PRPF6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene appears to be involved in pre-mRNA splicing, possibly acting as a bridging factor between U5 and U4/U6 snRNPs in formation of the spliceosome. The encoded protein also can bind androgen receptor, providing a link between transcriptional activation and splicing. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1folic acid-containing compound biosynthetic process (GO:0009396)5.00998581
2retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.61007636
3regulation of translational fidelity (GO:0006450)4.39206277
4* spliceosomal tri-snRNP complex assembly (GO:0000244)4.28000655
5mitotic nuclear envelope disassembly (GO:0007077)4.19598168
6paraxial mesoderm development (GO:0048339)4.06281605
7nuclear envelope disassembly (GO:0051081)3.96841097
8membrane disassembly (GO:0030397)3.96841097
9formation of translation preinitiation complex (GO:0001731)3.89965570
10pentose-phosphate shunt (GO:0006098)3.88442836
11regulation of mammary gland epithelial cell proliferation (GO:0033599)3.88198691
12IMP biosynthetic process (GO:0006188)3.88183740
13nuclear pore organization (GO:0006999)3.87925721
14DNA unwinding involved in DNA replication (GO:0006268)3.87004778
15histone H2A ubiquitination (GO:0033522)3.80981473
16histone H2A monoubiquitination (GO:0035518)3.78389484
17regulation of posttranscriptional gene silencing (GO:0060147)3.73127783
18regulation of gene silencing by miRNA (GO:0060964)3.73127783
19regulation of gene silencing by RNA (GO:0060966)3.73127783
20maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.72352682
21protein retention in ER lumen (GO:0006621)3.68816715
22regulation of nucleobase-containing compound transport (GO:0032239)3.62986313
23nuclear pore complex assembly (GO:0051292)3.55517205
24glucose catabolic process (GO:0006007)3.52685090
25regulation of mitotic spindle organization (GO:0060236)3.52065329
26nucleobase biosynthetic process (GO:0046112)3.51920161
27protein localization to kinetochore (GO:0034501)3.48407039
28regulation of spindle organization (GO:0090224)3.46713494
29negative regulation of histone methylation (GO:0031061)3.43931306
30negative regulation of cell size (GO:0045792)3.42337375
31proline metabolic process (GO:0006560)3.40396106
32NADPH regeneration (GO:0006740)3.38435106
33IMP metabolic process (GO:0046040)3.35421332
34Golgi transport vesicle coating (GO:0048200)3.33912453
35COPI coating of Golgi vesicle (GO:0048205)3.33912453
36activation of Rac GTPase activity (GO:0032863)3.33447104
37cell-substrate adherens junction assembly (GO:0007045)3.30186297
38focal adhesion assembly (GO:0048041)3.30186297
39purine nucleobase biosynthetic process (GO:0009113)3.30010076
40regulation of histone H3-K27 methylation (GO:0061085)3.28980190
41folic acid metabolic process (GO:0046655)3.28293652
42peptidyl-arginine omega-N-methylation (GO:0035247)3.27005089
43glucose 6-phosphate metabolic process (GO:0051156)3.26802659
44heterochromatin organization (GO:0070828)3.26220039
45activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.23050372
463-UTR-mediated mRNA stabilization (GO:0070935)3.21324057
47dosage compensation (GO:0007549)3.21204277
48regulation of glucose import in response to insulin stimulus (GO:2001273)3.20926526
49adherens junction assembly (GO:0034333)3.20871415
50positive regulation of nuclease activity (GO:0032075)3.18992251
51pre-miRNA processing (GO:0031054)3.18941907
52intracellular estrogen receptor signaling pathway (GO:0030520)3.17450041
53protein maturation by protein folding (GO:0022417)3.15539531
54mitotic chromosome condensation (GO:0007076)3.15400589
55DNA duplex unwinding (GO:0032508)3.15216963
56DNA geometric change (GO:0032392)3.15088322
57nuclear envelope organization (GO:0006998)3.15034006
58negative regulation of chromosome segregation (GO:0051985)3.07307448
59tetrahydrofolate metabolic process (GO:0046653)3.05903700
60mitotic spindle assembly checkpoint (GO:0007094)3.04101946
61mitotic sister chromatid segregation (GO:0000070)3.03002000
62negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.01927442
63negative regulation of mitotic sister chromatid separation (GO:2000816)2.99932910
64negative regulation of mitotic sister chromatid segregation (GO:0033048)2.99932910
65negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.99932910
66negative regulation of sister chromatid segregation (GO:0033046)2.99932910
67translesion synthesis (GO:0019985)2.99526802
68DNA replication-dependent nucleosome organization (GO:0034723)2.99144599
69DNA replication-dependent nucleosome assembly (GO:0006335)2.99144599
70positive regulation of Cdc42 GTPase activity (GO:0043089)2.99006561
71negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.98135576
72spindle assembly checkpoint (GO:0071173)2.97466076
73protein-DNA complex disassembly (GO:0032986)2.96804261
74nucleosome disassembly (GO:0006337)2.96804261
75protein localization to endosome (GO:0036010)2.95814833
76sister chromatid segregation (GO:0000819)2.95541528
77mRNA stabilization (GO:0048255)2.92322975
78RNA stabilization (GO:0043489)2.92322975
79glycine metabolic process (GO:0006544)2.91312596
80regulation of RNA export from nucleus (GO:0046831)2.90324878
81mitotic spindle checkpoint (GO:0071174)2.90293646
82NADH metabolic process (GO:0006734)2.89720653
83endoplasmic reticulum unfolded protein response (GO:0030968)2.89657026
84snRNA metabolic process (GO:0016073)2.89217622
85apoptotic process involved in morphogenesis (GO:0060561)2.87897116
86regulation of nuclease activity (GO:0032069)2.86775345
87pteridine-containing compound biosynthetic process (GO:0042559)2.86714893
88positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.86484144
89postreplication repair (GO:0006301)2.85654466
90maturation of SSU-rRNA (GO:0030490)2.85412286
91pinocytosis (GO:0006907)2.84441596
92chaperone-mediated protein complex assembly (GO:0051131)2.83251498
93mitotic metaphase plate congression (GO:0007080)2.82127949
94GDP-mannose metabolic process (GO:0019673)2.79842282
95regulation of cholesterol biosynthetic process (GO:0045540)2.79748526
96regulation of mitotic metaphase/anaphase transition (GO:0030071)2.79477843
97ER-nucleus signaling pathway (GO:0006984)2.78750085
98regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.78553882
99epithelial cell differentiation involved in prostate gland development (GO:0060742)2.77612076
100regulation of histone H3-K9 methylation (GO:0051570)2.76673586
101maternal placenta development (GO:0001893)2.75622423
102negative regulation of DNA-templated transcription, elongation (GO:0032785)2.75475949
103protein export from nucleus (GO:0006611)2.75403631
104negative regulation of viral release from host cell (GO:1902187)2.74365702
105histone arginine methylation (GO:0034969)2.73999732
106DNA strand elongation involved in DNA replication (GO:0006271)2.73132567
107spindle checkpoint (GO:0031577)2.72930749
108DNA replication initiation (GO:0006270)2.72594003
109chromatin assembly (GO:0031497)2.71088253
110regulation of cholesterol homeostasis (GO:2000188)2.70530110
111regulation of translational elongation (GO:0006448)2.69611316
112modulation by virus of host process (GO:0019054)2.69506400
113mitochondrial fusion (GO:0008053)2.69247141
114glycolytic process (GO:0006096)2.69190559
115folic acid-containing compound metabolic process (GO:0006760)2.67344305
116modulation by symbiont of host cellular process (GO:0044068)2.66960234
117peptidyl-arginine methylation (GO:0018216)2.66622373
118peptidyl-arginine N-methylation (GO:0035246)2.66622373
119activation of MAPKKK activity (GO:0000185)2.66489865
120positive regulation of SMAD protein import into nucleus (GO:0060391)2.66483507
121regulation of chromosome segregation (GO:0051983)2.65868489
122cellular response to unfolded protein (GO:0034620)2.65251184
123lysine metabolic process (GO:0006553)2.65150355
124lysine catabolic process (GO:0006554)2.65150355
125barbed-end actin filament capping (GO:0051016)2.64524380
126cellular response to epidermal growth factor stimulus (GO:0071364)2.63546934
127vesicle coating (GO:0006901)2.63146991
128somatic hypermutation of immunoglobulin genes (GO:0016446)2.63111432
129somatic diversification of immune receptors via somatic mutation (GO:0002566)2.63111432
130regulation of chromatin binding (GO:0035561)2.63103477
131anterior/posterior axis specification, embryo (GO:0008595)2.62889665
132regulation of sister chromatid segregation (GO:0033045)2.62804407
133regulation of mitotic sister chromatid separation (GO:0010965)2.62804407
134regulation of mitotic sister chromatid segregation (GO:0033047)2.62804407
135regulation of translational termination (GO:0006449)2.62663157
136DNA strand elongation (GO:0022616)2.62409733
137regulation of sister chromatid cohesion (GO:0007063)2.61132075
138modulation by virus of host morphology or physiology (GO:0019048)2.58035974
139cellular hyperosmotic response (GO:0071474)2.57225985
140cytoskeletal anchoring at plasma membrane (GO:0007016)2.56483984
141negative regulation of translational initiation (GO:0045947)2.56323914
142regulation of superoxide anion generation (GO:0032928)2.56004373
143negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.55932575
144cellular response to interleukin-4 (GO:0071353)2.55753758
145cell-substrate junction assembly (GO:0007044)2.55230226
146oxidative demethylation (GO:0070989)2.53462571
147negative regulation of mRNA processing (GO:0050686)2.52473018
148regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.51669831
149positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.51669831
150mRNA transport (GO:0051028)2.51297010
151negative regulation of gene silencing (GO:0060969)2.50731899
152protein localization to chromosome, centromeric region (GO:0071459)2.50284801
153oxaloacetate metabolic process (GO:0006107)2.50199136
154positive regulation of keratinocyte differentiation (GO:0045618)2.50025232
155mitotic G1 DNA damage checkpoint (GO:0031571)2.50010720
156endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.49751842
157cellular response to topologically incorrect protein (GO:0035967)2.49046672
158snRNA processing (GO:0016180)2.48902076
159regulation of translational initiation (GO:0006446)2.48272751
160pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.46981578
161UMP metabolic process (GO:0046049)2.46981578
162pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.46981578
163UMP biosynthetic process (GO:0006222)2.46981578
164* spliceosomal snRNP assembly (GO:0000387)2.46217761
165metaphase plate congression (GO:0051310)2.45991498
166NIK/NF-kappaB signaling (GO:0038061)2.44715992
167proline biosynthetic process (GO:0006561)2.43649031
168nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.43212820
169pore complex assembly (GO:0046931)2.42961764
170monosaccharide biosynthetic process (GO:0046364)2.42874764
171DNA topological change (GO:0006265)2.42817053
172nuclear envelope reassembly (GO:0031468)2.42769421
173mitotic nuclear envelope reassembly (GO:0007084)2.42769421
174negative regulation of mRNA metabolic process (GO:1903312)2.42274387
175rRNA transcription (GO:0009303)2.41653988
176regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.41272396
177mannose metabolic process (GO:0006013)2.39978077
178protein insertion into membrane (GO:0051205)2.38523448

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.39869655
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.89348773
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.53879870
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.29417334
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.26152182
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.78546157
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.66794128
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.43543658
9ZNF263_19887448_ChIP-Seq_K562_Human2.42922820
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.40816359
11* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.31399393
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.30737789
13MYC_22102868_ChIP-Seq_BL_Human2.20784213
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.19812276
15LXR_22292898_ChIP-Seq_THP-1_Human2.12953371
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.07888150
17* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.04915807
18POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.03508476
19XRN2_22483619_ChIP-Seq_HELA_Human2.03084504
20KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.98947111
21ELK3_25401928_ChIP-Seq_HUVEC_Human1.94748574
22* ETS1_20019798_ChIP-Seq_JURKAT_Human1.91396301
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.90054977
24EGR1_19374776_ChIP-ChIP_THP-1_Human1.89632274
25CIITA_25753668_ChIP-Seq_RAJI_Human1.87377364
26ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.87039093
27RACK7_27058665_Chip-Seq_MCF-7_Human1.86371301
28AR_21909140_ChIP-Seq_LNCAP_Human1.85183878
29CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.83750856
30KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.81722579
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.80092736
32POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.75748907
33NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.75482315
34* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.75306312
35E2F1_18555785_ChIP-Seq_MESCs_Mouse1.75235302
36GABP_17652178_ChIP-ChIP_JURKAT_Human1.72368094
37CREB1_15753290_ChIP-ChIP_HEK293T_Human1.71966124
38NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.71386592
39HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.68442256
40KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.67767804
41TCF7_22412390_ChIP-Seq_EML_Mouse1.67091159
42E2F1_21310950_ChIP-Seq_MCF-7_Human1.64998699
43* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.64637768
44STAT3_1855785_ChIP-Seq_MESCs_Mouse1.64016032
45RARG_19884340_ChIP-ChIP_MEFs_Mouse1.63493254
46KDM2B_26808549_Chip-Seq_SUP-B15_Human1.63041261
47NANOG_18555785_ChIP-Seq_MESCs_Mouse1.61085382
48TFEB_21752829_ChIP-Seq_HELA_Human1.60816005
49ZFX_18555785_ChIP-Seq_MESCs_Mouse1.60745151
50PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60508678
51* GABP_19822575_ChIP-Seq_HepG2_Human1.56921284
52MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.56487659
53STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.56339435
54CLOCK_20551151_ChIP-Seq_293T_Human1.55893595
55* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.53586512
56KDM5A_27292631_Chip-Seq_BREAST_Human1.52810976
57NANOG_21062744_ChIP-ChIP_HESCs_Human1.51518404
58FOXP3_21729870_ChIP-Seq_TREG_Human1.49292392
59SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.48219774
60ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.47622297
61PPARA_22158963_ChIP-Seq_LIVER_Mouse1.46088394
62YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44760687
63KDM2B_26808549_Chip-Seq_DND41_Human1.44699085
64RBPJ_22232070_ChIP-Seq_NCS_Mouse1.43529923
65DCP1A_22483619_ChIP-Seq_HELA_Human1.42444810
66* VDR_23849224_ChIP-Seq_CD4+_Human1.42040872
67EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41922361
68TET1_21451524_ChIP-Seq_MESCs_Mouse1.41043439
69CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.40721179
70ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.39846993
71KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.38273647
72KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.38273647
73KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.38273647
74TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35662288
75CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.35543747
76P68_20966046_ChIP-Seq_HELA_Human1.34888078
77THAP11_20581084_ChIP-Seq_MESCs_Mouse1.32337971
78DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.32112693
79ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.32061790
80SALL1_21062744_ChIP-ChIP_HESCs_Human1.31423658
81TCF3_18692474_ChIP-Seq_MEFs_Mouse1.30688970
82MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.30646177
83HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.30565999
84SOX2_18555785_ChIP-Seq_MESCs_Mouse1.30413727
85ESR1_15608294_ChIP-ChIP_MCF-7_Human1.29297629
86KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.27123689
87ELF1_17652178_ChIP-ChIP_JURKAT_Human1.26001016
88POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.24953220
89MAF_26560356_Chip-Seq_TH1_Human1.24850749
90ESR2_21235772_ChIP-Seq_MCF-7_Human1.24678518
91KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.23806319
92KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.23269575
93PADI4_21655091_ChIP-ChIP_MCF-7_Human1.23015884
94KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22080599
95SRY_22984422_ChIP-ChIP_TESTIS_Rat1.21978542
96HIF1A_21447827_ChIP-Seq_MCF-7_Human1.21823814
97RXR_22158963_ChIP-Seq_LIVER_Mouse1.21775139
98YY1_21170310_ChIP-Seq_MESCs_Mouse1.20380939
99SMC4_20622854_ChIP-Seq_HELA_Human1.19870403
100NCOR1_26117541_ChIP-Seq_K562_Human1.17549214
101PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.17242222
102TP63_19390658_ChIP-ChIP_HaCaT_Human1.16998046
103* TTF2_22483619_ChIP-Seq_HELA_Human1.15826534
104SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.14625056
105CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.14504123
106TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13859713
107MAF_26560356_Chip-Seq_TH2_Human1.13835532
108UTX_26944678_Chip-Seq_JUKART_Human1.13507208
109CTCF_27219007_Chip-Seq_ERYTHROID_Human1.13155374
110TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13100861
111* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.11416078
112* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.11318435
113NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.11271118
114UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.10769168
115SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.10139970
116TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.08660199
117SA1_27219007_Chip-Seq_ERYTHROID_Human1.08437132
118SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.08203409
119ELF1_20517297_ChIP-Seq_JURKAT_Human1.08165054
120KDM2B_26808549_Chip-Seq_K562_Human1.08116520
121NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.07866042
122NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.07242381
123KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06612090
124CREB1_26743006_Chip-Seq_LNCaP_Human1.06090026
125HOXB4_20404135_ChIP-ChIP_EML_Mouse1.04893681
126SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.04643344
127ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04433066
128GATA1_22383799_ChIP-Seq_G1ME_Mouse1.04012229
129ELK1_19687146_ChIP-ChIP_HELA_Human1.03290971
130TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.02319730
131PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.02066056
132RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.02017348
133SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01302791
134P300_27058665_Chip-Seq_ZR-75-30cells_Human1.01233334
135PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.00996337
136VDR_24763502_ChIP-Seq_THP-1_Human1.00713100
137RUNX1_27514584_Chip-Seq_MCF-7_Human1.00588227
138RUNX1_22412390_ChIP-Seq_EML_Mouse1.00098374
139SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.99988454
140ZFP281_18757296_ChIP-ChIP_E14_Mouse0.99468103
141TP53_22127205_ChIP-Seq_IMR90_Human0.99418985
142OCT4_18692474_ChIP-Seq_MEFs_Mouse0.98683290
143ATF3_27146783_Chip-Seq_COLON_Human0.98153422
144CHD1_26751641_Chip-Seq_LNCaP_Human0.97369582
145* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95864385
146* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.93875904
147ERG_20887958_ChIP-Seq_HPC-7_Mouse0.93816017
148* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.93341384
149VDR_21846776_ChIP-Seq_THP-1_Human0.93231773
150KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.92412348

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition4.27789690
2MP0008260_abnormal_autophagy3.60352786
3MP0003011_delayed_dark_adaptation3.45575661
4MP0005058_abnormal_lysosome_morphology3.21449532
5MP0003705_abnormal_hypodermis_morpholog3.07461283
6MP0010094_abnormal_chromosome_stability2.88943046
7MP0003806_abnormal_nucleotide_metabolis2.71318654
8MP0003111_abnormal_nucleus_morphology2.64563303
9MP0004957_abnormal_blastocyst_morpholog2.63386723
10MP0003077_abnormal_cell_cycle2.54058115
11MP0003123_paternal_imprinting2.48942042
12MP0010352_gastrointestinal_tract_polyps2.48456398
13MP0003693_abnormal_embryo_hatching2.47352637
14MP0002653_abnormal_ependyma_morphology2.33452189
15MP0002139_abnormal_hepatobiliary_system2.29273473
16MP0010307_abnormal_tumor_latency2.28037512
17MP0001730_embryonic_growth_arrest2.21811192
18MP0004233_abnormal_muscle_weight2.04202292
19MP0002877_abnormal_melanocyte_morpholog2.01520110
20MP0002796_impaired_skin_barrier1.99486387
21MP0005501_abnormal_skin_physiology1.92950155
22MP0001348_abnormal_lacrimal_gland1.87693011
23MP0003890_abnormal_embryonic-extraembry1.86287958
24MP0004185_abnormal_adipocyte_glucose1.83286616
25MP0003172_abnormal_lysosome_physiology1.75843345
26MP0002084_abnormal_developmental_patter1.72401042
27MP0008007_abnormal_cellular_replicative1.71040666
28MP0005380_embryogenesis_phenotype1.71008003
29MP0001672_abnormal_embryogenesis/_devel1.71008003
30MP0002089_abnormal_postnatal_growth/wei1.70730067
31MP0000350_abnormal_cell_proliferation1.69767071
32MP0005076_abnormal_cell_differentiation1.68135965
33MP0001697_abnormal_embryo_size1.67340447
34MP0003121_genomic_imprinting1.65901942
35MP0003453_abnormal_keratinocyte_physiol1.65039234
36MP0002086_abnormal_extraembryonic_tissu1.62154810
37MP0008058_abnormal_DNA_repair1.60307505
38MP0004858_abnormal_nervous_system1.59495444
39MP0002088_abnormal_embryonic_growth/wei1.58806472
40MP0003984_embryonic_growth_retardation1.58488472
41MP0010030_abnormal_orbit_morphology1.57186115
42MP0004197_abnormal_fetal_growth/weight/1.53398328
43MP0000858_altered_metastatic_potential1.53031127
44MP0002080_prenatal_lethality1.51132528
45MP0002085_abnormal_embryonic_tissue1.50137217
46MP0003329_amyloid_beta_deposits1.49757869
47MP0009840_abnormal_foam_cell1.49011128
48MP0003252_abnormal_bile_duct1.46107654
49MP0001849_ear_inflammation1.43369474
50MP0003191_abnormal_cellular_cholesterol1.41503280
51MP0005085_abnormal_gallbladder_physiolo1.37560401
52MP0003786_premature_aging1.36655741
53MP0005257_abnormal_intraocular_pressure1.36306454
54MP0005365_abnormal_bile_salt1.35624585
55MP0000537_abnormal_urethra_morphology1.34117433
56MP0008438_abnormal_cutaneous_collagen1.33647787
57MP0003763_abnormal_thymus_physiology1.33199252
58MP0000747_muscle_weakness1.32396542
59MP0010329_abnormal_lipoprotein_level1.31519710
60MP0000751_myopathy1.31213350
61MP0005360_urolithiasis1.27654319
62MP0000678_abnormal_parathyroid_gland1.27585176
63MP0004133_heterotaxia1.26764944
64MP0005666_abnormal_adipose_tissue1.24659110
65MP0008932_abnormal_embryonic_tissue1.24503475
66MP0001915_intracranial_hemorrhage1.24384270
67MP0003186_abnormal_redox_activity1.22605487
68MP0003119_abnormal_digestive_system1.22342654
69MP0009333_abnormal_splenocyte_physiolog1.21517793
70MP0002060_abnormal_skin_morphology1.19083676
71MP0005023_abnormal_wound_healing1.16215142
72MP0009053_abnormal_anal_canal1.15263149
73MP0004019_abnormal_vitamin_homeostasis1.14541460
74MP0003718_maternal_effect1.12901711
75MP0004264_abnormal_extraembryonic_tissu1.12691574
76MP0008877_abnormal_DNA_methylation1.12497927
77MP0005409_darkened_coat_color1.11851099
78MP0009672_abnormal_birth_weight1.09974296
79MP0003300_gastrointestinal_ulcer1.08967435
80MP0003566_abnormal_cell_adhesion1.06487340
81MP0004381_abnormal_hair_follicle1.06230818
82MP0000358_abnormal_cell_content/1.04189774
83MP0002166_altered_tumor_susceptibility1.04175281
84MP0004947_skin_inflammation1.03935706
85MP0000428_abnormal_craniofacial_morphol1.01994819
86MP0001873_stomach_inflammation0.99803995
87MP0005248_abnormal_Harderian_gland0.99562151
88MP0002098_abnormal_vibrissa_morphology0.98136205
89MP0001958_emphysema0.97450975
90MP0009278_abnormal_bone_marrow0.97212036
91MP0001346_abnormal_lacrimal_gland0.96517005
92MP0000733_abnormal_muscle_development0.95393619
93MP0000609_abnormal_liver_physiology0.94871775
94MP0000313_abnormal_cell_death0.94708191
95MP0002249_abnormal_larynx_morphology0.94602126
96MP0003115_abnormal_respiratory_system0.94506937
97MP0003283_abnormal_digestive_organ0.94344207
98MP0008961_abnormal_basal_metabolism0.93981652
99MP0003436_decreased_susceptibility_to0.93919603
100MP0000598_abnormal_liver_morphology0.93853672
101MP0001216_abnormal_epidermal_layer0.93493001
102MP0010234_abnormal_vibrissa_follicle0.93285757
103MP0000490_abnormal_crypts_of0.93104256
104MP0003122_maternal_imprinting0.92972980
105MP0000569_abnormal_digit_pigmentation0.92738062
106MP0001944_abnormal_pancreas_morphology0.91049598
107MP0001293_anophthalmia0.90562078
108MP0000759_abnormal_skeletal_muscle0.90403956
109MP0002970_abnormal_white_adipose0.90211611
110MP0002019_abnormal_tumor_incidence0.89588787
111MP0009931_abnormal_skin_appearance0.87833775
112MP0005395_other_phenotype0.87624394
113MP0000685_abnormal_immune_system0.87128867
114MP0008875_abnormal_xenobiotic_pharmacok0.86431312
115MP0005220_abnormal_exocrine_pancreas0.86284539
116MP0001727_abnormal_embryo_implantation0.85670722
117MP0004087_abnormal_muscle_fiber0.83441248
118MP0000003_abnormal_adipose_tissue0.82874690
119MP0000371_diluted_coat_color0.82443696
120MP0005375_adipose_tissue_phenotype0.81704834
121MP0003183_abnormal_peptide_metabolism0.80944540
122MP0003567_abnormal_fetal_cardiomyocyte0.77094735
123MP0006035_abnormal_mitochondrial_morpho0.76435184
124MP0002111_abnormal_tail_morphology0.76292483
125MP0002697_abnormal_eye_size0.75714492
126MP0003942_abnormal_urinary_system0.75396811
127MP0000377_abnormal_hair_follicle0.75340490
128MP0002269_muscular_atrophy0.74351796
129MP0002398_abnormal_bone_marrow0.74302770
130MP0003656_abnormal_erythrocyte_physiolo0.73936331
131MP0002254_reproductive_system_inflammat0.73934963
132MP0002396_abnormal_hematopoietic_system0.73886398
133MP0003221_abnormal_cardiomyocyte_apopto0.73828170
134MP0000467_abnormal_esophagus_morphology0.73727969
135MP0005621_abnormal_cell_physiology0.73305898
136MP0002925_abnormal_cardiovascular_devel0.72526410
137MP0000750_abnormal_muscle_regeneration0.71719100
138MP0000627_abnormal_mammary_gland0.71254887
139MP0001764_abnormal_homeostasis0.71050277
140MP0005384_cellular_phenotype0.69233355
141MP0000703_abnormal_thymus_morphology0.68479031
142MP0004808_abnormal_hematopoietic_stem0.67921139
143MP0001145_abnormal_male_reproductive0.67612225
144MP0002092_abnormal_eye_morphology0.67489834
145MP0005408_hypopigmentation0.66579614
146MP0000266_abnormal_heart_morphology0.66558370
147MP0010630_abnormal_cardiac_muscle0.66146540
148MP0002127_abnormal_cardiovascular_syste0.65598353
149MP0002168_other_aberrant_phenotype0.64749432
150MP0003091_abnormal_cell_migration0.64583834

Predicted human phenotypes

RankGene SetZ-score
1Hyperacusis (HP:0010780)4.41315867
2Ependymoma (HP:0002888)4.14558932
3Abnormal gallbladder physiology (HP:0012438)3.69261430
4Cholecystitis (HP:0001082)3.69261430
5Astrocytoma (HP:0009592)3.37670357
6Abnormality of the astrocytes (HP:0100707)3.37670357
7Increased connective tissue (HP:0009025)3.34058361
8Impulsivity (HP:0100710)3.30236788
9Insomnia (HP:0100785)3.22271692
10Distal lower limb amyotrophy (HP:0008944)3.07419285
11Hypoalphalipoproteinemia (HP:0003233)3.05743866
12Broad face (HP:0000283)2.98274317
13Selective tooth agenesis (HP:0001592)2.98076988
14Distal upper limb amyotrophy (HP:0007149)2.89147852
15Upper limb amyotrophy (HP:0009129)2.89147852
16Abnormality of the labia minora (HP:0012880)2.82192438
17Hypolipoproteinemia (HP:0010981)2.80599679
18Spastic diplegia (HP:0001264)2.80332324
19Centrally nucleated skeletal muscle fibers (HP:0003687)2.74186916
20Cerebral aneurysm (HP:0004944)2.73235048
21Renovascular hypertension (HP:0100817)2.72315629
22Asymmetry of the thorax (HP:0001555)2.72313188
23Medulloblastoma (HP:0002885)2.69055798
24Achilles tendon contracture (HP:0001771)2.68012504
25Glioma (HP:0009733)2.66470661
26Ankle contracture (HP:0006466)2.66228814
27Vertebral compression fractures (HP:0002953)2.64994805
28Abnormality of monocarboxylic acid metabolism (HP:0010996)2.60719516
29Neoplasm of the oral cavity (HP:0100649)2.58406272
30Deviation of the thumb (HP:0009603)2.56332629
31Difficulty climbing stairs (HP:0003551)2.48785362
32Hypobetalipoproteinemia (HP:0003563)2.48741798
33Reticulocytosis (HP:0001923)2.48550647
34Deep venous thrombosis (HP:0002625)2.46794569
35Trismus (HP:0000211)2.45984971
36Hand muscle atrophy (HP:0009130)2.45228043
37Abnormality of the Achilles tendon (HP:0005109)2.45022475
38Proximal placement of thumb (HP:0009623)2.44776486
39Abnormality of pyrimidine metabolism (HP:0004353)2.42499910
40Degeneration of anterior horn cells (HP:0002398)2.40848838
41Abnormality of the anterior horn cell (HP:0006802)2.40848838
42Flat acetabular roof (HP:0003180)2.40822154
43Micronodular cirrhosis (HP:0001413)2.39326918
44Adenoma sebaceum (HP:0009720)2.37051435
45Angiofibromas (HP:0010615)2.37051435
46Long palpebral fissure (HP:0000637)2.35956833
47Ragged-red muscle fibers (HP:0003200)2.35093264
48Distal lower limb muscle weakness (HP:0009053)2.33694682
49Colon cancer (HP:0003003)2.32709292
50Rhabdomyosarcoma (HP:0002859)2.28830133
51Intrahepatic cholestasis (HP:0001406)2.28039856
52Urethral obstruction (HP:0000796)2.25197912
53Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.24238341
54Protrusio acetabuli (HP:0003179)2.21465045
55Abnormality of the aortic arch (HP:0012303)2.18688195
56Broad distal phalanx of finger (HP:0009836)2.17586136
57Vascular calcification (HP:0004934)2.14401152
58Back pain (HP:0003418)2.12050623
59Progressive muscle weakness (HP:0003323)2.11425629
60Hemorrhage of the eye (HP:0011885)2.11192449
61Abnormal number of incisors (HP:0011064)2.11134693
62Neoplasm of striated muscle (HP:0009728)2.11020199
63Hepatocellular carcinoma (HP:0001402)2.10220317
64Cardiovascular calcification (HP:0011915)2.10059302
65Ulnar bowing (HP:0003031)2.08865417
66J-shaped sella turcica (HP:0002680)2.08854046
67Pointed chin (HP:0000307)2.08750086
68Progressive sensorineural hearing impairment (HP:0000408)2.08523533
69Volvulus (HP:0002580)2.07513675
70Subacute progressive viral hepatitis (HP:0006572)2.07065241
71Lower limb amyotrophy (HP:0007210)2.06781769
72Hyperglycinuria (HP:0003108)2.06562257
73Delayed puberty (HP:0000823)2.06031359
74Biliary tract neoplasm (HP:0100574)2.04326675
75Ketoacidosis (HP:0001993)2.03671175
76Cholelithiasis (HP:0001081)2.03063102
77Cellulitis (HP:0100658)2.02961398
78Abnormality of sulfur amino acid metabolism (HP:0004339)2.01834439
79Orthostatic hypotension (HP:0001278)2.01829695
80Increased nuchal translucency (HP:0010880)2.00147742
81Birth length less than 3rd percentile (HP:0003561)1.99819530
82Overriding aorta (HP:0002623)1.99481515
83Microvesicular hepatic steatosis (HP:0001414)1.98321414
84Multiple enchondromatosis (HP:0005701)1.98191379
85Hypoglycemic coma (HP:0001325)1.98187506
86Truncal obesity (HP:0001956)1.97663981
87Elfin facies (HP:0004428)1.97121192
88Prominent nose (HP:0000448)1.96286360
89Insulin-resistant diabetes mellitus (HP:0000831)1.94335551
90Chorioretinal atrophy (HP:0000533)1.94277539
91Advanced eruption of teeth (HP:0006288)1.94135687
92Biconcave vertebral bodies (HP:0004586)1.91201197
93Patellar dislocation (HP:0002999)1.91162132
94Bowel diverticulosis (HP:0005222)1.90943461
95Peripheral hypomyelination (HP:0007182)1.90357523
96Metaphyseal cupping (HP:0003021)1.90131036
97High pitched voice (HP:0001620)1.90090802
98Renal duplication (HP:0000075)1.90022133
99Progressive external ophthalmoplegia (HP:0000590)1.88124543
100Insulin resistance (HP:0000855)1.88094304
101Gastrointestinal carcinoma (HP:0002672)1.88063582
102Malignant gastrointestinal tract tumors (HP:0006749)1.88063582
103Abnormality of the calcaneus (HP:0008364)1.87451594
104Hypercortisolism (HP:0001578)1.87308073
105Ketosis (HP:0001946)1.87250625
106Short nail (HP:0001799)1.86730363
107Stridor (HP:0010307)1.86208937
108Abnormality of the lower motor neuron (HP:0002366)1.85842398
109Atrophy/Degeneration involving motor neurons (HP:0007373)1.85504292
110Premature rupture of membranes (HP:0001788)1.85108060
111Intestinal polyp (HP:0005266)1.84871336
112Aneurysm (HP:0002617)1.84285612
113Xanthomatosis (HP:0000991)1.84212741
114Ovarian neoplasm (HP:0100615)1.83796671
115Hyperglycinemia (HP:0002154)1.83598385
116Progressive hearing impairment (HP:0001730)1.82633596
117Entropion (HP:0000621)1.82474873
118Abnormal neuron morphology (HP:0012757)1.82310044
119Abnormality of the motor neurons (HP:0002450)1.82310044
120Intestinal polyposis (HP:0200008)1.81775381
121Agnosia (HP:0010524)1.81716351
122Myopathic facies (HP:0002058)1.81307303
123Abnormality of the thoracic spine (HP:0100711)1.81170239
124Cafe-au-lait spot (HP:0000957)1.80796177
125Dysmetric saccades (HP:0000641)1.80767691
126Abnormality of reticulocytes (HP:0004312)1.80145592
127Abnormality of endocrine pancreas physiology (HP:0012093)1.79310516
128Abnormality of the pancreatic islet cells (HP:0006476)1.79310516
129Obsessive-compulsive behavior (HP:0000722)1.78566352
130Limb hypertonia (HP:0002509)1.78459113
131Thrombocytosis (HP:0001894)1.78138862
132Supranuclear gaze palsy (HP:0000605)1.78057883
133Hypertensive crisis (HP:0100735)1.77300673
134Insidious onset (HP:0003587)1.76924489
135Termporal pattern (HP:0011008)1.76924489
136Deep palmar crease (HP:0006191)1.76718892
137Secondary amenorrhea (HP:0000869)1.76425006
138Neoplasm of the liver (HP:0002896)1.75506013
139Growth hormone excess (HP:0000845)1.75306673
140Heterotopia (HP:0002282)1.73595733
141Neoplasm of the small intestine (HP:0100833)1.73575029
142Seborrheic dermatitis (HP:0001051)1.73498375
143Neuronal loss in central nervous system (HP:0002529)1.73496769
144Neoplasm of the pancreas (HP:0002894)1.73323432
145Fragile skin (HP:0001030)1.72649906
146Sparse lateral eyebrow (HP:0005338)1.72618032
147Flattened epiphyses (HP:0003071)1.72436921
148Epidermoid cyst (HP:0200040)1.71443818
149Hepatoblastoma (HP:0002884)1.71350630
150Abnormal pancreas size (HP:0012094)1.70611146
151Rough bone trabeculation (HP:0100670)1.69430051
152Shawl scrotum (HP:0000049)1.69171783
153Long eyelashes (HP:0000527)1.68185885
154Abnormality of glycolysis (HP:0004366)1.68153443
155Abnormality of nucleobase metabolism (HP:0010932)1.67995805
156Abnormal biliary tract morphology (HP:0012440)1.67877212
157Hammertoe (HP:0001765)1.67835191
158Asymmetric septal hypertrophy (HP:0001670)1.67790729
159Abnormality of the distal phalanges of the toes (HP:0010182)1.67493667
160Missing ribs (HP:0000921)1.67134724
161Hypoparathyroidism (HP:0000829)1.66513551
162Subcapsular cataract (HP:0000523)1.65797424
163Colitis (HP:0002583)1.65635560
164Foot dorsiflexor weakness (HP:0009027)1.65587319
165Apathy (HP:0000741)1.65139634
166Natal tooth (HP:0000695)1.64658755
167Distal sensory impairment (HP:0002936)1.64587799
168Absent thumb (HP:0009777)1.64417712
169Overlapping toe (HP:0001845)1.63893693
170Fibroma (HP:0010614)1.63815444
171Neoplasm of the rectum (HP:0100743)1.63432895
172Patellar aplasia (HP:0006443)1.63374594
173Hyperglycemia (HP:0003074)1.63139199
174Neoplasm of the colon (HP:0100273)1.62815985
175Cerebral inclusion bodies (HP:0100314)1.62780386
176Premature skin wrinkling (HP:0100678)1.60386711
177Abnormality of carpal bone ossification (HP:0006257)1.59636910
178Diminished motivation (HP:0000745)1.58979953
179Thoracic kyphosis (HP:0002942)1.58973725
180Hypoplasia of the capital femoral epiphysis (HP:0003090)1.57062535
181Abnormal gallbladder morphology (HP:0012437)1.56340891
182Abnormal ossification of hand bones (HP:0005921)1.52573107
183Hypokinesia (HP:0002375)1.51175521
184Hepatitis (HP:0012115)1.50386221
185Abnormality of the gallbladder (HP:0005264)1.50090224
186Disproportionate tall stature (HP:0001519)1.49587825
187Precocious puberty (HP:0000826)1.49569042
188Segmental peripheral demyelination/remyelination (HP:0003481)1.49021101

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG14.25179560
2CDK123.72358446
3PKN23.18043247
4BRD42.81697043
5EEF2K2.72291555
6CDC72.69189274
7PASK2.67777125
8NEK12.66884916
9NME22.63604375
10PTK62.62640700
11TSSK62.60997659
12MAP3K102.59462198
13TRIB32.34549707
14PRPF4B2.23723923
15BUB12.18784339
16TTK2.16833697
17STK102.07584877
18IRAK31.95786813
19SCYL21.94527829
20EPHA21.90796929
21NEK21.79713540
22MELK1.72857166
23RPS6KB21.72667845
24SIK11.68753939
25PLK11.64914710
26PAK41.60540870
27WEE11.58862911
28PDGFRA1.54706195
29FGFR11.42894112
30BCKDK1.41616439
31ATR1.40650855
32FLT31.40605368
33MAP3K131.38944065
34FGFR41.38146486
35MTOR1.35256299
36SIK21.29519809
37CDK71.23125283
38NEK91.22383526
39CCNB11.21791073
40TESK11.19973804
41TGFBR11.19589103
42ARAF1.19580310
43TTN1.17237828
44VRK21.15897629
45CDK41.14554406
46MAP3K81.14356952
47AURKB1.11805131
48EIF2AK11.11412420
49LRRK21.08907522
50PLK31.08003813
51MST1R1.07686820
52ERN11.07023311
53CHEK11.04533354
54SRPK11.04427849
55ALK1.01395835
56MAP2K21.00252622
57PTK20.98977401
58MAPKAPK30.96719625
59LATS10.93566699
60RET0.90685733
61CHEK20.90047208
62CDK60.88500743
63MAP3K110.86597189
64TBK10.84722984
65LMTK20.84064210
66TAOK20.82965601
67ERBB40.80995096
68CDK20.80633871
69MAP3K50.80600374
70STK30.76866909
71PLK40.75217241
72EPHB10.74906314
73ATM0.73146601
74PIM20.72541450
75GRK60.72304195
76MARK20.71924122
77AURKA0.71403905
78MAP3K140.69641663
79KSR20.68643996
80DAPK10.68262166
81RPS6KA40.67561707
82PRKD30.66415452
83CDK90.65914285
84PIM10.65333628
85CDK10.64390530
86CSNK1E0.63414352
87TLK10.62914302
88RIPK40.62606544
89RPS6KB10.61762433
90PRKD20.61586883
91NME10.61060260
92MAP2K30.60874144
93BMX0.60748944
94ICK0.60366915
95PDPK10.59861249
96MKNK10.56028406
97LATS20.55877148
98CHUK0.53641789
99PDK30.52847037
100PDK40.52847037
101DYRK1B0.52714770
102TYRO30.52622371
103MAP3K10.51569314
104DDR20.50819262
105RPS6KA20.50805074
106AKT20.50365410
107ITK0.50194010
108NTRK10.49692342
109TESK20.49368644
110CLK10.47341295
111BRAF0.46736834
112PAK20.43607679
113IRAK20.43504712
114KSR10.43384893
115CSF1R0.43193920
116CSNK2A20.42616187
117STK40.42433937
118CDK11A0.42261316
119HIPK20.41003912
120MAPK140.40900796
121MAP3K30.40222946
122CDC42BPA0.40152781
123FGFR20.40053615
124TAOK10.39634603
125ILK0.39514389
126PRKCI0.38699890
127CAMKK10.38152055
128MAPKAPK20.37683603
129RIPK10.36952318
130MAP3K90.36368094
131CDK150.36194724
132PRKDC0.35144291
133MAP3K70.34861485
134SIK30.33519947
135ACVR1B0.32214020
136MAP4K10.31781672
137MAPK10.31755932
138CAMK1D0.30751595
139FGFR30.30220861
140JAK20.30143023
141MOS0.29945923
142MAPK110.29070767
143CSNK1D0.28555056
144FER0.28513123
145AKT10.27290699

Predicted pathways (KEGG)

RankGene SetZ-score
1One carbon pool by folate_Homo sapiens_hsa006703.08638150
2Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.02866662
3DNA replication_Homo sapiens_hsa030302.85858226
4Mismatch repair_Homo sapiens_hsa034302.80318146
5Selenocompound metabolism_Homo sapiens_hsa004502.59098367
6RNA transport_Homo sapiens_hsa030132.53520500
7Other glycan degradation_Homo sapiens_hsa005112.51234392
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.38039700
9* Spliceosome_Homo sapiens_hsa030402.32409666
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.29735079
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.15207705
12Cell cycle_Homo sapiens_hsa041102.15157376
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.03385784
14Biosynthesis of amino acids_Homo sapiens_hsa012301.99290474
15Base excision repair_Homo sapiens_hsa034101.95525081
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.88482742
17Cysteine and methionine metabolism_Homo sapiens_hsa002701.87077775
18Acute myeloid leukemia_Homo sapiens_hsa052211.81271353
19Non-small cell lung cancer_Homo sapiens_hsa052231.79145806
20Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.64772014
21Caffeine metabolism_Homo sapiens_hsa002321.57795476
22Primary bile acid biosynthesis_Homo sapiens_hsa001201.55173874
23Carbon metabolism_Homo sapiens_hsa012001.53954565
24Proteasome_Homo sapiens_hsa030501.51773677
25Nucleotide excision repair_Homo sapiens_hsa034201.49259057
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.46071619
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.44173783
28Pancreatic cancer_Homo sapiens_hsa052121.43915443
29RNA polymerase_Homo sapiens_hsa030201.40850059
30mRNA surveillance pathway_Homo sapiens_hsa030151.38616684
31Lysine degradation_Homo sapiens_hsa003101.38470522
32Tryptophan metabolism_Homo sapiens_hsa003801.37422153
33Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.37218938
34B cell receptor signaling pathway_Homo sapiens_hsa046621.36460671
35Fatty acid degradation_Homo sapiens_hsa000711.34098665
36Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.30157405
37Vibrio cholerae infection_Homo sapiens_hsa051101.25731213
38Shigellosis_Homo sapiens_hsa051311.24846840
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.24809004
40Pentose and glucuronate interconversions_Homo sapiens_hsa000401.23256259
41VEGF signaling pathway_Homo sapiens_hsa043701.21985223
42N-Glycan biosynthesis_Homo sapiens_hsa005101.18913761
43Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.17723042
44Pyruvate metabolism_Homo sapiens_hsa006201.13699318
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.12733746
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12490394
47Arginine biosynthesis_Homo sapiens_hsa002201.10696359
48RNA degradation_Homo sapiens_hsa030181.10015116
49Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.09178973
50mTOR signaling pathway_Homo sapiens_hsa041501.09055754
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.08874312
52Prion diseases_Homo sapiens_hsa050201.07284791
53Propanoate metabolism_Homo sapiens_hsa006401.06843138
54Fatty acid metabolism_Homo sapiens_hsa012121.06696146
55Pyrimidine metabolism_Homo sapiens_hsa002401.06560198
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.04364056
57Starch and sucrose metabolism_Homo sapiens_hsa005001.01570197
58Homologous recombination_Homo sapiens_hsa034401.01538320
59Neurotrophin signaling pathway_Homo sapiens_hsa047221.00982161
60Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.00245900
61Systemic lupus erythematosus_Homo sapiens_hsa053221.00035884
62p53 signaling pathway_Homo sapiens_hsa041150.97575549
63Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.96365724
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.96208659
65Galactose metabolism_Homo sapiens_hsa000520.95207855
66Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.93973716
67Glioma_Homo sapiens_hsa052140.93362867
68Hepatitis B_Homo sapiens_hsa051610.92881385
69Central carbon metabolism in cancer_Homo sapiens_hsa052300.92306474
70ErbB signaling pathway_Homo sapiens_hsa040120.91581629
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.90612606
72Renal cell carcinoma_Homo sapiens_hsa052110.90426034
73Glycosaminoglycan degradation_Homo sapiens_hsa005310.90328254
74Complement and coagulation cascades_Homo sapiens_hsa046100.89245234
75Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.89244810
76Herpes simplex infection_Homo sapiens_hsa051680.88844432
77Fructose and mannose metabolism_Homo sapiens_hsa000510.87469219
78Fanconi anemia pathway_Homo sapiens_hsa034600.86589565
79Oocyte meiosis_Homo sapiens_hsa041140.86139342
80Hepatitis C_Homo sapiens_hsa051600.85714362
81Nitrogen metabolism_Homo sapiens_hsa009100.85163006
82Viral carcinogenesis_Homo sapiens_hsa052030.85137885
83Endocytosis_Homo sapiens_hsa041440.83654719
84Colorectal cancer_Homo sapiens_hsa052100.78368034
85Epstein-Barr virus infection_Homo sapiens_hsa051690.77243617
86HTLV-I infection_Homo sapiens_hsa051660.76827152
87Phenylalanine metabolism_Homo sapiens_hsa003600.76377305
88Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.76281826
89Leukocyte transendothelial migration_Homo sapiens_hsa046700.75994237
90MicroRNAs in cancer_Homo sapiens_hsa052060.75371428
91Prostate cancer_Homo sapiens_hsa052150.74755913
92Hippo signaling pathway_Homo sapiens_hsa043900.73366830
93Folate biosynthesis_Homo sapiens_hsa007900.73067164
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72571279
95Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.71035184
96Pentose phosphate pathway_Homo sapiens_hsa000300.69598371
97AMPK signaling pathway_Homo sapiens_hsa041520.66856246
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.66727122
99PPAR signaling pathway_Homo sapiens_hsa033200.65644219
100Influenza A_Homo sapiens_hsa051640.64646444
101Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63627227
102Notch signaling pathway_Homo sapiens_hsa043300.63138382
103Antigen processing and presentation_Homo sapiens_hsa046120.62757448
104Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62587732
105Inositol phosphate metabolism_Homo sapiens_hsa005620.62346074
106Non-homologous end-joining_Homo sapiens_hsa034500.62110958
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.61895527
108Retinol metabolism_Homo sapiens_hsa008300.61771983
109Bladder cancer_Homo sapiens_hsa052190.61552144
110Viral myocarditis_Homo sapiens_hsa054160.61525034
111Tyrosine metabolism_Homo sapiens_hsa003500.61518316
112Adherens junction_Homo sapiens_hsa045200.60738314
113AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59397999
114Insulin resistance_Homo sapiens_hsa049310.58547827
115Salmonella infection_Homo sapiens_hsa051320.58468119
116Choline metabolism in cancer_Homo sapiens_hsa052310.57325722
117Small cell lung cancer_Homo sapiens_hsa052220.57263630
118Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57234924
119TGF-beta signaling pathway_Homo sapiens_hsa043500.56528122
120Peroxisome_Homo sapiens_hsa041460.56504420
121Lysosome_Homo sapiens_hsa041420.54838327
122Glucagon signaling pathway_Homo sapiens_hsa049220.54837338
123Prolactin signaling pathway_Homo sapiens_hsa049170.51053369
124Vitamin B6 metabolism_Homo sapiens_hsa007500.50880572
125Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49993026
126Thyroid cancer_Homo sapiens_hsa052160.49738240
127Chronic myeloid leukemia_Homo sapiens_hsa052200.49360487
128Estrogen signaling pathway_Homo sapiens_hsa049150.47535675
129Toxoplasmosis_Homo sapiens_hsa051450.47100688
130Focal adhesion_Homo sapiens_hsa045100.46842637
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46611294
132Butanoate metabolism_Homo sapiens_hsa006500.45499205
133Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45045023
134Sphingolipid signaling pathway_Homo sapiens_hsa040710.44727169
135Endometrial cancer_Homo sapiens_hsa052130.43376371
136beta-Alanine metabolism_Homo sapiens_hsa004100.43160259
137T cell receptor signaling pathway_Homo sapiens_hsa046600.42812097
138Cyanoamino acid metabolism_Homo sapiens_hsa004600.42323234
139Ribosome_Homo sapiens_hsa030100.41997795
140Bile secretion_Homo sapiens_hsa049760.41895002
141Basal cell carcinoma_Homo sapiens_hsa052170.41494416
142Proteoglycans in cancer_Homo sapiens_hsa052050.41491115
143Sulfur relay system_Homo sapiens_hsa041220.38940755
144HIF-1 signaling pathway_Homo sapiens_hsa040660.37451587
145FoxO signaling pathway_Homo sapiens_hsa040680.36251715
146Apoptosis_Homo sapiens_hsa042100.36073277
147Insulin signaling pathway_Homo sapiens_hsa049100.34551804
148Chemical carcinogenesis_Homo sapiens_hsa052040.33675520

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