PROM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a pentaspan transmembrane glycoprotein. The protein localizes to membrane protrusions and is often expressed on adult stem cells, where it is thought to function in maintaining stem cell properties by suppressing differentiation. Mutations in this gene have been shown to result in retinitis pigmentosa and Stargardt disease. Expression of this gene is also associated with several types of cancer. This gene is expressed from at least five alternative promoters that are expressed in a tissue-dependent manner. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)9.88684572
2regulation of rhodopsin mediated signaling pathway (GO:0022400)9.38429780
3rhodopsin mediated signaling pathway (GO:0016056)9.17744026
4epithelial cilium movement (GO:0003351)8.89181510
5motile cilium assembly (GO:0044458)8.46819093
6axoneme assembly (GO:0035082)7.96119351
7retinal cone cell development (GO:0046549)7.20244026
8* photoreceptor cell maintenance (GO:0045494)7.17636578
9photoreceptor cell development (GO:0042461)7.07014780
10eye photoreceptor cell development (GO:0042462)6.70336199
11retinal rod cell development (GO:0046548)6.29906531
12detection of light stimulus involved in visual perception (GO:0050908)5.87594428
13detection of light stimulus involved in sensory perception (GO:0050962)5.87594428
14phototransduction, visible light (GO:0007603)5.80692538
15phototransduction (GO:0007602)5.80174406
16left/right pattern formation (GO:0060972)5.78736020
17vitamin transmembrane transport (GO:0035461)5.56790957
18detection of visible light (GO:0009584)5.54025722
19intraciliary transport (GO:0042073)5.51229888
20detection of light stimulus (GO:0009583)5.49358914
21primary alcohol catabolic process (GO:0034310)5.49059609
22regulation of cilium movement (GO:0003352)5.28704188
23GMP metabolic process (GO:0046037)5.27038946
24* eye photoreceptor cell differentiation (GO:0001754)5.25637986
25* photoreceptor cell differentiation (GO:0046530)5.25637986
26visual perception (GO:0007601)5.14926156
27sensory perception of light stimulus (GO:0050953)5.10976961
28ventricular system development (GO:0021591)5.08285146
29microtubule bundle formation (GO:0001578)4.66762465
30ethanol metabolic process (GO:0006067)4.52619646
31protein-chromophore linkage (GO:0018298)4.50447530
32positive regulation of guanylate cyclase activity (GO:0031284)4.50153072
33cilium organization (GO:0044782)4.38715506
34retina development in camera-type eye (GO:0060041)4.31398667
35cilium assembly (GO:0042384)4.25247823
36regulation of guanylate cyclase activity (GO:0031282)4.10219117
37centriole assembly (GO:0098534)3.94114734
38establishment of apical/basal cell polarity (GO:0035089)3.92638430
39detection of external stimulus (GO:0009581)3.92532609
40ethanol oxidation (GO:0006069)3.90491308
41detection of abiotic stimulus (GO:0009582)3.86960600
42peptidyl-tyrosine autophosphorylation (GO:0038083)3.84802486
43cellular response to light stimulus (GO:0071482)3.84071470
44renal filtration (GO:0097205)3.78163645
45lung epithelium development (GO:0060428)3.76689534
46intra-S DNA damage checkpoint (GO:0031573)3.75448633
47neuronal stem cell maintenance (GO:0097150)3.66694037
48seminiferous tubule development (GO:0072520)3.62095298
49definitive hemopoiesis (GO:0060216)3.56777010
50lateral ventricle development (GO:0021670)3.54410311
51diterpenoid biosynthetic process (GO:0016102)3.51488263
52hyperosmotic salinity response (GO:0042538)3.51304849
53nonmotile primary cilium assembly (GO:0035058)3.49312062
54toxin transport (GO:1901998)3.44431179
55limb bud formation (GO:0060174)3.43989746
56axon extension involved in axon guidance (GO:0048846)3.41620807
57neuron projection extension involved in neuron projection guidance (GO:1902284)3.41620807
58phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.39748020
59apical protein localization (GO:0045176)3.38358319
60negative regulation of axon guidance (GO:1902668)3.36728614
61cellular component assembly involved in morphogenesis (GO:0010927)3.34832482
62negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.29856669
63centriole replication (GO:0007099)3.28563949
64asymmetric protein localization (GO:0008105)3.26201145
65glomerular filtration (GO:0003094)3.24359757
66glandular epithelial cell differentiation (GO:0002067)3.24058361
67central nervous system myelination (GO:0022010)3.23216233
68axon ensheathment in central nervous system (GO:0032291)3.23216233
69pyrimidine-containing compound transmembrane transport (GO:0072531)3.22573418
70cell projection assembly (GO:0030031)3.16265151
71establishment or maintenance of monopolar cell polarity (GO:0061339)3.15239159
72establishment of monopolar cell polarity (GO:0061162)3.15239159
73positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.14746231
74aldehyde catabolic process (GO:0046185)3.13542566
75collecting duct development (GO:0072044)3.08949867
76negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.08813637
77fusion of sperm to egg plasma membrane (GO:0007342)3.07968202
78regulation of chromatin silencing (GO:0031935)3.07037647
79protein localization to cilium (GO:0061512)3.06335105
80calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.05454787
81embryonic foregut morphogenesis (GO:0048617)3.04680639
82intestinal epithelial cell development (GO:0060576)3.04508181
83negative regulation of T cell differentiation in thymus (GO:0033085)3.02928920
84regulation of cGMP metabolic process (GO:0030823)3.02848877
85regulation of clathrin-mediated endocytosis (GO:2000369)3.00499852
86one-carbon compound transport (GO:0019755)2.99073564
87regulation of mesenchymal cell apoptotic process (GO:2001053)2.98218306
88aggressive behavior (GO:0002118)2.97846641
89epithelial cell differentiation involved in prostate gland development (GO:0060742)2.97626477
90glutathione derivative biosynthetic process (GO:1901687)2.97594680
91glutathione derivative metabolic process (GO:1901685)2.97594680
92positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.97178366
93endocardial cushion morphogenesis (GO:0003203)2.96370899
94terpenoid biosynthetic process (GO:0016114)2.94051575
95regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.91175900
96regulation of chemokine-mediated signaling pathway (GO:0070099)2.90690074
97forebrain morphogenesis (GO:0048853)2.90612574
98sperm capacitation (GO:0048240)2.90116512
99epithelial cell fate commitment (GO:0072148)2.89087902
100microtubule depolymerization (GO:0007019)2.88564130
101positive regulation of neurological system process (GO:0031646)2.85387312
102negative regulation of axon extension involved in axon guidance (GO:0048843)2.84272430
103nucleoside diphosphate phosphorylation (GO:0006165)2.83219717
104* retina layer formation (GO:0010842)2.83030408
105lens fiber cell development (GO:0070307)2.82955251
106pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.81794272
107hair cell differentiation (GO:0035315)2.81463902
108microtubule polymerization or depolymerization (GO:0031109)2.79229679
109lateral sprouting from an epithelium (GO:0060601)2.78421854
110microtubule-based movement (GO:0007018)2.77612959
111negative regulation of transcription by competitive promoter binding (GO:0010944)2.76313637
112phospholipid translocation (GO:0045332)2.76293613
113lipid translocation (GO:0034204)2.76293613
114ear development (GO:0043583)2.75593070
115neuron fate determination (GO:0048664)2.75514910
116endocrine pancreas development (GO:0031018)2.74697988
117fatty acid elongation (GO:0030497)2.73423571
118retinoic acid metabolic process (GO:0042573)2.71434874
119protein polyglutamylation (GO:0018095)2.70889152
120O-glycan processing (GO:0016266)2.70146827
121response to xenobiotic stimulus (GO:0009410)2.69836429
122negative regulation of receptor-mediated endocytosis (GO:0048261)2.68830105
123regulation of helicase activity (GO:0051095)2.68477457
124positive regulation of cell size (GO:0045793)2.67905452
125limb development (GO:0060173)2.66365435
126appendage development (GO:0048736)2.66365435
127glomerular epithelial cell development (GO:0072310)2.64631571
128macroautophagy (GO:0016236)2.62586777
129DNA ligation (GO:0006266)2.61334374
130cellular response to hepatocyte growth factor stimulus (GO:0035729)2.59664820
131response to hepatocyte growth factor (GO:0035728)2.59664820
132negative regulation of JUN kinase activity (GO:0043508)2.59541391
133exocrine pancreas development (GO:0031017)2.59401460
134regulation of microtubule-based movement (GO:0060632)2.58341076
135hydrogen peroxide catabolic process (GO:0042744)2.57978042
136nephron tubule development (GO:0072080)2.57001507
137retinal ganglion cell axon guidance (GO:0031290)2.56511935
138dopaminergic neuron differentiation (GO:0071542)2.55848249
139kidney morphogenesis (GO:0060993)2.55470512
140Notch signaling involved in heart development (GO:0061314)2.54535951
141regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.53248315
142oligosaccharide biosynthetic process (GO:0009312)2.53183497
143positive regulation of gastrulation (GO:2000543)2.52899502
144mesenchyme morphogenesis (GO:0072132)2.52473112
145inner ear receptor cell differentiation (GO:0060113)2.52095724
146regulation of gene silencing by RNA (GO:0060966)2.51065745
147regulation of posttranscriptional gene silencing (GO:0060147)2.51065745
148regulation of gene silencing by miRNA (GO:0060964)2.51065745
149chromatin remodeling at centromere (GO:0031055)2.49851069
150lung lobe morphogenesis (GO:0060463)2.49790256
151sensory perception (GO:0007600)2.49520992
152left/right axis specification (GO:0070986)2.48528068
153negative regulation of oligodendrocyte differentiation (GO:0048715)2.48423742
154cell morphogenesis involved in neuron differentiation (GO:0048667)2.48354970
155regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.48052997
156regulation of somitogenesis (GO:0014807)2.46889747
157positive regulation of actin filament depolymerization (GO:0030836)2.46763654
158histone H2A acetylation (GO:0043968)2.46109689
159estrogen biosynthetic process (GO:0006703)2.44480689
160response to nitrosative stress (GO:0051409)2.43617909
161spermatid development (GO:0007286)2.43422605
162positive regulation of cGMP biosynthetic process (GO:0030828)2.41487252
163cellular response to radiation (GO:0071478)2.40996083
164positive regulation of smoothened signaling pathway (GO:0045880)2.40555473
165lens morphogenesis in camera-type eye (GO:0002089)2.40255660
166exogenous drug catabolic process (GO:0042738)2.40033650
167renal tubule development (GO:0061326)2.38947953
168L-ascorbic acid metabolic process (GO:0019852)2.38232628
169excretion (GO:0007588)2.38048263
170base-excision repair, AP site formation (GO:0006285)2.37796225
171lung-associated mesenchyme development (GO:0060484)2.37465341
172heart looping (GO:0001947)2.36642601
173determination of left/right symmetry (GO:0007368)2.36457148
174adhesion of symbiont to host cell (GO:0044650)2.35499225
175virion attachment to host cell (GO:0019062)2.35499225
176cilium morphogenesis (GO:0060271)2.34159029
177neuron development (GO:0048666)2.34039324
178embryonic heart tube development (GO:0035050)2.33976001
179mismatch repair (GO:0006298)2.33954838
180thrombin receptor signaling pathway (GO:0070493)2.33392774
181ribosomal small subunit assembly (GO:0000028)2.32612390
182negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.32324706
183primary alcohol metabolic process (GO:0034308)2.32126713
184phosphatidylcholine biosynthetic process (GO:0006656)2.30631494
185CENP-A containing nucleosome assembly (GO:0034080)2.29709054
186establishment of planar polarity (GO:0001736)2.29343408
187establishment of tissue polarity (GO:0007164)2.29343408
188quaternary ammonium group transport (GO:0015697)2.29109311
189formation of translation preinitiation complex (GO:0001731)2.28900961
190sperm motility (GO:0030317)2.28799770
191axonemal dynein complex assembly (GO:0070286)13.6687081
192cilium or flagellum-dependent cell motility (GO:0001539)12.1317687
193cilium movement (GO:0003341)10.3103468

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.06478263
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.99689386
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.88889636
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.80965942
5RBPJ_22232070_ChIP-Seq_NCS_Mouse3.72777390
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.98989597
7FUS_26573619_Chip-Seq_HEK293_Human2.62754890
8E2F7_22180533_ChIP-Seq_HELA_Human2.43138668
9ZNF217_24962896_ChIP-Seq_MCF-7_Human2.26956181
10EWS_26573619_Chip-Seq_HEK293_Human2.19875557
11* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.16260392
12IGF1R_20145208_ChIP-Seq_DFB_Human2.07107639
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.06715867
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.05212238
15EP300_21415370_ChIP-Seq_HL-1_Mouse2.05186410
16* CDX2_19796622_ChIP-Seq_MESCs_Mouse2.03884190
17ESR1_20079471_ChIP-ChIP_T-47D_Human1.99114691
18TRIM28_21343339_ChIP-Seq_HEK293_Human1.95825175
19GBX2_23144817_ChIP-Seq_PC3_Human1.88269210
20VDR_22108803_ChIP-Seq_LS180_Human1.84289776
21STAT6_21828071_ChIP-Seq_BEAS2B_Human1.84240805
22SOX2_27498859_Chip-Seq_STOMACH_Mouse1.83250712
23ELF1_17652178_ChIP-ChIP_JURKAT_Human1.82702977
24* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.77055134
25CBX2_27304074_Chip-Seq_ESCs_Mouse1.74159318
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.70822920
27AHR_22903824_ChIP-Seq_MCF-7_Human1.68505318
28TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.67929742
29POU5F1_16153702_ChIP-ChIP_HESCs_Human1.66620464
30MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.62620146
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.62450927
32* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.61663668
33NR3C1_21868756_ChIP-Seq_MCF10A_Human1.61462089
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60278813
35SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.59752888
36DROSHA_22980978_ChIP-Seq_HELA_Human1.57926124
37ISL1_27105846_Chip-Seq_CPCs_Mouse1.57797499
38TAF15_26573619_Chip-Seq_HEK293_Human1.55519977
39AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.54658232
40ESR1_21235772_ChIP-Seq_MCF-7_Human1.53755390
41* PIAS1_25552417_ChIP-Seq_VCAP_Human1.53096691
42FLI1_27457419_Chip-Seq_LIVER_Mouse1.51702793
43ARNT_22903824_ChIP-Seq_MCF-7_Human1.51648300
44CDX2_20551321_ChIP-Seq_CACO-2_Human1.51464481
45AR_21909140_ChIP-Seq_LNCAP_Human1.47874707
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.46109871
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.45278772
48ESR2_21235772_ChIP-Seq_MCF-7_Human1.42931404
49NANOG_16153702_ChIP-ChIP_HESCs_Human1.41098082
50EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.40709600
51ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.40327370
52* SOX2_20726797_ChIP-Seq_SW620_Human1.40265046
53SMAD3_21741376_ChIP-Seq_HESCs_Human1.40141994
54PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.38420552
55KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.38385910
56KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.38385910
57KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.38385910
58GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.38278714
59IRF1_19129219_ChIP-ChIP_H3396_Human1.36713462
60CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.36334060
61ETV1_20927104_ChIP-Seq_GIST48_Human1.33886374
62SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32119550
63* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.31939839
64FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.30579821
65TCF3_18692474_ChIP-Seq_MEFs_Mouse1.30316769
66CDX2_22108803_ChIP-Seq_LS180_Human1.30242620
67TCF4_18268006_ChIP-ChIP_LS174T_Human1.29568795
68BMI1_23680149_ChIP-Seq_NPCS_Mouse1.28636056
69FOXA1_21572438_ChIP-Seq_LNCaP_Human1.28478859
70STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.28358120
71FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.27313929
72PHF8_20622853_ChIP-Seq_HELA_Human1.27295530
73* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.27133979
74TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27058019
75NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.26720174
76SOX2_16153702_ChIP-ChIP_HESCs_Human1.25850208
77PPAR_26484153_Chip-Seq_NCI-H1993_Human1.24275111
78FOXA1_27270436_Chip-Seq_PROSTATE_Human1.23897062
79FOXA1_25329375_ChIP-Seq_VCAP_Human1.23897062
80* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.23304070
81CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22888904
82* EZH2_27294783_Chip-Seq_ESCs_Mouse1.21521138
83* FOXO3_23340844_ChIP-Seq_DLD1_Human1.20996638
84FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.20939823
85HNFA_21074721_ChIP-Seq_CACO-2_Human1.20688346
86RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.20553443
87AR_20517297_ChIP-Seq_VCAP_Human1.19799166
88FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.19512512
89EZH2_27304074_Chip-Seq_ESCs_Mouse1.18829171
90TCF4_22108803_ChIP-Seq_LS180_Human1.18352063
91RBPJ_21746931_ChIP-Seq_IB4_Human1.18137818
92RNF2_27304074_Chip-Seq_NSC_Mouse1.17661467
93* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.15822550
94SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.14538053
95NFIB_24661679_ChIP-Seq_LUNG_Mouse1.13820982
96PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.13231060
97* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.12838635
98YAP1_20516196_ChIP-Seq_MESCs_Mouse1.12732343
99EED_16625203_ChIP-ChIP_MESCs_Mouse1.12332352
100TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12040131
101E2F4_17652178_ChIP-ChIP_JURKAT_Human1.11984227
102OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11526466
103* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.11201538
104* CBP_20019798_ChIP-Seq_JUKART_Human1.10695274
105* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.10695274
106TBL1_22424771_ChIP-Seq_293T_Human1.10672834
107HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.10345171
108CJUN_26792858_Chip-Seq_BT549_Human1.10237479
109CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.09969374
110PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.09555264
111GATA4_25053715_ChIP-Seq_YYC3_Human1.09520187
112ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09466786
113CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.09167960
114NANOG_18555785_Chip-Seq_ESCs_Mouse1.08087237
115BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08039539
116FOXA1_25552417_ChIP-Seq_VCAP_Human1.07837506
117STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.07712115
118PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.07502494
119* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.07290286
120KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.07251521
121SOX2_18555785_ChIP-Seq_MESCs_Mouse1.07027372
122SMAD3_21741376_ChIP-Seq_EPCs_Human1.06283263
123* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06274200
124* RNF2_27304074_Chip-Seq_ESCs_Mouse1.05765856
125CEBPB_22108803_ChIP-Seq_LS180_Human1.04484680
126SMAD4_21741376_ChIP-Seq_HESCs_Human1.04229044
127KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03926311
128NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.03396613
129SOX9_24532713_ChIP-Seq_HFSC_Mouse1.03392680
130* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.02777265
131* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.02777265
132RING1B_27294783_Chip-Seq_NPCs_Mouse1.02699062
133WDR5_24793694_ChIP-Seq_LNCAP_Human1.02330456
134CBX2_22325352_ChIP-Seq_293T-Rex_Human1.02154807
135NFYB_21822215_ChIP-Seq_K562_Human1.01916720
136PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01865658
137SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01834295
138TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00956425
139WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00628291
140DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.00323599
141OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.00063883
142CTBP1_25329375_ChIP-Seq_LNCAP_Human0.99970998
143CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.99332442
144NFYA_21822215_ChIP-Seq_K562_Human0.99240782
145GATA1_26923725_Chip-Seq_HPCs_Mouse0.99155604
146* SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.98566408
147GATA6_25053715_ChIP-Seq_YYC3_Human0.98274013
148FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.97832658
149STAT3_23295773_ChIP-Seq_U87_Human0.97819285
150JARID2_20075857_ChIP-Seq_MESCs_Mouse0.97292395
151TCF3_18692474_ChIP-Seq_MESCs_Mouse0.97220017
152ZNF274_21170338_ChIP-Seq_K562_Hela0.96741638
153P300_19829295_ChIP-Seq_ESCs_Human0.96262031
154SOX2_19829295_ChIP-Seq_ESCs_Human0.95012674
155NANOG_19829295_ChIP-Seq_ESCs_Human0.95012674
156GATA3_24758297_ChIP-Seq_MCF-7_Human0.94579268
157GF1B_26923725_Chip-Seq_HPCs_Mouse0.94154092
158* SMAD4_21799915_ChIP-Seq_A2780_Human0.94137426
159CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94032733
160EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93696314
161AR_19668381_ChIP-Seq_PC3_Human0.92733131
162AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.92356297
163FOXA2_19822575_ChIP-Seq_HepG2_Human0.92245670
164MYC_18555785_ChIP-Seq_MESCs_Mouse0.91980946
165MYC_18940864_ChIP-ChIP_HL60_Human0.91368671
166TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.91308300
167RUNX2_22187159_ChIP-Seq_PCA_Human0.91105477

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation6.78029515
2* MP0005551_abnormal_eye_electrophysiolog6.54966168
3MP0006072_abnormal_retinal_apoptosis5.38470930
4MP0005253_abnormal_eye_physiology5.05446086
5MP0008875_abnormal_xenobiotic_pharmacok3.47028365
6* MP0005195_abnormal_posterior_eye3.19652828
7MP0000537_abnormal_urethra_morphology3.10344302
8MP0000566_synostosis2.95795619
9MP0010234_abnormal_vibrissa_follicle2.86758468
10MP0005391_vision/eye_phenotype2.86660306
11MP0000462_abnormal_digestive_system2.67831417
12* MP0001324_abnormal_eye_pigmentation2.58401242
13MP0002132_abnormal_respiratory_system2.57679377
14MP0001188_hyperpigmentation2.52427666
15MP0003950_abnormal_plasma_membrane2.52280731
16MP0009379_abnormal_foot_pigmentation2.42739306
17MP0002653_abnormal_ependyma_morphology2.27458231
18MP0003941_abnormal_skin_development2.09402374
19MP0003718_maternal_effect1.97929306
20MP0001984_abnormal_olfaction1.94181003
21MP0002396_abnormal_hematopoietic_system1.91271949
22MP0008058_abnormal_DNA_repair1.88865756
23MP0004264_abnormal_extraembryonic_tissu1.86570457
24MP0008057_abnormal_DNA_replication1.85108985
25MP0009780_abnormal_chondrocyte_physiolo1.83628300
26MP0002090_abnormal_vision1.80285034
27MP0010678_abnormal_skin_adnexa1.75701267
28* MP0002229_neurodegeneration1.75048235
29MP0003283_abnormal_digestive_organ1.72554155
30MP0005220_abnormal_exocrine_pancreas1.62205122
31MP0010030_abnormal_orbit_morphology1.60577933
32* MP0002752_abnormal_somatic_nervous1.59890078
33MP0003693_abnormal_embryo_hatching1.59106842
34MP0003943_abnormal_hepatobiliary_system1.58316301
35MP0003300_gastrointestinal_ulcer1.58120046
36MP0004885_abnormal_endolymph1.52979537
37MP0003890_abnormal_embryonic-extraembry1.48684261
38MP0009697_abnormal_copulation1.46337428
39MP0001666_abnormal_nutrient_absorption1.44375048
40MP0010094_abnormal_chromosome_stability1.41899051
41MP0004957_abnormal_blastocyst_morpholog1.40406920
42MP0002234_abnormal_pharynx_morphology1.40405926
43MP0000465_gastrointestinal_hemorrhage1.39112169
44MP0003567_abnormal_fetal_cardiomyocyte1.37667666
45MP0010386_abnormal_urinary_bladder1.35986999
46MP0002928_abnormal_bile_duct1.32867516
47MP0002254_reproductive_system_inflammat1.32101864
48MP0000678_abnormal_parathyroid_gland1.31834705
49MP0005248_abnormal_Harderian_gland1.31800935
50MP0008007_abnormal_cellular_replicative1.29539309
51MP0000383_abnormal_hair_follicle1.29375224
52MP0000681_abnormal_thyroid_gland1.28665274
53MP0004782_abnormal_surfactant_physiolog1.27962225
54MP0005085_abnormal_gallbladder_physiolo1.27120564
55MP0002638_abnormal_pupillary_reflex1.25946947
56MP0002160_abnormal_reproductive_system1.25537653
57MP0000467_abnormal_esophagus_morphology1.25005257
58MP0009703_decreased_birth_body1.23735399
59MP0005377_hearing/vestibular/ear_phenot1.21862484
60MP0003878_abnormal_ear_physiology1.21862484
61MP0002084_abnormal_developmental_patter1.20661488
62MP0003937_abnormal_limbs/digits/tail_de1.20275252
63MP0004133_heterotaxia1.16964088
64MP0004742_abnormal_vestibular_system1.14234025
65* MP0002882_abnormal_neuron_morphology1.12995051
66MP0006054_spinal_hemorrhage1.12732915
67MP0005646_abnormal_pituitary_gland1.12654345
68MP0001177_atelectasis1.12445017
69MP0010352_gastrointestinal_tract_polyps1.12270074
70MP0004272_abnormal_basement_membrane1.11577646
71MP0001293_anophthalmia1.10722161
72MP0005408_hypopigmentation1.09098115
73MP0002098_abnormal_vibrissa_morphology1.09031739
74MP0002249_abnormal_larynx_morphology1.08438394
75MP0002102_abnormal_ear_morphology1.08054257
76MP0002139_abnormal_hepatobiliary_system1.07002939
77MP0000538_abnormal_urinary_bladder1.06034917
78MP0000778_abnormal_nervous_system1.05120296
79MP0004019_abnormal_vitamin_homeostasis1.05011423
80MP0003868_abnormal_feces_composition1.04533515
81MP0001286_abnormal_eye_development1.04196175
82MP0005395_other_phenotype1.04029545
83MP0001545_abnormal_hematopoietic_system1.02191315
84MP0005397_hematopoietic_system_phenotyp1.02191315
85MP0001664_abnormal_digestion1.01794803
86MP0005423_abnormal_somatic_nervous1.01698039
87MP0005636_abnormal_mineral_homeostasis1.01665160
88MP0001346_abnormal_lacrimal_gland1.01567075
89MP0008004_abnormal_stomach_pH1.01061024
90MP0004043_abnormal_pH_regulation1.00771282
91MP0004808_abnormal_hematopoietic_stem1.00725068
92MP0005084_abnormal_gallbladder_morpholo1.00426605
93MP0005381_digestive/alimentary_phenotyp0.99969675
94MP0009384_cardiac_valve_regurgitation0.99341411
95MP0001929_abnormal_gametogenesis0.99171695
96MP0002111_abnormal_tail_morphology0.98402269
97MP0009672_abnormal_birth_weight0.97414356
98MP0003634_abnormal_glial_cell0.96529629
99MP0005623_abnormal_meninges_morphology0.95502319
100MP0002085_abnormal_embryonic_tissue0.93756058
101MP0003122_maternal_imprinting0.93750571
102MP0010368_abnormal_lymphatic_system0.93299708
103MP0003121_genomic_imprinting0.93025121
104MP0001765_abnormal_ion_homeostasis0.91630763
105MP0002092_abnormal_eye_morphology0.91123606
106MP0004270_analgesia0.90665299
107MP0005645_abnormal_hypothalamus_physiol0.90315684
108MP0003115_abnormal_respiratory_system0.90069948
109MP0009278_abnormal_bone_marrow0.89003904
110MP0002697_abnormal_eye_size0.88441758
111MP0008789_abnormal_olfactory_epithelium0.88178966
112MP0008872_abnormal_physiological_respon0.87767059
113MP0003866_abnormal_defecation0.86612800
114MP0000477_abnormal_intestine_morphology0.85437717
115MP0001502_abnormal_circadian_rhythm0.84894997
116MP0001299_abnormal_eye_distance/0.84696871
117MP0002282_abnormal_trachea_morphology0.83282075
118MP0001944_abnormal_pancreas_morphology0.82845416
119MP0003119_abnormal_digestive_system0.82502161
120MP0000762_abnormal_tongue_morphology0.82086519
121MP0000026_abnormal_inner_ear0.82031027
122MP0001849_ear_inflammation0.81928625
123MP0005410_abnormal_fertilization0.81236565
124MP0002876_abnormal_thyroid_physiology0.80175150
125MP0008932_abnormal_embryonic_tissue0.79527242
126MP0002138_abnormal_hepatobiliary_system0.79316737
127MP0000516_abnormal_urinary_system0.78138917
128MP0005367_renal/urinary_system_phenotyp0.78138917
129MP0003698_abnormal_male_reproductive0.77899075
130MP0000534_abnormal_ureter_morphology0.77049123
131MP0000490_abnormal_crypts_of0.76608704
132MP0005380_embryogenesis_phenotype0.76007807
133MP0001672_abnormal_embryogenesis/_devel0.76007807
134MP0004233_abnormal_muscle_weight0.74126432
135MP0001730_embryonic_growth_arrest0.73803935
136MP0002116_abnormal_craniofacial_bone0.72197494
137MP0000613_abnormal_salivary_gland0.72197013
138MP0005394_taste/olfaction_phenotype0.70419606
139MP0005499_abnormal_olfactory_system0.70419606
140MP0001485_abnormal_pinna_reflex0.69036467
141MP0000470_abnormal_stomach_morphology0.68971757
142MP0002009_preneoplasia0.68673298
143MP0005187_abnormal_penis_morphology0.68078681
144MP0000647_abnormal_sebaceous_gland0.67743870
145MP0005197_abnormal_uvea_morphology0.65976056
146MP0000631_abnormal_neuroendocrine_gland0.65964367
147MP0003942_abnormal_urinary_system0.65427856
148MP0002233_abnormal_nose_morphology0.65164904
149MP0003861_abnormal_nervous_system0.64868076
150MP0002751_abnormal_autonomic_nervous0.63897657
151MP0001764_abnormal_homeostasis0.63092435
152MP0003183_abnormal_peptide_metabolism0.62766501
153MP0002277_abnormal_respiratory_mucosa0.60850614
154MP0004147_increased_porphyrin_level0.59678786
155MP0003252_abnormal_bile_duct0.59546545
156MP0001879_abnormal_lymphatic_vessel0.58895538
157MP0005310_abnormal_salivary_gland0.58874358
158MP0001663_abnormal_digestive_system0.57834194
159MP0001270_distended_abdomen0.56443156
160MP0000049_abnormal_middle_ear0.56275903
161MP0003755_abnormal_palate_morphology0.56082646
162MP0006292_abnormal_olfactory_placode0.56046369

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)9.71629345
2Abnormal respiratory motile cilium morphology (HP:0005938)9.10524682
3Abnormal respiratory epithelium morphology (HP:0012253)9.10524682
4Bony spicule pigmentary retinopathy (HP:0007737)9.09822605
5Absent rod-and cone-mediated responses on ERG (HP:0007688)8.50351113
6Abnormal rod and cone electroretinograms (HP:0008323)8.48464516
7Rhinitis (HP:0012384)8.21381309
8Chorioretinal atrophy (HP:0000533)7.90862057
9Chronic bronchitis (HP:0004469)7.29486725
10Pigmentary retinal degeneration (HP:0001146)7.25537959
11Pendular nystagmus (HP:0012043)6.86638181
12* Abolished electroretinogram (ERG) (HP:0000550)6.11227976
13Bronchiectasis (HP:0002110)6.02092421
14* Central scotoma (HP:0000603)5.78571678
15* Abnormality of macular pigmentation (HP:0008002)5.57098604
16Attenuation of retinal blood vessels (HP:0007843)5.37884959
17* Scotoma (HP:0000575)5.15351465
18* Dyschromatopsia (HP:0007641)5.02490938
19* Decreased central vision (HP:0007663)4.77429344
20* Type II diabetes mellitus (HP:0005978)4.49988801
21Keratoconus (HP:0000563)4.46969243
22Increased corneal curvature (HP:0100692)4.46969243
23Severe visual impairment (HP:0001141)4.38967354
24Posterior subcapsular cataract (HP:0007787)4.37109132
25Vitreoretinal degeneration (HP:0000655)4.34132173
26Choroideremia (HP:0001139)4.34069755
27Nasal polyposis (HP:0100582)4.28170882
28* Photophobia (HP:0000613)4.17044179
29* Cone-rod dystrophy (HP:0000548)4.13418652
30* Macular degeneration (HP:0000608)4.07683080
31Bronchitis (HP:0012387)3.77783164
32Hyperactive renin-angiotensin system (HP:0000841)3.65282236
33Constricted visual fields (HP:0001133)3.55181172
34Retinitis pigmentosa (HP:0000510)3.53585964
35Chronic sinusitis (HP:0011109)3.53295224
36Tubulointerstitial nephritis (HP:0001970)3.40349399
37Congenital sensorineural hearing impairment (HP:0008527)3.38327773
38Occipital encephalocele (HP:0002085)3.35625293
39Abnormality of the nasal mucosa (HP:0000433)3.31160075
40Recurrent sinusitis (HP:0011108)3.30115368
41Infertility (HP:0000789)3.17580056
42Subcapsular cataract (HP:0000523)3.10002968
43Recurrent otitis media (HP:0000403)2.87095402
44Molar tooth sign on MRI (HP:0002419)2.80081992
45Abnormality of midbrain morphology (HP:0002418)2.80081992
46Chronic otitis media (HP:0000389)2.79814687
47Male infertility (HP:0003251)2.77182814
48Chronic hepatic failure (HP:0100626)2.67535825
49Postaxial foot polydactyly (HP:0001830)2.56216514
50Decreased electroretinogram (ERG) amplitude (HP:0000654)2.52488957
51Congenital primary aphakia (HP:0007707)2.46220078
52Gait imbalance (HP:0002141)2.37399882
53* Progressive visual loss (HP:0000529)2.36638305
54Vaginal atresia (HP:0000148)2.30142358
55True hermaphroditism (HP:0010459)2.24520876
56Cystic liver disease (HP:0006706)2.24418809
57Nephrogenic diabetes insipidus (HP:0009806)2.23304180
58Genital tract atresia (HP:0001827)2.20907840
59Medial flaring of the eyebrow (HP:0010747)2.20511459
60Retinal atrophy (HP:0001105)2.18812333
61Acute lymphatic leukemia (HP:0006721)2.17488749
62Aplasia/Hypoplasia of the spleen (HP:0010451)2.03249449
63Asplenia (HP:0001746)2.02435589
64Median cleft lip (HP:0000161)2.00905449
65Pancreatic fibrosis (HP:0100732)1.96848103
66Pancreatic cysts (HP:0001737)1.95413079
67Postaxial hand polydactyly (HP:0001162)1.94574545
68Colon cancer (HP:0003003)1.87060810
69Hyperaldosteronism (HP:0000859)1.85837044
70Renal salt wasting (HP:0000127)1.85625709
71* Wide nasal bridge (HP:0000431)1.84294436
72Poor coordination (HP:0002370)1.84082046
73Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.83127489
74Male pseudohermaphroditism (HP:0000037)1.82224210
75Decreased circulating renin level (HP:0003351)1.79625775
76Abnormality of renin-angiotensin system (HP:0000847)1.79519614
77Abnormal pancreas size (HP:0012094)1.78819012
78Polar cataract (HP:0010696)1.75992336
79Hyperkalemia (HP:0002153)1.73235924
80Oculomotor apraxia (HP:0000657)1.70174808
81Abnormality of chloride homeostasis (HP:0011422)1.69376693
82Carpal bone hypoplasia (HP:0001498)1.69317484
83Tubular atrophy (HP:0000092)1.68374458
84Esophageal atresia (HP:0002032)1.68091008
85Preaxial hand polydactyly (HP:0001177)1.66090209
86Atelectasis (HP:0100750)1.64505667
87Onycholysis (HP:0001806)1.61719719
88Bile duct proliferation (HP:0001408)1.60335748
89Abnormal biliary tract physiology (HP:0012439)1.60335748
90Acute myeloid leukemia (HP:0004808)1.60011585
91Severe Myopia (HP:0011003)1.59185189
92Hypoplastic labia majora (HP:0000059)1.58942620
93Absent frontal sinuses (HP:0002688)1.57612720
94Hyperglycinuria (HP:0003108)1.56913633
95Spontaneous abortion (HP:0005268)1.56244236
96Aplasia/Hypoplasia of the tongue (HP:0010295)1.54098958
97Reduced antithrombin III activity (HP:0001976)1.53445970
98Aplasia/Hypoplasia of the lens (HP:0008063)1.52070016
99Abnormality of the renal medulla (HP:0100957)1.51682724
100Arterial tortuosity (HP:0005116)1.50939608
101Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.50437885
102Degeneration of the lateral corticospinal tracts (HP:0002314)1.50437885
103Abnormality of the fovea (HP:0000493)1.49636858
104Facial cleft (HP:0002006)1.46672749
105Facial hemangioma (HP:0000329)1.45501306
106Bell-shaped thorax (HP:0001591)1.44452783
107Nephropathy (HP:0000112)1.43053900
108Labial hypoplasia (HP:0000066)1.42076900
109Absent hand (HP:0004050)1.41973325
110Small epiphyses (HP:0010585)1.41918936
111Hypodontia (HP:0000668)1.41698347
112Papillary thyroid carcinoma (HP:0002895)1.41486687
113Abnormal respiratory motile cilium physiology (HP:0012261)1.41419273
114Congenital hepatic fibrosis (HP:0002612)1.41156285
115Flat acetabular roof (HP:0003180)1.41132807
116Supernumerary spleens (HP:0009799)1.40467235
117Bifid tongue (HP:0010297)1.39091680
118Abnormality of the labia majora (HP:0012881)1.39072169
119Abnormality of the parathyroid morphology (HP:0011766)1.39032463
120Anencephaly (HP:0002323)1.38068789
121Abnormality of the labia minora (HP:0012880)1.37797274
122Broad foot (HP:0001769)1.36300741
123Aplasia involving bones of the extremities (HP:0009825)1.36070376
124Aplasia involving bones of the upper limbs (HP:0009823)1.36070376
125Aplasia of the phalanges of the hand (HP:0009802)1.36070376
126Recurrent bronchitis (HP:0002837)1.35986966
127Alacrima (HP:0000522)1.35977991
128Abnormality of the right ventricle (HP:0001707)1.35645902
129Tubulointerstitial abnormality (HP:0001969)1.35477630
130Anophthalmia (HP:0000528)1.35345813
131Scanning speech (HP:0002168)1.35215581
132Dynein arm defect of respiratory motile cilia (HP:0012255)1.35120070
133Absent/shortened dynein arms (HP:0200106)1.35120070
134Hyperglycinemia (HP:0002154)1.34417162
135Short ribs (HP:0000773)1.34416679
136Rhabdomyosarcoma (HP:0002859)1.33828278
137Retinal detachment (HP:0000541)1.33596505
138Thickened helices (HP:0000391)1.32849883
139Stage 5 chronic kidney disease (HP:0003774)1.31838949
140Bilateral microphthalmos (HP:0007633)1.31709775
141Aortic aneurysm (HP:0004942)1.31363433
142Clitoromegaly (HP:0000057)1.31304106
143Bifid scrotum (HP:0000048)1.31076834
144Abnormality of serine family amino acid metabolism (HP:0010894)1.30983687
145Abnormality of glycine metabolism (HP:0010895)1.30983687
146Exocrine pancreatic insufficiency (HP:0001738)1.30719517
147Esophageal varix (HP:0002040)1.30312847
148Cupped ear (HP:0000378)1.29272431
149Multicystic kidney dysplasia (HP:0000003)1.28986487
150Short thorax (HP:0010306)1.28652569
151Interstitial pulmonary disease (HP:0006530)1.28294905
152Oligodactyly (hands) (HP:0001180)1.28218889
153Nephronophthisis (HP:0000090)1.28208397
154Increased circulating renin level (HP:0000848)1.27976671
155Hypoplastic female external genitalia (HP:0012815)1.25605063
156Sensory axonal neuropathy (HP:0003390)1.25445868
157Taurodontia (HP:0000679)1.25418386
158Abnormality of permanent molar morphology (HP:0011071)1.25418386
159Abnormality of the dental root (HP:0006486)1.25418386
160Abnormal ciliary motility (HP:0012262)1.25188520
161Optic disc pallor (HP:0000543)1.25118992
162Sclerocornea (HP:0000647)1.25069297
163Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.24449295
164Narrow forehead (HP:0000341)1.24362420
165Stenosis of the external auditory canal (HP:0000402)1.23953196
166Tubulointerstitial fibrosis (HP:0005576)1.23945839
167Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.23806197
168Abnormality of renal excretion (HP:0011036)1.23787064
169Metabolic alkalosis (HP:0200114)1.23541807
170Gastrointestinal atresia (HP:0002589)1.23189297

Predicted kinase interactions (KEA)

RankGene SetZ-score
1GRK14.73200091
2STK394.39069721
3EPHA24.33448295
4FRK3.28791898
5MKNK13.17771878
6BCR3.14106858
7OXSR13.05798822
8PBK2.95647229
9MKNK22.95326158
10EPHB22.71476125
11MST42.55603279
12WNK42.38300640
13FGFR22.36110476
14LATS12.31295589
15FLT32.08276751
16VRK22.02440231
17TAF12.00929452
18AKT31.99618977
19CDK191.98226908
20INSRR1.98031717
21LMTK21.95545540
22STK241.93406358
23KIT1.92366573
24ICK1.92319205
25BRSK21.87740717
26NUAK11.79568505
27IRAK21.79075517
28MAPK151.75703483
29ACVR1B1.68591875
30NEK61.67157699
31ERBB21.56752738
32CDC71.54539624
33PLK41.50894864
34TNIK1.44376651
35TAOK31.43800243
36MELK1.41541370
37VRK11.39809959
38TIE11.38960599
39MET1.34855224
40SMG11.33919085
41MAP2K21.33398651
42MAP3K21.33094459
43TSSK61.32010719
44EPHB11.31469776
45FER1.26240196
46BMPR1B1.25946546
47PLK31.25275498
48KSR11.24612953
49NLK1.24372148
50BRD41.20719076
51SRPK11.20162794
52ZAK1.18885314
53MYLK1.15947914
54PAK31.10475474
55WEE11.08312608
56PTK21.05058346
57TYRO31.04600059
58MATK1.03988624
59NTRK11.03213700
60PLK11.02134469
61CSNK1A1L1.01940651
62MAP4K20.96178207
63PNCK0.93225365
64CDK30.92426159
65MAP3K100.89098869
66WNK10.88723463
67BCKDK0.87888352
68SGK2230.87655812
69SGK4940.87655812
70CDK60.86947971
71NEK20.86046174
72ATR0.85769658
73RPS6KA40.84141881
74TEC0.83913086
75MST1R0.83200367
76PTK60.81796959
77NME10.81284240
78NEK10.81014562
79CSF1R0.80304032
80CSNK1G30.79914241
81DYRK1B0.79766889
82ROCK10.78292744
83PAK40.76789632
84ROCK20.76409743
85DAPK10.75609319
86CSNK1G10.71678930
87MAP3K40.69991794
88FGFR10.68614809
89RPS6KB20.68005328
90ERBB40.67359610
91UHMK10.66442410
92CAMK2D0.66231483
93PDGFRB0.63995370
94ATM0.63546798
95WNK30.63224858
96PASK0.62705059
97PRKCQ0.61783769
98PIK3CA0.61227300
99PIK3CG0.60751013
100CDK90.60642859
101STK38L0.60483223
102CSNK1G20.60215727
103CAMK1G0.59784916
104DYRK30.59200320
105TGFBR10.58924183
106PDGFRA0.57521552
107HIPK20.57299275
108ADRBK10.54588504
109CHUK0.54564865
110TESK10.54515044
111CHEK20.53466879
112CDC42BPA0.53143686
113EIF2AK30.51966954
114SIK30.51511006
115STK30.50854529
116EIF2AK20.49652335
117DYRK1A0.49213263
118DMPK0.46657102
119IRAK10.46254399
120CSNK1D0.45963994
121DYRK20.45452398
122MAPKAPK50.44806299
123MAP3K70.44367420
124AURKB0.43261700
125GSK3A0.42183470
126SIK10.41784095
127PRKCE0.41103899
128PRKAA20.40842309
129PRKCZ0.40661926
130ERBB30.40510112
131PDK20.40183517
132IGF1R0.39771747
133PRKAA10.37328397
134CSNK1E0.35510509
135PRKDC0.34887061
136PRKG20.33806723
137TTK0.33058811
138PAK60.32286509
139CAMK2B0.32180642
140CDK120.31564324
141MAP2K10.30735887
142CDK80.30479170
143CHEK10.30451898
144EGFR0.30403561
145CDK20.29588222
146ALK0.29491354
147PRKCI0.29402617
148DDR20.28468726
149PKN10.27247882
150INSR0.26962724
151RPS6KC10.26918233
152RPS6KL10.26918233
153CSNK2A20.26776914
154FGFR30.26681474
155CSNK2A10.25595788
156RPS6KA60.25323811
157SGK10.24945786
158CDK70.24694246
159* SRC0.23066281
160AKT20.22748679
161MTOR0.22706365
162YES10.21198830
163SGK20.20254590

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.54146129
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.02237075
3Chemical carcinogenesis_Homo sapiens_hsa052042.83494083
4Non-homologous end-joining_Homo sapiens_hsa034502.72985850
5Histidine metabolism_Homo sapiens_hsa003402.34227167
6Caffeine metabolism_Homo sapiens_hsa002322.16566197
7Base excision repair_Homo sapiens_hsa034102.16486861
8Sulfur metabolism_Homo sapiens_hsa009202.11819469
9Phototransduction_Homo sapiens_hsa0474411.7316585
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.92946422
11Pentose and glucuronate interconversions_Homo sapiens_hsa000401.92138511
12Mismatch repair_Homo sapiens_hsa034301.89149107
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.88347239
14beta-Alanine metabolism_Homo sapiens_hsa004101.85763376
15Steroid hormone biosynthesis_Homo sapiens_hsa001401.83334765
16Propanoate metabolism_Homo sapiens_hsa006401.79788212
17Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.79494072
18Fatty acid degradation_Homo sapiens_hsa000711.73593792
19Tyrosine metabolism_Homo sapiens_hsa003501.72588884
20DNA replication_Homo sapiens_hsa030301.71347610
21Tight junction_Homo sapiens_hsa045301.70749581
22Peroxisome_Homo sapiens_hsa041461.67274504
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.65796062
24Phenylalanine metabolism_Homo sapiens_hsa003601.59917878
25Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.48255181
26Selenocompound metabolism_Homo sapiens_hsa004501.46260470
27Mineral absorption_Homo sapiens_hsa049781.44695520
28Hippo signaling pathway_Homo sapiens_hsa043901.38070235
29Ether lipid metabolism_Homo sapiens_hsa005651.33791719
30Nucleotide excision repair_Homo sapiens_hsa034201.32170017
31Basal cell carcinoma_Homo sapiens_hsa052171.32115170
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.30907790
33Axon guidance_Homo sapiens_hsa043601.30071867
34Drug metabolism - other enzymes_Homo sapiens_hsa009831.26878213
35Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.25429058
36Adherens junction_Homo sapiens_hsa045201.23088878
37Starch and sucrose metabolism_Homo sapiens_hsa005001.22370493
38Fanconi anemia pathway_Homo sapiens_hsa034601.22175607
39Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.21268866
40Notch signaling pathway_Homo sapiens_hsa043301.18478745
41Protein export_Homo sapiens_hsa030601.17629629
42Butanoate metabolism_Homo sapiens_hsa006501.15863919
43ABC transporters_Homo sapiens_hsa020101.15375190
44Cyanoamino acid metabolism_Homo sapiens_hsa004601.15257103
45Hedgehog signaling pathway_Homo sapiens_hsa043401.14402552
46Spliceosome_Homo sapiens_hsa030401.13456165
47Vibrio cholerae infection_Homo sapiens_hsa051101.13073147
48Steroid biosynthesis_Homo sapiens_hsa001001.10174434
49Pancreatic secretion_Homo sapiens_hsa049721.09201380
50Homologous recombination_Homo sapiens_hsa034401.08332126
51Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.07594324
52Linoleic acid metabolism_Homo sapiens_hsa005911.06397143
53RNA transport_Homo sapiens_hsa030131.06137909
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.06072727
55N-Glycan biosynthesis_Homo sapiens_hsa005101.02946216
56ECM-receptor interaction_Homo sapiens_hsa045121.02138750
57Sphingolipid metabolism_Homo sapiens_hsa006001.01178659
58Tryptophan metabolism_Homo sapiens_hsa003800.99987993
59Thyroid hormone synthesis_Homo sapiens_hsa049180.99058022
60Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.96566751
61mRNA surveillance pathway_Homo sapiens_hsa030150.96124089
62Fatty acid metabolism_Homo sapiens_hsa012120.95630024
63Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.94156647
64RNA degradation_Homo sapiens_hsa030180.90922899
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.90406067
66Fat digestion and absorption_Homo sapiens_hsa049750.90382583
67Purine metabolism_Homo sapiens_hsa002300.89727152
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.86854866
69Huntingtons disease_Homo sapiens_hsa050160.85941021
70Protein digestion and absorption_Homo sapiens_hsa049740.83902529
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.83530315
72Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.82709510
73Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.81777880
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.81404877
75Wnt signaling pathway_Homo sapiens_hsa043100.80643711
76* Transcriptional misregulation in cancer_Homo sapiens_hsa052020.80336932
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80131987
78Nitrogen metabolism_Homo sapiens_hsa009100.79649731
79Insulin secretion_Homo sapiens_hsa049110.78374845
80Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.77450297
81Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.75284978
82Pyruvate metabolism_Homo sapiens_hsa006200.74258825
83Basal transcription factors_Homo sapiens_hsa030220.71987752
84Arachidonic acid metabolism_Homo sapiens_hsa005900.71650585
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.71297372
86Cholinergic synapse_Homo sapiens_hsa047250.68649036
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67974642
88TGF-beta signaling pathway_Homo sapiens_hsa043500.67885763
89Metabolic pathways_Homo sapiens_hsa011000.66782670
90Pyrimidine metabolism_Homo sapiens_hsa002400.66179817
91Retinol metabolism_Homo sapiens_hsa008300.66146471
92Focal adhesion_Homo sapiens_hsa045100.66006424
93Ribosome_Homo sapiens_hsa030100.63633856
94Renal cell carcinoma_Homo sapiens_hsa052110.62743582
952-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.61422129
96Synaptic vesicle cycle_Homo sapiens_hsa047210.61221714
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61119692
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60307218
99Serotonergic synapse_Homo sapiens_hsa047260.59832569
100GABAergic synapse_Homo sapiens_hsa047270.59592273
101Proteoglycans in cancer_Homo sapiens_hsa052050.59343306
102Bladder cancer_Homo sapiens_hsa052190.58210917
103Circadian rhythm_Homo sapiens_hsa047100.57011931
104Fatty acid elongation_Homo sapiens_hsa000620.56855182
105Prostate cancer_Homo sapiens_hsa052150.56269646
106Dorso-ventral axis formation_Homo sapiens_hsa043200.56049595
107Endometrial cancer_Homo sapiens_hsa052130.54365409
108Leukocyte transendothelial migration_Homo sapiens_hsa046700.54081176
109Taste transduction_Homo sapiens_hsa047420.53690817
110Carbon metabolism_Homo sapiens_hsa012000.53218396
111Cell cycle_Homo sapiens_hsa041100.52168880
112Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.51997920
113Glutathione metabolism_Homo sapiens_hsa004800.51963030
114Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.50740898
115Bile secretion_Homo sapiens_hsa049760.49710815
116Choline metabolism in cancer_Homo sapiens_hsa052310.49626630
117Inositol phosphate metabolism_Homo sapiens_hsa005620.49589491
118Glycerolipid metabolism_Homo sapiens_hsa005610.49415668
119Small cell lung cancer_Homo sapiens_hsa052220.49341714
120PI3K-Akt signaling pathway_Homo sapiens_hsa041510.48076189
121Melanogenesis_Homo sapiens_hsa049160.47783848
122Olfactory transduction_Homo sapiens_hsa047400.46996602
123MicroRNAs in cancer_Homo sapiens_hsa052060.46428084
124Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45761997
125Glutamatergic synapse_Homo sapiens_hsa047240.45608137
126Biosynthesis of amino acids_Homo sapiens_hsa012300.45311394
127Dopaminergic synapse_Homo sapiens_hsa047280.44828658
128Ras signaling pathway_Homo sapiens_hsa040140.44508015
129Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.44255770
130Glycerophospholipid metabolism_Homo sapiens_hsa005640.43056420
131Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43051774
132Vitamin digestion and absorption_Homo sapiens_hsa049770.42988638
133Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42783930
134Vascular smooth muscle contraction_Homo sapiens_hsa042700.41883653
135Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40695015
136Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.40092506
137Fructose and mannose metabolism_Homo sapiens_hsa000510.39413466
138Pathways in cancer_Homo sapiens_hsa052000.38016991
139Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.37677960
140Gastric acid secretion_Homo sapiens_hsa049710.37123526
141cGMP-PKG signaling pathway_Homo sapiens_hsa040220.36711044
142Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35771692
143Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35330624
144Salivary secretion_Homo sapiens_hsa049700.35147226
145Lysine degradation_Homo sapiens_hsa003100.34724269
146Pentose phosphate pathway_Homo sapiens_hsa000300.33930970
147Endocytosis_Homo sapiens_hsa041440.33141836
148RNA polymerase_Homo sapiens_hsa030200.29791588
149ErbB signaling pathway_Homo sapiens_hsa040120.29149743
150Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.28777708
151Cocaine addiction_Homo sapiens_hsa050300.28023063
152Arginine and proline metabolism_Homo sapiens_hsa003300.25851847
153Other glycan degradation_Homo sapiens_hsa005110.25388266
154Circadian entrainment_Homo sapiens_hsa047130.24768388
155AMPK signaling pathway_Homo sapiens_hsa041520.24633337
156Ovarian steroidogenesis_Homo sapiens_hsa049130.24475810
157cAMP signaling pathway_Homo sapiens_hsa040240.23685961
158Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.23493981
159Phospholipase D signaling pathway_Homo sapiens_hsa040720.22047624
160Hepatitis C_Homo sapiens_hsa051600.21694791
161Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.21535081
162Pancreatic cancer_Homo sapiens_hsa052120.21241121
163Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.21055414

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