PRPF31

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a component of the spliceosome complex and is one of several retinitis pigmentosa-causing genes. When the gene product is added to the spliceosome complex, activation occurs. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.02735262
2DNA strand elongation involved in DNA replication (GO:0006271)4.94475046
3DNA strand elongation (GO:0022616)4.74507324
4ribosomal small subunit assembly (GO:0000028)4.72970443
5DNA replication initiation (GO:0006270)4.65894531
6telomere maintenance via semi-conservative replication (GO:0032201)4.52576694
7formation of translation preinitiation complex (GO:0001731)4.43774112
8protein localization to kinetochore (GO:0034501)4.38331952
9nucleobase biosynthetic process (GO:0046112)4.36883847
10maturation of SSU-rRNA (GO:0030490)4.25532560
11IMP biosynthetic process (GO:0006188)4.24781079
12viral transcription (GO:0019083)4.22519386
13ribosomal large subunit biogenesis (GO:0042273)4.18307501
14translational termination (GO:0006415)4.16506738
15regulation of mitochondrial translation (GO:0070129)4.12794045
16protein maturation by protein folding (GO:0022417)4.08931207
17ribosomal small subunit biogenesis (GO:0042274)4.04787107
18telomere maintenance via recombination (GO:0000722)4.03964232
19peptidyl-arginine omega-N-methylation (GO:0035247)3.96390101
20ribonucleoprotein complex biogenesis (GO:0022613)3.95214520
21pentose-phosphate shunt (GO:0006098)3.95097213
22purine nucleobase biosynthetic process (GO:0009113)3.92930369
23DNA replication checkpoint (GO:0000076)3.89919650
24ribosome biogenesis (GO:0042254)3.86190354
25mitotic recombination (GO:0006312)3.83144504
26IMP metabolic process (GO:0046040)3.83138469
27translational initiation (GO:0006413)3.81054945
28translational elongation (GO:0006414)3.80989415
29* spliceosomal snRNP assembly (GO:0000387)3.70848422
30pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.70363525
31DNA replication-dependent nucleosome assembly (GO:0006335)3.68945555
32DNA replication-dependent nucleosome organization (GO:0034723)3.68945555
33NADPH regeneration (GO:0006740)3.65781491
34mitotic nuclear envelope disassembly (GO:0007077)3.64760850
35telomere maintenance via telomere lengthening (GO:0010833)3.64644729
36DNA deamination (GO:0045006)3.63847886
37establishment of integrated proviral latency (GO:0075713)3.63147546
38COPI coating of Golgi vesicle (GO:0048205)3.61065512
39Golgi transport vesicle coating (GO:0048200)3.61065512
40proteasome assembly (GO:0043248)3.59113947
41rRNA processing (GO:0006364)3.58815525
42protein localization to chromosome, centromeric region (GO:0071459)3.58292136
43SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.57904446
44negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.56495395
45nucleotide-excision repair, DNA gap filling (GO:0006297)3.54759270
46mitotic metaphase plate congression (GO:0007080)3.52670408
47cotranslational protein targeting to membrane (GO:0006613)3.52080387
48ribosome assembly (GO:0042255)3.52028217
49nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.51860222
50proline biosynthetic process (GO:0006561)3.49465421
51protein targeting to ER (GO:0045047)3.48872390
52GDP-mannose metabolic process (GO:0019673)3.47754094
53establishment of viral latency (GO:0019043)3.47554705
54CENP-A containing nucleosome assembly (GO:0034080)3.47031581
55nucleobase-containing small molecule interconversion (GO:0015949)3.46869124
56folic acid-containing compound biosynthetic process (GO:0009396)3.46772944
57rRNA metabolic process (GO:0016072)3.44600703
58negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.43089937
59viral mRNA export from host cell nucleus (GO:0046784)3.42673630
60rRNA transcription (GO:0009303)3.42662250
61pentose metabolic process (GO:0019321)3.42159249
62cellular protein complex disassembly (GO:0043624)3.40847694
63pseudouridine synthesis (GO:0001522)3.40140463
64chromatin remodeling at centromere (GO:0031055)3.38434396
65histone arginine methylation (GO:0034969)3.37516803
66regulation of translational fidelity (GO:0006450)3.36181266
67glucose catabolic process (GO:0006007)3.36076642
68maturation of 5.8S rRNA (GO:0000460)3.35210553
69membrane disassembly (GO:0030397)3.33987862
70nuclear envelope disassembly (GO:0051081)3.33987862
71anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.32283009
72negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.31222145
73viral life cycle (GO:0019058)3.30147792
74establishment of protein localization to endoplasmic reticulum (GO:0072599)3.30081110
75protein localization to endoplasmic reticulum (GO:0070972)3.29614535
76nuclear pore organization (GO:0006999)3.29012750
77guanosine-containing compound biosynthetic process (GO:1901070)3.28714377
78transcription-coupled nucleotide-excision repair (GO:0006283)3.28697161
79positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.26544342
80regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.25586856
81nuclear envelope reassembly (GO:0031468)3.25276192
82mitotic nuclear envelope reassembly (GO:0007084)3.25276192
83tRNA methylation (GO:0030488)3.24588167
84pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.24451236
85regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.22077436
86DNA replication-independent nucleosome assembly (GO:0006336)3.19031340
87DNA replication-independent nucleosome organization (GO:0034724)3.19031340
88translation (GO:0006412)3.18522934
89negative regulation of ligase activity (GO:0051352)3.18514615
90negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.18514615
91pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.17140578
92spliceosomal complex assembly (GO:0000245)3.15874104
93base-excision repair (GO:0006284)3.15312603
94kinetochore organization (GO:0051383)3.15289952
95cellular component biogenesis (GO:0044085)3.13940162
96peptidyl-arginine methylation (GO:0018216)3.13131616
97peptidyl-arginine N-methylation (GO:0035246)3.13131616
98nuclear pore complex assembly (GO:0051292)3.12656637
99mitotic chromosome condensation (GO:0007076)3.12609382
100protein complex disassembly (GO:0043241)3.11700186
101base-excision repair, AP site formation (GO:0006285)3.11360336
102regulation of translational termination (GO:0006449)3.10966674
103transcription elongation from RNA polymerase III promoter (GO:0006385)3.09769481
104termination of RNA polymerase III transcription (GO:0006386)3.09769481
105pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.09010453
106attachment of spindle microtubules to kinetochore (GO:0008608)3.08570469
107cell cycle G1/S phase transition (GO:0044843)3.06760378
108G1/S transition of mitotic cell cycle (GO:0000082)3.06760378
109somatic diversification of immune receptors via somatic mutation (GO:0002566)3.06291057
110somatic hypermutation of immunoglobulin genes (GO:0016446)3.06291057
111mitotic sister chromatid segregation (GO:0000070)3.04723711
112UTP biosynthetic process (GO:0006228)3.04035367
113regulation of cellular amino acid metabolic process (GO:0006521)3.03744650
114DNA duplex unwinding (GO:0032508)3.03594871
115metaphase plate congression (GO:0051310)3.03594655
1167-methylguanosine mRNA capping (GO:0006370)3.03552760
117pyrimidine nucleotide catabolic process (GO:0006244)3.03087050
118DNA geometric change (GO:0032392)3.02563951
1197-methylguanosine RNA capping (GO:0009452)3.02417497
120RNA capping (GO:0036260)3.02417497
121DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.02186988
122CTP metabolic process (GO:0046036)3.02153674
123CTP biosynthetic process (GO:0006241)3.02153674
124* mRNA splicing, via spliceosome (GO:0000398)3.00341166
125* RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.00341166
126transcription elongation from RNA polymerase I promoter (GO:0006362)2.99870172
127cullin deneddylation (GO:0010388)2.99447902
128* RNA splicing, via transesterification reactions (GO:0000375)2.99309632
129rRNA modification (GO:0000154)2.98586825
130pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.98566391
131signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.97961724
132intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.97961724
133macromolecular complex disassembly (GO:0032984)2.95902706
134signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.95604446
135signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.95604446
136signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.95604446
137signal transduction involved in DNA damage checkpoint (GO:0072422)2.94430180
138signal transduction involved in DNA integrity checkpoint (GO:0072401)2.94430180
139deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.93768531
140termination of RNA polymerase I transcription (GO:0006363)2.93748543
141negative regulation of mRNA processing (GO:0050686)2.92447669
142pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.91096981
143protein retention in ER lumen (GO:0006621)2.90821954
144protein targeting to mitochondrion (GO:0006626)2.88239700
145transcription from mitochondrial promoter (GO:0006390)2.85532600
146UV protection (GO:0009650)2.83752671
147maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.81767895
148GTP biosynthetic process (GO:0006183)2.81711818
149protein complex localization (GO:0031503)2.81029836
150positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.80180582
151tRNA aminoacylation for protein translation (GO:0006418)2.78728737
152GMP metabolic process (GO:0046037)2.74458545
153signal transduction involved in cell cycle checkpoint (GO:0072395)2.74341134
154negative regulation of mRNA metabolic process (GO:1903312)2.72940247
155iron-sulfur cluster assembly (GO:0016226)2.72671394
156metallo-sulfur cluster assembly (GO:0031163)2.72671394
157regulation of mammary gland epithelial cell proliferation (GO:0033599)2.72641345
158protein deneddylation (GO:0000338)2.71396199
159negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.70043306
160UTP metabolic process (GO:0046051)2.69626571
161peptidyl-histidine modification (GO:0018202)2.68453463

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.44956269
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.54622901
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.04174603
4* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.64096409
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.55469645
6* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.40874158
7* EST1_17652178_ChIP-ChIP_JURKAT_Human3.40703148
8* GABP_17652178_ChIP-ChIP_JURKAT_Human3.21720959
9* ETS1_20019798_ChIP-Seq_JURKAT_Human3.10944687
10* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.10481494
11MYC_19079543_ChIP-ChIP_MESCs_Mouse3.06341684
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.99555046
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.94082061
14* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.83936607
15* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.83578239
16* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.82608871
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.79958107
18* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.45265219
19* XRN2_22483619_ChIP-Seq_HELA_Human2.43636028
20VDR_23849224_ChIP-Seq_CD4+_Human2.41668694
21SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.37905384
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.36546950
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.36462387
24FOXP3_21729870_ChIP-Seq_TREG_Human2.18921929
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.12193847
26THAP11_20581084_ChIP-Seq_MESCs_Mouse2.10627424
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.08771147
28DCP1A_22483619_ChIP-Seq_HELA_Human2.08166984
29* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.05198612
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.00326627
31TTF2_22483619_ChIP-Seq_HELA_Human1.96442233
32GABP_19822575_ChIP-Seq_HepG2_Human1.93241655
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.91988957
34ELK1_19687146_ChIP-ChIP_HELA_Human1.90959892
35* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.87475664
36E2F1_21310950_ChIP-Seq_MCF-7_Human1.85755504
37TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84869065
38CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.81128364
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81043715
40AR_21909140_ChIP-Seq_LNCAP_Human1.80457196
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.79833744
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.78852891
43* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.78686339
44PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.76966439
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.73406260
46TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.69511317
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.68080321
48NANOG_18555785_ChIP-Seq_MESCs_Mouse1.67208744
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.66191469
50CIITA_25753668_ChIP-Seq_RAJI_Human1.63358741
51FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.62301286
52SRF_21415370_ChIP-Seq_HL-1_Mouse1.57988493
53MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.57299294
54KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.50364745
55ZNF263_19887448_ChIP-Seq_K562_Human1.49039907
56ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47698581
57* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.45409559
58* ELK3_25401928_ChIP-Seq_HUVEC_Human1.45292900
59EGR1_19374776_ChIP-ChIP_THP-1_Human1.45249770
60LXR_22292898_ChIP-Seq_THP-1_Human1.40627862
61SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.37985196
62MYC_22102868_ChIP-Seq_BL_Human1.37705333
63KDM5A_27292631_Chip-Seq_BREAST_Human1.37651844
64* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.37242783
65TET1_21451524_ChIP-Seq_MESCs_Mouse1.35863827
66PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.35319301
67NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.34297491
68ERG_20887958_ChIP-Seq_HPC-7_Mouse1.32620222
69* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.31782716
70RARG_19884340_ChIP-ChIP_MEFs_Mouse1.29276337
71POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.28363761
72POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.24156824
73SRY_22984422_ChIP-ChIP_TESTIS_Rat1.22826783
74CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.22341108
75CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.19993601
76ELF1_20517297_ChIP-Seq_JURKAT_Human1.19189168
77P68_20966046_ChIP-Seq_HELA_Human1.18150678
78* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17870548
79PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17791739
80SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.16787047
81CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.15050890
82E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14001722
83TFEB_21752829_ChIP-Seq_HELA_Human1.12850578
84NOTCH1_21737748_ChIP-Seq_TLL_Human1.12075979
85KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.11311438
86KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.10738123
87RACK7_27058665_Chip-Seq_MCF-7_Human1.10436042
88STAT3_1855785_ChIP-Seq_MESCs_Mouse1.10230990
89ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09173833
90ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.08838471
91MYC_18940864_ChIP-ChIP_HL60_Human1.08122176
92SPI1_23547873_ChIP-Seq_NB4_Human1.07424212
93SOX2_18555785_ChIP-Seq_MESCs_Mouse1.07142305
94* FOXP1_21924763_ChIP-Seq_HESCs_Human1.04314435
95VDR_21846776_ChIP-Seq_THP-1_Human1.03500419
96TBX5_21415370_ChIP-Seq_HL-1_Mouse1.02996316
97ELK1_22589737_ChIP-Seq_MCF10A_Human1.02721085
98CTCF_18555785_ChIP-Seq_MESCs_Mouse1.02019439
99* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.00576230
100SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.00482326
101TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00117442
102ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.99985188
103TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99415499
104* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.99021256
105MAF_26560356_Chip-Seq_TH2_Human0.98973173
106CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97996203
107BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96724211
108KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96028938
109CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.92702418
110DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.92433528
111RBPJ_22232070_ChIP-Seq_NCS_Mouse0.89454528
112HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.87623236
113IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.87330846
114TP63_19390658_ChIP-ChIP_HaCaT_Human0.85523128
115IRF8_21731497_ChIP-ChIP_J774_Mouse0.85074421
116DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.83108850
117* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.82075726
118* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79735465
119* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.79652599
120KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.78056701
121* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.77574837
122HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.77020234
123SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.76890814
124TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.75333583
125OCT4_18692474_ChIP-Seq_MEFs_Mouse0.74295428

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.43911419
2MP0010094_abnormal_chromosome_stability4.80791598
3MP0004957_abnormal_blastocyst_morpholog4.53268937
4MP0003111_abnormal_nucleus_morphology4.47513747
5MP0008057_abnormal_DNA_replication4.27404254
6MP0003077_abnormal_cell_cycle4.08495187
7MP0008058_abnormal_DNA_repair3.71988325
8MP0005451_abnormal_body_composition3.22605127
9MP0008932_abnormal_embryonic_tissue2.94590099
10MP0002396_abnormal_hematopoietic_system2.90291233
11MP0009278_abnormal_bone_marrow2.72495860
12MP0002877_abnormal_melanocyte_morpholog2.69557563
13MP0008007_abnormal_cellular_replicative2.61667376
14MP0008260_abnormal_autophagy2.60829390
15MP0005058_abnormal_lysosome_morphology2.46211563
16MP0003123_paternal_imprinting2.43335372
17MP0001730_embryonic_growth_arrest2.42030917
18MP0000350_abnormal_cell_proliferation2.21533188
19MP0003786_premature_aging1.99089872
20MP0000490_abnormal_crypts_of1.82283347
21MP0004185_abnormal_adipocyte_glucose1.79927125
22MP0010307_abnormal_tumor_latency1.79564150
23MP0008877_abnormal_DNA_methylation1.77208351
24MP0009840_abnormal_foam_cell1.73506476
25MP0009333_abnormal_splenocyte_physiolog1.72273265
26MP0004808_abnormal_hematopoietic_stem1.67696200
27MP0001697_abnormal_embryo_size1.66377073
28MP0003191_abnormal_cellular_cholesterol1.65092984
29MP0001849_ear_inflammation1.60542526
30MP0005501_abnormal_skin_physiology1.58157019
31MP0000313_abnormal_cell_death1.56030355
32* MP0002080_prenatal_lethality1.55830094
33MP0002019_abnormal_tumor_incidence1.47242238
34MP0009697_abnormal_copulation1.46972227
35MP0001661_extended_life_span1.46701182
36MP0002398_abnormal_bone_marrow1.45225234
37MP0003121_genomic_imprinting1.44165657
38MP0001672_abnormal_embryogenesis/_devel1.43833665
39MP0005380_embryogenesis_phenotype1.43833665
40MP0001835_abnormal_antigen_presentation1.40877213
41MP0000703_abnormal_thymus_morphology1.40363847
42MP0003763_abnormal_thymus_physiology1.38227980
43MP0002085_abnormal_embryonic_tissue1.37419099
44MP0010352_gastrointestinal_tract_polyps1.36265299
45MP0002722_abnormal_immune_system1.34947524
46MP0000689_abnormal_spleen_morphology1.31042454
47MP0005397_hematopoietic_system_phenotyp1.28851877
48MP0001545_abnormal_hematopoietic_system1.28851877
49MP0003984_embryonic_growth_retardation1.28819759
50MP0003718_maternal_effect1.28631493
51MP0000751_myopathy1.28518550
52MP0002088_abnormal_embryonic_growth/wei1.24052746
53MP0002084_abnormal_developmental_patter1.22423336
54MP0006292_abnormal_olfactory_placode1.19685275
55MP0000372_irregular_coat_pigmentation1.18962450
56MP0005330_cardiomyopathy1.18310628
57MP0000678_abnormal_parathyroid_gland1.17004484
58MP0002429_abnormal_blood_cell1.13291480
59MP0003567_abnormal_fetal_cardiomyocyte1.11964510
60MP0002796_impaired_skin_barrier1.11744449
61MP0004197_abnormal_fetal_growth/weight/1.10258990
62MP0001853_heart_inflammation1.10055449
63MP0009379_abnormal_foot_pigmentation1.09868804
64MP0000749_muscle_degeneration1.08974945
65MP0000358_abnormal_cell_content/1.08863207
66MP0002086_abnormal_extraembryonic_tissu1.07182396
67MP0000747_muscle_weakness1.06325609
68MP0003221_abnormal_cardiomyocyte_apopto1.04202063
69MP0003186_abnormal_redox_activity1.04172010
70MP0000716_abnormal_immune_system1.01144097
71MP0009672_abnormal_birth_weight0.98534207
72MP0001800_abnormal_humoral_immune0.97526017
73MP0000858_altered_metastatic_potential0.96585022
74MP0005670_abnormal_white_adipose0.96204195
75MP0001529_abnormal_vocalization0.95697023
76MP0002269_muscular_atrophy0.94694914
77MP0005171_absent_coat_pigmentation0.94301850
78MP0002420_abnormal_adaptive_immunity0.93426951
79MP0001293_anophthalmia0.93091938
80MP0002210_abnormal_sex_determination0.92321112
81MP0000750_abnormal_muscle_regeneration0.92177898
82MP0004133_heterotaxia0.91492173
83MP0001819_abnormal_immune_cell0.91288192
84MP0002452_abnormal_antigen_presenting0.90630495
85MP0000681_abnormal_thyroid_gland0.89456065
86MP0003890_abnormal_embryonic-extraembry0.87978781
87MP0005384_cellular_phenotype0.87897960
88MP0004858_abnormal_nervous_system0.86400976
89MP0002095_abnormal_skin_pigmentation0.86240763
90MP0003806_abnormal_nucleotide_metabolis0.85841064
91MP0001764_abnormal_homeostasis0.85822840
92MP0006054_spinal_hemorrhage0.85668444
93MP0001881_abnormal_mammary_gland0.85108768
94MP0002132_abnormal_respiratory_system0.84588965
95MP0006035_abnormal_mitochondrial_morpho0.84374623
96MP0001145_abnormal_male_reproductive0.84360537
97MP0002653_abnormal_ependyma_morphology0.84298938
98MP0001243_abnormal_dermal_layer0.83782304
99MP0009785_altered_susceptibility_to0.81561809
100MP0000759_abnormal_skeletal_muscle0.81512743
101MP0003315_abnormal_perineum_morphology0.80234171
102MP0002060_abnormal_skin_morphology0.80061205
103MP0001727_abnormal_embryo_implantation0.79861096
104MP0004782_abnormal_surfactant_physiolog0.79441328
105MP0002723_abnormal_immune_serum0.79280179
106MP0001915_intracranial_hemorrhage0.78417512
107MP0001348_abnormal_lacrimal_gland0.78089998
108MP0005666_abnormal_adipose_tissue0.77744569
109MP0005621_abnormal_cell_physiology0.75482500
110MP0002160_abnormal_reproductive_system0.75009007
111MP0005174_abnormal_tail_pigmentation0.74064189
112MP0005025_abnormal_response_to0.73834136
113MP0003705_abnormal_hypodermis_morpholog0.73365226
114MP0002405_respiratory_system_inflammati0.72199275
115MP0004233_abnormal_muscle_weight0.72133871
116MP0006036_abnormal_mitochondrial_physio0.72036371
117MP0005266_abnormal_metabolism0.71816191
118MP0005671_abnormal_response_to0.71559702
119MP0000003_abnormal_adipose_tissue0.71353621
120MP0000343_altered_response_to0.71071889
121MP0005000_abnormal_immune_tolerance0.70857294
122MP0005389_reproductive_system_phenotype0.70684756
123MP0000733_abnormal_muscle_development0.69004634
124MP0005165_increased_susceptibility_to0.68768606
125MP0002970_abnormal_white_adipose0.68174565
126MP0005023_abnormal_wound_healing0.67720659
127MP0001216_abnormal_epidermal_layer0.66651373
128MP0005076_abnormal_cell_differentiation0.66347322
129MP0003566_abnormal_cell_adhesion0.66230858
130MP0001929_abnormal_gametogenesis0.65927992
131MP0002148_abnormal_hypersensitivity_rea0.65352393
132MP0003436_decreased_susceptibility_to0.63528772
133MP0005464_abnormal_platelet_physiology0.63315584
134MP0000653_abnormal_sex_gland0.63027172
135MP0005075_abnormal_melanosome_morpholog0.62677958
136MP0010030_abnormal_orbit_morphology0.59606701
137MP0002938_white_spotting0.58850302
138MP0003448_altered_tumor_morphology0.58219878
139MP0000685_abnormal_immune_system0.57768204
140MP0000015_abnormal_ear_pigmentation0.57749961
141MP0001919_abnormal_reproductive_system0.56875180
142MP0000465_gastrointestinal_hemorrhage0.56764048
143MP0000537_abnormal_urethra_morphology0.54981847
144MP0002111_abnormal_tail_morphology0.52768579
145MP0008789_abnormal_olfactory_epithelium0.52282896

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.11330537
2Microvesicular hepatic steatosis (HP:0001414)4.72842178
3Abnormality of cells of the erythroid lineage (HP:0012130)4.53815431
4Reticulocytopenia (HP:0001896)4.33689262
5Abnormal number of erythroid precursors (HP:0012131)4.33442083
6Ragged-red muscle fibers (HP:0003200)4.10610602
7Breast hypoplasia (HP:0003187)3.72941630
8Agnosia (HP:0010524)3.51754473
9Cerebral hypomyelination (HP:0006808)3.42437511
10Reduced antithrombin III activity (HP:0001976)3.41438174
11Selective tooth agenesis (HP:0001592)3.36296269
12Abnormal gallbladder physiology (HP:0012438)3.31326389
13Cholecystitis (HP:0001082)3.31326389
14Oral leukoplakia (HP:0002745)3.30129073
15Patellar aplasia (HP:0006443)3.27810386
16Aplastic anemia (HP:0001915)3.21159529
17Ependymoma (HP:0002888)3.20920574
18Macrocytic anemia (HP:0001972)3.20299306
19Chromsome breakage (HP:0040012)3.15142050
20Degeneration of anterior horn cells (HP:0002398)3.11471294
21Abnormality of the anterior horn cell (HP:0006802)3.11471294
22Pallor (HP:0000980)3.11448171
23Entropion (HP:0000621)3.10368462
24Aplasia/Hypoplasia of the patella (HP:0006498)3.03851413
25Rough bone trabeculation (HP:0100670)3.00723038
26Colon cancer (HP:0003003)2.98954710
27Chromosomal breakage induced by crosslinking agents (HP:0003221)2.90236489
28Abnormality of the preputium (HP:0100587)2.87810791
29Thrombocytosis (HP:0001894)2.87230997
30Abnormality of chromosome stability (HP:0003220)2.79730720
31Medulloblastoma (HP:0002885)2.77082480
32Meckel diverticulum (HP:0002245)2.76233809
33Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.73008451
34Abnormal protein N-linked glycosylation (HP:0012347)2.73008451
35Abnormal protein glycosylation (HP:0012346)2.73008451
36Abnormal glycosylation (HP:0012345)2.73008451
37Centrally nucleated skeletal muscle fibers (HP:0003687)2.73004406
38Carpal bone hypoplasia (HP:0001498)2.72428510
39Premature graying of hair (HP:0002216)2.70440631
40Myelodysplasia (HP:0002863)2.64794445
41Abnormality of the ileum (HP:0001549)2.63673642
42Aplasia/Hypoplasia of the sacrum (HP:0008517)2.58314929
43Increased serum pyruvate (HP:0003542)2.55574281
44Abnormality of glycolysis (HP:0004366)2.55574281
45Abnormality of the umbilical cord (HP:0010881)2.53485255
46Abnormality of the labia minora (HP:0012880)2.51719908
47Abnormality of the columella (HP:0009929)2.51085478
48Acute necrotizing encephalopathy (HP:0006965)2.47627846
49Bone marrow hypocellularity (HP:0005528)2.45656807
50Abnormality of the distal phalanges of the toes (HP:0010182)2.45469153
51Testicular atrophy (HP:0000029)2.44618492
52Achilles tendon contracture (HP:0001771)2.44593776
53Difficulty climbing stairs (HP:0003551)2.42791400
54Vertebral compression fractures (HP:0002953)2.40877876
55Cutaneous melanoma (HP:0012056)2.39432359
56Rhabdomyolysis (HP:0003201)2.38042566
57Increased serum lactate (HP:0002151)2.37464870
58Mitochondrial inheritance (HP:0001427)2.37426047
59Trismus (HP:0000211)2.36497188
60Hypertensive crisis (HP:0100735)2.35663131
61Absent thumb (HP:0009777)2.35064725
62Increased hepatocellular lipid droplets (HP:0006565)2.35063157
63Increased intramyocellular lipid droplets (HP:0012240)2.35041580
64Aplasia/Hypoplasia of the uvula (HP:0010293)2.34879521
65Increased CSF lactate (HP:0002490)2.34278748
66Abnormal number of incisors (HP:0011064)2.32525662
67Increased muscle lipid content (HP:0009058)2.31789815
68Hepatic necrosis (HP:0002605)2.31171180
69Hypoplasia of the capital femoral epiphysis (HP:0003090)2.30624680
70Cellular immunodeficiency (HP:0005374)2.28329735
71CNS hypomyelination (HP:0003429)2.27759924
72Abnormal mitochondria in muscle tissue (HP:0008316)2.26508091
73Premature rupture of membranes (HP:0001788)2.25213443
74IgM deficiency (HP:0002850)2.24535479
75Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.24348532
76Microretrognathia (HP:0000308)2.24132105
77Pancytopenia (HP:0001876)2.23962022
78Small intestinal stenosis (HP:0012848)2.23509187
79Duodenal stenosis (HP:0100867)2.23509187
80Self-mutilation (HP:0000742)2.22372073
81Neoplasm of the pancreas (HP:0002894)2.21978085
82Hepatocellular necrosis (HP:0001404)2.20689787
83Deviation of the thumb (HP:0009603)2.19926429
84Poikiloderma (HP:0001029)2.19925741
85Myopathic facies (HP:0002058)2.19727354
86Lactic acidosis (HP:0003128)2.19349216
87Thoracic kyphosis (HP:0002942)2.18620922
88Tracheoesophageal fistula (HP:0002575)2.18576998
89Multiple enchondromatosis (HP:0005701)2.17770281
90Increased connective tissue (HP:0009025)2.17150453
91Glossoptosis (HP:0000162)2.16625494
92Basal cell carcinoma (HP:0002671)2.15584709
93Horseshoe kidney (HP:0000085)2.12907878
94Hyperacusis (HP:0010780)2.12219215
95Long palpebral fissure (HP:0000637)2.12151336
96Progressive muscle weakness (HP:0003323)2.11914769
97Abnormal trabecular bone morphology (HP:0100671)2.11827064
98Limb-girdle muscle atrophy (HP:0003797)2.11226260
9911 pairs of ribs (HP:0000878)2.10930903
100Absent radius (HP:0003974)2.10677966
101Abnormality of the Achilles tendon (HP:0005109)2.10643663
102Acute encephalopathy (HP:0006846)2.10606328
103Distal lower limb muscle weakness (HP:0009053)2.10501773
104Amaurosis fugax (HP:0100576)2.10128405
105Decreased activity of mitochondrial respiratory chain (HP:0008972)2.09236628
106Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.09236628
107Lymphoma (HP:0002665)2.08447967
108Fatigue (HP:0012378)2.07879288
109Distal upper limb amyotrophy (HP:0007149)2.07158017
110Upper limb amyotrophy (HP:0009129)2.07158017
111Shoulder girdle muscle weakness (HP:0003547)2.05465029
112Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.05403728
113Cleft eyelid (HP:0000625)2.05380823
114Atrophy/Degeneration involving motor neurons (HP:0007373)2.04761544
115Abnormalities of placenta or umbilical cord (HP:0001194)2.04201155
116Personality changes (HP:0000751)2.03927938
117Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.03904602
118Absent forearm bone (HP:0003953)2.01690743
119Aplasia involving forearm bones (HP:0009822)2.01690743
1203-Methylglutaconic aciduria (HP:0003535)2.01581724
121Upper limb muscle weakness (HP:0003484)2.01047167
122Reduced subcutaneous adipose tissue (HP:0003758)2.00656991
123Sloping forehead (HP:0000340)1.99693110
124Hand muscle atrophy (HP:0009130)1.97273223
125Exertional dyspnea (HP:0002875)1.97223371
126Impulsivity (HP:0100710)1.93831144
127Supernumerary spleens (HP:0009799)1.93171326
128Rhabdomyosarcoma (HP:0002859)1.92474470
129Abnormal lung lobation (HP:0002101)1.92318144
130Sparse eyelashes (HP:0000653)1.92038362
131Premature ovarian failure (HP:0008209)1.91662582
132Abnormal umbilical cord blood vessels (HP:0011403)1.90682077
133Single umbilical artery (HP:0001195)1.90682077
134Abnormality of the fetal cardiovascular system (HP:0010948)1.90682077
135Type I transferrin isoform profile (HP:0003642)1.87461540
136Exercise intolerance (HP:0003546)1.87365959
137Prolonged neonatal jaundice (HP:0006579)1.86842326
138Atresia of the external auditory canal (HP:0000413)1.86326573
139Triphalangeal thumb (HP:0001199)1.86227100
140Petechiae (HP:0000967)1.85800079
141Seborrheic dermatitis (HP:0001051)1.84120408
142Proximal placement of thumb (HP:0009623)1.82582346
143Stridor (HP:0010307)1.82319512
144Short nail (HP:0001799)1.82058990
145Duplicated collecting system (HP:0000081)1.82045385
146Broad distal phalanx of finger (HP:0009836)1.82030846
147Progressive macrocephaly (HP:0004481)1.82011395
148Secondary amenorrhea (HP:0000869)1.81771888
149Asplenia (HP:0001746)1.81523895
150Postnatal microcephaly (HP:0005484)1.81450555
151Abnormality of abdominal situs (HP:0011620)1.81096815
152Abdominal situs inversus (HP:0003363)1.81096815
153Pelvic girdle muscle weakness (HP:0003749)1.80100325
154Abnormality of the pons (HP:0007361)1.79988608
155Abnormality of the duodenum (HP:0002246)1.79514573
156Squamous cell carcinoma (HP:0002860)1.79407316
157Hypoplasia of the pons (HP:0012110)1.79076467
158Hypergonadotropic hypogonadism (HP:0000815)1.78757168
159Emotional lability (HP:0000712)1.77459794
160Distal lower limb amyotrophy (HP:0008944)1.77248774
161Insomnia (HP:0100785)1.77148157
162Spastic paraparesis (HP:0002313)1.77063847
163Opisthotonus (HP:0002179)1.76965494
164Cerebral edema (HP:0002181)1.76065910
165Abnormality of the thoracic spine (HP:0100711)1.75081022
166Muscle stiffness (HP:0003552)1.73370052
167Generalized amyotrophy (HP:0003700)1.72639141
168Hypokinesia (HP:0002375)1.72623667
169Fasciculations (HP:0002380)1.71426662

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.58142948
2VRK24.24497111
3EIF2AK14.17131211
4WEE14.11118343
5CDC73.97205701
6SMG13.26446669
7TSSK63.01120525
8STK162.81952138
9SRPK12.53417034
10EIF2AK32.44514163
11TRIB32.22058930
12NME22.21867180
13IRAK32.20067547
14TLK12.20004145
15TESK22.14550523
16VRK12.09059351
17NEK22.06656358
18MKNK12.06051649
19ERN11.95935003
20TTK1.87593113
21PLK11.76925146
22PLK41.75615614
23NEK11.68450396
24ICK1.66693303
25RPS6KB21.63600055
26ARAF1.57732900
27ATR1.57194553
28EEF2K1.54241688
29PLK31.51888085
30BRSK21.46839303
31CDK71.43728876
32AURKB1.43447959
33PAK41.39481712
34PASK1.35568456
35CHEK21.29599186
36MKNK21.29141681
37SCYL21.28433800
38MAP3K81.23788755
39NME11.23201082
40AURKA1.20845579
41MAP4K11.20095506
42RPS6KA41.20054273
43MST1R1.19664510
44PIM21.16667390
45ACVR1B1.15983109
46MARK31.12120242
47PNCK1.08507760
48DYRK31.08009936
49LMTK21.07671760
50CHEK11.06554580
51PBK1.06332416
52STK101.06191926
53CCNB11.06129575
54CDK41.05887655
55STK41.03798014
56TAOK20.97844488
57BRSK10.97831044
58MST40.97603438
59DAPK10.92833675
60MAP3K120.91236835
61ZAK0.90549833
62BLK0.89697556
63PRPF4B0.89062158
64GRK60.87699463
65ABL20.86431557
66SIK10.86258285
67CDK190.84030277
68CSNK2A20.82884063
69MAP2K20.80814278
70PAK10.80531019
71CDK90.80440001
72TTN0.77928602
73TESK10.76254508
74MAPK110.76072254
75MAP3K100.75857954
76CSNK2A10.75805759
77PIM10.75031090
78TBK10.73662584
79* CDK20.73082540
80ATM0.72934747
81MAP3K110.72868197
82RPS6KA50.72758931
83TGFBR10.69855411
84MAP2K70.65979576
85EIF2AK20.64891566
86LRRK20.63095639
87PDK20.61329987
88EPHA20.61328307
89ALK0.61296974
90ILK0.58758208
91KIT0.58042145
92LIMK10.57580622
93BTK0.57457320
94BCKDK0.56344503
95CSNK1G30.55838989
96KDR0.55596853
97MAP3K30.55022959
98CDK10.53138843
99FLT30.52559451
100PTK20.52397286
101BRD40.51222853
102IRAK20.50924999
103AKT20.50027563
104CLK10.49877545
105MTOR0.49421178
106CDK120.48508894
107CDK80.47191282
108TEC0.46935994
109PKN20.46907513
110TXK0.46725184
111BMX0.44499084
112LYN0.44467993
113CSF1R0.43887381
114PLK20.43802815
115SYK0.41855358
116BRAF0.40312364
117PRKG20.38899423
118ERBB40.38057865
119JAK30.37819211
120MAPKAPK30.37211422
121PRKCI0.36779392
122TAF10.36644206
123CSNK1E0.36073480
124IKBKB0.35761461
125MAPKAPK20.34868407
126ZAP700.34837754
127CDK140.34645181
128RPS6KL10.33748801
129RPS6KC10.33748801
130YES10.32776724
131IRAK40.32446378
132DAPK30.31945737
133CDK60.27679217
134DYRK20.27296420
135CDK11A0.27035881
136MAP2K30.26978695
137PRKDC0.24524555

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.85895174
2Mismatch repair_Homo sapiens_hsa034304.12552403
3Ribosome_Homo sapiens_hsa030103.92942995
4Proteasome_Homo sapiens_hsa030503.85971373
5RNA polymerase_Homo sapiens_hsa030203.63393996
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.44195228
7* Spliceosome_Homo sapiens_hsa030403.34609801
8RNA transport_Homo sapiens_hsa030132.94086221
9Base excision repair_Homo sapiens_hsa034102.92315005
10Homologous recombination_Homo sapiens_hsa034402.81197188
11Nucleotide excision repair_Homo sapiens_hsa034202.79964955
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.57688311
13Pyrimidine metabolism_Homo sapiens_hsa002402.45101376
14One carbon pool by folate_Homo sapiens_hsa006702.34112150
15Cell cycle_Homo sapiens_hsa041102.30951523
16Non-homologous end-joining_Homo sapiens_hsa034502.10795162
17Fanconi anemia pathway_Homo sapiens_hsa034601.99747210
18Fatty acid elongation_Homo sapiens_hsa000621.86509298
19RNA degradation_Homo sapiens_hsa030181.72134621
20Basal transcription factors_Homo sapiens_hsa030221.70706692
21mRNA surveillance pathway_Homo sapiens_hsa030151.46373113
22Purine metabolism_Homo sapiens_hsa002301.40174340
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.37950539
24Parkinsons disease_Homo sapiens_hsa050121.33674683
25Oxidative phosphorylation_Homo sapiens_hsa001901.33223583
26Epstein-Barr virus infection_Homo sapiens_hsa051691.32007894
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.31690131
28Galactose metabolism_Homo sapiens_hsa000521.31495876
29p53 signaling pathway_Homo sapiens_hsa041151.28983857
30Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.28509710
31Systemic lupus erythematosus_Homo sapiens_hsa053221.28030242
32Huntingtons disease_Homo sapiens_hsa050161.24181195
33Other glycan degradation_Homo sapiens_hsa005111.23971164
34Pyruvate metabolism_Homo sapiens_hsa006201.19519362
35Protein export_Homo sapiens_hsa030601.11005414
36Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.07439062
37Antigen processing and presentation_Homo sapiens_hsa046121.03588706
38Viral carcinogenesis_Homo sapiens_hsa052030.93160870
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.88388360
40Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.87408923
41Herpes simplex infection_Homo sapiens_hsa051680.83519907
42Oocyte meiosis_Homo sapiens_hsa041140.78288495
43Biosynthesis of amino acids_Homo sapiens_hsa012300.75298619
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75212691
45Phenylalanine metabolism_Homo sapiens_hsa003600.74794082
46Alzheimers disease_Homo sapiens_hsa050100.73703255
47Legionellosis_Homo sapiens_hsa051340.71183512
48Primary immunodeficiency_Homo sapiens_hsa053400.70261963
49Cysteine and methionine metabolism_Homo sapiens_hsa002700.70169131
50Bladder cancer_Homo sapiens_hsa052190.68567247
51Pentose phosphate pathway_Homo sapiens_hsa000300.67243118
52Vibrio cholerae infection_Homo sapiens_hsa051100.63916944
53Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61814470
54Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.60998571
55HTLV-I infection_Homo sapiens_hsa051660.60049893
56Steroid biosynthesis_Homo sapiens_hsa001000.59324546
57Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59200566
58Alcoholism_Homo sapiens_hsa050340.57366587
59Arginine and proline metabolism_Homo sapiens_hsa003300.56952942
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55689398
61Measles_Homo sapiens_hsa051620.52527134
62Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52457740
63Tyrosine metabolism_Homo sapiens_hsa003500.49867920
64Shigellosis_Homo sapiens_hsa051310.48743109
65Vitamin B6 metabolism_Homo sapiens_hsa007500.48739851
66Glycosaminoglycan degradation_Homo sapiens_hsa005310.48272859
67Apoptosis_Homo sapiens_hsa042100.47873471
68Asthma_Homo sapiens_hsa053100.47784341
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.45621404
70Lysine degradation_Homo sapiens_hsa003100.42269889
71Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41734509
72N-Glycan biosynthesis_Homo sapiens_hsa005100.40698229
73Folate biosynthesis_Homo sapiens_hsa007900.39680491
74Sulfur metabolism_Homo sapiens_hsa009200.39532721
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38092158
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37758553
77Carbon metabolism_Homo sapiens_hsa012000.36138137
78Allograft rejection_Homo sapiens_hsa053300.35784480
79Hepatitis B_Homo sapiens_hsa051610.35506491
80Glutathione metabolism_Homo sapiens_hsa004800.35279540
81Fatty acid metabolism_Homo sapiens_hsa012120.34939827
82HIF-1 signaling pathway_Homo sapiens_hsa040660.33367640
83Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.32808446
84MicroRNAs in cancer_Homo sapiens_hsa052060.32579284
85Hematopoietic cell lineage_Homo sapiens_hsa046400.32541106
86Colorectal cancer_Homo sapiens_hsa052100.30433106
87Leishmaniasis_Homo sapiens_hsa051400.29761221
88Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.29565589
89Thyroid cancer_Homo sapiens_hsa052160.29525964
90Fructose and mannose metabolism_Homo sapiens_hsa000510.29412756
91NF-kappa B signaling pathway_Homo sapiens_hsa040640.29356709
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.29280063
932-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.29091939
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.28743480
95Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.28437933
96Small cell lung cancer_Homo sapiens_hsa052220.26937112
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.26763518
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26384508
99Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.26382668
100Lysosome_Homo sapiens_hsa041420.25881473
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.25855818
102Salmonella infection_Homo sapiens_hsa051320.24490138
103Intestinal immune network for IgA production_Homo sapiens_hsa046720.24462243
104RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.22969543
105Sulfur relay system_Homo sapiens_hsa041220.22717551
106Influenza A_Homo sapiens_hsa051640.22474916
107Renin-angiotensin system_Homo sapiens_hsa046140.21870316
108Viral myocarditis_Homo sapiens_hsa054160.21101038
109Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.20548670
110Phagosome_Homo sapiens_hsa041450.19429897
111Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.19097276
112Central carbon metabolism in cancer_Homo sapiens_hsa052300.18670934
113B cell receptor signaling pathway_Homo sapiens_hsa046620.18662996
114Metabolic pathways_Homo sapiens_hsa011000.17890067
115Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.16345557
116Drug metabolism - other enzymes_Homo sapiens_hsa009830.15412754
117Pancreatic cancer_Homo sapiens_hsa052120.15151769
118Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.15121841
119Acute myeloid leukemia_Homo sapiens_hsa052210.14318675
120Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.13598539
121Cardiac muscle contraction_Homo sapiens_hsa042600.12467888
122T cell receptor signaling pathway_Homo sapiens_hsa046600.11007861
123Chronic myeloid leukemia_Homo sapiens_hsa052200.10904081
124Pathways in cancer_Homo sapiens_hsa052000.09421567
125Notch signaling pathway_Homo sapiens_hsa043300.08930125
126Selenocompound metabolism_Homo sapiens_hsa004500.08208511
127Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.07365448

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