PROSER2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polyketide metabolic process (GO:0030638)6.51300891
2doxorubicin metabolic process (GO:0044598)6.51300891
3daunorubicin metabolic process (GO:0044597)6.51300891
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.65648900
5L-phenylalanine metabolic process (GO:0006558)5.65648900
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.65159495
7L-phenylalanine catabolic process (GO:0006559)5.65159495
8aromatic amino acid family catabolic process (GO:0009074)5.52834184
9tryptophan catabolic process (GO:0006569)5.52700706
10indole-containing compound catabolic process (GO:0042436)5.52700706
11indolalkylamine catabolic process (GO:0046218)5.52700706
12kynurenine metabolic process (GO:0070189)5.33893504
13ribosomal small subunit biogenesis (GO:0042274)5.25047506
14tryptophan metabolic process (GO:0006568)5.23396117
15triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.97967161
16hemidesmosome assembly (GO:0031581)4.84221487
17high-density lipoprotein particle remodeling (GO:0034375)4.82465950
18phosphate ion transport (GO:0006817)4.68522003
19pentose metabolic process (GO:0019321)4.64995623
20serine family amino acid catabolic process (GO:0009071)4.64885355
21sulfur amino acid catabolic process (GO:0000098)4.57888692
22homocysteine metabolic process (GO:0050667)4.54297890
23bile acid biosynthetic process (GO:0006699)4.49609523
24amino-acid betaine metabolic process (GO:0006577)4.49229920
25cysteine metabolic process (GO:0006534)4.44932834
26urea metabolic process (GO:0019627)4.44540899
27urea cycle (GO:0000050)4.44540899
28reverse cholesterol transport (GO:0043691)4.39822519
29glyoxylate metabolic process (GO:0046487)4.37338126
30aromatic amino acid family metabolic process (GO:0009072)4.36497560
31amine catabolic process (GO:0009310)4.35605181
32cellular biogenic amine catabolic process (GO:0042402)4.35605181
33protein carboxylation (GO:0018214)4.33271776
34peptidyl-glutamic acid carboxylation (GO:0017187)4.33271776
35maturation of SSU-rRNA (GO:0030490)4.26692162
36intestinal cholesterol absorption (GO:0030299)4.21393236
37negative regulation of fibrinolysis (GO:0051918)4.19518692
38viral transcription (GO:0019083)4.19206767
39cellular glucuronidation (GO:0052695)4.14363696
40regulation of triglyceride catabolic process (GO:0010896)4.13686447
41alpha-linolenic acid metabolic process (GO:0036109)4.11340041
42regulation of protein activation cascade (GO:2000257)4.10412736
43phospholipid efflux (GO:0033700)4.05507911
44translational termination (GO:0006415)4.04797959
45regulation of cholesterol esterification (GO:0010872)4.03237947
46phosphate ion transmembrane transport (GO:0035435)4.02999403
47nitrogen cycle metabolic process (GO:0071941)4.01923829
48protein-lipid complex remodeling (GO:0034368)3.99832462
49macromolecular complex remodeling (GO:0034367)3.99832462
50plasma lipoprotein particle remodeling (GO:0034369)3.99832462
51regulation of fibrinolysis (GO:0051917)3.99729472
52fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.99048723
53aminoglycoside antibiotic metabolic process (GO:0030647)3.97949466
54desmosome organization (GO:0002934)3.97145019
55alpha-amino acid catabolic process (GO:1901606)3.95694533
56bile acid metabolic process (GO:0008206)3.94767918
57detection of molecule of bacterial origin (GO:0032490)3.90247497
58complement activation, alternative pathway (GO:0006957)3.88694879
59indolalkylamine metabolic process (GO:0006586)3.88252176
60glycine metabolic process (GO:0006544)3.84426914
61regulation of complement activation (GO:0030449)3.81259132
62drug catabolic process (GO:0042737)3.78979030
63acylglycerol homeostasis (GO:0055090)3.76995893
64triglyceride homeostasis (GO:0070328)3.76995893
65histone H2A acetylation (GO:0043968)3.75968195
66arginine metabolic process (GO:0006525)3.75073523
67exogenous drug catabolic process (GO:0042738)3.70648735
68uronic acid metabolic process (GO:0006063)3.69451662
69glucuronate metabolic process (GO:0019585)3.69451662
70lysine catabolic process (GO:0006554)3.66321008
71lysine metabolic process (GO:0006553)3.66321008
72rRNA transcription (GO:0009303)3.66057264
73ribosomal large subunit biogenesis (GO:0042273)3.64465631
74imidazole-containing compound metabolic process (GO:0052803)3.63910958
75deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.63758108
76folic acid metabolic process (GO:0046655)3.60396876
77bile acid and bile salt transport (GO:0015721)3.60325208
78cellular amino acid catabolic process (GO:0009063)3.60030726
79peptidyl-tyrosine autophosphorylation (GO:0038083)3.59397637
80NAD biosynthetic process (GO:0009435)3.57604772
81coenzyme catabolic process (GO:0009109)3.57309385
82urate metabolic process (GO:0046415)3.56842277
83tyrosine metabolic process (GO:0006570)3.55843497
84regulation of RNA export from nucleus (GO:0046831)3.53328053
85serine family amino acid metabolic process (GO:0009069)3.52402977
86negative regulation of lipase activity (GO:0060192)3.50303093
87translational elongation (GO:0006414)3.49143442
88plasma lipoprotein particle clearance (GO:0034381)3.48337231
89cholesterol efflux (GO:0033344)3.46743344
90regulation of hippo signaling (GO:0035330)3.46295853
91nicotinamide nucleotide biosynthetic process (GO:0019359)3.45145297
92pyridine nucleotide biosynthetic process (GO:0019363)3.45145297
93regulation of bile acid biosynthetic process (GO:0070857)3.45099590
94nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.44556370
95carnitine metabolic process (GO:0009437)3.40652120
96negative regulation of cholesterol transport (GO:0032375)3.40072274
97negative regulation of sterol transport (GO:0032372)3.40072274
98cellular modified amino acid catabolic process (GO:0042219)3.39404657
99benzene-containing compound metabolic process (GO:0042537)3.36167344
100bundle of His cell to Purkinje myocyte communication (GO:0086069)3.31279570
101serine family amino acid biosynthetic process (GO:0009070)3.31173126
102mitochondrial fusion (GO:0008053)3.28660347
103SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.28432088
104viral life cycle (GO:0019058)3.26264104
105interferon-gamma secretion (GO:0072643)3.25610267
106phospholipid homeostasis (GO:0055091)3.24602986
107positive regulation of lipoprotein lipase activity (GO:0051006)3.23086967
108positive regulation of triglyceride lipase activity (GO:0061365)3.23086967
109regulation of mammary gland epithelial cell proliferation (GO:0033599)3.22577601
110low-density lipoprotein particle remodeling (GO:0034374)3.22096268
111positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.21887023
112fibrinolysis (GO:0042730)3.20341485
113ribosomal small subunit assembly (GO:0000028)3.16014121
114cotranslational protein targeting to membrane (GO:0006613)3.15098620
115blood coagulation, intrinsic pathway (GO:0007597)3.14953579
116protein targeting to ER (GO:0045047)3.14474848
117gap junction assembly (GO:0016264)3.14100472
118negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.14099817
119regulation of cholesterol homeostasis (GO:2000188)3.14021186
120carboxylic acid catabolic process (GO:0046395)3.13622409
121organic acid catabolic process (GO:0016054)3.13622409
122nucleobase-containing small molecule interconversion (GO:0015949)3.13049125
123valine metabolic process (GO:0006573)3.12768609
124detection of external biotic stimulus (GO:0098581)3.11368064
125formation of translation preinitiation complex (GO:0001731)3.10997412
126sulfate transmembrane transport (GO:1902358)3.10397118
127cellular protein complex disassembly (GO:0043624)3.10347014
128muscle cell fate commitment (GO:0042693)3.09147408
129cholesterol homeostasis (GO:0042632)3.06815832
130cell-substrate junction assembly (GO:0007044)3.06617056
131ribonucleoprotein complex biogenesis (GO:0022613)3.05725257
132proline metabolic process (GO:0006560)3.05275402
133heme transport (GO:0015886)3.05159083
134sterol homeostasis (GO:0055092)3.04862607
135negative regulation of fatty acid biosynthetic process (GO:0045717)3.04651283
136peptidyl-arginine omega-N-methylation (GO:0035247)3.03377401
137mitotic chromosome condensation (GO:0007076)3.01528423
138establishment of protein localization to endoplasmic reticulum (GO:0072599)3.00930622
139keratinocyte proliferation (GO:0043616)2.99314402
140regulation of cardioblast differentiation (GO:0051890)2.97151518
141protein localization to endoplasmic reticulum (GO:0070972)2.94180901
142translational initiation (GO:0006413)2.90551178
143pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.89178480
144regulation of nucleobase-containing compound transport (GO:0032239)2.87292419
145proline biosynthetic process (GO:0006561)2.86837159
146establishment of skin barrier (GO:0061436)2.78594819
147regulation of water loss via skin (GO:0033561)2.77516123
148response to vitamin A (GO:0033189)2.76741028
149regulation of response to tumor cell (GO:0002834)2.74925669
150positive regulation of response to tumor cell (GO:0002836)2.74925669
151positive regulation of immune response to tumor cell (GO:0002839)2.74925669
152regulation of immune response to tumor cell (GO:0002837)2.74925669
153regulation of apoptotic process involved in morphogenesis (GO:1902337)2.73693928
154pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.72998919
155protein complex disassembly (GO:0043241)2.71958408
156outflow tract septum morphogenesis (GO:0003148)2.70206139
157mitotic G1 DNA damage checkpoint (GO:0031571)2.65977728
158lymph vessel development (GO:0001945)2.63316649
159regulation of translational fidelity (GO:0006450)2.62715238
160regulation of hair follicle development (GO:0051797)2.61152575
161response to mercury ion (GO:0046689)2.60584227
162spliceosomal tri-snRNP complex assembly (GO:0000244)2.60567028
163heterochromatin organization (GO:0070828)2.60529037
164hypotonic response (GO:0006971)2.59071841
165histone arginine methylation (GO:0034969)2.57797142
166multicellular organismal water homeostasis (GO:0050891)2.54232261
167apoptotic process involved in morphogenesis (GO:0060561)2.53052352
168atrial septum morphogenesis (GO:0060413)2.51841790
169regulation of G0 to G1 transition (GO:0070316)2.50057397
170thyroid gland development (GO:0030878)2.49801451
171macromolecular complex disassembly (GO:0032984)2.48492242
1724-hydroxyproline metabolic process (GO:0019471)2.48240341
173positive regulation of protein export from nucleus (GO:0046827)2.45892453
174glycoside metabolic process (GO:0016137)2.44865812
175focal adhesion assembly (GO:0048041)2.44616445
176cell-substrate adherens junction assembly (GO:0007045)2.44616445
177pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.44032283
178response to parathyroid hormone (GO:0071107)2.43070987
179muscle organ morphogenesis (GO:0048644)2.42301526
180mesodermal cell differentiation (GO:0048333)2.41196117
181epithelial cell-cell adhesion (GO:0090136)2.40992304
182morphogenesis of embryonic epithelium (GO:0016331)2.38374341
183negative regulation of homotypic cell-cell adhesion (GO:0034111)2.37036485
184DNA unwinding involved in DNA replication (GO:0006268)2.36639295
185G1 DNA damage checkpoint (GO:0044783)2.36594476
186pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.36433983
187pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.35055327
188peptidyl-arginine N-methylation (GO:0035246)2.34373036
189peptidyl-arginine methylation (GO:0018216)2.34373036
190response to thyroid hormone (GO:0097066)2.33301848

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.01080923
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.73954875
3PPARA_22158963_ChIP-Seq_LIVER_Mouse6.01761638
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.64092205
5LXR_22158963_ChIP-Seq_LIVER_Mouse5.22570085
6TP63_17297297_ChIP-ChIP_HaCaT_Human5.08349189
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.69175730
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.06223700
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.36987064
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.35952653
11E2F7_22180533_ChIP-Seq_HELA_Human3.31363412
12MYC_18555785_ChIP-Seq_MESCs_Mouse3.01746541
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.92392743
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.85722451
15CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.80057241
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.65496917
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.37730298
18ESR1_21235772_ChIP-Seq_MCF-7_Human2.32637909
19STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.24290954
20MYC_19079543_ChIP-ChIP_MESCs_Mouse2.21040114
21MYC_18358816_ChIP-ChIP_MESCs_Mouse2.08746232
22HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.06879983
23RARG_19884340_ChIP-ChIP_MEFs_Mouse2.05607739
24FOXM1_23109430_ChIP-Seq_U2OS_Human2.01961359
25ELK3_25401928_ChIP-Seq_HUVEC_Human2.01410015
26DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.99712577
27VDR_21846776_ChIP-Seq_THP-1_Human1.96573423
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.91017850
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.88463039
30FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.86277401
31CDX2_20551321_ChIP-Seq_CACO-2_Human1.81952341
32GATA4_25053715_ChIP-Seq_YYC3_Human1.79894982
33MYC_19030024_ChIP-ChIP_MESCs_Mouse1.77342455
34LXR_22292898_ChIP-Seq_THP-1_Human1.74718954
35PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.71538610
36TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.71152312
37KLF4_18555785_ChIP-Seq_MESCs_Mouse1.68773618
38ATF3_27146783_Chip-Seq_COLON_Human1.66472859
39XRN2_22483619_ChIP-Seq_HELA_Human1.65786359
40ZNF263_19887448_ChIP-Seq_K562_Human1.60832239
41ZFX_18555785_ChIP-Seq_MESCs_Mouse1.60804724
42TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56157028
43TRIM28_21343339_ChIP-Seq_HEK293_Human1.55511398
44TET1_21451524_ChIP-Seq_MESCs_Mouse1.54800430
45SOX2_27498859_Chip-Seq_STOMACH_Mouse1.53202900
46MYC_22102868_ChIP-Seq_BL_Human1.49294662
47KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.46880100
48FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.45668453
49KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.43276711
50JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.40200519
51E2F1_18555785_ChIP-Seq_MESCs_Mouse1.40051543
52SRY_22984422_ChIP-ChIP_TESTIS_Rat1.39519754
53THAP11_20581084_ChIP-Seq_MESCs_Mouse1.37193884
54HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.37125767
55TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.36993837
56HNF4A_19822575_ChIP-Seq_HepG2_Human1.35173828
57KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.34751112
58KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.34751112
59KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.34751112
60FOXA2_19822575_ChIP-Seq_HepG2_Human1.34591196
61DCP1A_22483619_ChIP-Seq_HELA_Human1.33867562
62NELFA_20434984_ChIP-Seq_ESCs_Mouse1.32175950
63HTT_18923047_ChIP-ChIP_STHdh_Human1.32012756
64CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31990003
65ELF1_17652178_ChIP-ChIP_JURKAT_Human1.30749481
66KAP1_22055183_ChIP-Seq_ESCs_Mouse1.29692037
67UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.29627223
68SALL4_18804426_ChIP-ChIP_XEN_Mouse1.27203246
69NANOG_18555785_ChIP-Seq_MESCs_Mouse1.26874814
70POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.26073820
71KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.26073635
72BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.24717595
73ETS1_20019798_ChIP-Seq_JURKAT_Human1.24366120
74CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.22181064
75TTF2_22483619_ChIP-Seq_HELA_Human1.18601282
76ELF1_20517297_ChIP-Seq_JURKAT_Human1.18043336
77KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.16851743
78PPAR_26484153_Chip-Seq_NCI-H1993_Human1.14383225
79P68_20966046_ChIP-Seq_HELA_Human1.13973768
80STAT6_21828071_ChIP-Seq_BEAS2B_Human1.13511840
81TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11569744
82GATA3_24758297_ChIP-Seq_MCF-7_Human1.11100449
83ESR1_20079471_ChIP-ChIP_T-47D_Human1.09053678
84SOX2_20726797_ChIP-Seq_SW620_Human1.08894538
85NCOR1_26117541_ChIP-Seq_K562_Human1.08750950
86TCF7_22412390_ChIP-Seq_EML_Mouse1.08673392
87RXRA_24833708_ChIP-Seq_LIVER_Mouse1.07663385
88SA1_27219007_Chip-Seq_ERYTHROID_Human1.07407473
89P63_26484246_Chip-Seq_KERATINOCYTES_Human1.06914129
90RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.05711525
91RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.05277392
92CTCF_18555785_ChIP-Seq_MESCs_Mouse1.05140023
93THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.04931947
94TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.04629564
95GABP_19822575_ChIP-Seq_HepG2_Human1.04049377
96NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.03157333
97CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.03111947
98ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.03104467
99UBF1/2_26484160_Chip-Seq_HMECs_Human1.02812012
100CTCF_27219007_Chip-Seq_ERYTHROID_Human1.02671374
101SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.02436534
102GATA6_25053715_ChIP-Seq_YYC3_Human1.01973968
103NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.00410462
104ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.99782564
105MYCN_18555785_ChIP-Seq_MESCs_Mouse0.99680342
106TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.99650102
107P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99124206
108PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.98635717
109HIF1A_21447827_ChIP-Seq_MCF-7_Human0.97533937
110Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.95335442
111SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.95050454
112KDM2B_26808549_Chip-Seq_SUP-B15_Human0.92591757
113TP63_19390658_ChIP-ChIP_HaCaT_Human0.92489567
114PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.92148606
115CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.91803785
116SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.91437823
117CTCF_21964334_Chip-Seq_Bcells_Human0.91344884
118FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.91290783
119CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90953124
120GATA1_22383799_ChIP-Seq_G1ME_Mouse0.90866437
121NFE2_27457419_Chip-Seq_LIVER_Mouse0.90722067
122ESR1_15608294_ChIP-ChIP_MCF-7_Human0.90553320
123SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.90455953
124CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.90378146
125STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.89231764
126SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.89201370
127SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.89201370
128BCL6_27268052_Chip-Seq_Bcells_Human0.88724360
129CLOCK_20551151_ChIP-Seq_293T_Human0.86728733
130NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.85289838
131ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84876098
132SUZ12_27294783_Chip-Seq_NPCs_Mouse0.80929361
133ERG_21242973_ChIP-ChIP_JURKAT_Human0.79361299
134EGR1_19032775_ChIP-ChIP_M12_Human0.79347986
135STAT3_1855785_ChIP-Seq_MESCs_Mouse0.78878269
136CDX2_19796622_ChIP-Seq_MESCs_Mouse0.78070377
137RAD21_21589869_ChIP-Seq_MESCs_Mouse0.75664407
138CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.75552100
139FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.74838015
140STAT1_17558387_ChIP-Seq_HELA_Human0.74245969
141RACK7_27058665_Chip-Seq_MCF-7_Human0.73713668
142ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.73396508
143RARA_24833708_ChIP-Seq_LIVER_Mouse0.73263070
144FOXO3_23340844_ChIP-Seq_DLD1_Human0.73181268
145AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.72848982
146GATA2_21666600_ChIP-Seq_HMVEC_Human0.72174433
147GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.69156446
148HNFA_21074721_ChIP-Seq_CACO-2_Human0.67120630
149EZH2_27294783_Chip-Seq_NPCs_Mouse0.66910045
150TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.66629938
151ZNF217_24962896_ChIP-Seq_MCF-7_Human0.66440701
152GATA1_22025678_ChIP-Seq_K562_Human0.66294281
153SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.65532285
154IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.63345212
155KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.62109469
156IRF8_22096565_ChIP-ChIP_GC-B_Human0.62058864
157CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.61925862
158STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.61595336
159CDX2_22108803_ChIP-Seq_LS180_Human0.60876557
160SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.60762200
161SOX9_24532713_ChIP-Seq_HFSC_Mouse0.60719015
162FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.60079024
163GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.60062269
164AR_21909140_ChIP-Seq_LNCAP_Human0.59973868
165CSB_26484114_Chip-Seq_FIBROBLAST_Human0.59872956
166KAP1_27257070_Chip-Seq_ESCs_Mouse0.59390745
167SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.56709029
168CJUN_26792858_Chip-Seq_BT549_Human0.56667220
169SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.56095891
170PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.55588465
171ESET_19884257_ChIP-Seq_ESCs_Mouse0.55089478
172PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.54813301
173CBP_21632823_ChIP-Seq_H3396_Human0.54556761
174TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.53972910

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.47426079
2MP0005085_abnormal_gallbladder_physiolo5.52981037
3MP0005365_abnormal_bile_salt5.29541112
4MP0005360_urolithiasis4.98935205
5MP0005083_abnormal_biliary_tract3.86857016
6MP0003252_abnormal_bile_duct3.25927953
7MP0008875_abnormal_xenobiotic_pharmacok3.18984744
8MP0009840_abnormal_foam_cell3.04459650
9MP0001666_abnormal_nutrient_absorption3.01240189
10MP0002138_abnormal_hepatobiliary_system2.95916849
11MP0003878_abnormal_ear_physiology2.82765505
12MP0005377_hearing/vestibular/ear_phenot2.82765505
13MP0010329_abnormal_lipoprotein_level2.76529263
14MP0002234_abnormal_pharynx_morphology2.74963222
15MP0004019_abnormal_vitamin_homeostasis2.62219660
16MP0008004_abnormal_stomach_pH2.39057160
17MP0002254_reproductive_system_inflammat2.35056171
18MP0003806_abnormal_nucleotide_metabolis2.31545022
19MP0009697_abnormal_copulation2.28985999
20MP0003195_calcinosis2.22777326
21MP0005332_abnormal_amino_acid2.16428657
22MP0002877_abnormal_melanocyte_morpholog2.14088646
23MP0004272_abnormal_basement_membrane2.01678621
24MP0003693_abnormal_embryo_hatching2.00690328
25MP0001849_ear_inflammation1.99304421
26MP0004957_abnormal_blastocyst_morpholog1.94619865
27MP0005464_abnormal_platelet_physiology1.93317367
28MP0003191_abnormal_cellular_cholesterol1.91044468
29MP0010352_gastrointestinal_tract_polyps1.86257955
30MP0003868_abnormal_feces_composition1.85372892
31MP0000566_synostosis1.85054599
32MP0004808_abnormal_hematopoietic_stem1.77297564
33MP0003011_delayed_dark_adaptation1.74491943
34MP0003111_abnormal_nucleus_morphology1.71314718
35MP0002796_impaired_skin_barrier1.69829954
36MP0000609_abnormal_liver_physiology1.66444159
37MP0009379_abnormal_foot_pigmentation1.66209064
38MP0002098_abnormal_vibrissa_morphology1.63490668
39MP0003941_abnormal_skin_development1.61373002
40MP0005084_abnormal_gallbladder_morpholo1.58961994
41MP0008932_abnormal_embryonic_tissue1.57613157
42MP0004782_abnormal_surfactant_physiolog1.57492770
43MP0005451_abnormal_body_composition1.51736332
44MP0001764_abnormal_homeostasis1.48280474
45MP0000003_abnormal_adipose_tissue1.48089777
46MP0002118_abnormal_lipid_homeostasis1.46385193
47MP0005023_abnormal_wound_healing1.45094511
48MP0005319_abnormal_enzyme/_coenzyme1.40867988
49MP0001730_embryonic_growth_arrest1.40862273
50MP0002160_abnormal_reproductive_system1.40733452
51MP0004381_abnormal_hair_follicle1.40697748
52MP0009333_abnormal_splenocyte_physiolog1.39801321
53MP0004185_abnormal_adipocyte_glucose1.38606340
54MP0009764_decreased_sensitivity_to1.31659491
55MP0003077_abnormal_cell_cycle1.31285349
56MP0005623_abnormal_meninges_morphology1.28121828
57MP0005248_abnormal_Harderian_gland1.27787147
58MP0010094_abnormal_chromosome_stability1.26265178
59MP0005409_darkened_coat_color1.22768146
60MP0005076_abnormal_cell_differentiation1.22674543
61MP0003315_abnormal_perineum_morphology1.21475405
62MP0004510_myositis1.21188012
63MP0003186_abnormal_redox_activity1.19342174
64MP0003718_maternal_effect1.19271695
65MP0001545_abnormal_hematopoietic_system1.18747621
66MP0005397_hematopoietic_system_phenotyp1.18747621
67MP0005220_abnormal_exocrine_pancreas1.16955843
68MP0004858_abnormal_nervous_system1.16057913
69MP0000579_abnormal_nail_morphology1.12931623
70MP0000350_abnormal_cell_proliferation1.12438584
71MP0000733_abnormal_muscle_development1.11920177
72MP0000858_altered_metastatic_potential1.09030090
73MP0005647_abnormal_sex_gland1.08945558
74MP0004233_abnormal_muscle_weight1.08317020
75MP0004264_abnormal_extraembryonic_tissu1.08236790
76MP0010771_integument_phenotype1.06702157
77MP0005058_abnormal_lysosome_morphology1.05465623
78MP0009643_abnormal_urine_homeostasis1.04367637
79MP0001346_abnormal_lacrimal_gland1.03799904
80MP0003705_abnormal_hypodermis_morpholog1.03304362
81MP0002086_abnormal_extraembryonic_tissu1.03178592
82MP0001348_abnormal_lacrimal_gland1.02274725
83MP0004947_skin_inflammation1.01742148
84MP0000681_abnormal_thyroid_gland0.99945745
85MP0005375_adipose_tissue_phenotype0.99610584
86MP0002089_abnormal_postnatal_growth/wei0.98241620
87MP0002080_prenatal_lethality0.96689346
88MP0001672_abnormal_embryogenesis/_devel0.95975504
89MP0005380_embryogenesis_phenotype0.95975504
90MP0001697_abnormal_embryo_size0.95159667
91MP0003453_abnormal_keratinocyte_physiol0.92920320
92MP0009931_abnormal_skin_appearance0.92158260
93MP0005395_other_phenotype0.91276024
94MP0000383_abnormal_hair_follicle0.90356777
95MP0005501_abnormal_skin_physiology0.89883906
96MP0003943_abnormal_hepatobiliary_system0.89546250
97MP0002697_abnormal_eye_size0.89535961
98MP0001879_abnormal_lymphatic_vessel0.89485263
99MP0003984_embryonic_growth_retardation0.88936144
100MP0008260_abnormal_autophagy0.88843378
101MP0000358_abnormal_cell_content/0.88068250
102MP0005666_abnormal_adipose_tissue0.85907006
103MP0002928_abnormal_bile_duct0.84843827
104MP0003879_abnormal_hair_cell0.84080374
105MP0000598_abnormal_liver_morphology0.83180569
106MP0003786_premature_aging0.82962390
107MP0000049_abnormal_middle_ear0.82902224
108MP0010678_abnormal_skin_adnexa0.80717146
109MP0009053_abnormal_anal_canal0.80557728
110MP0002088_abnormal_embryonic_growth/wei0.80341889
111MP0010368_abnormal_lymphatic_system0.78956663
112MP0003950_abnormal_plasma_membrane0.78441925
113MP0000313_abnormal_cell_death0.77196482
114MP0006138_congestive_heart_failure0.76984026
115MP0002132_abnormal_respiratory_system0.76637381
116MP0005408_hypopigmentation0.75523316
117MP0000678_abnormal_parathyroid_gland0.74761624
118MP0002060_abnormal_skin_morphology0.74416155
119MP0000647_abnormal_sebaceous_gland0.73786486
120MP0002084_abnormal_developmental_patter0.73593802
121MP0002168_other_aberrant_phenotype0.72542322
122MP0001881_abnormal_mammary_gland0.72474397
123MP0001324_abnormal_eye_pigmentation0.72070793
124MP0005670_abnormal_white_adipose0.71960901
125MP0000613_abnormal_salivary_gland0.70751469
126MP0002876_abnormal_thyroid_physiology0.70583433
127MP0000627_abnormal_mammary_gland0.69294346
128MP0000762_abnormal_tongue_morphology0.68813064
129MP0010030_abnormal_orbit_morphology0.68233567
130MP0000427_abnormal_hair_cycle0.68028366
131MP0010234_abnormal_vibrissa_follicle0.68018885
132MP0003566_abnormal_cell_adhesion0.65750531
133MP0001756_abnormal_urination0.65698020
134MP0000377_abnormal_hair_follicle0.64367261
135MP0001216_abnormal_epidermal_layer0.61039905
136MP0003656_abnormal_erythrocyte_physiolo0.60790268
137MP0005636_abnormal_mineral_homeostasis0.60488205
138MP0005584_abnormal_enzyme/coenzyme_acti0.60224358
139MP0002136_abnormal_kidney_physiology0.58853106
140MP0005167_abnormal_blood-brain_barrier0.58601172
141MP0009763_increased_sensitivity_to0.58254532
142MP0009642_abnormal_blood_homeostasis0.50705442
143MP0001542_abnormal_bone_strength0.50250369
144MP0003638_abnormal_response/metabolism_0.49620366
145MP0009384_cardiac_valve_regurgitation0.49248936
146MP0001661_extended_life_span0.48847203
147MP0008469_abnormal_protein_level0.47851548
148MP0002249_abnormal_larynx_morphology0.47166566
149MP0000470_abnormal_stomach_morphology0.47033250
150MP0002127_abnormal_cardiovascular_syste0.43743437
151MP0009765_abnormal_xenobiotic_induced0.43052801
152MP0003936_abnormal_reproductive_system0.42581594
153MP0000538_abnormal_urinary_bladder0.41463712
154MP0001286_abnormal_eye_development0.38912407
155MP0001664_abnormal_digestion0.36127074
156MP0000467_abnormal_esophagus_morphology0.35959171
157MP0000537_abnormal_urethra_morphology0.35309580
158MP0001119_abnormal_female_reproductive0.34869682
159MP0005376_homeostasis/metabolism_phenot0.34447988

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)5.62730160
2Abnormality of aromatic amino acid family metabolism (HP:0004338)5.55308882
3Abnormality of monocarboxylic acid metabolism (HP:0010996)5.33612539
4Alopecia of scalp (HP:0002293)5.29164502
5Deep venous thrombosis (HP:0002625)5.08038477
6Prolonged partial thromboplastin time (HP:0003645)5.02563600
7Xanthomatosis (HP:0000991)4.82754306
8Hyperglycinemia (HP:0002154)4.54302719
9Hyperlipoproteinemia (HP:0010980)4.36765271
10Hypobetalipoproteinemia (HP:0003563)4.10553894
11Fat malabsorption (HP:0002630)3.85995421
12Joint hemorrhage (HP:0005261)3.85262953
13Hypoalphalipoproteinemia (HP:0003233)3.82903536
14Hyperglycinuria (HP:0003108)3.78702022
15Hyperammonemia (HP:0001987)3.76282879
16Abnormality of glycine metabolism (HP:0010895)3.70202993
17Abnormality of serine family amino acid metabolism (HP:0010894)3.70202993
18Hypolipoproteinemia (HP:0010981)3.69892102
19Unilateral renal agenesis (HP:0000122)3.69792367
20Parakeratosis (HP:0001036)3.66689518
21Popliteal pterygium (HP:0009756)3.55591638
22Abnormality of glutamine family amino acid metabolism (HP:0010902)3.50431077
23Abnormality of pyrimidine metabolism (HP:0004353)3.44018656
24Conjugated hyperbilirubinemia (HP:0002908)3.40300047
25Complement deficiency (HP:0004431)3.39994841
26Steatorrhea (HP:0002570)3.36132006
27Hypoglycemic coma (HP:0001325)3.33045618
28Vascular calcification (HP:0004934)3.29199272
29Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.25179296
30Bilateral sensorineural hearing impairment (HP:0008619)3.21848756
31Abnormality of the common coagulation pathway (HP:0010990)3.20612671
32Increased mean platelet volume (HP:0011877)3.19577478
33Abnormality of methionine metabolism (HP:0010901)3.17832939
34Abnormality of sulfur amino acid metabolism (HP:0004339)3.17312817
35Fragile nails (HP:0001808)3.16030186
36Esophageal varix (HP:0002040)3.15111319
37Truncus arteriosus (HP:0001660)3.14827104
38Gout (HP:0001997)3.11304084
39Poikiloderma (HP:0001029)3.09245320
40Pterygium (HP:0001059)3.07173305
41Abnormality of the intrinsic pathway (HP:0010989)3.04316850
42Selective tooth agenesis (HP:0001592)3.02486343
43Milia (HP:0001056)2.99601267
44Epidermoid cyst (HP:0200040)2.99460114
45Ketosis (HP:0001946)2.96155066
46Cheilitis (HP:0100825)2.95214660
47Abnormality of serum amino acid levels (HP:0003112)2.92193982
48Abnormality of aspartate family amino acid metabolism (HP:0010899)2.91895247
49Right ventricular cardiomyopathy (HP:0011663)2.91845666
50Double outlet right ventricle (HP:0001719)2.90326216
51Congenital malformation of the right heart (HP:0011723)2.90326216
52Cardiovascular calcification (HP:0011915)2.83943931
53Acute lymphatic leukemia (HP:0006721)2.77420998
54Abnormal platelet volume (HP:0011876)2.77224995
55Abnormality of nucleobase metabolism (HP:0010932)2.75773987
56Absent eyelashes (HP:0000561)2.73573571
57Abnormality of fatty-acid metabolism (HP:0004359)2.71471881
58Abnormality of placental membranes (HP:0011409)2.70903897
59Amniotic constriction ring (HP:0009775)2.70903897
60Myocardial infarction (HP:0001658)2.64135329
61Nail dystrophy (HP:0008404)2.61940475
62Follicular hyperkeratosis (HP:0007502)2.57957625
63Hepatocellular carcinoma (HP:0001402)2.56946483
64Abnormality of complement system (HP:0005339)2.55690594
65Hypercholesterolemia (HP:0003124)2.53685019
66Hyperthyroidism (HP:0000836)2.52206200
67Impaired platelet aggregation (HP:0003540)2.50042685
68Abnormal platelet function (HP:0011869)2.50042685
69Entropion (HP:0000621)2.49660112
70Severe visual impairment (HP:0001141)2.46643954
71Short nail (HP:0001799)2.44000862
72Flat acetabular roof (HP:0003180)2.43985241
73Abnormality of the Achilles tendon (HP:0005109)2.42974233
74Atrophic scars (HP:0001075)2.42358652
75Abnormality of dicarboxylic acid metabolism (HP:0010995)2.41765313
76Dicarboxylic aciduria (HP:0003215)2.41765313
77Abnormality of purine metabolism (HP:0004352)2.41651653
78Ankyloglossia (HP:0010296)2.41224669
79Rickets (HP:0002748)2.40735997
80Preauricular pit (HP:0004467)2.38756669
81Periauricular skin pits (HP:0100277)2.38756669
82Squamous cell carcinoma (HP:0002860)2.35303360
83Abolished electroretinogram (ERG) (HP:0000550)2.34663487
84Hypoglycemic seizures (HP:0002173)2.34272586
85Abnormality of the distal phalanges of the toes (HP:0010182)2.34157945
86Fragile skin (HP:0001030)2.33973832
87Trismus (HP:0000211)2.33777645
88Renal cortical cysts (HP:0000803)2.33175012
89Reticulocytopenia (HP:0001896)2.32063795
90Recurrent corneal erosions (HP:0000495)2.29101997
91Abnormality of cells of the erythroid lineage (HP:0012130)2.28726956
92Hypochromic microcytic anemia (HP:0004840)2.27382891
93Abnormality of nail color (HP:0100643)2.27125032
94Lethargy (HP:0001254)2.27075956
95Sparse eyelashes (HP:0000653)2.23183014
96Abnormality of dental color (HP:0011073)2.21691811
97Neonatal death (HP:0003811)2.21427928
98Abnormality of carpal bone ossification (HP:0006257)2.21257124
99Pigmentary retinal degeneration (HP:0001146)2.20864669
100Erythroderma (HP:0001019)2.20691569
101Delayed CNS myelination (HP:0002188)2.20632811
102Purpura (HP:0000979)2.20389807
103Achilles tendon contracture (HP:0001771)2.19878959
104Ridged nail (HP:0001807)2.19421896
105Focal segmental glomerulosclerosis (HP:0000097)2.18197189
106Reduced subcutaneous adipose tissue (HP:0003758)2.16620939
107Hypoplasia of the uterus (HP:0000013)2.15732928
108Hydroxyprolinuria (HP:0003080)2.13023127
109Abnormality of proline metabolism (HP:0010907)2.13023127
110Progressive muscle weakness (HP:0003323)2.12952101
111Prolonged bleeding time (HP:0003010)2.12795519
112Mitral stenosis (HP:0001718)2.12660356
113Polygenic inheritance (HP:0010982)2.10498517
114Hyperbilirubinemia (HP:0002904)2.09631014
115Proximal tubulopathy (HP:0000114)2.08985369
116Glomerulosclerosis (HP:0000096)2.08832308
117Abnormality of the umbilical cord (HP:0010881)2.07727263
118Pustule (HP:0200039)2.07238573
119Abnormalities of placenta or umbilical cord (HP:0001194)2.03316183
120Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.03182581
121Onycholysis (HP:0001806)2.02884165
122Distal lower limb amyotrophy (HP:0008944)2.02382594
123Hypoplastic heart (HP:0001961)2.01738078
124Stridor (HP:0010307)2.01085742
125Abnormal ventriculo-arterial connection (HP:0011563)2.00502770
126Transposition of the great arteries (HP:0001669)2.00502770
127Abnormal connection of the cardiac segments (HP:0011545)2.00502770
128Aplasia/Hypoplasia of the sacrum (HP:0008517)1.99201833
129Menorrhagia (HP:0000132)1.98466311
130Breast hypoplasia (HP:0003187)1.98038031
131Pendular nystagmus (HP:0012043)1.97996090
132Male infertility (HP:0003251)1.97522594
133Chorioretinal atrophy (HP:0000533)1.96993474
134Micronodular cirrhosis (HP:0001413)1.96907954
135Plantar hyperkeratosis (HP:0007556)1.96374569
136Septate vagina (HP:0001153)1.96214188
137Metabolic acidosis (HP:0001942)1.95580082
138Down-sloping shoulders (HP:0200021)1.95448444
139Macrocytic anemia (HP:0001972)1.92924040
140Spontaneous abortion (HP:0005268)1.92613771
141Abnormality of oral frenula (HP:0000190)1.91750720
142Hyperglycemia (HP:0003074)1.90053409
143Vitreoretinal degeneration (HP:0000655)1.88927380
144Thick nail (HP:0001805)1.88618924
145Increased purine levels (HP:0004368)1.86954131
146Hyperuricemia (HP:0002149)1.86954131
147Abnormal number of erythroid precursors (HP:0012131)1.86529659
148Opisthotonus (HP:0002179)1.86251098
149Absent eyebrow (HP:0002223)1.86131405
150Prolonged neonatal jaundice (HP:0006579)1.85993656
151Pancreatitis (HP:0001733)1.84989321
152Abnormal ossification of hand bones (HP:0005921)1.84772653
153Palmoplantar hyperkeratosis (HP:0000972)1.84404173
154Rough bone trabeculation (HP:0100670)1.84193244
155Chronic hepatic failure (HP:0100626)1.83659836
156Deviation of the thumb (HP:0009603)1.82467534
157Gingival bleeding (HP:0000225)1.82181559
158Hypergonadotropic hypogonadism (HP:0000815)1.81539674
159Hypoplastic left heart (HP:0004383)1.81090022
160Ureteral duplication (HP:0000073)1.80072321
161Respiratory distress (HP:0002098)1.79291846
162Skin pits (HP:0100276)1.79180597
163Systemic lupus erythematosus (HP:0002725)1.79100738
164Hemorrhage of the eye (HP:0011885)1.78204913
165Ketoacidosis (HP:0001993)1.77401600
166Corneal erosion (HP:0200020)1.77343391
167Bile duct proliferation (HP:0001408)1.76179852
168Abnormal biliary tract physiology (HP:0012439)1.76179852
169Oligodontia (HP:0000677)1.75174901
170Lip pit (HP:0100267)1.75096556
171Petechiae (HP:0000967)1.75034670
172Abnormality of the tricuspid valve (HP:0001702)1.73845270
173Palmar hyperkeratosis (HP:0010765)1.73677639
174Abnormal blistering of the skin (HP:0008066)1.73650466
175Elevated alkaline phosphatase (HP:0003155)1.73107112
176Hyperphosphatemia (HP:0002905)1.72832924
177Hypoparathyroidism (HP:0000829)1.72573340
178Back pain (HP:0003418)1.72432671
179Elbow flexion contracture (HP:0002987)1.71981516
180Generalized aminoaciduria (HP:0002909)1.71778306
181Congenital sensorineural hearing impairment (HP:0008527)1.71610127
182Ectropion (HP:0000656)1.69922754

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA28.60905125
2SMG15.06588033
3SIK14.42179932
4BCKDK3.64924740
5STK38L3.31896182
6VRK23.27879042
7SIK33.18577431
8IRAK32.65860722
9ZAK2.47281370
10TAF12.34521019
11LATS12.30032070
12TRIB32.16282043
13ICK2.06954376
14INSRR2.05472385
15AKT31.85221490
16FGFR41.84440811
17AURKA1.76048632
18MST1R1.75407700
19ERN11.65304751
20PIK3CG1.64884031
21GRK11.61925312
22MAP2K21.57043590
23ARAF1.53423150
24CDK121.53319819
25PRKD31.52120621
26TIE11.31531709
27CHEK21.30242745
28PAK41.26110904
29FRK1.25714867
30MARK31.22044880
31STK31.20166191
32ERBB41.19227137
33FER1.15163091
34ILK1.14274064
35RPS6KB21.13841789
36NME21.13397012
37KDR1.12553435
38DDR21.11219572
39MAP3K141.09038964
40DAPK11.06734296
41STK101.06493222
42NEK91.01817678
43TESK10.99467733
44PDGFRA0.98410081
45MELK0.97537771
46RPS6KA40.95760437
47MAP3K90.95741527
48TAOK30.91121930
49PINK10.90567784
50BRSK10.90188425
51BRAF0.89469044
52CDK90.89258045
53MOS0.88093524
54STK380.87681822
55MAPK110.86320683
56MAP3K80.84654600
57STK240.83460714
58MAP3K30.82750528
59EPHB20.81999893
60SIK20.81619805
61PIM20.80849567
62PTK60.80784147
63FLT30.79484673
64TTK0.79337428
65LRRK20.77522605
66BUB10.76369822
67DAPK30.75632016
68PLK40.74281297
69PTK20.73482914
70IRAK20.73022674
71HIPK20.72771292
72AURKB0.71435713
73STK160.67754764
74ERBB20.67236650
75TTN0.65565275
76GRK50.64240557
77PBK0.62989356
78MET0.62718288
79CHUK0.61701071
80MAP3K110.61428004
81EIF2AK20.60992851
82MAPK150.60328886
83BMPR1B0.60219561
84TYK20.60003797
85MTOR0.58876963
86CAMK2G0.58633781
87NLK0.58475552
88MAP2K30.57234848
89VRK10.56844230
90CDK70.53016527
91PDPK10.52397741
92PRKAA10.52184762
93LATS20.52151977
94EIF2AK30.52041753
95TAOK20.51933668
96CSK0.51522669
97PRKAA20.50704522
98CDK80.50704031
99CDK190.50052543
100NME10.49033376
101MAP2K10.47600452
102CDC70.46944065
103ABL20.46935988
104TGFBR20.46916859
105IKBKB0.46002349
106NUAK10.44648615
107DAPK20.44483845
108PAK10.44357115
109CDK60.43718114
110* CHEK10.43597854
111GSK3A0.43388870
112EEF2K0.43160327
113DYRK1B0.41415397
114PRKG20.41411691
115IRAK10.41012722
116MST40.41000859
117NTRK10.40710453
118MAP3K50.40485794
119ADRBK20.39533107
120MAP3K10.39332009
121BMX0.39070122
122EIF2AK10.36837415
123PLK10.36718206
124PIM10.36298084
125NEK10.35870821
126CSNK1A1L0.34763078
127ZAP700.34252529
128TESK20.34245268
129AKT20.34193234
130TBK10.33833301
131PRPF4B0.33574200
132LMTK20.33003073
133MAP3K60.32455934
134MAPK70.32018639
135CSNK1G30.31914472
136RIPK10.31741056
137NEK20.31422989
138PRKCE0.31200973
139MAPKAPK50.31157464
140WEE10.30119243
141CDK40.29949263
142STK40.29675667
143MAPK120.29477370
144SGK20.28518073
145RPS6KL10.27226337
146RPS6KC10.27226337
147IRAK40.26998552
148PRKCD0.26624373
149PIK3CA0.26476899
150MAP3K20.26158033
151PKN20.24949165
152MAP2K60.23765535
153PRKCI0.23634463
154RPS6KA60.23592829

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.97483346
2Ribosome_Homo sapiens_hsa030103.66510358
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.34014686
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.04908206
5Arginine biosynthesis_Homo sapiens_hsa002202.94209916
6Complement and coagulation cascades_Homo sapiens_hsa046102.48011610
7Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.47160932
8Pentose and glucuronate interconversions_Homo sapiens_hsa000402.46817231
9Tryptophan metabolism_Homo sapiens_hsa003802.42950630
10DNA replication_Homo sapiens_hsa030302.40864565
11Nitrogen metabolism_Homo sapiens_hsa009102.31368384
12Fatty acid degradation_Homo sapiens_hsa000712.22412054
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.17685453
14Steroid hormone biosynthesis_Homo sapiens_hsa001402.17619450
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.15706845
16Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.11861456
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.11161370
18Folate biosynthesis_Homo sapiens_hsa007902.09980277
19Chemical carcinogenesis_Homo sapiens_hsa052042.09939170
20Retinol metabolism_Homo sapiens_hsa008302.04377321
21beta-Alanine metabolism_Homo sapiens_hsa004102.04128329
22Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.98708134
23Histidine metabolism_Homo sapiens_hsa003401.98102325
24Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.92573039
25Peroxisome_Homo sapiens_hsa041461.88131964
26Mismatch repair_Homo sapiens_hsa034301.84777355
27Vitamin digestion and absorption_Homo sapiens_hsa049771.83033705
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.74180817
29Propanoate metabolism_Homo sapiens_hsa006401.69733961
30Vitamin B6 metabolism_Homo sapiens_hsa007501.68595486
31Renin-angiotensin system_Homo sapiens_hsa046141.64245863
32Phenylalanine metabolism_Homo sapiens_hsa003601.63607981
33Pyrimidine metabolism_Homo sapiens_hsa002401.60205701
34Bladder cancer_Homo sapiens_hsa052191.57858284
35Fatty acid metabolism_Homo sapiens_hsa012121.56359291
36Fat digestion and absorption_Homo sapiens_hsa049751.56059304
37PPAR signaling pathway_Homo sapiens_hsa033201.55503699
38Butanoate metabolism_Homo sapiens_hsa006501.50752395
39Maturity onset diabetes of the young_Homo sapiens_hsa049501.47972247
40Arginine and proline metabolism_Homo sapiens_hsa003301.47677926
41Base excision repair_Homo sapiens_hsa034101.47641563
42Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.46509866
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44660111
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.44469910
45Nucleotide excision repair_Homo sapiens_hsa034201.44346095
46Thyroid cancer_Homo sapiens_hsa052161.43562426
47Selenocompound metabolism_Homo sapiens_hsa004501.43509848
48Staphylococcus aureus infection_Homo sapiens_hsa051501.42644549
49Chronic myeloid leukemia_Homo sapiens_hsa052201.38867972
50Starch and sucrose metabolism_Homo sapiens_hsa005001.37444940
51Steroid biosynthesis_Homo sapiens_hsa001001.36755905
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.35972420
53Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.32850093
54Tyrosine metabolism_Homo sapiens_hsa003501.31291399
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.25565973
56Cell cycle_Homo sapiens_hsa041101.25482445
57Cysteine and methionine metabolism_Homo sapiens_hsa002701.23723133
58Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.22276052
59Central carbon metabolism in cancer_Homo sapiens_hsa052301.21385384
60Sulfur relay system_Homo sapiens_hsa041221.20770075
61Homologous recombination_Homo sapiens_hsa034401.19499600
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.19209927
63p53 signaling pathway_Homo sapiens_hsa041151.15744849
64Fatty acid elongation_Homo sapiens_hsa000621.14769979
65Bile secretion_Homo sapiens_hsa049761.14529203
66One carbon pool by folate_Homo sapiens_hsa006701.12454631
67ABC transporters_Homo sapiens_hsa020101.10205018
68Biosynthesis of amino acids_Homo sapiens_hsa012301.09575039
69Cyanoamino acid metabolism_Homo sapiens_hsa004601.05783691
70Sulfur metabolism_Homo sapiens_hsa009201.00065075
71Caffeine metabolism_Homo sapiens_hsa002320.97688571
72Lysine degradation_Homo sapiens_hsa003100.95274030
73RNA transport_Homo sapiens_hsa030130.94446732
74Carbon metabolism_Homo sapiens_hsa012000.88686054
75Notch signaling pathway_Homo sapiens_hsa043300.87836768
76Pancreatic cancer_Homo sapiens_hsa052120.85582821
77Glycerolipid metabolism_Homo sapiens_hsa005610.84123103
78Glutathione metabolism_Homo sapiens_hsa004800.83959932
79Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.83831004
80Pentose phosphate pathway_Homo sapiens_hsa000300.82224189
81N-Glycan biosynthesis_Homo sapiens_hsa005100.79640035
82Pyruvate metabolism_Homo sapiens_hsa006200.77190376
83Glycosaminoglycan degradation_Homo sapiens_hsa005310.74284924
84Fructose and mannose metabolism_Homo sapiens_hsa000510.74092826
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73395913
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.71957794
87Spliceosome_Homo sapiens_hsa030400.71401196
88Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.68679427
89alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64654315
90Focal adhesion_Homo sapiens_hsa045100.63896005
91Sphingolipid metabolism_Homo sapiens_hsa006000.60881952
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59324170
93Insulin signaling pathway_Homo sapiens_hsa049100.59042971
94Mineral absorption_Homo sapiens_hsa049780.58774582
95Linoleic acid metabolism_Homo sapiens_hsa005910.56239109
96Metabolic pathways_Homo sapiens_hsa011000.55879857
97Amoebiasis_Homo sapiens_hsa051460.54399738
98Non-small cell lung cancer_Homo sapiens_hsa052230.54049515
99Regulation of autophagy_Homo sapiens_hsa041400.53598580
100Proteoglycans in cancer_Homo sapiens_hsa052050.51140429
101Melanoma_Homo sapiens_hsa052180.49112559
102Galactose metabolism_Homo sapiens_hsa000520.48427749
103Fanconi anemia pathway_Homo sapiens_hsa034600.47075979
104Fatty acid biosynthesis_Homo sapiens_hsa000610.46377259
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.45957373
106Acute myeloid leukemia_Homo sapiens_hsa052210.45074283
107Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42585499
108Arachidonic acid metabolism_Homo sapiens_hsa005900.41555771
109Prion diseases_Homo sapiens_hsa050200.39995171
110MicroRNAs in cancer_Homo sapiens_hsa052060.39417787
111AMPK signaling pathway_Homo sapiens_hsa041520.38700460
112Protein digestion and absorption_Homo sapiens_hsa049740.38492568
113Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.37607306
114Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.37004119
115Purine metabolism_Homo sapiens_hsa002300.34139804
116Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31907708
117PI3K-Akt signaling pathway_Homo sapiens_hsa041510.31872500
118Neurotrophin signaling pathway_Homo sapiens_hsa047220.30092954
119Pathways in cancer_Homo sapiens_hsa052000.29994613
120Platelet activation_Homo sapiens_hsa046110.29832453
121Circadian rhythm_Homo sapiens_hsa047100.23431013
122ECM-receptor interaction_Homo sapiens_hsa045120.21794868
123Adherens junction_Homo sapiens_hsa045200.14244544
124Insulin resistance_Homo sapiens_hsa049310.12481843
125Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.11624558
126Small cell lung cancer_Homo sapiens_hsa052220.10381586
127Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.08801842
128Pancreatic secretion_Homo sapiens_hsa049720.06408682
129Ovarian steroidogenesis_Homo sapiens_hsa049130.06320294
130Legionellosis_Homo sapiens_hsa051340.03706383
131Hippo signaling pathway_Homo sapiens_hsa043900.03380305
132Hepatitis C_Homo sapiens_hsa051600.02492568
133Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.01442480
134Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.01298261
135African trypanosomiasis_Homo sapiens_hsa05143-0.0708591
136Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623-0.0547595
137Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0525701
138Adipocytokine signaling pathway_Homo sapiens_hsa04920-0.0451679
139Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0402020
140Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.0321864
141Basal cell carcinoma_Homo sapiens_hsa05217-0.0318698
142Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060-0.0288845
143Tight junction_Homo sapiens_hsa04530-0.0197493
144Toll-like receptor signaling pathway_Homo sapiens_hsa04620-0.0034725

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