PRPF3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The removal of introns from nuclear pre-mRNAs occurs on complexes called spliceosomes, which are made up of 4 small nuclear ribonucleoprotein (snRNP) particles and an undefined number of transiently associated splicing factors. This gene product is one of several proteins that associate with U4 and U6 snRNPs. Mutations in this gene are associated with retinitis pigmentosa-18. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)4.76753037
2DNA strand elongation involved in DNA replication (GO:0006271)4.48883223
3regulation of DNA damage checkpoint (GO:2000001)4.47136879
4DNA replication initiation (GO:0006270)4.44880270
5DNA unwinding involved in DNA replication (GO:0006268)4.44193063
6nuclear pore organization (GO:0006999)4.43103055
7DNA replication checkpoint (GO:0000076)4.37521724
8mitotic metaphase plate congression (GO:0007080)4.31930176
9DNA strand elongation (GO:0022616)4.31276734
10nuclear pore complex assembly (GO:0051292)4.21612331
11mitotic nuclear envelope disassembly (GO:0007077)4.13795649
12telomere maintenance via semi-conservative replication (GO:0032201)4.12551512
13metaphase plate congression (GO:0051310)3.97620694
14protein localization to chromosome, centromeric region (GO:0071459)3.96287182
15nucleobase biosynthetic process (GO:0046112)3.92841156
16maturation of SSU-rRNA (GO:0030490)3.84890458
17mitotic sister chromatid segregation (GO:0000070)3.84780474
18IMP biosynthetic process (GO:0006188)3.84360757
19telomere maintenance via recombination (GO:0000722)3.81608970
20formation of translation preinitiation complex (GO:0001731)3.81278510
21nuclear envelope disassembly (GO:0051081)3.80419544
22membrane disassembly (GO:0030397)3.80419544
23DNA replication-dependent nucleosome organization (GO:0034723)3.80105462
24DNA replication-dependent nucleosome assembly (GO:0006335)3.80105462
25chromatin remodeling at centromere (GO:0031055)3.75017240
26kinetochore organization (GO:0051383)3.70904999
27CENP-A containing nucleosome assembly (GO:0034080)3.70006349
28purine nucleobase biosynthetic process (GO:0009113)3.69995087
29mitotic recombination (GO:0006312)3.67445724
30regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.60459509
31attachment of spindle microtubules to kinetochore (GO:0008608)3.60258270
32regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.60255854
33regulation of mitotic spindle checkpoint (GO:1903504)3.60255854
34regulation of spindle organization (GO:0090224)3.52685446
35ribosome biogenesis (GO:0042254)3.52122886
36regulation of centriole replication (GO:0046599)3.50951315
37DNA replication-independent nucleosome organization (GO:0034724)3.50894269
38DNA replication-independent nucleosome assembly (GO:0006336)3.50894269
39mitotic chromosome condensation (GO:0007076)3.50389643
40sister chromatid segregation (GO:0000819)3.49988514
41establishment of chromosome localization (GO:0051303)3.48978087
42response to UV-C (GO:0010225)3.48274990
43telomere maintenance via telomere lengthening (GO:0010833)3.47925202
44meiotic chromosome segregation (GO:0045132)3.44966101
45nucleotide-excision repair, DNA gap filling (GO:0006297)3.41094745
46DNA geometric change (GO:0032392)3.38727709
47inner cell mass cell proliferation (GO:0001833)3.38654754
48DNA duplex unwinding (GO:0032508)3.38290624
49regulation of helicase activity (GO:0051095)3.35727506
50regulation of RNA export from nucleus (GO:0046831)3.34601658
51folic acid-containing compound biosynthetic process (GO:0009396)3.32176420
52kinetochore assembly (GO:0051382)3.30451647
53regulation of mitotic spindle organization (GO:0060236)3.29464296
54ribosomal large subunit biogenesis (GO:0042273)3.28610973
55mismatch repair (GO:0006298)3.26696290
56ribosome assembly (GO:0042255)3.26467240
57ribonucleoprotein complex biogenesis (GO:0022613)3.23347647
58histone H3-K9 methylation (GO:0051567)3.21102731
59protein K11-linked deubiquitination (GO:0035871)3.20548956
60rRNA catabolic process (GO:0016075)3.19861738
61somatic diversification of immune receptors via somatic mutation (GO:0002566)3.19758983
62somatic hypermutation of immunoglobulin genes (GO:0016446)3.19758983
63necroptotic process (GO:0070266)3.18388019
64regulation of cell cycle checkpoint (GO:1901976)3.18151508
65histone exchange (GO:0043486)3.17798966
66mitotic sister chromatid cohesion (GO:0007064)3.15827082
67pore complex assembly (GO:0046931)3.15699943
68tRNA methylation (GO:0030488)3.14835657
69regulation of nuclear cell cycle DNA replication (GO:0033262)3.14140171
70IMP metabolic process (GO:0046040)3.14015492
71negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.12684606
72rRNA processing (GO:0006364)3.12521368
73establishment of integrated proviral latency (GO:0075713)3.09342069
74RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.09276817
75intra-S DNA damage checkpoint (GO:0031573)3.08795796
76maturation of 5.8S rRNA (GO:0000460)3.07080274
77* RNA splicing, via transesterification reactions (GO:0000375)3.06200113
78* mRNA splicing, via spliceosome (GO:0000398)3.06149390
79* RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.06149390
80piRNA metabolic process (GO:0034587)3.03603770
81rRNA metabolic process (GO:0016072)3.03358183
82positive regulation of cell cycle checkpoint (GO:1901978)3.03216529
83spindle checkpoint (GO:0031577)3.01628784
84negative regulation of chromosome segregation (GO:0051985)3.00850375
85regulation of chromosome segregation (GO:0051983)3.00259370
86negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.98800871
87negative regulation of sister chromatid segregation (GO:0033046)2.98800871
88negative regulation of mitotic sister chromatid separation (GO:2000816)2.98800871
89negative regulation of mitotic sister chromatid segregation (GO:0033048)2.98800871
90regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.98645777
91* spliceosomal snRNP assembly (GO:0000387)2.98134707
92positive regulation of chromosome segregation (GO:0051984)2.97484048
93ribosomal small subunit assembly (GO:0000028)2.97209278
94spindle assembly checkpoint (GO:0071173)2.96717824
95regulation of mitotic metaphase/anaphase transition (GO:0030071)2.96474206
96histone H3-K9 modification (GO:0061647)2.95691288
97DNA methylation involved in gamete generation (GO:0043046)2.95357664
98RNA methylation (GO:0001510)2.95179320
99chromatin assembly or disassembly (GO:0006333)2.94491394
100regulation of nucleobase-containing compound transport (GO:0032239)2.94290432
101protein localization to chromosome (GO:0034502)2.94049795
102antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.93022194
103regulation of centrosome cycle (GO:0046605)2.92277884
104heterochromatin organization (GO:0070828)2.91976602
105regulation of histone H3-K9 methylation (GO:0051570)2.91294947
106mitotic spindle assembly checkpoint (GO:0007094)2.91049605
107protein K6-linked ubiquitination (GO:0085020)2.90569389
108chromosome segregation (GO:0007059)2.89888980
109spliceosomal complex assembly (GO:0000245)2.89774617
110negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.89194991
111regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.89104359
112mitotic spindle checkpoint (GO:0071174)2.88320231
113nuclear envelope organization (GO:0006998)2.88046882
114RNA export from nucleus (GO:0006405)2.88044889
115viral mRNA export from host cell nucleus (GO:0046784)2.87975074
116telomere organization (GO:0032200)2.86764791
117mRNA export from nucleus (GO:0006406)2.86594386
118DNA conformation change (GO:0071103)2.85241442
119ATP-dependent chromatin remodeling (GO:0043044)2.85103931
120regulation of gene silencing by RNA (GO:0060966)2.85060284
121regulation of posttranscriptional gene silencing (GO:0060147)2.85060284
122regulation of gene silencing by miRNA (GO:0060964)2.85060284
123monoubiquitinated protein deubiquitination (GO:0035520)2.81689445
124pseudouridine synthesis (GO:0001522)2.80173198
125regulation of spindle checkpoint (GO:0090231)2.77701008
126somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.75980030
127somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.75980030
128isotype switching (GO:0045190)2.75980030
129peptidyl-lysine trimethylation (GO:0018023)2.74343086
130somatic diversification of immunoglobulins (GO:0016445)2.74234124
131regulation of centrosome duplication (GO:0010824)2.72212221
132DNA catabolic process, exonucleolytic (GO:0000738)2.70847048
133positive regulation of G1/S transition of mitotic cell cycle (GO:1900087)2.70706395
134sister chromatid cohesion (GO:0007062)2.70650874
135synapsis (GO:0007129)2.70221524
136negative regulation of translation, ncRNA-mediated (GO:0040033)2.67763376
137regulation of translation, ncRNA-mediated (GO:0045974)2.67763376
138negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.67763376
139negative regulation of DNA-dependent DNA replication (GO:2000104)2.63448406
140antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.60831487
141somatic diversification of immune receptors (GO:0002200)2.59355468
142hepatocyte apoptotic process (GO:0097284)2.52584332
143NIK/NF-kappaB signaling (GO:0038061)2.52300089
144telomere maintenance (GO:0000723)2.51748960
145gene silencing by RNA (GO:0031047)2.51733300
146double-strand break repair via homologous recombination (GO:0000724)2.51498596
147recombinational repair (GO:0000725)2.47565910
148translesion synthesis (GO:0019985)2.47072968
149tRNA modification (GO:0006400)2.46856975
150negative regulation of DNA repair (GO:0045738)2.46247648
151regulation of interferon-alpha production (GO:0032647)2.45859715
152positive regulation of cell cycle G1/S phase transition (GO:1902808)2.45790655
153necrotic cell death (GO:0070265)2.44715538
154mRNA transport (GO:0051028)2.43593521
155DNA replication (GO:0006260)2.42997836
156DNA-dependent DNA replication (GO:0006261)2.42743972
157programmed necrotic cell death (GO:0097300)2.42635403
158somatic recombination of immunoglobulin gene segments (GO:0016447)2.41942355

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.57976596
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.58383056
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.20722872
4E2F4_17652178_ChIP-ChIP_JURKAT_Human4.11853190
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.35969477
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.34394953
7* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.06996012
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.95935994
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.93236281
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.89331636
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.75949994
12GATA1_22025678_ChIP-Seq_K562_Human2.74146646
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.64706666
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.63295555
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.62494211
16* GABP_17652178_ChIP-ChIP_JURKAT_Human2.56184327
17* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.47579111
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.47484190
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.47207971
20* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.34770374
21* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.34169826
22XRN2_22483619_ChIP-Seq_HELA_Human2.31441529
23EGR1_19374776_ChIP-ChIP_THP-1_Human2.25945889
24E2F1_21310950_ChIP-Seq_MCF-7_Human2.18549144
25VDR_23849224_ChIP-Seq_CD4+_Human2.17422211
26AR_21909140_ChIP-Seq_LNCAP_Human2.16407637
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.14615414
28IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.13655215
29* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.08796821
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.97187529
31FOXP3_21729870_ChIP-Seq_TREG_Human1.97076512
32YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.95576799
33* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.95126438
34NANOG_18555785_ChIP-Seq_MESCs_Mouse1.91507624
35E2F1_18555785_ChIP-Seq_MESCs_Mouse1.90687362
36TTF2_22483619_ChIP-Seq_HELA_Human1.89604076
37DCP1A_22483619_ChIP-Seq_HELA_Human1.88312722
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.86407037
39IRF8_21731497_ChIP-ChIP_J774_Mouse1.85497874
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.84572588
41CIITA_25753668_ChIP-Seq_RAJI_Human1.76444074
42* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75620337
43TP63_19390658_ChIP-ChIP_HaCaT_Human1.73146570
44* ELK1_19687146_ChIP-ChIP_HELA_Human1.72741069
45* GABP_19822575_ChIP-Seq_HepG2_Human1.69657399
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.63347541
47MYC_22102868_ChIP-Seq_BL_Human1.63049367
48* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.62835536
49NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.59374730
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.56790657
51ZNF274_21170338_ChIP-Seq_K562_Hela1.55477609
52* KDM5A_27292631_Chip-Seq_BREAST_Human1.51583201
53CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.49529065
54* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.45791670
55TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.41646911
56ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.41444426
57STAT4_19710469_ChIP-ChIP_TH1__Mouse1.41174775
58* MYB_26560356_Chip-Seq_TH1_Human1.40970079
59ZFX_18555785_ChIP-Seq_MESCs_Mouse1.40687985
60* YY1_21170310_ChIP-Seq_MESCs_Mouse1.40184561
61MYB_26560356_Chip-Seq_TH2_Human1.39558193
62CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.38426292
63PKCTHETA_26484144_Chip-Seq_BREAST_Human1.37750275
64SOX2_18555785_ChIP-Seq_MESCs_Mouse1.37093448
65STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.36889801
66HOXB4_20404135_ChIP-ChIP_EML_Mouse1.35624075
67PADI4_21655091_ChIP-ChIP_MCF-7_Human1.33910987
68BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.33637447
69TFEB_21752829_ChIP-Seq_HELA_Human1.29240493
70SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.28953331
71POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.28830561
72POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.28501245
73SALL1_21062744_ChIP-ChIP_HESCs_Human1.26739378
74GATA3_26560356_Chip-Seq_TH2_Human1.26177048
75FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.24536090
76IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.22466151
77NOTCH1_21737748_ChIP-Seq_TLL_Human1.20481238
78ESR1_20079471_ChIP-ChIP_T-47D_Human1.19480280
79SRF_21415370_ChIP-Seq_HL-1_Mouse1.19341500
80SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.19194959
81CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.17260778
82E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17023233
83MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.17018802
84STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.15705767
85ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.13932469
86RBPJ_22232070_ChIP-Seq_NCS_Mouse1.11260570
87STAT3_1855785_ChIP-Seq_MESCs_Mouse1.10719309
88CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.09906957
89KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.09791551
90KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.09791551
91KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.09791551
92* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08809210
93SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.05785505
94E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.05774739
95ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04973502
96ERG_20887958_ChIP-Seq_HPC-7_Mouse1.04758103
97NANOG_21062744_ChIP-ChIP_HESCs_Human1.04365769
98KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04069109
99ELF5_23300383_ChIP-Seq_T47D_Human1.01311090
100SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.01130068
101* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.99602901
102ESR1_21235772_ChIP-Seq_MCF-7_Human0.98896723
103* PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.97920569
104CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.97633586
105MYC_18940864_ChIP-ChIP_HL60_Human0.95955501
106TCF3_18692474_ChIP-Seq_MEFs_Mouse0.95923987
107DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95335070
108FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.95125892
109ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93918650
110DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.90767627
111BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.90689622
112HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.90002134
113NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.89068984
114* MAF_26560356_Chip-Seq_TH1_Human0.86755906
115* NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.86556755
116CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.85623428
117ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.85232423
118SMAD_19615063_ChIP-ChIP_OVARY_Human0.85208657
119SPI1_23547873_ChIP-Seq_NB4_Human0.82955253
120GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.82840687
121GATA3_27048872_Chip-Seq_THYMUS_Human0.82688809
122* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80139764
123* IRF8_27001747_Chip-Seq_BMDM_Mouse0.79717085
124MAF_26560356_Chip-Seq_TH2_Human0.79676631
125NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.79565469
126CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.79547219
127CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.79498749
128SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.78265920
129VDR_21846776_ChIP-Seq_THP-1_Human0.77644312
130* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.77244189
131KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.76654978

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.78787153
2MP0003693_abnormal_embryo_hatching4.69067375
3MP0003111_abnormal_nucleus_morphology4.49811469
4MP0008057_abnormal_DNA_replication4.29049400
5MP0004957_abnormal_blastocyst_morpholog3.99023555
6MP0003077_abnormal_cell_cycle3.96270795
7MP0008058_abnormal_DNA_repair3.32492976
8MP0008007_abnormal_cellular_replicative3.26450638
9MP0008877_abnormal_DNA_methylation2.68140634
10MP0003123_paternal_imprinting2.62393861
11MP0008932_abnormal_embryonic_tissue2.56650598
12MP0000350_abnormal_cell_proliferation2.32048382
13MP0001730_embryonic_growth_arrest2.30853342
14MP0002396_abnormal_hematopoietic_system2.22070478
15MP0003656_abnormal_erythrocyte_physiolo1.96400222
16MP0010030_abnormal_orbit_morphology1.92009016
17MP0010307_abnormal_tumor_latency1.89136816
18MP0001835_abnormal_antigen_presentation1.88361502
19MP0003121_genomic_imprinting1.88041893
20MP0001672_abnormal_embryogenesis/_devel1.85558813
21MP0005380_embryogenesis_phenotype1.85558813
22MP0003786_premature_aging1.81259406
23MP0010352_gastrointestinal_tract_polyps1.79637746
24MP0001697_abnormal_embryo_size1.76098630
25MP0002009_preneoplasia1.72862634
26MP0003646_muscle_fatigue1.67863223
27MP0000383_abnormal_hair_follicle1.67016284
28MP0009785_altered_susceptibility_to1.66357181
29MP0005671_abnormal_response_to1.66222230
30MP0003984_embryonic_growth_retardation1.66089387
31MP0002085_abnormal_embryonic_tissue1.63096796
32MP0002088_abnormal_embryonic_growth/wei1.61939407
33MP0005075_abnormal_melanosome_morpholog1.58371773
34MP0001800_abnormal_humoral_immune1.57709274
35* MP0002080_prenatal_lethality1.55710196
36MP0004197_abnormal_fetal_growth/weight/1.55687989
37MP0004381_abnormal_hair_follicle1.55108461
38MP0002084_abnormal_developmental_patter1.54208611
39MP0003436_decreased_susceptibility_to1.53534111
40MP0000490_abnormal_crypts_of1.53409731
41MP0000569_abnormal_digit_pigmentation1.49306772
42MP0004233_abnormal_muscle_weight1.45401075
43MP0003890_abnormal_embryonic-extraembry1.43755079
44MP0002653_abnormal_ependyma_morphology1.43275038
45MP0002086_abnormal_extraembryonic_tissu1.43269873
46MP0000313_abnormal_cell_death1.39923891
47MP0003567_abnormal_fetal_cardiomyocyte1.39577358
48MP0006292_abnormal_olfactory_placode1.39410258
49MP0002210_abnormal_sex_determination1.37101414
50MP0008260_abnormal_autophagy1.36958317
51MP0005000_abnormal_immune_tolerance1.35081799
52MP0004808_abnormal_hematopoietic_stem1.34883974
53MP0002452_abnormal_antigen_presenting1.33279257
54MP0003136_yellow_coat_color1.31631729
55MP0001293_anophthalmia1.29670303
56MP0000427_abnormal_hair_cycle1.29220821
57MP0000372_irregular_coat_pigmentation1.29072534
58MP0002019_abnormal_tumor_incidence1.27683931
59MP0002723_abnormal_immune_serum1.24533533
60MP0002148_abnormal_hypersensitivity_rea1.23922704
61MP0010678_abnormal_skin_adnexa1.22916455
62MP0004185_abnormal_adipocyte_glucose1.22030309
63MP0002420_abnormal_adaptive_immunity1.21048776
64MP0005076_abnormal_cell_differentiation1.20896075
65MP0001819_abnormal_immune_cell1.20420670
66MP0000537_abnormal_urethra_morphology1.19045339
67MP0003718_maternal_effect1.18727359
68MP0008995_early_reproductive_senescence1.18089727
69MP0003941_abnormal_skin_development1.17923235
70MP0000703_abnormal_thymus_morphology1.17004772
71MP0001145_abnormal_male_reproductive1.15374259
72MP0002132_abnormal_respiratory_system1.13570225
73MP0000685_abnormal_immune_system1.10824564
74MP0000015_abnormal_ear_pigmentation1.10539374
75MP0002419_abnormal_innate_immunity1.10177841
76MP0003763_abnormal_thymus_physiology1.07091408
77MP0009764_decreased_sensitivity_to1.06394353
78MP0005025_abnormal_response_to1.05938326
79MP0004947_skin_inflammation1.04991379
80MP0003172_abnormal_lysosome_physiology1.04125137
81MP0002254_reproductive_system_inflammat1.04098797
82MP0003943_abnormal_hepatobiliary_system1.01713429
83MP0002405_respiratory_system_inflammati1.01592618
84MP0001853_heart_inflammation1.01380167
85MP0003119_abnormal_digestive_system0.98954830
86MP0004133_heterotaxia0.98692212
87MP0006082_CNS_inflammation0.97627163
88MP0002398_abnormal_bone_marrow0.97575569
89MP0001929_abnormal_gametogenesis0.97073161
90MP0003303_peritoneal_inflammation0.96679659
91MP0000653_abnormal_sex_gland0.96637964
92MP0002006_tumorigenesis0.95971915
93MP0001915_intracranial_hemorrhage0.95592708
94MP0001790_abnormal_immune_system0.94307041
95MP0005387_immune_system_phenotype0.94307041
96MP0003315_abnormal_perineum_morphology0.93504877
97MP0009053_abnormal_anal_canal0.93386822
98MP0009333_abnormal_splenocyte_physiolog0.93374303
99MP0005266_abnormal_metabolism0.93172293
100MP0009672_abnormal_birth_weight0.92324845
101MP0002166_altered_tumor_susceptibility0.92255915
102MP0002138_abnormal_hepatobiliary_system0.91701769
103MP0002722_abnormal_immune_system0.91615368
104MP0008872_abnormal_physiological_respon0.90328112
105MP0003937_abnormal_limbs/digits/tail_de0.87934326
106MP0001119_abnormal_female_reproductive0.85453766
107MP0001286_abnormal_eye_development0.84336102
108MP0003724_increased_susceptibility_to0.84323099
109MP0000689_abnormal_spleen_morphology0.84294872
110MP0001873_stomach_inflammation0.84051694
111MP0004147_increased_porphyrin_level0.83765329
112MP0002160_abnormal_reproductive_system0.83510715
113MP0002111_abnormal_tail_morphology0.83278746
114MP0000428_abnormal_craniofacial_morphol0.81927178
115MP0010155_abnormal_intestine_physiology0.81894634
116MP0002938_white_spotting0.80545043
117MP0001243_abnormal_dermal_layer0.80314436
118MP0003300_gastrointestinal_ulcer0.78959788
119MP0001845_abnormal_inflammatory_respons0.78101877
120MP0005367_renal/urinary_system_phenotyp0.77827826
121MP0000516_abnormal_urinary_system0.77827826
122MP0001849_ear_inflammation0.77635608
123MP0009703_decreased_birth_body0.76930084
124MP0001216_abnormal_epidermal_layer0.75312859
125MP0003566_abnormal_cell_adhesion0.74876427
126MP0005384_cellular_phenotype0.73807882
127MP0002075_abnormal_coat/hair_pigmentati0.71884857
128MP0005621_abnormal_cell_physiology0.71202809
129MP0002092_abnormal_eye_morphology0.70763703
130MP0002429_abnormal_blood_cell0.70234711
131MP0003787_abnormal_imprinting0.69013164
132MP0000432_abnormal_head_morphology0.67134139
133MP0003806_abnormal_nucleotide_metabolis0.66589561
134MP0005397_hematopoietic_system_phenotyp0.65815284
135MP0001545_abnormal_hematopoietic_system0.65815284
136MP0000049_abnormal_middle_ear0.63699219
137MP0005389_reproductive_system_phenotype0.62986683
138MP0003115_abnormal_respiratory_system0.62979338
139MP0003755_abnormal_palate_morphology0.61844718
140MP0000858_altered_metastatic_potential0.61008790
141MP0000371_diluted_coat_color0.60531228
142MP0001186_pigmentation_phenotype0.57787775
143MP0002925_abnormal_cardiovascular_devel0.57595682
144MP0002089_abnormal_postnatal_growth/wei0.56587679
145MP0002697_abnormal_eye_size0.56285487
146MP0008789_abnormal_olfactory_epithelium0.56051438
147MP0003122_maternal_imprinting0.56031627
148MP0000716_abnormal_immune_system0.56025036
149MP0005023_abnormal_wound_healing0.54872035
150MP0001919_abnormal_reproductive_system0.54363793
151MP0008770_decreased_survivor_rate0.54244960
152MP0003935_abnormal_craniofacial_develop0.53921551
153MP0003221_abnormal_cardiomyocyte_apopto0.53911314
154MP0002102_abnormal_ear_morphology0.53571547

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.17983958
2Chromsome breakage (HP:0040012)4.24218231
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.10973049
4Neoplasm of the adrenal cortex (HP:0100641)4.00103127
5Breast hypoplasia (HP:0003187)3.63531521
6Reticulocytopenia (HP:0001896)3.61220373
7Selective tooth agenesis (HP:0001592)3.60839406
8Medulloblastoma (HP:0002885)3.60323989
9Ependymoma (HP:0002888)3.47746821
10Patellar aplasia (HP:0006443)3.43715820
11Meckel diverticulum (HP:0002245)3.34110069
12Abnormality of chromosome stability (HP:0003220)3.30053782
13Abnormality of the ileum (HP:0001549)3.29156030
14Aplasia/Hypoplasia of the patella (HP:0006498)3.18656030
15Acute myeloid leukemia (HP:0004808)3.09490073
16Abnormality of the preputium (HP:0100587)3.07897765
17Colon cancer (HP:0003003)3.03619886
18Aplasia/Hypoplasia of the uvula (HP:0010293)3.02086630
19Absent radius (HP:0003974)2.99157949
20Abnormality of the labia minora (HP:0012880)2.97096526
21Degeneration of anterior horn cells (HP:0002398)2.96679532
22Abnormality of the anterior horn cell (HP:0006802)2.96679532
23Impulsivity (HP:0100710)2.94101742
24Agnosia (HP:0010524)2.92194088
25Abnormal number of incisors (HP:0011064)2.89377473
26Carpal bone hypoplasia (HP:0001498)2.84989542
27Absent forearm bone (HP:0003953)2.82646478
28Aplasia involving forearm bones (HP:0009822)2.82646478
29Myelodysplasia (HP:0002863)2.75003271
30Ectopic kidney (HP:0000086)2.72079929
31Small intestinal stenosis (HP:0012848)2.70850517
32Duodenal stenosis (HP:0100867)2.70850517
33Abnormality of the pons (HP:0007361)2.69255939
34Absent thumb (HP:0009777)2.67499233
35Stomach cancer (HP:0012126)2.62326401
36Aplastic anemia (HP:0001915)2.53050458
37Rough bone trabeculation (HP:0100670)2.50686884
38Curly hair (HP:0002212)2.49951251
39Supernumerary spleens (HP:0009799)2.48032852
40Rhabdomyosarcoma (HP:0002859)2.44167499
41Sloping forehead (HP:0000340)2.43626563
42Oral leukoplakia (HP:0002745)2.40092660
43Subacute progressive viral hepatitis (HP:0006572)2.39899798
44Abnormal lung lobation (HP:0002101)2.36448985
45Abnormality of B cell number (HP:0010975)2.35537672
4611 pairs of ribs (HP:0000878)2.35126462
47Glioma (HP:0009733)2.31281603
48Abnormality of the astrocytes (HP:0100707)2.31143827
49Astrocytoma (HP:0009592)2.31143827
50Cerebral hypomyelination (HP:0006808)2.31004316
51Progressive microcephaly (HP:0000253)2.30917252
52Atresia of the external auditory canal (HP:0000413)2.30414183
53Volvulus (HP:0002580)2.29253498
54Abnormality of DNA repair (HP:0003254)2.28443035
55Bone marrow hypocellularity (HP:0005528)2.28008279
56Abnormality of the duodenum (HP:0002246)2.27856185
57Triphalangeal thumb (HP:0001199)2.27226965
58Nephroblastoma (Wilms tumor) (HP:0002667)2.27095220
59Increased nuchal translucency (HP:0010880)2.26762182
60Deviation of the thumb (HP:0009603)2.26427721
61Proximal placement of thumb (HP:0009623)2.26265373
62Hypoplasia of the pons (HP:0012110)2.24619103
63Autoimmune hemolytic anemia (HP:0001890)2.23233407
64Hypoplasia of the capital femoral epiphysis (HP:0003090)2.22874344
65Submucous cleft hard palate (HP:0000176)2.19683082
66Abnormality of the fingertips (HP:0001211)2.19479182
67Neoplasm of the pancreas (HP:0002894)2.18989514
68Depressed nasal tip (HP:0000437)2.18548046
69Aplasia/Hypoplasia involving the musculature (HP:0001460)2.17774541
70Abnormality of the carotid arteries (HP:0005344)2.17629336
71Duplicated collecting system (HP:0000081)2.17019037
72Sandal gap (HP:0001852)2.16741524
73Horseshoe kidney (HP:0000085)2.15387991
74Tracheoesophageal fistula (HP:0002575)2.14650078
75Acute lymphatic leukemia (HP:0006721)2.13541713
76Embryonal renal neoplasm (HP:0011794)2.12871357
77Deep philtrum (HP:0002002)2.12824620
78Basal cell carcinoma (HP:0002671)2.12069160
79Short thumb (HP:0009778)2.09624580
80Micronodular cirrhosis (HP:0001413)2.09102294
81Prominent nose (HP:0000448)2.08886611
82Prostate neoplasm (HP:0100787)2.07980242
83Premature graying of hair (HP:0002216)2.07819252
84Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.07728040
85Neoplasm of the oral cavity (HP:0100649)2.06875368
86Microvesicular hepatic steatosis (HP:0001414)2.05984119
87Cafe-au-lait spot (HP:0000957)2.04889584
88Abnormality of abdominal situs (HP:0011620)2.04780417
89Abdominal situs inversus (HP:0003363)2.04780417
90Trismus (HP:0000211)2.04334213
91Facial hemangioma (HP:0000329)2.00833302
92Clubbing of toes (HP:0100760)2.00281263
93Neoplasm of striated muscle (HP:0009728)1.99551050
94B lymphocytopenia (HP:0010976)1.97143816
95Viral hepatitis (HP:0006562)1.96237696
96Amaurosis fugax (HP:0100576)1.95248113
97T lymphocytopenia (HP:0005403)1.95094166
98Stomatitis (HP:0010280)1.94606559
99Melanoma (HP:0002861)1.94466713
100Deep palmar crease (HP:0006191)1.91295922
101Abnormality of T cell number (HP:0011839)1.90627084
102Cellular immunodeficiency (HP:0005374)1.90429934
103Optic nerve coloboma (HP:0000588)1.90396521
104Breast carcinoma (HP:0003002)1.90393608
105Macrocytic anemia (HP:0001972)1.89834747
106Neoplasm of the tracheobronchial system (HP:0100552)1.89349184
107Missing ribs (HP:0000921)1.88766836
108Limb hypertonia (HP:0002509)1.87656259
109Abnormality of the renal collecting system (HP:0004742)1.87220824
110Cerebellar dysplasia (HP:0007033)1.86791082
111Type II lissencephaly (HP:0007260)1.84759343
112Poor head control (HP:0002421)1.84664772
113Overlapping toe (HP:0001845)1.84165708
114Preauricular skin tag (HP:0000384)1.83880357
115Abnormality of cells of the erythroid lineage (HP:0012130)1.83550569
116Spinal muscular atrophy (HP:0007269)1.83316623
117Aplasia/Hypoplasia of the sternum (HP:0006714)1.82638560
118Granulocytopenia (HP:0001913)1.82376834
119Squamous cell carcinoma (HP:0002860)1.82221186
120Abnormal trabecular bone morphology (HP:0100671)1.82184276
121Neoplasm of the adrenal gland (HP:0100631)1.81731085
122Pallor (HP:0000980)1.81225628
123Optic neuritis (HP:0100653)1.79780049
124Retrobulbar optic neuritis (HP:0100654)1.79780049
125IgA deficiency (HP:0002720)1.79372529
126Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.78629325
127Absent epiphyses (HP:0010577)1.78629325
128Cortical dysplasia (HP:0002539)1.77746326
129Arteriovenous malformation (HP:0100026)1.77343092
130Recurrent viral infections (HP:0004429)1.77220450
131Atrophy/Degeneration involving motor neurons (HP:0007373)1.76590205
132Progressive inability to walk (HP:0002505)1.76338977
133Breast aplasia (HP:0100783)1.76210227
134Neoplasm of the respiratory system (HP:0100606)1.76093373
135Combined immunodeficiency (HP:0005387)1.76046731
136Abnormal number of erythroid precursors (HP:0012131)1.74890711
137Skin tags (HP:0010609)1.73835721
138Neoplasm of the colon (HP:0100273)1.73827037
139Sparse lateral eyebrow (HP:0005338)1.73266775
140Lymphoma (HP:0002665)1.72732453
141Long eyelashes (HP:0000527)1.72573792
142Slender long bone (HP:0003100)1.72441087
143Long foot (HP:0001833)1.72194638
144Neuroectodermal neoplasm (HP:0030061)1.71322685
145Neuroepithelial neoplasm (HP:0030063)1.71322685
146Nervous tissue neoplasm (HP:0030060)1.71322685
147Eosinophilia (HP:0001880)1.71154729
148Premature ovarian failure (HP:0008209)1.70217067
149Anal stenosis (HP:0002025)1.70081049
150Alveolar cell carcinoma (HP:0006519)1.69347142
151Intestinal atresia (HP:0011100)1.69336639
152Protruding tongue (HP:0010808)1.68806202
153Aplasia/Hypoplasia of the earlobes (HP:0009906)1.68355653
154Meningioma (HP:0002858)1.68283918
155Abnormality of T cell physiology (HP:0011840)1.67360663
156Diastasis recti (HP:0001540)1.65703068
157Abnormality of T cells (HP:0002843)1.64535339

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.41768379
2MKNK24.01263594
3BUB13.96379477
4WEE13.88235750
5MKNK13.32513440
6PASK3.06673748
7IRAK43.04758174
8SRPK12.97060954
9CDK122.93667852
10TSSK62.86398912
11EIF2AK12.73082749
12TAF12.70719226
13NEK22.58144697
14TTK2.35649331
15MAP3K142.18513155
16PLK42.10529827
17PLK12.01571457
18CDK71.93576511
19ATR1.90429582
20ACVR1B1.87891786
21NEK11.77313710
22BRD41.67829783
23PLK31.67075872
24IRAK31.62905218
25FRK1.61983021
26TESK21.60804567
27AURKB1.58979838
28RPS6KB21.55663582
29TRIM281.54409996
30NME11.52110948
31VRK11.50787140
32TLK11.49118391
33BRSK21.48225744
34* CHEK11.41183559
35STK101.36133746
36EPHA21.35017480
37NUAK11.34327445
38EIF2AK31.33819873
39CHEK21.33734577
40IKBKE1.29786112
41DYRK31.27376919
42CAMK1D1.26242237
43BMPR1B1.24651712
44PAK41.17164081
45IKBKB1.16769403
46STK41.16294673
47CDK41.16007327
48ZAK1.14311638
49ATM1.12256483
50STK161.09752325
51RPS6KA41.08051160
52AURKA1.06484896
53MAP3K81.05497856
54ERBB31.05354912
55BRSK11.01433961
56* CDK21.00312781
57NEK60.93434065
58PBK0.93254822
59MAP4K10.90421894
60TAOK30.90206375
61EEF2K0.87817416
62CCNB10.87555348
63VRK20.85154801
64CAMK1G0.84622092
65TGFBR10.83635780
66ALK0.82892127
67SMG10.80544699
68CDK80.80063197
69MAP3K100.79935716
70CDK10.78811196
71CSNK2A20.77893279
72MAP2K30.77728017
73MST1R0.76246616
74FLT30.75832100
75EIF2AK20.73530046
76PKN20.72525232
77MELK0.71308940
78PIM10.69281527
79NME20.68605757
80TEC0.68035445
81* CSNK2A10.67855913
82MST40.67541824
83KSR10.66338724
84MAPKAPK30.65865759
85YES10.63587672
86IRAK10.62203562
87PNCK0.56712345
88CAMKK20.55247679
89TYK20.53118069
90AKT30.53113579
91STK38L0.53021903
92HIPK20.52830245
93PAK10.52339638
94STK30.52102949
95WNK30.51375749
96CDK60.50073418
97PRKCI0.49914514
98SIK20.49817343
99MTOR0.49447866
100SCYL20.49257748
101CSNK1E0.49128624
102PRKDC0.48824485
103CLK10.46645005
104CSF1R0.45709634
105KDR0.44907079
106BMPR20.42534794
107MAPK140.40412434
108NEK90.39361750
109MAP2K60.38843855
110BTK0.38604272
111MET0.38209150
112PIM20.38208917
113FGR0.37911286
114FGFR10.37210468
115TESK10.36107698
116TNIK0.35497572
117MAPK130.34453600
118TNK20.34175028
119CSNK1D0.34088388
120JAK10.34043640
121CDK90.34017405
122AKT20.33920190
123ADRBK20.33567281
124TXK0.33366715
125PLK20.31595960
126GSK3B0.30224917
127AKT10.28550022
128PAK20.26977517
129LATS10.26765940
130MARK30.25949348
131ZAP700.24981317
132MAPK110.24969703
133MAPK10.23897106
134SIK30.21818151
135LATS20.20012714
136LYN0.19496755
137MAPKAPK20.18008533
138CHUK0.17819309
139RPS6KB10.17597471
140TAOK20.17366632

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.72087698
2Mismatch repair_Homo sapiens_hsa034304.38181660
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.89179481
4* Spliceosome_Homo sapiens_hsa030403.51402775
5RNA transport_Homo sapiens_hsa030133.36778320
6Homologous recombination_Homo sapiens_hsa034403.08167791
7Base excision repair_Homo sapiens_hsa034102.96696508
8One carbon pool by folate_Homo sapiens_hsa006702.83854163
9Proteasome_Homo sapiens_hsa030502.81643281
10Cell cycle_Homo sapiens_hsa041102.80396321
11RNA polymerase_Homo sapiens_hsa030202.80139273
12Nucleotide excision repair_Homo sapiens_hsa034202.75532845
13Ribosome_Homo sapiens_hsa030102.58009927
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.56634593
15Fanconi anemia pathway_Homo sapiens_hsa034602.48389017
16Non-homologous end-joining_Homo sapiens_hsa034502.20307035
17RNA degradation_Homo sapiens_hsa030182.16057646
18mRNA surveillance pathway_Homo sapiens_hsa030152.10045498
19Pyrimidine metabolism_Homo sapiens_hsa002402.08889098
20Basal transcription factors_Homo sapiens_hsa030222.05878262
21p53 signaling pathway_Homo sapiens_hsa041151.69070892
22Epstein-Barr virus infection_Homo sapiens_hsa051691.34393657
23TNF signaling pathway_Homo sapiens_hsa046681.27744603
24Herpes simplex infection_Homo sapiens_hsa051681.21736426
25Toll-like receptor signaling pathway_Homo sapiens_hsa046201.20694386
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.18090769
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.13936402
28Non-small cell lung cancer_Homo sapiens_hsa052231.13129051
29Purine metabolism_Homo sapiens_hsa002301.07478086
30Jak-STAT signaling pathway_Homo sapiens_hsa046301.02684330
31Osteoclast differentiation_Homo sapiens_hsa043801.00738122
32Viral carcinogenesis_Homo sapiens_hsa052030.98041104
33Antigen processing and presentation_Homo sapiens_hsa046120.97744791
34Hepatitis C_Homo sapiens_hsa051600.95404747
35Oocyte meiosis_Homo sapiens_hsa041140.90004866
36HTLV-I infection_Homo sapiens_hsa051660.87430657
37Systemic lupus erythematosus_Homo sapiens_hsa053220.86616766
38MicroRNAs in cancer_Homo sapiens_hsa052060.85451730
39B cell receptor signaling pathway_Homo sapiens_hsa046620.85375309
40Toxoplasmosis_Homo sapiens_hsa051450.85336870
41Legionellosis_Homo sapiens_hsa051340.85144974
42Regulation of autophagy_Homo sapiens_hsa041400.84851610
43Cyanoamino acid metabolism_Homo sapiens_hsa004600.80027487
44FoxO signaling pathway_Homo sapiens_hsa040680.78463453
45Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.76738694
46Biosynthesis of amino acids_Homo sapiens_hsa012300.71964181
47Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.70975452
48Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70665216
49Primary immunodeficiency_Homo sapiens_hsa053400.70298439
50Glioma_Homo sapiens_hsa052140.68853574
51Cysteine and methionine metabolism_Homo sapiens_hsa002700.68062621
52Tuberculosis_Homo sapiens_hsa051520.67092989
53Small cell lung cancer_Homo sapiens_hsa052220.65341227
54TGF-beta signaling pathway_Homo sapiens_hsa043500.65247907
55Asthma_Homo sapiens_hsa053100.65173377
56Pentose phosphate pathway_Homo sapiens_hsa000300.63217706
57Basal cell carcinoma_Homo sapiens_hsa052170.62751056
58Thyroid cancer_Homo sapiens_hsa052160.61189785
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60859617
60Measles_Homo sapiens_hsa051620.60537362
61Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.57753229
62Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.57298039
63Selenocompound metabolism_Homo sapiens_hsa004500.57277635
64Pancreatic cancer_Homo sapiens_hsa052120.57166306
65Hippo signaling pathway_Homo sapiens_hsa043900.57036680
66Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56656379
67Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56006225
68Notch signaling pathway_Homo sapiens_hsa043300.55329317
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54047613
70Colorectal cancer_Homo sapiens_hsa052100.53741026
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53569479
72HIF-1 signaling pathway_Homo sapiens_hsa040660.52509807
73Prolactin signaling pathway_Homo sapiens_hsa049170.51447283
74NF-kappa B signaling pathway_Homo sapiens_hsa040640.50819246
75Endometrial cancer_Homo sapiens_hsa052130.50099405
76Hepatitis B_Homo sapiens_hsa051610.50017420
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49224490
78Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48580875
79Apoptosis_Homo sapiens_hsa042100.47263732
80ABC transporters_Homo sapiens_hsa020100.46694609
81Viral myocarditis_Homo sapiens_hsa054160.44643506
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44586271
83African trypanosomiasis_Homo sapiens_hsa051430.44125042
84Dorso-ventral axis formation_Homo sapiens_hsa043200.43851948
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42551827
86Influenza A_Homo sapiens_hsa051640.41542908
87Adherens junction_Homo sapiens_hsa045200.38707491
88Renal cell carcinoma_Homo sapiens_hsa052110.37765096
89Protein export_Homo sapiens_hsa030600.37549419
90NOD-like receptor signaling pathway_Homo sapiens_hsa046210.37494665
91Vitamin B6 metabolism_Homo sapiens_hsa007500.36765221
92Shigellosis_Homo sapiens_hsa051310.36298251
93Hematopoietic cell lineage_Homo sapiens_hsa046400.35877929
94Steroid biosynthesis_Homo sapiens_hsa001000.34986440
95Pathways in cancer_Homo sapiens_hsa052000.34632596
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.34401292
97Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.34363574
98Pertussis_Homo sapiens_hsa051330.33857237
99Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.33816793
100Folate biosynthesis_Homo sapiens_hsa007900.33625868
101Lysine degradation_Homo sapiens_hsa003100.33115868
102Malaria_Homo sapiens_hsa051440.32637304
103Renin-angiotensin system_Homo sapiens_hsa046140.32372658
104Rheumatoid arthritis_Homo sapiens_hsa053230.32315605
105Chronic myeloid leukemia_Homo sapiens_hsa052200.30581577
106RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.30315636
107Hedgehog signaling pathway_Homo sapiens_hsa043400.29645751
108Prostate cancer_Homo sapiens_hsa052150.29516163
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.29281302
110Acute myeloid leukemia_Homo sapiens_hsa052210.28160048
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.28072431
112Melanoma_Homo sapiens_hsa052180.27825436
113Wnt signaling pathway_Homo sapiens_hsa043100.27493096
114Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.26116869
115mTOR signaling pathway_Homo sapiens_hsa041500.26109310
116Bladder cancer_Homo sapiens_hsa052190.25204761
117Huntingtons disease_Homo sapiens_hsa050160.24047112
118Fructose and mannose metabolism_Homo sapiens_hsa000510.23973265
119Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.23621659
120Autoimmune thyroid disease_Homo sapiens_hsa053200.23221898
121Type I diabetes mellitus_Homo sapiens_hsa049400.22645206
122Allograft rejection_Homo sapiens_hsa053300.20135445
123Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.19939702
124Carbon metabolism_Homo sapiens_hsa012000.19439510
1252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.18546309
126Intestinal immune network for IgA production_Homo sapiens_hsa046720.17825489
127T cell receptor signaling pathway_Homo sapiens_hsa046600.17120519
128Sulfur relay system_Homo sapiens_hsa041220.15564308
129Alcoholism_Homo sapiens_hsa050340.15359119
130PI3K-Akt signaling pathway_Homo sapiens_hsa041510.14322033
131Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.14076896
132Leishmaniasis_Homo sapiens_hsa051400.12704860
133Thyroid hormone signaling pathway_Homo sapiens_hsa049190.11543678
134Graft-versus-host disease_Homo sapiens_hsa053320.11512711
135Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.11362111

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