PRPF18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is found to be essential for the catalytic step II in pre-mRNA splicing process. It is found in the spliceosome, and contains seven WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to the yeast splicing factor Prp18. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of potassium ion transmembrane transporter activity (GO:1901017)9.99888483
2negative regulation of muscle hypertrophy (GO:0014741)9.97560115
3negative regulation of protein localization to cell surface (GO:2000009)9.69273910
4ribonucleoprotein complex disassembly (GO:0032988)9.60863757
5activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO9.16953422
6negative regulation of potassium ion transmembrane transport (GO:1901380)8.76694696
7membrane raft organization (GO:0031579)8.55283144
8negative regulation of organelle assembly (GO:1902116)8.34947364
9negative regulation of cardiac muscle hypertrophy (GO:0010614)8.34100425
10negative regulation of heart growth (GO:0061117)8.32731650
11negative regulation of cardiac muscle tissue growth (GO:0055022)8.32731650
12organelle disassembly (GO:1903008)8.17945807
13negative regulation of monooxygenase activity (GO:0032769)7.44198699
14regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)7.25418497
15negative regulation of cell size (GO:0045792)7.14389516
16positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc7.07622914
17positive regulation of microtubule polymerization (GO:0031116)7.02261028
18positive regulation of myotube differentiation (GO:0010831)6.40950707
19regulation of action potential (GO:0098900)6.36825050
20regulation of p38MAPK cascade (GO:1900744)6.13435081
21negative regulation of cardiac muscle tissue development (GO:0055026)6.05301529
22membrane assembly (GO:0071709)6.03839045
23striated muscle atrophy (GO:0014891)5.75058150
24muscle cell cellular homeostasis (GO:0046716)5.70253451
25regulation of cardiac muscle cell differentiation (GO:2000725)5.36665249
26muscle atrophy (GO:0014889)5.30743350
27negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.19617251
28negative regulation of cell killing (GO:0031342)5.19617251
29primary alcohol catabolic process (GO:0034310)5.02419609
30positive regulation of gamma-delta T cell activation (GO:0046645)4.91942305
31protoporphyrinogen IX metabolic process (GO:0046501)4.87104196
32positive regulation of microtubule polymerization or depolymerization (GO:0031112)4.80820430
33heart trabecula formation (GO:0060347)4.70563529
34cytoplasmic microtubule organization (GO:0031122)4.58101867
35intrinsic apoptotic signaling pathway in response to oxidative stress (GO:0008631)4.57497275
36postreplication repair (GO:0006301)4.55240151
37regulation of membrane repolarization (GO:0060306)4.50493465
38positive regulation of uterine smooth muscle contraction (GO:0070474)4.44425116
39ventricular cardiac muscle cell action potential (GO:0086005)4.39019893
40cardiac myofibril assembly (GO:0055003)4.38937930
41regulation of muscle hypertrophy (GO:0014743)4.37859012
42regulation of alkaline phosphatase activity (GO:0010692)4.35929466
43positive T cell selection (GO:0043368)4.33392466
44negative regulation of potassium ion transport (GO:0043267)4.21552874
45protoporphyrinogen IX biosynthetic process (GO:0006782)4.20006407
46response to muscle activity (GO:0014850)4.19144259
47regulation of transforming growth factor beta2 production (GO:0032909)4.11516614
48polyol biosynthetic process (GO:0046173)4.10579425
49lens fiber cell differentiation (GO:0070306)4.03773312
50regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:24.02782796
51myoblast fusion (GO:0007520)3.98031802
52negative regulation of oxidoreductase activity (GO:0051354)3.97856651
53ER overload response (GO:0006983)3.85847688
54response to pheromone (GO:0019236)3.80921988
55positive thymic T cell selection (GO:0045059)3.75961333
56regulation of gamma-delta T cell differentiation (GO:0045586)3.75611909
57regulation of gamma-delta T cell activation (GO:0046643)3.75458891
58skeletal muscle tissue regeneration (GO:0043403)3.71999882
59negative regulation of organ growth (GO:0046621)3.69326893
60regulation of protein localization to cell surface (GO:2000008)3.67151856
61NADH metabolic process (GO:0006734)3.66641620
62regulation of cardiac muscle hypertrophy (GO:0010611)3.59749846
63protein-cofactor linkage (GO:0018065)3.49633037
64response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.47863581
65serotonin metabolic process (GO:0042428)3.45930074
66negative T cell selection (GO:0043383)3.45527437
67regulation of DNA endoreduplication (GO:0032875)3.43737911
68negative regulation of striated muscle tissue development (GO:0045843)3.42017778
69syncytium formation by plasma membrane fusion (GO:0000768)3.38907259
70negative regulation of muscle tissue development (GO:1901862)3.36026580
71regulation of isotype switching to IgG isotypes (GO:0048302)3.34089690
72regulation of calcium ion import (GO:0090279)3.33306224
73nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)3.33206525
74positive regulation of striated muscle cell differentiation (GO:0051155)3.33093213
75cell fate commitment involved in formation of primary germ layer (GO:0060795)3.32239899
76adenosine metabolic process (GO:0046085)3.29740010
77myofibril assembly (GO:0030239)3.27071416
78activated T cell proliferation (GO:0050798)3.27063162
79regulation of potassium ion transmembrane transporter activity (GO:1901016)3.26786564
80response to inactivity (GO:0014854)3.25420544
81negative regulation of muscle organ development (GO:0048635)3.24800560
82positive regulation of myoblast differentiation (GO:0045663)3.21418785
83positive regulation of transforming growth factor beta production (GO:0071636)3.20695817
84T-helper cell differentiation (GO:0042093)3.16848095
85CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.16848095
86T cell selection (GO:0045058)3.16629730
87pericardium development (GO:0060039)3.14137794
88regulation of uterine smooth muscle contraction (GO:0070472)3.13359636
89negative regulation of B cell proliferation (GO:0030889)3.11408641
90cellular zinc ion homeostasis (GO:0006882)3.08394363
91negative regulation of striated muscle cell differentiation (GO:0051154)3.08017570
92vesicle transport along microtubule (GO:0047496)3.07741174
93positive regulation of extracellular matrix organization (GO:1903055)3.07713781
94positive regulation of cell junction assembly (GO:1901890)3.06559560
95positive regulation of focal adhesion assembly (GO:0051894)3.06559560
96positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.03661825
97regulation of microtubule polymerization (GO:0031113)3.03310511
98dopamine transport (GO:0015872)3.02194986
99interferon-gamma production (GO:0032609)3.02035753
100thymic T cell selection (GO:0045061)3.00123290
101nucleus localization (GO:0051647)2.97517192
102leukocyte aggregation (GO:0070486)2.95122998
103tachykinin receptor signaling pathway (GO:0007217)2.94080640
104response to interleukin-15 (GO:0070672)2.93338476
105detection of calcium ion (GO:0005513)2.93253669
106response to gravity (GO:0009629)2.92933418
107protein K63-linked deubiquitination (GO:0070536)2.92628982
108negative thymic T cell selection (GO:0045060)2.89337018
109skeletal muscle adaptation (GO:0043501)2.88692305
110response to insecticide (GO:0017085)2.88437547
111regulation of membrane depolarization (GO:0003254)2.88389668
112primary amino compound metabolic process (GO:1901160)2.86689819
113DNA deamination (GO:0045006)2.85860319
114behavioral response to nicotine (GO:0035095)2.85451161
115SMAD protein complex assembly (GO:0007183)2.84934876
116regulation of muscle adaptation (GO:0043502)2.84406479
117epithelial cell differentiation involved in kidney development (GO:0035850)2.83758014
118muscle cell fate commitment (GO:0042693)2.82553802
119T cell receptor signaling pathway (GO:0050852)2.80877940
120ethanol metabolic process (GO:0006067)2.80571238
121heart process (GO:0003015)2.80203934
122heart contraction (GO:0060047)2.80203934
123syncytium formation (GO:0006949)2.79358933
124autophagic vacuole fusion (GO:0000046)2.79102287
125negative regulation of T cell mediated immunity (GO:0002710)2.78699020
126positive regulation of skeletal muscle tissue development (GO:0048643)2.78390658
127myotube differentiation (GO:0014902)2.76233609
128positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.75439040
129viral protein processing (GO:0019082)2.74219980
130negative regulation of osteoblast proliferation (GO:0033689)2.72859900
131positive regulation of protein homodimerization activity (GO:0090073)2.71273410
132cell morphogenesis involved in neuron differentiation (GO:0048667)2.70909866
133positive regulation of adherens junction organization (GO:1903393)2.69626030
134T cell differentiation involved in immune response (GO:0002292)2.67791269
135alpha-beta T cell differentiation involved in immune response (GO:0002293)2.67791269
136alpha-beta T cell activation involved in immune response (GO:0002287)2.67791269
137zinc ion homeostasis (GO:0055069)2.66714173
138response to xenobiotic stimulus (GO:0009410)2.63105979
139cellular copper ion homeostasis (GO:0006878)2.63044577
140Golgi transport vesicle coating (GO:0048200)2.62117364
141COPI coating of Golgi vesicle (GO:0048205)2.62117364
142trabecula formation (GO:0060343)2.62008275
143regulation of potassium ion transmembrane transport (GO:1901379)2.61892230
144cardiac muscle cell development (GO:0055013)2.61791944
145embryonic viscerocranium morphogenesis (GO:0048703)2.58821499
146membrane budding (GO:0006900)2.58106056
147regulation of short-term neuronal synaptic plasticity (GO:0048172)2.58071314
148regulation of oxidative phosphorylation (GO:0002082)2.57794459
149metallo-sulfur cluster assembly (GO:0031163)2.57163882
150iron-sulfur cluster assembly (GO:0016226)2.57163882
151positive regulation of mitochondrial fission (GO:0090141)2.56389704
152regulation of oxidative stress-induced neuron death (GO:1903203)2.56137019
153mitotic sister chromatid cohesion (GO:0007064)2.55612405
154lymphocyte costimulation (GO:0031294)2.54633573
155regulation of synaptic vesicle transport (GO:1902803)2.54436879
156catechol-containing compound biosynthetic process (GO:0009713)2.54129470
157catecholamine biosynthetic process (GO:0042423)2.54129470
158transcytosis (GO:0045056)2.52993849
159catecholamine transport (GO:0051937)2.52392219
160regulation of alpha-beta T cell proliferation (GO:0046640)2.52277470
161histone H2A ubiquitination (GO:0033522)2.50211066
162regulation of somitogenesis (GO:0014807)2.50154166
163T cell costimulation (GO:0031295)2.49644323
164regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.49608746
165regulation of acyl-CoA biosynthetic process (GO:0050812)2.48684161
166stress granule assembly (GO:0034063)2.45908736
167positive regulation of B cell differentiation (GO:0045579)2.45190317
168phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.44930946
169negative regulation of lymphocyte mediated immunity (GO:0002707)2.43697048
170protein K48-linked deubiquitination (GO:0071108)2.43497180
171antigen receptor-mediated signaling pathway (GO:0050851)2.41867573
172positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.41722157
173negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.41249260
174detection of bacterium (GO:0016045)2.40951993
175protein K11-linked ubiquitination (GO:0070979)2.37109041
176positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.36412879
177alpha-beta T cell differentiation (GO:0046632)2.36076858
178regulation of B cell receptor signaling pathway (GO:0050855)2.35319844
179T cell activation involved in immune response (GO:0002286)2.33858320
180ER to Golgi vesicle-mediated transport (GO:0006888)2.33053282
181CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.31241624
182regulation of T cell receptor signaling pathway (GO:0050856)2.31030374
183negative regulation of microtubule polymerization (GO:0031115)2.30672724
184organelle membrane fusion (GO:0090174)2.30366406
185regulation of translational termination (GO:0006449)2.28393898
186succinate metabolic process (GO:0006105)2.27542969
187positive regulation of DNA recombination (GO:0045911)2.25950278
188positive regulation of alpha-beta T cell proliferation (GO:0046641)2.25703993
189transferrin transport (GO:0033572)2.24103582
190regulation of isotype switching (GO:0045191)2.24031009
191cerebellar Purkinje cell differentiation (GO:0021702)2.22452256
192monoubiquitinated protein deubiquitination (GO:0035520)2.22042671
193norepinephrine metabolic process (GO:0042415)2.19787562
194regulation of defense response to virus by virus (GO:0050690)2.17721775
195detection of other organism (GO:0098543)2.16445670
196regulation of sarcomere organization (GO:0060297)12.9352448
197plasma membrane repair (GO:0001778)11.2901702
198negative regulation of nitric-oxide synthase activity (GO:0051001)11.0983632
199regulation of skeletal muscle contraction (GO:0014819)10.3922228

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human7.24565808
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse7.08203483
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.31639235
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.31639235
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.31639235
6ZNF274_21170338_ChIP-Seq_K562_Hela4.29578548
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.54598439
8GATA1_22025678_ChIP-Seq_K562_Human3.21005547
9IGF1R_20145208_ChIP-Seq_DFB_Human3.20973433
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.95151075
11TAF15_26573619_Chip-Seq_HEK293_Human2.77335277
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.58355181
13* GABP_17652178_ChIP-ChIP_JURKAT_Human2.36075240
14FUS_26573619_Chip-Seq_HEK293_Human2.18199167
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.15704048
16BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.15053276
17RUNX1_17652178_ChIP-ChIP_JURKAT_Human2.12816917
18* VDR_23849224_ChIP-Seq_CD4+_Human2.09977328
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.08873341
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.07456226
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.00834640
22* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.98336393
23PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96725420
24DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.92552261
25FOXM1_23109430_ChIP-Seq_U2OS_Human1.88626048
26* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.87375229
27IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.85761525
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.85015440
29* ELK1_19687146_ChIP-ChIP_HELA_Human1.84044897
30HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.82008461
31RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.80347585
32E2F7_22180533_ChIP-Seq_HELA_Human1.76376772
33SRF_21415370_ChIP-Seq_HL-1_Mouse1.75460123
34ELF1_17652178_ChIP-ChIP_JURKAT_Human1.74493136
35PADI4_21655091_ChIP-ChIP_MCF-7_Human1.69673740
36STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.68318008
37PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.65187523
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.62679591
39SALL1_21062744_ChIP-ChIP_HESCs_Human1.62157566
40CIITA_25753668_ChIP-Seq_RAJI_Human1.59618963
41* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.55660113
42MYB_26560356_Chip-Seq_TH2_Human1.55459843
43KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.54308984
44NOTCH1_21737748_ChIP-Seq_TLL_Human1.51783572
45* ETS1_20019798_ChIP-Seq_JURKAT_Human1.51418306
46* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.51318423
47RUNX_20019798_ChIP-Seq_JUKART_Human1.50607244
48* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.48451240
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47015538
50* FOXP3_21729870_ChIP-Seq_TREG_Human1.42186313
51EWS_26573619_Chip-Seq_HEK293_Human1.40501924
52E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.39683491
53EGR1_19374776_ChIP-ChIP_THP-1_Human1.37193341
54SMAD_19615063_ChIP-ChIP_OVARY_Human1.34379012
55HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.32225074
56PCGF2_27294783_Chip-Seq_ESCs_Mouse1.29563676
57AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27334072
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.26256075
59* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.26174856
60MYB_26560356_Chip-Seq_TH1_Human1.25355585
61PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.25269154
62NR3C1_23031785_ChIP-Seq_PC12_Mouse1.24193119
63KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.23651237
64E2F4_17652178_ChIP-ChIP_JURKAT_Human1.23582632
65CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.23007980
66CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.22216196
67ZFP57_27257070_Chip-Seq_ESCs_Mouse1.21018118
68GATA3_27048872_Chip-Seq_THYMUS_Human1.18546527
69CREB1_15753290_ChIP-ChIP_HEK293T_Human1.18007030
70JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.17980682
71EZH2_27294783_Chip-Seq_NPCs_Mouse1.16984016
72ER_23166858_ChIP-Seq_MCF-7_Human1.16596943
73* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16085540
74IRF8_22096565_ChIP-ChIP_GC-B_Human1.16066060
75KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15674207
76NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.14258149
77ERG_20517297_ChIP-Seq_VCAP_Human1.13773846
78* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13385223
79CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12448159
80PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.12361274
81* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12288610
82* NANOG_18555785_Chip-Seq_ESCs_Mouse1.11613260
83NMYC_18555785_Chip-Seq_ESCs_Mouse1.10686154
84* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.10298886
85TRIM28_21343339_ChIP-Seq_HEK293_Human1.10046979
86SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09436589
87SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.09362368
88GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.05075190
89GATA3_26560356_Chip-Seq_TH1_Human1.04585488
90SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.03866954
91EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03592633
92MYB_21317192_ChIP-Seq_ERMYB_Mouse1.03100054
93AUTS2_25519132_ChIP-Seq_293T-REX_Human1.02616540
94CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02333959
95NFE2_27457419_Chip-Seq_LIVER_Mouse1.01826057
96CTBP2_25329375_ChIP-Seq_LNCAP_Human1.01817041
97GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01140087
98EGR1_23403033_ChIP-Seq_LIVER_Mouse1.01038312
99* CJUN_26792858_Chip-Seq_BT549_Human0.99918645
100POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.99885875
101FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.99878939
102RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99249596
103LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.98583898
104ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.97849615
105CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.97242606
106* P300_18555785_Chip-Seq_ESCs_Mouse0.97117647
107EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97051305
108* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.96544191
109KDM5A_27292631_Chip-Seq_BREAST_Human0.96421184
110GATA3_26560356_Chip-Seq_TH2_Human0.95727932
111GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.95566050
112CDX2_22108803_ChIP-Seq_LS180_Human0.95336824
113* E2F1_18555785_Chip-Seq_ESCs_Mouse0.94781858
114* SOX2_18555785_Chip-Seq_ESCs_Mouse0.94767288
115TFEB_21752829_ChIP-Seq_HELA_Human0.94231851
116* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93585617
117PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93570511
118SUZ12_18555785_Chip-Seq_ESCs_Mouse0.93526092
119SALL4_22934838_ChIP-ChIP_CD34+_Human0.93210948
120* P53_22387025_ChIP-Seq_ESCs_Mouse0.93106851
121CTBP1_25329375_ChIP-Seq_LNCAP_Human0.93053318
122STAT3_18555785_Chip-Seq_ESCs_Mouse0.92744757
123THAP11_20581084_ChIP-Seq_MESCs_Mouse0.92631263
124E2F1_21310950_ChIP-Seq_MCF-7_Human0.92127550
125ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.91618910
126GATA1_19941827_ChIP-Seq_MEL_Mouse0.91515188
127ESR1_20079471_ChIP-ChIP_T-47D_Human0.91367143
128MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.91083544
129* CTCF_18555785_Chip-Seq_ESCs_Mouse0.90620306
130* ELK1_22589737_ChIP-Seq_MCF10A_Human0.90327993
131* TAL1_26923725_Chip-Seq_HPCs_Mouse0.89657646
132SPI1_20517297_ChIP-Seq_HL60_Human0.88850851
133OCT4_21477851_ChIP-Seq_ESCs_Mouse0.88846067
134UTX_26944678_Chip-Seq_JUKART_Human0.88545205
135BCAT_22108803_ChIP-Seq_LS180_Human0.87960567
136* STAT4_19710469_ChIP-ChIP_TH1__Mouse0.87111097
137* RUNX1_27457419_Chip-Seq_LIVER_Mouse0.86821355
138REST_19997604_ChIP-ChIP_NEURONS_Mouse0.86727024
139GBX2_23144817_ChIP-Seq_PC3_Human0.86472870
140* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.85621859
141* OCT4_18555785_Chip-Seq_ESCs_Mouse0.85558600
142GATA2_22383799_ChIP-Seq_G1ME_Mouse0.85222485
143P300_19829295_ChIP-Seq_ESCs_Human0.85215978
144SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.85192695
145* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.85113962
146ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.83859598
147* BRD4_25478319_ChIP-Seq_HGPS_Human0.83722569
148TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.82906983
149NCOR_22424771_ChIP-Seq_293T_Human0.82784047
150TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.78983285
151FOXA1_21572438_ChIP-Seq_LNCaP_Human0.78856743
152AR_20517297_ChIP-Seq_VCAP_Human0.78689365
153ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.76717400
154TDRD3_21172665_ChIP-Seq_MCF-7_Human0.76597380

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000749_muscle_degeneration5.85526240
2MP0002102_abnormal_ear_morphology5.55448311
3MP0003656_abnormal_erythrocyte_physiolo4.29839764
4MP0000751_myopathy4.26956749
5MP0003183_abnormal_peptide_metabolism3.58972609
6MP0004084_abnormal_cardiac_muscle3.58630944
7MP0002138_abnormal_hepatobiliary_system3.33699372
8MP0005645_abnormal_hypothalamus_physiol2.91536436
9MP0005671_abnormal_response_to2.53374033
10MP0003763_abnormal_thymus_physiology2.47004095
11MP0003693_abnormal_embryo_hatching2.23162083
12MP0008789_abnormal_olfactory_epithelium2.20138860
13MP0010234_abnormal_vibrissa_follicle2.16535195
14MP0001529_abnormal_vocalization2.15099152
15MP0003724_increased_susceptibility_to2.10932877
16MP0000750_abnormal_muscle_regeneration2.05357315
17MP0005330_cardiomyopathy2.00133501
18MP0003950_abnormal_plasma_membrane12.2408466
19MP0004036_abnormal_muscle_relaxation1.90943346
20MP0004147_increased_porphyrin_level1.90722590
21MP0003303_peritoneal_inflammation1.84046630
22MP0004145_abnormal_muscle_electrophysio1.82759323
23MP0005646_abnormal_pituitary_gland1.79597282
24MP0005083_abnormal_biliary_tract1.78735014
25MP0002269_muscular_atrophy1.76575113
26MP0002277_abnormal_respiratory_mucosa1.71515298
27MP0009697_abnormal_copulation1.69937467
28MP0006276_abnormal_autonomic_nervous1.59354372
29MP0001984_abnormal_olfaction1.56176606
30MP0005499_abnormal_olfactory_system1.55016776
31MP0005394_taste/olfaction_phenotype1.55016776
32MP0003806_abnormal_nucleotide_metabolis1.50224844
33MP0003787_abnormal_imprinting1.50058893
34MP0004883_abnormal_blood_vessel1.49862393
35MP0008057_abnormal_DNA_replication1.48425447
36MP0003252_abnormal_bile_duct1.46583172
37MP0005387_immune_system_phenotype1.46127714
38MP0001790_abnormal_immune_system1.46127714
39MP0002132_abnormal_respiratory_system1.46087872
40MP0008260_abnormal_autophagy1.45752018
41MP0005379_endocrine/exocrine_gland_phen1.43847757
42MP0001542_abnormal_bone_strength1.43800271
43MP0002106_abnormal_muscle_physiology1.43754980
44MP0002972_abnormal_cardiac_muscle1.40848065
45MP0002909_abnormal_adrenal_gland1.39379456
46MP0005187_abnormal_penis_morphology1.39094264
47MP0002398_abnormal_bone_marrow1.38824635
48MP0000759_abnormal_skeletal_muscle1.35281450
49MP0004782_abnormal_surfactant_physiolog1.34693274
50MP0001800_abnormal_humoral_immune1.34526398
51MP0008872_abnormal_physiological_respon1.31010888
52MP0001293_anophthalmia1.30448558
53MP0000569_abnormal_digit_pigmentation1.30390560
54MP0003786_premature_aging1.28744628
55MP0003868_abnormal_feces_composition1.26148644
56MP0005310_abnormal_salivary_gland1.25789395
57MP0002837_dystrophic_cardiac_calcinosis1.25338218
58MP0001853_heart_inflammation1.24961823
59MP0000685_abnormal_immune_system1.24273426
60MP0004272_abnormal_basement_membrane1.24059205
61MP0001764_abnormal_homeostasis1.23729192
62MP0002877_abnormal_melanocyte_morpholog1.23606495
63MP0005085_abnormal_gallbladder_physiolo1.23112245
64MP0002638_abnormal_pupillary_reflex1.22152317
65MP0002420_abnormal_adaptive_immunity1.21904604
66MP0001819_abnormal_immune_cell1.19437040
67MP0005365_abnormal_bile_salt1.19208439
68MP0000703_abnormal_thymus_morphology1.18266731
69MP0005636_abnormal_mineral_homeostasis1.18248789
70MP0002006_tumorigenesis1.17538227
71MP0006292_abnormal_olfactory_placode1.17466693
72MP0005620_abnormal_muscle_contractility1.16131716
73MP0001873_stomach_inflammation1.15304184
74MP0002405_respiratory_system_inflammati1.14894602
75MP0004087_abnormal_muscle_fiber1.14519398
76MP0005360_urolithiasis1.13744474
77MP0003122_maternal_imprinting1.12330168
78MP0003300_gastrointestinal_ulcer1.12309095
79MP0002139_abnormal_hepatobiliary_system1.11672936
80MP0002693_abnormal_pancreas_physiology1.10157123
81MP0005386_behavior/neurological_phenoty1.10012532
82MP0004924_abnormal_behavior1.10012532
83MP0005369_muscle_phenotype1.09554195
84MP0004270_analgesia1.08478211
85MP0008775_abnormal_heart_ventricle1.08280224
86MP0000716_abnormal_immune_system1.07990747
87MP0008058_abnormal_DNA_repair1.07093057
88MP0000689_abnormal_spleen_morphology1.06866264
89MP0002723_abnormal_immune_serum1.06420846
90MP0005408_hypopigmentation1.06118190
91MP0010368_abnormal_lymphatic_system1.05429576
92MP0000013_abnormal_adipose_tissue1.04858249
93MP0002064_seizures1.04633133
94MP0003221_abnormal_cardiomyocyte_apopto1.04205620
95MP0002722_abnormal_immune_system1.04092373
96MP0000467_abnormal_esophagus_morphology1.03588156
97MP0004215_abnormal_myocardial_fiber1.03206718
98MP0002166_altered_tumor_susceptibility1.01390816
99MP0003111_abnormal_nucleus_morphology1.00192514
100MP0003866_abnormal_defecation0.99492987
101MP0001879_abnormal_lymphatic_vessel0.98539597
102MP0005220_abnormal_exocrine_pancreas0.97910369
103MP0005084_abnormal_gallbladder_morpholo0.95310054
104MP0001485_abnormal_pinna_reflex0.94745013
105MP0002452_abnormal_antigen_presenting0.93532879
106MP0002429_abnormal_blood_cell0.91904933
107MP0001440_abnormal_grooming_behavior0.91156575
108MP0000465_gastrointestinal_hemorrhage0.91014915
109MP0002332_abnormal_exercise_endurance0.90986559
110MP0009780_abnormal_chondrocyte_physiolo0.90879642
111MP0004130_abnormal_muscle_cell0.90057289
112MP0000372_irregular_coat_pigmentation0.89030720
113MP0008875_abnormal_xenobiotic_pharmacok0.88795921
114MP0009765_abnormal_xenobiotic_induced0.88791562
115MP0003121_genomic_imprinting0.88535996
116MP0003646_muscle_fatigue0.88100272
117MP0002572_abnormal_emotion/affect_behav0.88070813
118MP0000604_amyloidosis0.87985691
119MP0003635_abnormal_synaptic_transmissio0.87745783
120MP0006036_abnormal_mitochondrial_physio0.86848936
121MP0005385_cardiovascular_system_phenoty0.86302691
122MP0001544_abnormal_cardiovascular_syste0.86302691
123MP0003879_abnormal_hair_cell0.86136803
124MP0004484_altered_response_of0.85718883
125MP0003186_abnormal_redox_activity0.85667354
126MP0010386_abnormal_urinary_bladder0.85616673
127MP0009745_abnormal_behavioral_response0.84347758
128MP0002736_abnormal_nociception_after0.84046583
129MP0002009_preneoplasia0.82386259
130MP0009785_altered_susceptibility_to0.81895852
131MP0010630_abnormal_cardiac_muscle0.81881798
132MP0005000_abnormal_immune_tolerance0.81636858
133MP0002876_abnormal_thyroid_physiology0.81490897
134MP0009046_muscle_twitch0.80422844
135MP0002163_abnormal_gland_morphology0.80389351
136MP0001835_abnormal_antigen_presentation0.79796494
137MP0002063_abnormal_learning/memory/cond0.78116427
138MP0005623_abnormal_meninges_morphology0.77500494
139MP0004859_abnormal_synaptic_plasticity0.76898719
140MP0005171_absent_coat_pigmentation0.76522923
141MP0001944_abnormal_pancreas_morphology0.76360373
142MP0003195_calcinosis0.75893105
143MP0001756_abnormal_urination0.75366565
144MP0004957_abnormal_blastocyst_morpholog0.74936223
145MP0002928_abnormal_bile_duct0.74138838
146MP0003436_decreased_susceptibility_to0.73828818
147MP0002822_catalepsy0.72640453
148MP0002127_abnormal_cardiovascular_syste0.72140355
149MP0003828_pulmonary_edema0.71850989
150MP0001177_atelectasis0.71415175
151MP0003077_abnormal_cell_cycle0.71286681
152MP0002095_abnormal_skin_pigmentation0.70444605
153MP0005319_abnormal_enzyme/_coenzyme0.67691777
154MP0000733_abnormal_muscle_development0.67321071
155MP0005166_decreased_susceptibility_to0.65551943
156MP0000678_abnormal_parathyroid_gland0.65053059
157MP0010094_abnormal_chromosome_stability0.64483620
158MP0005164_abnormal_response_to0.64258621
159MP0003045_fibrosis0.61964685
160MP0001270_distended_abdomen0.60899611
161MP0000427_abnormal_hair_cycle0.60661884
162MP0002933_joint_inflammation0.60495542
163MP0008995_early_reproductive_senescence0.60427704
164MP0000647_abnormal_sebaceous_gland0.56199149
165MP0003453_abnormal_keratinocyte_physiol0.54787259
166MP0002108_abnormal_muscle_morphology0.54488273
167MP0002234_abnormal_pharynx_morphology0.51809897
168MP0002160_abnormal_reproductive_system0.47652010
169MP0002148_abnormal_hypersensitivity_rea0.47353098
170MP0003191_abnormal_cellular_cholesterol0.47165650
171MP0005023_abnormal_wound_healing0.43949770
172MP0002089_abnormal_postnatal_growth/wei0.43446781
173MP0005389_reproductive_system_phenotype0.42838998
174MP0002896_abnormal_bone_mineralization0.40346652
175MP0005376_homeostasis/metabolism_phenot0.38520668
176MP0000681_abnormal_thyroid_gland0.38132240
177MP0001664_abnormal_digestion0.37931583
178MP0003718_maternal_effect0.36451922
179MP0001919_abnormal_reproductive_system0.35100614

Predicted human phenotypes

RankGene SetZ-score
1Muscle hypertrophy of the lower extremities (HP:0008968)9.74634806
2Exercise-induced muscle cramps (HP:0003710)9.37438809
3Abnormality of the left ventricular outflow tract (HP:0011103)9.22956058
4Subaortic stenosis (HP:0001682)9.22956058
5Exercise-induced myalgia (HP:0003738)9.05829788
6Asymmetric septal hypertrophy (HP:0001670)7.12246246
7Renal cortical cysts (HP:0000803)6.19849266
8Muscle stiffness (HP:0003552)5.81916518
9Sudden death (HP:0001699)5.78932874
10Myotonia (HP:0002486)5.70542479
11Abnormality of the calf musculature (HP:0001430)4.76874433
12Arterial tortuosity (HP:0005116)4.49391975
13Increased serum pyruvate (HP:0003542)4.13248110
14Prolonged QT interval (HP:0001657)4.12663501
15Abnormal hair whorl (HP:0010721)4.03094675
16Distal lower limb muscle weakness (HP:0009053)4.00011312
17Neck muscle weakness (HP:0000467)3.99053188
18Hypothermia (HP:0002045)3.95649615
19Vascular tortuosity (HP:0004948)3.90954318
20Gowers sign (HP:0003391)3.63344551
21Hypochromic microcytic anemia (HP:0004840)3.56642600
22Hyperactive renin-angiotensin system (HP:0000841)3.51938681
23Abnormality of the renal cortex (HP:0011035)3.51702026
24Decreased circulating renin level (HP:0003351)3.50796968
25Chronic bronchitis (HP:0004469)3.46339196
26Abnormality of glycolysis (HP:0004366)3.42653075
27Brushfield spots (HP:0001088)3.28312739
28Conjugated hyperbilirubinemia (HP:0002908)3.26998794
29Abnormality of the heme biosynthetic pathway (HP:0010472)3.22345806
30Atonic seizures (HP:0010819)3.21223938
31Turricephaly (HP:0000262)3.21132979
32Hyponatremia (HP:0002902)3.18094111
33Palpebral edema (HP:0100540)3.16665661
34Type 2 muscle fiber atrophy (HP:0003554)3.13701501
35Poikilocytosis (HP:0004447)3.09628804
36Hypokalemic alkalosis (HP:0001949)3.04873372
37Rimmed vacuoles (HP:0003805)3.03767754
38Limb hypertonia (HP:0002509)3.01776954
39Failure to thrive in infancy (HP:0001531)3.01106977
40Spontaneous hematomas (HP:0007420)3.01062365
41Abnormal cartilage morphology (HP:0002763)2.96757857
42Visual hallucinations (HP:0002367)2.96360378
43Spondylolisthesis (HP:0003302)2.89990490
44T lymphocytopenia (HP:0005403)2.78916844
45Abnormal gallbladder morphology (HP:0012437)2.78261468
46Volvulus (HP:0002580)2.78175689
47Ventricular arrhythmia (HP:0004308)2.77098164
48Aplasia/Hypoplasia of the thymus (HP:0010515)2.76430519
49Cholelithiasis (HP:0001081)2.73861788
50Thyroid-stimulating hormone excess (HP:0002925)2.71167559
51Absence seizures (HP:0002121)2.69728506
52Shoulder girdle muscle weakness (HP:0003547)2.67559446
53Hyperkalemia (HP:0002153)2.63963842
54Muscle fiber atrophy (HP:0100295)2.63719240
55Hyperaldosteronism (HP:0000859)2.62870590
56Skin nodule (HP:0200036)2.60932181
57Hyperglycemia (HP:0003074)2.60407761
58Hyporeflexia of lower limbs (HP:0002600)2.60340911
59Abnormality of T cell number (HP:0011839)2.60044893
60Aortic aneurysm (HP:0004942)2.59979250
61Focal motor seizures (HP:0011153)2.59528143
62Hypoplasia of the thymus (HP:0000778)2.59126226
63Dialeptic seizures (HP:0011146)2.59077563
64Osteomalacia (HP:0002749)2.48189331
65Clitoromegaly (HP:0000057)2.47178228
66Acanthocytosis (HP:0001927)2.46169457
67Hepatosplenomegaly (HP:0001433)2.34541233
68Limb dystonia (HP:0002451)2.31509520
69Abnormality of placental membranes (HP:0011409)2.26897971
70Amniotic constriction ring (HP:0009775)2.26897971
71Abnormality of alanine metabolism (HP:0010916)2.26298003
72Hyperalaninemia (HP:0003348)2.26298003
73Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.26298003
74Increased serum ferritin (HP:0003281)2.25338811
75Febrile seizures (HP:0002373)2.24496426
76Abnormality of the fingertips (HP:0001211)2.21812575
77Hyperbilirubinemia (HP:0002904)2.20689301
78Increased corneal curvature (HP:0100692)2.20427990
79Keratoconus (HP:0000563)2.20427990
80Abnormality of sodium homeostasis (HP:0010931)2.20173262
81Hypochromic anemia (HP:0001931)2.18663373
82Microcytic anemia (HP:0001935)2.17468719
83IgG deficiency (HP:0004315)2.17018533
84Abnormal EKG (HP:0003115)2.16103417
85Abnormal biliary tract morphology (HP:0012440)2.15682390
86Pelvic girdle muscle weakness (HP:0003749)2.15542117
87Abnormality of iron homeostasis (HP:0011031)2.15028080
88Posterior subcapsular cataract (HP:0007787)2.13492052
89Hypokalemia (HP:0002900)2.11944481
90Abnormality of the thymus (HP:0000777)2.11422011
91Reticulocytosis (HP:0001923)2.09271368
92Metatarsus adductus (HP:0001840)2.07807251
93Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.06733272
94Papilledema (HP:0001085)2.06695274
95Death in childhood (HP:0003819)2.05938981
96Drooling (HP:0002307)2.05494963
97Excessive salivation (HP:0003781)2.05494963
98Bronchitis (HP:0012387)2.05285763
99Popliteal pterygium (HP:0009756)2.05143128
100Aortic regurgitation (HP:0001659)2.03856436
101Insulin-resistant diabetes mellitus (HP:0000831)2.02520114
102Hypoglycemic seizures (HP:0002173)2.01591983
103Focal seizures (HP:0007359)2.00462203
104Calf muscle hypertrophy (HP:0008981)10.9014380
105Recurrent abscess formation (HP:0002722)1.98258030
106Fatigable weakness (HP:0003473)1.97747299
107Abnormality of the neuromuscular junction (HP:0003398)1.97747299
108Fair hair (HP:0002286)1.94018331
109Abnormality of the labia minora (HP:0012880)1.94001641
110Hepatocellular necrosis (HP:0001404)1.92523542
111Severe combined immunodeficiency (HP:0004430)1.90791235
112Areflexia of lower limbs (HP:0002522)1.90023097
113Hyperthyroidism (HP:0000836)1.90020201
114Pancreatic islet-cell hyperplasia (HP:0004510)1.89967957
115Pili torti (HP:0003777)1.89591903
116Pustule (HP:0200039)1.89566387
117Aortic dissection (HP:0002647)1.89067422
118Oligomenorrhea (HP:0000876)1.89000530
119Abnormal pupillary function (HP:0007686)1.88437278
120Submucous cleft hard palate (HP:0000176)1.88000505
121IgM deficiency (HP:0002850)1.85476257
122Epileptiform EEG discharges (HP:0011182)1.84008521
123EEG with generalized epileptiform discharges (HP:0011198)1.83981527
124Abnormality of transition element cation homeostasis (HP:0011030)1.83153277
125Gout (HP:0001997)1.81865896
126Combined immunodeficiency (HP:0005387)1.81837805
127B lymphocytopenia (HP:0010976)1.81640683
128Absent rod-and cone-mediated responses on ERG (HP:0007688)1.81501984
129Exotropia (HP:0000577)1.81387068
130Hypotension (HP:0002615)1.81036851
131Cubitus valgus (HP:0002967)1.80611925
132Abnormality of the hip-girdle musculature (HP:0001445)1.80212249
133Abnormality of the musculature of the pelvis (HP:0001469)1.80212249
134Progressive inability to walk (HP:0002505)1.79989325
135Chronic diarrhea (HP:0002028)1.79598298
136Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.79187615
137Hepatic necrosis (HP:0002605)1.78498277
138Menstrual irregularities (HP:0000858)1.77483865
139Constricted visual fields (HP:0001133)1.76787686
140Dry hair (HP:0011359)1.76531899
141Abnormality of the pancreatic islet cells (HP:0006476)1.76395336
142Abnormality of endocrine pancreas physiology (HP:0012093)1.76395336
143Thyroiditis (HP:0100646)1.76040934
144Ridged nail (HP:0001807)1.75518932
145Abnormal gallbladder physiology (HP:0012438)1.75427058
146Cholecystitis (HP:0001082)1.75427058
147Poor suck (HP:0002033)1.75310028
148Curly hair (HP:0002212)1.74555859
149Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.73192185
150Weak cry (HP:0001612)1.71408658
151Entropion (HP:0000621)1.70336180
152Lower limb muscle weakness (HP:0007340)1.69797749
153Hypsarrhythmia (HP:0002521)1.69426504
154Dysautonomia (HP:0002459)1.68743041
155Overlapping toe (HP:0001845)1.68462247
156Generalized tonic-clonic seizures (HP:0002069)1.67982957
157Oral leukoplakia (HP:0002745)1.67614748
158Sensorimotor neuropathy (HP:0007141)1.67388916
159Panhypogammaglobulinemia (HP:0003139)1.66789419
160Nemaline bodies (HP:0003798)1.66437726
161Cellular immunodeficiency (HP:0005374)1.65526390
162Delusions (HP:0000746)1.64436918
163Renal salt wasting (HP:0000127)1.64115184
164Protrusio acetabuli (HP:0003179)1.63533737
165Left ventricular hypertrophy (HP:0001712)1.63291382
166Hip dysplasia (HP:0001385)1.61107834
167Hypogonadotrophic hypogonadism (HP:0000044)1.60650355
168Abnormality of the clitoris (HP:0000056)1.59449371
169Abnormality of B cell number (HP:0010975)1.55198933
170Tubulointerstitial nephritis (HP:0001970)1.54968695
171Abnormality of the intervertebral disk (HP:0005108)1.53777719
172Reduced subcutaneous adipose tissue (HP:0003758)1.50787033
173Hamartoma of the eye (HP:0010568)1.47714882
174Childhood onset (HP:0011463)1.47221108
175Aplastic anemia (HP:0001915)1.44723129
176Rhabdomyolysis (HP:0003201)1.44582542
177Meningioma (HP:0002858)1.42893316
178Difficulty walking (HP:0002355)1.42583375
179Striae distensae (HP:0001065)1.42305213
180Prostate neoplasm (HP:0100787)1.42070125
181Palpitations (HP:0001962)1.40254903
182Mitochondrial inheritance (HP:0001427)1.39394483
183Tinnitus (HP:0000360)1.38355151
184Acute necrotizing encephalopathy (HP:0006965)1.34724980
185Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.34531334
186Anhidrosis (HP:0000970)1.33754590
187Periorbital edema (HP:0100539)1.30134504
188Increased CSF lactate (HP:0002490)1.29929829
189Inability to walk (HP:0002540)1.27462366
190Nonprogressive disorder (HP:0003680)1.26391507
191Progressive macrocephaly (HP:0004481)1.24570394
192Facial edema (HP:0000282)1.23444761
193Muscle fiber inclusion bodies (HP:0100299)1.23360152

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPKAPK57.17921668
2CDK85.77305267
3MUSK5.37562007
4SCYL23.78197508
5TSSK63.67153192
6MAP4K13.28637642
7WNK33.22772842
8TXK3.21119933
9MAP3K123.19554570
10PIK3CG3.09160355
11EIF2AK32.85797274
12TLK12.85368973
13TAOK32.70892081
14LMTK22.43132807
15INSRR2.40160447
16DMPK2.38363478
17CDK92.32887730
18FRK2.19559212
19EIF2AK12.17978730
20STK162.07750395
21CCNB12.02207655
22ITK1.95671922
23TYK21.84562638
24SRPK11.80928414
25MAP3K71.79890183
26MOS1.78568346
27ZAP701.63014420
28MAP3K131.62589716
29GRK61.61864131
30TEC1.57442703
31CDK41.50273566
32PAK61.46928663
33SGK21.40547158
34IRAK41.38555923
35NLK1.37958764
36PIK3CA1.32159837
37PLK21.25292476
38ZAK1.24905820
39PLK31.21201188
40GRK51.18379029
41NUAK11.17603482
42SGK31.17190235
43JAK21.16824721
44KSR21.15270109
45VRK11.13221395
46MST41.07826567
47MAPK111.04979932
48BMPR1B1.01414685
49VRK20.99092996
50KSR10.98727967
51JAK30.97061387
52STK240.93979545
53MAP2K70.93546113
54MAPK130.92361703
55CSNK1G30.92239767
56TRIM280.89805946
57PRKCH0.88280186
58FGFR40.86010426
59DYRK30.85855865
60OBSCN0.84943683
61STK100.83943876
62MAPK70.83831303
63FGFR20.83778337
64PRKACB0.83754837
65PBK0.82480148
66EEF2K0.81323653
67SYK0.81076549
68CSNK1D0.80389874
69CSNK1G20.79723400
70GRK70.79701672
71JAK10.78617562
72AKT30.77045978
73SGK2230.76922968
74SGK4940.76922968
75FLT30.76173267
76MAP3K10.75461161
77PRKCQ0.75419116
78RAF10.75360596
79MAP3K40.73429010
80CASK0.73323787
81RPS6KB10.72748109
82CLK10.71942763
83SIK20.70816894
84DAPK20.68909001
85MAP4K20.66457406
86GRK10.63889527
87CAMK2D0.63014702
88CAMKK20.61833992
89IKBKB0.56274269
90PAK20.56192729
91CDK30.56176978
92PKN10.55843823
93BUB10.55719314
94RET0.54637295
95HIPK20.54512970
96DAPK10.54320651
97TAF10.53890358
98SIK30.52404429
99MYLK0.51990768
100PASK0.51718635
101BRSK20.51153807
102ABL10.50818328
103PDK10.50190524
104ERBB40.49060302
105FGFR30.47902641
106FGFR10.47740402
107STK40.47196146
108LCK0.47154084
109MELK0.47018198
110PTK2B0.46627009
111PRKAA10.46598400
112DYRK1A0.45952043
113CDK60.45106845
114CSNK1A1L0.45056539
115DYRK1B0.44810722
116IRAK20.43960579
117IKBKE0.43166185
118CSNK1G10.42890690
119AURKA0.41519465
120STK30.41339187
121FGR0.40861788
122PIM20.40291394
123NTRK30.40068176
124FES0.39234238
125PIM10.39198414
126TBK10.38108244
127MAPKAPK30.37203790
128NEK60.37156691
129BCR0.37153445
130ADRBK20.35794451
131MAPK120.35454820
132TNK20.35365188
133CSNK2A20.35364271
134BRSK10.34679725
135PINK10.34646194
136EIF2AK20.33562450
137STK38L0.33515783
138CAMK2G0.33230662
139IGF1R0.32551170
140EGFR0.32535376
141NME10.32529241
142BRAF0.32228550
143CDC70.31024938
144MAPK40.30664366
145FER0.29869056
146MAP3K110.29632992
147RIPK40.29528172
148LYN0.29447808
149PRKCE0.29226733
150AURKB0.28442710
151NTRK20.28211002
152TGFBR20.27607836
153CSNK2A10.27311074
154HCK0.24805294
155ERBB30.24691857
156NEK10.23452289
157MARK20.22606545
158PRKCG0.22341172
159RPS6KA50.22150101
160CAMK2A0.20130975
161CAMK2B0.19118826
162CSF1R0.18894757
163MAP3K100.18587008
164RPS6KA40.17681821

Predicted pathways (KEGG)

RankGene SetZ-score
1Pyruvate metabolism_Homo sapiens_hsa006203.23832701
2Primary immunodeficiency_Homo sapiens_hsa053403.05508107
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.92123098
4Vitamin B6 metabolism_Homo sapiens_hsa007502.87366060
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.72838600
6Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.70243222
7Proteasome_Homo sapiens_hsa030502.69696013
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.66927741
9Caffeine metabolism_Homo sapiens_hsa002322.54120098
10Regulation of autophagy_Homo sapiens_hsa041402.53198109
11T cell receptor signaling pathway_Homo sapiens_hsa046602.37548434
12Collecting duct acid secretion_Homo sapiens_hsa049662.36960968
13Histidine metabolism_Homo sapiens_hsa003402.33035265
14Tryptophan metabolism_Homo sapiens_hsa003802.21014707
15RNA polymerase_Homo sapiens_hsa030202.18633687
16Viral myocarditis_Homo sapiens_hsa054162.10452883
17beta-Alanine metabolism_Homo sapiens_hsa004102.10436859
18Olfactory transduction_Homo sapiens_hsa047402.08949579
19Cardiac muscle contraction_Homo sapiens_hsa042602.07892888
20Pentose and glucuronate interconversions_Homo sapiens_hsa000402.06829216
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.04512166
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.01529418
23Propanoate metabolism_Homo sapiens_hsa006401.98832770
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.81657785
25Alzheimers disease_Homo sapiens_hsa050101.81615222
26Synaptic vesicle cycle_Homo sapiens_hsa047211.79159045
27Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.78617395
28Protein export_Homo sapiens_hsa030601.78519963
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.70737025
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.70199033
31SNARE interactions in vesicular transport_Homo sapiens_hsa041301.65901537
32Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.65543784
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.58788589
34Circadian rhythm_Homo sapiens_hsa047101.56990871
35Mismatch repair_Homo sapiens_hsa034301.54929408
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.51192423
37FoxO signaling pathway_Homo sapiens_hsa040681.49020330
38Nicotine addiction_Homo sapiens_hsa050331.48043237
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.45197780
40Asthma_Homo sapiens_hsa053101.40531748
41Hematopoietic cell lineage_Homo sapiens_hsa046401.35425302
42Morphine addiction_Homo sapiens_hsa050321.32991409
43Huntingtons disease_Homo sapiens_hsa050161.31038496
44Vibrio cholerae infection_Homo sapiens_hsa051101.29050396
45Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.28241510
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.27910981
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.27418067
48Homologous recombination_Homo sapiens_hsa034401.25741189
49Non-homologous end-joining_Homo sapiens_hsa034501.22534696
50Type II diabetes mellitus_Homo sapiens_hsa049301.21504166
51Long-term potentiation_Homo sapiens_hsa047201.21127498
52Taste transduction_Homo sapiens_hsa047421.21020975
53Endometrial cancer_Homo sapiens_hsa052131.19364991
54Graft-versus-host disease_Homo sapiens_hsa053321.18839514
55Peroxisome_Homo sapiens_hsa041461.18561584
56ABC transporters_Homo sapiens_hsa020101.17960269
57RNA degradation_Homo sapiens_hsa030181.15654193
58Phototransduction_Homo sapiens_hsa047441.14487237
59Measles_Homo sapiens_hsa051621.14400498
60Fatty acid degradation_Homo sapiens_hsa000711.14234033
61Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.10950911
62Folate biosynthesis_Homo sapiens_hsa007901.10259126
63Legionellosis_Homo sapiens_hsa051341.10070263
64Renal cell carcinoma_Homo sapiens_hsa052111.09751254
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.08216811
66Cell cycle_Homo sapiens_hsa041101.08111803
67Phagosome_Homo sapiens_hsa041451.07123167
68Phosphatidylinositol signaling system_Homo sapiens_hsa040701.07039293
69Lysine degradation_Homo sapiens_hsa003101.06067599
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.03563344
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.03004673
72Alcoholism_Homo sapiens_hsa050341.01754018
73Glycerolipid metabolism_Homo sapiens_hsa005611.01171526
74NF-kappa B signaling pathway_Homo sapiens_hsa040641.00982356
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.00670202
76Pyrimidine metabolism_Homo sapiens_hsa002400.99121621
77Serotonergic synapse_Homo sapiens_hsa047260.96710365
78GABAergic synapse_Homo sapiens_hsa047270.94679383
79One carbon pool by folate_Homo sapiens_hsa006700.92273987
80Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.91970769
81Epstein-Barr virus infection_Homo sapiens_hsa051690.91619096
82Systemic lupus erythematosus_Homo sapiens_hsa053220.91267601
83mTOR signaling pathway_Homo sapiens_hsa041500.91085156
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.91054036
85Rheumatoid arthritis_Homo sapiens_hsa053230.90314384
86Nucleotide excision repair_Homo sapiens_hsa034200.90125924
87Pentose phosphate pathway_Homo sapiens_hsa000300.89891131
88Dopaminergic synapse_Homo sapiens_hsa047280.89664276
89Basal transcription factors_Homo sapiens_hsa030220.89331676
90Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.88500040
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.86440640
92Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.85636828
93B cell receptor signaling pathway_Homo sapiens_hsa046620.84974825
94Inositol phosphate metabolism_Homo sapiens_hsa005620.84002932
95Dorso-ventral axis formation_Homo sapiens_hsa043200.83343185
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.82557214
97Autoimmune thyroid disease_Homo sapiens_hsa053200.81062069
98Pancreatic cancer_Homo sapiens_hsa052120.80941540
99Cholinergic synapse_Homo sapiens_hsa047250.80450567
100Non-small cell lung cancer_Homo sapiens_hsa052230.78977725
101Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77065184
102Oocyte meiosis_Homo sapiens_hsa041140.76899299
103Insulin signaling pathway_Homo sapiens_hsa049100.76242595
104RNA transport_Homo sapiens_hsa030130.75474235
105Insulin secretion_Homo sapiens_hsa049110.75301836
106Antigen processing and presentation_Homo sapiens_hsa046120.74299044
107Steroid hormone biosynthesis_Homo sapiens_hsa001400.73766179
108Chemokine signaling pathway_Homo sapiens_hsa040620.72510166
109Butanoate metabolism_Homo sapiens_hsa006500.72206224
110Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.70268763
111Ribosome_Homo sapiens_hsa030100.69696553
112Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.69655679
113p53 signaling pathway_Homo sapiens_hsa041150.69093356
114Allograft rejection_Homo sapiens_hsa053300.68741181
115Glioma_Homo sapiens_hsa052140.66892806
116Chronic myeloid leukemia_Homo sapiens_hsa052200.65978082
117Oxytocin signaling pathway_Homo sapiens_hsa049210.65040884
118Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64353867
119Prostate cancer_Homo sapiens_hsa052150.63834914
120Arginine and proline metabolism_Homo sapiens_hsa003300.62853658
121Parkinsons disease_Homo sapiens_hsa050120.62269005
122* Spliceosome_Homo sapiens_hsa030400.61875747
123Type I diabetes mellitus_Homo sapiens_hsa049400.60964880
124Long-term depression_Homo sapiens_hsa047300.60452752
125Selenocompound metabolism_Homo sapiens_hsa004500.58948364
126Pancreatic secretion_Homo sapiens_hsa049720.57273923
127Herpes simplex infection_Homo sapiens_hsa051680.57166029
128Viral carcinogenesis_Homo sapiens_hsa052030.55202984
129Dilated cardiomyopathy_Homo sapiens_hsa054140.54482117
130RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.53787291
131Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53525544
132Glucagon signaling pathway_Homo sapiens_hsa049220.53428313
133Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52471254
134Apoptosis_Homo sapiens_hsa042100.52373825
135Pertussis_Homo sapiens_hsa051330.52136906
136Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51649413
137Estrogen signaling pathway_Homo sapiens_hsa049150.51078087
138Oxidative phosphorylation_Homo sapiens_hsa001900.50802438
139Osteoclast differentiation_Homo sapiens_hsa043800.50682517
140Hepatitis B_Homo sapiens_hsa051610.49831109
141Colorectal cancer_Homo sapiens_hsa052100.49209441
142Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49005538
143Prolactin signaling pathway_Homo sapiens_hsa049170.48066889
144Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47895077
145Purine metabolism_Homo sapiens_hsa002300.47781508
146Glutamatergic synapse_Homo sapiens_hsa047240.47223469
147Retinol metabolism_Homo sapiens_hsa008300.46919243
148Renin secretion_Homo sapiens_hsa049240.46193285
149Fanconi anemia pathway_Homo sapiens_hsa034600.45891567
150Phenylalanine metabolism_Homo sapiens_hsa003600.45134829
151DNA replication_Homo sapiens_hsa030300.44743420
152Endocytosis_Homo sapiens_hsa041440.44584990
153AMPK signaling pathway_Homo sapiens_hsa041520.44243553
154NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43106080
155Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42765800
156Drug metabolism - other enzymes_Homo sapiens_hsa009830.39704969
157Steroid biosynthesis_Homo sapiens_hsa001000.39372242
158Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.38180320
159Metabolic pathways_Homo sapiens_hsa011000.36429782
160Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32707217
161Chemical carcinogenesis_Homo sapiens_hsa052040.30993582
162Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.28155722
163TGF-beta signaling pathway_Homo sapiens_hsa043500.26823568
164Transcriptional misregulation in cancer_Homo sapiens_hsa052020.23282788
165Proteoglycans in cancer_Homo sapiens_hsa052050.22097111

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »