PRPF38AP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine deamination (GO:0009972)7.50307155
2cytidine metabolic process (GO:0046087)7.50307155
3cytidine catabolic process (GO:0006216)7.50307155
4DNA deamination (GO:0045006)7.23716335
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450917.03229881
6T cell migration (GO:0072678)6.86927433
7pyrimidine ribonucleoside catabolic process (GO:0046133)6.35637747
8positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.20769805
9positive regulation of gamma-delta T cell activation (GO:0046645)4.77734947
10Arp2/3 complex-mediated actin nucleation (GO:0034314)4.58360711
11regulation of gamma-delta T cell differentiation (GO:0045586)4.52482084
12positive regulation of monocyte chemotaxis (GO:0090026)4.47152287
13mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.39997401
14lymphocyte chemotaxis (GO:0048247)4.38792064
15actin nucleation (GO:0045010)4.23253554
16negative regulation by host of viral transcription (GO:0043922)4.07959103
17positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.95727825
18lymphocyte migration (GO:0072676)3.95041314
19positive regulation of amino acid transport (GO:0051957)3.86104755
20platelet dense granule organization (GO:0060155)3.85688741
21positive regulation of natural killer cell mediated immunity (GO:0002717)3.84896139
22negative thymic T cell selection (GO:0045060)3.74524179
23regulation of gamma-delta T cell activation (GO:0046643)3.74257321
24positive regulation of alpha-beta T cell proliferation (GO:0046641)3.73812375
25negative regulation of T cell apoptotic process (GO:0070233)3.72486114
26eosinophil chemotaxis (GO:0048245)3.70837260
27negative T cell selection (GO:0043383)3.68711955
28positive regulation of interleukin-8 secretion (GO:2000484)3.67095544
29positive regulation of T cell chemotaxis (GO:0010820)3.66342002
30regulation of T cell chemotaxis (GO:0010819)3.66342002
31energy coupled proton transport, down electrochemical gradient (GO:0015985)3.60068128
32ATP synthesis coupled proton transport (GO:0015986)3.60068128
33regulation of regulatory T cell differentiation (GO:0045589)3.58190568
34positive thymic T cell selection (GO:0045059)3.58064337
35positive regulation of actin filament depolymerization (GO:0030836)3.51281629
36macrophage chemotaxis (GO:0048246)3.48780294
37relaxation of smooth muscle (GO:0044557)3.47666622
38cellular response to interleukin-15 (GO:0071350)3.46948084
39endocardial cushion morphogenesis (GO:0003203)3.46549108
40positive regulation of defense response to virus by host (GO:0002230)3.44889104
41pyrimidine nucleoside catabolic process (GO:0046135)3.43915203
42interferon-gamma production (GO:0032609)3.38074481
43eosinophil migration (GO:0072677)3.34785419
44L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.33507601
45cytolysis (GO:0019835)3.30143528
46establishment of protein localization to mitochondrial membrane (GO:0090151)3.30097233
47chaperone mediated protein folding requiring cofactor (GO:0051085)3.21949554
48positive regulation of calcium-mediated signaling (GO:0050850)3.21000671
49negative regulation of execution phase of apoptosis (GO:1900118)3.20074358
50positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.16719440
51artery smooth muscle contraction (GO:0014824)3.16181715
52cellular defense response (GO:0006968)3.15133700
53regulation of T cell receptor signaling pathway (GO:0050856)3.15078114
54mesenchymal cell development (GO:0014031)3.11717885
55regulation of natural killer cell mediated immunity (GO:0002715)3.10619232
56regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.10619232
57stem cell development (GO:0048864)3.08625717
58chemokine-mediated signaling pathway (GO:0070098)3.04385524
59negative regulation of viral genome replication (GO:0045071)3.03102956
60regulation of chronic inflammatory response (GO:0002676)3.00640423
61T cell receptor signaling pathway (GO:0050852)2.99058470
62regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.98930908
63thymic T cell selection (GO:0045061)2.97104315
64positive regulation of B cell differentiation (GO:0045579)2.96814788
65iron-sulfur cluster assembly (GO:0016226)2.94492036
66metallo-sulfur cluster assembly (GO:0031163)2.94492036
67neural crest cell development (GO:0014032)2.93890468
68behavioral response to nicotine (GO:0035095)2.92387797
69regulation of alpha-beta T cell proliferation (GO:0046640)2.89632371
70positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.88326813
71regulation of activation of Janus kinase activity (GO:0010533)2.87260605
72positive regulation of uterine smooth muscle contraction (GO:0070474)2.85079799
73regulation of monocyte chemotaxis (GO:0090025)2.79501644
74regulation of B cell receptor signaling pathway (GO:0050855)2.75974909
75histamine secretion (GO:0001821)2.75884466
76regulation of lymphocyte chemotaxis (GO:1901623)2.75235630
77L-methionine salvage (GO:0071267)2.74799169
78L-methionine biosynthetic process (GO:0071265)2.74799169
79amino acid salvage (GO:0043102)2.74799169
80regulation of leukocyte mediated cytotoxicity (GO:0001910)2.74624302
81T cell mediated immunity (GO:0002456)2.74072459
82positive regulation of odontogenesis (GO:0042482)2.71995314
83dendritic cell chemotaxis (GO:0002407)2.70268006
84positive T cell selection (GO:0043368)2.66417647
85positive regulation of granulocyte differentiation (GO:0030854)2.65178244
86CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.63171247
87T-helper cell differentiation (GO:0042093)2.63171247
88positive regulation of cell killing (GO:0031343)2.63039078
89positive regulation of T cell migration (GO:2000406)2.60625580
90negative regulation of viral transcription (GO:0032897)2.60567795
91positive regulation of lymphocyte migration (GO:2000403)2.59689712
92regulation of interleukin-8 secretion (GO:2000482)2.59083954
93regulation of B cell differentiation (GO:0045577)2.57333409
94intestinal cholesterol absorption (GO:0030299)2.56040047
95regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.54996672
96tonic smooth muscle contraction (GO:0014820)2.54827840
97somite development (GO:0061053)2.53942388
98alpha-beta T cell differentiation involved in immune response (GO:0002293)2.53190224
99alpha-beta T cell activation involved in immune response (GO:0002287)2.53190224
100T cell differentiation involved in immune response (GO:0002292)2.53190224

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.62068796
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.09229091
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.64892081
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.53052853
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.50952260
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.38061431
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.19895964
8CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.73827887
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.72995470
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.70977638
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.63923275
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.62217907
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.57511776
14STAT6_21828071_ChIP-Seq_BEAS2B_Human2.53391998
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.50914737
16MYB_26560356_Chip-Seq_TH2_Human2.49934254
17IRF8_22096565_ChIP-ChIP_GC-B_Human2.46974858
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.42381728
19ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.25996606
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.20648040
21RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.19287979
22NOTCH1_21737748_ChIP-Seq_TLL_Human2.18551356
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.93605444
24FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.92238823
25VDR_23849224_ChIP-Seq_CD4+_Human1.91497218
26RUNX_20019798_ChIP-Seq_JUKART_Human1.88711988
27STAT4_19710469_ChIP-ChIP_TH1__Mouse1.87987066
28LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.87227160
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.80882953
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.80437160
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.79743684
32GATA3_26560356_Chip-Seq_TH2_Human1.78043631
33SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.75794931
34VDR_22108803_ChIP-Seq_LS180_Human1.73490662
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71280234
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.66219635
37GATA3_27048872_Chip-Seq_THYMUS_Human1.60831056
38FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.59216135
39SRF_21415370_ChIP-Seq_HL-1_Mouse1.53686420
40PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.53564464
41ZNF274_21170338_ChIP-Seq_K562_Hela1.52550694
42EST1_17652178_ChIP-ChIP_JURKAT_Human1.52096301
43CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.43364214
44MYC_18940864_ChIP-ChIP_HL60_Human1.41701834
45EZH2_22144423_ChIP-Seq_EOC_Human1.40493240
46UTX_26944678_Chip-Seq_JUKART_Human1.34791129
47POU5F1_16153702_ChIP-ChIP_HESCs_Human1.33742459
48TAF2_19829295_ChIP-Seq_ESCs_Human1.32818100
49ETS1_20019798_ChIP-Seq_JURKAT_Human1.30908628
50MYB_26560356_Chip-Seq_TH1_Human1.30175577
51ELK1_19687146_ChIP-ChIP_HELA_Human1.25206808
52EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.24147588
53STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.24005143
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.22153839
55NANOG_20526341_ChIP-Seq_ESCs_Human1.20896019
56RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.19374724
57AR_20517297_ChIP-Seq_VCAP_Human1.18801553
58MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.17051650
59GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.16528083
60FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.13734588
61FOXA1_27270436_Chip-Seq_PROSTATE_Human1.13263587
62FOXA1_25329375_ChIP-Seq_VCAP_Human1.13263587
63NANOG_19829295_ChIP-Seq_ESCs_Human1.10114599
64SOX2_19829295_ChIP-Seq_ESCs_Human1.10114599
65RNF2_27304074_Chip-Seq_NSC_Mouse1.09367157
66PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.07615807
67TP53_22573176_ChIP-Seq_HFKS_Human1.06721047
68FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02249047
69FOXP3_21729870_ChIP-Seq_TREG_Human1.01398093
70HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.01212333
71MAF_26560356_Chip-Seq_TH2_Human1.00857934
72FLI1_27457419_Chip-Seq_LIVER_Mouse1.00426866
73GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00144740
74GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.99249388
75MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98736253
76CIITA_25753668_ChIP-Seq_RAJI_Human0.98275728
77TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.97685554
78MAF_26560356_Chip-Seq_TH1_Human0.97086255
79EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.95911381
80E2F1_17053090_ChIP-ChIP_MCF-7_Human0.94731719
81POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94418925
82EWS_26573619_Chip-Seq_HEK293_Human0.91951645
83CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.91463966
84AR_21572438_ChIP-Seq_LNCaP_Human0.90056965
85BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.88868450
86BCL6_27268052_Chip-Seq_Bcells_Human0.88650398
87FLI1_21867929_ChIP-Seq_CD8_Mouse0.88468820
88EED_16625203_ChIP-ChIP_MESCs_Mouse0.88279107
89JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87509178
90GATA3_26560356_Chip-Seq_TH1_Human0.86608756
91RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.85917191
92HTT_18923047_ChIP-ChIP_STHdh_Human0.85776387
93CREB1_15753290_ChIP-ChIP_HEK293T_Human0.84909227
94PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.84514391
95HOXB4_20404135_ChIP-ChIP_EML_Mouse0.84188767
96YY1_22570637_ChIP-Seq_MALME-3M_Human0.83808392
97GATA6_21074721_ChIP-Seq_CACO-2_Human0.82424524
98PHF8_20622853_ChIP-Seq_HELA_Human0.82284282
99IKZF1_21737484_ChIP-ChIP_HCT116_Human0.81004494
100SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.80977249

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.06341506
2MP0003045_fibrosis3.52436271
3MP0003763_abnormal_thymus_physiology3.29413050
4MP0009785_altered_susceptibility_to3.24685758
5MP0004145_abnormal_muscle_electrophysio3.08012632
6MP0000566_synostosis2.78527861
7MP0010368_abnormal_lymphatic_system2.37143502
8MP0009333_abnormal_splenocyte_physiolog2.36301880
9MP0000569_abnormal_digit_pigmentation2.31945604
10MP0005645_abnormal_hypothalamus_physiol2.30680752
11MP0005075_abnormal_melanosome_morpholog2.26685911
12MP0001879_abnormal_lymphatic_vessel2.22042831
13MP0005623_abnormal_meninges_morphology2.13564185
14MP0001800_abnormal_humoral_immune2.09286852
15MP0001986_abnormal_taste_sensitivity2.08486557
16MP0003646_muscle_fatigue2.00867529
17MP0003866_abnormal_defecation1.99624875
18MP0001542_abnormal_bone_strength1.95267369
19MP0003448_altered_tumor_morphology1.89029138
20MP0006082_CNS_inflammation1.88613208
21MP0003075_altered_response_to1.83636959
22MP0004381_abnormal_hair_follicle1.79601020
23MP0002166_altered_tumor_susceptibility1.79253017
24MP0002148_abnormal_hypersensitivity_rea1.74695263
25MP0002723_abnormal_immune_serum1.74601031
26MP0002420_abnormal_adaptive_immunity1.67532692
27MP0005000_abnormal_immune_tolerance1.65996991
28MP0005025_abnormal_response_to1.63076585
29MP0005166_decreased_susceptibility_to1.61707143
30MP0000049_abnormal_middle_ear1.60933186
31MP0001819_abnormal_immune_cell1.56542619
32MP0003941_abnormal_skin_development1.50971810
33MP0009697_abnormal_copulation1.48654143
34MP0002405_respiratory_system_inflammati1.47773855
35MP0002009_preneoplasia1.47611811
36MP0000516_abnormal_urinary_system1.47598038
37MP0005367_renal/urinary_system_phenotyp1.47598038
38MP0003137_abnormal_impulse_conducting1.47350700
39MP0000538_abnormal_urinary_bladder1.45181107
40MP0005360_urolithiasis1.44124647
41MP0010030_abnormal_orbit_morphology1.42846195
42MP0005377_hearing/vestibular/ear_phenot1.41618203
43MP0003878_abnormal_ear_physiology1.41618203
44MP0001835_abnormal_antigen_presentation1.38148380
45MP0000703_abnormal_thymus_morphology1.35650192
46MP0002452_abnormal_antigen_presenting1.33900007
47MP0002006_tumorigenesis1.33485180
48MP0003283_abnormal_digestive_organ1.33143467
49MP0002938_white_spotting1.29158221
50MP0003724_increased_susceptibility_to1.27565545
51MP0001324_abnormal_eye_pigmentation1.27367846
52MP0002722_abnormal_immune_system1.20050846
53MP0001790_abnormal_immune_system1.18303771
54MP0005387_immune_system_phenotype1.18303771
55MP0003195_calcinosis1.18043467
56MP0005084_abnormal_gallbladder_morpholo1.17132450
57MP0002102_abnormal_ear_morphology1.17019789
58MP0002095_abnormal_skin_pigmentation1.13267101
59MP0004742_abnormal_vestibular_system1.13254927
60MP0002933_joint_inflammation1.11006927
61MP0002398_abnormal_bone_marrow1.09501338
62MP0000716_abnormal_immune_system1.08437315
63MP0000372_irregular_coat_pigmentation1.07069831
64MP0008995_early_reproductive_senescence1.06971764
65MP0002168_other_aberrant_phenotype1.06544649
66MP0001485_abnormal_pinna_reflex1.06236740
67MP0003786_premature_aging1.01025559
68MP0000689_abnormal_spleen_morphology0.99612924
69MP0000015_abnormal_ear_pigmentation0.99364308
70MP0010155_abnormal_intestine_physiology0.98185115
71MP0000230_abnormal_systemic_arterial0.97749013
72MP0003806_abnormal_nucleotide_metabolis0.97660914
73MP0001845_abnormal_inflammatory_respons0.94412795
74MP0000604_amyloidosis0.93861715
75MP0005464_abnormal_platelet_physiology0.90762025
76MP0005165_increased_susceptibility_to0.89904183
77MP0001243_abnormal_dermal_layer0.89107681
78MP0006072_abnormal_retinal_apoptosis0.88772458
79MP0003693_abnormal_embryo_hatching0.87660575
80MP0005551_abnormal_eye_electrophysiolog0.85531859
81MP0002419_abnormal_innate_immunity0.85381285
82MP0001905_abnormal_dopamine_level0.81013260
83MP0008469_abnormal_protein_level0.80040237
84MP0005423_abnormal_somatic_nervous0.79341315
85MP0003938_abnormal_ear_development0.78142452
86MP0002429_abnormal_blood_cell0.74955421
87MP0000537_abnormal_urethra_morphology0.72949981
88MP0001119_abnormal_female_reproductive0.72840745
89MP0008789_abnormal_olfactory_epithelium0.72498903
90MP0004084_abnormal_cardiac_muscle0.71886781
91MP0004147_increased_porphyrin_level0.69459606
92MP0009764_decreased_sensitivity_to0.68967359
93MP0009053_abnormal_anal_canal0.68868097
94MP0002019_abnormal_tumor_incidence0.68327645
95MP0009643_abnormal_urine_homeostasis0.67405629
96MP0005584_abnormal_enzyme/coenzyme_acti0.65574908
97MP0003436_decreased_susceptibility_to0.65216394
98MP0000685_abnormal_immune_system0.62215029
99MP0001873_stomach_inflammation0.61235257
100MP0002277_abnormal_respiratory_mucosa0.60987797

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)5.85290767
2Abnormality of T cell number (HP:0011839)5.58991018
3Aplastic anemia (HP:0001915)5.49644626
4Hypoproteinemia (HP:0003075)5.01626093
5Severe combined immunodeficiency (HP:0004430)4.78140372
6IgG deficiency (HP:0004315)4.59989709
7Abnormality of T cells (HP:0002843)4.15131838
8Elevated erythrocyte sedimentation rate (HP:0003565)3.89512622
9Combined immunodeficiency (HP:0005387)3.76825746
10Congenital, generalized hypertrichosis (HP:0004540)3.75839243
11Increased IgM level (HP:0003496)3.55521186
12Stomatitis (HP:0010280)3.41122139
13Bilateral microphthalmos (HP:0007633)3.39476595
14Hemiplegia (HP:0002301)3.34922519
15Autoimmune thrombocytopenia (HP:0001973)3.25485499
16Abnormal delayed hypersensitivity skin test (HP:0002963)3.15385680
17Thyroiditis (HP:0100646)3.13131960
18Anencephaly (HP:0002323)3.12591845
19Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.12534438
20Encephalitis (HP:0002383)3.11669827
21Autoimmune hemolytic anemia (HP:0001890)3.11096199
22Nausea (HP:0002018)3.04527746
23Aplasia/Hypoplasia of the sternum (HP:0006714)3.01306480
24Opisthotonus (HP:0002179)3.00999181
25Recurrent cutaneous fungal infections (HP:0011370)2.97356300
26Chronic mucocutaneous candidiasis (HP:0002728)2.97356300
27Reduced antithrombin III activity (HP:0001976)2.92178151
28Chronic diarrhea (HP:0002028)2.91325287
29Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.90735861
30Abnormal protein N-linked glycosylation (HP:0012347)2.90735861
31Abnormal protein glycosylation (HP:0012346)2.90735861
32Abnormal glycosylation (HP:0012345)2.90735861
33Abnormality of the pubic bones (HP:0003172)2.88374701
34Panhypogammaglobulinemia (HP:0003139)2.83734045
35True hermaphroditism (HP:0010459)2.80888456
36Concave nail (HP:0001598)2.80698034
37Exertional dyspnea (HP:0002875)2.76719410
38Abnormality of eosinophils (HP:0001879)2.75810996
393-Methylglutaconic aciduria (HP:0003535)2.75032655
40Morphological abnormality of the middle ear (HP:0008609)2.72871988
41Abnormality of macrophages (HP:0004311)2.63525862
42Hepatocellular necrosis (HP:0001404)2.61670767
43Aplasia/Hypoplasia of the hallux (HP:0008362)2.61569703
44Pancytopenia (HP:0001876)2.59088086
45Large for gestational age (HP:0001520)2.55694774
46Abnormality of T cell physiology (HP:0011840)2.55332458
47Hypoalbuminemia (HP:0003073)2.53425564
48Abnormal albumin level (HP:0012116)2.53425564
49Congenital ichthyosiform erythroderma (HP:0007431)2.45636266
50Amelogenesis imperfecta (HP:0000705)2.43175941
51Meningitis (HP:0001287)2.38584362
52Recurrent corneal erosions (HP:0000495)2.37106871
53Abolished electroretinogram (ERG) (HP:0000550)2.34496436
54Hepatic necrosis (HP:0002605)2.31931947
55Pancreatic fibrosis (HP:0100732)2.30115751
56Mitochondrial inheritance (HP:0001427)2.28969560
57Agammaglobulinemia (HP:0004432)2.24749501
58Short hallux (HP:0010109)2.22685850
59Abnormality of B cell number (HP:0010975)2.22376084
60Choroideremia (HP:0001139)2.19761059
61Increased neuronal autofluorescent lipopigment (HP:0002074)2.18785606
62Type I transferrin isoform profile (HP:0003642)2.17777266
63Recurrent viral infections (HP:0004429)2.09603346
64Congenital stationary night blindness (HP:0007642)2.09485179
65Abnormal lung lobation (HP:0002101)2.02576709
66Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.02296526
67Pancreatic cysts (HP:0001737)2.00490635
68Recurrent fungal infections (HP:0002841)2.00072228
69Lymphoma (HP:0002665)1.98941578
70Leukocytosis (HP:0001974)1.97598798
71Eosinophilia (HP:0001880)1.93024650
72Spastic paraparesis (HP:0002313)1.90893055
73Palpebral edema (HP:0100540)1.89198793
74Constricted visual fields (HP:0001133)1.88037934
75Polyuria (HP:0000103)1.86089400
76Cerebral hypomyelination (HP:0006808)1.85814321
77Recurrent skin infections (HP:0001581)1.83122047
78Acute necrotizing encephalopathy (HP:0006965)1.82917852
79Obstructive lung disease (HP:0006536)1.81020193
80Chronic obstructive pulmonary disease (HP:0006510)1.81020193
81Increased CSF lactate (HP:0002490)1.80901211
82Recurrent bronchitis (HP:0002837)1.80499410
83Periorbital edema (HP:0100539)1.78413746
84Abnormality of the renal collecting system (HP:0004742)1.77660835
85Sclerocornea (HP:0000647)1.76300774
86Recurrent abscess formation (HP:0002722)1.73547354
87Facial edema (HP:0000282)1.73235570
88Midline defect of the nose (HP:0004122)1.71647216
89Prominent supraorbital ridges (HP:0000336)1.71629946
90Pigmentary retinal degeneration (HP:0001146)1.71246817
91Abnormal drinking behavior (HP:0030082)1.70954087
92Polydipsia (HP:0001959)1.70954087
93Furrowed tongue (HP:0000221)1.70434064
94Parakeratosis (HP:0001036)1.69659273
95Renal duplication (HP:0000075)1.68245093
96Hemiparesis (HP:0001269)1.64970252
97Abnormal hemoglobin (HP:0011902)1.64158650
98Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.63733878
99Increased cerebral lipofuscin (HP:0011813)1.63698869
100Duplicated collecting system (HP:0000081)1.62999791

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK26.91588216
2TXK5.54813238
3MAP3K103.87853557
4PNCK3.66234372
5KDR3.20630600
6TESK13.18006316
7LIMK12.98665450
8MAPK152.58358536
9ITK2.43308313
10TLK12.41564104
11WEE12.41208859
12BCKDK2.41017979
13MAP4K22.27773988
14NME12.27400862
15ZAK1.95491593
16PASK1.84794687
17MAP4K11.66192858
18VRK11.59861811
19VRK21.52068784
20ZAP701.51280182
21CSK1.30174697
22MST41.28553489
23CASK1.23732427
24PIM21.19891068
25ADRBK21.12973235
26STK38L1.07731127
27TSSK61.00606002
28TAOK30.99950225
29SYK0.97798562
30NLK0.91767452
31MAP3K120.90402975
32RPS6KA50.89896786
33CDC70.86219901
34FES0.80983498
35PRKCQ0.79842169
36GRK10.76266003
37LCK0.76093544
38KIT0.73690394
39PIM10.71585273
40GRK70.70218474
41IKBKB0.69641378
42LATS10.66697174
43ABL20.64738837
44PIK3CG0.64034699
45PRKG20.63653156
46TEC0.62432975
47WNK40.60641744
48NUAK10.57943545
49CLK10.57890988
50LYN0.57556041
51ADRBK10.56429771
52MAP2K20.56314455
53IRAK40.55260447
54JAK30.53699780
55IKBKE0.51820349
56BTK0.51483362
57MAPKAPK30.51428834
58EPHA30.50724211
59IGF1R0.50358632
60CAMKK10.48600871
61CAMKK20.48511121
62MAP3K110.47279053
63SCYL20.46597756
64NEK20.45703383
65CSF1R0.45624242
66DYRK1B0.44552028
67MAPKAPK50.44490477
68ROCK10.44287704
69FYN0.44192449
70DAPK10.43157610
71PDGFRB0.42591980
72OXSR10.42202443
73OBSCN0.41941669
74BMPR1B0.40698191
75NEK10.39863246
76CAMK2B0.39161007
77GRK60.37237893
78INSRR0.37237455
79RAF10.36204737
80FRK0.34898695
81CAMK2A0.32541658
82PAK30.31802317
83MYLK0.31292628
84JAK20.31086328
85INSR0.30123735
86ERBB20.29977153
87CSNK2A10.28197673
88AURKA0.28019360
89CAMK2G0.26963669
90MAPK130.26728722
91CHUK0.26293475
92TAOK10.25795543
93RPS6KA40.25217910
94PRKCA0.25136862
95PRKACA0.24144185
96STK390.23713037
97TGFBR10.19495055
98MUSK0.17973588
99PRKD10.16290688
100EPHB20.15582375

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.95747709
2Proteasome_Homo sapiens_hsa030503.85022222
3Oxidative phosphorylation_Homo sapiens_hsa001903.05399681
4Antigen processing and presentation_Homo sapiens_hsa046122.85435125
5Parkinsons disease_Homo sapiens_hsa050122.76215590
6Autoimmune thyroid disease_Homo sapiens_hsa053202.74618134
7Graft-versus-host disease_Homo sapiens_hsa053322.72736039
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.67757443
9Allograft rejection_Homo sapiens_hsa053302.58321162
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.35537367
11T cell receptor signaling pathway_Homo sapiens_hsa046602.31227310
12RNA polymerase_Homo sapiens_hsa030202.19059848
13Type I diabetes mellitus_Homo sapiens_hsa049402.13473442
14Ribosome_Homo sapiens_hsa030102.13435242
15Sulfur metabolism_Homo sapiens_hsa009202.07605868
16Hematopoietic cell lineage_Homo sapiens_hsa046401.90686891
17Protein export_Homo sapiens_hsa030601.80960243
18Alzheimers disease_Homo sapiens_hsa050101.63843563
19Phototransduction_Homo sapiens_hsa047441.52968560
20SNARE interactions in vesicular transport_Homo sapiens_hsa041301.52249435
21Rheumatoid arthritis_Homo sapiens_hsa053231.52233318
22Huntingtons disease_Homo sapiens_hsa050161.43154910
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.38698568
24Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.37816424
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.35599331
26Cardiac muscle contraction_Homo sapiens_hsa042601.34949412
27NF-kappa B signaling pathway_Homo sapiens_hsa040641.17478413
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.15525913
29Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.11225510
30Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.10818091
31Selenocompound metabolism_Homo sapiens_hsa004501.08104638
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.07533746
33Purine metabolism_Homo sapiens_hsa002301.05028776
34Collecting duct acid secretion_Homo sapiens_hsa049661.00529214
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.00464983
36Caffeine metabolism_Homo sapiens_hsa002320.96822573
37Measles_Homo sapiens_hsa051620.91731550
38Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.91523195
39NOD-like receptor signaling pathway_Homo sapiens_hsa046210.90764922
40Shigellosis_Homo sapiens_hsa051310.88990673
41Nicotine addiction_Homo sapiens_hsa050330.85279333
42Malaria_Homo sapiens_hsa051440.85241084
43Linoleic acid metabolism_Homo sapiens_hsa005910.83978974
44Olfactory transduction_Homo sapiens_hsa047400.82397145
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82037517
46Vascular smooth muscle contraction_Homo sapiens_hsa042700.79088934
47Viral myocarditis_Homo sapiens_hsa054160.78601205
48Taste transduction_Homo sapiens_hsa047420.77536601
49Salivary secretion_Homo sapiens_hsa049700.77272279
50Steroid hormone biosynthesis_Homo sapiens_hsa001400.76559468
51Steroid biosynthesis_Homo sapiens_hsa001000.71348026
52Nitrogen metabolism_Homo sapiens_hsa009100.71324729
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.69244401
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67234329
55Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.66822972
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66751152
57Peroxisome_Homo sapiens_hsa041460.65725313
58Pyrimidine metabolism_Homo sapiens_hsa002400.63828094
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61602318
60RNA degradation_Homo sapiens_hsa030180.61504077
61Chemical carcinogenesis_Homo sapiens_hsa052040.60694342
62RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.59826021
63Fanconi anemia pathway_Homo sapiens_hsa034600.52055713
64Homologous recombination_Homo sapiens_hsa034400.51733761
65Systemic lupus erythematosus_Homo sapiens_hsa053220.51558322
66Sulfur relay system_Homo sapiens_hsa041220.50537062
67Spliceosome_Homo sapiens_hsa030400.50180522
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49832791
69Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.49334645
70Asthma_Homo sapiens_hsa053100.48689300
71Salmonella infection_Homo sapiens_hsa051320.47521485
72Amphetamine addiction_Homo sapiens_hsa050310.47208253
73Vitamin digestion and absorption_Homo sapiens_hsa049770.44301282
74Renin secretion_Homo sapiens_hsa049240.43918896
75Calcium signaling pathway_Homo sapiens_hsa040200.43506789
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.43232190
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.43000749
78TNF signaling pathway_Homo sapiens_hsa046680.42718257
79Legionellosis_Homo sapiens_hsa051340.41997096
80Retinol metabolism_Homo sapiens_hsa008300.39197084
81Chemokine signaling pathway_Homo sapiens_hsa040620.38928494
82Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.38834535
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38348885
84Mismatch repair_Homo sapiens_hsa034300.37301336
85Apoptosis_Homo sapiens_hsa042100.35792262
86Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.35071314
87Butanoate metabolism_Homo sapiens_hsa006500.34828028
88Regulation of autophagy_Homo sapiens_hsa041400.33972806
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.32877461
90Circadian entrainment_Homo sapiens_hsa047130.31392470
91Fat digestion and absorption_Homo sapiens_hsa049750.28217101
92Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.27295446
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.26719224
94Toll-like receptor signaling pathway_Homo sapiens_hsa046200.26642230
95HTLV-I infection_Homo sapiens_hsa051660.25951406
96Arachidonic acid metabolism_Homo sapiens_hsa005900.25231910
97Prion diseases_Homo sapiens_hsa050200.24450726
98DNA replication_Homo sapiens_hsa030300.23884198
99Morphine addiction_Homo sapiens_hsa050320.23343590
100Basal transcription factors_Homo sapiens_hsa030220.23006220

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