_Homo sapiens_hsa041301.40577469
28Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.35904699
29NOD-like receptor signaling pathway_Homo sapiens_hsa046211.32639529
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.32502286
31Olfactory transduction_Homo sapiens_hsa047401.32409368
32Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.32173245
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.30363779
34RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.28593257
35Hematopoietic cell lineage_Homo sapiens_hsa046401.27119725
36Asthma_Homo sapiens_hsa053101.27015301
37Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.26427827
38Fanconi anemia pathway_Homo sapiens_hsa034601.24532281
39Leishmaniasis_Homo sapiens_hsa051401.23917307
40Axon guidance_Homo sapiens_hsa043601.16775061
41Protein export_Homo sapiens_hsa030601.16265761
42Influenza A_Homo sapiens_hsa051641.14205707
43Sphingolipid metabolism_Homo sapiens_hsa006001.12891386
44Circadian entrainment_Homo sapiens_hsa047131.11532324
45Glutamatergic synapse_Homo sapiens_hsa047241.10752803
46Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.09769499
47Jak-STAT signaling pathway_Homo sapiens_hsa046301.09393192
48Chemokine signaling pathway_Homo sapiens_hsa040621.08700591
49GABAergic synapse_Homo sapiens_hsa047271.07397816
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.07183367
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.06213212
52Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.05868689
53Gap junction_Homo sapiens_hsa045401.05043943
54Calcium signaling pathway_Homo sapiens_hsa040201.04105666
55Vibrio cholerae infection_Homo sapiens_hsa051101.03640879
56TNF signaling pathway_Homo sapiens_hsa046681.03514868
57ABC transporters_Homo sapiens_hsa020100.97054510
58Osteoclast differentiation_Homo sapiens_hsa043800.96860979
59Herpes simplex infection_Homo sapiens_hsa051680.94920143
60Tuberculosis_Homo sapiens_hsa051520.94283799
61Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.92843182
62Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.89063419
63Basal transcription factors_Homo sapiens_hsa030220.88050043
64Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.86692002
65Phagosome_Homo sapiens_hsa041450.85993903
66Melanogenesis_Homo sapiens_hsa049160.84570832
67Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.84125665
68Estrogen signaling pathway_Homo sapiens_hsa049150.83321784
69Phototransduction_Homo sapiens_hsa047440.82591285
70Malaria_Homo sapiens_hsa051440.82492329
71Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.81815261
72Prolactin signaling pathway_Homo sapiens_hsa049170.81643241
73Cocaine addiction_Homo sapiens_hsa050300.81394133
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80716203
75Vitamin B6 metabolism_Homo sapiens_hsa007500.80102388
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79511252
77Amphetamine addiction_Homo sapiens_hsa050310.79235667
78Synaptic vesicle cycle_Homo sapiens_hsa047210.79217092
79Arachidonic acid metabolism_Homo sapiens_hsa005900.79210399
80Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.78682934
81Cholinergic synapse_Homo sapiens_hsa047250.78296070
82Melanoma_Homo sapiens_hsa052180.76494228
83Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.75995096
84ErbB signaling pathway_Homo sapiens_hsa040120.74657915
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.74356301
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73937302
87Butanoate metabolism_Homo sapiens_hsa006500.73872705
88Steroid biosynthesis_Homo sapiens_hsa001000.72899079
89Salivary secretion_Homo sapiens_hsa049700.72616489
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.72321524
91Ras signaling pathway_Homo sapiens_hsa040140.69209710
92mRNA surveillance pathway_Homo sapiens_hsa030150.68277057
93Pertussis_Homo sapiens_hsa051330.67200323
94Regulation of autophagy_Homo sapiens_hsa041400.66776963
95Hepatitis B_Homo sapiens_hsa051610.65699482
96Insulin secretion_Homo sapiens_hsa049110.63499288
97GnRH signaling pathway_Homo sapiens_hsa049120.62661847
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61887382
99Salmonella infection_Homo sapiens_hsa051320.61708513
100cAMP signaling pathway_Homo sapiens_hsa040240.61425061
1012-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.61039290
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57888027
103MAPK signaling pathway_Homo sapiens_hsa040100.57462253
104Legionellosis_Homo sapiens_hsa051340.57450780
105Hedgehog signaling pathway_Homo sapiens_hsa043400.57237595
106Toxoplasmosis_Homo sapiens_hsa051450.56672191
107Ovarian steroidogenesis_Homo sapiens_hsa049130.56663779
108Alcoholism_Homo sapiens_hsa050340.55272459
109Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.54833872
110Fatty acid elongation_Homo sapiens_hsa000620.53478258
111Wnt signaling pathway_Homo sapiens_hsa043100.53380697
112cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53137426
113Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.52048230
114Antigen processing and presentation_Homo sapiens_hsa046120.51536639
115Homologous recombination_Homo sapiens_hsa034400.50743890
116Hepatitis C_Homo sapiens_hsa051600.50063769
117T cell receptor signaling pathway_Homo sapiens_hsa046600.49923021
118Ether lipid metabolism_Homo sapiens_hsa005650.48871852
119Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48098819
120Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47965034
121Shigellosis_Homo sapiens_hsa051310.47863374
122Hippo signaling pathway_Homo sapiens_hsa043900.46899396
123Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46860189
124Dopaminergic synapse_Homo sapiens_hsa047280.46753142
125Collecting duct acid secretion_Homo sapiens_hsa049660.46194529
126Type II diabetes mellitus_Homo sapiens_hsa049300.45664131
127B cell receptor signaling pathway_Homo sapiens_hsa046620.45452175
128Acute myeloid leukemia_Homo sapiens_hsa052210.44708266
129Renin secretion_Homo sapiens_hsa049240.43636468
130Long-term depression_Homo sapiens_hsa047300.43349029
131Circadian rhythm_Homo sapiens_hsa047100.43289433
132Cysteine and methionine metabolism_Homo sapiens_hsa002700.43199136
133Glioma_Homo sapiens_hsa052140.42361548
134Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42010119
135Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41686560
136Oxytocin signaling pathway_Homo sapiens_hsa049210.41503010
137Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.40160555
138Choline metabolism in cancer_Homo sapiens_hsa052310.39953529
139Apoptosis_Homo sapiens_hsa042100.39736953
140Purine metabolism_Homo sapiens_hsa002300.39668357
141Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36103837
142Basal cell carcinoma_Homo sapiens_hsa052170.35275422
143Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.35022344
144Glucagon signaling pathway_Homo sapiens_hsa049220.30707208
145Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29956663
146Fatty acid biosynthesis_Homo sapiens_hsa000610.29329645
147Peroxisome_Homo sapiens_hsa041460.29053188
148beta-Alanine metabolism_Homo sapiens_hsa004100.28160477
149Rap1 signaling pathway_Homo sapiens_hsa040150.24879536
150Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.22146592
151Spliceosome_Homo sapiens_hsa030400.21874551
152Glycerophospholipid metabolism_Homo sapiens_hsa005640.20337149
153AMPK signaling pathway_Homo sapiens_hsa041520.20143246
154RNA degradation_Homo sapiens_hsa030180.19801638

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