PROZ

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a liver vitamin K-dependent glycoprotein that is synthesized in the liver and secreted into the plasma. The encoded protein plays a role in regulating blood coagulation by complexing with protein Z-dependent protease inhibitor to directly inhibit activated factor X at the phospholipid surface. Deficiencies in this protein are associated with an increased risk of ischemic arterial diseases and fetal loss. Mutations in this gene are the cause of protein Z deficiency. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.55309125
2L-phenylalanine catabolic process (GO:0006559)7.55309125
3epoxygenase P450 pathway (GO:0019373)7.38782660
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.21487088
5L-phenylalanine metabolic process (GO:0006558)7.21487088
6exogenous drug catabolic process (GO:0042738)7.19065792
7omega-hydroxylase P450 pathway (GO:0097267)6.93098928
8aromatic amino acid family catabolic process (GO:0009074)6.82713136
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.40359560
10indole-containing compound catabolic process (GO:0042436)6.20137871
11indolalkylamine catabolic process (GO:0046218)6.20137871
12tryptophan catabolic process (GO:0006569)6.20137871
13kynurenine metabolic process (GO:0070189)6.09091754
14bile acid biosynthetic process (GO:0006699)5.97482565
15tryptophan metabolic process (GO:0006568)5.83168658
16glyoxylate metabolic process (GO:0046487)5.77367850
17negative regulation of fibrinolysis (GO:0051918)5.69491318
18urea metabolic process (GO:0019627)5.68850734
19urea cycle (GO:0000050)5.68850734
20high-density lipoprotein particle remodeling (GO:0034375)5.62889040
21alpha-linolenic acid metabolic process (GO:0036109)5.62831835
22regulation of fibrinolysis (GO:0051917)5.49936615
23complement activation, alternative pathway (GO:0006957)5.43231399
24regulation of protein activation cascade (GO:2000257)5.41968491
25regulation of plasminogen activation (GO:0010755)5.33709842
26drug metabolic process (GO:0017144)5.33164528
27cysteine metabolic process (GO:0006534)5.31230166
28oxidative demethylation (GO:0070989)5.30833459
29sulfur amino acid catabolic process (GO:0000098)5.29245644
30nitrogen cycle metabolic process (GO:0071941)5.22438657
31bile acid metabolic process (GO:0008206)5.11004757
32serine family amino acid catabolic process (GO:0009071)5.10494911
33phenylpropanoid metabolic process (GO:0009698)5.09321469
34regulation of complement activation (GO:0030449)5.05366435
35* protein carboxylation (GO:0018214)5.01420697
36* peptidyl-glutamic acid carboxylation (GO:0017187)5.01420697
37aromatic amino acid family metabolic process (GO:0009072)4.95363565
38ethanol metabolic process (GO:0006067)4.94817464
39regulation of cholesterol esterification (GO:0010872)4.93127598
40reverse cholesterol transport (GO:0043691)4.92564067
41fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.90976307
42regulation of triglyceride catabolic process (GO:0010896)4.83352969
43protein-lipid complex remodeling (GO:0034368)4.83352470
44macromolecular complex remodeling (GO:0034367)4.83352470
45plasma lipoprotein particle remodeling (GO:0034369)4.83352470
46tyrosine metabolic process (GO:0006570)4.78376771
47negative regulation of hemostasis (GO:1900047)4.78124741
48negative regulation of blood coagulation (GO:0030195)4.78124741
49homocysteine metabolic process (GO:0050667)4.74140727
50acylglycerol homeostasis (GO:0055090)4.64937567
51triglyceride homeostasis (GO:0070328)4.64937567
52phospholipid efflux (GO:0033700)4.64748325
53alpha-amino acid catabolic process (GO:1901606)4.63932090
54negative regulation of cholesterol transport (GO:0032375)4.62593791
55negative regulation of sterol transport (GO:0032372)4.62593791
56amino-acid betaine metabolic process (GO:0006577)4.59905147
57lysine catabolic process (GO:0006554)4.55987692
58lysine metabolic process (GO:0006553)4.55987692
59negative regulation of protein activation cascade (GO:2000258)4.55720709
60intestinal cholesterol absorption (GO:0030299)4.53165666
61cellular ketone body metabolic process (GO:0046950)4.46386676
62acute-phase response (GO:0006953)4.45100749
63plasma lipoprotein particle clearance (GO:0034381)4.43937800
64regulation of humoral immune response (GO:0002920)4.43212917
65bile acid and bile salt transport (GO:0015721)4.42797809
66negative regulation of wound healing (GO:0061045)4.42577604
67glycine metabolic process (GO:0006544)4.40960386
68indolalkylamine metabolic process (GO:0006586)4.38795643
69imidazole-containing compound metabolic process (GO:0052803)4.38761197
70coenzyme catabolic process (GO:0009109)4.38227899
71negative regulation of coagulation (GO:0050819)4.34850826
72cholesterol efflux (GO:0033344)4.30490210
73cellular biogenic amine catabolic process (GO:0042402)4.30241748
74amine catabolic process (GO:0009310)4.30241748
75glutamate metabolic process (GO:0006536)4.28007897
76cellular amino acid catabolic process (GO:0009063)4.26232483
77cellular glucuronidation (GO:0052695)4.25715737
78alkaloid metabolic process (GO:0009820)4.22361953
79serine family amino acid metabolic process (GO:0009069)4.15833043
80benzene-containing compound metabolic process (GO:0042537)4.14536792
81dicarboxylic acid biosynthetic process (GO:0043650)4.11193076
82ethanol oxidation (GO:0006069)4.08386613
83plasma lipoprotein particle assembly (GO:0034377)4.08314449
84fibrinolysis (GO:0042730)4.06092391
85cellular modified amino acid catabolic process (GO:0042219)4.05408231
86low-density lipoprotein particle remodeling (GO:0034374)4.05097230
87positive regulation of blood coagulation (GO:0030194)4.01830439
88positive regulation of hemostasis (GO:1900048)4.01830439
89serine family amino acid biosynthetic process (GO:0009070)4.00199532
90arginine metabolic process (GO:0006525)3.99805326
91aldehyde catabolic process (GO:0046185)3.95103586
92drug catabolic process (GO:0042737)3.94934375
93S-adenosylmethionine metabolic process (GO:0046500)3.92482442
94fat-soluble vitamin biosynthetic process (GO:0042362)3.92116530
95blood coagulation, intrinsic pathway (GO:0007597)3.90446463
96ketone body metabolic process (GO:1902224)3.86262543
97negative regulation of complement activation (GO:0045916)3.84967223
98protein-lipid complex subunit organization (GO:0071825)3.84395372
99complement activation, classical pathway (GO:0006958)3.82334463
100positive regulation of triglyceride lipase activity (GO:0061365)3.82076739
101positive regulation of lipoprotein lipase activity (GO:0051006)3.82076739
102very-low-density lipoprotein particle assembly (GO:0034379)3.81171959
103phospholipid homeostasis (GO:0055091)3.79812248
104cofactor catabolic process (GO:0051187)3.79426628
105complement activation (GO:0006956)3.78414461
106positive regulation of lipid catabolic process (GO:0050996)3.78130594
107protein activation cascade (GO:0072376)3.77452835
108uronic acid metabolic process (GO:0006063)3.77439201
109glucuronate metabolic process (GO:0019585)3.77439201
110cholesterol homeostasis (GO:0042632)3.77123328
111regulation of bile acid biosynthetic process (GO:0070857)3.75865592
112negative regulation of lipase activity (GO:0060192)3.74601976
113organic acid catabolic process (GO:0016054)3.72070299
114carboxylic acid catabolic process (GO:0046395)3.72070299
115sterol homeostasis (GO:0055092)3.70877578
116cytolysis (GO:0019835)3.69881475
117positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.69307716
118plasma lipoprotein particle organization (GO:0071827)3.68516912
119proline metabolic process (GO:0006560)3.68198209
120regulation of cholesterol homeostasis (GO:2000188)3.67388556
121regulation of lipoprotein particle clearance (GO:0010984)3.65914221
122positive regulation of coagulation (GO:0050820)3.65878547
123protein-lipid complex assembly (GO:0065005)3.65823462
124acetyl-CoA metabolic process (GO:0006084)3.64570904
125short-chain fatty acid metabolic process (GO:0046459)3.63887124
126positive regulation of fatty acid biosynthetic process (GO:0045723)3.57344263
127NAD biosynthetic process (GO:0009435)3.56432692
128opsonization (GO:0008228)3.55723016
129steroid catabolic process (GO:0006706)3.54770717
130killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.48761461
131disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.48761461

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.41354632
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.19368278
3EGR1_23403033_ChIP-Seq_LIVER_Mouse7.03407579
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.51414686
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.32029990
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.10107021
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.77093628
8* NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.03973115
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.99622710
10TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.08392710
11* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.9107856
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.95460544
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91571905
14FOXA2_19822575_ChIP-Seq_HepG2_Human1.63375729
15HTT_18923047_ChIP-ChIP_STHdh_Human1.56476703
16CLOCK_20551151_ChIP-Seq_293T_Human1.50769139
17GATA1_22025678_ChIP-Seq_K562_Human1.46646035
18* HNF4A_19822575_ChIP-Seq_HepG2_Human1.40772180
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.33055891
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.22676548
21RXRA_24833708_ChIP-Seq_LIVER_Mouse1.19304847
22STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.17356246
23RAC3_21632823_ChIP-Seq_H3396_Human1.08413854
24ESR1_15608294_ChIP-ChIP_MCF-7_Human1.07813750
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.06404668
26E2F1_20622854_ChIP-Seq_HELA_Human1.00537524
27CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00319624
28PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00231034
29ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00120892
30MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.98424569
31ELF1_20517297_ChIP-Seq_JURKAT_Human0.96218940
32TP63_17297297_ChIP-ChIP_HaCaT_Human0.93044141
33EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.92952210
34IRF8_22096565_ChIP-ChIP_GC-B_Human0.92187782
35SOX2_27498859_Chip-Seq_STOMACH_Mouse0.91873440
36TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.86560116
37SA1_27219007_Chip-Seq_Bcells_Human0.86047446
38SMC4_20622854_ChIP-Seq_HELA_Human0.84696295
39P68_20966046_ChIP-Seq_HELA_Human0.83608554
40P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.83399973
41* SOX2_21211035_ChIP-Seq_LN229_Human0.82844401
42AUTS2_25519132_ChIP-Seq_293T-REX_Human0.82489231
43ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.82060743
44* BCOR_27268052_Chip-Seq_Bcells_Human0.81928191
45PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.81741119
46SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.80405380
47PHF8_20622854_ChIP-Seq_HELA_Human0.79602594
48RARG_19884340_ChIP-ChIP_MEFs_Mouse0.79347297
49GATA4_25053715_ChIP-Seq_YYC3_Human0.79206592
50ERA_21632823_ChIP-Seq_H3396_Human0.78768101
51BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.78325967
52ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.77919667
53CTCF_20526341_ChIP-Seq_ESCs_Human0.77004215
54Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.75204996
55SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.75022338
56SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.74859292
57KAP1_22055183_ChIP-Seq_ESCs_Mouse0.74579345
58RARA_24833708_ChIP-Seq_LIVER_Mouse0.73325770
59GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.73103800
60CTCF_27219007_Chip-Seq_Bcells_Human0.72806105
61CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.71737417
62OCT4_20526341_ChIP-Seq_ESCs_Human0.71612260
63* BCL6_27268052_Chip-Seq_Bcells_Human0.71556917
64SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.71456496
65CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.70387824
66ZNF263_19887448_ChIP-Seq_K562_Human0.68466129
67MYC_19829295_ChIP-Seq_ESCs_Human0.68403017
68AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.67991189
69* P300_27268052_Chip-Seq_Bcells_Human0.67832204
70DNAJC2_21179169_ChIP-ChIP_NT2_Human0.67260368
71SALL4_18804426_ChIP-ChIP_XEN_Mouse0.66586256
72FOXA1_25329375_ChIP-Seq_VCAP_Human0.66331166
73FOXA1_27270436_Chip-Seq_PROSTATE_Human0.66331166
74CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.66199417
75ESR2_21235772_ChIP-Seq_MCF-7_Human0.65924840
76CSB_26484114_Chip-Seq_FIBROBLAST_Human0.65768633
77NRF2_20460467_ChIP-Seq_MEFs_Mouse0.65113929
78NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.65113929
79JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.64680660
80RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.64669810
81TRIM28_21343339_ChIP-Seq_HEK293_Human0.63648972
82NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.62507206
83PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.62426967
84NANOG_20526341_ChIP-Seq_ESCs_Human0.61876878
85YY1_22570637_ChIP-Seq_MALME-3M_Human0.61301446
86RAD21_21589869_ChIP-Seq_MESCs_Mouse0.60798883
87* GATA3_21867929_ChIP-Seq_CD8_Mouse0.60788162
88* RARB_24833708_ChIP-Seq_LIVER_Mouse0.60781283
89NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.59818106
90BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.59733835
91* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.59013331
92NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.57987180
93CEBPB_22108803_ChIP-Seq_LS180_Human0.57458702
94FOXH1_21741376_ChIP-Seq_ESCs_Human0.56675284
95SOX2_22085726_ChIP-Seq_NPCs_Mouse0.56517215
96SRY_22984422_ChIP-ChIP_TESTIS_Rat0.56515105
97TET1_21451524_ChIP-Seq_MESCs_Mouse0.55741715
98EGR1_19032775_ChIP-ChIP_M12_Human0.55670742
99LXR_22292898_ChIP-Seq_THP-1_Human0.55247156
100TP53_16413492_ChIP-PET_HCT116_Human0.54964623
101CTCF_21964334_ChIP-Seq_BJAB-B_Human0.54408447
102FOXA1_25552417_ChIP-Seq_VCAP_Human0.53677796
103MYC_19915707_ChIP-ChIP_AK7_Human0.51786112
104TAF15_26573619_Chip-Seq_HEK293_Human0.51166303
105AR_20517297_ChIP-Seq_VCAP_Human0.50687013
106FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.50456184
107FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.50298643
108* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.49786506
109CBP_21632823_ChIP-Seq_H3396_Human0.48391877
110STAT3_1855785_ChIP-Seq_MESCs_Mouse0.47725228
111ESET_19884257_ChIP-Seq_ESCs_Mouse0.47671282
112STAT1_17558387_ChIP-Seq_HELA_Human0.47322804
113CDX2_20551321_ChIP-Seq_CACO-2_Human0.46603113
114GATA1_19941827_ChIP-Seq_MEL_Mouse0.46194981
115GATA1_19941826_ChIP-Seq_K562_Human0.44849677
116PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.44622850
117* P53_21459846_ChIP-Seq_SAOS-2_Human0.43556005
118PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.43459442
119ESR1_21235772_ChIP-Seq_MCF-7_Human0.42531768
120PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.42465570
121GATA2_19941826_ChIP-Seq_K562_Human0.42206983
122FOXO3_23340844_ChIP-Seq_DLD1_Human0.41523014
123ERG_21242973_ChIP-ChIP_JURKAT_Human0.41487384
124CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.41299828
125ESR1_20079471_ChIP-ChIP_T-47D_Human0.41122260
126SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.40868486
127FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.40509598
128FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.40261639
129BCAT_22108803_ChIP-Seq_LS180_Human0.40142903
130PPAR_26484153_Chip-Seq_NCI-H1993_Human0.39852735
131E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.39375259
132* TAF2_19829295_ChIP-Seq_ESCs_Human0.38884234
133GATA6_25053715_ChIP-Seq_YYC3_Human0.38878492
134GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.38640906
135MYC_27129775_Chip-Seq_CORNEA_Mouse0.38394229
136STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.37398912
137SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.36370486
138LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.35888227
139SPI1_26923725_Chip-Seq_HPCs_Mouse0.34821133
140FOXH1_21741376_ChIP-Seq_EPCs_Human0.34008085
141BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.33348994
142NCOR_22424771_ChIP-Seq_293T_Human0.33268233
143CDX2_22108803_ChIP-Seq_LS180_Human0.32747356

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.34266578
2MP0005360_urolithiasis7.57996900
3MP0005085_abnormal_gallbladder_physiolo6.46467215
4MP0005365_abnormal_bile_salt6.17140184
5MP0008875_abnormal_xenobiotic_pharmacok5.12102755
6MP0003806_abnormal_nucleotide_metabolis4.22015881
7MP0003252_abnormal_bile_duct3.94622215
8MP0010329_abnormal_lipoprotein_level3.61753320
9MP0009840_abnormal_foam_cell3.29062113
10MP0005083_abnormal_biliary_tract3.13020571
11MP0003195_calcinosis2.81515254
12MP0005332_abnormal_amino_acid2.73225484
13MP0001666_abnormal_nutrient_absorption2.61295472
14MP0003191_abnormal_cellular_cholesterol2.34077666
15MP0000609_abnormal_liver_physiology2.17613778
16MP0004019_abnormal_vitamin_homeostasis2.11758351
17MP0002118_abnormal_lipid_homeostasis2.10898372
18MP0002138_abnormal_hepatobiliary_system1.94695801
19MP0003868_abnormal_feces_composition1.91016785
20MP0005319_abnormal_enzyme/_coenzyme1.82568435
21MP0001764_abnormal_homeostasis1.66001581
22MP0009697_abnormal_copulation1.60811346
23MP0005584_abnormal_enzyme/coenzyme_acti1.56901452
24MP0005451_abnormal_body_composition1.41741919
25MP0003011_delayed_dark_adaptation1.37126526
26MP0003656_abnormal_erythrocyte_physiolo1.28544742
27MP0003186_abnormal_redox_activity1.21998192
28MP0009643_abnormal_urine_homeostasis1.21130014
29MP0000566_synostosis1.18610082
30MP0000598_abnormal_liver_morphology1.17925292
31MP0003705_abnormal_hypodermis_morpholog1.13999828
32MP0005647_abnormal_sex_gland1.13721160
33MP0000604_amyloidosis1.11591708
34MP0009764_decreased_sensitivity_to1.07061234
35MP0002254_reproductive_system_inflammat1.06657790
36MP0010368_abnormal_lymphatic_system0.99550708
37* MP0009763_increased_sensitivity_to0.98196313
38MP0003172_abnormal_lysosome_physiology0.98138925
39MP0001915_intracranial_hemorrhage0.94589552
40MP0005636_abnormal_mineral_homeostasis0.91989033
41MP0008469_abnormal_protein_level0.90267611
42* MP0009642_abnormal_blood_homeostasis0.86504933
43MP0000371_diluted_coat_color0.85233434
44MP0005408_hypopigmentation0.81554421
45MP0005084_abnormal_gallbladder_morpholo0.80504882
46MP0009765_abnormal_xenobiotic_induced0.79822411
47MP0006036_abnormal_mitochondrial_physio0.79612846
48MP0005376_homeostasis/metabolism_phenot0.79011750
49MP0002876_abnormal_thyroid_physiology0.78265723
50MP0002078_abnormal_glucose_homeostasis0.77997073
51MP0002089_abnormal_postnatal_growth/wei0.77521677
52MP0005670_abnormal_white_adipose0.77516052
53MP0005187_abnormal_penis_morphology0.75939557
54MP0005409_darkened_coat_color0.73906739
55MP0002971_abnormal_brown_adipose0.72533451
56MP0005220_abnormal_exocrine_pancreas0.71722146
57MP0004130_abnormal_muscle_cell0.70239930
58MP0005334_abnormal_fat_pad0.69587477
59MP0003690_abnormal_glial_cell0.68742467
60MP0005535_abnormal_body_temperature0.67793373
61MP0001661_extended_life_span0.66473548
62MP0003329_amyloid_beta_deposits0.64523095
63MP0005266_abnormal_metabolism0.62992737
64MP0009053_abnormal_anal_canal0.62519480
65MP0001324_abnormal_eye_pigmentation0.61958509
66MP0000639_abnormal_adrenal_gland0.60681647
67MP0001986_abnormal_taste_sensitivity0.60270083
68MP0005174_abnormal_tail_pigmentation0.58471947
69MP0005464_abnormal_platelet_physiology0.57468065
70MP0005448_abnormal_energy_balance0.56929921
71MP0001756_abnormal_urination0.56778059
72MP0005075_abnormal_melanosome_morpholog0.56746697
73MP0006035_abnormal_mitochondrial_morpho0.56397680
74MP0002822_catalepsy0.54745277
75MP0002282_abnormal_trachea_morphology0.52636747
76MP0002928_abnormal_bile_duct0.48418723
77MP0008874_decreased_physiological_sensi0.47493381
78MP0005395_other_phenotype0.47211046
79MP0003638_abnormal_response/metabolism_0.46646349
80MP0003879_abnormal_hair_cell0.46627280
81MP0003436_decreased_susceptibility_to0.46179883
82MP0003724_increased_susceptibility_to0.44657560
83MP0002136_abnormal_kidney_physiology0.44347158
84MP0008873_increased_physiological_sensi0.44200133
85MP0003075_altered_response_to0.43585387
86MP0003718_maternal_effect0.43338727
87MP0005197_abnormal_uvea_morphology0.43036058
88MP0004782_abnormal_surfactant_physiolog0.42846745
89MP0004381_abnormal_hair_follicle0.40684494
90MP0003953_abnormal_hormone_level0.40668903
91MP0002837_dystrophic_cardiac_calcinosis0.40582930
92MP0005166_decreased_susceptibility_to0.39951617
93MP0008872_abnormal_physiological_respon0.38873700
94MP0003122_maternal_imprinting0.38758840
95MP0005248_abnormal_Harderian_gland0.38598927
96MP0009672_abnormal_birth_weight0.35604298
97MP0005666_abnormal_adipose_tissue0.35238483
98MP0006082_CNS_inflammation0.35032223
99MP0000579_abnormal_nail_morphology0.34461443
100MP0005167_abnormal_blood-brain_barrier0.33297281
101MP0009115_abnormal_fat_cell0.32831923
102MP0004883_abnormal_blood_vessel0.32698901
103MP0009785_altered_susceptibility_to0.32577949
104MP0008007_abnormal_cellular_replicative0.32252845
105MP0000249_abnormal_blood_vessel0.32250201
106MP0001853_heart_inflammation0.32018287
107MP0005023_abnormal_wound_healing0.32004249
108MP0002796_impaired_skin_barrier0.30386846
109MP0001243_abnormal_dermal_layer0.30270990
110MP0000230_abnormal_systemic_arterial0.30042301
111MP0002970_abnormal_white_adipose0.30001081
112MP0002168_other_aberrant_phenotype0.29987241
113MP0005410_abnormal_fertilization0.29529111
114MP0001944_abnormal_pancreas_morphology0.29492058
115MP0002075_abnormal_coat/hair_pigmentati0.29441165
116MP0001845_abnormal_inflammatory_respons0.29362447
117MP0009384_cardiac_valve_regurgitation0.29064211
118MP0001881_abnormal_mammary_gland0.28261265
119MP0002132_abnormal_respiratory_system0.26013035
120MP0005164_abnormal_response_to0.25174160
121MP0002249_abnormal_larynx_morphology0.24946203
122MP0002090_abnormal_vision0.23518990
123MP0005058_abnormal_lysosome_morphology0.22101420
124MP0003950_abnormal_plasma_membrane0.20616268
125MP0002092_abnormal_eye_morphology0.20382515
126MP0003699_abnormal_female_reproductive0.19594182

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.51448533
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.35756025
3Intrahepatic cholestasis (HP:0001406)7.34049679
4Prolonged partial thromboplastin time (HP:0003645)6.68312864
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.64792600
6Hypobetalipoproteinemia (HP:0003563)6.45880891
7Xanthomatosis (HP:0000991)6.29759290
8Hyperlipoproteinemia (HP:0010980)5.57603831
9Complement deficiency (HP:0004431)5.47665791
10Joint hemorrhage (HP:0005261)4.90105094
11Hypolipoproteinemia (HP:0010981)4.83198017
12Hyperammonemia (HP:0001987)4.57192476
13Abnormality of the common coagulation pathway (HP:0010990)4.55382314
14Epidermoid cyst (HP:0200040)4.52431118
15Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.42134671
16Hyperglycinemia (HP:0002154)4.41621858
17Ketosis (HP:0001946)4.24676762
18Abnormality of methionine metabolism (HP:0010901)4.23435301
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.21780495
20Hypoalphalipoproteinemia (HP:0003233)4.21238577
21Fat malabsorption (HP:0002630)4.15275018
22Abnormality of glutamine family amino acid metabolism (HP:0010902)4.11718622
23Abnormality of aspartate family amino acid metabolism (HP:0010899)4.08178041
24Abnormality of complement system (HP:0005339)3.99694266
25Abnormality of glycine metabolism (HP:0010895)3.88860526
26Abnormality of serine family amino acid metabolism (HP:0010894)3.88860526
27Hyperglycinuria (HP:0003108)3.87256735
28Hypoglycemic coma (HP:0001325)3.84769332
29Abnormality of pyrimidine metabolism (HP:0004353)3.82183725
30Conjugated hyperbilirubinemia (HP:0002908)3.81093885
31Abnormality of the intrinsic pathway (HP:0010989)3.80901473
32Hypercholesterolemia (HP:0003124)3.67191689
33Hyperbilirubinemia (HP:0002904)3.35891176
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.31047528
35Abnormality of fatty-acid metabolism (HP:0004359)3.27132493
36Spontaneous abortion (HP:0005268)3.13154095
37Delayed CNS myelination (HP:0002188)3.11021206
38Steatorrhea (HP:0002570)3.10280289
39Abnormality of nucleobase metabolism (HP:0010932)3.04592932
40Abnormality of serum amino acid levels (HP:0003112)3.03488088
41Hypochromic microcytic anemia (HP:0004840)3.02879714
42Myocardial infarction (HP:0001658)2.99437408
43Hepatocellular carcinoma (HP:0001402)2.98707536
44Ketoacidosis (HP:0001993)2.98412866
45Fair hair (HP:0002286)2.91309957
46Skin nodule (HP:0200036)2.78601496
47Systemic lupus erythematosus (HP:0002725)2.78469766
48Metabolic acidosis (HP:0001942)2.73121102
49Abnormality of purine metabolism (HP:0004352)2.65797536
50Acanthocytosis (HP:0001927)2.64920506
51Osteomalacia (HP:0002749)2.63228867
52Vascular calcification (HP:0004934)2.56410616
53Lethargy (HP:0001254)2.55095024
54Abnormality of dicarboxylic acid metabolism (HP:0010995)2.52344502
55Dicarboxylic aciduria (HP:0003215)2.52344502
56Glomerulonephritis (HP:0000099)2.51866642
57Arthropathy (HP:0003040)2.51342873
58Purpura (HP:0000979)2.50288236
59Hypoglycemic seizures (HP:0002173)2.49893832
60Abnormal gallbladder morphology (HP:0012437)2.47721950
61Reduced antithrombin III activity (HP:0001976)2.47170595
62Mitral stenosis (HP:0001718)2.44634653
63Spastic diplegia (HP:0001264)2.44226876
64Recurrent gram-negative bacterial infections (HP:0005420)2.43232218
65Cholelithiasis (HP:0001081)2.41834210
66Gout (HP:0001997)2.40263218
67Pulmonary embolism (HP:0002204)2.36375428
68Cerebral edema (HP:0002181)2.35956033
69Amyloidosis (HP:0011034)2.35749095
70Abnormal gallbladder physiology (HP:0012438)2.34673821
71Cholecystitis (HP:0001082)2.34673821
72Neonatal onset (HP:0003623)2.34201777
73Irritability (HP:0000737)2.33262330
74Gingival bleeding (HP:0000225)2.29637792
75Cardiovascular calcification (HP:0011915)2.26735898
76Malnutrition (HP:0004395)2.25269595
77Menorrhagia (HP:0000132)2.20399435
78Esophageal varix (HP:0002040)2.20218391
79Sensorimotor neuropathy (HP:0007141)2.14346809
80Thrombophlebitis (HP:0004418)2.13388184
81Pancreatitis (HP:0001733)2.13243596
82Late onset (HP:0003584)2.12269811
83Generalized hypopigmentation of hair (HP:0011358)2.11703108
84Brushfield spots (HP:0001088)2.09769889
85Poikilocytosis (HP:0004447)2.09678202
86Enlarged kidneys (HP:0000105)2.07195312
87Vomiting (HP:0002013)2.03243763
88Hemorrhage of the eye (HP:0011885)2.03003537
89Opisthotonus (HP:0002179)2.02475594
90Hyperinsulinemic hypoglycemia (HP:0000825)2.01493576
91Abnormality of the gallbladder (HP:0005264)2.00896631
92Increased serum ferritin (HP:0003281)1.98617960
93B lymphocytopenia (HP:0010976)1.98613664
94Generalized aminoaciduria (HP:0002909)1.97820524
95Hyperphosphaturia (HP:0003109)1.96980306
96Widely patent fontanelles and sutures (HP:0004492)1.94289255
97Elevated alkaline phosphatase (HP:0003155)1.94029998
98Abnormality of iron homeostasis (HP:0011031)1.93615630
99Neonatal hypoglycemia (HP:0001998)1.91207001
100Abnormality of transition element cation homeostasis (HP:0011030)1.90565075
101Rickets (HP:0002748)1.90305769
102Abnormality of the Achilles tendon (HP:0005109)1.90177176
103Abnormality of alanine metabolism (HP:0010916)1.89737124
104Hyperalaninemia (HP:0003348)1.89737124
105Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.89737124
106Abnormality of urine glucose concentration (HP:0011016)1.86393481
107Glycosuria (HP:0003076)1.86393481
108Abnormality of alkaline phosphatase activity (HP:0004379)1.85071786
109Hypophosphatemic rickets (HP:0004912)1.84334778
110Abnormality of proline metabolism (HP:0010907)1.83495592
111Hydroxyprolinuria (HP:0003080)1.83495592
112Abnormality of B cell number (HP:0010975)1.83315982
113Renal cortical cysts (HP:0000803)1.82780728
114Abnormal cartilage morphology (HP:0002763)1.82004116
115Status epilepticus (HP:0002133)1.81862848
116Elevated hepatic transaminases (HP:0002910)1.80660656
117Abnormal enzyme/coenzyme activity (HP:0012379)1.80059686
118Nephritis (HP:0000123)1.78275521
119Alkalosis (HP:0001948)1.77100462
120Joint swelling (HP:0001386)1.76567980
121Epistaxis (HP:0000421)1.76260404
122Hyperglycemia (HP:0003074)1.73457643
123Reticulocytosis (HP:0001923)1.73227323
124Abnormal urine phosphate concentration (HP:0012599)1.72402303
125Gangrene (HP:0100758)1.67304773
126Increased serum pyruvate (HP:0003542)1.63781741
127Bile duct proliferation (HP:0001408)1.62713856
128Abnormal biliary tract physiology (HP:0012439)1.62713856
129Hypophosphatemia (HP:0002148)1.60768242
130Vaginal fistula (HP:0004320)1.53223675
131Synostosis involving the elbow (HP:0003938)1.50179092
132Humeroradial synostosis (HP:0003041)1.50179092
133Back pain (HP:0003418)1.49755588
134Hypochromic anemia (HP:0001931)1.49560625

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.98974604
2FGFR44.63463468
3SIK14.57662893
4ERN14.42427575
5MAP3K94.30796897
6ARAF3.76880781
7TAOK33.25000232
8INSRR2.95681905
9ERBB42.89186859
10WNK42.61712763
11NLK2.60078788
12MAP2K42.38668652
13PKN22.25826580
14MUSK2.25274720
15MST1R2.07627556
16MAPK111.91628363
17FLT31.87643271
18PIK3CG1.86604465
19KSR21.83089836
20TRIB31.81088141
21TYK21.76660372
22DAPK21.75000653
23PRKCI1.73036978
24LATS11.55614098
25PTK61.48545231
26ABL21.42594935
27FRK1.38987024
28NEK91.38197805
29FGFR21.37601525
30KDR1.27413784
31JAK21.26328451
32MAP3K71.26279379
33GRK61.16858827
34TYRO31.13526991
35PRKAA21.11838942
36MAP3K101.09573488
37JAK11.09011286
38PINK11.08588615
39CSNK1A1L1.08429488
40TBK11.07344366
41MAP2K31.06409254
42ERBB21.03574829
43MAP3K141.02592081
44BRAF1.00890816
45MAPK40.98634469
46PRKCZ0.92180789
47RAF10.90577267
48EPHB10.85008651
49MAPK120.81988084
50CDK60.79777592
51MAP3K30.79294128
52MAP3K110.78573456
53MOS0.78032288
54NTRK30.77990661
55EPHA30.77315808
56TESK20.77073413
57TIE10.77064019
58MET0.76454746
59CAMK1D0.76199128
60PRKACG0.75708248
61MAPK150.75232083
62STK38L0.73796909
63CSNK1D0.73727775
64DYRK1B0.72963150
65CSK0.72336767
66CDK120.71701332
67CAMK2G0.69293784
68SGK30.69218457
69EPHA40.67977260
70IRAK30.67105731
71GSK3A0.64502361
72PRKAA10.63580312
73ADRBK20.63227834
74RIPK10.62739876
75MAP2K60.62596751
76FGFR30.62027806
77CSF1R0.61867926
78FGFR10.59581140
79MAPK70.58544988
80IKBKE0.57868320
81WNK10.56564547
82PDGFRA0.56010781
83PRKCQ0.54740446
84TGFBR20.54375482
85MAP3K130.53516086
86TNK20.53137003
87PDPK10.52652956
88PTK20.52320754
89SGK20.51038194
90JAK30.49906205
91PRKG10.49356960
92ITK0.46417717
93DYRK1A0.45880752
94PRKACA0.45261450
95RET0.44762582
96CSNK1G10.44473076
97TAOK20.43649905
98IGF1R0.43421551
99GRK10.42687123
100MAP3K50.42310302
101PRKCG0.42210974
102MAP2K10.41733387
103AKT30.40682851
104SYK0.40153454
105PKN10.39790494
106CDK40.39767767
107ZAK0.39714282
108LCK0.38832503
109SGK10.38277893
110ZAP700.37414889
111MAPK30.36869521
112MAP3K10.36643051
113CSNK1E0.36623748
114ICK0.35734619
115PDK10.35413710
116CAMK40.34806789
117EGFR0.34664988
118SRC0.34449253
119SGK2230.34058608
120SGK4940.34058608
121MAPK80.33829457
122MTOR0.33662618
123MAP3K60.32145666
124RPS6KA30.31039633
125CAMK1G0.30990549
126ACVR1B0.29409906
127CSNK1A10.27534041
128MAPK10.26501011
129PRKCA0.26236716
130CSNK1G20.25960679
131PRKCB0.25443267
132MAP4K10.23457020
133IRAK10.23110586
134ABL10.22502864
135PIK3CA0.21363348
136PAK30.20713831
137KIT0.20526292
138PBK0.20388238
139IRAK20.19860768
140BMX0.19540773
141CSNK1G30.19538592

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.55056155
2Nitrogen metabolism_Homo sapiens_hsa009103.65445547
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.39003241
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.36305463
5Arginine biosynthesis_Homo sapiens_hsa002203.08568948
6Complement and coagulation cascades_Homo sapiens_hsa046102.82570158
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.69827436
8Tryptophan metabolism_Homo sapiens_hsa003802.69478276
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.62594438
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.53644789
11Fatty acid degradation_Homo sapiens_hsa000712.47980991
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.36344293
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.24825401
14Butanoate metabolism_Homo sapiens_hsa006502.15275736
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.13592932
16Peroxisome_Homo sapiens_hsa041462.06525599
17Chemical carcinogenesis_Homo sapiens_hsa052041.94629044
18Steroid hormone biosynthesis_Homo sapiens_hsa001401.92975048
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.91848308
20Histidine metabolism_Homo sapiens_hsa003401.91162321
21Propanoate metabolism_Homo sapiens_hsa006401.90269201
22PPAR signaling pathway_Homo sapiens_hsa033201.86310584
23Staphylococcus aureus infection_Homo sapiens_hsa051501.80999260
24Fatty acid metabolism_Homo sapiens_hsa012121.79355623
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.77268440
26Caffeine metabolism_Homo sapiens_hsa002321.74796518
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.74787478
28beta-Alanine metabolism_Homo sapiens_hsa004101.70590409
29Retinol metabolism_Homo sapiens_hsa008301.70096407
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.64871757
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.59551858
32Selenocompound metabolism_Homo sapiens_hsa004501.57894308
33Phenylalanine metabolism_Homo sapiens_hsa003601.54640906
34Bile secretion_Homo sapiens_hsa049761.51131058
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.49431697
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.46792301
37Tyrosine metabolism_Homo sapiens_hsa003501.43316863
38Pyruvate metabolism_Homo sapiens_hsa006201.34614628
39Sulfur metabolism_Homo sapiens_hsa009201.32446207
40Fatty acid elongation_Homo sapiens_hsa000621.30345185
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.30147048
42Starch and sucrose metabolism_Homo sapiens_hsa005001.28174922
43ABC transporters_Homo sapiens_hsa020101.22487430
44Folate biosynthesis_Homo sapiens_hsa007901.19383019
45Fat digestion and absorption_Homo sapiens_hsa049751.18752344
46Steroid biosynthesis_Homo sapiens_hsa001001.18571766
47Biosynthesis of amino acids_Homo sapiens_hsa012301.17987742
48Carbon metabolism_Homo sapiens_hsa012001.10554585
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02466347
50Maturity onset diabetes of the young_Homo sapiens_hsa049501.02103635
51Cyanoamino acid metabolism_Homo sapiens_hsa004600.99364752
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.97858645
53Vitamin B6 metabolism_Homo sapiens_hsa007500.96930027
54Arginine and proline metabolism_Homo sapiens_hsa003300.94505031
55Sulfur relay system_Homo sapiens_hsa041220.93910382
56Vitamin digestion and absorption_Homo sapiens_hsa049770.87106030
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86541456
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.85856594
59Lysine degradation_Homo sapiens_hsa003100.81560098
60One carbon pool by folate_Homo sapiens_hsa006700.75101152
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68912298
62Glycerolipid metabolism_Homo sapiens_hsa005610.67528887
63Glutathione metabolism_Homo sapiens_hsa004800.62586169
64Pentose phosphate pathway_Homo sapiens_hsa000300.55041391
65Fatty acid biosynthesis_Homo sapiens_hsa000610.53254062
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44472902
67Metabolic pathways_Homo sapiens_hsa011000.44470628
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43842023
69Prion diseases_Homo sapiens_hsa050200.37327309
70Galactose metabolism_Homo sapiens_hsa000520.26352375
71Other glycan degradation_Homo sapiens_hsa005110.25139077
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24392278
73Insulin resistance_Homo sapiens_hsa049310.24282784
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.22684067
75Fructose and mannose metabolism_Homo sapiens_hsa000510.21936921
76Linoleic acid metabolism_Homo sapiens_hsa005910.19891210
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.16560368
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.15713333
79Glucagon signaling pathway_Homo sapiens_hsa049220.10840555
80Mineral absorption_Homo sapiens_hsa049780.09184164
81AMPK signaling pathway_Homo sapiens_hsa041520.01733426
82Sphingolipid metabolism_Homo sapiens_hsa006000.00657039
83Pertussis_Homo sapiens_hsa05133-0.2448469
84Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2352255
85Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2348659
86Amoebiasis_Homo sapiens_hsa05146-0.2346915
87Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2054421
88Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2047686
89Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1901953
90Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1885251
91Renin-angiotensin system_Homo sapiens_hsa04614-0.1871863
92Lysosome_Homo sapiens_hsa04142-0.1751189
93Hepatitis C_Homo sapiens_hsa05160-0.1706588
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1698898
95Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.1616679
96Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1515269
97Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1502335
98Regulation of autophagy_Homo sapiens_hsa04140-0.1427092
99Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1413590
100Ether lipid metabolism_Homo sapiens_hsa00565-0.1359102
101African trypanosomiasis_Homo sapiens_hsa05143-0.1236431
102Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0928493
103Serotonergic synapse_Homo sapiens_hsa04726-0.0908856
104Insulin signaling pathway_Homo sapiens_hsa04910-0.0892387
105Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0703617
106Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0675484
107Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0663475
108N-Glycan biosynthesis_Homo sapiens_hsa00510-0.0457828
109Primary immunodeficiency_Homo sapiens_hsa05340-0.0248904

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