ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	L-phenylalanine catabolic process (GO:0006559)	6.42355657
2	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	6.42355657
3	L-phenylalanine metabolic process (GO:0006558)	6.11732805
4	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	6.11732805
5	aromatic amino acid family catabolic process (GO:0009074)	5.91825837
6	cysteine metabolic process (GO:0006534)	5.59347076
7	tryptophan catabolic process (GO:0006569)	5.47955335
8	indole-containing compound catabolic process (GO:0042436)	5.47955335
9	indolalkylamine catabolic process (GO:0046218)	5.47955335
10	tryptophan metabolic process (GO:0006568)	5.34688413
11	serine family amino acid catabolic process (GO:0009071)	5.15738708
12	lysine metabolic process (GO:0006553)	5.11460672
13	lysine catabolic process (GO:0006554)	5.11460672
14	kynurenine metabolic process (GO:0070189)	5.06023674
15	glyoxylate metabolic process (GO:0046487)	5.04080914
16	homocysteine metabolic process (GO:0050667)	4.85615356
17	drug transmembrane transport (GO:0006855)	4.78379409
18	urate metabolic process (GO:0046415)	4.63639186
19	aromatic amino acid family metabolic process (GO:0009072)	4.50776956
20	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	4.45351615
21	amino-acid betaine metabolic process (GO:0006577)	4.44766427
22	bile acid biosynthetic process (GO:0006699)	4.41497341
23	indolalkylamine metabolic process (GO:0006586)	4.29934905
24	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	4.27916695
25	protein carboxylation (GO:0018214)	4.21211664
26	peptidyl-glutamic acid carboxylation (GO:0017187)	4.21211664
27	alpha-amino acid catabolic process (GO:1901606)	4.19920847
28	serine family amino acid metabolic process (GO:0009069)	4.17755607
29	sulfur amino acid catabolic process (GO:0000098)	4.15242748
30	glutamate metabolic process (GO:0006536)	4.02548021
31	glycine metabolic process (GO:0006544)	4.02507006
32	cellular ketone body metabolic process (GO:0046950)	3.99581148
33	cellular biogenic amine catabolic process (GO:0042402)	3.98585128
34	amine catabolic process (GO:0009310)	3.98585128
35	valine metabolic process (GO:0006573)	3.97353554
36	2-oxoglutarate metabolic process (GO:0006103)	3.95799668
37	tyrosine metabolic process (GO:0006570)	3.95449207
38	urea cycle (GO:0000050)	3.93244291
39	urea metabolic process (GO:0019627)	3.93244291
40	cellular amino acid catabolic process (GO:0009063)	3.92765307
41	short-chain fatty acid metabolic process (GO:0046459)	3.92393068
42	regulation of cholesterol homeostasis (GO:2000188)	3.91512836
43	bile acid metabolic process (GO:0008206)	3.90581656
44	nitrogen cycle metabolic process (GO:0071941)	3.82825786
45	glucuronate metabolic process (GO:0019585)	3.82432555
46	uronic acid metabolic process (GO:0006063)	3.82432555
47	drug transport (GO:0015893)	3.81812854
48	respiratory chain complex IV assembly (GO:0008535)	3.78910803
49	cellular glucuronidation (GO:0052695)	3.78821413
50	aldehyde catabolic process (GO:0046185)	3.77050069
51	alpha-linolenic acid metabolic process (GO:0036109)	3.76841628
52	drug catabolic process (GO:0042737)	3.74203332
53	acylglycerol homeostasis (GO:0055090)	3.73499860
54	triglyceride homeostasis (GO:0070328)	3.73499860
55	complement activation, alternative pathway (GO:0006957)	3.72620488
56	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.72349827
57	vitamin transmembrane transport (GO:0035461)	3.71153890
58	fructose metabolic process (GO:0006000)	3.70972701
59	regulation of protein activation cascade (GO:2000257)	3.70714990
60	regulation of triglyceride catabolic process (GO:0010896)	3.68223435
61	regulation of bile acid biosynthetic process (GO:0070857)	3.63932127
62	aspartate family amino acid catabolic process (GO:0009068)	3.61871712
63	negative regulation of fibrinolysis (GO:0051918)	3.60350229
64	high-density lipoprotein particle remodeling (GO:0034375)	3.55016573
65	fatty acid oxidation (GO:0019395)	3.54673170
66	fatty acid beta-oxidation (GO:0006635)	3.53939542
67	bile acid and bile salt transport (GO:0015721)	3.53741724
68	organic acid catabolic process (GO:0016054)	3.53330467
69	carboxylic acid catabolic process (GO:0046395)	3.53330467
70	amino acid salvage (GO:0043102)	3.51146828
71	L-methionine salvage (GO:0071267)	3.51146828
72	L-methionine biosynthetic process (GO:0071265)	3.51146828
73	carnitine metabolic process (GO:0009437)	3.49996424
74	regulation of complement activation (GO:0030449)	3.48385460
75	acetyl-CoA metabolic process (GO:0006084)	3.47465147
76	dicarboxylic acid biosynthetic process (GO:0043650)	3.47198101
77	ketone body metabolic process (GO:1902224)	3.47111642
78	lipid oxidation (GO:0034440)	3.46395865
79	imidazole-containing compound metabolic process (GO:0052803)	3.44995144
80	cytochrome complex assembly (GO:0017004)	3.42579484
81	cellular modified amino acid catabolic process (GO:0042219)	3.42373512
82	fatty acid catabolic process (GO:0009062)	3.41317945
83	coenzyme catabolic process (GO:0009109)	3.39625989
84	benzene-containing compound metabolic process (GO:0042537)	3.38492936
85	regulation of fibrinolysis (GO:0051917)	3.37040329
86	immunoglobulin mediated immune response (GO:0016064)	3.35782319
87	DNA deamination (GO:0045006)	3.35102465
88	monocarboxylic acid catabolic process (GO:0072329)	3.35019543
89	serine family amino acid biosynthetic process (GO:0009070)	3.35006466
90	biotin metabolic process (GO:0006768)	3.33435780
91	branched-chain amino acid metabolic process (GO:0009081)	3.32621301
92	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	3.32462808
93	branched-chain amino acid catabolic process (GO:0009083)	3.31789416
94	exogenous drug catabolic process (GO:0042738)	3.31541012
95	response to mercury ion (GO:0046689)	3.29598064
96	indole-containing compound metabolic process (GO:0042430)	3.28193187
97	plasma lipoprotein particle clearance (GO:0034381)	3.22799400
98	ethanol oxidation (GO:0006069)	3.22560732
99	NADH metabolic process (GO:0006734)	3.21692628
100	regulation of cellular amino acid metabolic process (GO:0006521)	3.20741611
101	phospholipid homeostasis (GO:0055091)	3.14080617
102	cullin deneddylation (GO:0010388)	3.13278832
103	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	3.13072562
104	pantothenate metabolic process (GO:0015939)	3.09736650
105	protein deneddylation (GO:0000338)	3.09103656
106	B cell mediated immunity (GO:0019724)	3.08924096
107	purine deoxyribonucleotide catabolic process (GO:0009155)	3.06954326
108	tricarboxylic acid cycle (GO:0006099)	3.06176897
109	sulfur amino acid metabolic process (GO:0000096)	3.05174240
110	reverse cholesterol transport (GO:0043691)	3.05105913
111	proteasome assembly (GO:0043248)	3.04827906
112	small molecule catabolic process (GO:0044282)	3.04073730
113	pyrimidine-containing compound transmembrane transport (GO:0072531)	3.02850273
114	positive regulation of triglyceride lipase activity (GO:0061365)	3.01851560
115	positive regulation of lipoprotein lipase activity (GO:0051006)	3.01851560
116	response to nitrosative stress (GO:0051409)	2.99164313
117	macroautophagy (GO:0016236)	2.97763429
118	oxidative phosphorylation (GO:0006119)	2.95026205
119	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO	2.92337317
120	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.92144097
121	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.91865409
122	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.90515503
123	cytidine catabolic process (GO:0006216)	2.88778271
124	cytidine deamination (GO:0009972)	2.88778271
125	cytidine metabolic process (GO:0046087)	2.88778271
126	oxaloacetate metabolic process (GO:0006107)	2.86302573
127	water-soluble vitamin biosynthetic process (GO:0042364)	2.84459222
128	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.81886237
129	methionine biosynthetic process (GO:0009086)	2.80994814
130	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.79435649
131	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.75252373
132	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.72924547
133	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.72924547
134	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.72924547
135	succinate metabolic process (GO:0006105)	2.72921745
136	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.72577598
137	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.72577598
138	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	2.70631989
139	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.66476883
140	protein complex biogenesis (GO:0070271)	2.65643755
141	vitamin biosynthetic process (GO:0009110)	2.65224839
142	quinone biosynthetic process (GO:1901663)	2.64456668
143	xenobiotic catabolic process (GO:0042178)	2.64324134
144	DNA double-strand break processing (GO:0000729)	2.63269345
145	S-adenosylmethionine metabolic process (GO:0046500)	2.61038760
146	methionine metabolic process (GO:0006555)	2.60472684
147	negative regulation of ligase activity (GO:0051352)	2.59194400
148	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.59194400
149	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.58919449
150	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.58919449
151	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.58603551
152	positive regulation of B cell differentiation (GO:0045579)	2.58108645
153	purine nucleobase biosynthetic process (GO:0009113)	2.57755701
154	iron-sulfur cluster assembly (GO:0016226)	2.57642305
155	metallo-sulfur cluster assembly (GO:0031163)	2.57642305
156	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.56962346
157	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.56962346
158	purine deoxyribonucleotide metabolic process (GO:0009151)	2.55774282
159	regulation of B cell apoptotic process (GO:0002902)	2.55236508
160	adenosine metabolic process (GO:0046085)	2.54277859
161	mitochondrial respiratory chain complex assembly (GO:0033108)	2.51861497
162	ubiquinone biosynthetic process (GO:0006744)	2.48765823
163	antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)	2.46783142
164	protein neddylation (GO:0045116)	2.46724007
165	regulation of mitochondrial translation (GO:0070129)	2.46502839
166	fat-soluble vitamin biosynthetic process (GO:0042362)	2.45990456
167	aerobic respiration (GO:0009060)	2.45192721
168	deoxyribose phosphate catabolic process (GO:0046386)	2.41931251
169	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.40965209
170	DNA ligation (GO:0006266)	2.39867532
171	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.39496776
172	deoxyribonucleotide catabolic process (GO:0009264)	2.35895931
173	positive regulation of ligase activity (GO:0051351)	2.31188461
174	nucleobase biosynthetic process (GO:0046112)	2.30671081
175	antigen processing and presentation of endogenous antigen (GO:0019883)	2.30646367
176	regulation of cellular amine metabolic process (GO:0033238)	2.29627483
177	aspartate family amino acid biosynthetic process (GO:0009067)	2.29096142
178	DNA catabolic process, exonucleolytic (GO:0000738)	2.28343136
179	protein maturation by protein folding (GO:0022417)	2.27548264
180	L-fucose catabolic process (GO:0042355)	2.26545258
181	fucose catabolic process (GO:0019317)	2.26545258
182	L-fucose metabolic process (GO:0042354)	2.26545258
183	positive regulation of gamma-delta T cell activation (GO:0046645)	2.25706629
184	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.25569657
185	pseudouridine synthesis (GO:0001522)	2.24912731

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	9.82009533
2	RXR_22158963_ChIP-Seq_LIVER_Mouse	7.06663682
3	PPARA_22158963_ChIP-Seq_LIVER_Mouse	6.01547367
4	LXR_22158963_ChIP-Seq_LIVER_Mouse	5.59497496
5	EGR1_23403033_ChIP-Seq_LIVER_Mouse	5.59273473
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.62141002
7	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	4.35803163
8	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	4.01332537
9	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.88871717
10	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.72842587
11	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	3.72489718
12	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	3.52866634
13	GATA1_22025678_ChIP-Seq_K562_Human	3.29566226
14	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.20413316
15	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	3.20330093
16	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.02562386
17	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.79453519
18	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.72985849
19	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.41792552
20	* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.38023777
21	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.31885831
22	VDR_23849224_ChIP-Seq_CD4+_Human	2.25023626
23	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.24606476
24	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.21091226
25	* CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.19900764
26	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	2.19329179
27	FOXP3_21729870_ChIP-Seq_TREG_Human	2.18245131
28	HOXB4_20404135_ChIP-ChIP_EML_Mouse	2.15679972
29	IRF8_21731497_ChIP-ChIP_J774_Mouse	2.08308748
30	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.98294136
31	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.97681892
32	* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.96096769
33	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.95949392
34	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.93109943
35	* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.89062894
36	ELK1_19687146_ChIP-ChIP_HELA_Human	1.86019044
37	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	1.85489567
38	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	1.85009999
39	* SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.82280313
40	DCP1A_22483619_ChIP-Seq_HELA_Human	1.80611156
41	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.80426702
42	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.80205367
43	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.78532285
44	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.74939148
45	CLOCK_20551151_ChIP-Seq_293T_Human	1.71829636
46	* GABP_19822575_ChIP-Seq_HepG2_Human	1.67720817
47	SPI1_23547873_ChIP-Seq_NB4_Human	1.67351270
48	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.65187023
49	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.60605324
50	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.54235284
51	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.50226501
52	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.47483517
53	HNF4A_19822575_ChIP-Seq_HepG2_Human	1.43299684
54	* E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.40953579
55	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.40638496
56	* MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.39218687
57	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.38880881
58	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.38697524
59	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.38697524
60	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.38045479
61	* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.37543637
62	CIITA_25753668_ChIP-Seq_RAJI_Human	1.34504489
63	MYB_26560356_Chip-Seq_TH2_Human	1.34160415
64	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.34135421
65	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.31690912
66	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.30197314
67	SALL4_18804426_ChIP-ChIP_XEN_Mouse	1.27501168
68	E2F7_22180533_ChIP-Seq_HELA_Human	1.24164121
69	* ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.24004386
70	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.22526392
71	* MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.22296165
72	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	1.21824799
73	GATA3_26560356_Chip-Seq_TH2_Human	1.20678247
74	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.19979750
75	ZNF274_21170338_ChIP-Seq_K562_Hela	1.19589367
76	TFEB_21752829_ChIP-Seq_HELA_Human	1.19434785
77	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.17945084
78	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.14881781
79	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.13629834
80	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.13625840
81	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.13250383
82	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.12657587
83	IRF8_27001747_Chip-Seq_BMDM_Mouse	1.12482357
84	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.12472169
85	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.11632015
86	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.10484790
87	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.06613253
88	* TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.06079087
89	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.04899501
90	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	1.04520765
91	* SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.04379355
92	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.04351773
93	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.04343111
94	HTT_18923047_ChIP-ChIP_STHdh_Human	1.04268446
95	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.03191470
96	* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.01184592
97	RXRA_24833708_ChIP-Seq_LIVER_Mouse	0.98238337
98	STAT4_19710469_ChIP-ChIP_TH1__Mouse	0.97488935
99	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.97280203
100	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.96553916
101	GATA4_25053715_ChIP-Seq_YYC3_Human	0.96001964
102	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	0.94617605
103	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	0.94375298
104	ZFX_18555785_ChIP-Seq_MESCs_Mouse	0.91852319
105	GATA3_27048872_Chip-Seq_THYMUS_Human	0.89578364
106	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.88441937
107	ZNF263_19887448_ChIP-Seq_K562_Human	0.88103168
108	* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.87822411
109	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.87250907
110	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.87077571
111	* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.87018277
112	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.86589799
113	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.86404271
114	* MYB_26560356_Chip-Seq_TH1_Human	0.85153643
115	MYB_21317192_ChIP-Seq_ERMYB_Mouse	0.83688913
116	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	0.82846361
117	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.81843834
118	CBP_21632823_ChIP-Seq_H3396_Human	0.81279674
119	MYC_18940864_ChIP-ChIP_HL60_Human	0.81049298
120	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.80855880
121	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.80853572
122	IGF1R_20145208_ChIP-Seq_DFB_Human	0.80689930
123	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	0.80652089
124	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.79995161
125	KDM5A_27292631_Chip-Seq_BREAST_Human	0.79971505
126	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.79296662
127	GATA2_21666600_ChIP-Seq_HMVEC_Human	0.76699943
128	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.75288727
129	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	0.74108375
130	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	0.71060186
131	* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse	0.70496872
132	FOXA1_25552417_ChIP-Seq_VCAP_Human	0.69975962
133	FOXO3_23340844_ChIP-Seq_DLD1_Human	0.69789926
134	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.69321209
135	SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	0.68241452
136	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.67996263
137	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.66332074
138	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.66130304
139	MYC_19915707_ChIP-ChIP_AK7_Human	0.63353664
140	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.62842252
141	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.62567129
142	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	0.62321223
143	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.62288088
144	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.61357726
145	RARA_24833708_ChIP-Seq_LIVER_Mouse	0.61082684
146	STAT1_17558387_ChIP-Seq_HELA_Human	0.60607313
147	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.59632782
148	* SOX2_20726797_ChIP-Seq_SW620_Human	0.59571235
149	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	0.58837358
150	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	0.58648210
151	AR_20517297_ChIP-Seq_VCAP_Human	0.58515092
152	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.58373390
153	GATA1_19941826_ChIP-Seq_K562_Human	0.57528307
154	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.57317792
155	RXR_22108803_ChIP-Seq_LS180_Human	0.57090356
156	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.56589462
157	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.56385048
158	RARB_24833708_ChIP-Seq_LIVER_Mouse	0.55560431
159	NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	0.55030885
160	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.54235532
161	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	0.53779667
162	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.53664761
163	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.53625238
164	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.53377636
165	OCT4_20526341_ChIP-Seq_ESCs_Human	0.52972845
166	ESET_19884257_ChIP-Seq_ESCs_Mouse	0.52945532
167	KLF4_19829295_ChIP-Seq_ESCs_Human	0.51732367
168	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	0.51122055
169	* CDX2_22108803_ChIP-Seq_LS180_Human	0.50842368
170	FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	0.50694105
171	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.50655526
172	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.50577947
173	PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse	0.48519636
174	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.48462365
175	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.48430081
176	TAF2_19829295_ChIP-Seq_ESCs_Human	0.47476814
177	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.46519731
178	GATA2_19941826_ChIP-Seq_K562_Human	0.44994218

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	7.32585991
2	MP0005360_urolithiasis	6.60782543
3	MP0005365_abnormal_bile_salt	5.04947226
4	MP0005085_abnormal_gallbladder_physiolo	5.03473686
5	MP0003195_calcinosis	4.29107089
6	MP0008875_abnormal_xenobiotic_pharmacok	4.08558196
7	MP0003806_abnormal_nucleotide_metabolis	3.80631755
8	MP0003252_abnormal_bile_duct	3.62309122
9	MP0005332_abnormal_amino_acid	3.34947367
10	MP0010329_abnormal_lipoprotein_level	2.82003428
11	MP0004019_abnormal_vitamin_homeostasis	2.77753346
12	MP0009840_abnormal_foam_cell	2.70817473
13	MP0004043_abnormal_pH_regulation	2.63199552
14	MP0001835_abnormal_antigen_presentation	2.51339634
15	MP0002138_abnormal_hepatobiliary_system	2.27469538
16	MP0005075_abnormal_melanosome_morpholog	2.27289209
17	MP0001666_abnormal_nutrient_absorption	2.18514930
18	MP0003191_abnormal_cellular_cholesterol	2.17854874
19	MP0002118_abnormal_lipid_homeostasis	2.07676545
20	MP0009643_abnormal_urine_homeostasis	2.05901733
21	MP0004147_increased_porphyrin_level	1.92324077
22	MP0000609_abnormal_liver_physiology	1.91468263
23	MP0009785_altered_susceptibility_to	1.90615336
24	MP0005083_abnormal_biliary_tract	1.86256602
25	MP0005451_abnormal_body_composition	1.83957220
26	MP0005319_abnormal_enzyme/_coenzyme	1.78215090
27	MP0005058_abnormal_lysosome_morphology	1.74351515
28	MP0003183_abnormal_peptide_metabolism	1.71198472
29	MP0003868_abnormal_feces_composition	1.65952161
30	MP0010234_abnormal_vibrissa_follicle	1.65711574
31	MP0002166_altered_tumor_susceptibility	1.61900804
32	MP0002876_abnormal_thyroid_physiology	1.61754253
33	MP0005636_abnormal_mineral_homeostasis	1.60408005
34	MP0002148_abnormal_hypersensitivity_rea	1.53916390
35	MP0010094_abnormal_chromosome_stability	1.53404839
36	MP0001756_abnormal_urination	1.53158024
37	MP0005584_abnormal_enzyme/coenzyme_acti	1.52559709
38	MP0001764_abnormal_homeostasis	1.51108552
39	MP0001765_abnormal_ion_homeostasis	1.50540131
40	MP0005670_abnormal_white_adipose	1.50378361
41	MP0001800_abnormal_humoral_immune	1.40792729
42	MP0005025_abnormal_response_to	1.38728685
43	MP0003303_peritoneal_inflammation	1.37552358
44	MP0002419_abnormal_innate_immunity	1.36705675
45	MP0005671_abnormal_response_to	1.35726437
46	MP0009333_abnormal_splenocyte_physiolog	1.33519834
47	MP0003186_abnormal_redox_activity	1.33428483
48	MP0002078_abnormal_glucose_homeostasis	1.32768201
49	MP0003693_abnormal_embryo_hatching	1.31519315
50	MP0006054_spinal_hemorrhage	1.31203605
51	MP0005000_abnormal_immune_tolerance	1.30610752
52	MP0008058_abnormal_DNA_repair	1.29119310
53	MP0006082_CNS_inflammation	1.28196386
54	MP0004130_abnormal_muscle_cell	1.25372245
55	MP0002452_abnormal_antigen_presenting	1.25089049
56	MP0008260_abnormal_autophagy	1.22458324
57	MP0006036_abnormal_mitochondrial_physio	1.22059502
58	MP0002006_tumorigenesis	1.21287822
59	MP0003075_altered_response_to	1.20996642
60	MP0000015_abnormal_ear_pigmentation	1.19316224
61	MP0002723_abnormal_immune_serum	1.18160197
62	MP0003763_abnormal_thymus_physiology	1.17418124
63	MP0005084_abnormal_gallbladder_morpholo	1.17091870
64	MP0002420_abnormal_adaptive_immunity	1.16574601
65	MP0001819_abnormal_immune_cell	1.14997558
66	MP0001790_abnormal_immune_system	1.14943990
67	MP0005387_immune_system_phenotype	1.14943990
68	MP0009764_decreased_sensitivity_to	1.13540273
69	MP0010155_abnormal_intestine_physiology	1.12899054
70	MP0000465_gastrointestinal_hemorrhage	1.12555486
71	MP0000689_abnormal_spleen_morphology	1.12420102
72	MP0008007_abnormal_cellular_replicative	1.11006756
73	MP0002136_abnormal_kidney_physiology	1.10519450
74	MP0005220_abnormal_exocrine_pancreas	1.09944318
75	MP0005165_increased_susceptibility_to	1.08289786
76	MP0001661_extended_life_span	1.04774934
77	MP0000013_abnormal_adipose_tissue	1.04018621
78	MP0008872_abnormal_physiological_respon	1.03688606
79	MP0005535_abnormal_body_temperature	1.03195737
80	MP0002132_abnormal_respiratory_system	1.02389691
81	MP0002837_dystrophic_cardiac_calcinosis	1.02278098
82	MP0002928_abnormal_bile_duct	1.01173793
83	MP0003786_premature_aging	1.00315903
84	MP0003724_increased_susceptibility_to	0.99153932
85	MP0000604_amyloidosis	0.98073869
86	MP0009642_abnormal_blood_homeostasis	0.97696247
87	MP0003172_abnormal_lysosome_physiology	0.97656685
88	MP0003866_abnormal_defecation	0.96210534
89	MP0000598_abnormal_liver_morphology	0.96046031
90	MP0005645_abnormal_hypothalamus_physiol	0.95457852
91	MP0002693_abnormal_pancreas_physiology	0.95300742
92	MP0002398_abnormal_bone_marrow	0.93646705
93	MP0000716_abnormal_immune_system	0.93348218
94	MP0001944_abnormal_pancreas_morphology	0.93039374
95	MP0004215_abnormal_myocardial_fiber	0.91619297
96	MP0008469_abnormal_protein_level	0.91089528
97	MP0009763_increased_sensitivity_to	0.88204631
98	MP0000230_abnormal_systemic_arterial	0.87906806
99	MP0002722_abnormal_immune_system	0.87723794
100	MP0003690_abnormal_glial_cell	0.85584951
101	MP0000685_abnormal_immune_system	0.85548082
102	MP0005666_abnormal_adipose_tissue	0.85406510
103	MP0003329_amyloid_beta_deposits	0.84917865
104	MP0006035_abnormal_mitochondrial_morpho	0.84007780
105	MP0002429_abnormal_blood_cell	0.82608671
106	MP0003953_abnormal_hormone_level	0.81158967
107	MP0002971_abnormal_brown_adipose	0.81059600
108	MP0008057_abnormal_DNA_replication	0.80601914
109	MP0005334_abnormal_fat_pad	0.77602208
110	MP0001853_heart_inflammation	0.76546714
111	MP0000747_muscle_weakness	0.74919648
112	MP0002877_abnormal_melanocyte_morpholog	0.74479536
113	MP0004957_abnormal_blastocyst_morpholog	0.74474437
114	MP0000678_abnormal_parathyroid_gland	0.73537824
115	MP0005395_other_phenotype	0.71526277
116	MP0002168_other_aberrant_phenotype	0.71003319
117	MP0009765_abnormal_xenobiotic_induced	0.70746556
118	MP0008961_abnormal_basal_metabolism	0.70148079
119	MP0005647_abnormal_sex_gland	0.69320268
120	MP0005375_adipose_tissue_phenotype	0.69293652
121	MP0009780_abnormal_chondrocyte_physiolo	0.67965142
122	MP0005376_homeostasis/metabolism_phenot	0.66812120
123	MP0005448_abnormal_energy_balance	0.66775283
124	MP0003656_abnormal_erythrocyte_physiolo	0.62329615
125	MP0000003_abnormal_adipose_tissue	0.60173317
126	MP0005266_abnormal_metabolism	0.60155772
127	MP0003718_maternal_effect	0.58743385
128	MP0002909_abnormal_adrenal_gland	0.58685577
129	MP0010386_abnormal_urinary_bladder	0.56630254
130	MP0003959_abnormal_lean_body	0.55567067
131	MP0003879_abnormal_hair_cell	0.54455718
132	MP0009697_abnormal_copulation	0.54106739
133	MP0005330_cardiomyopathy	0.50011414
134	MP0002822_catalepsy	0.48677693
135	MP0005379_endocrine/exocrine_gland_phen	0.48513826
136	MP0005166_decreased_susceptibility_to	0.48495962
137	MP0002896_abnormal_bone_mineralization	0.47774507
138	MP0002269_muscular_atrophy	0.46942681
139	MP0003638_abnormal_response/metabolism_	0.45749694
140	MP0001881_abnormal_mammary_gland	0.43665583
141	MP0000920_abnormal_myelination	0.43646969
142	MP0008874_decreased_physiological_sensi	0.42926055
143	MP0003221_abnormal_cardiomyocyte_apopto	0.42558695
144	MP0004264_abnormal_extraembryonic_tissu	0.42473723
145	MP0003436_decreased_susceptibility_to	0.41907147
146	MP0005408_hypopigmentation	0.41866988
147	MP0001502_abnormal_circadian_rhythm	0.41351138
148	MP0001845_abnormal_inflammatory_respons	0.41029191
149	MP0005464_abnormal_platelet_physiology	0.40380120

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of aromatic amino acid family metabolism (HP:0004338)	5.69474161
2	Intrahepatic cholestasis (HP:0001406)	5.30719629
3	Hyperglycinuria (HP:0003108)	5.03455853
4	Hyperglycinemia (HP:0002154)	4.84590738
5	Abnormality of monocarboxylic acid metabolism (HP:0010996)	4.73382713
6	Gout (HP:0001997)	4.63912936
7	Xanthomatosis (HP:0000991)	4.54396624
8	Abnormality of serine family amino acid metabolism (HP:0010894)	4.51554375
9	Abnormality of glycine metabolism (HP:0010895)	4.51554375
10	Hypoglycemic coma (HP:0001325)	4.32387310
11	Prolonged partial thromboplastin time (HP:0003645)	4.29447963
12	Abnormality of glutamine family amino acid metabolism (HP:0010902)	4.23271888
13	Ketosis (HP:0001946)	4.02131249
14	Deep venous thrombosis (HP:0002625)	4.00071644
15	Generalized aminoaciduria (HP:0002909)	3.88573454
16	Hyperlipoproteinemia (HP:0010980)	3.85799307
17	Ketoacidosis (HP:0001993)	3.78526053
18	Microvesicular hepatic steatosis (HP:0001414)	3.74758265
19	Conjugated hyperbilirubinemia (HP:0002908)	3.68025929
20	Abnormality of purine metabolism (HP:0004352)	3.62402773
21	Abnormality of fatty-acid metabolism (HP:0004359)	3.61887420
22	Hepatocellular necrosis (HP:0001404)	3.59814274
23	Hepatic necrosis (HP:0002605)	3.55489623
24	Abnormality of sulfur amino acid metabolism (HP:0004339)	3.53458455
25	Hypoglycemic seizures (HP:0002173)	3.51298878
26	Abnormality of aspartate family amino acid metabolism (HP:0010899)	3.48056884
27	Hypobetalipoproteinemia (HP:0003563)	3.45243074
28	Hyperammonemia (HP:0001987)	3.44974765
29	Symptomatic seizures (HP:0011145)	3.34071513
30	Hyperinsulinemic hypoglycemia (HP:0000825)	3.31597402
31	Abnormality of the common coagulation pathway (HP:0010990)	3.29270923
32	Abnormal mitochondria in muscle tissue (HP:0008316)	3.28372785
33	Hyperuricemia (HP:0002149)	3.28250203
34	Increased purine levels (HP:0004368)	3.28250203
35	B lymphocytopenia (HP:0010976)	3.24269580
36	Mitochondrial inheritance (HP:0001427)	3.19191069
37	Acute necrotizing encephalopathy (HP:0006965)	3.18250998
38	Abnormality of B cell number (HP:0010975)	3.16300271
39	Abnormality of nucleobase metabolism (HP:0010932)	3.13425486
40	Abnormality of serum amino acid levels (HP:0003112)	3.13136352
41	Joint hemorrhage (HP:0005261)	3.11191365
42	Abnormality of methionine metabolism (HP:0010901)	3.10396941
43	Abnormality of the intrinsic pathway (HP:0010989)	3.09716486
44	Increased CSF lactate (HP:0002490)	3.08013960
45	Fat malabsorption (HP:0002630)	3.07495112
46	Complement deficiency (HP:0004431)	3.06882205
47	Acute encephalopathy (HP:0006846)	3.02158165
48	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.96440307
49	Dicarboxylic aciduria (HP:0003215)	2.96440307
50	Palpitations (HP:0001962)	2.93894388
51	Abnormality of proline metabolism (HP:0010907)	2.91769975
52	Hydroxyprolinuria (HP:0003080)	2.91769975
53	Hyperglycemia (HP:0003074)	2.91375619
54	Hypolipoproteinemia (HP:0010981)	2.90107337
55	Increased serum pyruvate (HP:0003542)	2.89914521
56	Hypoalphalipoproteinemia (HP:0003233)	2.85015254
57	Progressive macrocephaly (HP:0004481)	2.80658886
58	Proximal tubulopathy (HP:0000114)	2.80156889
59	Epidermoid cyst (HP:0200040)	2.79890229
60	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	2.79569112
61	Increased circulating renin level (HP:0000848)	2.79205692
62	Increased intramyocellular lipid droplets (HP:0012240)	2.73541572
63	Increased muscle lipid content (HP:0009058)	2.72081596
64	Alkalosis (HP:0001948)	2.70840983
65	Hyperactive renin-angiotensin system (HP:0000841)	2.70743616
66	Lactic acidosis (HP:0003128)	2.67512574
67	Metabolic acidosis (HP:0001942)	2.64373559
68	Acute hepatic failure (HP:0006554)	2.64170004
69	Hypokalemic alkalosis (HP:0001949)	2.63261158
70	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.62912607
71	Aplastic anemia (HP:0001915)	2.62879318
72	Abnormality of glycolysis (HP:0004366)	2.61387997
73	Abnormality of vitamin B metabolism (HP:0004340)	2.61160305
74	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.58620598
75	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.58620598
76	Irritability (HP:0000737)	2.55349342
77	Lethargy (HP:0001254)	2.55284473
78	Hyperbilirubinemia (HP:0002904)	2.55238070
79	Rhabdomyolysis (HP:0003201)	2.51885649
80	Abnormality of urine glucose concentration (HP:0011016)	2.47749204
81	Glycosuria (HP:0003076)	2.47749204
82	Increased serum lactate (HP:0002151)	2.46090549
83	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.43989968
84	Methylmalonic acidemia (HP:0002912)	2.43437550
85	Ragged-red muscle fibers (HP:0003200)	2.43424598
86	Respiratory failure (HP:0002878)	2.37294275
87	Myocardial infarction (HP:0001658)	2.37168622
88	Methylmalonic aciduria (HP:0012120)	2.36901628
89	Abnormal enzyme/coenzyme activity (HP:0012379)	2.35895494
90	Confusion (HP:0001289)	2.34062618
91	Pancreatic islet-cell hyperplasia (HP:0004510)	2.32924237
92	Late onset (HP:0003584)	2.32877522
93	Delayed CNS myelination (HP:0002188)	2.32838931
94	CNS demyelination (HP:0007305)	2.31967658
95	Vascular calcification (HP:0004934)	2.28880937
96	Polyuria (HP:0000103)	2.25381570
97	Abnormality of complement system (HP:0005339)	2.24181432
98	Abnormality of alkaline phosphatase activity (HP:0004379)	2.23784128
99	Elevated alkaline phosphatase (HP:0003155)	2.22932052
100	Abnormal urine output (HP:0012590)	2.21074084
101	Steatorrhea (HP:0002570)	2.20765657
102	Petechiae (HP:0000967)	2.20185394
103	Rickets (HP:0002748)	2.20064081
104	Elevated erythrocyte sedimentation rate (HP:0003565)	2.19140511
105	Metabolic alkalosis (HP:0200114)	2.18298733
106	Skin nodule (HP:0200036)	2.17528676
107	Pancreatitis (HP:0001733)	2.16187850
108	Abnormality of pyrimidine metabolism (HP:0004353)	2.15470913
109	Lipid accumulation in hepatocytes (HP:0006561)	2.14932445
110	Insulin-resistant diabetes mellitus (HP:0000831)	2.13675854
111	Abnormality of chloride homeostasis (HP:0011422)	2.12758848
112	Hypophosphatemia (HP:0002148)	2.12746379
113	Chronic diarrhea (HP:0002028)	2.12367295
114	Vacuolated lymphocytes (HP:0001922)	2.09913277
115	Abnormality of the prostate (HP:0008775)	2.09540863
116	Hypomagnesemia (HP:0002917)	2.08448158
117	Vomiting (HP:0002013)	2.07963913
118	Stomatitis (HP:0010280)	2.07608298
119	IgM deficiency (HP:0002850)	2.07546951
120	Sensorimotor neuropathy (HP:0007141)	2.07087372
121	Hypercholesterolemia (HP:0003124)	2.06661325
122	Abnormal protein glycosylation (HP:0012346)	2.06465003
123	Abnormal glycosylation (HP:0012345)	2.06465003
124	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.06465003
125	Abnormal protein N-linked glycosylation (HP:0012347)	2.06465003
126	Axonal loss (HP:0003447)	2.04699558
127	Systemic lupus erythematosus (HP:0002725)	2.00943108
128	Type I transferrin isoform profile (HP:0003642)	2.00092534
129	Protuberant abdomen (HP:0001538)	1.98435869
130	Severe combined immunodeficiency (HP:0004430)	1.98275156
131	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.97885256
132	Abnormality of alanine metabolism (HP:0010916)	1.97885256
133	Hyperalaninemia (HP:0003348)	1.97885256
134	Cerebral palsy (HP:0100021)	1.97610335
135	Cerebral edema (HP:0002181)	1.97583016
136	Abnormality of vitamin metabolism (HP:0100508)	1.97486795
137	Hypothermia (HP:0002045)	1.97240326
138	Neoplasm of the adrenal gland (HP:0100631)	1.96480581
139	Cardiovascular calcification (HP:0011915)	1.96250217
140	Exercise intolerance (HP:0003546)	1.95442696
141	Abnormality of renal excretion (HP:0011036)	1.94935016
142	Polydipsia (HP:0001959)	1.94628309
143	Abnormal drinking behavior (HP:0030082)	1.94628309
144	Emotional lability (HP:0000712)	1.93679211
145	Recurrent abscess formation (HP:0002722)	1.93125349
146	Progressive neurologic deterioration (HP:0002344)	1.92984339
147	Opisthotonus (HP:0002179)	1.92893409
148	Mitral stenosis (HP:0001718)	1.90800772
149	Abnormality of the pancreatic islet cells (HP:0006476)	1.89576286
150	Abnormality of endocrine pancreas physiology (HP:0012093)	1.89576286
151	Abnormality of renin-angiotensin system (HP:0000847)	1.89257518
152	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	1.89130145
153	Abnormality of magnesium homeostasis (HP:0004921)	1.89035532
154	Renal Fanconi syndrome (HP:0001994)	1.88114678
155	Tetany (HP:0001281)	1.86183914
156	Reduced antithrombin III activity (HP:0001976)	1.86082596
157	Nausea (HP:0002018)	1.83934696
158	Megaloblastic anemia (HP:0001889)	1.83714501
159	Limb hypertonia (HP:0002509)	1.82003461
160	Tetraplegia (HP:0002445)	1.80766183
161	Abnormal pupillary function (HP:0007686)	1.80721212
162	Albinism (HP:0001022)	1.80101253
163	Abnormality of iron homeostasis (HP:0011031)	1.79865467
164	Increased hepatocellular lipid droplets (HP:0006565)	1.78831323
165	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.78378448
166	Cerebral hypomyelination (HP:0006808)	1.71753301
167	Elevated hepatic transaminases (HP:0002910)	1.70667900
168	Multiple enchondromatosis (HP:0005701)	1.70466573
169	3-Methylglutaconic aciduria (HP:0003535)	1.70186837
170	Abnormality of transition element cation homeostasis (HP:0011030)	1.67373672

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BCKDK	4.81249108
2	MST4	4.06591669
3	WNK3	3.67406751
4	VRK2	3.64686179
5	TAOK3	3.58206846
6	INSRR	3.51030863
7	WNK4	3.18290488
8	IRAK3	3.11694939
9	OXSR1	3.01489717
10	MAP3K12	2.75259128
11	MAPK15	2.66190141
12	PINK1	2.60656020
13	FLT3	2.48106001
14	AKT3	2.31780822
15	PIK3CG	2.27075407
16	SIK1	2.23447847
17	FGFR4	2.09054228
18	NEK1	2.00332902
19	NUAK1	1.94952115
20	MAP3K14	1.83687449
21	CAMKK2	1.83164612
22	SCYL2	1.82903759
23	EPHA2	1.80759017
24	BMPR2	1.77123474
25	ZAK	1.75514587
26	DAPK1	1.70324440
27	TAF1	1.65531220
28	MAP4K1	1.60931747
29	EIF2AK1	1.60177430
30	ERBB4	1.59198176
31	BMPR1B	1.58015101
32	FRK	1.56439940
33	TEC	1.55797759
34	MAP4K2	1.54378736
35	TRIM28	1.53795201
36	TESK1	1.52903400
37	MAP2K4	1.52378505
38	PDK2	1.50591360
39	TSSK6	1.48312264
40	TESK2	1.45188487
41	MAP2K7	1.44781341
42	STK38L	1.43583682
43	TNIK	1.37673493
44	ACVR1B	1.33009415
45	BUB1	1.32023777
46	MET	1.28263111
47	MST1R	1.25437122
48	CSNK1G1	1.23421307
49	ERBB3	1.22539219
50	SRPK1	1.20789183
51	KDR	1.20717132
52	CSNK1G3	1.20125650
53	MAP3K3	1.16657474
54	IKBKE	1.15358575
55	MAP3K2	1.13417546
56	MAP3K4	1.10306377
57	PIM2	1.09694170
58	ABL2	1.03732988
59	EIF2AK3	1.03234978
60	SYK	1.01907354
61	PRKAA2	1.01426085
62	IRAK2	0.99711674
63	VRK1	0.98525072
64	CCNB1	0.96758606
65	MAP3K11	0.95221985
66	NEK6	0.94739637
67	SGK494	0.93327680
68	SGK223	0.93327680
69	LIMK1	0.91969585
70	DAPK2	0.91790678
71	TYK2	0.90898326
72	STK16	0.89651608
73	ERN1	0.89603573
74	STK39	0.88871945
75	PLK3	0.87632923
76	MAP3K13	0.87382358
77	TBK1	0.87301997
78	PRKAA1	0.86641071
79	EIF2AK2	0.86612320
80	CSF1R	0.85806017
81	MAPK11	0.84204242
82	RAF1	0.83746797
83	STK38	0.79222614
84	FER	0.77644652
85	ZAP70	0.75647213
86	JAK2	0.75282050
87	OBSCN	0.75121869
88	PTK2	0.74172723
89	TNK2	0.74136632
90	EPHA4	0.72893862
91	NLK	0.72157811
92	BTK	0.71815979
93	CAMK2G	0.71768998
94	MUSK	0.70068164
95	PRKCI	0.68865897
96	PDK4	0.68029774
97	PDK3	0.68029774
98	LYN	0.66063056
99	GRK1	0.65506737
100	CDK3	0.65103809
101	LATS1	0.64359078
102	JAK1	0.63741177
103	SGK2	0.62560022
104	SGK3	0.61547406
105	WNK1	0.61090377
106	MAP3K5	0.60771264
107	BRSK2	0.58427842
108	IRAK1	0.58379062
109	KIT	0.57136520
110	NME2	0.56958815
111	PRKCH	0.55737940
112	MAP3K7	0.55075479
113	PBK	0.54424804
114	PLK1	0.54031122
115	PDPK1	0.54004248
116	CAMKK1	0.53993565
117	TTN	0.53749228
118	PRKCQ	0.53168892
119	TXK	0.52916136
120	GRK7	0.52572062
121	BCR	0.51549838
122	FGR	0.51167037
123	MATK	0.51154664
124	TIE1	0.50925418
125	DYRK2	0.50616994
126	PRKACG	0.50466833
127	RIPK4	0.50465888
128	EPHA3	0.50316506
129	MAPK7	0.49840071
130	PTK6	0.49273876
131	IGF1R	0.49125499
132	LCK	0.47892788
133	NTRK3	0.47696825
134	SIK3	0.47107532
135	MYLK	0.45929611
136	FES	0.44676471
137	NEK9	0.44551270
138	ADRBK2	0.44523607
139	ALK	0.44358148
140	BMX	0.43579101
141	PAK3	0.43558169
142	STK10	0.43408303
143	SGK1	0.42036767
144	BLK	0.41920706
145	JAK3	0.41495948
146	CLK1	0.41237844
147	CSNK1A1L	0.40283099
148	CAMK2D	0.40158155
149	ATR	0.40095558
150	PKN1	0.39837566
151	GSK3A	0.39361557
152	MINK1	0.38983445
153	NME1	0.38648629
154	CAMK2B	0.38490621
155	ITK	0.38159275
156	CDK6	0.38107001
157	MAP3K1	0.37781179
158	PRKCG	0.37637608
159	CAMK1D	0.37586153
160	AURKB	0.37213058
161	ABL1	0.35646747
162	ARAF	0.34931843
163	CSK	0.33261701
164	PKN2	0.33149839
165	IKBKB	0.32464967
166	PRKCE	0.32091577
167	BRD4	0.31156795
168	CSNK1A1	0.31146357
169	PRKCA	0.30061263
170	CSNK1G2	0.30033311
171	SIK2	0.29481165
172	EPHB1	0.24582820

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.43567201
2	Primary bile acid biosynthesis_Homo sapiens_hsa00120	3.32749918
3	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.96210287
4	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.92907272
5	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.86628063
6	Nitrogen metabolism_Homo sapiens_hsa00910	2.84084948
7	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.74546193
8	Butanoate metabolism_Homo sapiens_hsa00650	2.73902070
9	Tryptophan metabolism_Homo sapiens_hsa00380	2.67863628
10	Fatty acid degradation_Homo sapiens_hsa00071	2.48942407
11	Arginine biosynthesis_Homo sapiens_hsa00220	2.48366440
12	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.44531905
13	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.41721479
14	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.28147049
15	Peroxisome_Homo sapiens_hsa04146	2.12018486
16	Propanoate metabolism_Homo sapiens_hsa00640	2.09080608
17	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.94716537
18	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.94373566
19	Complement and coagulation cascades_Homo sapiens_hsa04610	1.90082593
20	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.89802573
21	beta-Alanine metabolism_Homo sapiens_hsa00410	1.85443999
22	Type I diabetes mellitus_Homo sapiens_hsa04940	1.78000136
23	Sulfur metabolism_Homo sapiens_hsa00920	1.77886119
24	Asthma_Homo sapiens_hsa05310	1.77823280
25	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.75596488
26	Fatty acid metabolism_Homo sapiens_hsa01212	1.74299098
27	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.73254233
28	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.72947851
29	Oxidative phosphorylation_Homo sapiens_hsa00190	1.66953796
30	PPAR signaling pathway_Homo sapiens_hsa03320	1.66649810
31	Histidine metabolism_Homo sapiens_hsa00340	1.66110364
32	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.65989413
33	Allograft rejection_Homo sapiens_hsa05330	1.65815977
34	Selenocompound metabolism_Homo sapiens_hsa00450	1.64312786
35	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.62843686
36	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.59589267
37	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.56732677
38	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.56098722
39	Folate biosynthesis_Homo sapiens_hsa00790	1.55178960
40	Graft-versus-host disease_Homo sapiens_hsa05332	1.44417866
41	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.44412172
42	Parkinsons disease_Homo sapiens_hsa05012	1.42859148
43	Phenylalanine metabolism_Homo sapiens_hsa00360	1.39352510
44	Bile secretion_Homo sapiens_hsa04976	1.37971752
45	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.37260882
46	Chemical carcinogenesis_Homo sapiens_hsa05204	1.35021503
47	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.34063956
48	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.33748624
49	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.33225113
50	Pyruvate metabolism_Homo sapiens_hsa00620	1.32758552
51	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.29665238
52	Steroid biosynthesis_Homo sapiens_hsa00100	1.28284780
53	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.28081818
54	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.26903150
55	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.25468113
56	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.23984540
57	Carbon metabolism_Homo sapiens_hsa01200	1.23438192
58	Primary immunodeficiency_Homo sapiens_hsa05340	1.19641645
59	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.17305444
60	Mismatch repair_Homo sapiens_hsa03430	1.16663277
61	Arginine and proline metabolism_Homo sapiens_hsa00330	1.16489552
62	Fatty acid elongation_Homo sapiens_hsa00062	1.14969695
63	Retinol metabolism_Homo sapiens_hsa00830	1.14190784
64	Tyrosine metabolism_Homo sapiens_hsa00350	1.13038781
65	ABC transporters_Homo sapiens_hsa02010	1.10854782
66	Non-homologous end-joining_Homo sapiens_hsa03450	1.10849166
67	Caffeine metabolism_Homo sapiens_hsa00232	1.10812904
68	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.09400493
69	Base excision repair_Homo sapiens_hsa03410	1.07636844
70	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.04829890
71	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.03421543
72	Antigen processing and presentation_Homo sapiens_hsa04612	1.00210179
73	DNA replication_Homo sapiens_hsa03030	0.98598783
74	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.94156562
75	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.93674020
76	Homologous recombination_Homo sapiens_hsa03440	0.84325978
77	Glycerolipid metabolism_Homo sapiens_hsa00561	0.81130029
78	Lysine degradation_Homo sapiens_hsa00310	0.79620176
79	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.79460000
80	RNA polymerase_Homo sapiens_hsa03020	0.78124785
81	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.76351189
82	Regulation of autophagy_Homo sapiens_hsa04140	0.74297884
83	Collecting duct acid secretion_Homo sapiens_hsa04966	0.72693593
84	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.72678678
85	Pyrimidine metabolism_Homo sapiens_hsa00240	0.71361112
86	Fat digestion and absorption_Homo sapiens_hsa04975	0.70159985
87	Glutathione metabolism_Homo sapiens_hsa00480	0.69080833
88	Purine metabolism_Homo sapiens_hsa00230	0.68627658
89	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.68451946
90	Viral myocarditis_Homo sapiens_hsa05416	0.66902791
91	Legionellosis_Homo sapiens_hsa05134	0.66723240
92	Alzheimers disease_Homo sapiens_hsa05010	0.65704758
93	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.64681205
94	Lysosome_Homo sapiens_hsa04142	0.64481512
95	Herpes simplex infection_Homo sapiens_hsa05168	0.62845233
96	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.61311591
97	RNA degradation_Homo sapiens_hsa03018	0.61042340
98	Pentose phosphate pathway_Homo sapiens_hsa00030	0.60633188
99	Huntingtons disease_Homo sapiens_hsa05016	0.59268634
100	Nucleotide excision repair_Homo sapiens_hsa03420	0.57746826
101	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.56808610
102	Metabolic pathways_Homo sapiens_hsa01100	0.56282164
103	Sulfur relay system_Homo sapiens_hsa04122	0.56265711
104	One carbon pool by folate_Homo sapiens_hsa00670	0.55077433
105	Basal transcription factors_Homo sapiens_hsa03022	0.52687382
106	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.52178046
107	Leishmaniasis_Homo sapiens_hsa05140	0.50733384
108	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.50358966
109	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.48669184
110	Fanconi anemia pathway_Homo sapiens_hsa03460	0.48199712
111	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.46422125
112	Galactose metabolism_Homo sapiens_hsa00052	0.40979191
113	Insulin resistance_Homo sapiens_hsa04931	0.38786139
114	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.38340530
115	Type II diabetes mellitus_Homo sapiens_hsa04930	0.36953598
116	Other glycan degradation_Homo sapiens_hsa00511	0.30327021
117	Protein export_Homo sapiens_hsa03060	0.28760404
118	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.27814236
119	Circadian rhythm_Homo sapiens_hsa04710	0.25400532
120	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.21947945
121	Prion diseases_Homo sapiens_hsa05020	0.21219489
122	Vibrio cholerae infection_Homo sapiens_hsa05110	0.20584101
123	Glucagon signaling pathway_Homo sapiens_hsa04922	0.15108757
124	Rheumatoid arthritis_Homo sapiens_hsa05323	0.14832031
125	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.13964235
126	Insulin secretion_Homo sapiens_hsa04911	0.11293512
127	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.11005233
128	Mineral absorption_Homo sapiens_hsa04978	0.10998476
129	AMPK signaling pathway_Homo sapiens_hsa04152	0.10524878
130	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.09627742
131	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.09303521
132	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.06891509
133	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.03945774
134	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.03013042
135	Phagosome_Homo sapiens_hsa04145	-0.0357981
136	Inositol phosphate metabolism_Homo sapiens_hsa00562	-0.0290848
137	Sphingolipid metabolism_Homo sapiens_hsa00600	-0.0268598
138	Linoleic acid metabolism_Homo sapiens_hsa00591	-0.0097784

PROSC

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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