PROM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the prominin family of pentaspan membrane glycoproteins. The encoded protein localizes to basal epithelial cells and may be involved in the organization of plasma membrane microdomains. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)9.44454883
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)9.44454883
3antigen processing and presentation via MHC class Ib (GO:0002475)8.81885645
4regulation of antigen processing and presentation of peptide antigen (GO:0002583)8.64938199
5antigen processing and presentation of endogenous antigen (GO:0019883)8.04359273
6establishment of skin barrier (GO:0061436)7.03644053
7regulation of water loss via skin (GO:0033561)6.89001660
8keratinization (GO:0031424)6.26817520
9hemidesmosome assembly (GO:0031581)6.15178977
10hair cycle (GO:0042633)5.46110560
11molting cycle (GO:0042303)5.46110560
12bundle of His cell to Purkinje myocyte communication (GO:0086069)5.25008685
13multicellular organismal water homeostasis (GO:0050891)5.09729875
14thyroid hormone generation (GO:0006590)5.09430558
15regulation of acrosome reaction (GO:0060046)5.01959468
16polarized epithelial cell differentiation (GO:0030859)4.74232677
17keratinocyte differentiation (GO:0030216)4.73017706
18gap junction assembly (GO:0016264)4.58401578
19keratinocyte proliferation (GO:0043616)4.54428235
20epithelial cell maturation (GO:0002070)4.51509466
21positive regulation of antigen processing and presentation (GO:0002579)4.45655882
22establishment of planar polarity (GO:0001736)4.37825694
23establishment of tissue polarity (GO:0007164)4.37825694
24water homeostasis (GO:0030104)4.37652561
25sphingosine metabolic process (GO:0006670)4.35722856
26sphingoid metabolic process (GO:0046519)4.29123637
27positive regulation of epidermal cell differentiation (GO:0045606)4.20540579
28ear development (GO:0043583)4.13950171
29positive regulation of keratinocyte differentiation (GO:0045618)4.11838562
30thyroid hormone metabolic process (GO:0042403)4.07568616
31regulation of keratinocyte proliferation (GO:0010837)4.03206155
32cardiac right ventricle morphogenesis (GO:0003215)3.89305737
33diol metabolic process (GO:0034311)3.88853613
34epidermal cell differentiation (GO:0009913)3.86892005
35peptide cross-linking (GO:0018149)3.80215487
36regulation of keratinocyte differentiation (GO:0045616)3.77646039
37transcytosis (GO:0045056)3.75332590
38intestinal epithelial cell development (GO:0060576)3.68090035
39epidermis development (GO:0008544)3.65246534
40ectoderm development (GO:0007398)3.64220349
41interferon-gamma secretion (GO:0072643)3.61261590
42face development (GO:0060324)3.54689035
43regulation of hippo signaling (GO:0035330)3.53237351
44fusion of sperm to egg plasma membrane (GO:0007342)3.51759584
45intermediate filament organization (GO:0045109)3.51143794
46regulation of antigen processing and presentation (GO:0002577)3.49305460
47valine metabolic process (GO:0006573)3.48239345
48regulation of phospholipase A2 activity (GO:0032429)3.47999581
49sulfur amino acid catabolic process (GO:0000098)3.42455208
50positive regulation of epidermis development (GO:0045684)3.29480768
51apical protein localization (GO:0045176)3.25297552
52regulation of cell proliferation involved in kidney development (GO:1901722)3.24476613
53COPI coating of Golgi vesicle (GO:0048205)3.23925808
54Golgi transport vesicle coating (GO:0048200)3.23925808
55establishment of apical/basal cell polarity (GO:0035089)3.22454650
56regulation of endothelial cell chemotaxis (GO:2001026)3.21146516
57maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.18951592
58asymmetric protein localization (GO:0008105)3.15484507
59glandular epithelial cell differentiation (GO:0002067)3.14837089
60one-carbon compound transport (GO:0019755)3.14208205
61lateral sprouting from an epithelium (GO:0060601)3.13727881
62keratinocyte development (GO:0003334)3.12301070
63negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.12207634
64negative regulation of kidney development (GO:0090185)3.09257417
65diterpenoid biosynthetic process (GO:0016102)3.07596891
66branching involved in mammary gland duct morphogenesis (GO:0060444)3.01772268
67protein retention in ER lumen (GO:0006621)3.01228579
68ventricular cardiac muscle cell action potential (GO:0086005)3.00412288
69semaphorin-plexin signaling pathway (GO:0071526)2.99668847
70skin morphogenesis (GO:0043589)2.99535324
71columnar/cuboidal epithelial cell development (GO:0002066)2.99126369
72lung lobe morphogenesis (GO:0060463)2.98256645
73morphogenesis of embryonic epithelium (GO:0016331)2.96674839
74tight junction assembly (GO:0070830)2.96429896
75biotin metabolic process (GO:0006768)2.92579728
76epithelial cell differentiation involved in prostate gland development (GO:0060742)2.92056657
77planar cell polarity pathway involved in neural tube closure (GO:0090179)2.90717845
78endothelial cell chemotaxis (GO:0035767)2.89234782
79regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.87976484
80cornea development in camera-type eye (GO:0061303)2.86325279
81regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.85866694
82surfactant homeostasis (GO:0043129)2.85309994
83activation of Rac GTPase activity (GO:0032863)2.84202847
84response to food (GO:0032094)2.82289562
85cell-cell junction assembly (GO:0007043)2.81635296
86negative regulation of cell fate commitment (GO:0010454)2.78759809
87regulation of heart rate by cardiac conduction (GO:0086091)2.78600158
88norepinephrine metabolic process (GO:0042415)2.76885542
89lung epithelium development (GO:0060428)2.75163389
90establishment or maintenance of monopolar cell polarity (GO:0061339)2.74884722
91establishment of monopolar cell polarity (GO:0061162)2.74884722
92regulation of fatty acid beta-oxidation (GO:0031998)2.74665456
93iron ion import (GO:0097286)2.74350162
94chemical homeostasis within a tissue (GO:0048875)2.73381036
95cysteine metabolic process (GO:0006534)2.70458851
96peptide catabolic process (GO:0043171)2.70458051
97regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.69455825
98phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.68880905
99dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.68086972
100regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.68075782
101regulation of ruffle assembly (GO:1900027)2.67795845
102regulation of epidermal cell differentiation (GO:0045604)2.67649491
103regulation of epidermis development (GO:0045682)2.66745323
104negative regulation of cell fate specification (GO:0009996)2.65227231
105phosphatidylinositol acyl-chain remodeling (GO:0036149)2.65179100
106cell differentiation involved in embryonic placenta development (GO:0060706)2.64090346
107phosphatidylserine acyl-chain remodeling (GO:0036150)2.63122546
108endosome organization (GO:0007032)2.62274597
109icosanoid secretion (GO:0032309)2.61527447
110arachidonic acid secretion (GO:0050482)2.61527447
111regulation of protein localization to cell surface (GO:2000008)2.60323928
112positive regulation of histone deacetylation (GO:0031065)2.60310485
113icosanoid transport (GO:0071715)2.60289840
114fatty acid derivative transport (GO:1901571)2.60289840
115hypotonic response (GO:0006971)2.60213432
116peptidyl-tyrosine autophosphorylation (GO:0038083)2.59310431
117oocyte development (GO:0048599)2.58175163
118prostate gland epithelium morphogenesis (GO:0060740)2.58055042
119positive regulation of fatty acid beta-oxidation (GO:0032000)2.55995013
120DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.53488002
121phosphatidylcholine acyl-chain remodeling (GO:0036151)2.53279235
122hair follicle development (GO:0001942)2.53221955
123negative regulation of endopeptidase activity (GO:0010951)2.53144445
124positive regulation of Cdc42 GTPase activity (GO:0043089)2.53105961
125ethanol metabolic process (GO:0006067)2.52405582
126beta-amyloid metabolic process (GO:0050435)2.49541146
127plasma membrane fusion (GO:0045026)2.49068508
128positive regulation of glomerulus development (GO:0090193)2.46609428
129cytoskeletal anchoring at plasma membrane (GO:0007016)2.46003993
130negative regulation of peptidase activity (GO:0010466)2.45497744
131negative regulation of keratinocyte proliferation (GO:0010839)2.45432934
132G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.43094471
133collecting duct development (GO:0072044)2.41828478
134epithelial cell-cell adhesion (GO:0090136)2.40720575
135linoleic acid metabolic process (GO:0043651)2.39757959
136atrioventricular valve morphogenesis (GO:0003181)2.38348625
137intermediate filament cytoskeleton organization (GO:0045104)2.37499955
138cyclooxygenase pathway (GO:0019371)2.36252787
139primary alcohol catabolic process (GO:0034310)2.33718078
140calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.33309780
141phosphatidylserine metabolic process (GO:0006658)2.33118632
142regulation of apoptotic process involved in morphogenesis (GO:1902337)2.32983192
143mammary gland epithelial cell differentiation (GO:0060644)2.32687952
144cell-substrate junction assembly (GO:0007044)2.31570042
145gland morphogenesis (GO:0022612)2.30584242
146pattern specification involved in kidney development (GO:0061004)2.30284351
147mannose metabolic process (GO:0006013)2.30268271
148exocrine pancreas development (GO:0031017)2.28887577
149intermediate filament-based process (GO:0045103)2.27010963
150thyroid gland development (GO:0030878)2.25851365
151negative regulation of lipase activity (GO:0060192)2.25168953
152virion attachment to host cell (GO:0019062)2.25047288
153adhesion of symbiont to host cell (GO:0044650)2.25047288
154cellular response to antibiotic (GO:0071236)2.24918040
155complement activation, alternative pathway (GO:0006957)2.24680022
156retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.23271121
157prostanoid biosynthetic process (GO:0046457)2.22168335
158prostaglandin biosynthetic process (GO:0001516)2.22168335
159phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.21063839
160viral transcription (GO:0019083)2.21009551
161mesonephros development (GO:0001823)2.20826901
162endocrine hormone secretion (GO:0060986)2.19818400
163anterior/posterior axis specification, embryo (GO:0008595)2.19742824
164hormone catabolic process (GO:0042447)2.18861246
165desmosome organization (GO:0002934)10.5433619

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human4.63885421
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.51774574
3ESR1_21235772_ChIP-Seq_MCF-7_Human3.23257251
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.08402595
5ESR2_21235772_ChIP-Seq_MCF-7_Human2.97006143
6ZNF263_19887448_ChIP-Seq_K562_Human2.95330803
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.54853918
8SOX9_24532713_ChIP-Seq_HFSC_Mouse2.35447697
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.33779429
10* P63_26484246_Chip-Seq_KERATINOCYTES_Human2.33418342
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.24148385
12HIF1A_21447827_ChIP-Seq_MCF-7_Human2.19975787
13ZNF217_24962896_ChIP-Seq_MCF-7_Human2.01262225
14TP63_17297297_ChIP-ChIP_HaCaT_Human10.6223492
15SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.98199315
16FOXO3_23340844_ChIP-Seq_DLD1_Human1.96469333
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.87105816
18* SOX2_20726797_ChIP-Seq_SW620_Human1.81577954
19* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.73913878
20ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.70320952
21SOX2_27498859_Chip-Seq_STOMACH_Mouse1.68191614
22RUNX1_27514584_Chip-Seq_MCF-7_Human1.66286784
23CLOCK_20551151_ChIP-Seq_293T_Human1.59227211
24SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.57615702
25SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.57615702
26AR_21572438_ChIP-Seq_LNCaP_Human1.57558123
27GATA4_25053715_ChIP-Seq_YYC3_Human1.55821335
28ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.53773596
29ESR1_15608294_ChIP-ChIP_MCF-7_Human1.51127024
30ELF5_23300383_ChIP-Seq_T47D_Human1.47581052
31* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.47338136
32RACK7_27058665_Chip-Seq_MCF-7_Human1.46307011
33AHR_22903824_ChIP-Seq_MCF-7_Human1.45480830
34ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.37290718
35RARG_19884340_ChIP-ChIP_MEFs_Mouse1.37056320
36PPARA_22158963_ChIP-Seq_LIVER_Mouse1.36775660
37GATA3_24758297_ChIP-Seq_MCF-7_Human1.36631455
38GATA6_25053715_ChIP-Seq_YYC3_Human1.34491876
39CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.29965774
40LXR_22158963_ChIP-Seq_LIVER_Mouse1.29616245
41KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.28934755
42ESR1_20079471_ChIP-ChIP_T-47D_Human1.28414762
43PPAR_26484153_Chip-Seq_NCI-H1993_Human1.26837837
44* TP63_23658742_ChIP-Seq_EP156T_Human1.26461710
45AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.26376603
46PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.25780158
47KLF5_25053715_ChIP-Seq_YYC3_Human1.24693038
48RXR_22158963_ChIP-Seq_LIVER_Mouse1.24482878
49ARNT_22903824_ChIP-Seq_MCF-7_Human1.23114028
50SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.21780931
51ATF3_27146783_Chip-Seq_COLON_Human1.20784747
52FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.19837004
53ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.18858361
54CDX2_20551321_ChIP-Seq_CACO-2_Human1.18779268
55CJUN_26792858_Chip-Seq_BT549_Human1.17695240
56FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.17446755
57SMC4_20622854_ChIP-Seq_HELA_Human1.16320339
58* BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.15601987
59CDX2_19796622_ChIP-Seq_MESCs_Mouse1.14747916
60FOXA1_25552417_ChIP-Seq_VCAP_Human1.12184037
61ERG_21242973_ChIP-ChIP_JURKAT_Human1.11545187
62KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11008680
63* LXR_22292898_ChIP-Seq_THP-1_Human1.10527773
64ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07675197
65* TP63_22573176_ChIP-Seq_HFKS_Human1.06257016
66CTCF_27219007_Chip-Seq_Bcells_Human1.05612582
67TCF4_18268006_ChIP-ChIP_LS174T_Human1.03331977
68CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99478131
69TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96467748
70CEBPB_22108803_ChIP-Seq_LS180_Human0.96076116
71UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.95535628
72NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.94826899
73FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.94041699
74DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94025563
75TBX20_22080862_ChIP-Seq_HEART_Mouse0.92409723
76TBX20_22328084_ChIP-Seq_HEART_Mouse0.92409723
77NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.90968255
78TP53_18474530_ChIP-ChIP_U2OS_Human0.87240622
79HOXB7_26014856_ChIP-Seq_BT474_Human0.87172177
80UBF1/2_26484160_Chip-Seq_HMECs_Human0.85453826
81FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.85132004
82TET1_21490601_ChIP-Seq_MESCs_Mouse0.84470315
83RXR_22108803_ChIP-Seq_LS180_Human0.84089137
84FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.83844331
85SMAD3_21741376_ChIP-Seq_HESCs_Human0.81533145
86KDM2B_26808549_Chip-Seq_K562_Human0.79375504
87FOXM1_26456572_ChIP-Seq_MCF-7_Human0.79161198
88EP300_21415370_ChIP-Seq_HL-1_Mouse0.78714450
89BCAT_22108803_ChIP-Seq_LS180_Human0.78088131
90PIAS1_25552417_ChIP-Seq_VCAP_Human0.76974332
91E2F1_20622854_ChIP-Seq_HELA_Human0.76663837
92TP53_20018659_ChIP-ChIP_R1E_Mouse0.76066374
93RARB_24833708_ChIP-Seq_LIVER_Mouse0.74655923
94ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.74647580
95EGR1_19032775_ChIP-ChIP_M12_Human0.74544020
96P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.74239067
97KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.73999805
98KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.73999805
99KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.73999805
100SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.73711746
101* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.73081617
102PKCTHETA_26484144_Chip-Seq_BREAST_Human0.72922010
103BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.72629068
104VDR_22108803_ChIP-Seq_LS180_Human0.72495155
105CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.71353410
106SUZ12_27294783_Chip-Seq_ESCs_Mouse0.70251572
107FOXA2_19822575_ChIP-Seq_HepG2_Human0.70143976
108* CHD1_26751641_Chip-Seq_LNCaP_Human0.69748830
109TDRD3_21172665_ChIP-Seq_MCF-7_Human0.69747710
110FLI1_21867929_ChIP-Seq_CD8_Mouse0.69448026
111BCOR_27268052_Chip-Seq_Bcells_Human0.68856828
112EZH2_27294783_Chip-Seq_ESCs_Mouse0.68629732
113P68_20966046_ChIP-Seq_HELA_Human0.68128780
114CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.67810894
115FOXH1_21741376_ChIP-Seq_ESCs_Human0.67801080
116CREB1_26743006_Chip-Seq_LNCaP_Human0.67765989
117RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.67564293
118FOXA1_25329375_ChIP-Seq_VCAP_Human0.67428548
119FOXA1_27270436_Chip-Seq_PROSTATE_Human0.67428548
120GATA2_21666600_ChIP-Seq_HMVEC_Human0.67384727
121CSB_26484114_Chip-Seq_FIBROBLAST_Human0.67378741
122KDM5A_27292631_Chip-Seq_BREAST_Human0.67297902
123SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.67077019
124DROSHA_22980978_ChIP-Seq_HELA_Human0.66985608
125* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.66813898
126P53_21459846_ChIP-Seq_SAOS-2_Human0.65802480
127TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.65007550
128ELK3_25401928_ChIP-Seq_HUVEC_Human0.64610431
129TP53_22127205_ChIP-Seq_IMR90_Human0.64445740
130SA1_27219007_Chip-Seq_ERYTHROID_Human0.64325361
131RAD21_21589869_ChIP-Seq_MESCs_Mouse0.63733583
132P300_27058665_Chip-Seq_ZR-75-30cells_Human0.63161144
133EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.63111113
134ERA_21632823_ChIP-Seq_H3396_Human0.62122626

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier6.33062278
2MP0010234_abnormal_vibrissa_follicle5.80397520
3MP0005275_abnormal_skin_tensile4.82878674
4MP0002254_reproductive_system_inflammat4.09426152
5MP0005501_abnormal_skin_physiology3.66108244
6MP0000383_abnormal_hair_follicle3.63686548
7MP0010678_abnormal_skin_adnexa3.63014397
8MP0003941_abnormal_skin_development3.34295206
9MP0002098_abnormal_vibrissa_morphology3.01316066
10MP0002060_abnormal_skin_morphology2.99677016
11MP0000579_abnormal_nail_morphology2.96658132
12MP0001216_abnormal_epidermal_layer2.85198983
13MP0003705_abnormal_hypodermis_morpholog2.68492191
14MP0010771_integument_phenotype2.50919071
15MP0002009_preneoplasia2.48143750
16MP0003453_abnormal_keratinocyte_physiol2.34044698
17MP0004947_skin_inflammation2.30235810
18MP0004381_abnormal_hair_follicle2.25919556
19MP0000647_abnormal_sebaceous_gland2.17342976
20MP0000377_abnormal_hair_follicle2.16493975
21MP0001346_abnormal_lacrimal_gland2.15841247
22MP0000566_synostosis2.05318011
23MP0004185_abnormal_adipocyte_glucose1.93718690
24MP0000467_abnormal_esophagus_morphology1.93442746
25MP0000537_abnormal_urethra_morphology1.92943104
26MP0004264_abnormal_extraembryonic_tissu1.86350413
27MP0010386_abnormal_urinary_bladder1.80167753
28MP0003566_abnormal_cell_adhesion1.76718977
29MP0001666_abnormal_nutrient_absorption1.73093067
30MP0000427_abnormal_hair_cycle1.63558253
31MP0005083_abnormal_biliary_tract1.54948721
32MP0000762_abnormal_tongue_morphology1.54905098
33MP0002166_altered_tumor_susceptibility1.43966135
34MP0005367_renal/urinary_system_phenotyp1.37907627
35MP0000516_abnormal_urinary_system1.37907627
36MP0009931_abnormal_skin_appearance1.32648842
37MP0004019_abnormal_vitamin_homeostasis1.29402451
38MP0000367_abnormal_coat/_hair1.27369271
39MP0001191_abnormal_skin_condition1.25444045
40MP0002234_abnormal_pharynx_morphology1.22089128
41MP0010030_abnormal_orbit_morphology1.19749601
42MP0002006_tumorigenesis1.16304902
43MP0003011_delayed_dark_adaptation1.15498563
44MP0009384_cardiac_valve_regurgitation1.15333087
45MP0001765_abnormal_ion_homeostasis1.14846519
46MP0005451_abnormal_body_composition1.12087846
47MP0001756_abnormal_urination1.11908780
48MP0010352_gastrointestinal_tract_polyps1.09777836
49MP0000681_abnormal_thyroid_gland1.07825918
50MP0000538_abnormal_urinary_bladder1.07295351
51MP0005058_abnormal_lysosome_morphology1.07055960
52MP0008875_abnormal_xenobiotic_pharmacok1.06323349
53MP0005220_abnormal_exocrine_pancreas1.04956377
54MP0003315_abnormal_perineum_morphology1.04280390
55MP0005666_abnormal_adipose_tissue1.04199959
56MP0005409_darkened_coat_color1.01172711
57MP0002282_abnormal_trachea_morphology1.00426990
58MP0003878_abnormal_ear_physiology1.00188190
59MP0005377_hearing/vestibular/ear_phenot1.00188190
60MP0004858_abnormal_nervous_system0.98984643
61MP0008004_abnormal_stomach_pH0.98047428
62MP0000627_abnormal_mammary_gland0.97427647
63MP0002909_abnormal_adrenal_gland0.97371077
64MP0009780_abnormal_chondrocyte_physiolo0.95927580
65MP0002653_abnormal_ependyma_morphology0.95918789
66MP0002249_abnormal_larynx_morphology0.95786841
67MP0005375_adipose_tissue_phenotype0.95300928
68MP0001873_stomach_inflammation0.91115142
69MP0003300_gastrointestinal_ulcer0.89597677
70MP0000462_abnormal_digestive_system0.89030367
71MP0009643_abnormal_urine_homeostasis0.88637746
72MP0005075_abnormal_melanosome_morpholog0.87703811
73MP0000613_abnormal_salivary_gland0.86689052
74MP0001243_abnormal_dermal_layer0.86115875
75MP0003191_abnormal_cellular_cholesterol0.85795327
76MP0009053_abnormal_anal_canal0.82213074
77MP0004272_abnormal_basement_membrane0.81590534
78MP0008438_abnormal_cutaneous_collagen0.80958795
79MP0004885_abnormal_endolymph0.78449187
80MP0001851_eye_inflammation0.78136349
81MP0008789_abnormal_olfactory_epithelium0.77785686
82MP0002896_abnormal_bone_mineralization0.73899980
83MP0005310_abnormal_salivary_gland0.72961131
84MP0003638_abnormal_response/metabolism_0.72394250
85MP0003195_calcinosis0.72121075
86MP0005647_abnormal_sex_gland0.71817098
87MP0004043_abnormal_pH_regulation0.70926344
88MP0001881_abnormal_mammary_gland0.68037221
89MP0005023_abnormal_wound_healing0.67915302
90MP0002876_abnormal_thyroid_physiology0.67908470
91MP0000003_abnormal_adipose_tissue0.67787938
92MP0005636_abnormal_mineral_homeostasis0.67383974
93MP0000534_abnormal_ureter_morphology0.67223525
94MP0001340_abnormal_eyelid_morphology0.66329206
95MP0003755_abnormal_palate_morphology0.65797033
96MP0005365_abnormal_bile_salt0.65655947
97MP0001849_ear_inflammation0.65290806
98MP0009379_abnormal_foot_pigmentation0.64703079
99MP0002136_abnormal_kidney_physiology0.63930432
100MP0001188_hyperpigmentation0.63567574
101MP0002111_abnormal_tail_morphology0.62259114
102MP0002168_other_aberrant_phenotype0.58779405
103MP0003183_abnormal_peptide_metabolism0.56498854
104MP0005408_hypopigmentation0.55328231
105MP0005076_abnormal_cell_differentiation0.55209294
106MP0008872_abnormal_physiological_respon0.54713591
107MP0000470_abnormal_stomach_morphology0.54243270
108MP0002736_abnormal_nociception_after0.53848011
109MP0005646_abnormal_pituitary_gland0.53228359
110MP0003045_fibrosis0.52088905
111MP0008961_abnormal_basal_metabolism0.51943239
112MP0005670_abnormal_white_adipose0.50757464
113MP0001502_abnormal_circadian_rhythm0.49031566
114MP0003936_abnormal_reproductive_system0.47115077
115MP0005248_abnormal_Harderian_gland0.46966528
116MP0000750_abnormal_muscle_regeneration0.45906906
117MP0001919_abnormal_reproductive_system0.45275318
118MP0004782_abnormal_surfactant_physiolog0.44722457
119MP0000678_abnormal_parathyroid_gland0.43819418
120MP0001664_abnormal_digestion0.43803856
121MP0005499_abnormal_olfactory_system0.43307271
122MP0005394_taste/olfaction_phenotype0.43307271
123MP0000858_altered_metastatic_potential0.43279524
124MP0005187_abnormal_penis_morphology0.42748871
125MP0009250_abnormal_appendicular_skeleto0.42006040
126MP0004130_abnormal_muscle_cell0.41881494

Predicted human phenotypes

RankGene SetZ-score
1Hypotrichosis (HP:0001006)5.82721289
2Right ventricular cardiomyopathy (HP:0011663)5.74787056
3Pili torti (HP:0003777)5.68658380
4Onycholysis (HP:0001806)5.56080973
5Woolly hair (HP:0002224)4.94827855
6Plantar hyperkeratosis (HP:0007556)4.81640292
7Lip pit (HP:0100267)4.62161522
8Milia (HP:0001056)4.29119648
9Fragile nails (HP:0001808)4.25830700
10Increased IgE level (HP:0003212)4.21930365
11Palmoplantar hyperkeratosis (HP:0000972)4.21690579
12Abnormality of the axillary hair (HP:0100134)4.16883279
13Abnormality of secondary sexual hair (HP:0009888)4.16883279
14Amelogenesis imperfecta (HP:0000705)4.01592972
15Congenital ichthyosiform erythroderma (HP:0007431)3.89489912
16Palmar hyperkeratosis (HP:0010765)3.88797386
17Abnormality of nail color (HP:0100643)3.80416141
18Abnormal hair laboratory examination (HP:0003328)3.67891394
19Parakeratosis (HP:0001036)3.63327398
20Vacuolated lymphocytes (HP:0001922)3.33207068
21Septate vagina (HP:0001153)3.29524505
22Aplasia of the phalanges of the hand (HP:0009802)3.28123532
23Aplasia involving bones of the extremities (HP:0009825)3.28123532
24Aplasia involving bones of the upper limbs (HP:0009823)3.28123532
25Hyperphosphatemia (HP:0002905)3.24515618
26Abnormality of permanent molar morphology (HP:0011071)3.19256380
27Abnormality of the dental root (HP:0006486)3.19256380
28Taurodontia (HP:0000679)3.19256380
29Concave nail (HP:0001598)3.17067379
30Acanthosis nigricans (HP:0000956)3.16721072
31Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.16285907
32Nail dystrophy (HP:0008404)3.12577397
33Atrophic scars (HP:0001075)3.05704872
34Erythroderma (HP:0001019)3.02681408
35Renal salt wasting (HP:0000127)3.00277586
36Tubular atrophy (HP:0000092)2.97738353
37Abnormality of molar morphology (HP:0011070)2.93794177
38Abnormality of molar (HP:0011077)2.93794177
39Abnormality of the dental pulp (HP:0006479)2.90919613
40Erythema (HP:0010783)2.85313332
41Hypoplasia of the uterus (HP:0000013)2.81080802
42Hyporeflexia of lower limbs (HP:0002600)2.80338296
43Absent eyelashes (HP:0000561)2.75919229
44Ridged nail (HP:0001807)2.71463212
45Conjunctival hamartoma (HP:0100780)2.69795175
46Thick nail (HP:0001805)2.68558950
47Advanced eruption of teeth (HP:0006288)2.66023714
48Myopathic facies (HP:0002058)2.65148021
49Abnormal blistering of the skin (HP:0008066)2.64818806
50Corneal erosion (HP:0200020)2.57919728
51Selective tooth agenesis (HP:0001592)2.53964075
52Vascular calcification (HP:0004934)2.51664500
53Curly hair (HP:0002212)2.47392012
54Hypoplastic labia majora (HP:0000059)2.46684860
55Hypohidrosis (HP:0000966)2.45864396
56Abnormality of the 2nd finger (HP:0004100)2.45801786
57Hypoplasia of dental enamel (HP:0006297)2.37785513
58Chronic bronchitis (HP:0004469)2.37549450
59Dry hair (HP:0011359)2.35340189
60Oligodontia (HP:0000677)2.34770461
61Abnormality of renin-angiotensin system (HP:0000847)2.33732501
62Cardiovascular calcification (HP:0011915)2.32419357
63Hyperaldosteronism (HP:0000859)2.30380886
64Popliteal pterygium (HP:0009756)2.30238307
65Furrowed tongue (HP:0000221)2.28937067
66Abnormal hemoglobin (HP:0011902)2.28150916
67Abnormality of hair growth rate (HP:0011363)2.26572389
68Slow-growing hair (HP:0002217)2.26572389
69Goiter (HP:0000853)2.24963780
70Natal tooth (HP:0000695)2.24766481
71Abnormality of the middle phalanges of the toes (HP:0010183)2.24485848
72Ventricular tachycardia (HP:0004756)2.24445849
73Sparse eyelashes (HP:0000653)2.22434669
74Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.21695602
75Decreased circulating renin level (HP:0003351)2.21090449
76Rectal prolapse (HP:0002035)2.20807680
77Abnormality of chloride homeostasis (HP:0011422)2.20193166
78Abnormality of the labia majora (HP:0012881)2.19115370
79Distal lower limb muscle weakness (HP:0009053)2.15911770
80Oral leukoplakia (HP:0002745)2.14941197
81Blepharitis (HP:0000498)2.14754979
82Malnutrition (HP:0004395)2.14516830
83Hyperkalemia (HP:0002153)2.10989364
84Abnormality of the phalanges of the 2nd finger (HP:0009541)2.09393240
85Alopecia of scalp (HP:0002293)2.07199081
86Sparse scalp hair (HP:0002209)2.07006308
87Complement deficiency (HP:0004431)2.05979805
88Absent hair (HP:0002298)2.05460614
89Hypoplastic nipples (HP:0002557)2.02265186
90Ectropion (HP:0000656)2.02249137
91Aplasia/hypoplasia of the uterus (HP:0008684)2.02016196
92Dehydration (HP:0001944)2.00118772
93Brittle hair (HP:0002299)1.99906495
94Anhidrosis (HP:0000970)1.98051135
95Germ cell neoplasia (HP:0100728)1.97324284
96Depressed nasal tip (HP:0000437)1.97311066
97Aortic aneurysm (HP:0004942)1.96938053
98Abnormality of the gastric mucosa (HP:0004295)1.96804851
99Duplicated collecting system (HP:0000081)1.94327536
100Symphalangism affecting the phalanges of the hand (HP:0009773)1.90936910
101Facial diplegia (HP:0001349)1.87415155
102Sparse lateral eyebrow (HP:0005338)1.85412083
103Potter facies (HP:0002009)1.85269551
104Facial shape deformation (HP:0011334)1.85269551
105Palmoplantar keratoderma (HP:0000982)1.84822233
106Hand muscle atrophy (HP:0009130)1.84545419
107Choroideremia (HP:0001139)1.84442367
108Short hallux (HP:0010109)1.84294938
109Flat acetabular roof (HP:0003180)1.83108646
110Labial hypoplasia (HP:0000066)1.82925150
111Broad face (HP:0000283)1.82810521
112Abnormality of the distal phalanges of the toes (HP:0010182)1.81968321
113Glomerulosclerosis (HP:0000096)1.81615876
114Pterygium (HP:0001059)1.80091352
115Fragile skin (HP:0001030)1.79407774
116Premature skin wrinkling (HP:0100678)1.78642718
117Nasolacrimal duct obstruction (HP:0000579)1.78369709
118Aplasia cutis congenita (HP:0001057)1.77927619
119Anonychia (HP:0001798)1.77403055
120Fibular aplasia (HP:0002990)1.75465275
121Abnormality of the renal collecting system (HP:0004742)1.72079009
122Ventricular fibrillation (HP:0001663)1.71849889
123Hypodontia (HP:0000668)1.70874598
124Increased connective tissue (HP:0009025)1.70311739
125Urinary glycosaminoglycan excretion (HP:0003541)1.70260017
126Mucopolysacchariduria (HP:0008155)1.70260017
127Hamartoma of the eye (HP:0010568)1.68708735
128Bifid scrotum (HP:0000048)1.66827966
129Conical tooth (HP:0000698)1.66315800
130Pruritus (HP:0000989)1.65632911
131Hyperactive renin-angiotensin system (HP:0000841)1.65430665
132Abnormality of the salivary glands (HP:0010286)1.65379067
133Intention tremor (HP:0002080)1.64763623
134Upper limb amyotrophy (HP:0009129)1.64161935
135Distal upper limb amyotrophy (HP:0007149)1.64161935
136Thin bony cortex (HP:0002753)1.63675624
137Stridor (HP:0010307)1.63650356
138Focal segmental glomerulosclerosis (HP:0000097)1.63399595
139Steatorrhea (HP:0002570)1.63312881
140Congenital, generalized hypertrichosis (HP:0004540)1.62433282
141Abnormality of the renal cortex (HP:0011035)1.60771781
142Renal dysplasia (HP:0000110)1.60183351
143Hypoplastic female external genitalia (HP:0012815)1.59963304
144Tongue fasciculations (HP:0001308)1.59623751

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST44.53295223
2AKT33.92539033
3ERN13.53441797
4MAPKAPK33.31115040
5MST1R3.18264808
6LATS13.17265950
7FER3.13662969
8MAP3K32.63460360
9TAOK32.56609317
10PIK3CG2.46382761
11STK392.38336430
12BCKDK2.30792817
13TRIB32.26624936
14MAP3K22.24230510
15SIK12.12959826
16EEF2K2.04242751
17LRRK21.89673069
18MYLK1.85629823
19FRK1.84983148
20TTN1.77672092
21RPS6KB21.73522447
22EPHA21.73393955
23EPHB21.73110709
24MUSK1.69558996
25WNK41.58167312
26TRPM71.53117045
27OXSR11.35825675
28TNK21.32610729
29MET1.29053276
30PTK61.28724854
31IRAK31.28041300
32NME11.26880553
33MAP3K61.25407590
34SMG11.25022987
35LMTK21.22250466
36RIPK11.19843244
37PRKD31.17537563
38MAP2K21.10852390
39EPHB11.10355399
40PRKD21.09771132
41STK101.07434653
42FGFR21.05497809
43EPHA31.04463398
44DMPK1.03857766
45PAK21.03688855
46PDK21.03575576
47CHUK1.01128443
48TGFBR11.00709623
49GRK10.99768850
50INSRR0.97930737
51MAP3K90.97023063
52MAPKAPK50.90570315
53PTK20.85415782
54FGFR40.83969963
55PRKCI0.78458751
56DDR20.78390452
57STK38L0.77393727
58PIK3CA0.76517967
59PAK40.75740879
60PKN20.75359721
61TESK10.70807958
62ERBB20.69342350
63TAOK10.67523682
64MAP3K70.66342061
65CDK120.65806168
66BCR0.65522769
67NEK60.65303860
68CAMK1D0.64527805
69MATK0.63498675
70PDGFRA0.63378980
71DYRK1B0.61816921
72JAK20.61471319
73FGFR30.58936253
74HIPK20.58485481
75ERBB30.57213512
76RET0.57120958
77MAP2K30.56308791
78GRK60.55016164
79SIK30.53598514
80MAP2K10.53534325
81CDK70.53467881
82MAPK150.52909030
83STK30.51915550
84PRKCE0.51545770
85MAP3K10.51075060
86WNK30.50855102
87PDK30.49646260
88PDK40.49646260
89TGFBR20.49250180
90PRKD10.47987157
91TYK20.47397558
92ICK0.46821521
93CDK80.46141215
94BMX0.45362467
95PNCK0.45015703
96CASK0.44468158
97MAPKAPK20.44085722
98MTOR0.42937770
99LATS20.40741263
100JAK10.39367794
101CDK60.39311627
102FGFR10.39205203
103IRAK10.38116267
104PRKAA20.37536281
105PHKG10.37415496
106PHKG20.37415496
107GSK3A0.36376563
108STK240.36152130
109ILK0.35255131
110PAK30.34308525
111CSNK1A10.34055162
112IKBKB0.33507672
113MAP3K120.33471553
114RPS6KA20.32043067
115CAMK2G0.31411583
116WNK10.31336564
117EGFR0.31240410
118ROCK10.31174844
119EIF2AK10.30965117
120CAMK1G0.30643574
121STK380.30029882
122PDGFRB0.29049480
123CDC42BPA0.28934400
124IRAK20.28713553
125MAPK80.28247079
126CAMK2B0.27282168
127RPS6KA60.27261554
128CAMK2D0.26730695
129MAP2K60.26676115
130RPS6KB10.26429643
131MAP2K40.25577297
132SRC0.24924926
133BMPR1B0.24610489
134RPS6KA40.24169176
135RIPK40.23769778
136RPS6KA10.22942457
137NUAK10.22617259
138MARK20.22589141
139MAPK70.22363832
140PIM20.22288133
141MAP3K140.18480567

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009202.94625221
2Cyanoamino acid metabolism_Homo sapiens_hsa004602.82719613
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.82411562
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.53443987
5Pancreatic secretion_Homo sapiens_hsa049722.12266011
6Protein digestion and absorption_Homo sapiens_hsa049742.09256093
7Other glycan degradation_Homo sapiens_hsa005112.04452751
8Arachidonic acid metabolism_Homo sapiens_hsa005902.03595306
9Fat digestion and absorption_Homo sapiens_hsa049752.00730413
10Thyroid hormone synthesis_Homo sapiens_hsa049181.99434467
11Linoleic acid metabolism_Homo sapiens_hsa005911.98647944
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.88188554
13ABC transporters_Homo sapiens_hsa020101.88048597
14Sphingolipid metabolism_Homo sapiens_hsa006001.84262065
15Notch signaling pathway_Homo sapiens_hsa043301.74506100
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.70314244
17Steroid hormone biosynthesis_Homo sapiens_hsa001401.65169989
18Tyrosine metabolism_Homo sapiens_hsa003501.63083494
19Fatty acid degradation_Homo sapiens_hsa000711.60819758
20Phenylalanine metabolism_Homo sapiens_hsa003601.57575563
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.51545925
22Ovarian steroidogenesis_Homo sapiens_hsa049131.49471178
23Glycerolipid metabolism_Homo sapiens_hsa005611.48676808
24Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.45102676
25Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.43470820
26Pentose and glucuronate interconversions_Homo sapiens_hsa000401.40334009
27PPAR signaling pathway_Homo sapiens_hsa033201.35217784
28Nitrogen metabolism_Homo sapiens_hsa009101.33552258
29ECM-receptor interaction_Homo sapiens_hsa045121.26542508
30Vitamin digestion and absorption_Homo sapiens_hsa049771.21551611
31Mineral absorption_Homo sapiens_hsa049781.21407188
32Fatty acid metabolism_Homo sapiens_hsa012121.20595069
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.20259134
34Salivary secretion_Homo sapiens_hsa049701.19679132
35Tight junction_Homo sapiens_hsa045301.17304788
36Propanoate metabolism_Homo sapiens_hsa006401.16555365
37Axon guidance_Homo sapiens_hsa043601.14918683
38beta-Alanine metabolism_Homo sapiens_hsa004101.13979295
39Lysosome_Homo sapiens_hsa041421.13350463
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12559809
41Circadian rhythm_Homo sapiens_hsa047101.11698478
42Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.09106948
43Histidine metabolism_Homo sapiens_hsa003401.05903271
44Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.04544848
45Gastric acid secretion_Homo sapiens_hsa049711.03559130
46Adherens junction_Homo sapiens_hsa045201.02135195
47Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.02062956
48Chemical carcinogenesis_Homo sapiens_hsa052041.01877218
49Choline metabolism in cancer_Homo sapiens_hsa052311.00472352
50Phototransduction_Homo sapiens_hsa047441.00422340
51Basal cell carcinoma_Homo sapiens_hsa052171.00266346
52Fatty acid biosynthesis_Homo sapiens_hsa000610.99510005
53Bladder cancer_Homo sapiens_hsa052190.99409708
54Glutathione metabolism_Homo sapiens_hsa004800.98045002
55Steroid biosynthesis_Homo sapiens_hsa001000.95654538
56Hippo signaling pathway_Homo sapiens_hsa043900.93665308
57Autoimmune thyroid disease_Homo sapiens_hsa053200.90755563
58Fatty acid elongation_Homo sapiens_hsa000620.86513628
59Fructose and mannose metabolism_Homo sapiens_hsa000510.86504369
60Caffeine metabolism_Homo sapiens_hsa002320.84479588
61Taste transduction_Homo sapiens_hsa047420.82857845
62Renin-angiotensin system_Homo sapiens_hsa046140.82793155
63Vascular smooth muscle contraction_Homo sapiens_hsa042700.82536340
64Proteoglycans in cancer_Homo sapiens_hsa052050.81230849
65Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80557163
66Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.80158491
67Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.78909490
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78052304
69Insulin resistance_Homo sapiens_hsa049310.75231538
70Protein export_Homo sapiens_hsa030600.73681586
71Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.71477933
72Leukocyte transendothelial migration_Homo sapiens_hsa046700.69118494
73Insulin signaling pathway_Homo sapiens_hsa049100.68579780
74Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.68505182
75Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67141861
76Amoebiasis_Homo sapiens_hsa051460.67008134
77Ribosome_Homo sapiens_hsa030100.66854250
78Renin secretion_Homo sapiens_hsa049240.66634240
79Vibrio cholerae infection_Homo sapiens_hsa051100.65750792
80Arginine and proline metabolism_Homo sapiens_hsa003300.65009296
81Ether lipid metabolism_Homo sapiens_hsa005650.64983272
82Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64960562
83VEGF signaling pathway_Homo sapiens_hsa043700.64678777
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.64561671
85Melanogenesis_Homo sapiens_hsa049160.63565729
86Thyroid cancer_Homo sapiens_hsa052160.63327962
87Tryptophan metabolism_Homo sapiens_hsa003800.62744102
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61149668
89Focal adhesion_Homo sapiens_hsa045100.60987509
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59984835
91Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59705989
92ErbB signaling pathway_Homo sapiens_hsa040120.59651681
93Dorso-ventral axis formation_Homo sapiens_hsa043200.58585778
94N-Glycan biosynthesis_Homo sapiens_hsa005100.56959687
95mTOR signaling pathway_Homo sapiens_hsa041500.56445142
96Hepatitis C_Homo sapiens_hsa051600.55739496
97Lysine degradation_Homo sapiens_hsa003100.55267082
98Glucagon signaling pathway_Homo sapiens_hsa049220.54630374
99Arginine biosynthesis_Homo sapiens_hsa002200.53248057
100Endometrial cancer_Homo sapiens_hsa052130.52962734
101Staphylococcus aureus infection_Homo sapiens_hsa051500.52228705
102Peroxisome_Homo sapiens_hsa041460.51977195
103Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.50737490
104Estrogen signaling pathway_Homo sapiens_hsa049150.50643808
105Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49632372
106Toxoplasmosis_Homo sapiens_hsa051450.48488534
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47821940
108TGF-beta signaling pathway_Homo sapiens_hsa043500.47788281
109Collecting duct acid secretion_Homo sapiens_hsa049660.46231362
110Prostate cancer_Homo sapiens_hsa052150.44119893
111GnRH signaling pathway_Homo sapiens_hsa049120.44019583
112Drug metabolism - other enzymes_Homo sapiens_hsa009830.43140352
113Prolactin signaling pathway_Homo sapiens_hsa049170.42623456
114Small cell lung cancer_Homo sapiens_hsa052220.42046534
115Butanoate metabolism_Homo sapiens_hsa006500.41647496
116Retinol metabolism_Homo sapiens_hsa008300.40810236
117Inositol phosphate metabolism_Homo sapiens_hsa005620.39943675
118Maturity onset diabetes of the young_Homo sapiens_hsa049500.39879928
119Insulin secretion_Homo sapiens_hsa049110.39865984
120Bile secretion_Homo sapiens_hsa049760.39571041
121AMPK signaling pathway_Homo sapiens_hsa041520.38449635
122Primary bile acid biosynthesis_Homo sapiens_hsa001200.36572160
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.35629156
124Endocytosis_Homo sapiens_hsa041440.35056576
1252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.34626942
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.33831438
127Phosphatidylinositol signaling system_Homo sapiens_hsa040700.33123875
128Acute myeloid leukemia_Homo sapiens_hsa052210.33030019
129Platelet activation_Homo sapiens_hsa046110.31527201
130Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.30708729
131Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.30137076
132Hedgehog signaling pathway_Homo sapiens_hsa043400.29924951
133Glycosaminoglycan degradation_Homo sapiens_hsa005310.29372566

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