PROS2P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cysteine metabolic process (GO:0006534)5.73549499
2protein neddylation (GO:0045116)5.57942625
3negative regulation of cAMP-mediated signaling (GO:0043951)5.50498004
4artery smooth muscle contraction (GO:0014824)5.49890687
5leukotriene biosynthetic process (GO:0019370)5.06495772
6behavioral response to ethanol (GO:0048149)5.01743053
7tonic smooth muscle contraction (GO:0014820)4.99109876
8negative regulation of appetite (GO:0032099)4.88953761
9negative regulation of response to food (GO:0032096)4.88953761
10response to gravity (GO:0009629)4.87794044
11mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.81938515
12regulation of cilium movement (GO:0003352)4.69086751
13viral transcription (GO:0019083)4.61151620
14negative regulation of cytosolic calcium ion concentration (GO:0051481)4.55781037
15behavioral response to cocaine (GO:0048148)4.49088015
16translational termination (GO:0006415)4.43435822
17ATP synthesis coupled proton transport (GO:0015986)4.37875512
18energy coupled proton transport, down electrochemical gradient (GO:0015985)4.37875512
19negative regulation of nitric oxide biosynthetic process (GO:0045019)4.35978135
20opioid receptor signaling pathway (GO:0038003)4.33968231
21vascular smooth muscle contraction (GO:0014829)4.14500750
22serine family amino acid biosynthetic process (GO:0009070)4.13298836
23nonmotile primary cilium assembly (GO:0035058)4.05481827
24cotranslational protein targeting to membrane (GO:0006613)4.03065288
25SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.00763833
26regulation of appetite (GO:0032098)3.99988556
27adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.94539455
28positive regulation of cAMP-mediated signaling (GO:0043950)3.93340924
29pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)3.92058339
30UMP metabolic process (GO:0046049)3.92058339
31pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)3.92058339
32UMP biosynthetic process (GO:0006222)3.92058339
33protein targeting to ER (GO:0045047)3.91414642
34protein localization to endoplasmic reticulum (GO:0070972)3.82285606
35termination of RNA polymerase III transcription (GO:0006386)3.78004078
36transcription elongation from RNA polymerase III promoter (GO:0006385)3.78004078
37establishment of protein localization to endoplasmic reticulum (GO:0072599)3.76690237
38translational elongation (GO:0006414)3.75068664
39pyrimidine nucleoside monophosphate metabolic process (GO:0009129)3.71987462
40nucleotide transmembrane transport (GO:1901679)3.64429634
41striatum development (GO:0021756)3.63804619
42positive regulation of endothelial cell differentiation (GO:0045603)3.62826883
43regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.62324197
44cellular response to leptin stimulus (GO:0044320)3.60972771
45negative regulation of amino acid transport (GO:0051956)3.56095893
46ribosomal large subunit biogenesis (GO:0042273)3.52484784
47cardiac left ventricle morphogenesis (GO:0003214)3.48773377
48detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.44829617
49negative regulation of synaptic transmission, GABAergic (GO:0032229)3.40618220
50fatty acid derivative biosynthetic process (GO:1901570)3.39259037
51icosanoid biosynthetic process (GO:0046456)3.39259037
52leukotriene metabolic process (GO:0006691)3.37496504
53somite rostral/caudal axis specification (GO:0032525)3.36251413
54pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)3.36041321
55protein complex biogenesis (GO:0070271)3.35880601
56regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.23564729
57regulation of response to food (GO:0032095)3.23465799
58SMAD protein complex assembly (GO:0007183)3.22844687
59cellular protein complex disassembly (GO:0043624)3.22759769
60ether lipid metabolic process (GO:0046485)3.21016087
61sequestering of actin monomers (GO:0042989)3.20851355
62pyrimidine nucleoside biosynthetic process (GO:0046134)3.20153985
63mitochondrial respiratory chain complex assembly (GO:0033108)3.18881401
64protein localization to synapse (GO:0035418)3.18550606
65transmission of nerve impulse (GO:0019226)3.11496020
66melanosome transport (GO:0032402)3.11459315
67brain morphogenesis (GO:0048854)3.08002208
68prenylation (GO:0097354)3.07758667
69protein prenylation (GO:0018342)3.07758667
70sensory perception of smell (GO:0007608)3.07726401
71viral life cycle (GO:0019058)3.06367845
72regulation of endothelial cell differentiation (GO:0045601)3.06164400
73sulfur amino acid biosynthetic process (GO:0000097)3.02451548
74establishment of melanosome localization (GO:0032401)3.00614802
75regulation of glutamate secretion (GO:0014048)2.94674318
76negative regulation of calcium ion transport into cytosol (GO:0010523)2.94104149
77negative regulation of membrane potential (GO:0045837)2.93920262
78nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.93172919
79skeletal muscle tissue regeneration (GO:0043403)2.92707448
80melanosome localization (GO:0032400)2.91278418
81pyrimidine-containing compound biosynthetic process (GO:0072528)2.90826353
82pigment granule transport (GO:0051904)2.89862009
83regulation of chromatin binding (GO:0035561)2.89390979
84response to leptin (GO:0044321)2.87409856
85pyrimidine ribonucleoside biosynthetic process (GO:0046132)2.84335782
86folic acid-containing compound biosynthetic process (GO:0009396)2.82959863
87protein localization to cilium (GO:0061512)2.81230930
88establishment of pigment granule localization (GO:0051905)2.80428011
89embryonic skeletal joint morphogenesis (GO:0060272)2.80053246
90regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.79747988
91NADH dehydrogenase complex assembly (GO:0010257)2.78949505
92mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.78949505
93mitochondrial respiratory chain complex I assembly (GO:0032981)2.78949505
94cellular glucuronidation (GO:0052695)2.78159065
95convergent extension (GO:0060026)2.73673958
96pigment granule localization (GO:0051875)2.73080025
97regulation of glutamate receptor signaling pathway (GO:1900449)2.72514082
98nucleoside transmembrane transport (GO:1901642)2.68339027
99protein targeting to membrane (GO:0006612)2.68192554
100regulation of skeletal muscle contraction (GO:0014819)2.67841958

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human4.49070734
2EZH2_22144423_ChIP-Seq_EOC_Human3.47746298
3TAF15_26573619_Chip-Seq_HEK293_Human3.19593043
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.00210761
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.94338233
6IGF1R_20145208_ChIP-Seq_DFB_Human2.68885475
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.57092296
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.48125814
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.37633995
10CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.33523616
11FUS_26573619_Chip-Seq_HEK293_Human2.22297239
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.09811972
13RNF2_27304074_Chip-Seq_NSC_Mouse2.09264939
14P300_19829295_ChIP-Seq_ESCs_Human2.08261921
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.08090896
16EGR1_19032775_ChIP-ChIP_M12_Human2.07663197
17ZNF274_21170338_ChIP-Seq_K562_Hela2.03535457
18POU5F1_16153702_ChIP-ChIP_HESCs_Human2.02344828
19PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.00619876
20GABP_17652178_ChIP-ChIP_JURKAT_Human1.98974421
21ZFP57_27257070_Chip-Seq_ESCs_Mouse1.97163297
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.93905810
23ELK1_19687146_ChIP-ChIP_HELA_Human1.87237930
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.86092276
25IRF1_19129219_ChIP-ChIP_H3396_Human1.83925813
26TRIM28_21343339_ChIP-Seq_HEK293_Human1.81898672
27EWS_26573619_Chip-Seq_HEK293_Human1.77538954
28KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.76148940
29MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.68073811
30BCAT_22108803_ChIP-Seq_LS180_Human1.67279169
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.65844849
32ER_23166858_ChIP-Seq_MCF-7_Human1.65818683
33RBPJ_22232070_ChIP-Seq_NCS_Mouse1.65442596
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.63642979
35MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.58260255
36BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.57846417
37PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.57275224
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.55436938
39EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.52464942
40RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.49635560
41ZNF263_19887448_ChIP-Seq_K562_Human1.47699045
42EST1_17652178_ChIP-ChIP_JURKAT_Human1.45324559
43KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.44035483
44KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.44035483
45KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.44035483
46GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.42702287
47BMI1_23680149_ChIP-Seq_NPCS_Mouse1.42414417
48JARID2_20064375_ChIP-Seq_MESCs_Mouse1.38716077
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.38407646
50IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36929235
51CBP_20019798_ChIP-Seq_JUKART_Human1.36929235
52TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36779425
53EED_16625203_ChIP-ChIP_MESCs_Mouse1.36414543
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35957014
55HIF1A_21447827_ChIP-Seq_MCF-7_Human1.34254181
56CDX2_19796622_ChIP-Seq_MESCs_Mouse1.33751283
57SMAD4_21799915_ChIP-Seq_A2780_Human1.33174723
58AR_20517297_ChIP-Seq_VCAP_Human1.30065091
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.28901788
60RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.28217812
61TP53_18474530_ChIP-ChIP_U2OS_Human1.28149056
62TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.28014397
63STAT1_20625510_ChIP-Seq_HELA_Human1.24715761
64NANOG_19829295_ChIP-Seq_ESCs_Human1.23550819
65SOX2_19829295_ChIP-Seq_ESCs_Human1.23550819
66SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.22907103
67SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22080615
68UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21138958
69CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.19543572
70SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.18183862
71EZH2_27304074_Chip-Seq_ESCs_Mouse1.17656486
72RXR_22108803_ChIP-Seq_LS180_Human1.17524910
73SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.16907209
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16644503
75SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.15440595
76CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15390583
77AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15346490
78NANOG_16153702_ChIP-ChIP_HESCs_Human1.15101666
79GBX2_23144817_ChIP-Seq_PC3_Human1.14786569
80NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.13389075
81NRF2_20460467_ChIP-Seq_MEFs_Mouse1.13389075
82NOTCH1_21737748_ChIP-Seq_TLL_Human1.09645269
83EZH2_18974828_ChIP-Seq_MESCs_Mouse1.08199550
84RNF2_18974828_ChIP-Seq_MESCs_Mouse1.08199550
85NANOG_18555785_Chip-Seq_ESCs_Mouse1.08103917
86TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06780965
87CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.06098270
88HTT_18923047_ChIP-ChIP_STHdh_Human1.06008445
89NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04108948
90TCF4_22108803_ChIP-Seq_LS180_Human1.04076390
91TCF4_23295773_ChIP-Seq_U87_Human1.04046250
92SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.03286261
93FOXA1_25329375_ChIP-Seq_VCAP_Human1.01274178
94FOXA1_27270436_Chip-Seq_PROSTATE_Human1.01274178
95CDX2_22108803_ChIP-Seq_LS180_Human1.01052471
96ARNT_22903824_ChIP-Seq_MCF-7_Human0.99165969
97SOX2_16153702_ChIP-ChIP_HESCs_Human0.97833614
98LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97075374
99TP53_22573176_ChIP-Seq_HFKS_Human0.96633216
100JARID2_20075857_ChIP-Seq_MESCs_Mouse0.95451200

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005499_abnormal_olfactory_system5.02234898
2MP0005394_taste/olfaction_phenotype5.02234898
3MP0008789_abnormal_olfactory_epithelium4.97757045
4MP0001968_abnormal_touch/_nociception4.04696906
5MP0001529_abnormal_vocalization3.84358645
6MP0001984_abnormal_olfaction3.66195347
7MP0009379_abnormal_foot_pigmentation3.16505207
8MP0002736_abnormal_nociception_after2.78919682
9MP0008775_abnormal_heart_ventricle2.69425918
10MP0005257_abnormal_intraocular_pressure2.59459949
11MP0003011_delayed_dark_adaptation2.53031080
12MP0003890_abnormal_embryonic-extraembry2.37284736
13MP0005670_abnormal_white_adipose2.32263025
14MP0005645_abnormal_hypothalamus_physiol2.17716906
15MP0003959_abnormal_lean_body2.14029270
16MP0002163_abnormal_gland_morphology2.09144974
17MP0006276_abnormal_autonomic_nervous1.93303352
18MP0001764_abnormal_homeostasis1.92308965
19MP0009278_abnormal_bone_marrow1.87756282
20MP0002233_abnormal_nose_morphology1.66569128
21MP0003880_abnormal_central_pattern1.60271260
22MP0002089_abnormal_postnatal_growth/wei1.53649114
23MP0002822_catalepsy1.46072723
24MP0004145_abnormal_muscle_electrophysio1.43799037
25MP0003183_abnormal_peptide_metabolism1.42339575
26MP0009697_abnormal_copulation1.37378056
27MP0003646_muscle_fatigue1.35245510
28MP0002160_abnormal_reproductive_system1.35210214
29MP0005167_abnormal_blood-brain_barrier1.34250516
30MP0000230_abnormal_systemic_arterial1.32250105
31MP0010030_abnormal_orbit_morphology1.31260125
32MP0005195_abnormal_posterior_eye1.28870786
33MP0001485_abnormal_pinna_reflex1.27857182
34MP0002837_dystrophic_cardiac_calcinosis1.27711942
35MP0005084_abnormal_gallbladder_morpholo1.22872205
36MP0002735_abnormal_chemical_nociception1.22691929
37MP0005551_abnormal_eye_electrophysiolog1.19685342
38MP0003638_abnormal_response/metabolism_1.19345004
39MP0000631_abnormal_neuroendocrine_gland1.17967173
40MP0003937_abnormal_limbs/digits/tail_de1.17713616
41MP0002932_abnormal_joint_morphology1.16046421
42MP0005646_abnormal_pituitary_gland1.13113968
43MP0003633_abnormal_nervous_system1.09527001
44MP0002090_abnormal_vision1.09396444
45MP0003119_abnormal_digestive_system1.06362729
46MP0008995_early_reproductive_senescence1.06273381
47MP0005253_abnormal_eye_physiology1.03884699
48MP0004484_altered_response_of1.01913507
49MP0002733_abnormal_thermal_nociception1.00755614
50MP0008004_abnormal_stomach_pH0.97357367
51MP0005408_hypopigmentation0.95351038
52MP0003195_calcinosis0.93076076
53MP0008872_abnormal_physiological_respon0.91669340
54MP0002752_abnormal_somatic_nervous0.90753640
55MP0005187_abnormal_penis_morphology0.90219034
56MP0001542_abnormal_bone_strength0.87323147
57MP0005503_abnormal_tendon_morphology0.85787426
58MP0000049_abnormal_middle_ear0.85782766
59MP0001905_abnormal_dopamine_level0.85775903
60MP0002697_abnormal_eye_size0.85368096
61MP0001501_abnormal_sleep_pattern0.84818015
62MP0004147_increased_porphyrin_level0.84259630
63MP0009764_decreased_sensitivity_to0.84184433
64MP0005360_urolithiasis0.82933367
65MP0001545_abnormal_hematopoietic_system0.81966427
66MP0005397_hematopoietic_system_phenotyp0.81966427
67MP0004142_abnormal_muscle_tone0.81603678
68MP0002132_abnormal_respiratory_system0.80408521
69MP0002109_abnormal_limb_morphology0.78906430
70MP0001340_abnormal_eyelid_morphology0.78614591
71MP0003631_nervous_system_phenotype0.76036955
72MP0001664_abnormal_digestion0.74903236
73MP0005410_abnormal_fertilization0.74668411
74MP0005334_abnormal_fat_pad0.71560760
75MP0001879_abnormal_lymphatic_vessel0.70410788
76MP0003878_abnormal_ear_physiology0.69881729
77MP0005377_hearing/vestibular/ear_phenot0.69881729
78MP0005376_homeostasis/metabolism_phenot0.69749761
79MP0005647_abnormal_sex_gland0.69341088
80MP0005448_abnormal_energy_balance0.68819802
81MP0000750_abnormal_muscle_regeneration0.68009816
82MP0001286_abnormal_eye_development0.67516988
83MP0002234_abnormal_pharynx_morphology0.67471247
84MP0000343_altered_response_to0.66940013
85MP0001661_extended_life_span0.65957910
86MP0009250_abnormal_appendicular_skeleto0.65900248
87MP0005379_endocrine/exocrine_gland_phen0.65688486
88MP0010771_integument_phenotype0.65259746
89MP0005391_vision/eye_phenotype0.65029147
90MP0003786_premature_aging0.64785731
91MP0002272_abnormal_nervous_system0.64677990
92MP0000427_abnormal_hair_cycle0.64567893
93MP0006035_abnormal_mitochondrial_morpho0.64012011
94MP0005464_abnormal_platelet_physiology0.63801212
95MP0003136_yellow_coat_color0.61275333
96MP0005508_abnormal_skeleton_morphology0.59998625
97MP0003121_genomic_imprinting0.59882631
98MP0003567_abnormal_fetal_cardiomyocyte0.59696927
99MP0003123_paternal_imprinting0.58006234
100MP0002557_abnormal_social/conspecific_i0.57293324

Predicted human phenotypes

RankGene SetZ-score
1Abnormal pupillary function (HP:0007686)9.32870423
2Rectovaginal fistula (HP:0000143)5.41841585
3Rectal fistula (HP:0100590)5.41841585
4Cutaneous melanoma (HP:0012056)5.15835951
5Intestinal fistula (HP:0100819)4.53645518
6Vaginal fistula (HP:0004320)4.48375989
7Vitreoretinal degeneration (HP:0000655)4.29311214
8Palpebral edema (HP:0100540)3.72799242
9Adactyly (HP:0009776)3.63529740
10Hyperglycinemia (HP:0002154)3.50997043
11Medial flaring of the eyebrow (HP:0010747)3.34649842
12Congenital primary aphakia (HP:0007707)3.33747809
13Pendular nystagmus (HP:0012043)3.31077329
14Gait imbalance (HP:0002141)3.21036345
15Postaxial foot polydactyly (HP:0001830)3.13184717
16Attenuation of retinal blood vessels (HP:0007843)3.10671530
17Pancreatic fibrosis (HP:0100732)3.07871909
18Abnormal protein glycosylation (HP:0012346)3.05141547
19Abnormal glycosylation (HP:0012345)3.05141547
20Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.05141547
21Abnormal protein N-linked glycosylation (HP:0012347)3.05141547
22Nephrogenic diabetes insipidus (HP:0009806)2.96181200
23Septate vagina (HP:0001153)2.95694293
24Microretrognathia (HP:0000308)2.93265698
25Colon cancer (HP:0003003)2.86406754
26Abnormality of cells of the erythroid lineage (HP:0012130)2.85093320
27Bony spicule pigmentary retinopathy (HP:0007737)2.84815788
28Abolished electroretinogram (ERG) (HP:0000550)2.78389978
29Hydroureter (HP:0000072)2.77068020
30Poor coordination (HP:0002370)2.75650887
31Chorioretinal atrophy (HP:0000533)2.59903027
32Acute encephalopathy (HP:0006846)2.57758976
33Acute necrotizing encephalopathy (HP:0006965)2.54643302
34Congenital, generalized hypertrichosis (HP:0004540)2.49303676
35Optic disc pallor (HP:0000543)2.49211376
36Abnormality of the pupil (HP:0000615)2.48445066
37Scrotal hypoplasia (HP:0000046)2.47785137
38Chorioretinal coloboma (HP:0000567)2.44870756
39Genital tract atresia (HP:0001827)2.44545395
40Vaginal atresia (HP:0000148)2.44248533
41Hypoplastic left heart (HP:0004383)2.43920479
42Stenosis of the external auditory canal (HP:0000402)2.43913932
43Vertebral arch anomaly (HP:0008438)2.33314264
44Congenital hepatic fibrosis (HP:0002612)2.32756047
45Thyroid-stimulating hormone excess (HP:0002925)2.32310594
46Progressive macrocephaly (HP:0004481)2.30935356
47Absent rod-and cone-mediated responses on ERG (HP:0007688)2.29590078
48Abnormality of midbrain morphology (HP:0002418)2.23846347
49Molar tooth sign on MRI (HP:0002419)2.23846347
50Deformed tarsal bones (HP:0008119)2.22263479
51Entropion (HP:0000621)2.16941569
522-3 toe syndactyly (HP:0004691)2.16680742
53Calcaneovalgus deformity (HP:0001848)2.16026968
54Abnormal mitochondria in muscle tissue (HP:0008316)2.15138287
55Sparse eyelashes (HP:0000653)2.13647697
56Atresia of the external auditory canal (HP:0000413)2.11893996
57Partial duplication of thumb phalanx (HP:0009944)2.11870464
58Aplasia/Hypoplasia of the nipples (HP:0006709)2.11617001
59Conjunctival telangiectasia (HP:0000524)2.07301768
60Bifid tongue (HP:0010297)2.07109626
61Generalized aminoaciduria (HP:0002909)2.04572121
62Metaphyseal dysplasia (HP:0100255)2.03681285
63Increased corneal curvature (HP:0100692)2.02797576
64Keratoconus (HP:0000563)2.02797576
65Reticulocytopenia (HP:0001896)2.00200702
66Pancreatic cysts (HP:0001737)1.98227862
67Nausea (HP:0002018)1.97204225
68Mitochondrial inheritance (HP:0001427)1.96752427
69Thoracolumbar scoliosis (HP:0002944)1.95144663
70Left ventricular hypertrophy (HP:0001712)1.94338628
71Abnormality of DNA repair (HP:0003254)1.92715005
72Anencephaly (HP:0002323)1.92712195
73Partial duplication of the phalanx of hand (HP:0009999)1.91308996
743-Methylglutaconic aciduria (HP:0003535)1.91264977
75Beaking of vertebral bodies (HP:0004568)1.89415413
76Cupped ear (HP:0000378)1.87623264
77Abnormality of the phalanges of the 5th finger (HP:0004213)1.85700439
78Postnatal microcephaly (HP:0005484)1.85683439
79Hypoplastic heart (HP:0001961)1.84774439
80Limb dystonia (HP:0002451)1.84390904
81Meningioma (HP:0002858)1.82810560
82Abnormality of liposaccharide metabolism (HP:0010968)1.80335822
83Abnormality of glycosphingolipid metabolism (HP:0004343)1.80335822
84Abnormality of glycolipid metabolism (HP:0010969)1.80335822
85Poor head control (HP:0002421)1.79362125
86Adrenal hypoplasia (HP:0000835)1.79354855
87Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.78985802
88Aplasia/Hypoplasia of the tibia (HP:0005772)1.78608174
89True hermaphroditism (HP:0010459)1.76874087
90Specific learning disability (HP:0001328)1.76138214
91Primary adrenal insufficiency (HP:0008207)1.75160910
92Median cleft lip (HP:0000161)1.74935837
93Hyperkalemia (HP:0002153)1.74810456
94Hypoplastic iliac wings (HP:0002866)1.74755413
95Abnormality of the columella (HP:0009929)1.74383279
96Down-sloping shoulders (HP:0200021)1.73717628
97Short tibia (HP:0005736)1.73712848
98Optic nerve hypoplasia (HP:0000609)1.71292820
99Postaxial hand polydactyly (HP:0001162)1.70343386
100Renal cortical cysts (HP:0000803)1.69806056

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ADRBK24.43763033
2CASK4.36970434
3VRK24.15761131
4DYRK33.65080408
5PIK3CA3.51133905
6FRK3.48538668
7TAF13.08247133
8NUAK12.91144268
9CDC72.59776202
10BLK2.26933073
11NLK2.11451383
12TLK12.10211751
13TNIK1.86759820
14PIK3CG1.83096829
15MAP3K131.81567686
16STK38L1.80952980
17STK241.79146812
18DAPK11.78884333
19CSF1R1.61256506
20SCYL21.59928480
21DYRK21.57780542
22ADRBK11.57288812
23NME11.54767708
24MAP3K71.54193412
25MELK1.53648267
26VRK11.51213929
27FLT31.49708586
28NEK11.47116027
29CDK81.29409946
30PLK21.27271933
31PTK2B1.26933192
32DAPK21.22790834
33KIT1.21541480
34MAPKAPK51.20164323
35MKNK11.17833721
36GRK71.16295418
37TAOK31.14291287
38EPHA21.08513861
39EPHB21.05048214
40BMX1.04506088
41BMPR1B1.02933369
42TGFBR11.00079575
43GRK50.98206585
44STK30.97280355
45DYRK1A0.88070603
46DAPK30.87490917
47MST40.81934519
48OBSCN0.78951235
49CHUK0.76980155
50MATK0.76659786
51DYRK1B0.76219775
52MAP2K70.75910418
53PRKCG0.73197320
54CSNK1G20.73087380
55CSNK1G30.72380102
56CSNK1G10.67508458
57TYRO30.67087247
58PRKCE0.65835390
59MAP3K50.61732989
60ZAK0.61384453
61CSNK1A1L0.60790546
62TIE10.58104939
63FGFR10.57236973
64MAP3K60.56591530
65MAP2K40.55985373
66WNK40.55173616
67WNK30.53868866
68EPHA40.51191467
69FGFR20.50098135
70IKBKB0.48801275
71MAP3K90.48311283
72PLK30.47826754
73ACVR1B0.47530183
74MST1R0.46043763
75MAP2K30.44634156
76SIK10.44172077
77CAMK2A0.42756747
78STK110.41916809
79PASK0.40671990
80CDK90.37494830
81PLK40.37264130
82TRIM280.36365518
83CAMK2B0.35624477
84GRK10.34934188
85AURKB0.34926358
86ILK0.33636542
87CSNK2A20.33431813
88CCNB10.33182548
89MAP2K20.32957002
90INSRR0.30794114
91PLK10.30261494
92AKT20.29993836
93LRRK20.26796019
94PRKAA20.24868162
95LIMK10.23639355
96SYK0.23030862
97PHKG10.21766778
98PHKG20.21766778
99PRKCQ0.21674813
100PAK30.21503548

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006034.36854259
2Ribosome_Homo sapiens_hsa030104.31564245
3Folate biosynthesis_Homo sapiens_hsa007903.27363108
4Oxidative phosphorylation_Homo sapiens_hsa001902.96547540
5Sulfur relay system_Homo sapiens_hsa041222.85682170
6Protein export_Homo sapiens_hsa030602.77422189
7Parkinsons disease_Homo sapiens_hsa050122.50474076
8Nitrogen metabolism_Homo sapiens_hsa009102.30451834
9RNA polymerase_Homo sapiens_hsa030202.27763248
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.20962629
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.18011388
12One carbon pool by folate_Homo sapiens_hsa006702.12057502
13Huntingtons disease_Homo sapiens_hsa050162.11046601
14Steroid hormone biosynthesis_Homo sapiens_hsa001401.85171938
15Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.79164622
16Alzheimers disease_Homo sapiens_hsa050101.76776148
17Cysteine and methionine metabolism_Homo sapiens_hsa002701.73157999
18Basal transcription factors_Homo sapiens_hsa030221.67540973
19Glutathione metabolism_Homo sapiens_hsa004801.57129649
20Butanoate metabolism_Homo sapiens_hsa006501.56060653
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.53170602
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.43758740
23Arachidonic acid metabolism_Homo sapiens_hsa005901.41828667
24Cardiac muscle contraction_Homo sapiens_hsa042601.37986449
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.37627201
26Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.35408977
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.34224575
28Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.32305758
29Retinol metabolism_Homo sapiens_hsa008301.28318098
30Pentose and glucuronate interconversions_Homo sapiens_hsa000401.27726958
31Linoleic acid metabolism_Homo sapiens_hsa005911.19696299
32Basal cell carcinoma_Homo sapiens_hsa052171.19583969
33N-Glycan biosynthesis_Homo sapiens_hsa005101.18759914
34Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.18260141
35Morphine addiction_Homo sapiens_hsa050321.18135302
36Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.16336069
37Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.14270046
38Proteasome_Homo sapiens_hsa030501.13736437
39Nucleotide excision repair_Homo sapiens_hsa034201.07761439
40Collecting duct acid secretion_Homo sapiens_hsa049661.03484370
41Pyrimidine metabolism_Homo sapiens_hsa002401.03264222
42Pyruvate metabolism_Homo sapiens_hsa006201.03038756
43Chemical carcinogenesis_Homo sapiens_hsa052041.01679096
44Regulation of autophagy_Homo sapiens_hsa041400.96931973
45Purine metabolism_Homo sapiens_hsa002300.91836825
46Starch and sucrose metabolism_Homo sapiens_hsa005000.90963686
47Homologous recombination_Homo sapiens_hsa034400.90751843
48Serotonergic synapse_Homo sapiens_hsa047260.90537561
49Maturity onset diabetes of the young_Homo sapiens_hsa049500.87729644
50Drug metabolism - other enzymes_Homo sapiens_hsa009830.85214850
51Nicotine addiction_Homo sapiens_hsa050330.83801662
52SNARE interactions in vesicular transport_Homo sapiens_hsa041300.83741053
53Glutamatergic synapse_Homo sapiens_hsa047240.82040351
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81551938
55Hedgehog signaling pathway_Homo sapiens_hsa043400.81267041
56Olfactory transduction_Homo sapiens_hsa047400.79099221
57Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.77429740
58Taste transduction_Homo sapiens_hsa047420.76482928
59Circadian entrainment_Homo sapiens_hsa047130.74711229
60GABAergic synapse_Homo sapiens_hsa047270.74542744
61Salivary secretion_Homo sapiens_hsa049700.74397848
62Peroxisome_Homo sapiens_hsa041460.73353916
63Phototransduction_Homo sapiens_hsa047440.72132883
64Ovarian steroidogenesis_Homo sapiens_hsa049130.70972610
65Calcium signaling pathway_Homo sapiens_hsa040200.69892424
66Metabolic pathways_Homo sapiens_hsa011000.69697849
67Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.68114722
68TGF-beta signaling pathway_Homo sapiens_hsa043500.67841996
69Systemic lupus erythematosus_Homo sapiens_hsa053220.67161238
70RNA degradation_Homo sapiens_hsa030180.65498732
71Fat digestion and absorption_Homo sapiens_hsa049750.61089534
72Primary bile acid biosynthesis_Homo sapiens_hsa001200.60228776
73Mismatch repair_Homo sapiens_hsa034300.60140427
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.60018816
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56113132
76Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54544665
77Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.53282946
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52794361
79Hippo signaling pathway_Homo sapiens_hsa043900.52252171
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50642753
81Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.48681700
82Wnt signaling pathway_Homo sapiens_hsa043100.48066635
83Alcoholism_Homo sapiens_hsa050340.47301911
84Cyanoamino acid metabolism_Homo sapiens_hsa004600.44108819
85Glycerolipid metabolism_Homo sapiens_hsa005610.39864472
86Fatty acid elongation_Homo sapiens_hsa000620.36331101
87Fanconi anemia pathway_Homo sapiens_hsa034600.35599077
88Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.35064346
89Platelet activation_Homo sapiens_hsa046110.34226323
90Pentose phosphate pathway_Homo sapiens_hsa000300.33902756
91Mineral absorption_Homo sapiens_hsa049780.32789302
92Tryptophan metabolism_Homo sapiens_hsa003800.31146090
93Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.28349232
94Tight junction_Homo sapiens_hsa045300.23887408
95ECM-receptor interaction_Homo sapiens_hsa045120.22883596
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.21640087
97Renin secretion_Homo sapiens_hsa049240.21415962
98Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.19996371
99Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.18017999
100Sulfur metabolism_Homo sapiens_hsa009200.17878673

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