PRPF40B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a WW-domain containing protein similar to yeast splicing factor PRP40. This protein has been shown to interact with Huntingtin and methyl CpG binding protein 2 (MeCP2). Alternative splicing results in different transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)4.60373492
2positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.57202143
3vocalization behavior (GO:0071625)4.36041065
4locomotory exploration behavior (GO:0035641)4.29241609
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.19202259
6synaptic vesicle maturation (GO:0016188)4.12056255
7ionotropic glutamate receptor signaling pathway (GO:0035235)4.11230731
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.09912835
9neuron cell-cell adhesion (GO:0007158)4.07590171
10regulation of synaptic vesicle exocytosis (GO:2000300)4.03999740
11protein localization to synapse (GO:0035418)3.92016436
12synaptic vesicle exocytosis (GO:0016079)3.89346879
13cell migration in hindbrain (GO:0021535)3.85105996
14layer formation in cerebral cortex (GO:0021819)3.80873426
15neuron recognition (GO:0008038)3.74083972
16regulation of glutamate receptor signaling pathway (GO:1900449)3.73480713
17synaptic vesicle docking involved in exocytosis (GO:0016081)3.69821730
18axonal fasciculation (GO:0007413)3.61542778
19synaptic transmission, glutamatergic (GO:0035249)3.60368651
20glutamate receptor signaling pathway (GO:0007215)3.54195713
21dendritic spine morphogenesis (GO:0060997)3.51273354
22regulation of synaptic vesicle transport (GO:1902803)3.51087133
23glutamate secretion (GO:0014047)3.48604667
24exploration behavior (GO:0035640)3.47748654
25regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.46429665
26regulation of neuronal synaptic plasticity (GO:0048168)3.45781899
27neuronal ion channel clustering (GO:0045161)3.33554630
28postsynaptic membrane organization (GO:0001941)3.30706941
29regulation of vesicle fusion (GO:0031338)3.26935345
30neurotransmitter secretion (GO:0007269)3.26356214
31cell communication by electrical coupling (GO:0010644)3.25037291
32neuron-neuron synaptic transmission (GO:0007270)3.21655589
33cerebellar Purkinje cell differentiation (GO:0021702)3.14648620
34membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.12730781
35neuronal action potential propagation (GO:0019227)3.07387197
36regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.06679256
37regulation of excitatory postsynaptic membrane potential (GO:0060079)3.06003116
38regulation of synapse structural plasticity (GO:0051823)3.04255207
39dendrite morphogenesis (GO:0048813)3.03887132
40positive regulation of synapse maturation (GO:0090129)3.03855576
41negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.01535653
42neurotransmitter-gated ion channel clustering (GO:0072578)3.01367343
43presynaptic membrane organization (GO:0097090)3.01328968
44regulation of postsynaptic membrane potential (GO:0060078)2.99953153
45regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.99123464
46regulation of long-term neuronal synaptic plasticity (GO:0048169)2.96037585
47response to pheromone (GO:0019236)2.92576547
48transmission of nerve impulse (GO:0019226)2.91369664
49cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.88623130
50membrane depolarization during action potential (GO:0086010)2.87694245
51gamma-aminobutyric acid transport (GO:0015812)2.83745068
52synaptic vesicle endocytosis (GO:0048488)2.81502729
53establishment of mitochondrion localization (GO:0051654)2.80640475
54positive regulation of synaptic transmission, GABAergic (GO:0032230)2.78794806
55presynaptic membrane assembly (GO:0097105)2.78411990
56long-term memory (GO:0007616)2.74987288
57regulation of neurotransmitter secretion (GO:0046928)2.72229449
58regulation of dendritic spine morphogenesis (GO:0061001)2.71673926
59positive regulation of membrane potential (GO:0045838)2.71361974
60neuromuscular process controlling posture (GO:0050884)2.69948225
61neurotransmitter transport (GO:0006836)2.69162350
62neuromuscular process controlling balance (GO:0050885)2.69045871
63membrane hyperpolarization (GO:0060081)2.68469891
64central nervous system projection neuron axonogenesis (GO:0021952)2.68042803
65membrane depolarization (GO:0051899)2.67795101
66auditory behavior (GO:0031223)2.67233298
67establishment of nucleus localization (GO:0040023)2.66710139
68cerebellar granule cell differentiation (GO:0021707)2.65727214
69positive regulation of synapse assembly (GO:0051965)2.63829870
70planar cell polarity pathway involved in neural tube closure (GO:0090179)2.62331330
71positive regulation of dendritic spine development (GO:0060999)2.61608213
72activation of protein kinase A activity (GO:0034199)2.61423271
73innervation (GO:0060384)2.61246795
74synapse assembly (GO:0007416)2.60663969
75sodium ion export (GO:0071436)2.60551212
76neuromuscular synaptic transmission (GO:0007274)2.60261727
77regulation of synapse maturation (GO:0090128)2.59620472
78synapse organization (GO:0050808)2.59411137
79adult walking behavior (GO:0007628)2.59035322
80pyrimidine nucleobase catabolic process (GO:0006208)2.57673882
81hippocampus development (GO:0021766)2.56462518
82G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.54920361
83negative regulation of cytosolic calcium ion concentration (GO:0051481)2.54816122
84positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.53336351
85regulation of synaptic plasticity (GO:0048167)2.53020913
86mating behavior (GO:0007617)2.52019067
87negative regulation of synaptic transmission, GABAergic (GO:0032229)2.50586547
88proline transport (GO:0015824)2.50478500
89regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.50336628
90positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.49910271
91synaptonemal complex assembly (GO:0007130)2.49764123
92regulation of respiratory system process (GO:0044065)2.47709255
93regulation of neurotransmitter transport (GO:0051588)2.47015786
94cell differentiation in hindbrain (GO:0021533)2.44716800
95cochlea development (GO:0090102)2.44676673
96neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.44609833
97regulation of neurotransmitter levels (GO:0001505)2.44135216
98positive regulation of neurotransmitter transport (GO:0051590)2.44100262
99regulation of synaptic transmission, glutamatergic (GO:0051966)2.43953758
100cerebellar Purkinje cell layer development (GO:0021680)2.43703309
101cellular potassium ion homeostasis (GO:0030007)2.42718882
102learning (GO:0007612)2.41226862
103neuromuscular junction development (GO:0007528)2.40850077
104negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.40365564
105calcium ion-dependent exocytosis (GO:0017156)2.39665505
106regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.39258102
107striatum development (GO:0021756)2.38968440
108negative regulation of oligodendrocyte differentiation (GO:0048715)2.38365644
109paraxial mesoderm development (GO:0048339)2.35425109
110semaphorin-plexin signaling pathway (GO:0071526)2.34819335
111apical protein localization (GO:0045176)2.32560527
112brain morphogenesis (GO:0048854)2.30888327
113ephrin receptor signaling pathway (GO:0048013)2.30253528
114dendritic spine organization (GO:0097061)2.27906760
115establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.27464915
116mitochondrion transport along microtubule (GO:0047497)2.27464915
117negative regulation of fibroblast apoptotic process (GO:2000270)2.25356665
118synaptonemal complex organization (GO:0070193)2.24757897
119calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.24740543
120regulation of axon guidance (GO:1902667)2.21864327
121negative regulation of osteoblast proliferation (GO:0033689)2.21779458
122histone H3-K9 demethylation (GO:0033169)2.21703399
123detection of calcium ion (GO:0005513)2.16717047
124chemosensory behavior (GO:0007635)2.16258520
125convergent extension (GO:0060026)2.15241392
126cilium or flagellum-dependent cell motility (GO:0001539)2.13769192
127cilium movement (GO:0003341)2.13631017
128nucleobase catabolic process (GO:0046113)2.13398024
129axon extension (GO:0048675)2.12890984
130Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.12616363
131regulation of axon extension involved in axon guidance (GO:0048841)2.11441975
132regulation of establishment of planar polarity (GO:0090175)2.07476761
133mechanosensory behavior (GO:0007638)2.05434687
134negative regulation of axonogenesis (GO:0050771)2.04885101
135spinal cord development (GO:0021510)2.04705864
136nonmotile primary cilium assembly (GO:0035058)2.04544175
137axoneme assembly (GO:0035082)2.04475308
138synapsis (GO:0007129)2.02747274
139response to auditory stimulus (GO:0010996)2.02564117
140biotin metabolic process (GO:0006768)2.02165310
141positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.01932126
142epithelial cell fate commitment (GO:0072148)2.00928651
143positive regulation of dendritic spine morphogenesis (GO:0061003)2.00673595
144chromosome organization involved in meiosis (GO:0070192)2.00669660
145urinary tract smooth muscle contraction (GO:0014848)1.95900850
146epithelial cilium movement (GO:0003351)1.95847705

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.39476240
2JARID2_20064375_ChIP-Seq_MESCs_Mouse2.88339737
3GBX2_23144817_ChIP-Seq_PC3_Human2.88337964
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.85334591
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.82240497
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.78281535
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.76150968
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.74365723
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.74365723
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.62970365
11EZH2_27294783_Chip-Seq_ESCs_Mouse2.46753723
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.42808494
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.40506081
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.40441840
15SUZ12_27294783_Chip-Seq_ESCs_Mouse2.39681774
16REST_21632747_ChIP-Seq_MESCs_Mouse2.38992522
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.35183603
18DROSHA_22980978_ChIP-Seq_HELA_Human2.33455307
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.33260018
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.32116769
21CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.31086964
22MTF2_20144788_ChIP-Seq_MESCs_Mouse2.30026138
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.28024080
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.25926849
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.16469525
26RARB_27405468_Chip-Seq_BRAIN_Mouse2.15840181
27RBPJ_22232070_ChIP-Seq_NCS_Mouse2.06324536
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.04211690
29REST_18959480_ChIP-ChIP_MESCs_Mouse1.95126824
30STAT6_21828071_ChIP-Seq_BEAS2B_Human1.94452187
31ERG_21242973_ChIP-ChIP_JURKAT_Human1.82184758
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.78043018
33CBX2_27304074_Chip-Seq_ESCs_Mouse1.66468589
34IKZF1_21737484_ChIP-ChIP_HCT116_Human1.64168901
35PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.61628801
36RING1B_27294783_Chip-Seq_ESCs_Mouse1.60730524
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.59826510
38ZNF274_21170338_ChIP-Seq_K562_Hela1.49760845
39MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.46414271
40RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.45469303
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.44997770
42* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.44691820
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.43460301
44RING1B_27294783_Chip-Seq_NPCs_Mouse1.41048630
45AR_21572438_ChIP-Seq_LNCaP_Human1.37320323
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36228956
47SMAD4_21799915_ChIP-Seq_A2780_Human1.26741585
48RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.26072655
49SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.26070358
50OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.24965180
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24916789
52SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.23605554
53KDM2B_26808549_Chip-Seq_K562_Human1.22310357
54TP53_20018659_ChIP-ChIP_R1E_Mouse1.21760798
55WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19457003
56RNF2_27304074_Chip-Seq_NSC_Mouse1.19198475
57* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.18583811
58AR_19668381_ChIP-Seq_PC3_Human1.18188148
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.17494291
60TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15870399
61ARNT_22903824_ChIP-Seq_MCF-7_Human1.14881033
62CTCF_27219007_Chip-Seq_Bcells_Human1.13700046
63TAF15_26573619_Chip-Seq_HEK293_Human1.12932074
64ESR1_20079471_ChIP-ChIP_T-47D_Human1.12834419
65DNAJC2_21179169_ChIP-ChIP_NT2_Human1.11897247
66SOX2_21211035_ChIP-Seq_LN229_Gbm1.10107729
67EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.07935878
68* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.07836383
69AHR_22903824_ChIP-Seq_MCF-7_Human1.06760192
70GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05019284
71* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.04522930
72PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04325089
73RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02392055
74* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01452491
75ESR2_21235772_ChIP-Seq_MCF-7_Human1.00735723
76MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00430086
77YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99359189
78POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99216135
79TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99216135
80SMC4_20622854_ChIP-Seq_HELA_Human0.98614420
81ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98318500
82IGF1R_20145208_ChIP-Seq_DFB_Human0.98008247
83DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.97983207
84CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.97466196
85P300_19829295_ChIP-Seq_ESCs_Human0.97142110
86TET1_21490601_ChIP-Seq_MESCs_Mouse0.96870939
87TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95832723
88ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.95825462
89SMAD3_21741376_ChIP-Seq_ESCs_Human0.95204608
90* ISL1_27105846_Chip-Seq_CPCs_Mouse0.95121689
91NFIB_24661679_ChIP-Seq_LUNG_Mouse0.94661383
92ZFP57_27257070_Chip-Seq_ESCs_Mouse0.93277971
93E2F1_17053090_ChIP-ChIP_MCF-7_Human0.93149509
94GATA1_26923725_Chip-Seq_HPCs_Mouse0.91874302
95* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.91002003
96STAT3_23295773_ChIP-Seq_U87_Human0.90505387
97PIAS1_25552417_ChIP-Seq_VCAP_Human0.90259116
98NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89988283
99TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89876535
100ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.89658183
101SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.89501864
102* SOX3_22085726_ChIP-Seq_NPCs_Mouse0.88824211
103EP300_21415370_ChIP-Seq_HL-1_Mouse0.88183692
104SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.88118158
105NR3C1_23031785_ChIP-Seq_PC12_Mouse0.87877240
106* SMAD4_21741376_ChIP-Seq_HESCs_Human0.87583927
107TCF4_23295773_ChIP-Seq_U87_Human0.87567790
108NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.87523954
109TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87487685
110AR_25329375_ChIP-Seq_VCAP_Human0.85886552
111THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.83810848
112SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83712290
113SMAD3_21741376_ChIP-Seq_HESCs_Human0.82966428
114TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.82449041
115ESR1_21235772_ChIP-Seq_MCF-7_Human0.81481609
116ELK4_26923725_Chip-Seq_MESODERM_Mouse0.81010563
117POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.80069531
118TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.80057526
119SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.80050864
120OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.79962130
121NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.79495482
122SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.77981387
123SOX9_26525672_Chip-Seq_HEART_Mouse0.76794474
124POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.75200328
125ESR1_15608294_ChIP-ChIP_MCF-7_Human0.74502326
126ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.73647222
127SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.73348520

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.74589887
2MP0003880_abnormal_central_pattern3.48938064
3MP0003635_abnormal_synaptic_transmissio3.12350859
4MP0005423_abnormal_somatic_nervous2.77360978
5MP0004270_analgesia2.64893621
6MP0009745_abnormal_behavioral_response2.55172443
7MP0002063_abnormal_learning/memory/cond2.44508723
8MP0002064_seizures2.42563725
9MP0001486_abnormal_startle_reflex2.39356933
10MP0009046_muscle_twitch2.35033521
11MP0002572_abnormal_emotion/affect_behav2.11494194
12MP0000778_abnormal_nervous_system2.10150242
13MP0002272_abnormal_nervous_system2.03758851
14MP0003122_maternal_imprinting2.00973582
15MP0001968_abnormal_touch/_nociception1.94329815
16MP0002734_abnormal_mechanical_nocicepti1.90432552
17MP0004133_heterotaxia1.90131647
18MP0004145_abnormal_muscle_electrophysio1.78225449
19MP0001440_abnormal_grooming_behavior1.77239595
20MP0002733_abnormal_thermal_nociception1.75209269
21MP0000751_myopathy1.74769522
22MP0002184_abnormal_innervation1.74661647
23MP0000566_synostosis1.62006941
24MP0000955_abnormal_spinal_cord1.61266340
25MP0004885_abnormal_endolymph1.59627493
26MP0006276_abnormal_autonomic_nervous1.58368097
27MP0009780_abnormal_chondrocyte_physiolo1.57753399
28MP0002736_abnormal_nociception_after1.55934740
29MP0002557_abnormal_social/conspecific_i1.55448451
30MP0002822_catalepsy1.54419143
31MP0004858_abnormal_nervous_system1.54215512
32MP0002067_abnormal_sensory_capabilities1.53325559
33MP0010030_abnormal_orbit_morphology1.53126278
34MP0001970_abnormal_pain_threshold1.53027436
35MP0002234_abnormal_pharynx_morphology1.48944449
36MP0002882_abnormal_neuron_morphology1.48279069
37MP0002735_abnormal_chemical_nociception1.48267821
38MP0003787_abnormal_imprinting1.47643639
39MP0008569_lethality_at_weaning1.47184454
40MP0002653_abnormal_ependyma_morphology1.44035588
41MP0004811_abnormal_neuron_physiology1.42068134
42MP0006072_abnormal_retinal_apoptosis1.39861418
43MP0005394_taste/olfaction_phenotype1.38982430
44MP0005499_abnormal_olfactory_system1.38982430
45MP0001501_abnormal_sleep_pattern1.38236603
46MP0005645_abnormal_hypothalamus_physiol1.36724509
47MP0001984_abnormal_olfaction1.32455614
48MP0005646_abnormal_pituitary_gland1.32407498
49MP0003137_abnormal_impulse_conducting1.29718716
50MP0002909_abnormal_adrenal_gland1.26795797
51MP0005551_abnormal_eye_electrophysiolog1.26200053
52MP0003283_abnormal_digestive_organ1.26098841
53MP0004924_abnormal_behavior1.22072806
54MP0005386_behavior/neurological_phenoty1.22072806
55MP0002152_abnormal_brain_morphology1.21535277
56MP0002837_dystrophic_cardiac_calcinosis1.21456526
57MP0000631_abnormal_neuroendocrine_gland1.21149844
58MP0005623_abnormal_meninges_morphology1.21061371
59MP0002066_abnormal_motor_capabilities/c1.18594813
60MP0004142_abnormal_muscle_tone1.18163753
61MP0005410_abnormal_fertilization1.16264534
62MP0004085_abnormal_heartbeat1.15888772
63MP0008789_abnormal_olfactory_epithelium1.12908378
64MP0000516_abnormal_urinary_system1.12077234
65MP0005367_renal/urinary_system_phenotyp1.12077234
66MP0000579_abnormal_nail_morphology1.10709324
67MP0002638_abnormal_pupillary_reflex1.10479051
68MP0001502_abnormal_circadian_rhythm1.09778453
69MP0002752_abnormal_somatic_nervous1.08647210
70MP0003329_amyloid_beta_deposits1.08536642
71MP0006292_abnormal_olfactory_placode1.07411559
72MP0000749_muscle_degeneration1.07051391
73MP0000049_abnormal_middle_ear1.04320429
74MP0008961_abnormal_basal_metabolism1.03921612
75MP0003861_abnormal_nervous_system1.01420509
76MP0003879_abnormal_hair_cell1.01387952
77MP0000534_abnormal_ureter_morphology1.01267280
78MP0004043_abnormal_pH_regulation1.00450758
79MP0003121_genomic_imprinting1.00285522
80MP0002249_abnormal_larynx_morphology0.98302962
81MP0003119_abnormal_digestive_system0.96456876
82MP0000537_abnormal_urethra_morphology0.95996954
83MP0005253_abnormal_eye_physiology0.94647751
84MP0003937_abnormal_limbs/digits/tail_de0.94052725
85MP0003136_yellow_coat_color0.93867947
86MP0002233_abnormal_nose_morphology0.89086637
87MP0003942_abnormal_urinary_system0.88987847
88MP0010368_abnormal_lymphatic_system0.88700672
89MP0002229_neurodegeneration0.88554860
90MP0000750_abnormal_muscle_regeneration0.86692453
91MP0002108_abnormal_muscle_morphology0.85887860
92MP0002069_abnormal_eating/drinking_beha0.85794663
93MP0004233_abnormal_muscle_weight0.84812562
94MP0001529_abnormal_vocalization0.83615534
95MP0003634_abnormal_glial_cell0.82958671
96MP0001905_abnormal_dopamine_level0.82888065
97MP0001485_abnormal_pinna_reflex0.82546273
98MP0002106_abnormal_muscle_physiology0.82459295
99MP0002116_abnormal_craniofacial_bone0.81970758
100MP0004215_abnormal_myocardial_fiber0.81916022
101MP0005369_muscle_phenotype0.81134580
102MP0001963_abnormal_hearing_physiology0.80820125
103MP0001299_abnormal_eye_distance/0.80162789
104MP0009384_cardiac_valve_regurgitation0.80035986
105MP0004087_abnormal_muscle_fiber0.79669920
106MP0003633_abnormal_nervous_system0.77979508
107MP0000733_abnormal_muscle_development0.77517057
108MP0008877_abnormal_DNA_methylation0.77239170
109MP0002697_abnormal_eye_size0.77031013
110MP0003755_abnormal_palate_morphology0.76837053
111MP0003123_paternal_imprinting0.76367818
112MP0003385_abnormal_body_wall0.76314053
113MP0000003_abnormal_adipose_tissue0.76260401
114MP0003698_abnormal_male_reproductive0.74722508
115MP0000026_abnormal_inner_ear0.74537888
116MP0000678_abnormal_parathyroid_gland0.74372008
117MP0001270_distended_abdomen0.74178252
118MP0001346_abnormal_lacrimal_gland0.71591078
119MP0003631_nervous_system_phenotype0.71104146
120MP0005248_abnormal_Harderian_gland0.70811394
121MP0004742_abnormal_vestibular_system0.70717571
122MP0000013_abnormal_adipose_tissue0.70476564
123MP0003938_abnormal_ear_development0.69788335
124MP0001943_abnormal_respiration0.68577208

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.33798481
2Myokymia (HP:0002411)4.22670624
3Focal seizures (HP:0007359)4.03854166
4Visual hallucinations (HP:0002367)3.24876288
5Epileptic encephalopathy (HP:0200134)3.15301447
6Amblyopia (HP:0000646)3.01415827
7Abnormality of the lower motor neuron (HP:0002366)3.00611194
8Progressive cerebellar ataxia (HP:0002073)2.93187017
9Febrile seizures (HP:0002373)2.92668429
10Hand muscle atrophy (HP:0009130)2.75636239
11Atonic seizures (HP:0010819)2.71761954
12Broad distal phalanx of finger (HP:0009836)2.70233477
13Ankle clonus (HP:0011448)2.58354543
14Dynein arm defect of respiratory motile cilia (HP:0012255)2.56894997
15Absent/shortened dynein arms (HP:0200106)2.56894997
16Supranuclear gaze palsy (HP:0000605)2.54276061
17Hemiparesis (HP:0001269)2.52993592
18Generalized tonic-clonic seizures (HP:0002069)2.52248515
19Absence seizures (HP:0002121)2.45815193
20Action tremor (HP:0002345)2.44221307
21Upper limb amyotrophy (HP:0009129)2.39901404
22Distal upper limb amyotrophy (HP:0007149)2.39901404
23Broad-based gait (HP:0002136)2.38679292
24Dysdiadochokinesis (HP:0002075)2.37199427
25Dialeptic seizures (HP:0011146)2.34567407
26Excessive salivation (HP:0003781)2.30517407
27Drooling (HP:0002307)2.30517407
28Insomnia (HP:0100785)2.28789863
29Large eyes (HP:0001090)2.27320962
30Polyphagia (HP:0002591)2.22334474
31Rimmed vacuoles (HP:0003805)2.22063943
32Impaired vibration sensation in the lower limbs (HP:0002166)2.21065536
33Urinary bladder sphincter dysfunction (HP:0002839)2.15973120
34Cutaneous finger syndactyly (HP:0010554)2.13811665
35Exercise-induced muscle cramps (HP:0003710)2.13042328
36Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.12823995
37Truncal ataxia (HP:0002078)2.11440364
38Ependymoma (HP:0002888)2.11294972
39Gaze-evoked nystagmus (HP:0000640)2.10302644
40Hyperventilation (HP:0002883)2.07545819
41Nephronophthisis (HP:0000090)2.05561878
42Depression (HP:0000716)2.04835542
43Occipital encephalocele (HP:0002085)2.03626311
44Failure to thrive in infancy (HP:0001531)2.02875644
45Myopathic facies (HP:0002058)2.02815231
46Prolonged QT interval (HP:0001657)1.98882197
47Abnormal eating behavior (HP:0100738)1.97600654
48Anxiety (HP:0000739)1.96245659
49Megalencephaly (HP:0001355)1.95476511
50Ventricular fibrillation (HP:0001663)1.95375846
51Hyperacusis (HP:0010780)1.92644597
52Poor eye contact (HP:0000817)1.92383967
53Dysmetria (HP:0001310)1.91422373
54Spastic gait (HP:0002064)1.91395846
55Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.90768000
56Genetic anticipation (HP:0003743)1.90590699
57Myoglobinuria (HP:0002913)1.90135363
58Abnormality of the corticospinal tract (HP:0002492)1.88712693
59Bell-shaped thorax (HP:0001591)1.87716965
60Hypoplastic ischia (HP:0003175)1.86222120
61Abnormal EKG (HP:0003115)1.83219316
62Abnormal respiratory motile cilium physiology (HP:0012261)1.82476392
63Generalized hypotonia (HP:0001290)1.81702876
64Morphological abnormality of the middle ear (HP:0008609)1.81172583
65Hypoventilation (HP:0002791)1.80423737
66Abnormal social behavior (HP:0012433)1.79678990
67Impaired social interactions (HP:0000735)1.79678990
68Akinesia (HP:0002304)1.79183858
69Lower limb muscle weakness (HP:0007340)1.79147889
70Tubulointerstitial nephritis (HP:0001970)1.79066422
71Absent speech (HP:0001344)1.78908374
72Neoplasm of the heart (HP:0100544)1.78745412
73Abnormality of the ischium (HP:0003174)1.78672540
74Cutaneous syndactyly (HP:0012725)1.77658110
75Cerebral inclusion bodies (HP:0100314)1.77201312
76Exercise-induced myalgia (HP:0003738)1.76921725
77Congenital glaucoma (HP:0001087)1.76638582
78Limb dystonia (HP:0002451)1.76138169
79Epileptiform EEG discharges (HP:0011182)1.75242403
80Renal duplication (HP:0000075)1.75122071
81Bowel incontinence (HP:0002607)1.74894909
82Bronchomalacia (HP:0002780)1.74836876
83EEG with generalized epileptiform discharges (HP:0011198)1.74065442
84Neurofibrillary tangles (HP:0002185)1.73336630
85Aplasia of the phalanges of the hand (HP:0009802)1.73255496
86Aplasia involving bones of the extremities (HP:0009825)1.73255496
87Aplasia involving bones of the upper limbs (HP:0009823)1.73255496
88Abnormality of the renal medulla (HP:0100957)1.72008433
89Astrocytoma (HP:0009592)1.71201604
90Abnormality of the astrocytes (HP:0100707)1.71201604
91Peripheral hypomyelination (HP:0007182)1.71180592
92Overriding aorta (HP:0002623)1.71063321
93Abnormal ciliary motility (HP:0012262)1.70113880
94Sudden death (HP:0001699)1.69623293
95Abnormal respiratory epithelium morphology (HP:0012253)1.69238117
96Abnormal respiratory motile cilium morphology (HP:0005938)1.69238117
97Elfin facies (HP:0004428)1.69217361
98Turricephaly (HP:0000262)1.68548578
99Medial flaring of the eyebrow (HP:0010747)1.68235700
100Mutism (HP:0002300)1.67694475
101Hypsarrhythmia (HP:0002521)1.67558274
102Abnormality of the musculature of the hand (HP:0001421)1.66684026
103Pheochromocytoma (HP:0002666)1.66023643
104Urinary urgency (HP:0000012)1.65097575
105Abnormality of the calf musculature (HP:0001430)1.63759073
106Congenital primary aphakia (HP:0007707)1.63716986
107Sleep apnea (HP:0010535)1.61644197
108Postural instability (HP:0002172)1.61382710
109Hemiplegia (HP:0002301)1.60704431
110Impaired vibratory sensation (HP:0002495)1.60693585
111Vaginal atresia (HP:0000148)1.60515784
112Genital tract atresia (HP:0001827)1.59743711
113Abnormality of the aortic arch (HP:0012303)1.59232129
114Cholecystitis (HP:0001082)1.59168267
115Abnormal gallbladder physiology (HP:0012438)1.59168267
116Hypoplasia of the brainstem (HP:0002365)1.59145684
117Aplasia/Hypoplasia of the brainstem (HP:0007362)1.59145684
118Renovascular hypertension (HP:0100817)1.59128156
119Chronic hepatic failure (HP:0100626)1.58845768
120Agitation (HP:0000713)1.57940178
121Hammertoe (HP:0001765)1.57872840
122Stridor (HP:0010307)1.57523663
123Fetal akinesia sequence (HP:0001989)1.56498602
124Specific learning disability (HP:0001328)1.56445117
125Gout (HP:0001997)1.56435933
126Alacrima (HP:0000522)1.56301366
127Bifid tongue (HP:0010297)1.56158419
128Gait imbalance (HP:0002141)1.55211675
129Narrow nasal bridge (HP:0000446)1.55083862
130Retinal dysplasia (HP:0007973)1.54982539
131Type 1 muscle fiber predominance (HP:0003803)1.54894398
132Rapidly progressive (HP:0003678)1.54296971
133Difficulty climbing stairs (HP:0003551)1.52705081
134Upper limb muscle weakness (HP:0003484)1.51893133
135Shoulder girdle muscle weakness (HP:0003547)1.51058517
136Lymphangioma (HP:0100764)1.50871788
137Renal hypoplasia (HP:0000089)1.50515853
138Abnormality of dentin (HP:0010299)1.50148860
139Obstructive sleep apnea (HP:0002870)1.49694862
140Myotonia (HP:0002486)1.48343363
141Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.47371990
142Nephrogenic diabetes insipidus (HP:0009806)1.44806242
143Hyperinsulinemic hypoglycemia (HP:0000825)1.44513843
144Absent epiphyses (HP:0010577)1.42911739
145Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.42911739
146Hypoglycemic coma (HP:0001325)1.42710471
147Muscle fiber inclusion bodies (HP:0100299)1.42134175
148Hypoplasia of the iris (HP:0007676)1.40306162
149Hepatoblastoma (HP:0002884)1.39989192
150Abnormality of midbrain morphology (HP:0002418)1.39884358
151Molar tooth sign on MRI (HP:0002419)1.39884358
152Bundle branch block (HP:0011710)1.39696228
153Abnormality of permanent molar morphology (HP:0011071)1.39466949
154Abnormality of the dental root (HP:0006486)1.39466949
155Taurodontia (HP:0000679)1.39466949
156Degeneration of the lateral corticospinal tracts (HP:0002314)1.37562864
157Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.37562864
158Abnormality of the labia (HP:0000058)1.36842282
159Limb-girdle muscle weakness (HP:0003325)1.35950700

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.26201926
2MARK13.16111974
3MAP3K42.91524586
4EPHA42.81502081
5MAP3K92.56332972
6PRPF4B2.20392414
7MAP2K72.09990208
8MINK12.05768972
9PRKD32.04938570
10DAPK22.03697528
11NTRK21.98454456
12PAK61.97935874
13PHKG11.86114261
14PHKG21.86114261
15MAP2K41.76535007
16MAPK131.76256296
17CASK1.68386859
18PNCK1.62642674
19MAP3K21.53158831
20ICK1.49529352
21UHMK11.46392320
22SIK21.43079550
23PTK2B1.42113058
24BRD41.38669357
25MET1.36453444
26EPHA21.32274137
27CDK51.30767177
28TYRO31.27459646
29WNK41.26201823
30FRK1.20151897
31CAMK1G1.19629191
32NTRK11.19546801
33MUSK1.19372753
34ERBB21.17746616
35KSR11.15293197
36TNIK1.13646954
37PAK31.12207603
38LMTK21.11144924
39CDC42BPA1.07895472
40KSR21.05707947
41CAMKK11.05169665
42SGK2231.04932332
43SGK4941.04932332
44STK391.04810717
45STK110.98742561
46SIK10.95631193
47GRK50.94719940
48RPS6KA20.93574017
49PTK20.93564337
50TNK20.93456446
51STK380.93160719
52PRKD20.92002379
53PRKCG0.91898368
54WNK30.91020521
55WNK10.90709762
56PLK20.90107209
57DYRK1A0.89785675
58MARK20.88399739
59CAMK2A0.86971924
60FER0.85610441
61DAPK10.85397620
62CAMK10.85337300
63TAOK10.82408983
64TRIB30.81573626
65PRKCE0.81165220
66TTN0.80204105
67EPHB20.79418437
68CDK190.77811833
69EPHA30.76265045
70CAMK2G0.76015986
71PRKAA10.75572869
72CAMK40.74335396
73EEF2K0.73145891
74TESK10.72852041
75MAPK150.72354419
76OXSR10.72090547
77PRKCZ0.71190710
78CDK150.70979436
79MST1R0.70893459
80PDGFRA0.70310958
81CDK180.70072716
82CAMK2B0.68340658
83DYRK20.67691534
84MAPKAPK30.67640515
85SGK10.66604953
86LATS20.66058283
87FES0.64788569
88BCR0.64473592
89CDK11A0.62396977
90DDR20.61261711
91CDK140.60542252
92PRKCI0.59617575
93PRKCH0.59201572
94ERBB30.58666565
95CSNK1G30.57525017
96RPS6KA30.56704111
97RIPK10.55997607
98CAMK1D0.55645322
99ROCK10.55489829
100PDK40.55031809
101PDK30.55031809
102FGFR20.54789918
103STK38L0.54436853
104CSNK1G10.52955818
105ROCK20.52782722
106NME10.52685659
107CSNK1G20.52654555
108CAMK2D0.52264927
109SGK30.51692276
110FGR0.51578133
111MAP3K70.51389139
112MAPK100.50932047
113OBSCN0.49865430
114LIMK10.49004538
115RET0.48897544
116SGK20.46998400
117AKT30.46479222
118PRKDC0.46456018
119MAPKAPK50.46161497
120PKN10.46027461
121PINK10.45978380
122NEK60.45477690
123PDGFRB0.45317747
124ADRBK10.45130199
125BMX0.44938575
126MAP4K20.44282479
127INSRR0.43048530
128MAP2K60.42590264
129CSNK1E0.42552027
130MTOR0.40218708

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.23191020
2Synaptic vesicle cycle_Homo sapiens_hsa047212.63705642
3Circadian entrainment_Homo sapiens_hsa047132.50744440
4Glutamatergic synapse_Homo sapiens_hsa047242.41622168
5GABAergic synapse_Homo sapiens_hsa047272.41253467
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.32603501
7Olfactory transduction_Homo sapiens_hsa047402.25805882
8Amphetamine addiction_Homo sapiens_hsa050312.17398290
9Morphine addiction_Homo sapiens_hsa050322.16594658
10Long-term potentiation_Homo sapiens_hsa047202.13450260
11Insulin secretion_Homo sapiens_hsa049112.10504454
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.98346564
13Dopaminergic synapse_Homo sapiens_hsa047281.93254020
14Taste transduction_Homo sapiens_hsa047421.88216941
15Salivary secretion_Homo sapiens_hsa049701.83031487
16Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.72132424
17Gastric acid secretion_Homo sapiens_hsa049711.72119203
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.71993942
19Axon guidance_Homo sapiens_hsa043601.70569604
20Cholinergic synapse_Homo sapiens_hsa047251.66827645
21Cardiac muscle contraction_Homo sapiens_hsa042601.65793620
22Cocaine addiction_Homo sapiens_hsa050301.65043201
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.55593380
24Renin secretion_Homo sapiens_hsa049241.55583989
25Phototransduction_Homo sapiens_hsa047441.52329926
26Oxytocin signaling pathway_Homo sapiens_hsa049211.51394568
27Serotonergic synapse_Homo sapiens_hsa047261.49841037
28Type II diabetes mellitus_Homo sapiens_hsa049301.48180392
29Calcium signaling pathway_Homo sapiens_hsa040201.46485841
30Long-term depression_Homo sapiens_hsa047301.45460997
31Gap junction_Homo sapiens_hsa045401.44947732
32Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.44232280
33GnRH signaling pathway_Homo sapiens_hsa049121.35902103
34Steroid biosynthesis_Homo sapiens_hsa001001.28899753
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.26020295
36Dilated cardiomyopathy_Homo sapiens_hsa054141.25369186
37cAMP signaling pathway_Homo sapiens_hsa040241.20819547
38Fatty acid elongation_Homo sapiens_hsa000621.17417576
39Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.16980437
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.16306840
41Butanoate metabolism_Homo sapiens_hsa006501.14423900
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.11559331
43Melanogenesis_Homo sapiens_hsa049161.10811264
44Dorso-ventral axis formation_Homo sapiens_hsa043201.10693882
45Estrogen signaling pathway_Homo sapiens_hsa049151.10536075
46cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08971848
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08872929
48Lysine degradation_Homo sapiens_hsa003101.06973615
49Phenylalanine metabolism_Homo sapiens_hsa003601.06866066
50Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.04671232
51Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.03535663
52ErbB signaling pathway_Homo sapiens_hsa040121.02727174
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.01547913
54beta-Alanine metabolism_Homo sapiens_hsa004101.00973345
55Vascular smooth muscle contraction_Homo sapiens_hsa042701.00398030
56Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.99626567
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.99035864
58Arginine and proline metabolism_Homo sapiens_hsa003300.97520081
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.97353443
60Collecting duct acid secretion_Homo sapiens_hsa049660.95843272
61Hedgehog signaling pathway_Homo sapiens_hsa043400.92091913
62Glucagon signaling pathway_Homo sapiens_hsa049220.91971672
63Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.90499863
64Fatty acid metabolism_Homo sapiens_hsa012120.89226672
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.88258765
66Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.87891786
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86608711
68Pyruvate metabolism_Homo sapiens_hsa006200.85936597
69Glioma_Homo sapiens_hsa052140.85681589
70Propanoate metabolism_Homo sapiens_hsa006400.84999050
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.84508267
72Pancreatic secretion_Homo sapiens_hsa049720.83205809
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81509384
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.79205731
75Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.79200042
76Wnt signaling pathway_Homo sapiens_hsa043100.78873968
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75808543
78Basal cell carcinoma_Homo sapiens_hsa052170.73225852
79Huntingtons disease_Homo sapiens_hsa050160.68305829
80Thyroid hormone synthesis_Homo sapiens_hsa049180.67855888
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67593179
82Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.67522682
83MAPK signaling pathway_Homo sapiens_hsa040100.67120657
84Vibrio cholerae infection_Homo sapiens_hsa051100.65843237
85Alcoholism_Homo sapiens_hsa050340.65828037
86Glycosaminoglycan degradation_Homo sapiens_hsa005310.65335699
87Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.65289855
88Fructose and mannose metabolism_Homo sapiens_hsa000510.64804301
89Choline metabolism in cancer_Homo sapiens_hsa052310.64331639
90Fatty acid biosynthesis_Homo sapiens_hsa000610.63398409
91Biosynthesis of amino acids_Homo sapiens_hsa012300.62324474
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61999933
93Insulin signaling pathway_Homo sapiens_hsa049100.61977196
94Regulation of autophagy_Homo sapiens_hsa041400.61181715
95Histidine metabolism_Homo sapiens_hsa003400.60813797
96Tight junction_Homo sapiens_hsa045300.60666769
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60574726
98Ras signaling pathway_Homo sapiens_hsa040140.59649023
99mTOR signaling pathway_Homo sapiens_hsa041500.59153535
100Adherens junction_Homo sapiens_hsa045200.59109293
101Oocyte meiosis_Homo sapiens_hsa041140.58824649
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56224389
103Circadian rhythm_Homo sapiens_hsa047100.55140203
104Carbon metabolism_Homo sapiens_hsa012000.54943943
105mRNA surveillance pathway_Homo sapiens_hsa030150.54851666
106Alzheimers disease_Homo sapiens_hsa050100.54793782
107Bile secretion_Homo sapiens_hsa049760.54163810
108Endometrial cancer_Homo sapiens_hsa052130.53751500
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53016919
110ECM-receptor interaction_Homo sapiens_hsa045120.52713773
111Cyanoamino acid metabolism_Homo sapiens_hsa004600.51844418
112Rap1 signaling pathway_Homo sapiens_hsa040150.51730954
113Vitamin B6 metabolism_Homo sapiens_hsa007500.51540703
114Parkinsons disease_Homo sapiens_hsa050120.50380043
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.47953319
116Hippo signaling pathway_Homo sapiens_hsa043900.46993339
117Notch signaling pathway_Homo sapiens_hsa043300.46675303
118Renal cell carcinoma_Homo sapiens_hsa052110.45765199
119Prion diseases_Homo sapiens_hsa050200.42649650
120Ovarian steroidogenesis_Homo sapiens_hsa049130.39030314
121Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.38497853
122Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38216476
123Neurotrophin signaling pathway_Homo sapiens_hsa047220.37125963
124Glycerophospholipid metabolism_Homo sapiens_hsa005640.36186983
125Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.35889968
126AMPK signaling pathway_Homo sapiens_hsa041520.35699166
127Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35384902
128VEGF signaling pathway_Homo sapiens_hsa043700.35137825
129Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34816036
130Inositol phosphate metabolism_Homo sapiens_hsa005620.32926564
131Oxidative phosphorylation_Homo sapiens_hsa001900.32631597
132Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31861981
133Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.30927234

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