ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	4.50026036
2	protein K11-linked deubiquitination (GO:0035871)	4.17684103
3	cellular ketone body metabolic process (GO:0046950)	4.02296616
4	behavioral response to nicotine (GO:0035095)	3.99756960
5	glycerophospholipid catabolic process (GO:0046475)	3.78106574
6	ketone body metabolic process (GO:1902224)	3.76415297
7	protein localization to cilium (GO:0061512)	3.75481852
8	DNA deamination (GO:0045006)	3.49830878
9	fucose catabolic process (GO:0019317)	3.40932921
10	L-fucose metabolic process (GO:0042354)	3.40932921
11	L-fucose catabolic process (GO:0042355)	3.40932921
12	indole-containing compound catabolic process (GO:0042436)	3.37832174
13	indolalkylamine catabolic process (GO:0046218)	3.37832174
14	tryptophan catabolic process (GO:0006569)	3.37832174
15	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.32282626
16	kynurenine metabolic process (GO:0070189)	3.32158584
17	indolalkylamine metabolic process (GO:0006586)	3.28924685
18	presynaptic membrane assembly (GO:0097105)	3.25531888
19	tachykinin receptor signaling pathway (GO:0007217)	3.20716525
20	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.14989402
21	detection of light stimulus involved in visual perception (GO:0050908)	3.07659067
22	detection of light stimulus involved in sensory perception (GO:0050962)	3.07659067
23	retinal ganglion cell axon guidance (GO:0031290)	3.07058361
24	nonmotile primary cilium assembly (GO:0035058)	3.04327931
25	pyrimidine nucleobase catabolic process (GO:0006208)	3.04098625
26	reflex (GO:0060004)	3.03990876
27	negative regulation of heart rate (GO:0010459)	2.99553337
28	gamma-aminobutyric acid transport (GO:0015812)	2.95226734
29	tryptophan metabolic process (GO:0006568)	2.94530979
30	behavioral response to ethanol (GO:0048149)	2.94529528
31	protein-cofactor linkage (GO:0018065)	2.94444748
32	acrosome reaction (GO:0007340)	2.86691232
33	activated T cell proliferation (GO:0050798)	2.85791144
34	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.85650875
35	platelet dense granule organization (GO:0060155)	2.84521718
36	nucleobase catabolic process (GO:0046113)	2.84240023
37	regulation of hexokinase activity (GO:1903299)	2.83394070
38	regulation of glucokinase activity (GO:0033131)	2.83394070
39	axoneme assembly (GO:0035082)	2.82558790
40	DNA double-strand break processing (GO:0000729)	2.82085179
41	postsynaptic membrane organization (GO:0001941)	2.81963181
42	neuron cell-cell adhesion (GO:0007158)	2.81911490
43	preassembly of GPI anchor in ER membrane (GO:0016254)	2.81855095
44	intraciliary transport (GO:0042073)	2.80342387
45	presynaptic membrane organization (GO:0097090)	2.80299853
46	L-methionine salvage (GO:0071267)	2.80168825
47	L-methionine biosynthetic process (GO:0071265)	2.80168825
48	amino acid salvage (GO:0043102)	2.80168825
49	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	2.79983255
50	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	2.79983255
51	retinal cone cell development (GO:0046549)	2.76191616
52	startle response (GO:0001964)	2.75339203
53	negative regulation of telomere maintenance (GO:0032205)	2.75209431
54	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.71894221
55	photoreceptor cell maintenance (GO:0045494)	2.69996003
56	piRNA metabolic process (GO:0034587)	2.69659664
57	epithelial cilium movement (GO:0003351)	2.67789649
58	cilium organization (GO:0044782)	2.67452181
59	multicellular organism reproduction (GO:0032504)	2.66884360
60	cilium assembly (GO:0042384)	2.65992186
61	neural tube formation (GO:0001841)	2.65832049
62	synaptic transmission, cholinergic (GO:0007271)	2.65770954
63	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	2.65172736
64	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.64711977
65	sulfation (GO:0051923)	2.64533868
66	respiratory chain complex IV assembly (GO:0008535)	2.64158613
67	righting reflex (GO:0060013)	2.64091229
68	dendritic spine morphogenesis (GO:0060997)	2.63977762
69	regulation of action potential (GO:0098900)	2.62545079
70	methionine biosynthetic process (GO:0009086)	2.60371984
71	negative regulation of mast cell activation (GO:0033004)	2.60336018
72	intra-S DNA damage checkpoint (GO:0031573)	2.60256608
73	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	2.58832643
74	cornea development in camera-type eye (GO:0061303)	2.58730712
75	positive regulation of prostaglandin secretion (GO:0032308)	2.58534230
76	protein polyglutamylation (GO:0018095)	2.58524178
77	glycosphingolipid biosynthetic process (GO:0006688)	2.58362634
78	regulation of cilium movement (GO:0003352)	2.57642701
79	cilium morphogenesis (GO:0060271)	2.55700078
80	neuronal action potential (GO:0019228)	2.53859077
81	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.53637968
82	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.53009102
83	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.52848296
84	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.52848296
85	NADH dehydrogenase complex assembly (GO:0010257)	2.52848296
86	photoreceptor cell development (GO:0042461)	2.52149863
87	indole-containing compound metabolic process (GO:0042430)	2.52129903
88	adaptation of signaling pathway (GO:0023058)	2.51488011
89	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.51478633
90	kidney morphogenesis (GO:0060993)	2.50969860
91	vocalization behavior (GO:0071625)	2.50104211
92	protein complex biogenesis (GO:0070271)	2.49920784
93	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	2.49548526
94	auditory behavior (GO:0031223)	2.49317167
95	inositol phosphate catabolic process (GO:0071545)	2.48024306
96	C4-dicarboxylate transport (GO:0015740)	2.43052538
97	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.42856509
98	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.40822732
99	dopamine transport (GO:0015872)	2.40090087
100	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.39981215

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.42152873
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.30654720
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.20032763
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.10167588
5	VDR_22108803_ChIP-Seq_LS180_Human	3.09724546
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.87668632
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.72746383
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.57202582
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.35133662
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.32705279
11	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.13440114
12	FUS_26573619_Chip-Seq_HEK293_Human	2.13119020
13	TAF15_26573619_Chip-Seq_HEK293_Human	2.12739215
14	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.08470726
15	EWS_26573619_Chip-Seq_HEK293_Human	2.07463632
16	P300_19829295_ChIP-Seq_ESCs_Human	2.03592742
17	ER_23166858_ChIP-Seq_MCF-7_Human	1.98710037
18	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.95758584
19	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.90446717
20	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.90064440
21	EZH2_22144423_ChIP-Seq_EOC_Human	1.88840006
22	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.81427911
23	BCAT_22108803_ChIP-Seq_LS180_Human	1.72628449
24	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.70330238
25	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.69800016
26	SMAD4_21799915_ChIP-Seq_A2780_Human	1.66590015
27	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.64170646
28	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.61807285
29	STAT3_23295773_ChIP-Seq_U87_Human	1.61329883
30	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.61076485
31	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.60633182
32	AR_21572438_ChIP-Seq_LNCaP_Human	1.56418293
33	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.54574434
34	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.52653848
35	CBP_20019798_ChIP-Seq_JUKART_Human	1.52653848
36	AR_25329375_ChIP-Seq_VCAP_Human	1.51609364
37	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.49895107
38	TCF4_23295773_ChIP-Seq_U87_Human	1.49867388
39	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.46762802
40	TP53_22573176_ChIP-Seq_HFKS_Human	1.45709569
41	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.43371225
42	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.42688798
43	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.42688798
44	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.41180989
45	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.41103985
46	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.38408537
47	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.38229574
48	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.37925093
49	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.37507188
50	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.36837058
51	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.35808536
52	RNF2_27304074_Chip-Seq_NSC_Mouse	1.33161400
53	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.32211847
54	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.31781738
55	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.31314447
56	IRF1_19129219_ChIP-ChIP_H3396_Human	1.30308882
57	SOX2_19829295_ChIP-Seq_ESCs_Human	1.29731549
58	NANOG_19829295_ChIP-Seq_ESCs_Human	1.29731549
59	REST_21632747_ChIP-Seq_MESCs_Mouse	1.29312732
60	TCF4_22108803_ChIP-Seq_LS180_Human	1.29135102
61	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.29052828
62	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.27408949
63	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.25835326
64	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.24274551
65	RUNX2_22187159_ChIP-Seq_PCA_Human	1.24135937
66	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.23341415
67	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.20417284
68	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.20191017
69	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.20140508
70	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.20060618
71	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.18398272
72	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.17400527
73	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.15954533
74	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.15410800
75	MYC_18940864_ChIP-ChIP_HL60_Human	1.15199584
76	AR_20517297_ChIP-Seq_VCAP_Human	1.14567518
77	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.14529556
78	P53_22387025_ChIP-Seq_ESCs_Mouse	1.14438738
79	NCOR_22424771_ChIP-Seq_293T_Human	1.13645675
80	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.12141102
81	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.12141102
82	CDX2_22108803_ChIP-Seq_LS180_Human	1.08070021
83	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.06710159
84	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.04976236
85	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.03636846
86	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.02781085
87	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.02596447
88	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.00998907
89	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.00380446
90	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.99444507
91	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.98403650
92	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.98108326
93	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.98048777
94	ELK1_19687146_ChIP-ChIP_HELA_Human	0.97444591
95	P300_18555785_Chip-Seq_ESCs_Mouse	0.97325848
96	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.96998403
97	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.96484085
98	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	0.96040209
99	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.95982340
100	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.95056174

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002638_abnormal_pupillary_reflex	2.85808534
2	MP0001968_abnormal_touch/_nociception	2.84892038
3	MP0002138_abnormal_hepatobiliary_system	2.83230913
4	MP0003880_abnormal_central_pattern	2.79780565
5	MP0002102_abnormal_ear_morphology	2.78993827
6	MP0003195_calcinosis	2.75846308
7	MP0004885_abnormal_endolymph	2.40541510
8	MP0005551_abnormal_eye_electrophysiolog	2.29438659
9	MP0009046_muscle_twitch	2.12799087
10	MP0002736_abnormal_nociception_after	2.11705346
11	MP0005646_abnormal_pituitary_gland	2.11201276
12	MP0001984_abnormal_olfaction	2.09381085
13	MP0003011_delayed_dark_adaptation	2.08662073
14	MP0005645_abnormal_hypothalamus_physiol	1.99791645
15	MP0006072_abnormal_retinal_apoptosis	1.98897238
16	MP0005253_abnormal_eye_physiology	1.95679942
17	MP0009745_abnormal_behavioral_response	1.88298511
18	MP0008875_abnormal_xenobiotic_pharmacok	1.85698470
19	MP0000569_abnormal_digit_pigmentation	1.83157675
20	MP0006276_abnormal_autonomic_nervous	1.82952508
21	MP0010386_abnormal_urinary_bladder	1.79905788
22	MP0000427_abnormal_hair_cycle	1.79486808
23	MP0000372_irregular_coat_pigmentation	1.75421544
24	MP0001970_abnormal_pain_threshold	1.75176453
25	MP0008877_abnormal_DNA_methylation	1.72298917
26	MP0004147_increased_porphyrin_level	1.68768001
27	MP0001486_abnormal_startle_reflex	1.66715994
28	MP0002272_abnormal_nervous_system	1.65166991
29	MP0002876_abnormal_thyroid_physiology	1.63150493
30	MP0002735_abnormal_chemical_nociception	1.59197434
31	MP0005084_abnormal_gallbladder_morpholo	1.58719494
32	MP0008872_abnormal_physiological_respon	1.58355030
33	MP0004043_abnormal_pH_regulation	1.55838815
34	MP0002733_abnormal_thermal_nociception	1.54144352
35	MP0005367_renal/urinary_system_phenotyp	1.53758643
36	MP0000516_abnormal_urinary_system	1.53758643
37	MP0002734_abnormal_mechanical_nocicepti	1.53556874
38	MP0000631_abnormal_neuroendocrine_gland	1.53374943
39	MP0001501_abnormal_sleep_pattern	1.52451257
40	MP0004145_abnormal_muscle_electrophysio	1.47951622
41	MP0002572_abnormal_emotion/affect_behav	1.47943968
42	MP0001485_abnormal_pinna_reflex	1.42335136
43	MP0002837_dystrophic_cardiac_calcinosis	1.41869880
44	MP0002938_white_spotting	1.40070153
45	MP0000647_abnormal_sebaceous_gland	1.40065937
46	MP0004142_abnormal_muscle_tone	1.39395629
47	MP0001986_abnormal_taste_sensitivity	1.38727417
48	MP0004133_heterotaxia	1.36862321
49	MP0002064_seizures	1.36677319
50	MP0002557_abnormal_social/conspecific_i	1.32480938
51	MP0008995_early_reproductive_senescence	1.30539919
52	MP0003635_abnormal_synaptic_transmissio	1.30488207
53	MP0001529_abnormal_vocalization	1.23652071
54	MP0002063_abnormal_learning/memory/cond	1.20807196
55	MP0002751_abnormal_autonomic_nervous	1.18573886
56	MP0002067_abnormal_sensory_capabilities	1.17500140
57	MP0004742_abnormal_vestibular_system	1.13877963
58	MP0002653_abnormal_ependyma_morphology	1.11773366
59	MP0003787_abnormal_imprinting	1.10850113
60	MP0006292_abnormal_olfactory_placode	1.10233384
61	MP0005410_abnormal_fertilization	1.08511657
62	MP0001919_abnormal_reproductive_system	1.04771940
63	MP0005389_reproductive_system_phenotype	1.04648556
64	MP0001905_abnormal_dopamine_level	1.03986225
65	MP0005195_abnormal_posterior_eye	1.01887033
66	MP0005075_abnormal_melanosome_morpholog	1.01583752
67	MP0003646_muscle_fatigue	0.99896939
68	MP0002095_abnormal_skin_pigmentation	0.99637875
69	MP0003136_yellow_coat_color	0.97948071
70	MP0000778_abnormal_nervous_system	0.97728605
71	MP0001764_abnormal_homeostasis	0.96836422
72	MP0002234_abnormal_pharynx_morphology	0.95154914
73	MP0002752_abnormal_somatic_nervous	0.95123530
74	MP0000383_abnormal_hair_follicle	0.95058793
75	MP0002909_abnormal_adrenal_gland	0.94675184
76	MP0005171_absent_coat_pigmentation	0.94176494
77	MP0002160_abnormal_reproductive_system	0.93719456
78	MP0005167_abnormal_blood-brain_barrier	0.93398899
79	MP0008789_abnormal_olfactory_epithelium	0.91600969
80	MP0002693_abnormal_pancreas_physiology	0.89958789
81	MP0002184_abnormal_innervation	0.89367753
82	MP0002163_abnormal_gland_morphology	0.86677004
83	MP0005174_abnormal_tail_pigmentation	0.86534895
84	MP0004924_abnormal_behavior	0.85541841
85	MP0005386_behavior/neurological_phenoty	0.85541841
86	MP0001963_abnormal_hearing_physiology	0.85514933
87	MP0000230_abnormal_systemic_arterial	0.82625434
88	MP0003698_abnormal_male_reproductive	0.82458145
89	MP0010329_abnormal_lipoprotein_level	0.82033565
90	MP0002229_neurodegeneration	0.81649512
91	MP0000026_abnormal_inner_ear	0.81419976
92	MP0003137_abnormal_impulse_conducting	0.80236538
93	MP0003121_genomic_imprinting	0.79173167
94	MP0005220_abnormal_exocrine_pancreas	0.77599039
95	MP0003718_maternal_effect	0.76382333
96	MP0002928_abnormal_bile_duct	0.76378574
97	MP0002882_abnormal_neuron_morphology	0.75812631
98	MP0004215_abnormal_myocardial_fiber	0.73996755
99	MP0003786_premature_aging	0.70901032
100	MP0002210_abnormal_sex_determination	0.70796096

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.20189803
2	True hermaphroditism (HP:0010459)	4.14224206
3	Pancreatic fibrosis (HP:0100732)	4.13746796
4	Abnormality of midbrain morphology (HP:0002418)	4.09877497
5	Molar tooth sign on MRI (HP:0002419)	4.09877497
6	Congenital stationary night blindness (HP:0007642)	3.82673529
7	Nephronophthisis (HP:0000090)	3.77609585
8	Medial flaring of the eyebrow (HP:0010747)	3.48586103
9	Abnormality of the renal medulla (HP:0100957)	3.18322569
10	Abnormality of the renal cortex (HP:0011035)	3.02820780
11	Hyperventilation (HP:0002883)	2.86653740
12	Abolished electroretinogram (ERG) (HP:0000550)	2.83306282
13	Gait imbalance (HP:0002141)	2.81901731
14	Congenital primary aphakia (HP:0007707)	2.80591218
15	Febrile seizures (HP:0002373)	2.65868707
16	3-Methylglutaconic aciduria (HP:0003535)	2.63486715
17	Cystic liver disease (HP:0006706)	2.62009176
18	Progressive cerebellar ataxia (HP:0002073)	2.60878627
19	Nephrogenic diabetes insipidus (HP:0009806)	2.59589028
20	Inability to walk (HP:0002540)	2.59126574
21	Chronic hepatic failure (HP:0100626)	2.58076562
22	Type II lissencephaly (HP:0007260)	2.57645496
23	Abnormal rod and cone electroretinograms (HP:0008323)	2.56468756
24	Attenuation of retinal blood vessels (HP:0007843)	2.55918334
25	Genital tract atresia (HP:0001827)	2.55555123
26	Ketoacidosis (HP:0001993)	2.54815909
27	Abnormal drinking behavior (HP:0030082)	2.52797917
28	Polydipsia (HP:0001959)	2.52797917
29	Congenital, generalized hypertrichosis (HP:0004540)	2.52242743
30	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.51931677
31	Hypothermia (HP:0002045)	2.38585293
32	Fair hair (HP:0002286)	2.38192826
33	Gaze-evoked nystagmus (HP:0000640)	2.35795533
34	Sclerocornea (HP:0000647)	2.31402844
35	Renal cortical cysts (HP:0000803)	2.31148537
36	Vaginal atresia (HP:0000148)	2.30322092
37	Focal motor seizures (HP:0011153)	2.29888812
38	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.29566540
39	Congenital hepatic fibrosis (HP:0002612)	2.27125682
40	Tubular atrophy (HP:0000092)	2.26375925
41	Hemiparesis (HP:0001269)	2.24404229
42	Mitochondrial inheritance (HP:0001427)	2.21288794
43	Anencephaly (HP:0002323)	2.20422243
44	Decreased circulating renin level (HP:0003351)	2.19073311
45	Lissencephaly (HP:0001339)	2.18684061
46	Male pseudohermaphroditism (HP:0000037)	2.18540175
47	Increased CSF lactate (HP:0002490)	2.17640741
48	Congenital sensorineural hearing impairment (HP:0008527)	2.16352615
49	Acute necrotizing encephalopathy (HP:0006965)	2.16161090
50	Absent speech (HP:0001344)	2.15981155
51	Severe muscular hypotonia (HP:0006829)	2.13320871
52	Bile duct proliferation (HP:0001408)	2.11517228
53	Abnormal biliary tract physiology (HP:0012439)	2.11517228
54	Progressive inability to walk (HP:0002505)	2.11254629
55	Large for gestational age (HP:0001520)	2.09895742
56	Furrowed tongue (HP:0000221)	2.09749599
57	Increased corneal curvature (HP:0100692)	2.08450577
58	Keratoconus (HP:0000563)	2.08450577
59	Focal seizures (HP:0007359)	2.07390475
60	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.06919689
61	Dialeptic seizures (HP:0011146)	2.06603862
62	Retinal dysplasia (HP:0007973)	2.06075598
63	Abnormality of macular pigmentation (HP:0008002)	2.05750686
64	Poor coordination (HP:0002370)	2.03510772
65	Pachygyria (HP:0001302)	2.02676925
66	Ketosis (HP:0001946)	2.02571858
67	Postaxial foot polydactyly (HP:0001830)	2.00381231
68	Hyperglycinuria (HP:0003108)	1.99862830
69	Progressive macrocephaly (HP:0004481)	1.99511673
70	Postaxial hand polydactyly (HP:0001162)	1.98969858
71	Thyroid-stimulating hormone excess (HP:0002925)	1.98585768
72	Decreased central vision (HP:0007663)	1.98076192
73	Acute encephalopathy (HP:0006846)	1.97713725
74	Polyuria (HP:0000103)	1.97608380
75	Short tibia (HP:0005736)	1.97345287
76	Cerebellar dysplasia (HP:0007033)	1.92716256
77	Thyroiditis (HP:0100646)	1.91544187
78	Bony spicule pigmentary retinopathy (HP:0007737)	1.91235353
79	Pendular nystagmus (HP:0012043)	1.90726011
80	Absent/shortened dynein arms (HP:0200106)	1.86288584
81	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.86288584
82	Constricted visual fields (HP:0001133)	1.84625192
83	Generalized hypopigmentation of hair (HP:0011358)	1.82910739
84	Hypoproteinemia (HP:0003075)	1.82754973
85	Hepatic necrosis (HP:0002605)	1.80646509
86	Optic disc pallor (HP:0000543)	1.79693147
87	Broad-based gait (HP:0002136)	1.78535822
88	Optic nerve hypoplasia (HP:0000609)	1.77893845
89	Abnormality of alanine metabolism (HP:0010916)	1.76139468
90	Hyperalaninemia (HP:0003348)	1.76139468
91	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.76139468
92	Hepatocellular necrosis (HP:0001404)	1.75242608
93	Retinitis pigmentosa (HP:0000510)	1.75067825
94	Narrow forehead (HP:0000341)	1.75055809
95	Neonatal respiratory distress (HP:0002643)	1.74750050
96	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.73878864
97	Abnormal respiratory motile cilium morphology (HP:0005938)	1.73663512
98	Abnormal respiratory epithelium morphology (HP:0012253)	1.73663512
99	Widely spaced teeth (HP:0000687)	1.73513391
100	Abnormal mitochondria in muscle tissue (HP:0008316)	1.71642061

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.32767603
2	BMPR1B	4.21621552
3	MAP4K2	3.57132237
4	ADRBK2	2.82319684
5	CASK	2.74996917
6	TRIM28	2.71878565
7	WNK3	2.69333036
8	MUSK	2.22621721
9	PINK1	2.20670282
10	TAOK3	2.14208332
11	INSRR	2.06131586
12	GRK1	1.99584818
13	CDK8	1.85279302
14	MAP3K4	1.84308139
15	MAPK13	1.65195591
16	NTRK3	1.63519167
17	VRK1	1.63494522
18	ZAK	1.60271265
19	ACVR1B	1.55750044
20	EPHA4	1.50724050
21	OXSR1	1.49680144
22	TGFBR1	1.48717018
23	EPHA3	1.48091178
24	TLK1	1.47784276
25	MAP2K6	1.47027779
26	BCR	1.39217222
27	MARK1	1.38755100
28	NUAK1	1.30293767
29	MKNK2	1.24866332
30	PRKCE	1.24105852
31	MAP2K7	1.22944592
32	CDK19	1.22412499
33	ERBB3	1.20833256
34	CAMKK2	1.15969178
35	TXK	1.15270548
36	PLK2	1.12083869
37	WNK4	1.09420966
38	STK38L	1.07397075
39	PAK3	1.06746210
40	TNIK	1.03207836
41	DAPK2	1.02912950
42	PNCK	1.02694675
43	PHKG1	0.99838268
44	PHKG2	0.99838268
45	NLK	0.94617574
46	CSNK1G2	0.93893675
47	CSNK1G1	0.93538637
48	PTK2B	0.92613559
49	BCKDK	0.92542430
50	PRKCG	0.89001283
51	ADRBK1	0.87740532
52	CSNK1G3	0.84082985
53	MAPKAPK3	0.78921819
54	STK16	0.77556922
55	MKNK1	0.76471885
56	PLK3	0.74965810
57	STK39	0.70572305
58	DYRK1A	0.70012566
59	EIF2AK3	0.69611325
60	CSNK1A1L	0.67790708
61	FGFR2	0.65430009
62	STK3	0.65146455
63	DYRK2	0.64673012
64	TAF1	0.62330935
65	TEC	0.59910054
66	MST4	0.58769948
67	IRAK1	0.56793717
68	FER	0.56426396
69	CAMK2A	0.55242290
70	PIK3CA	0.51168726
71	PKN1	0.48114564
72	PRKACA	0.42214310
73	CSNK1A1	0.39697701
74	TSSK6	0.39152540
75	FES	0.38997094
76	ITK	0.38185347
77	PRKCQ	0.37026155
78	CAMK1	0.36907240
79	RPS6KA5	0.36906375
80	STK24	0.35149476
81	CSNK1D	0.33136330
82	ERBB2	0.33022402
83	NME1	0.32438510
84	MATK	0.31506972
85	PRKCA	0.31274494
86	MAPKAPK5	0.30916573
87	MAPK15	0.30668438
88	RPS6KA4	0.29664689
89	ATM	0.28535021
90	IKBKB	0.28465939
91	TIE1	0.27601966
92	CAMK1G	0.26951674
93	PRKAA1	0.26081759
94	IGF1R	0.25608736
95	PRKG1	0.24935453
96	ABL1	0.23700681
97	DAPK1	0.23445298
98	MINK1	0.22851160
99	TNK2	0.22559729
100	STK11	0.22211493

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.99633411
2	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.86070518
3	Butanoate metabolism_Homo sapiens_hsa00650	2.81168668
4	Linoleic acid metabolism_Homo sapiens_hsa00591	2.77455139
5	Nitrogen metabolism_Homo sapiens_hsa00910	2.45172117
6	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.43135080
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.38831532
8	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.27936929
9	Selenocompound metabolism_Homo sapiens_hsa00450	2.24267719
10	Phototransduction_Homo sapiens_hsa04744	2.20940729
11	Ether lipid metabolism_Homo sapiens_hsa00565	2.12580947
12	Protein export_Homo sapiens_hsa03060	2.01129024
13	Nicotine addiction_Homo sapiens_hsa05033	2.00936534
14	Oxidative phosphorylation_Homo sapiens_hsa00190	2.00093354
15	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.90794978
16	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.88089919
17	Taste transduction_Homo sapiens_hsa04742	1.84158982
18	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.78293917
19	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.64227621
20	Propanoate metabolism_Homo sapiens_hsa00640	1.64091273
21	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.56214971
22	Morphine addiction_Homo sapiens_hsa05032	1.50686935
23	Basal transcription factors_Homo sapiens_hsa03022	1.49899354
24	Parkinsons disease_Homo sapiens_hsa05012	1.45648498
25	Homologous recombination_Homo sapiens_hsa03440	1.39475785
26	GABAergic synapse_Homo sapiens_hsa04727	1.31715148
27	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.30791926
28	Tryptophan metabolism_Homo sapiens_hsa00380	1.26979977
29	Collecting duct acid secretion_Homo sapiens_hsa04966	1.25804750
30	Asthma_Homo sapiens_hsa05310	1.25477652
31	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.24439907
32	Fanconi anemia pathway_Homo sapiens_hsa03460	1.20051108
33	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.17980031
34	Olfactory transduction_Homo sapiens_hsa04740	1.16091417
35	Insulin secretion_Homo sapiens_hsa04911	1.15190250
36	RNA polymerase_Homo sapiens_hsa03020	1.15154210
37	Glutamatergic synapse_Homo sapiens_hsa04724	1.14054444
38	Caffeine metabolism_Homo sapiens_hsa00232	1.13478783
39	Peroxisome_Homo sapiens_hsa04146	1.12724969
40	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.12621807
41	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.12005778
42	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.09554993
43	Serotonergic synapse_Homo sapiens_hsa04726	1.07339041
44	Regulation of autophagy_Homo sapiens_hsa04140	1.05103860
45	Chemical carcinogenesis_Homo sapiens_hsa05204	1.05080038
46	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.04715609
47	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.04464588
48	Sulfur metabolism_Homo sapiens_hsa00920	1.04336616
49	One carbon pool by folate_Homo sapiens_hsa00670	1.04270137
50	Type I diabetes mellitus_Homo sapiens_hsa04940	1.02149345
51	Circadian entrainment_Homo sapiens_hsa04713	1.00095230
52	Proteasome_Homo sapiens_hsa03050	0.99572012
53	ABC transporters_Homo sapiens_hsa02010	0.99446354
54	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.95400652
55	Retinol metabolism_Homo sapiens_hsa00830	0.94480558
56	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.93620988
57	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.92246273
58	Huntingtons disease_Homo sapiens_hsa05016	0.85810734
59	Alzheimers disease_Homo sapiens_hsa05010	0.83634034
60	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.82053528
61	Fat digestion and absorption_Homo sapiens_hsa04975	0.77483932
62	RNA degradation_Homo sapiens_hsa03018	0.76177623
63	Graft-versus-host disease_Homo sapiens_hsa05332	0.76066379
64	Salivary secretion_Homo sapiens_hsa04970	0.75667733
65	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.75160780
66	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.74639114
67	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.70208435
68	Non-homologous end-joining_Homo sapiens_hsa03450	0.69320759
69	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.68151330
70	Calcium signaling pathway_Homo sapiens_hsa04020	0.67373398
71	Long-term depression_Homo sapiens_hsa04730	0.67052864
72	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.65629383
73	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.65233703
74	Dopaminergic synapse_Homo sapiens_hsa04728	0.64482222
75	Allograft rejection_Homo sapiens_hsa05330	0.64397806
76	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.64187912
77	Glycerolipid metabolism_Homo sapiens_hsa00561	0.63815490
78	Cocaine addiction_Homo sapiens_hsa05030	0.59243966
79	Metabolic pathways_Homo sapiens_hsa01100	0.57688108
80	beta-Alanine metabolism_Homo sapiens_hsa00410	0.57543507
81	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.56674332
82	Cardiac muscle contraction_Homo sapiens_hsa04260	0.55431358
83	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.51632233
84	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.51050892
85	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.50422870
86	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.47177896
87	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.46953228
88	Purine metabolism_Homo sapiens_hsa00230	0.45658419
89	Amphetamine addiction_Homo sapiens_hsa05031	0.43800261
90	Rheumatoid arthritis_Homo sapiens_hsa05323	0.41822066
91	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.41384827
92	Primary immunodeficiency_Homo sapiens_hsa05340	0.39412292
93	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.37576313
94	Cholinergic synapse_Homo sapiens_hsa04725	0.37167530
95	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.36270015
96	cAMP signaling pathway_Homo sapiens_hsa04024	0.34649183
97	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.33393006
98	Fatty acid metabolism_Homo sapiens_hsa01212	0.32639940
99	Steroid biosynthesis_Homo sapiens_hsa00100	0.32534519
100	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.31950955

PRORY

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »