PROX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the homeobox transcription factor family. Members of this family contain a homeobox domain that consists of a 60-amino acid helix-turn-helix structure that binds DNA and RNA. The protein encoded by this gene is conserved across vertebrates and may play an essential role during development. Altered levels of this protein have been reported in cancers of different organs, such as colon, brain, blood, breast, pancreas, liver and esophagus. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.84932240
2L-phenylalanine catabolic process (GO:0006559)5.84932240
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.32613051
4L-phenylalanine metabolic process (GO:0006558)5.32613051
5exogenous drug catabolic process (GO:0042738)4.78861482
6aromatic amino acid family catabolic process (GO:0009074)4.70914765
7blood coagulation, intrinsic pathway (GO:0007597)4.59885163
8epoxygenase P450 pathway (GO:0019373)4.29143961
9intestinal cholesterol absorption (GO:0030299)4.22103320
10low-density lipoprotein particle remodeling (GO:0034374)4.17796468
11bile acid biosynthetic process (GO:0006699)4.01723102
12omega-hydroxylase P450 pathway (GO:0097267)3.95566605
13* embryonic retina morphogenesis in camera-type eye (GO:0060059)3.82659426
14fibrinolysis (GO:0042730)3.81638941
15triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.78359542
16kynurenine metabolic process (GO:0070189)3.78320947
17indole-containing compound catabolic process (GO:0042436)3.74770929
18indolalkylamine catabolic process (GO:0046218)3.74770929
19tryptophan catabolic process (GO:0006569)3.74770929
20cellular glucuronidation (GO:0052695)3.74299515
21regulation of plasminogen activation (GO:0010755)3.71942534
22glyoxylate metabolic process (GO:0046487)3.64824423
23ethanol oxidation (GO:0006069)3.64442577
24alpha-linolenic acid metabolic process (GO:0036109)3.61808991
25tryptophan metabolic process (GO:0006568)3.55299336
26bile acid metabolic process (GO:0008206)3.51747023
27response to phenylpropanoid (GO:0080184)3.51565827
28high-density lipoprotein particle remodeling (GO:0034375)3.50829561
29glutamate metabolic process (GO:0006536)3.47445622
30fatty acid elongation (GO:0030497)3.46653458
31cellular ketone body metabolic process (GO:0046950)3.46621552
32uronic acid metabolic process (GO:0006063)3.46381171
33glucuronate metabolic process (GO:0019585)3.46381171
34plasma lipoprotein particle organization (GO:0071827)3.45434246
35protein activation cascade (GO:0072376)3.44723058
36coenzyme catabolic process (GO:0009109)3.43645513
37plasma lipoprotein particle assembly (GO:0034377)3.42226276
38dicarboxylic acid biosynthetic process (GO:0043650)3.39086050
39regulation of protein activation cascade (GO:2000257)3.38766864
40regulation of fibrinolysis (GO:0051917)3.35379053
41detection of light stimulus involved in sensory perception (GO:0050962)3.33690863
42detection of light stimulus involved in visual perception (GO:0050908)3.33690863
43tyrosine metabolic process (GO:0006570)3.33341112
44homocysteine metabolic process (GO:0050667)3.32594787
45negative regulation of fibrinolysis (GO:0051918)3.31333317
46axon ensheathment in central nervous system (GO:0032291)3.30866386
47central nervous system myelination (GO:0022010)3.30866386
48complement activation, alternative pathway (GO:0006957)3.29438832
49drug metabolic process (GO:0017144)3.26957688
50aromatic amino acid family metabolic process (GO:0009072)3.26353967
51triglyceride homeostasis (GO:0070328)3.25058385
52acylglycerol homeostasis (GO:0055090)3.25058385
53protein carboxylation (GO:0018214)3.24279719
54peptidyl-glutamic acid carboxylation (GO:0017187)3.24279719
55urea cycle (GO:0000050)3.22965178
56urea metabolic process (GO:0019627)3.22965178
57protein-lipid complex subunit organization (GO:0071825)3.21874524
58negative regulation of blood coagulation (GO:0030195)3.20927017
59negative regulation of hemostasis (GO:1900047)3.20927017
60alpha-amino acid catabolic process (GO:1901606)3.15336601
61regulation of apoptotic cell clearance (GO:2000425)3.14405907
62positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.12639991
63regulation of humoral immune response (GO:0002920)3.11750249
64regulation of complement activation (GO:0030449)3.11221964
65* regulation of bile acid biosynthetic process (GO:0070857)3.11083093
66oxidative demethylation (GO:0070989)3.09242136
67negative regulation of complement activation (GO:0045916)3.06534723
68dicarboxylic acid catabolic process (GO:0043649)3.06326613
69reverse cholesterol transport (GO:0043691)3.06319447
70complement activation, classical pathway (GO:0006958)3.02767418
71cysteine metabolic process (GO:0006534)3.01406182
72protein-lipid complex assembly (GO:0065005)2.99389893
73cholesterol efflux (GO:0033344)2.98725129
74ketone body metabolic process (GO:1902224)2.98290123
75plasma lipoprotein particle remodeling (GO:0034369)2.96053523
76protein-lipid complex remodeling (GO:0034368)2.96053523
77macromolecular complex remodeling (GO:0034367)2.96053523
78nitrogen cycle metabolic process (GO:0071941)2.95559068
79regulation of triglyceride catabolic process (GO:0010896)2.95423391
80short-chain fatty acid metabolic process (GO:0046459)2.94856839
81negative regulation of coagulation (GO:0050819)2.94320446
82aspartate family amino acid catabolic process (GO:0009068)2.94302195
83negative regulation of protein activation cascade (GO:2000258)2.93656315
84negative regulation of wound healing (GO:0061045)2.93119895
85fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.92680220
86acute-phase response (GO:0006953)2.90922775
87plasma lipoprotein particle clearance (GO:0034381)2.89378981
88complement activation (GO:0006956)2.88985966
89lysine catabolic process (GO:0006554)2.88182447
90lysine metabolic process (GO:0006553)2.88182447
91cellular amino acid catabolic process (GO:0009063)2.84913895
92sodium-independent organic anion transport (GO:0043252)2.84731383
93bile acid and bile salt transport (GO:0015721)2.83982122
94regulation of cholesterol esterification (GO:0010872)2.83472323
95negative regulation of lipase activity (GO:0060192)2.83414170
96peptidyl-glutamic acid modification (GO:0018200)2.82824238
97indolalkylamine metabolic process (GO:0006586)2.82121903
98phenylpropanoid metabolic process (GO:0009698)2.81461881
99very long-chain fatty acid metabolic process (GO:0000038)2.80946231
100G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.80409556
101regulation of short-term neuronal synaptic plasticity (GO:0048172)2.75279992
102ethanol metabolic process (GO:0006067)2.74881881
103sulfur amino acid catabolic process (GO:0000098)2.74280269
104amino-acid betaine metabolic process (GO:0006577)2.74184448
105flavonoid metabolic process (GO:0009812)2.73524854
106S-adenosylmethionine metabolic process (GO:0046500)2.72015490
107C4-dicarboxylate transport (GO:0015740)2.70877706
108positive regulation of blood coagulation (GO:0030194)2.69453239
109positive regulation of hemostasis (GO:1900048)2.69453239
110iron coordination entity transport (GO:1901678)2.69011430
111serine family amino acid catabolic process (GO:0009071)2.68990173
112cofactor catabolic process (GO:0051187)2.67422488
113regulation of cholesterol homeostasis (GO:2000188)2.65976751
114heme transport (GO:0015886)2.65382992
115cellular biogenic amine catabolic process (GO:0042402)2.65061750
116amine catabolic process (GO:0009310)2.65061750
117response to mercury ion (GO:0046689)2.63862894
118neurotransmitter-gated ion channel clustering (GO:0072578)2.61025380
119sterol transport (GO:0015918)2.59745822
120cholesterol transport (GO:0030301)2.59745822
121response to methylmercury (GO:0051597)2.59652075
122apical protein localization (GO:0045176)2.59497470
123positive regulation of steroid metabolic process (GO:0045940)2.58957860
124phospholipid efflux (GO:0033700)2.58865617
125acetyl-CoA metabolic process (GO:0006084)2.56310944
126arginine metabolic process (GO:0006525)2.55370624
127imidazole-containing compound metabolic process (GO:0052803)2.53997816
128nucleobase catabolic process (GO:0046113)2.52661701
129retinal rod cell development (GO:0046548)2.52370881
130organic acid catabolic process (GO:0016054)2.50924125
131carboxylic acid catabolic process (GO:0046395)2.50924125
132drug catabolic process (GO:0042737)2.49711421
133peptidyl-tyrosine autophosphorylation (GO:0038083)2.49126978
134cellular modified amino acid catabolic process (GO:0042219)2.48986046
135very-low-density lipoprotein particle assembly (GO:0034379)2.48983486
136opsonization (GO:0008228)2.47874990
137negative regulation of cytosolic calcium ion concentration (GO:0051481)2.47622563
138monocarboxylic acid catabolic process (GO:0072329)2.45513285
139cytolysis (GO:0019835)2.45135651
140negative regulation of sterol transport (GO:0032372)2.44021205
141negative regulation of cholesterol transport (GO:0032375)2.44021205
142phospholipid homeostasis (GO:0055091)2.43012018
143positive regulation of synapse maturation (GO:0090129)2.41900559
144positive regulation of glycolytic process (GO:0045821)2.40936110
145positive regulation of lipid catabolic process (GO:0050996)2.37849276
146pyrimidine nucleobase catabolic process (GO:0006208)2.37523738

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.27121175
2GBX2_23144817_ChIP-Seq_PC3_Human3.22577695
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.15584089
4* LXR_22158963_ChIP-Seq_LIVER_Mouse2.61258715
5EZH2_22144423_ChIP-Seq_EOC_Human2.56878325
6EGR1_23403033_ChIP-Seq_LIVER_Mouse2.46231104
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.45108663
8PPARA_22158963_ChIP-Seq_LIVER_Mouse2.39347545
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.08653289
10* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.06129542
11* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.01094702
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.98320596
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.88870912
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.87779216
15* EZH2_27294783_Chip-Seq_ESCs_Mouse1.79503938
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.78330310
17* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.78265916
18DROSHA_22980978_ChIP-Seq_HELA_Human1.77960012
19* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.73800388
20* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.72350122
21EED_16625203_ChIP-ChIP_MESCs_Mouse1.68078199
22* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.66745434
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.66620836
24ZFP57_27257070_Chip-Seq_ESCs_Mouse1.65055791
25* EZH2_27304074_Chip-Seq_ESCs_Mouse1.64309100
26PIAS1_25552417_ChIP-Seq_VCAP_Human1.63547473
27* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.63498990
28* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.63498990
29PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.59920223
30* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.59342265
31* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.58019103
32AR_21572438_ChIP-Seq_LNCaP_Human1.57532844
33* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56476247
34REST_21632747_ChIP-Seq_MESCs_Mouse1.54150881
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53909794
36* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.52571267
37SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49311548
38TAF15_26573619_Chip-Seq_HEK293_Human1.47614102
39* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.47387907
40* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.47368149
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.42313616
42* SMAD4_21799915_ChIP-Seq_A2780_Human1.40970636
43CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.37938424
44HTT_18923047_ChIP-ChIP_STHdh_Human1.37551670
45* RNF2_27304074_Chip-Seq_ESCs_Mouse1.35531677
46* HNF4A_19822575_ChIP-Seq_HepG2_Human1.35212383
47POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33396105
48TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33396105
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.32695054
50REST_18959480_ChIP-ChIP_MESCs_Mouse1.30542704
51POU3F2_20337985_ChIP-ChIP_501MEL_Human1.29196855
52SUZ12_27294783_Chip-Seq_NPCs_Mouse1.29184981
53* FOXA2_19822575_ChIP-Seq_HepG2_Human1.28524784
54* P300_19829295_ChIP-Seq_ESCs_Human1.28194624
55ZNF274_21170338_ChIP-Seq_K562_Hela1.27876732
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26945302
57AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.26461292
58IGF1R_20145208_ChIP-Seq_DFB_Human1.26249748
59* TCF4_18268006_ChIP-ChIP_LS174T_Human1.26105035
60STAT3_23295773_ChIP-Seq_U87_Human1.24394437
61* RNF2_27304074_Chip-Seq_NSC_Mouse1.21639374
62RARB_27405468_Chip-Seq_BRAIN_Mouse1.19194092
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18070204
64VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.17413391
65ZNF217_24962896_ChIP-Seq_MCF-7_Human1.17031493
66* NFE2_27457419_Chip-Seq_LIVER_Mouse1.16875424
67* EZH2_27294783_Chip-Seq_NPCs_Mouse1.15775277
68* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14383311
69CDX2_19796622_ChIP-Seq_MESCs_Mouse1.14152206
70CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.14060080
71* SOX2_21211035_ChIP-Seq_LN229_Gbm1.13323203
72ER_23166858_ChIP-Seq_MCF-7_Human1.12540152
73ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.12431562
74TP53_18474530_ChIP-ChIP_U2OS_Human1.12245000
75NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10945787
76* CBX2_27304074_Chip-Seq_ESCs_Mouse1.09794153
77CTNNB1_20460455_ChIP-Seq_HCT116_Human1.09594539
78* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.08680252
79CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.08404640
80TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07254518
81KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07193164
82ARNT_22903824_ChIP-Seq_MCF-7_Human1.06837227
83TCF4_22108803_ChIP-Seq_LS180_Human1.06753927
84PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06242804
85RUNX2_22187159_ChIP-Seq_PCA_Human1.05649145
86TP53_16413492_ChIP-PET_HCT116_Human1.05345924
87EP300_21415370_ChIP-Seq_HL-1_Mouse1.05146914
88* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05064114
89RBPJ_22232070_ChIP-Seq_NCS_Mouse1.04424592
90P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04265511
91TCF4_23295773_ChIP-Seq_U87_Human1.03983517
92* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.03015334
93* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.02837409
94* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02248282
95AHR_22903824_ChIP-Seq_MCF-7_Human1.02016758
96TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00502600
97* AR_25329375_ChIP-Seq_VCAP_Human0.99138501
98* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98124309
99* AR_19668381_ChIP-Seq_PC3_Human0.95902003
100NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.95020271
101NRF2_20460467_ChIP-Seq_MEFs_Mouse0.95020271
102UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94511246
103* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.94304876
104FUS_26573619_Chip-Seq_HEK293_Human0.94215369
105TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.93894845
106SMAD4_21741376_ChIP-Seq_HESCs_Human0.93788092
107BCAT_22108803_ChIP-Seq_LS180_Human0.92621019
108* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92303747
109* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92061539
110ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91822115
111TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91476925
112BMI1_23680149_ChIP-Seq_NPCS_Mouse0.90843484
113VDR_22108803_ChIP-Seq_LS180_Human0.90554523
114ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.90310389
115CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.89207605
116* RING1B_27294783_Chip-Seq_ESCs_Mouse0.88479079
117IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.86826688
118CBP_20019798_ChIP-Seq_JUKART_Human0.86826688
119FLI1_21867929_ChIP-Seq_TH2_Mouse0.86540982
120* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.86144540
121* NANOG_18555785_Chip-Seq_ESCs_Mouse0.85631537

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.08300888
2MP0005360_urolithiasis4.58819174
3MP0005365_abnormal_bile_salt4.25278462
4MP0005085_abnormal_gallbladder_physiolo4.06495425
5MP0008875_abnormal_xenobiotic_pharmacok3.32759485
6MP0005551_abnormal_eye_electrophysiolog2.87587440
7MP0003122_maternal_imprinting2.82766934
8MP0003252_abnormal_bile_duct2.73008320
9MP0003806_abnormal_nucleotide_metabolis2.57031936
10MP0003195_calcinosis2.44146150
11MP0004859_abnormal_synaptic_plasticity2.17100493
12MP0010329_abnormal_lipoprotein_level2.09633418
13MP0002090_abnormal_vision2.03136514
14MP0003329_amyloid_beta_deposits1.94304956
15MP0003880_abnormal_central_pattern1.89004768
16MP0002822_catalepsy1.87360856
17MP0006072_abnormal_retinal_apoptosis1.75910856
18MP0005332_abnormal_amino_acid1.73530974
19MP0002837_dystrophic_cardiac_calcinosis1.72366892
20MP0001666_abnormal_nutrient_absorption1.69905349
21MP0003868_abnormal_feces_composition1.68652211
22MP0002064_seizures1.64621353
23MP0005083_abnormal_biliary_tract1.63875011
24MP0009840_abnormal_foam_cell1.63780260
25MP0005253_abnormal_eye_physiology1.63160252
26MP0003635_abnormal_synaptic_transmissio1.61350950
27MP0003950_abnormal_plasma_membrane1.59324390
28MP0001486_abnormal_startle_reflex1.56241911
29MP0002272_abnormal_nervous_system1.55002805
30MP0003890_abnormal_embryonic-extraembry1.54785869
31MP0004270_analgesia1.54702497
32MP0001984_abnormal_olfaction1.52431680
33* MP0002118_abnormal_lipid_homeostasis1.51109151
34MP0009745_abnormal_behavioral_response1.50123977
35MP0001502_abnormal_circadian_rhythm1.49577037
36MP0003123_paternal_imprinting1.46745855
37MP0000920_abnormal_myelination1.45028985
38MP0009046_muscle_twitch1.44025829
39MP0005645_abnormal_hypothalamus_physiol1.41853731
40MP0002229_neurodegeneration1.37726571
41MP0005379_endocrine/exocrine_gland_phen1.35111196
42MP0004043_abnormal_pH_regulation1.33960884
43MP0004215_abnormal_myocardial_fiber1.33719696
44MP0002063_abnormal_learning/memory/cond1.32942709
45MP0003690_abnormal_glial_cell1.32530546
46MP0003787_abnormal_imprinting1.29333431
47MP0002572_abnormal_emotion/affect_behav1.28488001
48MP0003879_abnormal_hair_cell1.28079492
49MP0003121_genomic_imprinting1.25699790
50MP0000639_abnormal_adrenal_gland1.23478837
51MP0000604_amyloidosis1.23344127
52MP0004885_abnormal_endolymph1.19346245
53MP0004019_abnormal_vitamin_homeostasis1.19074608
54MP0003011_delayed_dark_adaptation1.17590520
55* MP0005195_abnormal_posterior_eye1.16914734
56MP0005646_abnormal_pituitary_gland1.16597432
57MP0001346_abnormal_lacrimal_gland1.15451404
58MP0005423_abnormal_somatic_nervous1.12898600
59MP0005448_abnormal_energy_balance1.11041112
60MP0005670_abnormal_white_adipose1.08477378
61MP0004036_abnormal_muscle_relaxation1.07014346
62MP0006276_abnormal_autonomic_nervous1.05957764
63MP0002067_abnormal_sensory_capabilities1.05691031
64MP0002138_abnormal_hepatobiliary_system1.03401580
65MP0003646_muscle_fatigue1.03262075
66MP0009697_abnormal_copulation1.02719867
67MP0004142_abnormal_muscle_tone1.01401775
68MP0008775_abnormal_heart_ventricle0.98202075
69MP0002909_abnormal_adrenal_gland0.98133261
70MP0005451_abnormal_body_composition0.98014064
71MP0009780_abnormal_chondrocyte_physiolo0.97581505
72MP0005187_abnormal_penis_morphology0.96626373
73MP0000778_abnormal_nervous_system0.96502106
74MP0002638_abnormal_pupillary_reflex0.96230862
75MP0004085_abnormal_heartbeat0.95819162
76MP0005386_behavior/neurological_phenoty0.95770968
77MP0004924_abnormal_behavior0.95770968
78MP0003633_abnormal_nervous_system0.95208709
79MP0003136_yellow_coat_color0.94558367
80* MP0001944_abnormal_pancreas_morphology0.93768379
81MP0003632_abnormal_nervous_system0.93735340
82MP0001485_abnormal_pinna_reflex0.92171169
83MP0003634_abnormal_glial_cell0.91336472
84MP0005584_abnormal_enzyme/coenzyme_acti0.91276054
85MP0005167_abnormal_blood-brain_barrier0.90883736
86MP0002163_abnormal_gland_morphology0.90296528
87* MP0000609_abnormal_liver_physiology0.90223909
88MP0004130_abnormal_muscle_cell0.88728555
89MP0003631_nervous_system_phenotype0.88516215
90MP0002734_abnormal_mechanical_nocicepti0.87699004
91* MP0002882_abnormal_neuron_morphology0.86536104
92MP0003137_abnormal_impulse_conducting0.86180908
93MP0002928_abnormal_bile_duct0.84910508
94MP0001764_abnormal_homeostasis0.84434387
95MP0001661_extended_life_span0.83283286
96MP0002184_abnormal_innervation0.82988668
97MP0002876_abnormal_thyroid_physiology0.82279539
98MP0004084_abnormal_cardiac_muscle0.81985071
99MP0005248_abnormal_Harderian_gland0.81358307
100* MP0002078_abnormal_glucose_homeostasis0.80506898
101* MP0005319_abnormal_enzyme/_coenzyme0.80126702
102* MP0003953_abnormal_hormone_level0.79730685
103MP0002735_abnormal_chemical_nociception0.79698623
104MP0005084_abnormal_gallbladder_morpholo0.78090817
105MP0001756_abnormal_urination0.78072611
106MP0003119_abnormal_digestive_system0.77980635
107MP0002971_abnormal_brown_adipose0.77598133
108MP0000566_synostosis0.77381621
109* MP0002752_abnormal_somatic_nervous0.77295856
110MP0001501_abnormal_sleep_pattern0.77092129
111MP0003283_abnormal_digestive_organ0.75669384
112MP0005535_abnormal_body_temperature0.74585779
113MP0000955_abnormal_spinal_cord0.74305318
114MP0005409_darkened_coat_color0.73715151
115* MP0002066_abnormal_motor_capabilities/c0.73492607
116MP0008569_lethality_at_weaning0.73114468
117MP0004742_abnormal_vestibular_system0.73071225
118MP0002089_abnormal_postnatal_growth/wei0.72538003
119MP0001905_abnormal_dopamine_level0.72116897
120MP0005647_abnormal_sex_gland0.71901017
121MP0005595_abnormal_vascular_smooth0.70603918
122MP0000631_abnormal_neuroendocrine_gland0.70596010
123MP0005391_vision/eye_phenotype0.69747262
124MP0002557_abnormal_social/conspecific_i0.68989889
125MP0004133_heterotaxia0.68953182
126* MP0005220_abnormal_exocrine_pancreas0.68767462
127MP0002234_abnormal_pharynx_morphology0.68219296
128MP0001324_abnormal_eye_pigmentation0.67685735
129MP0005330_cardiomyopathy0.67183262
130MP0000230_abnormal_systemic_arterial0.66620794
131MP0004145_abnormal_muscle_electrophysio0.66317861
132* MP0002069_abnormal_eating/drinking_beha0.66124380
133MP0002127_abnormal_cardiovascular_syste0.65721185
134MP0004185_abnormal_adipocyte_glucose0.64396470

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)5.99800184
2Intrahepatic cholestasis (HP:0001406)5.51262100
3Abnormality of aromatic amino acid family metabolism (HP:0004338)5.44284384
4Deep venous thrombosis (HP:0002625)4.76584755
5Prolonged partial thromboplastin time (HP:0003645)4.33369300
6Glomerulonephritis (HP:0000099)4.04832060
7Central scotoma (HP:0000603)3.94560011
8Hyperlipoproteinemia (HP:0010980)3.94031257
9Abnormality of monocarboxylic acid metabolism (HP:0010996)3.90964614
10Xanthomatosis (HP:0000991)3.90132514
11Ketosis (HP:0001946)3.56062461
12Hypobetalipoproteinemia (HP:0003563)3.52073939
13Hyperventilation (HP:0002883)3.47210602
14Hepatoblastoma (HP:0002884)3.40223913
15Complement deficiency (HP:0004431)3.35881500
16Abnormality of macular pigmentation (HP:0008002)3.34519958
17Epidermoid cyst (HP:0200040)3.24529330
18Hypoglycemic coma (HP:0001325)3.24331299
19Ketoacidosis (HP:0001993)3.22709634
20Conjugated hyperbilirubinemia (HP:0002908)3.19311242
21Systemic lupus erythematosus (HP:0002725)3.04885402
22Decreased central vision (HP:0007663)3.01067939
23Hypoglycemic seizures (HP:0002173)3.00343548
24Potter facies (HP:0002009)2.99594633
25Facial shape deformation (HP:0011334)2.99594633
26Hyperinsulinemic hypoglycemia (HP:0000825)2.97694367
27Vascular calcification (HP:0004934)2.92856007
28Arthropathy (HP:0003040)2.87549691
29Hyperammonemia (HP:0001987)2.83921993
30Progressive cerebellar ataxia (HP:0002073)2.82267878
31Abnormality of methionine metabolism (HP:0010901)2.82067951
32Fat malabsorption (HP:0002630)2.77062653
33Hypolipoproteinemia (HP:0010981)2.76086357
34Cholecystitis (HP:0001082)2.75080388
35Abnormal gallbladder physiology (HP:0012438)2.75080388
36Joint hemorrhage (HP:0005261)2.73561158
37Abnormality of sulfur amino acid metabolism (HP:0004339)2.68895972
38Hyperglycinemia (HP:0002154)2.67137380
39Abnormality of the common coagulation pathway (HP:0010990)2.66248805
40Hypoalphalipoproteinemia (HP:0003233)2.64489629
41Epileptic encephalopathy (HP:0200134)2.64472920
42Abnormality of aspartate family amino acid metabolism (HP:0010899)2.63438620
43Severe visual impairment (HP:0001141)2.62936212
44Neurofibrillary tangles (HP:0002185)2.62038353
45Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.60908706
46Degeneration of the lateral corticospinal tracts (HP:0002314)2.60908706
47Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.60256833
48Osteomalacia (HP:0002749)2.56142146
49Abnormality of glycine metabolism (HP:0010895)2.55554711
50Abnormality of serine family amino acid metabolism (HP:0010894)2.55554711
51Abnormality of the corticospinal tract (HP:0002492)2.49284936
52Abnormal pancreas size (HP:0012094)2.45529250
53Nephritis (HP:0000123)2.42629239
54Mitral stenosis (HP:0001718)2.40951607
55Cardiovascular calcification (HP:0011915)2.40105607
56Scotoma (HP:0000575)2.39809102
57Spontaneous abortion (HP:0005268)2.38138358
58Pancreatic islet-cell hyperplasia (HP:0004510)2.33358810
59Hypercholesterolemia (HP:0003124)2.32195707
60Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.30469928
61Acanthocytosis (HP:0001927)2.29860124
62Skin nodule (HP:0200036)2.26407429
63Focal motor seizures (HP:0011153)2.22201186
64Abnormality of glutamine family amino acid metabolism (HP:0010902)2.21789058
65Abnormal gallbladder morphology (HP:0012437)2.20704845
66EEG with generalized epileptiform discharges (HP:0011198)2.19081057
67Hyperglycinuria (HP:0003108)2.17748951
68Hypothermia (HP:0002045)2.16922895
69Myokymia (HP:0002411)2.16548411
70Epileptiform EEG discharges (HP:0011182)2.15544595
71Generalized aminoaciduria (HP:0002909)2.15039166
72Scanning speech (HP:0002168)2.14468538
73Spastic gait (HP:0002064)2.13930202
74Symptomatic seizures (HP:0011145)2.13132391
75Abnormality of the intrinsic pathway (HP:0010989)2.10293546
76Drooling (HP:0002307)2.10122164
77Excessive salivation (HP:0003781)2.10122164
78Metabolic acidosis (HP:0001942)2.07442155
79Hypochromic microcytic anemia (HP:0004840)2.07328120
80Abnormality of fatty-acid metabolism (HP:0004359)2.05984713
81Syncope (HP:0001279)2.04763316
82Enlarged kidneys (HP:0000105)2.04118931
83Abnormality of urine glucose concentration (HP:0011016)2.03825172
84Glycosuria (HP:0003076)2.03825172
85Proximal tubulopathy (HP:0000114)2.03507934
86Rickets (HP:0002748)2.03402258
87Abnormality of the lower motor neuron (HP:0002366)2.02028636
88Abnormality of complement system (HP:0005339)1.99539943
89Hyperbilirubinemia (HP:0002904)1.99260158
90Absence seizures (HP:0002121)1.97941613
91Hyperglycemia (HP:0003074)1.97502481
92Cholelithiasis (HP:0001081)1.97379937
93Cerebral inclusion bodies (HP:0100314)1.97324087
94Thickened helices (HP:0000391)1.96907645
95Steatorrhea (HP:0002570)1.95163381
96Fair hair (HP:0002286)1.95041269
97Hypophosphatemic rickets (HP:0004912)1.94507961
98Dialeptic seizures (HP:0011146)1.94505316
99Abnormality of vitamin metabolism (HP:0100508)1.94392333
100Hypsarrhythmia (HP:0002521)1.92636875
101Bifid scrotum (HP:0000048)1.92170710
102Abolished electroretinogram (ERG) (HP:0000550)1.92023500
103Prolonged QT interval (HP:0001657)1.91879685
104Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.91237818
105Nuclear cataract (HP:0100018)1.90951304
106Abnormality of the pancreatic islet cells (HP:0006476)1.90880941
107Abnormality of endocrine pancreas physiology (HP:0012093)1.90880941
108Menorrhagia (HP:0000132)1.90002355
109Insidious onset (HP:0003587)1.88405274
110Termporal pattern (HP:0011008)1.88405274
111Gout (HP:0001997)1.87546692
112Hyperphosphaturia (HP:0003109)1.87387310
113Blue irides (HP:0000635)1.84987858
114Abnormality of serum amino acid levels (HP:0003112)1.84602488
115Late onset (HP:0003584)1.84549546
116Genetic anticipation (HP:0003743)1.84512693
117Intestinal atresia (HP:0011100)1.83736964
118Abnormality of the nasal septum (HP:0000419)1.83168766
119Zonular cataract (HP:0010920)1.82947542
120Agitation (HP:0000713)1.81446389
121Severe Myopia (HP:0011003)1.80317945
122Chorioretinal atrophy (HP:0000533)1.79324144
123Submucous cleft hard palate (HP:0000176)1.78547065
124Abnormal rod and cone electroretinograms (HP:0008323)1.78431091
125Cerebral edema (HP:0002181)1.78152500
126Cone-rod dystrophy (HP:0000548)1.76955777
127Febrile seizures (HP:0002373)1.76556737
128Pheochromocytoma (HP:0002666)1.76514296
129Exercise-induced myalgia (HP:0003738)1.76044875
130Recurrent gram-negative bacterial infections (HP:0005420)1.75765300
131Abnormality of the gallbladder (HP:0005264)1.74214365
132Neonatal hypoglycemia (HP:0001998)1.74184222
133Chronic hepatic failure (HP:0100626)1.73987921
134Dysmetria (HP:0001310)1.73023179
135Morphological abnormality of the pyramidal tract (HP:0002062)1.72635415
136Hemiparesis (HP:0001269)1.72302775
137Delayed CNS myelination (HP:0002188)1.71569517
138Status epilepticus (HP:0002133)1.69615632
139Diastasis recti (HP:0001540)1.68097080
140Congenital malformation of the right heart (HP:0011723)1.66744082
141Double outlet right ventricle (HP:0001719)1.66744082
142Gingival bleeding (HP:0000225)1.63776793
143Abnormal biliary tract physiology (HP:0012439)1.63416298
144Bile duct proliferation (HP:0001408)1.63416298
145Abnormal urine phosphate concentration (HP:0012599)1.62278685
146Alacrima (HP:0000522)1.61444610
147Abnormal urine output (HP:0012590)1.59600877
148Hepatocellular carcinoma (HP:0001402)1.59530639
149Gaze-evoked nystagmus (HP:0000640)1.55406127
150Hemorrhage of the eye (HP:0011885)1.55041673
151Papillary thyroid carcinoma (HP:0002895)1.54321969
152Vaginal fistula (HP:0004320)1.53429467
153Neoplasm of the liver (HP:0002896)1.52860772
154Anosmia (HP:0000458)1.52356432
155Abnormality of purine metabolism (HP:0004352)1.50948779
156Abnormality of nucleobase metabolism (HP:0010932)1.50917405
157Abnormality of pyrimidine metabolism (HP:0004353)1.50848953
158Abnormality of the vitreous humor (HP:0004327)1.50187905
159Retinal atrophy (HP:0001105)1.49032171

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.11022566
2INSRR4.07694134
3NTRK32.64773177
4STK392.38140902
5FGFR32.28194631
6EPHA42.26147411
7PRPF4B2.25894249
8MAPK152.18718078
9BCKDK2.15579310
10SIK22.09379139
11WNK32.05687507
12PKN12.03153365
13ERBB41.89271328
14PIK3CA1.87045026
15BMPR1B1.82981291
16TNIK1.72974373
17SGK2231.72886790
18SGK4941.72886790
19CASK1.70297155
20STK38L1.63176893
21OXSR11.59892533
22PBK1.58490896
23PAK31.56983489
24FGFR21.52580163
25MARK11.52296522
26PAK61.50859127
27MAP3K131.50829115
28CAMK2D1.48962868
29BCR1.46034497
30MAP3K41.44985656
31EPHB11.44071277
32WNK41.42119628
33SIK11.32135946
34MAP2K41.31124724
35PINK11.30748911
36CAMK2B1.30424262
37PHKG21.29274202
38PHKG11.29274202
39CAMK1G1.21827943
40MAP3K71.21349823
41NTRK21.20212672
42TAOK31.18204134
43UHMK11.16219389
44CAMK2A1.15733551
45WNK11.08812340
46FER1.07043425
47KSR21.04270843
48MUSK1.03026515
49EPHA31.00240336
50CAMK2G0.99459104
51OBSCN0.97573007
52STK240.97562935
53SGK20.96834190
54MAP2K70.95218634
55DAPK20.93737975
56CAMKK20.93573240
57FGFR40.93073112
58CSNK1A1L0.92609482
59FGFR10.92105451
60ICK0.90190402
61ACVR1B0.88270258
62PRKCE0.85986543
63MAP3K90.85432340
64MAP3K20.83313480
65CDC42BPA0.82458519
66CDK50.81991172
67PNCK0.81774650
68DYRK1B0.81516600
69MARK20.81284668
70CSNK1G20.80227830
71PRKCG0.79607536
72STK30.79558910
73CDK30.78621381
74TYRO30.77212522
75CSNK1G30.77207802
76PRKCZ0.76603803
77STK110.76547460
78MET0.76356746
79FES0.75843443
80SGK30.75744334
81PRKCH0.75652675
82NEK90.75613424
83PRKAA10.74880627
84AKT30.74795935
85DYRK1A0.74619812
86GRK10.74295844
87NLK0.74184060
88PRKG10.73326000
89ARAF0.73303538
90CAMK1D0.72623863
91DYRK20.72252749
92CSNK1G10.71595734
93CAMK10.71492597
94MAPK70.71104543
95NEK60.71010346
96PIK3CG0.70908545
97MAP4K20.70506203
98ERBB20.67140529
99RET0.66949582
100STK380.66881836
101PTK2B0.66796266
102PRKAA20.66727738
103NTRK10.65670076
104IRAK20.65402347
105PRKD10.63437604
106SGK10.62887127
107PRKACB0.62767913
108CSNK1D0.62748022
109MKNK20.62401616
110CAMKK10.60817542
111LATS10.60678839
112MAPK110.60346155
113PDK10.59816130
114CSNK1E0.59281570
115MINK10.58412502
116KSR10.57475214
117PKN20.57132471
118RPS6KA30.55778104
119ADRBK20.55012404
120CAMK40.54840366
121MAPK130.54732521
122BRSK20.54690904
123PRKACG0.54626537
124BRD40.53838252
125ROCK20.53376303
126MAP3K10.53177744
127HIPK20.52509138
128PRKACA0.52269632
129RIPK10.50600443
130DMPK0.43743065
131ROCK10.42047210

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.52282417
2Nitrogen metabolism_Homo sapiens_hsa009103.30414410
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.88602151
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.67993031
5Arginine biosynthesis_Homo sapiens_hsa002202.60517674
6Butanoate metabolism_Homo sapiens_hsa006502.39620993
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.10262199
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.09416511
9Tryptophan metabolism_Homo sapiens_hsa003802.08367740
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.06472018
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.02929782
12Complement and coagulation cascades_Homo sapiens_hsa046101.94249646
13Fatty acid elongation_Homo sapiens_hsa000621.92618016
14Fatty acid degradation_Homo sapiens_hsa000711.91973552
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.80017349
16Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.75798319
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.70012876
18Propanoate metabolism_Homo sapiens_hsa006401.69835552
19Histidine metabolism_Homo sapiens_hsa003401.66933765
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.62930690
21GABAergic synapse_Homo sapiens_hsa047271.62488210
22Fatty acid metabolism_Homo sapiens_hsa012121.61791804
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.61403487
24Peroxisome_Homo sapiens_hsa041461.60575407
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.47911066
26Bile secretion_Homo sapiens_hsa049761.36983521
27PPAR signaling pathway_Homo sapiens_hsa033201.36200329
28Steroid biosynthesis_Homo sapiens_hsa001001.36109324
29Nicotine addiction_Homo sapiens_hsa050331.36052949
30beta-Alanine metabolism_Homo sapiens_hsa004101.32177133
31Sulfur metabolism_Homo sapiens_hsa009201.31475759
32Retinol metabolism_Homo sapiens_hsa008301.24964257
33Chemical carcinogenesis_Homo sapiens_hsa052041.20213985
34ABC transporters_Homo sapiens_hsa020101.18780123
35Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.16025251
36Phenylalanine metabolism_Homo sapiens_hsa003601.13689719
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.13590550
38Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.10504601
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.09998911
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.09610521
41Tyrosine metabolism_Homo sapiens_hsa003501.07765197
42Pyruvate metabolism_Homo sapiens_hsa006201.04034880
43Insulin secretion_Homo sapiens_hsa049111.04029121
44Circadian entrainment_Homo sapiens_hsa047131.02985617
45Morphine addiction_Homo sapiens_hsa050321.02690510
46Pentose and glucuronate interconversions_Homo sapiens_hsa000401.00160441
47Fatty acid biosynthesis_Homo sapiens_hsa000610.95901460
48Fat digestion and absorption_Homo sapiens_hsa049750.92465970
49Biosynthesis of amino acids_Homo sapiens_hsa012300.91817856
50Arginine and proline metabolism_Homo sapiens_hsa003300.91715524
51Glutamatergic synapse_Homo sapiens_hsa047240.90507030
52Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.89945433
53Carbon metabolism_Homo sapiens_hsa012000.84807524
54Lysine degradation_Homo sapiens_hsa003100.82955257
55Staphylococcus aureus infection_Homo sapiens_hsa051500.82057785
56Starch and sucrose metabolism_Homo sapiens_hsa005000.81820882
57Synaptic vesicle cycle_Homo sapiens_hsa047210.81353923
58Drug metabolism - other enzymes_Homo sapiens_hsa009830.79058581
59Caffeine metabolism_Homo sapiens_hsa002320.78157624
60Phototransduction_Homo sapiens_hsa047440.78066473
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.77673898
62Selenocompound metabolism_Homo sapiens_hsa004500.72192339
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.69711405
64Vitamin digestion and absorption_Homo sapiens_hsa049770.69218469
65Vitamin B6 metabolism_Homo sapiens_hsa007500.67794334
66Glycerolipid metabolism_Homo sapiens_hsa005610.65228439
67Serotonergic synapse_Homo sapiens_hsa047260.63103755
68Prion diseases_Homo sapiens_hsa050200.60072780
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59440874
70Glucagon signaling pathway_Homo sapiens_hsa049220.58885755
71Circadian rhythm_Homo sapiens_hsa047100.58821119
72Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.57508865
73Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.56911761
74Olfactory transduction_Homo sapiens_hsa047400.56566191
75Type II diabetes mellitus_Homo sapiens_hsa049300.56154301
76Taste transduction_Homo sapiens_hsa047420.56125855
77Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.55447485
78Aldosterone synthesis and secretion_Homo sapiens_hsa049250.53833213
79alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51873543
80Linoleic acid metabolism_Homo sapiens_hsa005910.51626969
81Renin secretion_Homo sapiens_hsa049240.51325087
82Folate biosynthesis_Homo sapiens_hsa007900.51276456
83Cholinergic synapse_Homo sapiens_hsa047250.49705717
84Amphetamine addiction_Homo sapiens_hsa050310.49176202
85Thyroid hormone synthesis_Homo sapiens_hsa049180.49167049
86Cardiac muscle contraction_Homo sapiens_hsa042600.48822452
87Dopaminergic synapse_Homo sapiens_hsa047280.46956647
88Ovarian steroidogenesis_Homo sapiens_hsa049130.46917643
89Cocaine addiction_Homo sapiens_hsa050300.46887484
90Arachidonic acid metabolism_Homo sapiens_hsa005900.46180808
91Salivary secretion_Homo sapiens_hsa049700.45641909
92Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43806295
93Insulin resistance_Homo sapiens_hsa049310.41288993
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40617292
95Dilated cardiomyopathy_Homo sapiens_hsa054140.40066718
96Ether lipid metabolism_Homo sapiens_hsa005650.39712407
97Long-term depression_Homo sapiens_hsa047300.38268710
98Axon guidance_Homo sapiens_hsa043600.37240340
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.37137076
100Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.36446495
101Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.35253419
102Metabolic pathways_Homo sapiens_hsa011000.33862903
103Cyanoamino acid metabolism_Homo sapiens_hsa004600.33354570
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.33181480
105cAMP signaling pathway_Homo sapiens_hsa040240.32610127
106Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.32132804
107Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.31933678
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30243767
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.29024124
110AMPK signaling pathway_Homo sapiens_hsa041520.26690885
111Mineral absorption_Homo sapiens_hsa049780.22889516
112Renin-angiotensin system_Homo sapiens_hsa046140.20883778
113Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.19357936

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