ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	4.44075333
2	L-fucose catabolic process (GO:0042355)	4.19789126
3	fucose catabolic process (GO:0019317)	4.19789126
4	L-fucose metabolic process (GO:0042354)	4.19789126
5	protein-cofactor linkage (GO:0018065)	4.12176282
6	behavioral response to nicotine (GO:0035095)	4.03361420
7	cornea development in camera-type eye (GO:0061303)	3.97872460
8	indolalkylamine metabolic process (GO:0006586)	3.95207977
9	platelet dense granule organization (GO:0060155)	3.89542175
10	cellular ketone body metabolic process (GO:0046950)	3.76735727
11	rRNA catabolic process (GO:0016075)	3.65061335
12	indole-containing compound catabolic process (GO:0042436)	3.64540101
13	indolalkylamine catabolic process (GO:0046218)	3.64540101
14	tryptophan catabolic process (GO:0006569)	3.64540101
15	kynurenine metabolic process (GO:0070189)	3.60144444
16	tryptophan metabolic process (GO:0006568)	3.58456190
17	water-soluble vitamin biosynthetic process (GO:0042364)	3.54765964
18	mannosylation (GO:0097502)	3.53825647
19	regulation of glucokinase activity (GO:0033131)	3.48536644
20	regulation of hexokinase activity (GO:1903299)	3.48536644
21	detection of light stimulus involved in sensory perception (GO:0050962)	3.48096967
22	detection of light stimulus involved in visual perception (GO:0050908)	3.48096967
23	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.36286498
24	preassembly of GPI anchor in ER membrane (GO:0016254)	3.29360793
25	ketone body metabolic process (GO:1902224)	3.27139007
26	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.23403754
27	protein complex biogenesis (GO:0070271)	3.20755521
28	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.18370855
29	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.18370855
30	NADH dehydrogenase complex assembly (GO:0010257)	3.18370855
31	neural tube formation (GO:0001841)	3.14696969
32	axoneme assembly (GO:0035082)	3.12714483
33	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.10543747
34	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.09747426
35	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.09747426
36	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.07358510
37	response to pheromone (GO:0019236)	2.97227431
38	piRNA metabolic process (GO:0034587)	2.96707976
39	mitochondrial respiratory chain complex assembly (GO:0033108)	2.96126661
40	DNA methylation involved in gamete generation (GO:0043046)	2.96040572
41	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.94768644
42	protein polyglutamylation (GO:0018095)	2.91516410
43	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.89224057
44	rRNA methylation (GO:0031167)	2.87112649
45	indole-containing compound metabolic process (GO:0042430)	2.85899985
46	ubiquinone biosynthetic process (GO:0006744)	2.81516272
47	rRNA modification (GO:0000154)	2.79713938
48	photoreceptor cell development (GO:0042461)	2.75884984
49	amino acid salvage (GO:0043102)	2.73551744
50	L-methionine salvage (GO:0071267)	2.73551744
51	L-methionine biosynthetic process (GO:0071265)	2.73551744
52	cellular response to ATP (GO:0071318)	2.72484232
53	positive regulation of prostaglandin secretion (GO:0032308)	2.71174206
54	pseudouridine synthesis (GO:0001522)	2.71056989
55	tRNA processing (GO:0008033)	2.67874709
56	positive regulation of defense response to virus by host (GO:0002230)	2.66018101
57	centriole replication (GO:0007099)	2.64887229
58	synapsis (GO:0007129)	2.62685312
59	behavioral response to ethanol (GO:0048149)	2.62213216
60	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.61887902
61	rhodopsin mediated signaling pathway (GO:0016056)	2.61104800
62	positive regulation of fatty acid transport (GO:2000193)	2.60390585
63	nucleotide transmembrane transport (GO:1901679)	2.59933739
64	ubiquinone metabolic process (GO:0006743)	2.59811017
65	C-terminal protein lipidation (GO:0006501)	2.59282339
66	photoreceptor cell maintenance (GO:0045494)	2.59277270
67	respiratory chain complex IV assembly (GO:0008535)	2.58593083
68	alanine transport (GO:0032328)	2.57380111
69	replication fork processing (GO:0031297)	2.56037783
70	methionine biosynthetic process (GO:0009086)	2.53557215
71	positive regulation of histone H3-K4 methylation (GO:0051571)	2.53318572
72	GPI anchor metabolic process (GO:0006505)	2.52507346
73	reciprocal meiotic recombination (GO:0007131)	2.51089701
74	reciprocal DNA recombination (GO:0035825)	2.51089701
75	inositol phosphate catabolic process (GO:0071545)	2.50096265
76	tRNA modification (GO:0006400)	2.49794002
77	C-terminal protein amino acid modification (GO:0018410)	2.49563825
78	protein K6-linked ubiquitination (GO:0085020)	2.47651660
79	eye photoreceptor cell development (GO:0042462)	2.47552613
80	epithelial cilium movement (GO:0003351)	2.47229266
81	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.45831239
82	cytochrome complex assembly (GO:0017004)	2.45730947
83	neuronal action potential (GO:0019228)	2.44644499
84	peptidyl-histidine modification (GO:0018202)	2.43260320
85	regulation of memory T cell differentiation (GO:0043380)	2.42465324
86	NAD biosynthetic process (GO:0009435)	2.40476591
87	S-adenosylmethionine metabolic process (GO:0046500)	2.39789752
88	DNA integration (GO:0015074)	2.39660636
89	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.39339384
90	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.39339384
91	kidney morphogenesis (GO:0060993)	2.39222125
92	dopamine transport (GO:0015872)	2.38780215
93	somite development (GO:0061053)	2.38724762
94	polyol catabolic process (GO:0046174)	2.38295497
95	sulfation (GO:0051923)	2.36920660
96	male meiosis I (GO:0007141)	2.36230157
97	DNA double-strand break processing (GO:0000729)	2.36161230
98	double-strand break repair via homologous recombination (GO:0000724)	2.33877654
99	recombinational repair (GO:0000725)	2.33255586
100	negative regulation of telomere maintenance (GO:0032205)	2.33111655

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.01013782
2	VDR_22108803_ChIP-Seq_LS180_Human	3.23373819
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.74845368
4	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.62330153
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.61130846
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.57316228
7	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.40841485
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.39993974
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.38010978
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.36347433
11	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.33500331
12	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.27036809
13	GBX2_23144817_ChIP-Seq_PC3_Human	2.26387538
14	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.24780372
15	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.23363067
16	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.22419190
17	EWS_26573619_Chip-Seq_HEK293_Human	2.12428239
18	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.11817593
19	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.06454720
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.93380830
21	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.92520930
22	VDR_23849224_ChIP-Seq_CD4+_Human	1.92474662
23	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.92263097
24	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.92222394
25	FUS_26573619_Chip-Seq_HEK293_Human	1.88133301
26	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.86744994
27	TP53_22573176_ChIP-Seq_HFKS_Human	1.85062678
28	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.80202450
29	TAF15_26573619_Chip-Seq_HEK293_Human	1.73544243
30	IRF1_19129219_ChIP-ChIP_H3396_Human	1.68757585
31	P300_19829295_ChIP-Seq_ESCs_Human	1.67568833
32	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.64878276
33	ELK1_19687146_ChIP-ChIP_HELA_Human	1.62124803
34	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.55465942
35	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.55366736
36	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.55351687
37	MYC_18940864_ChIP-ChIP_HL60_Human	1.52553928
38	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.42960349
39	CBP_20019798_ChIP-Seq_JUKART_Human	1.42960349
40	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.38832906
41	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.38688477
42	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.38688477
43	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.33867551
44	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.31456776
45	AR_20517297_ChIP-Seq_VCAP_Human	1.31170196
46	SOX2_19829295_ChIP-Seq_ESCs_Human	1.30735418
47	NANOG_19829295_ChIP-Seq_ESCs_Human	1.30735418
48	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.30572654
49	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.29992341
50	FOXP3_21729870_ChIP-Seq_TREG_Human	1.28658260
51	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.28224536
52	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.28200642
53	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.28107415
54	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.27644659
55	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.27485509
56	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.26722541
57	STAT3_23295773_ChIP-Seq_U87_Human	1.25842825
58	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.24771166
59	BCAT_22108803_ChIP-Seq_LS180_Human	1.23067289
60	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.21591776
61	EZH2_22144423_ChIP-Seq_EOC_Human	1.20016498
62	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.19723591
63	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.19454199
64	TCF4_23295773_ChIP-Seq_U87_Human	1.17795165
65	NCOR_22424771_ChIP-Seq_293T_Human	1.17441285
66	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.16789592
67	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.16744255
68	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.13228534
69	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.12074305
70	AR_25329375_ChIP-Seq_VCAP_Human	1.11969857
71	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.11083654
72	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.10693336
73	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.10253494
74	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.08775803
75	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.07225236
76	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.07131214
77	P53_22387025_ChIP-Seq_ESCs_Mouse	1.06960091
78	SMAD4_21799915_ChIP-Seq_A2780_Human	1.05629867
79	HOXB7_26014856_ChIP-Seq_BT474_Human	1.05592497
80	GATA3_26560356_Chip-Seq_TH2_Human	1.05530959
81	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.05337177
82	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.05155370
83	TCF4_22108803_ChIP-Seq_LS180_Human	1.04545990
84	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.04314674
85	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.03155501
86	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.01464514
87	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.00930003
88	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.00836543
89	HTT_18923047_ChIP-ChIP_STHdh_Human	0.99841097
90	ETV1_20927104_ChIP-Seq_GIST48_Human	0.99217645
91	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.98184880
92	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.98020393
93	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.96740341
94	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.95520034
95	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.95341926
96	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.94683586
97	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.94244213
98	RUNX2_22187159_ChIP-Seq_PCA_Human	0.93912268
99	ELF1_17652178_ChIP-ChIP_JURKAT_Human	0.93273147
100	PHF8_20622853_ChIP-Seq_HELA_Human	0.93088924

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.64176623
2	MP0004147_increased_porphyrin_level	2.84989277
3	MP0003195_calcinosis	2.82414661
4	MP0002837_dystrophic_cardiac_calcinosis	2.73842550
5	MP0006292_abnormal_olfactory_placode	2.41346909
6	MP0001986_abnormal_taste_sensitivity	2.33868290
7	MP0005646_abnormal_pituitary_gland	2.32180692
8	MP0002102_abnormal_ear_morphology	2.30184046
9	MP0005551_abnormal_eye_electrophysiolog	2.28780494
10	MP0005645_abnormal_hypothalamus_physiol	2.19968403
11	MP0003787_abnormal_imprinting	2.16725921
12	MP0000569_abnormal_digit_pigmentation	2.15792711
13	MP0002876_abnormal_thyroid_physiology	2.11838116
14	MP0008875_abnormal_xenobiotic_pharmacok	2.10309552
15	MP0002638_abnormal_pupillary_reflex	2.08120398
16	MP0008995_early_reproductive_senescence	2.00670815
17	MP0001968_abnormal_touch/_nociception	2.00195763
18	MP0008872_abnormal_physiological_respon	1.96610599
19	MP0006072_abnormal_retinal_apoptosis	1.76438733
20	MP0009046_muscle_twitch	1.74071013
21	MP0000372_irregular_coat_pigmentation	1.69471832
22	MP0002160_abnormal_reproductive_system	1.69026917
23	MP0004145_abnormal_muscle_electrophysio	1.66421615
24	MP0005253_abnormal_eye_physiology	1.62138957
25	MP0008058_abnormal_DNA_repair	1.54995706
26	MP0005084_abnormal_gallbladder_morpholo	1.53771520
27	MP0004142_abnormal_muscle_tone	1.53178971
28	MP0002277_abnormal_respiratory_mucosa	1.49909265
29	MP0002254_reproductive_system_inflammat	1.47179304
30	MP0004885_abnormal_endolymph	1.44470664
31	MP0002736_abnormal_nociception_after	1.44466279
32	MP0005410_abnormal_fertilization	1.42153971
33	MP0001764_abnormal_homeostasis	1.40569293
34	MP0002693_abnormal_pancreas_physiology	1.38812451
35	MP0003786_premature_aging	1.38404668
36	MP0005389_reproductive_system_phenotype	1.37154456
37	MP0005379_endocrine/exocrine_gland_phen	1.36792043
38	MP0009745_abnormal_behavioral_response	1.35160087
39	MP0001502_abnormal_circadian_rhythm	1.34284734
40	MP0003646_muscle_fatigue	1.31865443
41	MP0003880_abnormal_central_pattern	1.31049498
42	MP0005174_abnormal_tail_pigmentation	1.30267651
43	MP0005332_abnormal_amino_acid	1.26564968
44	MP0008789_abnormal_olfactory_epithelium	1.25510408
45	MP0001501_abnormal_sleep_pattern	1.25339636
46	MP0002938_white_spotting	1.25260650
47	MP0002163_abnormal_gland_morphology	1.23125931
48	MP0004043_abnormal_pH_regulation	1.19212316
49	MP0000631_abnormal_neuroendocrine_gland	1.17086032
50	MP0002653_abnormal_ependyma_morphology	1.16949659
51	MP0009697_abnormal_copulation	1.13336914
52	MP0001873_stomach_inflammation	1.11971793
53	MP0001919_abnormal_reproductive_system	1.11822794
54	MP0006276_abnormal_autonomic_nervous	1.11375704
55	MP0002928_abnormal_bile_duct	1.11086762
56	MP0004133_heterotaxia	1.10358557
57	MP0002272_abnormal_nervous_system	1.06212297
58	MP0000427_abnormal_hair_cycle	1.03801778
59	MP0003011_delayed_dark_adaptation	1.00717823
60	MP0005671_abnormal_response_to	1.00579953
61	MP0006036_abnormal_mitochondrial_physio	0.95118419
62	MP0001486_abnormal_startle_reflex	0.94256187
63	MP0003718_maternal_effect	0.93995798
64	MP0002095_abnormal_skin_pigmentation	0.93520792
65	MP0001944_abnormal_pancreas_morphology	0.93238969
66	MP0001929_abnormal_gametogenesis	0.92181511
67	MP0002064_seizures	0.91751850
68	MP0005085_abnormal_gallbladder_physiolo	0.89956347
69	MP0004134_abnormal_chest_morphology	0.89430476
70	MP0001984_abnormal_olfaction	0.88517230
71	MP0002557_abnormal_social/conspecific_i	0.87248188
72	MP0003121_genomic_imprinting	0.86941986
73	MP0003698_abnormal_male_reproductive	0.86870463
74	MP0005075_abnormal_melanosome_morpholog	0.86530394
75	MP0002229_neurodegeneration	0.86109014
76	MP0003283_abnormal_digestive_organ	0.85986208
77	MP0005365_abnormal_bile_salt	0.85793876
78	MP0005220_abnormal_exocrine_pancreas	0.85696558
79	MP0005310_abnormal_salivary_gland	0.84859525
80	MP0005195_abnormal_posterior_eye	0.82955530
81	MP0010329_abnormal_lipoprotein_level	0.82668324
82	MP0000230_abnormal_systemic_arterial	0.82558785
83	MP0005360_urolithiasis	0.82092862
84	MP0000383_abnormal_hair_follicle	0.81653796
85	MP0008775_abnormal_heart_ventricle	0.81384213
86	MP0004215_abnormal_myocardial_fiber	0.80050818
87	MP0005499_abnormal_olfactory_system	0.78686456
88	MP0005394_taste/olfaction_phenotype	0.78686456
89	MP0005636_abnormal_mineral_homeostasis	0.78584211
90	MP0000613_abnormal_salivary_gland	0.76972641
91	MP0000470_abnormal_stomach_morphology	0.76866717
92	MP0002572_abnormal_emotion/affect_behav	0.76529125
93	MP0009764_decreased_sensitivity_to	0.75103716
94	MP0006035_abnormal_mitochondrial_morpho	0.74999865
95	MP0000653_abnormal_sex_gland	0.74458112
96	MP0003252_abnormal_bile_duct	0.74317332
97	MP0005167_abnormal_blood-brain_barrier	0.73918644
98	MP0002733_abnormal_thermal_nociception	0.73773549
99	MP0001905_abnormal_dopamine_level	0.73766562
100	MP0003136_yellow_coat_color	0.73633445

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Type II lissencephaly (HP:0007260)	3.98074933
2	Pancreatic cysts (HP:0001737)	3.94456275
3	Pancreatic fibrosis (HP:0100732)	3.70424608
4	Congenital stationary night blindness (HP:0007642)	3.61673279
5	Molar tooth sign on MRI (HP:0002419)	3.57554319
6	Abnormality of midbrain morphology (HP:0002418)	3.57554319
7	Attenuation of retinal blood vessels (HP:0007843)	3.41152725
8	True hermaphroditism (HP:0010459)	3.39253472
9	Abnormality of the renal cortex (HP:0011035)	3.33409331
10	Nephronophthisis (HP:0000090)	3.30682880
11	Lipid accumulation in hepatocytes (HP:0006561)	3.01608186
12	Chronic hepatic failure (HP:0100626)	2.90656368
13	Tubular atrophy (HP:0000092)	2.86663854
14	Cerebellar dysplasia (HP:0007033)	2.84209192
15	Abnormality of the renal medulla (HP:0100957)	2.83167130
16	Renal cortical cysts (HP:0000803)	2.71596013
17	Lissencephaly (HP:0001339)	2.66039943
18	Large for gestational age (HP:0001520)	2.66014813
19	Polydipsia (HP:0001959)	2.65458324
20	Abnormal drinking behavior (HP:0030082)	2.65458324
21	Abnormality of alanine metabolism (HP:0010916)	2.59200952
22	Hyperalaninemia (HP:0003348)	2.59200952
23	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.59200952
24	Abnormal rod and cone electroretinograms (HP:0008323)	2.55591789
25	Medial flaring of the eyebrow (HP:0010747)	2.52583673
26	Abnormality of the pons (HP:0007361)	2.50106840
27	Increased hepatocellular lipid droplets (HP:0006565)	2.49032521
28	Abolished electroretinogram (ERG) (HP:0000550)	2.48825799
29	Hypoplasia of the pons (HP:0012110)	2.48285579
30	Increased CSF lactate (HP:0002490)	2.45097320
31	Methylmalonic acidemia (HP:0002912)	2.41342582
32	Mitochondrial inheritance (HP:0001427)	2.36491689
33	Hypothermia (HP:0002045)	2.34456218
34	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.31900850
35	Hyperventilation (HP:0002883)	2.28029425
36	Bony spicule pigmentary retinopathy (HP:0007737)	2.23485773
37	Acute necrotizing encephalopathy (HP:0006965)	2.23129606
38	Ketoacidosis (HP:0001993)	2.21370515
39	Pendular nystagmus (HP:0012043)	2.21070928
40	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.20350995
41	Bile duct proliferation (HP:0001408)	2.18635035
42	Abnormal biliary tract physiology (HP:0012439)	2.18635035
43	Retinal dysplasia (HP:0007973)	2.17499764
44	Abnormality of DNA repair (HP:0003254)	2.15851919
45	Asplenia (HP:0001746)	2.13983166
46	Cystic liver disease (HP:0006706)	2.12999345
47	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.12106021
48	Abnormal protein N-linked glycosylation (HP:0012347)	2.12106021
49	Abnormal protein glycosylation (HP:0012346)	2.12106021
50	Abnormal glycosylation (HP:0012345)	2.12106021
51	Ketosis (HP:0001946)	2.12104166
52	Decreased central vision (HP:0007663)	2.08310483
53	3-Methylglutaconic aciduria (HP:0003535)	2.08040107
54	Keratoconus (HP:0000563)	2.07951678
55	Increased corneal curvature (HP:0100692)	2.07951678
56	Hypoplastic iliac wings (HP:0002866)	2.05348381
57	Optic disc pallor (HP:0000543)	2.04512435
58	Polyuria (HP:0000103)	2.04437589
59	Acute encephalopathy (HP:0006846)	2.01829448
60	Methylmalonic aciduria (HP:0012120)	2.01162770
61	Male pseudohermaphroditism (HP:0000037)	2.00521114
62	Gaze-evoked nystagmus (HP:0000640)	2.00337671
63	Stomatitis (HP:0010280)	2.00127505
64	Progressive macrocephaly (HP:0004481)	2.00082680
65	Type I transferrin isoform profile (HP:0003642)	1.99782173
66	Severe muscular hypotonia (HP:0006829)	1.99212967
67	Increased serum lactate (HP:0002151)	1.99078547
68	Progressive microcephaly (HP:0000253)	1.92268576
69	Renal Fanconi syndrome (HP:0001994)	1.88993465
70	Abnormal mitochondria in muscle tissue (HP:0008316)	1.88896605
71	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.88558299
72	Azoospermia (HP:0000027)	1.88375184
73	Optic nerve hypoplasia (HP:0000609)	1.88018322
74	Hepatic necrosis (HP:0002605)	1.87839632
75	Furrowed tongue (HP:0000221)	1.87788996
76	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.84585915
77	Congenital hepatic fibrosis (HP:0002612)	1.84050753
78	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.82827680
79	Hypoplasia of the fovea (HP:0007750)	1.82752969
80	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.82752969
81	Protruding tongue (HP:0010808)	1.81865501
82	Hepatocellular necrosis (HP:0001404)	1.81222804
83	Sclerocornea (HP:0000647)	1.80348580
84	Pachygyria (HP:0001302)	1.77766876
85	Nephrogenic diabetes insipidus (HP:0009806)	1.76775235
86	Abnormality of the renal collecting system (HP:0004742)	1.74624495
87	Tachypnea (HP:0002789)	1.73188026
88	Progressive inability to walk (HP:0002505)	1.72753583
89	Lethargy (HP:0001254)	1.70933002
90	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.70863823
91	Type 2 muscle fiber atrophy (HP:0003554)	1.69991297
92	Febrile seizures (HP:0002373)	1.67981885
93	Hemiparesis (HP:0001269)	1.67893922
94	Dyskinesia (HP:0100660)	1.67337325
95	Abnormal urine output (HP:0012590)	1.67230317
96	Duplicated collecting system (HP:0000081)	1.67108180
97	Gait imbalance (HP:0002141)	1.66919776
98	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.66669432
99	Lactic acidosis (HP:0003128)	1.66639903
100	Short tibia (HP:0005736)	1.66492254

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.54628293
2	MAP4K2	3.12963251
3	ADRBK2	2.85049608
4	NUAK1	2.71116384
5	PINK1	2.67033893
6	WNK4	2.60819007
7	MAPK13	2.49754073
8	TAOK3	2.40290883
9	BMPR1B	2.33152467
10	GRK1	2.29925471
11	ZAK	2.29171021
12	WNK3	2.06652104
13	TXK	2.02870230
14	TLK1	1.78150921
15	STK39	1.77748091
16	MAP3K4	1.75895173
17	INSRR	1.68871102
18	DAPK2	1.59079484
19	OXSR1	1.57840851
20	MUSK	1.57276886
21	NME1	1.55473055
22	VRK1	1.48144181
23	ACVR1B	1.34963170
24	SRPK1	1.29445503
25	PHKG1	1.28274575
26	PHKG2	1.28274575
27	IRAK1	1.23949622
28	TNK2	1.23082135
29	BRSK2	1.19561932
30	EIF2AK3	1.18592799
31	CAMKK2	1.16498458
32	TRIM28	1.15380449
33	IKBKB	1.04355025
34	ADRBK1	1.03162730
35	VRK2	0.99675007
36	MKNK2	0.97997952
37	TEC	0.94953456
38	ITK	0.92360259
39	PRKCQ	0.91509808
40	ERBB3	0.90987176
41	MAP2K6	0.88767386
42	BCKDK	0.87992678
43	MAPK15	0.85240871
44	PRKCE	0.82299386
45	WEE1	0.82017149
46	RPS6KA5	0.79974684
47	MAP2K7	0.79965917
48	PAK3	0.78375596
49	NTRK3	0.76318835
50	PTK2B	0.75769649
51	DYRK2	0.75287665
52	TNIK	0.70367922
53	CDK3	0.68789252
54	PIK3CG	0.68428570
55	IKBKE	0.68378145
56	PNCK	0.67427323
57	TSSK6	0.66183473
58	SYK	0.65951325
59	MAP4K1	0.65390071
60	GRK7	0.64964786
61	PRKCG	0.63245691
62	MKNK1	0.61042701
63	CSNK1G3	0.60822276
64	PIK3CA	0.57625295
65	OBSCN	0.56804864
66	KIT	0.55674754
67	CSNK1A1	0.55286123
68	CSNK1G1	0.54775832
69	MARK1	0.53638807
70	MAPKAPK5	0.52838965
71	IRAK2	0.52246203
72	CSNK1G2	0.48081898
73	TGFBR1	0.46426377
74	TRPM7	0.45740748
75	PRKACA	0.44928950
76	PASK	0.43843445
77	CHEK2	0.43735112
78	AKT3	0.43266282
79	PKN1	0.43049141
80	STK3	0.42513506
81	PRKCI	0.41654278
82	IRAK4	0.41287911
83	PLK4	0.40784864
84	CASK	0.40757894
85	CHUK	0.39499300
86	PLK3	0.39155865
87	ATM	0.38436455
88	ABL1	0.38349028
89	FGFR2	0.37812399
90	ATR	0.37267344
91	CSNK1A1L	0.36572429
92	CCNB1	0.35803259
93	WNK1	0.35510441
94	MAPKAPK3	0.34784070
95	LYN	0.34563510
96	STK11	0.32691454
97	CAMK2A	0.32508006
98	PIM1	0.31692346
99	EIF2AK2	0.30822681
100	MST4	0.30392434

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.78817938
2	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.72098718
3	Butanoate metabolism_Homo sapiens_hsa00650	2.62075327
4	Phototransduction_Homo sapiens_hsa04744	2.54591554
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.52735267
6	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.44370040
7	Selenocompound metabolism_Homo sapiens_hsa00450	2.38282833
8	Protein export_Homo sapiens_hsa03060	2.23986839
9	Homologous recombination_Homo sapiens_hsa03440	2.09270309
10	Oxidative phosphorylation_Homo sapiens_hsa00190	2.04339741
11	RNA polymerase_Homo sapiens_hsa03020	2.04229444
12	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.03500517
13	Nitrogen metabolism_Homo sapiens_hsa00910	1.97725985
14	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.93953384
15	Fanconi anemia pathway_Homo sapiens_hsa03460	1.93894033
16	Tryptophan metabolism_Homo sapiens_hsa00380	1.85408729
17	Linoleic acid metabolism_Homo sapiens_hsa00591	1.83107821
18	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.72993622
19	RNA degradation_Homo sapiens_hsa03018	1.71801207
20	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.65467336
21	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.65366247
22	One carbon pool by folate_Homo sapiens_hsa00670	1.60507212
23	Basal transcription factors_Homo sapiens_hsa03022	1.58556711
24	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.57855135
25	Ether lipid metabolism_Homo sapiens_hsa00565	1.51242709
26	Parkinsons disease_Homo sapiens_hsa05012	1.50760322
27	Sulfur relay system_Homo sapiens_hsa04122	1.48061681
28	Peroxisome_Homo sapiens_hsa04146	1.45480250
29	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.43792291
30	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.41242125
31	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.38101713
32	Caffeine metabolism_Homo sapiens_hsa00232	1.37106642
33	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.36152403
34	Olfactory transduction_Homo sapiens_hsa04740	1.34900460
35	Propanoate metabolism_Homo sapiens_hsa00640	1.23931957
36	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.23902459
37	Taste transduction_Homo sapiens_hsa04742	1.23649695
38	Regulation of autophagy_Homo sapiens_hsa04140	1.20239393
39	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.13166821
40	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.08082793
41	Nicotine addiction_Homo sapiens_hsa05033	1.07378478
42	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.07255657
43	Type I diabetes mellitus_Homo sapiens_hsa04940	1.06204938
44	Primary immunodeficiency_Homo sapiens_hsa05340	1.03273444
45	Asthma_Homo sapiens_hsa05310	1.02894637
46	Huntingtons disease_Homo sapiens_hsa05016	1.01411669
47	Chemical carcinogenesis_Homo sapiens_hsa05204	1.00035069
48	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.94834367
49	Purine metabolism_Homo sapiens_hsa00230	0.94463685
50	Circadian rhythm_Homo sapiens_hsa04710	0.91599203
51	Steroid biosynthesis_Homo sapiens_hsa00100	0.91064340
52	Allograft rejection_Homo sapiens_hsa05330	0.88980571
53	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.88603799
54	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.86717829
55	Alzheimers disease_Homo sapiens_hsa05010	0.85960774
56	Pyrimidine metabolism_Homo sapiens_hsa00240	0.83861293
57	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.83614747
58	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.81169983
59	Proteasome_Homo sapiens_hsa03050	0.78927934
60	Cardiac muscle contraction_Homo sapiens_hsa04260	0.77944463
61	Sulfur metabolism_Homo sapiens_hsa00920	0.76925791
62	Retinol metabolism_Homo sapiens_hsa00830	0.73282026
63	Insulin secretion_Homo sapiens_hsa04911	0.73216899
64	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.73039704
65	Metabolic pathways_Homo sapiens_hsa01100	0.72460771
66	RNA transport_Homo sapiens_hsa03013	0.71076350
67	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.67805095
68	Glycerolipid metabolism_Homo sapiens_hsa00561	0.67583646
69	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.67220739
70	ABC transporters_Homo sapiens_hsa02010	0.67173065
71	Ribosome_Homo sapiens_hsa03010	0.66695418
72	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.64571300
73	Morphine addiction_Homo sapiens_hsa05032	0.59095973
74	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.58859820
75	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.57395464
76	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.56870418
77	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.56659932
78	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.56508616
79	Graft-versus-host disease_Homo sapiens_hsa05332	0.56295475
80	Fat digestion and absorption_Homo sapiens_hsa04975	0.54898689
81	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.54673817
82	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.52711542
83	Lysine degradation_Homo sapiens_hsa00310	0.52650494
84	Mineral absorption_Homo sapiens_hsa04978	0.51788441
85	Fatty acid degradation_Homo sapiens_hsa00071	0.49306192
86	beta-Alanine metabolism_Homo sapiens_hsa00410	0.46146497
87	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.46055288
88	Circadian entrainment_Homo sapiens_hsa04713	0.45732743
89	Nucleotide excision repair_Homo sapiens_hsa03420	0.45143957
90	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.43295714
91	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.41188735
92	Fatty acid metabolism_Homo sapiens_hsa01212	0.41105431
93	Salivary secretion_Homo sapiens_hsa04970	0.41017257
94	Mismatch repair_Homo sapiens_hsa03430	0.40547586
95	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.40292962
96	Spliceosome_Homo sapiens_hsa03040	0.37588159
97	Non-homologous end-joining_Homo sapiens_hsa03450	0.37118288
98	Serotonergic synapse_Homo sapiens_hsa04726	0.36768612
99	GABAergic synapse_Homo sapiens_hsa04727	0.34403336
100	Calcium signaling pathway_Homo sapiens_hsa04020	0.34254295

PRORSD1P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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