PRPF19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: PSO4 is the human homolog of yeast Pso4, a gene essential for cell survival and DNA repair (Beck et al., 2008 [PubMed 18263876]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic chromosome condensation (GO:0007076)4.93366229
2Golgi transport vesicle coating (GO:0048200)4.73043542
3COPI coating of Golgi vesicle (GO:0048205)4.73043542
4proline biosynthetic process (GO:0006561)4.56950685
5plasma membrane repair (GO:0001778)4.46683064
6negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.37379731
7nuclear pore complex assembly (GO:0051292)4.31979164
8ribosomal small subunit biogenesis (GO:0042274)4.22761457
9regulation of mammary gland epithelial cell proliferation (GO:0033599)4.17025538
10negative regulation of potassium ion transmembrane transport (GO:1901380)4.16667987
11cardiac myofibril assembly (GO:0055003)3.78216399
12negative regulation of cell size (GO:0045792)3.77599531
13peptidyl-lysine dimethylation (GO:0018027)3.72482503
14pre-miRNA processing (GO:0031054)3.69957375
15regulation of translational fidelity (GO:0006450)3.65642514
16cytoskeletal anchoring at plasma membrane (GO:0007016)3.64578582
17formation of translation preinitiation complex (GO:0001731)3.62132057
18activation of Rac GTPase activity (GO:0032863)3.58113032
19nuclear pore organization (GO:0006999)3.56222104
20positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.52707668
21retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.52151329
22maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.49085839
23maternal placenta development (GO:0001893)3.47481096
24regulation of early endosome to late endosome transport (GO:2000641)3.47230965
25protein retention in ER lumen (GO:0006621)3.45653504
26layer formation in cerebral cortex (GO:0021819)3.43951705
27sarcomere organization (GO:0045214)3.40614720
28protein complex localization (GO:0031503)3.40545439
29regulation of RNA export from nucleus (GO:0046831)3.38196241
30cellular protein complex localization (GO:0034629)3.33712157
31adherens junction assembly (GO:0034333)3.30920148
323-UTR-mediated mRNA stabilization (GO:0070935)3.30219317
33regulation of nucleobase-containing compound transport (GO:0032239)3.29302177
34DNA strand elongation involved in DNA replication (GO:0006271)3.26501227
35DNA replication initiation (GO:0006270)3.24874731
36protein export from nucleus (GO:0006611)3.23737959
37DNA strand elongation (GO:0022616)3.23135161
38mitotic sister chromatid segregation (GO:0000070)3.22379451
39pentose-phosphate shunt (GO:0006098)3.19674674
40polarized epithelial cell differentiation (GO:0030859)3.19319413
41negative regulation of erythrocyte differentiation (GO:0045647)3.18506296
42regulation of translational termination (GO:0006449)3.15656651
43regulation of histone H3-K27 methylation (GO:0061085)3.15410741
44nucleosome disassembly (GO:0006337)3.13930522
45protein-DNA complex disassembly (GO:0032986)3.13930522
46peptidyl-arginine omega-N-methylation (GO:0035247)3.11580319
47regulation of hippo signaling (GO:0035330)3.08365538
48pore complex assembly (GO:0046931)3.07999970
49focal adhesion assembly (GO:0048041)3.07347482
50cell-substrate adherens junction assembly (GO:0007045)3.07347482
51regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 3.06339700
52positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling3.06339700
53regulation of NFAT protein import into nucleus (GO:0051532)3.03308785
54cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.02949441
55chromosome condensation (GO:0030261)3.01338541
56positive regulation of RNA splicing (GO:0033120)3.01023256
57establishment of apical/basal cell polarity (GO:0035089)3.00052365
58histone arginine methylation (GO:0034969)3.00050045
59maturation of SSU-rRNA (GO:0030490)2.98875141
60planar cell polarity pathway involved in neural tube closure (GO:0090179)2.95328221
61proline metabolic process (GO:0006560)2.94831950
62regulation of glucose import in response to insulin stimulus (GO:2001273)2.94569797
63negative regulation of nucleotide catabolic process (GO:0030812)2.94324462
64sister chromatid segregation (GO:0000819)2.94322671
65myofibril assembly (GO:0030239)2.94299902
66paraxial mesoderm development (GO:0048339)2.93914452
67glucocorticoid receptor signaling pathway (GO:0042921)2.93341234
68heterochromatin organization (GO:0070828)2.93050033
69cardiac muscle contraction (GO:0060048)2.93008358
70viral transcription (GO:0019083)2.92653632
71nucleobase-containing small molecule interconversion (GO:0015949)2.92606401
72regulation of chromatin binding (GO:0035561)2.87347139
73cell communication by electrical coupling (GO:0010644)2.86871227
74protein localization to endosome (GO:0036010)2.85597852
75G1 DNA damage checkpoint (GO:0044783)2.84925778
76protein localization to chromosome, centromeric region (GO:0071459)2.84550755
77* spliceosomal tri-snRNP complex assembly (GO:0000244)2.83586300
78nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.82755162
79regulation of fatty acid beta-oxidation (GO:0031998)2.81055989
80regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.78892791
81negative regulation of mRNA processing (GO:0050686)2.78812122
82peptidyl-arginine N-methylation (GO:0035246)2.78523611
83peptidyl-arginine methylation (GO:0018216)2.78523611
84regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.78494042
85regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.78435228
86cellular response to epidermal growth factor stimulus (GO:0071364)2.78293499
87protein maturation by protein folding (GO:0022417)2.78285494
88cell migration in hindbrain (GO:0021535)2.77213568
89DNA unwinding involved in DNA replication (GO:0006268)2.76449747
90positive regulation of nuclease activity (GO:0032075)2.76241135
91activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.74900088
92NLS-bearing protein import into nucleus (GO:0006607)2.74708846
93negative regulation of cardiac muscle tissue growth (GO:0055022)2.73942391
94negative regulation of heart growth (GO:0061117)2.73942391
95glucose catabolic process (GO:0006007)2.73497352
96mitotic nuclear envelope disassembly (GO:0007077)2.73339430
97DNA duplex unwinding (GO:0032508)2.71514333
98DNA topological change (GO:0006265)2.71313401
99establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.70225340
100NADPH regeneration (GO:0006740)2.69290305
101negative regulation of mRNA metabolic process (GO:1903312)2.69227575
102negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.69215920
103dicarboxylic acid biosynthetic process (GO:0043650)2.68550378
104cell communication involved in cardiac conduction (GO:0086065)2.67101622
105translational termination (GO:0006415)2.66984321
106ribonucleoprotein complex biogenesis (GO:0022613)2.66856467
107negative regulation of RNA splicing (GO:0033119)2.66598712
108nuclear envelope disassembly (GO:0051081)2.66180183
109membrane disassembly (GO:0030397)2.66180183
110positive regulation of histone deacetylation (GO:0031065)2.64807346
111glucose 6-phosphate metabolic process (GO:0051156)2.64613687
112hippo signaling (GO:0035329)2.63896995
113epithelial cell differentiation involved in prostate gland development (GO:0060742)2.63869740
114regulation of gene silencing by RNA (GO:0060966)2.61300640
115regulation of posttranscriptional gene silencing (GO:0060147)2.61300640
116regulation of gene silencing by miRNA (GO:0060964)2.61300640
117insulin-like growth factor receptor signaling pathway (GO:0048009)2.61189150
118folic acid metabolic process (GO:0046655)2.60079455
119cardiac muscle cell development (GO:0055013)2.59986833
120RNA stabilization (GO:0043489)2.59789045
121mRNA stabilization (GO:0048255)2.59789045
122mitotic nuclear envelope reassembly (GO:0007084)2.59493381
123nuclear envelope reassembly (GO:0031468)2.59493381
124folic acid-containing compound biosynthetic process (GO:0009396)2.59068413
125mitotic G1/S transition checkpoint (GO:0044819)2.58576416
126aspartate family amino acid catabolic process (GO:0009068)2.57743751
127regulation of mitotic spindle organization (GO:0060236)2.57294557
128negative regulation of purine nucleotide catabolic process (GO:0033122)2.56800887
129carnitine shuttle (GO:0006853)2.56612532
130establishment of nucleus localization (GO:0040023)2.55364823
131telomere maintenance via semi-conservative replication (GO:0032201)2.55252919
132rRNA transcription (GO:0009303)2.55232487
133cytoplasmic mRNA processing body assembly (GO:0033962)2.54860678
134positive regulation of DNA-dependent DNA replication (GO:2000105)2.54831915
135mitotic sister chromatid cohesion (GO:0007064)2.53654108
136establishment of monopolar cell polarity (GO:0061162)2.51671365
137establishment or maintenance of monopolar cell polarity (GO:0061339)2.51671365
138glial cell proliferation (GO:0014009)2.50887911
139negative regulation of catenin import into nucleus (GO:0035414)2.49941815
140actin-myosin filament sliding (GO:0033275)2.49842552
141muscle filament sliding (GO:0030049)2.49842552
142apoptotic process involved in morphogenesis (GO:0060561)2.49283108
143sodium ion export (GO:0071436)2.48598761
144negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.46816364
145cerebellar Purkinje cell layer development (GO:0021680)2.46604890
146positive regulation of fatty acid beta-oxidation (GO:0032000)2.46089154
147negative regulation of organelle assembly (GO:1902116)2.45836790
148actomyosin structure organization (GO:0031032)2.44185573
149positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.44144124
150heart trabecula formation (GO:0060347)2.42359679
151cardiac cell development (GO:0055006)2.41943225
152lysine metabolic process (GO:0006553)2.41060278
153lysine catabolic process (GO:0006554)2.41060278
154positive regulation of glycogen biosynthetic process (GO:0045725)2.39823414
155cell-substrate junction assembly (GO:0007044)2.38963517
156ventricular cardiac muscle cell action potential (GO:0086005)2.36695548
1572-oxoglutarate metabolic process (GO:0006103)2.34556000
158negative regulation of GTPase activity (GO:0034260)2.30864375
159negative regulation of GTP catabolic process (GO:0033125)2.30864375
160mitotic G1 DNA damage checkpoint (GO:0031571)2.30104962
161intracellular estrogen receptor signaling pathway (GO:0030520)2.30011291
162embryonic foregut morphogenesis (GO:0048617)2.28857999
163negative regulation of microtubule polymerization (GO:0031115)2.23613421
164chromatin assembly (GO:0031497)2.23517338
165stress fiber assembly (GO:0043149)2.23358539
166fatty acid transmembrane transport (GO:1902001)2.22791630
167regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.20230257
168positive regulation of SMAD protein import into nucleus (GO:0060391)2.20147683
169locomotory exploration behavior (GO:0035641)2.19718855
170cardiac muscle cell proliferation (GO:0060038)2.19230150
171neuromuscular junction development (GO:0007528)2.19180292
172gastrulation with mouth forming second (GO:0001702)2.19098509
173adult heart development (GO:0007512)2.18978305
174creatine metabolic process (GO:0006600)2.18328804
175regulation of fatty acid oxidation (GO:0046320)2.17420691
176negative regulation of potassium ion transport (GO:0043267)2.15275415
177striated muscle contraction (GO:0006941)2.15211869

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human3.06727379
2STAT6_21828071_ChIP-Seq_BEAS2B_Human2.94890872
3ZFP281_18757296_ChIP-ChIP_E14_Mouse2.86502420
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.80937411
5ZNF263_19887448_ChIP-Seq_K562_Human2.78514951
6EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.62715728
7* MYC_18555785_ChIP-Seq_MESCs_Mouse2.59539513
8* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.54021140
9MYC_22102868_ChIP-Seq_BL_Human2.51469522
10ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.47729937
11* KDM2B_26808549_Chip-Seq_DND41_Human2.37126828
12KDM2B_26808549_Chip-Seq_SUP-B15_Human2.28116302
13ZFP281_27345836_Chip-Seq_ESCs_Mouse2.25429613
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.13360155
15WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.11539485
16ESR1_15608294_ChIP-ChIP_MCF-7_Human2.11070393
17LXR_22292898_ChIP-Seq_THP-1_Human2.09021523
18SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.02577032
19CLOCK_20551151_ChIP-Seq_293T_Human1.98342387
20KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.97657826
21TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92436389
22TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.92435215
23KDM2B_26808549_Chip-Seq_K562_Human1.91862929
24ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.91559446
25KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.85191823
26EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.85117483
27* XRN2_22483619_ChIP-Seq_HELA_Human1.84904074
28P300_27058665_Chip-Seq_ZR-75-30cells_Human1.83187933
29KDM2B_26808549_Chip-Seq_JURKAT_Human1.82379326
30* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.81931101
31* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.81200223
32TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.78307172
33E2F7_22180533_ChIP-Seq_HELA_Human1.77159856
34DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.76340433
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.76060371
36CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.75119622
37ELK3_25401928_ChIP-Seq_HUVEC_Human1.74483948
38NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.72747915
39RACK7_27058665_Chip-Seq_MCF-7_Human1.71620858
40EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.70583309
41TCF7_22412390_ChIP-Seq_EML_Mouse1.70326417
42FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.69686998
43* CREB1_26743006_Chip-Seq_LNCaP_Human1.68322660
44* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.67183300
45FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.65155984
46* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.64923251
47ERG_21242973_ChIP-ChIP_JURKAT_Human1.64273307
48* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.61694349
49EGR1_19374776_ChIP-ChIP_THP-1_Human1.60806023
50VDR_21846776_ChIP-Seq_THP-1_Human1.58561507
51CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.58003394
52SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.55781330
53KLF4_18555785_ChIP-Seq_MESCs_Mouse1.55115204
54SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.54019599
55RARB_27405468_Chip-Seq_BRAIN_Mouse1.53298927
56ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.51288602
57ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.50146648
58TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.48799751
59* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.48391943
60* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.43865472
61TET1_21451524_ChIP-Seq_MESCs_Mouse1.43672803
62AR_21909140_ChIP-Seq_LNCAP_Human1.43397298
63EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.42812330
64SRY_22984422_ChIP-ChIP_TESTIS_Rat1.41946952
65RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.41422026
66NELFA_20434984_ChIP-Seq_ESCs_Mouse1.39033808
67POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.38134951
68ATF3_27146783_Chip-Seq_COLON_Human1.36628577
69DNAJC2_21179169_ChIP-ChIP_NT2_Human1.36344599
70RARG_19884340_ChIP-ChIP_MEFs_Mouse1.35309122
71ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.31571610
72MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.31345469
73NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.30913317
74MYC_19079543_ChIP-ChIP_MESCs_Mouse1.30097691
75UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.29316818
76KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.28266818
77TBX20_22328084_ChIP-Seq_HEART_Mouse1.26305615
78TBX20_22080862_ChIP-Seq_HEART_Mouse1.26305615
79ESR2_21235772_ChIP-Seq_MCF-7_Human1.25979440
80MYCN_18555785_ChIP-Seq_MESCs_Mouse1.25671209
81POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.24949738
82* P68_20966046_ChIP-Seq_HELA_Human1.24824584
83TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.23876505
84PPARA_22158963_ChIP-Seq_LIVER_Mouse1.23498262
85TP53_22127205_ChIP-Seq_IMR90_Human1.23191678
86HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.21408068
87NANOG_18555785_ChIP-Seq_MESCs_Mouse1.21050827
88POU5F1_16518401_ChIP-PET_MESCs_Mouse1.20752457
89MAF_26560356_Chip-Seq_TH1_Human1.15917819
90CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.15386404
91E2F1_21310950_ChIP-Seq_MCF-7_Human1.14899148
92* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.14832495
93ISL1_27105846_Chip-Seq_CPCs_Mouse1.14538456
94ESR1_20079471_ChIP-ChIP_T-47D_Human1.13504480
95ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.13163035
96NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.13159385
97SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.12726348
98* NCOR1_26117541_ChIP-Seq_K562_Human1.12709330
99STAT3_1855785_ChIP-Seq_MESCs_Mouse1.12137816
100HIF1A_21447827_ChIP-Seq_MCF-7_Human1.11802199
101DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.11666616
102DCP1A_22483619_ChIP-Seq_HELA_Human1.11046589
103CTCF_27219007_Chip-Seq_Bcells_Human1.10564977
104SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.10465595
105* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.09649548
106EZH2_22144423_ChIP-Seq_EOC_Human1.09183930
107TP53_20018659_ChIP-ChIP_R1E_Mouse1.08785171
108NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.08719130
109KDM5A_27292631_Chip-Seq_BREAST_Human1.08711278
110RUNX1_27514584_Chip-Seq_MCF-7_Human1.08614653
111KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.08371413
112KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.08371413
113KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.08371413
114MAF_26560356_Chip-Seq_TH2_Human1.07784810
115DROSHA_22980978_ChIP-Seq_HELA_Human1.07738846
116CIITA_25753668_ChIP-Seq_RAJI_Human1.05537376
117VDR_24763502_ChIP-Seq_THP-1_Human1.05051095
118CHD1_26751641_Chip-Seq_LNCaP_Human1.04838987
119RXR_22158963_ChIP-Seq_LIVER_Mouse1.04647452
120TP63_17297297_ChIP-ChIP_HaCaT_Human1.03024229
121NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.02754600
122TCF3_18692474_ChIP-Seq_MEFs_Mouse1.02434077
123TTF2_22483619_ChIP-Seq_HELA_Human1.02240338
124NANOG_21062744_ChIP-ChIP_HESCs_Human1.01731972
125KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.01686193
126GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01514282
127MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.01175337
128FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.01070492
129E2F4_17652178_ChIP-ChIP_JURKAT_Human1.01060944
130TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01054072
131SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.00905829
132RING1B_27294783_Chip-Seq_NPCs_Mouse1.00882077
133TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00797048
134CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00431070
135SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.99867848
136ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99726116
137* SA1_27219007_Chip-Seq_ERYTHROID_Human0.99492824
138CTCF_27219007_Chip-Seq_ERYTHROID_Human0.99086696
139GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98597042
140UTX_26944678_Chip-Seq_JUKART_Human0.98430531
141TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97646478
142SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97371305
143NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97266300
144* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.96851621
145SMC4_20622854_ChIP-Seq_HELA_Human0.96327540
146JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.96231389

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.82272295
2MP0002877_abnormal_melanocyte_morpholog3.39739445
3MP0000751_myopathy3.35851149
4MP0003111_abnormal_nucleus_morphology3.03837722
5MP0005451_abnormal_body_composition3.02305397
6MP0002837_dystrophic_cardiac_calcinosis2.92230086
7MP0003693_abnormal_embryo_hatching2.77154382
8MP0005623_abnormal_meninges_morphology2.57876807
9MP0004084_abnormal_cardiac_muscle2.50470930
10MP0004957_abnormal_blastocyst_morpholog2.50036338
11MP0004233_abnormal_muscle_weight2.46377786
12MP0000537_abnormal_urethra_morphology2.43717172
13MP0004087_abnormal_muscle_fiber2.23705554
14MP0010094_abnormal_chromosome_stability2.23429883
15MP0003077_abnormal_cell_cycle2.20170062
16MP0002796_impaired_skin_barrier2.09493291
17MP0004185_abnormal_adipocyte_glucose2.08506872
18MP0000747_muscle_weakness1.99186577
19MP0000733_abnormal_muscle_development1.96584417
20MP0000750_abnormal_muscle_regeneration1.94795848
21MP0003283_abnormal_digestive_organ1.94169679
22MP0000678_abnormal_parathyroid_gland1.90032111
23MP0005076_abnormal_cell_differentiation1.90030581
24MP0005330_cardiomyopathy1.87247471
25MP0004145_abnormal_muscle_electrophysio1.85958764
26* MP0000350_abnormal_cell_proliferation1.85613530
27MP0009053_abnormal_anal_canal1.81500413
28MP0004130_abnormal_muscle_cell1.78606990
29MP0004859_abnormal_synaptic_plasticity1.78546169
30MP0005058_abnormal_lysosome_morphology1.77442188
31MP0005501_abnormal_skin_physiology1.77299607
32MP0002269_muscular_atrophy1.74125723
33MP0003123_paternal_imprinting1.72895828
34MP0004036_abnormal_muscle_relaxation1.72471573
35MP0003453_abnormal_keratinocyte_physiol1.71906506
36MP0010630_abnormal_cardiac_muscle1.71851726
37MP0008932_abnormal_embryonic_tissue1.71349693
38MP0010234_abnormal_vibrissa_follicle1.69002602
39MP0000759_abnormal_skeletal_muscle1.68067336
40MP0010030_abnormal_orbit_morphology1.67598965
41MP0005187_abnormal_penis_morphology1.66302725
42MP0004215_abnormal_myocardial_fiber1.64770943
43MP0002396_abnormal_hematopoietic_system1.61576931
44MP0003137_abnormal_impulse_conducting1.58699518
45MP0008260_abnormal_autophagy1.55074939
46MP0008961_abnormal_basal_metabolism1.54936436
47MP0004197_abnormal_fetal_growth/weight/1.54117178
48MP0000428_abnormal_craniofacial_morphol1.53120685
49MP0010352_gastrointestinal_tract_polyps1.52348330
50MP0002106_abnormal_muscle_physiology1.52267363
51MP0003646_muscle_fatigue1.51984860
52MP0005409_darkened_coat_color1.50759307
53MP0004264_abnormal_extraembryonic_tissu1.48285175
54MP0000749_muscle_degeneration1.47200017
55MP0001346_abnormal_lacrimal_gland1.46054520
56MP0003119_abnormal_digestive_system1.45299746
57MP0005666_abnormal_adipose_tissue1.44812015
58MP0001849_ear_inflammation1.43077466
59MP0003385_abnormal_body_wall1.41759805
60MP0002089_abnormal_postnatal_growth/wei1.40588495
61MP0002084_abnormal_developmental_patter1.36401829
62MP0009780_abnormal_chondrocyte_physiolo1.35561596
63MP0004808_abnormal_hematopoietic_stem1.34867623
64MP0008057_abnormal_DNA_replication1.33427728
65MP0003567_abnormal_fetal_cardiomyocyte1.31898848
66MP0001730_embryonic_growth_arrest1.30213047
67MP0002234_abnormal_pharynx_morphology1.29096584
68MP0005369_muscle_phenotype1.29043410
69MP0008007_abnormal_cellular_replicative1.26895943
70MP0000490_abnormal_crypts_of1.26789130
71MP0005375_adipose_tissue_phenotype1.23329991
72MP0005621_abnormal_cell_physiology1.21760647
73MP0004858_abnormal_nervous_system1.20224231
74MP0009672_abnormal_birth_weight1.19403793
75MP0000313_abnormal_cell_death1.19109668
76MP0002085_abnormal_embryonic_tissue1.18421769
77MP0003221_abnormal_cardiomyocyte_apopto1.17098272
78MP0009333_abnormal_splenocyte_physiolog1.16743142
79MP0003115_abnormal_respiratory_system1.15213638
80MP0009278_abnormal_bone_marrow1.15198470
81MP0003122_maternal_imprinting1.14394604
82MP0006138_congestive_heart_failure1.14085226
83MP0000534_abnormal_ureter_morphology1.13723595
84MP0000858_altered_metastatic_potential1.13230546
85MP0005620_abnormal_muscle_contractility1.12641429
86MP0003763_abnormal_thymus_physiology1.12592774
87MP0000566_synostosis1.11855940
88MP0002653_abnormal_ependyma_morphology1.10512333
89MP0005385_cardiovascular_system_phenoty1.08489522
90MP0001544_abnormal_cardiovascular_syste1.08489522
91MP0002972_abnormal_cardiac_muscle1.08408597
92MP0002088_abnormal_embryonic_growth/wei1.08374589
93MP0003091_abnormal_cell_migration1.08202879
94MP0000003_abnormal_adipose_tissue1.07522302
95MP0003984_embryonic_growth_retardation1.07001780
96MP0004085_abnormal_heartbeat1.06671677
97MP0002009_preneoplasia1.06665751
98MP0005083_abnormal_biliary_tract1.06639949
99MP0003566_abnormal_cell_adhesion1.05862313
100MP0004272_abnormal_basement_membrane1.05271856
101* MP0001672_abnormal_embryogenesis/_devel1.05079656
102* MP0005380_embryogenesis_phenotype1.05079656
103MP0001661_extended_life_span1.02973191
104MP0004947_skin_inflammation1.02258823
105MP0003861_abnormal_nervous_system1.01655642
106MP0001697_abnormal_embryo_size1.01333962
107MP0002060_abnormal_skin_morphology1.00945114
108MP0002909_abnormal_adrenal_gland1.00880845
109MP0000266_abnormal_heart_morphology1.00867945
110MP0008775_abnormal_heart_ventricle1.00141150
111MP0003935_abnormal_craniofacial_develop0.99324834
112MP0009379_abnormal_foot_pigmentation0.99234253
113MP0010307_abnormal_tumor_latency0.99083082
114MP0001348_abnormal_lacrimal_gland0.99049250
115MP0005257_abnormal_intraocular_pressure0.97522043
116MP0002086_abnormal_extraembryonic_tissu0.97421307
117MP0009703_decreased_birth_body0.96412300
118MP0001216_abnormal_epidermal_layer0.95662506
119MP0003942_abnormal_urinary_system0.94905428
120MP0003315_abnormal_perineum_morphology0.94423151
121MP0001299_abnormal_eye_distance/0.93198695
122MP0000703_abnormal_thymus_morphology0.92208472
123MP0005384_cellular_phenotype0.92087896
124MP0002697_abnormal_eye_size0.91830972
125MP0002108_abnormal_muscle_morphology0.91684704
126MP0003300_gastrointestinal_ulcer0.90594094
127MP0008770_decreased_survivor_rate0.89377672
128MP0009931_abnormal_skin_appearance0.88663761
129MP0002098_abnormal_vibrissa_morphology0.88280589
130* MP0002080_prenatal_lethality0.87323129
131MP0009840_abnormal_foam_cell0.87086434
132MP0002925_abnormal_cardiovascular_devel0.85980709
133MP0000579_abnormal_nail_morphology0.85436207
134MP0004885_abnormal_endolymph0.85170514
135MP0003937_abnormal_limbs/digits/tail_de0.82623227
136MP0002932_abnormal_joint_morphology0.82571500
137MP0000467_abnormal_esophagus_morphology0.82211290
138MP0002249_abnormal_larynx_morphology0.82192095
139MP0002111_abnormal_tail_morphology0.78143094
140MP0000377_abnormal_hair_follicle0.76069115
141MP0004782_abnormal_surfactant_physiolog0.75851946
142MP0003329_amyloid_beta_deposits0.75834490
143MP0003121_genomic_imprinting0.75438870
144MP0008438_abnormal_cutaneous_collagen0.75425474
145MP0004484_altered_response_of0.75334129
146MP0002152_abnormal_brain_morphology0.74902504
147MP0000681_abnormal_thyroid_gland0.73705581
148MP0000778_abnormal_nervous_system0.73602978
149MP0001915_intracranial_hemorrhage0.73546517
150MP0000762_abnormal_tongue_morphology0.73473105
151MP0002127_abnormal_cardiovascular_syste0.73020561
152MP0000627_abnormal_mammary_gland0.72862228
153MP0001881_abnormal_mammary_gland0.72819771
154MP0002019_abnormal_tumor_incidence0.72658762
155MP0003635_abnormal_synaptic_transmissio0.71951892
156MP0000477_abnormal_intestine_morphology0.70349221

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)3.65205688
2Exercise-induced muscle cramps (HP:0003710)3.38597993
3Hyporeflexia of lower limbs (HP:0002600)3.35135980
4Hyperacusis (HP:0010780)3.16789370
5Achilles tendon contracture (HP:0001771)3.13600946
6Exercise-induced myalgia (HP:0003738)3.04866105
7Abnormality of the Achilles tendon (HP:0005109)3.01670556
8Difficulty running (HP:0009046)3.00678411
9Pseudobulbar signs (HP:0002200)2.80225979
10Abnormality of the lower motor neuron (HP:0002366)2.78581794
11Increased connective tissue (HP:0009025)2.74513506
12Insomnia (HP:0100785)2.71195717
13Ependymoma (HP:0002888)2.67744961
14Progressive muscle weakness (HP:0003323)2.67215445
15Shallow orbits (HP:0000586)2.66390436
16Asymmetry of the thorax (HP:0001555)2.62310378
17Renal duplication (HP:0000075)2.61693277
18Termporal pattern (HP:0011008)2.60891335
19Insidious onset (HP:0003587)2.60891335
20Long palpebral fissure (HP:0000637)2.60566361
21Difficulty climbing stairs (HP:0003551)2.58768218
22Lymphangioma (HP:0100764)2.58283138
23Muscle fiber splitting (HP:0003555)2.54718411
24Myoglobinuria (HP:0002913)2.54497740
25Astrocytoma (HP:0009592)2.44946034
26Abnormality of the astrocytes (HP:0100707)2.44946034
27Ventricular tachycardia (HP:0004756)2.44465608
28Cerebral aneurysm (HP:0004944)2.43180814
29Bundle branch block (HP:0011710)2.41789579
30Trismus (HP:0000211)2.41460519
31Calf muscle hypertrophy (HP:0008981)2.41453816
32Elfin facies (HP:0004428)2.41260911
33Increased variability in muscle fiber diameter (HP:0003557)2.40397655
34Dysmetric saccades (HP:0000641)2.40284861
35Vertebral compression fractures (HP:0002953)2.37496982
36Abnormal gallbladder physiology (HP:0012438)2.37326737
37Cholecystitis (HP:0001082)2.37326737
38Muscle hypertrophy of the lower extremities (HP:0008968)2.36358984
39Type 1 muscle fiber predominance (HP:0003803)2.34302996
40Broad face (HP:0000283)2.33541614
41Scapular winging (HP:0003691)2.32369810
42Overriding aorta (HP:0002623)2.31402227
43Renovascular hypertension (HP:0100817)2.27363466
44Abnormality of the calf musculature (HP:0001430)2.26367213
45Flat acetabular roof (HP:0003180)2.25820332
46Abnormality of the 4th metacarpal (HP:0010012)2.25585406
47Centrally nucleated skeletal muscle fibers (HP:0003687)2.25176360
48Fibroma (HP:0010614)2.23552271
49Pointed chin (HP:0000307)2.22818656
50Broad distal phalanx of finger (HP:0009836)2.22508543
51Selective tooth agenesis (HP:0001592)2.22414320
52Angiofibromas (HP:0010615)2.22395422
53Adenoma sebaceum (HP:0009720)2.22395422
54EMG: myopathic abnormalities (HP:0003458)2.22274085
55Obstructive sleep apnea (HP:0002870)2.21477101
56Disproportionate tall stature (HP:0001519)2.21107407
57Back pain (HP:0003418)2.20710771
58Right ventricular cardiomyopathy (HP:0011663)2.20433028
59Upper limb amyotrophy (HP:0009129)2.20383111
60Distal upper limb amyotrophy (HP:0007149)2.20383111
61Round ear (HP:0100830)2.19630414
62Abnormality of oral frenula (HP:0000190)2.18227191
63Hyperparathyroidism (HP:0000843)2.18111354
64Deep palmar crease (HP:0006191)2.17686517
65Atrioventricular block (HP:0001678)2.16654047
66Truncus arteriosus (HP:0001660)2.16536351
67Hamartoma of the eye (HP:0010568)2.15868674
68Subaortic stenosis (HP:0001682)2.14997395
69Abnormality of the left ventricular outflow tract (HP:0011103)2.14997395
70Limb-girdle muscle atrophy (HP:0003797)2.12640001
71Fibrous tissue neoplasm (HP:0012316)2.12216100
72Abnormality of skeletal muscle fiber size (HP:0012084)2.10714385
73Resting tremor (HP:0002322)2.10606515
74Patellar dislocation (HP:0002999)2.09814882
75Sparse lateral eyebrow (HP:0005338)2.07329408
76Premature rupture of membranes (HP:0001788)2.05805034
77Ventricular fibrillation (HP:0001663)2.05564145
78Deviation of the thumb (HP:0009603)2.02378074
79Macroorchidism (HP:0000053)2.02101834
80Reticulocytosis (HP:0001923)2.01731749
81Ankyloglossia (HP:0010296)1.98529842
82Turricephaly (HP:0000262)1.98109807
83Broad metatarsal (HP:0001783)1.96120598
84Ragged-red muscle fibers (HP:0003200)1.95017247
85Proximal placement of thumb (HP:0009623)1.93880645
86Protrusio acetabuli (HP:0003179)1.92956095
87Progressive external ophthalmoplegia (HP:0000590)1.92909760
88EMG: neuropathic changes (HP:0003445)1.92748947
89Buphthalmos (HP:0000557)1.92655767
90Limb-girdle muscle weakness (HP:0003325)1.91770803
91Abnormality of the distal phalanges of the toes (HP:0010182)1.91208997
92Abnormality of the distal phalanx of the thumb (HP:0009617)1.90894711
93Bladder diverticulum (HP:0000015)1.90641275
94Heart block (HP:0012722)1.90425662
95Neoplasm of the heart (HP:0100544)1.89783754
96Myotonia (HP:0002486)1.89775842
97Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.89694629
98Short 4th metacarpal (HP:0010044)1.89694629
99Unilateral renal agenesis (HP:0000122)1.89639339
100Bowel incontinence (HP:0002607)1.88114078
101Deep venous thrombosis (HP:0002625)1.87841126
102Advanced eruption of teeth (HP:0006288)1.85262639
103Primary atrial arrhythmia (HP:0001692)1.85201115
104Lower limb amyotrophy (HP:0007210)1.85110796
105Septate vagina (HP:0001153)1.84676024
106Hyperthyroidism (HP:0000836)1.84040946
107Premature skin wrinkling (HP:0100678)1.83623161
108Bronchomalacia (HP:0002780)1.83408505
109Ulnar bowing (HP:0003031)1.82796296
110Hypercortisolism (HP:0001578)1.82679445
111Overlapping toe (HP:0001845)1.82029975
112Mitral valve prolapse (HP:0001634)1.81994858
113Mildly elevated creatine phosphokinase (HP:0008180)1.80942546
114Rectal prolapse (HP:0002035)1.80357797
115Abnormal atrioventricular conduction (HP:0005150)1.80256990
116Abnormality of the thoracic spine (HP:0100711)1.80189006
117Supraventricular arrhythmia (HP:0005115)1.79420948
118Abnormal large intestine physiology (HP:0012700)1.79084694
119Atrial fibrillation (HP:0005110)1.78743370
120Abnormality of reticulocytes (HP:0004312)1.77814394
121Distal lower limb amyotrophy (HP:0008944)1.77560147
122Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.77294881
123Spinal cord compression (HP:0002176)1.76957682
124Abnormality of the salivary glands (HP:0010286)1.76601066
125Ventricular arrhythmia (HP:0004308)1.76037720
126Orthostatic hypotension (HP:0001278)1.75404144
127Supraventricular tachycardia (HP:0004755)1.75358330
128Enlarged penis (HP:0000040)1.75149313
129Flat cornea (HP:0007720)1.74618751
130Bowel diverticulosis (HP:0005222)1.74254854
131Urinary urgency (HP:0000012)1.73800223
132Shoulder girdle muscle weakness (HP:0003547)1.73441448
133Distal lower limb muscle weakness (HP:0009053)1.73335369
134Increased nuchal translucency (HP:0010880)1.72315165
135Hand muscle atrophy (HP:0009130)1.72297333
136Abnormality of the diencephalon (HP:0010662)1.72195284
137Pelvic girdle muscle weakness (HP:0003749)1.71734611
138Spinal cord lesions (HP:0100561)1.71663784
139Syringomyelia (HP:0003396)1.71663784
140Aneurysm (HP:0002617)1.71135342
141Arnold-Chiari malformation (HP:0002308)1.70724757
142Coronal craniosynostosis (HP:0004440)1.70154084
143Annular pancreas (HP:0001734)1.69413709
144Progressive hearing impairment (HP:0001730)1.69304599
145Polygenic inheritance (HP:0010982)1.69184350
146Muscle fiber inclusion bodies (HP:0100299)1.68683782
147Increased density of long bones (HP:0006392)1.67835651
148Microvesicular hepatic steatosis (HP:0001414)1.65902348
149Cerebral inclusion bodies (HP:0100314)1.65887416
150Micronodular cirrhosis (HP:0001413)1.64535204
151Abnormality of the fingertips (HP:0001211)1.64061485
152Metaphyseal cupping (HP:0003021)1.63491972
153Mitral regurgitation (HP:0001653)1.62929649
154Hypercalcemia (HP:0003072)1.62562519
155Subacute progressive viral hepatitis (HP:0006572)1.61195201
156Abnormality of the calcaneus (HP:0008364)1.61124842
157Short nail (HP:0001799)1.60683450
158Relative macrocephaly (HP:0004482)1.59116945
159Fragile skin (HP:0001030)1.58612163
160Multiple enchondromatosis (HP:0005701)1.58318194
161Distal sensory impairment (HP:0002936)1.57353622
162Abnormal ossification of hand bones (HP:0005921)1.56445952
163Cellulitis (HP:0100658)1.55709736
164Myopathic facies (HP:0002058)1.55072644
165Urethral obstruction (HP:0000796)1.54512295
166Missing ribs (HP:0000921)1.53772810
167Elbow flexion contracture (HP:0002987)1.53697673
168Abnormality of the tricuspid valve (HP:0001702)1.53103230
169Depression (HP:0000716)1.52342639
170Hypokinesia (HP:0002375)1.51918549
171Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.51396526

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG15.05686932
2TRIB34.58405041
3PKN24.13837289
4EEF2K3.42881214
5TTN3.37867480
6PRPF4B3.17549611
7IRAK32.69623470
8MAP3K102.62083404
9NME22.47108513
10ICK2.42337737
11CDK122.19669457
12PDGFRA2.15501710
13NEK11.94694959
14ALK1.91393233
15TYRO31.76416405
16LATS21.69174575
17PHKG21.68443784
18PHKG11.68443784
19PTK61.66954721
20RIPK11.65390891
21PAK61.61687770
22LMTK21.57394239
23EPHA21.52801126
24KSR21.50786373
25VRK21.49282133
26FGFR41.49018184
27PRKD31.45398250
28BMX1.40479075
29DDR21.33732264
30DMPK1.32952307
31ARAF1.31243210
32MAP3K131.29987013
33BUB11.25319654
34SIK11.23412952
35MTOR1.19117429
36LATS11.18777140
37PAK21.17103032
38TAOK21.17005324
39LRRK21.12457312
40UHMK11.12209505
41CDK71.12017413
42CAMK1G1.11255457
43MAP3K71.11025610
44RPS6KB21.10425632
45SCYL21.08092630
46TLK11.04966195
47MAP3K91.03472721
48MST1R1.02320942
49ILK0.98955920
50RET0.98925309
51CDC70.98840556
52TESK10.96973151
53TAF10.96221441
54TESK20.95035710
55PAK30.94672659
56BRAF0.93927389
57MAPK110.90833326
58TAOK10.86335156
59EIF2AK10.85390620
60BRSK10.84562826
61PNCK0.81456163
62IRAK20.79681385
63MAP3K40.78863341
64PRKD10.77325120
65TSSK60.76801006
66CAMK1D0.75669915
67NEK20.75162701
68EPHB20.74743743
69KSR10.74575244
70CDC42BPA0.73898768
71PDPK10.72886281
72CDK60.72854698
73CHEK20.72151308
74SIK20.71655879
75CAMKK10.71576491
76MAP3K10.71172242
77CDK40.70794608
78MAP2K30.70761676
79ROCK20.70564662
80NTRK30.70445848
81PDGFRB0.70403667
82FGFR10.69350631
83WNK10.68009694
84CSNK1E0.67967087
85EPHB10.67709803
86AURKA0.67532383
87PAK40.67389988
88DAPK30.67163113
89NTRK10.66686099
90MAP2K20.66630837
91MAP3K80.66042824
92AKT20.65595400
93PRKCH0.64079977
94PTK20.63930464
95FGFR20.63251886
96STK380.62789565
97OBSCN0.61975176
98CSNK1D0.61935990
99CDK90.61520894
100PDK30.61167959
101PDK40.61167959
102MAP2K40.60433859
103DAPK10.58686109
104ERN10.57990387
105CDK80.57510123
106STK110.56264281
107CDK150.54711950
108PASK0.53485996
109MINK10.52683780
110HIPK20.52025095
111RIPK40.51382402
112ROCK10.51035580
113MAP3K20.50376384
114CDK140.49434128
115CDK11A0.48754253
116MAP3K110.48749885
117MAP3K140.48204506
118MARK10.47429789
119GRK60.46496604
120FER0.46067181
121MARK20.45582981
122ERBB20.44880495
123SRPK10.44621104
124CDK20.44137292
125CDK180.43778516
126AURKB0.43684202
127RPS6KA10.42753222
128MELK0.42664183
129CHEK10.42363425
130NTRK20.42191081
131DAPK20.41512461
132BRD40.40715683
133FGR0.40332203
134ATR0.40032821
135RAF10.39665739
136DYRK1B0.39554307
137TTK0.39413930
138STK40.39226027
139CDK10.38308891
140PRKDC0.38026902
141RPS6KA30.37700421
142RPS6KA20.37528464
143IRAK40.36356006
144PDK10.36032243
145SIK30.35279988
146RPS6KL10.34985655
147RPS6KC10.34985655

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.47811059
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.41497611
3DNA replication_Homo sapiens_hsa030302.87687323
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.71131058
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.13612986
6Pentose phosphate pathway_Homo sapiens_hsa000301.91857394
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.90465456
8Arginine biosynthesis_Homo sapiens_hsa002201.84110432
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.83375732
10Dilated cardiomyopathy_Homo sapiens_hsa054141.76316808
11Acute myeloid leukemia_Homo sapiens_hsa052211.74828147
12Pancreatic cancer_Homo sapiens_hsa052121.71279249
13Biosynthesis of amino acids_Homo sapiens_hsa012301.67123476
14Cell cycle_Homo sapiens_hsa041101.65095930
15Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.63111569
16Lysine degradation_Homo sapiens_hsa003101.57967499
17* Spliceosome_Homo sapiens_hsa030401.57179580
18Carbon metabolism_Homo sapiens_hsa012001.56040047
19Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.55897256
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.49667329
21Base excision repair_Homo sapiens_hsa034101.49199636
22Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.46381771
23Vitamin B6 metabolism_Homo sapiens_hsa007501.45563778
24Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.43726901
25mTOR signaling pathway_Homo sapiens_hsa041501.42515237
26Central carbon metabolism in cancer_Homo sapiens_hsa052301.41770723
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.39981533
28Fructose and mannose metabolism_Homo sapiens_hsa000511.39944481
29Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.38722716
30Ribosome_Homo sapiens_hsa030101.37119706
31Fatty acid degradation_Homo sapiens_hsa000711.34312307
32Sulfur relay system_Homo sapiens_hsa041221.30883013
33Fatty acid metabolism_Homo sapiens_hsa012121.28568032
34Basal cell carcinoma_Homo sapiens_hsa052171.27849977
35Glioma_Homo sapiens_hsa052141.27600612
36B cell receptor signaling pathway_Homo sapiens_hsa046621.26984318
37Cardiac muscle contraction_Homo sapiens_hsa042601.26850345
38Butanoate metabolism_Homo sapiens_hsa006501.26433021
39Other glycan degradation_Homo sapiens_hsa005111.15909054
40Tight junction_Homo sapiens_hsa045301.15428246
41Estrogen signaling pathway_Homo sapiens_hsa049151.15149917
42Insulin signaling pathway_Homo sapiens_hsa049101.14904566
43Chronic myeloid leukemia_Homo sapiens_hsa052201.12492620
44Proteoglycans in cancer_Homo sapiens_hsa052051.11925261
45Bladder cancer_Homo sapiens_hsa052191.11713501
46RNA transport_Homo sapiens_hsa030131.11342525
47Hippo signaling pathway_Homo sapiens_hsa043901.10419844
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.09255206
49Dorso-ventral axis formation_Homo sapiens_hsa043201.08333066
50Focal adhesion_Homo sapiens_hsa045101.08260961
51Hedgehog signaling pathway_Homo sapiens_hsa043401.08177771
52Prostate cancer_Homo sapiens_hsa052151.06562288
53Glucagon signaling pathway_Homo sapiens_hsa049221.05973506
54Propanoate metabolism_Homo sapiens_hsa006401.05703964
55Viral carcinogenesis_Homo sapiens_hsa052031.04681693
56Non-small cell lung cancer_Homo sapiens_hsa052231.04527310
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.04469508
58One carbon pool by folate_Homo sapiens_hsa006701.03476469
59AMPK signaling pathway_Homo sapiens_hsa041521.03377609
60Renal cell carcinoma_Homo sapiens_hsa052111.03098648
61Fatty acid biosynthesis_Homo sapiens_hsa000611.02521646
62Gap junction_Homo sapiens_hsa045401.02517871
63Bile secretion_Homo sapiens_hsa049761.02148976
64Thyroid hormone signaling pathway_Homo sapiens_hsa049191.01053595
65Mismatch repair_Homo sapiens_hsa034301.00991736
66Insulin resistance_Homo sapiens_hsa049311.00690381
67Endometrial cancer_Homo sapiens_hsa052130.99494218
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.98644801
69Type II diabetes mellitus_Homo sapiens_hsa049300.97397910
70VEGF signaling pathway_Homo sapiens_hsa043700.95478368
71Hepatitis B_Homo sapiens_hsa051610.94899501
72Galactose metabolism_Homo sapiens_hsa000520.93049758
73Notch signaling pathway_Homo sapiens_hsa043300.91159812
74Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.91009047
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.89624136
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.89579547
77Long-term potentiation_Homo sapiens_hsa047200.89486286
78Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.87933262
79Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.87637308
80Apoptosis_Homo sapiens_hsa042100.87353573
81Adherens junction_Homo sapiens_hsa045200.86891531
82Viral myocarditis_Homo sapiens_hsa054160.86879020
83HTLV-I infection_Homo sapiens_hsa051660.86219437
84Melanogenesis_Homo sapiens_hsa049160.85797628
85mRNA surveillance pathway_Homo sapiens_hsa030150.85441063
86Gastric acid secretion_Homo sapiens_hsa049710.84419062
87Axon guidance_Homo sapiens_hsa043600.84295569
88Pyruvate metabolism_Homo sapiens_hsa006200.83467350
89Oxytocin signaling pathway_Homo sapiens_hsa049210.83264341
90Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.83253138
91MicroRNAs in cancer_Homo sapiens_hsa052060.82716661
92Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.81494296
93GnRH signaling pathway_Homo sapiens_hsa049120.81444260
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.81176533
95Nucleotide excision repair_Homo sapiens_hsa034200.79307620
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79214557
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76630271
98AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76302552
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.76044148
100N-Glycan biosynthesis_Homo sapiens_hsa005100.75798048
101Vibrio cholerae infection_Homo sapiens_hsa051100.75289745
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.75203491
103Tryptophan metabolism_Homo sapiens_hsa003800.75073109
104Inositol phosphate metabolism_Homo sapiens_hsa005620.74830641
105Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.73576396
106Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73084419
107cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71547235
108ErbB signaling pathway_Homo sapiens_hsa040120.71321957
109Aldosterone synthesis and secretion_Homo sapiens_hsa049250.70627066
110Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.70505231
111Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69730165
112Epstein-Barr virus infection_Homo sapiens_hsa051690.69156950
113PPAR signaling pathway_Homo sapiens_hsa033200.68932325
114Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.68870839
115Hepatitis C_Homo sapiens_hsa051600.67433684
116Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67217325
117Neurotrophin signaling pathway_Homo sapiens_hsa047220.66685088
118Shigellosis_Homo sapiens_hsa051310.65790500
119Prolactin signaling pathway_Homo sapiens_hsa049170.65379968
120Choline metabolism in cancer_Homo sapiens_hsa052310.64351502
121Wnt signaling pathway_Homo sapiens_hsa043100.64188255
122Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.63506572
123Oocyte meiosis_Homo sapiens_hsa041140.62207960
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.61598652
125Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61333357
126Primary bile acid biosynthesis_Homo sapiens_hsa001200.61295059
127Pyrimidine metabolism_Homo sapiens_hsa002400.61211304
128Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60743560
129Sphingolipid signaling pathway_Homo sapiens_hsa040710.57996700
130Colorectal cancer_Homo sapiens_hsa052100.57908794
131Dopaminergic synapse_Homo sapiens_hsa047280.56987736
132Thyroid cancer_Homo sapiens_hsa052160.56764003
133Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.56705407
134Prion diseases_Homo sapiens_hsa050200.56023497
135ECM-receptor interaction_Homo sapiens_hsa045120.54706807
136Insulin secretion_Homo sapiens_hsa049110.52499116
137Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52375530
138Amoebiasis_Homo sapiens_hsa051460.52125901
139Selenocompound metabolism_Homo sapiens_hsa004500.51785593
140Endocytosis_Homo sapiens_hsa041440.50492481
141Rap1 signaling pathway_Homo sapiens_hsa040150.50418284
142Renin secretion_Homo sapiens_hsa049240.50322252
143Phenylalanine metabolism_Homo sapiens_hsa003600.50181255
144Synaptic vesicle cycle_Homo sapiens_hsa047210.49452513
145HIF-1 signaling pathway_Homo sapiens_hsa040660.48986415
146Small cell lung cancer_Homo sapiens_hsa052220.48760781
147Melanoma_Homo sapiens_hsa052180.48555108
148Herpes simplex infection_Homo sapiens_hsa051680.45765654
149Influenza A_Homo sapiens_hsa051640.45660168
150Arginine and proline metabolism_Homo sapiens_hsa003300.44378078
151Cysteine and methionine metabolism_Homo sapiens_hsa002700.43751533

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