PRPF8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is a component of both U2- and U12-dependent spliceosomes, and found to be essential for the catalytic step II in pre-mRNA splicing process. It contains several WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp8 protein. This gene is a candidate gene for autosomal dominant retinitis pigmentosa. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.88804211
2nuclear pore organization (GO:0006999)5.64789308
3pre-miRNA processing (GO:0031054)5.40563071
4DNA unwinding involved in DNA replication (GO:0006268)5.00269978
5regulation of translational fidelity (GO:0006450)4.51736362
6mitotic sister chromatid cohesion (GO:0007064)4.51308753
7Golgi transport vesicle coating (GO:0048200)4.44271254
8COPI coating of Golgi vesicle (GO:0048205)4.44271254
9negative regulation of histone methylation (GO:0031061)4.35706435
10folic acid-containing compound biosynthetic process (GO:0009396)4.23984416
11protein localization to kinetochore (GO:0034501)4.22720820
12pore complex assembly (GO:0046931)4.19839883
13regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.11263351
14mitotic nuclear envelope disassembly (GO:0007077)4.09498507
15dosage compensation (GO:0007549)4.07699006
16heterochromatin organization (GO:0070828)3.97567467
17nuclear envelope disassembly (GO:0051081)3.89544543
18membrane disassembly (GO:0030397)3.89544543
19regulation of histone H3-K27 methylation (GO:0061085)3.89267462
20regulation of RNA export from nucleus (GO:0046831)3.87055154
21DNA duplex unwinding (GO:0032508)3.84353819
22DNA geometric change (GO:0032392)3.81469683
23regulation of histone H3-K9 methylation (GO:0051570)3.80674343
24sister chromatid segregation (GO:0000819)3.77031547
25glucocorticoid receptor signaling pathway (GO:0042921)3.71422735
26regulation of translational termination (GO:0006449)3.64906516
27mitotic chromosome condensation (GO:0007076)3.53442831
28protein export from nucleus (GO:0006611)3.52302807
29peptidyl-lysine dimethylation (GO:0018027)3.50394484
30NLS-bearing protein import into nucleus (GO:0006607)3.48283628
31histone H2A monoubiquitination (GO:0035518)3.47135087
32cytoskeletal anchoring at plasma membrane (GO:0007016)3.43763194
33RNA stabilization (GO:0043489)3.42540718
34mRNA stabilization (GO:0048255)3.42540718
35negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.40128733
36protein localization to chromosome, centromeric region (GO:0071459)3.39555634
37chromatin assembly (GO:0031497)3.37741654
38adherens junction assembly (GO:0034333)3.37561120
39DNA topological change (GO:0006265)3.32762615
40IMP biosynthetic process (GO:0006188)3.32228016
41regulation of mammary gland epithelial cell proliferation (GO:0033599)3.31355789
42regulation of sister chromatid cohesion (GO:0007063)3.30677282
43cell-substrate adherens junction assembly (GO:0007045)3.25675923
44focal adhesion assembly (GO:0048041)3.25675923
45regulation of gene silencing by RNA (GO:0060966)3.24149215
46regulation of posttranscriptional gene silencing (GO:0060147)3.24149215
47regulation of gene silencing by miRNA (GO:0060964)3.24149215
48DNA replication-dependent nucleosome assembly (GO:0006335)3.23381419
49DNA replication-dependent nucleosome organization (GO:0034723)3.23381419
50translesion synthesis (GO:0019985)3.21774344
51regulation of spindle organization (GO:0090224)3.21697735
52cytoplasmic mRNA processing body assembly (GO:0033962)3.21582359
53mitotic sister chromatid segregation (GO:0000070)3.20939967
54retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.19282968
55regulation of mitotic spindle organization (GO:0060236)3.18494403
56nuclear envelope organization (GO:0006998)3.17128025
57positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.15748142
58positive regulation of chromosome segregation (GO:0051984)3.12977580
59activation of Rac GTPase activity (GO:0032863)3.11268203
60regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.09243647
61regulation of nucleobase-containing compound transport (GO:0032239)3.05552310
62positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.03184436
63positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.03184436
64positive regulation of mitotic sister chromatid separation (GO:1901970)3.03184436
65negative regulation of DNA repair (GO:0045738)3.01714025
66gene silencing by RNA (GO:0031047)3.00830480
67protein localization to microtubule (GO:0035372)3.00280373
68histone H3-K36 demethylation (GO:0070544)3.00102986
69negative regulation of mRNA metabolic process (GO:1903312)3.00039455
70paraxial mesoderm development (GO:0048339)2.99956166
71DNA strand elongation involved in DNA replication (GO:0006271)2.98802973
72positive regulation of SMAD protein import into nucleus (GO:0060391)2.98801086
73positive regulation of histone deacetylation (GO:0031065)2.97369577
74negative regulation of RNA splicing (GO:0033119)2.96721684
75gene silencing (GO:0016458)2.96041298
76corticosteroid receptor signaling pathway (GO:0031958)2.94880629
77DNA strand elongation (GO:0022616)2.93519391
78establishment of apical/basal cell polarity (GO:0035089)2.93115791
79embryonic process involved in female pregnancy (GO:0060136)2.90582018
80negative regulation of mRNA processing (GO:0050686)2.89510854
81positive regulation of RNA splicing (GO:0033120)2.88680971
82protein-DNA complex disassembly (GO:0032986)2.86922176
83nucleosome disassembly (GO:0006337)2.86922176
84DNA conformation change (GO:0071103)2.86507862
85negative regulation of histone modification (GO:0031057)2.84584306
86DNA packaging (GO:0006323)2.83611468
87alternative mRNA splicing, via spliceosome (GO:0000380)2.82870301
88nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.80010401
89stress granule assembly (GO:0034063)2.78434670
90cellular response to epidermal growth factor stimulus (GO:0071364)2.78094784
91cellular protein complex localization (GO:0034629)2.77160095
92cell-substrate junction assembly (GO:0007044)2.76709810
93apoptotic process involved in morphogenesis (GO:0060561)2.76567181
94negative regulation of cell size (GO:0045792)2.75320178
95protein localization to chromosome (GO:0034502)2.75163480
96protein complex localization (GO:0031503)2.74834132
97positive regulation of gene expression, epigenetic (GO:0045815)2.73925180
98proline biosynthetic process (GO:0006561)2.73420587
99IMP metabolic process (GO:0046040)2.73393592
100histone H4-K12 acetylation (GO:0043983)2.72592672
101planar cell polarity pathway involved in neural tube closure (GO:0090179)2.70932682
102chromatin silencing (GO:0006342)2.70078795
1033-UTR-mediated mRNA stabilization (GO:0070935)2.69035053
104epithelial cell differentiation involved in prostate gland development (GO:0060742)2.68384200
105DNA synthesis involved in DNA repair (GO:0000731)2.68057155
106mRNA transport (GO:0051028)2.67995155
107negative regulation of chromatin modification (GO:1903309)2.67611782
108regulation of glucose import in response to insulin stimulus (GO:2001273)2.67340662
109response to epidermal growth factor (GO:0070849)2.67269340
110positive regulation of DNA-dependent DNA replication (GO:2000105)2.67024578
111peptidyl-arginine omega-N-methylation (GO:0035247)2.65643670
112regulation of mRNA stability (GO:0043488)2.65609726
113* spliceosomal tri-snRNP complex assembly (GO:0000244)2.65546418
114DNA replication initiation (GO:0006270)2.65370986
115regulation of DNA endoreduplication (GO:0032875)2.63975002
116hippo signaling (GO:0035329)2.61475738
117regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.60388259
118negative regulation of erythrocyte differentiation (GO:0045647)2.60325623
119regulation of NFAT protein import into nucleus (GO:0051532)2.60033893
120histone H4-K5 acetylation (GO:0043981)2.60026002
121histone H4-K8 acetylation (GO:0043982)2.60026002
122chromatin assembly or disassembly (GO:0006333)2.58640706
123vesicle coating (GO:0006901)2.58356705
124regulation of histone H3-K4 methylation (GO:0051569)2.57479447
125negative regulation of gene expression, epigenetic (GO:0045814)2.57358257
126regulation of centriole replication (GO:0046599)2.56789704
127intracellular estrogen receptor signaling pathway (GO:0030520)2.56632683
128tetrahydrofolate metabolic process (GO:0046653)2.56288975
129regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.56077023
130chromosome condensation (GO:0030261)2.55861718
131regulation of hippo signaling (GO:0035330)2.55119047
132histone H4-K16 acetylation (GO:0043984)2.54952639
133regulation of DNA damage checkpoint (GO:2000001)2.54595270
134nucleobase biosynthetic process (GO:0046112)2.54177878
135formation of translation preinitiation complex (GO:0001731)2.53543796
136regulation of early endosome to late endosome transport (GO:2000641)2.53337414
137peptidyl-threonine phosphorylation (GO:0018107)2.52774647
138peptidyl-threonine modification (GO:0018210)2.51852582
139trophectodermal cell differentiation (GO:0001829)2.51630765
140maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.49226673
141snRNA metabolic process (GO:0016073)2.48771346
142histone lysine demethylation (GO:0070076)2.48592010
143protein localization to endosome (GO:0036010)2.48443668
144regulation of histone methylation (GO:0031060)2.47399246
145positive regulation of cell cycle checkpoint (GO:1901978)2.47251770
146regulation of chromatin binding (GO:0035561)2.46949698
147embryonic camera-type eye morphogenesis (GO:0048596)2.46116140
148G1 DNA damage checkpoint (GO:0044783)2.44969841

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.40019175
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.45961391
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.13757672
4MYC_22102868_ChIP-Seq_BL_Human3.55063329
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.26987264
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.14189054
7* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.57216982
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.53806136
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.48868455
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.37938708
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.30206279
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.13880617
13E2F1_21310950_ChIP-Seq_MCF-7_Human2.06311140
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.06090071
15AR_21909140_ChIP-Seq_LNCAP_Human2.04598311
16SALL1_21062744_ChIP-ChIP_HESCs_Human1.96596633
17CIITA_25753668_ChIP-Seq_RAJI_Human1.90507241
18VDR_21846776_ChIP-Seq_THP-1_Human1.84169564
19TCF7_22412390_ChIP-Seq_EML_Mouse1.83618394
20SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.82573825
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.80532297
22ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.79940608
23ESR1_15608294_ChIP-ChIP_MCF-7_Human1.78970602
24POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.70614093
25KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.68687049
26KDM2B_26808549_Chip-Seq_DND41_Human1.67956668
27CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.67091604
28KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.62865608
29RACK7_27058665_Chip-Seq_MCF-7_Human1.62598451
30ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.54143872
31NELFA_20434984_ChIP-Seq_ESCs_Mouse1.52370663
32* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.52111566
33SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.52066879
34TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52015045
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.48743119
36ZNF263_19887448_ChIP-Seq_K562_Human1.47537698
37* LXR_22292898_ChIP-Seq_THP-1_Human1.47357623
38TP63_19390658_ChIP-ChIP_HaCaT_Human1.47277729
39ZFP281_27345836_Chip-Seq_ESCs_Mouse1.44823140
40ZFP281_18757296_ChIP-ChIP_E14_Mouse1.43196379
41* XRN2_22483619_ChIP-Seq_HELA_Human1.40091644
42SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.39651228
43KDM5A_27292631_Chip-Seq_BREAST_Human1.38625749
44ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.38520114
45MYCN_18555785_ChIP-Seq_MESCs_Mouse1.38498641
46CLOCK_20551151_ChIP-Seq_293T_Human1.37925597
47DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.37751066
48KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.35858054
49MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.35172683
50KDM2B_26808549_Chip-Seq_K562_Human1.33935083
51NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.31692690
52STAT3_1855785_ChIP-Seq_MESCs_Mouse1.30113395
53NANOG_21062744_ChIP-ChIP_HESCs_Human1.29370418
54MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.27357180
55* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.26613390
56UTX_26944678_Chip-Seq_JUKART_Human1.25832622
57DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.25371675
58PKCTHETA_26484144_Chip-Seq_BREAST_Human1.24815393
59KLF4_18555785_ChIP-Seq_MESCs_Mouse1.24119167
60ELK3_25401928_ChIP-Seq_HUVEC_Human1.23116974
61* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.22791278
62CHD1_26751641_Chip-Seq_LNCaP_Human1.22639445
63* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.22055254
64NANOG_18555785_ChIP-Seq_MESCs_Mouse1.21958673
65RBPJ_22232070_ChIP-Seq_NCS_Mouse1.20685305
66TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.20297935
67TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.20248789
68KDM2B_26808549_Chip-Seq_SUP-B15_Human1.19675787
69SOX2_18555785_ChIP-Seq_MESCs_Mouse1.16245135
70* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.16011721
71SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.14744699
72MAF_26560356_Chip-Seq_TH1_Human1.13103615
73KDM2B_26808549_Chip-Seq_JURKAT_Human1.13007768
74STAT6_21828071_ChIP-Seq_BEAS2B_Human1.12389429
75P300_27058665_Chip-Seq_ZR-75-30cells_Human1.12215013
76HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.10684313
77NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.10312484
78* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10227550
79DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.10060815
80* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.09775903
81HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.09714859
82ATF3_27146783_Chip-Seq_COLON_Human1.08837393
83NCOR1_26117541_ChIP-Seq_K562_Human1.07811309
84* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.07603347
85TCF3_18692474_ChIP-Seq_MEFs_Mouse1.07203599
86THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.06040741
87* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05653263
88FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.03799058
89EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.02659331
90CREB1_26743006_Chip-Seq_LNCaP_Human1.02352744
91* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.01875101
92PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.01806688
93KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01744506
94CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01357901
95HIF1A_21447827_ChIP-Seq_MCF-7_Human0.99852321
96UBF1/2_26484160_Chip-Seq_HMECs_Human0.99831533
97NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.99160572
98KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.99147137
99TFEB_21752829_ChIP-Seq_HELA_Human0.99096268
100CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.98542104
101TP63_17297297_ChIP-ChIP_HaCaT_Human0.98491996
102RARG_19884340_ChIP-ChIP_MEFs_Mouse0.98400457
103FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.97937936
104NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.96440079
105PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95302929
106ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.94569949
107TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.93540339
108UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.92722472
109WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.92503184
110ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.92403459
111POU5F1_16518401_ChIP-PET_MESCs_Mouse0.92171453
112TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91399370
113TP53_22127205_ChIP-Seq_IMR90_Human0.91368210
114TCF3_18692474_ChIP-Seq_MESCs_Mouse0.90975011
115SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.90513554
116TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.90395432
117SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.89626245
118SMC4_20622854_ChIP-Seq_HELA_Human0.89254335
119ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.89146901
120RUNX1_27514584_Chip-Seq_MCF-7_Human0.89111859
121TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89035965
122STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.88733750
123CTCF_27219007_Chip-Seq_ERYTHROID_Human0.88470308
124BRD4_27068464_Chip-Seq_AML-cells_Mouse0.87885997
125GATA6_25053715_ChIP-Seq_YYC3_Human0.87130587
126MYB_26560356_Chip-Seq_TH1_Human0.86959034

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010352_gastrointestinal_tract_polyps3.64624387
2MP0003705_abnormal_hypodermis_morpholog3.64088499
3MP0005076_abnormal_cell_differentiation3.47842804
4MP0002009_preneoplasia3.24100186
5MP0003111_abnormal_nucleus_morphology2.86459416
6MP0010094_abnormal_chromosome_stability2.82564648
7MP0010307_abnormal_tumor_latency2.63830154
8MP0008057_abnormal_DNA_replication2.52265585
9MP0003077_abnormal_cell_cycle2.50331859
10MP0001730_embryonic_growth_arrest2.39556013
11MP0004957_abnormal_blastocyst_morpholog2.38849787
12MP0010234_abnormal_vibrissa_follicle2.29899801
13MP0005451_abnormal_body_composition2.26351800
14MP0003693_abnormal_embryo_hatching2.26195879
15MP0004197_abnormal_fetal_growth/weight/2.23638970
16MP0000537_abnormal_urethra_morphology2.21909295
17MP0000350_abnormal_cell_proliferation2.09625342
18MP0005409_darkened_coat_color2.09448581
19MP0002084_abnormal_developmental_patter2.05642002
20MP0002396_abnormal_hematopoietic_system2.02745354
21MP0005380_embryogenesis_phenotype1.96899150
22MP0001672_abnormal_embryogenesis/_devel1.96899150
23MP0003984_embryonic_growth_retardation1.92395101
24MP0002088_abnormal_embryonic_growth/wei1.91955395
25MP0003123_paternal_imprinting1.88675759
26MP0003300_gastrointestinal_ulcer1.87436455
27MP0002086_abnormal_extraembryonic_tissu1.86120948
28MP0001697_abnormal_embryo_size1.81581648
29MP0002085_abnormal_embryonic_tissue1.80363207
30MP0009053_abnormal_anal_canal1.79085242
31MP0000569_abnormal_digit_pigmentation1.75747362
32MP0003121_genomic_imprinting1.73318020
33MP0004808_abnormal_hematopoietic_stem1.71492965
34MP0003890_abnormal_embryonic-extraembry1.71132608
35MP0003566_abnormal_cell_adhesion1.65590615
36MP0001348_abnormal_lacrimal_gland1.65081397
37MP0002877_abnormal_melanocyte_morpholog1.64231270
38MP0002080_prenatal_lethality1.59979438
39MP0004858_abnormal_nervous_system1.59543281
40MP0001849_ear_inflammation1.57811937
41MP0000733_abnormal_muscle_development1.56160941
42MP0003283_abnormal_digestive_organ1.54435521
43MP0010030_abnormal_orbit_morphology1.52969736
44MP0009278_abnormal_bone_marrow1.52285194
45MP0008961_abnormal_basal_metabolism1.50377451
46MP0008007_abnormal_cellular_replicative1.49410852
47MP0003119_abnormal_digestive_system1.45343936
48MP0003567_abnormal_fetal_cardiomyocyte1.41738635
49MP0009672_abnormal_birth_weight1.40269901
50MP0001661_extended_life_span1.40064091
51MP0003115_abnormal_respiratory_system1.39495988
52MP0004264_abnormal_extraembryonic_tissu1.39393150
53MP0009703_decreased_birth_body1.38034788
54MP0001293_anophthalmia1.37882660
55MP0000428_abnormal_craniofacial_morphol1.36733914
56MP0008438_abnormal_cutaneous_collagen1.35553098
57MP0004233_abnormal_muscle_weight1.33247512
58MP0005023_abnormal_wound_healing1.30428499
59MP0001915_intracranial_hemorrhage1.26126356
60MP0005187_abnormal_penis_morphology1.22553920
61MP0008058_abnormal_DNA_repair1.19888152
62MP0002092_abnormal_eye_morphology1.19701187
63MP0008260_abnormal_autophagy1.17846484
64MP0002697_abnormal_eye_size1.17619601
65MP0003453_abnormal_keratinocyte_physiol1.17482061
66MP0002006_tumorigenesis1.15100225
67MP0002925_abnormal_cardiovascular_devel1.15008366
68MP0003763_abnormal_thymus_physiology1.12372994
69MP0001346_abnormal_lacrimal_gland1.11347455
70MP0003935_abnormal_craniofacial_develop1.10115355
71MP0006054_spinal_hemorrhage1.08656496
72MP0008932_abnormal_embryonic_tissue1.08196177
73MP0002796_impaired_skin_barrier1.07888992
74MP0002249_abnormal_larynx_morphology1.06695911
75MP0002653_abnormal_ependyma_morphology1.04371516
76MP0002060_abnormal_skin_morphology1.04092139
77MP0004272_abnormal_basement_membrane1.03378891
78MP0000703_abnormal_thymus_morphology1.02811088
79MP0004185_abnormal_adipocyte_glucose1.02314674
80MP0005257_abnormal_intraocular_pressure1.00835516
81MP0005501_abnormal_skin_physiology0.99197273
82MP0008877_abnormal_DNA_methylation0.98998620
83MP0003091_abnormal_cell_migration0.95795465
84MP0004087_abnormal_muscle_fiber0.95662130
85MP0000313_abnormal_cell_death0.94595597
86MP0000371_diluted_coat_color0.93067079
87MP0003315_abnormal_perineum_morphology0.92971770
88MP0000678_abnormal_parathyroid_gland0.92568870
89MP0002019_abnormal_tumor_incidence0.92516570
90MP0000759_abnormal_skeletal_muscle0.91688010
91MP0002111_abnormal_tail_morphology0.90040839
92MP0000266_abnormal_heart_morphology0.88935458
93MP0010630_abnormal_cardiac_muscle0.88342205
94MP0000747_muscle_weakness0.88057454
95MP0005397_hematopoietic_system_phenotyp0.87637452
96MP0001545_abnormal_hematopoietic_system0.87637452
97MP0000490_abnormal_crypts_of0.87193535
98MP0008770_decreased_survivor_rate0.86509398
99MP0002089_abnormal_postnatal_growth/wei0.85853780
100MP0003937_abnormal_limbs/digits/tail_de0.85517679
101MP0000751_myopathy0.84865002
102MP0000003_abnormal_adipose_tissue0.84614704
103MP0000534_abnormal_ureter_morphology0.84443370
104MP0003861_abnormal_nervous_system0.83980708
105MP0005623_abnormal_meninges_morphology0.82429625
106MP0005621_abnormal_cell_physiology0.81083715
107MP0000432_abnormal_head_morphology0.80457761
108MP0003942_abnormal_urinary_system0.79263566
109MP0003943_abnormal_hepatobiliary_system0.78801335
110MP0005248_abnormal_Harderian_gland0.78757052
111MP0002166_altered_tumor_susceptibility0.77875131
112MP0000579_abnormal_nail_morphology0.77742315
113MP0001873_stomach_inflammation0.77522247
114MP0000566_synostosis0.76345657
115MP0006138_congestive_heart_failure0.74707747
116MP0001216_abnormal_epidermal_layer0.73894663
117MP0000627_abnormal_mammary_gland0.73065569
118MP0000377_abnormal_hair_follicle0.72665799
119MP0003221_abnormal_cardiomyocyte_apopto0.72237212
120MP0005384_cellular_phenotype0.72024735
121MP0004133_heterotaxia0.71933892
122MP0005375_adipose_tissue_phenotype0.70895123
123MP0001286_abnormal_eye_development0.70700718
124MP0003122_maternal_imprinting0.70521596
125MP0000477_abnormal_intestine_morphology0.69214857
126MP0005666_abnormal_adipose_tissue0.68782582
127MP0001784_abnormal_fluid_regulation0.68445569
128MP0002234_abnormal_pharynx_morphology0.67770062
129MP0010678_abnormal_skin_adnexa0.66466898
130MP0003303_peritoneal_inflammation0.65854289
131MP0002932_abnormal_joint_morphology0.64167592
132MP0002269_muscular_atrophy0.62504895
133MP0003385_abnormal_body_wall0.60056253

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.08495938
2Short 4th metacarpal (HP:0010044)3.76027249
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.76027249
4Abnormality of the astrocytes (HP:0100707)3.46511977
5Astrocytoma (HP:0009592)3.46511977
6Hyperacusis (HP:0010780)3.37556728
7Broad face (HP:0000283)3.27606968
8Abnormality of the 4th metacarpal (HP:0010012)2.93629271
9Increased nuchal translucency (HP:0010880)2.88154040
10Deviation of the thumb (HP:0009603)2.84732407
11Abnormality of the fingertips (HP:0001211)2.77357360
12Proximal placement of thumb (HP:0009623)2.77110038
13Abnormality of the distal phalanx of the thumb (HP:0009617)2.76323966
14Medulloblastoma (HP:0002885)2.75615261
15Dysmetric saccades (HP:0000641)2.74005484
16Glioma (HP:0009733)2.69417163
17Volvulus (HP:0002580)2.67338466
18Macroorchidism (HP:0000053)2.65712385
19Heterotopia (HP:0002282)2.64807907
20Pseudobulbar signs (HP:0002200)2.63893539
21Flat acetabular roof (HP:0003180)2.61587206
22Neoplasm of the oral cavity (HP:0100649)2.61035109
23Cerebral aneurysm (HP:0004944)2.57705075
24Colon cancer (HP:0003003)2.55676140
25Long eyelashes (HP:0000527)2.55316295
26Renovascular hypertension (HP:0100817)2.50590711
27Trigonocephaly (HP:0000243)2.50131895
28Asymmetry of the thorax (HP:0001555)2.47508370
29Renal duplication (HP:0000075)2.47280639
30Shallow orbits (HP:0000586)2.43173944
31Elfin facies (HP:0004428)2.35322473
32Selective tooth agenesis (HP:0001592)2.34259588
33Neoplasm of striated muscle (HP:0009728)2.33098176
34Disproportionate tall stature (HP:0001519)2.30486514
35Biliary tract neoplasm (HP:0100574)2.28421902
36Bowel diverticulosis (HP:0005222)2.26181408
37Skull defect (HP:0001362)2.25916950
38Gastrointestinal carcinoma (HP:0002672)2.25683607
39Malignant gastrointestinal tract tumors (HP:0006749)2.25683607
40Dislocated radial head (HP:0003083)2.22962864
41Abnormality of the lower motor neuron (HP:0002366)2.22432152
42Basal cell carcinoma (HP:0002671)2.22186632
43Rhabdomyosarcoma (HP:0002859)2.20335148
44Hand muscle atrophy (HP:0009130)2.18975276
45Long palpebral fissure (HP:0000637)2.18868362
46Obstructive sleep apnea (HP:0002870)2.18681785
47Abnormality of the labia minora (HP:0012880)2.16894837
48Cutis marmorata (HP:0000965)2.16670948
49Prominent nose (HP:0000448)2.16658261
50High pitched voice (HP:0001620)2.15216359
51Obsessive-compulsive behavior (HP:0000722)2.14194869
52Urethral obstruction (HP:0000796)2.12851348
53Abnormality of the calcaneus (HP:0008364)2.11382541
54Termporal pattern (HP:0011008)2.10575600
55Insidious onset (HP:0003587)2.10575600
56Increased density of long bones (HP:0006392)2.09896481
57Distal lower limb amyotrophy (HP:0008944)2.09635292
58Skin tags (HP:0010609)2.06083845
59Advanced eruption of teeth (HP:0006288)2.04061361
60Abnormality of the radial head (HP:0003995)2.04028879
61Sparse lateral eyebrow (HP:0005338)2.03846250
62Fibroma (HP:0010614)2.03835801
63Broad thumb (HP:0011304)2.02650110
64Fibrous tissue neoplasm (HP:0012316)2.02625009
65Pointed chin (HP:0000307)2.02296778
66Sandal gap (HP:0001852)2.01322526
67Insomnia (HP:0100785)1.98573991
68Vertebral arch anomaly (HP:0008438)1.97643876
69Abnormality of the phalanges of the hallux (HP:0010057)1.97642798
70Lymphangioma (HP:0100764)1.97638584
71Patellar dislocation (HP:0002999)1.97534868
72Abnormal number of incisors (HP:0011064)1.97477911
73Osteolytic defects of the phalanges of the hand (HP:0009771)1.97398012
74Osteolytic defects of the hand bones (HP:0009699)1.97398012
75Ankyloglossia (HP:0010296)1.97215566
76Overlapping toe (HP:0001845)1.96981738
77Chromosomal breakage induced by crosslinking agents (HP:0003221)1.96443691
78Enlarged penis (HP:0000040)1.96167716
79Overriding aorta (HP:0002623)1.94574602
80Increased connective tissue (HP:0009025)1.94261601
81Distal upper limb amyotrophy (HP:0007149)1.94177947
82Upper limb amyotrophy (HP:0009129)1.94177947
83Spastic diplegia (HP:0001264)1.93192015
84Subacute progressive viral hepatitis (HP:0006572)1.92474640
85Abnormality of oral frenula (HP:0000190)1.90888603
86Short nail (HP:0001799)1.90828558
87Relative macrocephaly (HP:0004482)1.88612156
88Persistence of primary teeth (HP:0006335)1.88284426
89Narrow palate (HP:0000189)1.88176647
90Hypopigmentation of the fundus (HP:0007894)1.87623905
91Ankle contracture (HP:0006466)1.87540727
92Adenoma sebaceum (HP:0009720)1.87308764
93Angiofibromas (HP:0010615)1.87308764
94Broad palm (HP:0001169)1.86970091
95Centrally nucleated skeletal muscle fibers (HP:0003687)1.86750075
96Syringomyelia (HP:0003396)1.85965650
97Spinal cord lesions (HP:0100561)1.85965650
98Deep palmar crease (HP:0006191)1.85577936
99Premature rupture of membranes (HP:0001788)1.85290103
100Abnormality of the distal phalanges of the toes (HP:0010182)1.84559165
101Chromsome breakage (HP:0040012)1.84243642
102Aneurysm (HP:0002617)1.84072002
103Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.83652740
104Rectal prolapse (HP:0002035)1.83472488
105High anterior hairline (HP:0009890)1.83120227
106Truncal obesity (HP:0001956)1.82895383
107Septate vagina (HP:0001153)1.81659170
108Missing ribs (HP:0000921)1.80792498
109Abnormality of chromosome segregation (HP:0002916)1.78439388
110Ulnar bowing (HP:0003031)1.78400536
111Abnormal foot bone ossification (HP:0010675)1.76482381
112Abnormality of the diencephalon (HP:0010662)1.76189753
113Deep philtrum (HP:0002002)1.76178037
114Cafe-au-lait spot (HP:0000957)1.75750221
115Abnormality of the anterior horn cell (HP:0006802)1.75659497
116Degeneration of anterior horn cells (HP:0002398)1.75659497
117Mitral valve prolapse (HP:0001634)1.74655156
118Low anterior hairline (HP:0000294)1.74477636
119Lower limb amyotrophy (HP:0007210)1.72298697
120Broad distal phalanx of finger (HP:0009836)1.71710695
121Supernumerary ribs (HP:0005815)1.71142454
122Smooth philtrum (HP:0000319)1.70448925
123Precocious puberty (HP:0000826)1.70109527
124Intestinal polyp (HP:0005266)1.68337354
125Short phalanx of the thumb (HP:0009660)1.68274438
126Limited elbow extension (HP:0001377)1.68182718
127Aortic aneurysm (HP:0004942)1.68161852
128Protrusio acetabuli (HP:0003179)1.67761434
129Uterine neoplasm (HP:0010784)1.67528302
130Preauricular skin tag (HP:0000384)1.67497349
131Abnormal ossification of hand bones (HP:0005921)1.67495015
132Arnold-Chiari malformation (HP:0002308)1.66463242
133Progressive muscle weakness (HP:0003323)1.66184336
134Large earlobe (HP:0009748)1.65029484
135Trismus (HP:0000211)1.65024771
136Anal stenosis (HP:0002025)1.64447788
137Hypoplastic labia majora (HP:0000059)1.64055519
13811 pairs of ribs (HP:0000878)1.63918001
139Neonatal hypoglycemia (HP:0001998)1.63145050
140Cortical dysplasia (HP:0002539)1.62602670
141Broad phalanges of the hand (HP:0009768)1.62490606
142Attention deficit hyperactivity disorder (HP:0007018)1.61914796
143Achilles tendon contracture (HP:0001771)1.61412252
144Back pain (HP:0003418)1.61329246
145Cutaneous melanoma (HP:0012056)1.60853722
146Germ cell neoplasia (HP:0100728)1.60460876
147Intestinal polyposis (HP:0200008)1.60113565
148Abnormality of the humeroradial joint (HP:0100744)1.58959222
149Spinal muscular atrophy (HP:0007269)1.58908894
150Sacral dimple (HP:0000960)1.58704445
151Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.58330243
152Uterine leiomyosarcoma (HP:0002891)1.57139098
153Leiomyosarcoma (HP:0100243)1.57139098
154Bowel incontinence (HP:0002607)1.56118301
155Abnormality of the salivary glands (HP:0010286)1.53876545
156Abnormality of the thoracic spine (HP:0100711)1.53403201
157Wormian bones (HP:0002645)1.51264035
158Premature skin wrinkling (HP:0100678)1.51138939

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.82469382
2EEF2K4.32429405
3SMG14.23013890
4MAP3K103.28047016
5PKN23.16421723
6TRIB32.98378010
7CDC72.96548588
8PRPF4B2.60794590
9BRD42.34774659
10PASK2.15081752
11NEK22.13281984
12SCYL22.01573377
13CAMK1D1.80608964
14SIK11.80285952
15RPS6KB21.70572349
16NEK11.70483491
17TTN1.70430088
18ICK1.69132624
19LATS11.64281143
20MTOR1.64149958
21ALK1.53439433
22PTK61.52022779
23CAMK1G1.50801184
24CDK41.49661569
25PDGFRA1.47672169
26TSSK61.42889311
27CDK61.40920771
28IRAK31.39211109
29RIPK11.36759491
30TTK1.33780701
31STK101.29112770
32ATR1.23616879
33TGFBR11.21500986
34FGFR21.17245538
35WEE11.14467865
36CHEK11.14366530
37KSR11.10978269
38MST1R1.09357147
39EPHA21.06097625
40PAK41.04876252
41FGFR41.04467434
42FGFR11.04270384
43FGFR31.03705929
44MAP3K81.02290756
45LRRK21.01039040
46CDK70.98051407
47FLT30.94073644
48PAK20.91575844
49ERN10.88297535
50MAPK110.85794855
51MARK20.85583677
52CDK90.85509890
53MAP4K10.85446325
54AURKB0.83683170
55ATM0.83384327
56STK30.83255098
57CDK20.82937632
58EIF2AK10.81969669
59PLK10.79570077
60MAP3K130.78261733
61BMX0.77570790
62MAP3K90.77012985
63STK40.76532756
64MAP2K30.75004147
65CHEK20.74718694
66SIK20.73897024
67TAOK10.72963214
68TYRO30.70580554
69PLK30.67807018
70MELK0.67727749
71MAP3K70.66349878
72RET0.66113024
73CSNK1D0.63625802
74PDGFRB0.63165319
75CDK10.59775610
76TAF10.58288822
77PNCK0.57475647
78WNK10.56483577
79CLK10.55132431
80BRAF0.54693593
81ERBB20.54415501
82RPS6KA40.54298905
83BUB10.54261280
84PRKDC0.54035347
85PRKD20.51156645
86AKT30.50982899
87MAPK100.50296683
88CSNK1E0.49109860
89AKT20.49097725
90MAP3K20.48619584
91PRKD30.48316685
92NEK90.47979768
93NTRK10.47935806
94PIM10.47530932
95RAF10.47450435
96PTK20.47059312
97SGK30.47048276
98CHUK0.46897945
99MAP3K140.46676843
100HIPK20.46570204
101CDK80.46024138
102MAPK140.45873658
103SIK30.45871841
104DMPK0.45716986
105TRPM70.44869906
106AURKA0.44113194
107BRSK20.43799320
108RPS6KA20.43448771
109SRPK10.42386709
110PDPK10.42373275
111ACVR1B0.40287855
112MAPKAPK30.40144506
113MAPK10.40004505
114RPS6KB10.39887045
115TAOK20.39087351
116MKNK10.38907438
117GRK60.38401195
118JAK30.37293273
119AKT10.37053259
120MET0.36473963
121GSK3B0.36190679
122RPS6KA10.36105585
123EPHB20.34538808
124KSR20.33996983
125BRSK10.32119471
126PRKAA10.31922698
127EGFR0.31167645
128LATS20.29991433
129ZAP700.29814616
130CDC42BPA0.29313341

Predicted pathways (KEGG)

RankGene SetZ-score
1One carbon pool by folate_Homo sapiens_hsa006702.75705947
2DNA replication_Homo sapiens_hsa030302.39620951
3RNA transport_Homo sapiens_hsa030132.35134425
4Lysine degradation_Homo sapiens_hsa003102.22830748
5Cell cycle_Homo sapiens_hsa041102.10754967
6Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.07852366
7Mismatch repair_Homo sapiens_hsa034302.05816219
8mRNA surveillance pathway_Homo sapiens_hsa030152.03347121
9Chronic myeloid leukemia_Homo sapiens_hsa052201.82795866
10Nitrogen metabolism_Homo sapiens_hsa009101.79990037
11* Spliceosome_Homo sapiens_hsa030401.77921888
12MicroRNAs in cancer_Homo sapiens_hsa052061.67360322
13mTOR signaling pathway_Homo sapiens_hsa041501.65673055
14Notch signaling pathway_Homo sapiens_hsa043301.52706027
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.51773938
16Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.49435863
17Adherens junction_Homo sapiens_hsa045201.47037582
18Central carbon metabolism in cancer_Homo sapiens_hsa052301.45677125
19Selenocompound metabolism_Homo sapiens_hsa004501.45017194
20Basal cell carcinoma_Homo sapiens_hsa052171.42766295
21Viral carcinogenesis_Homo sapiens_hsa052031.41928745
22Small cell lung cancer_Homo sapiens_hsa052221.38036882
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.36576734
24Base excision repair_Homo sapiens_hsa034101.34370424
25Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.33843285
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.33833776
27Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.33662980
28Colorectal cancer_Homo sapiens_hsa052101.32373640
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.32349864
30Thyroid hormone signaling pathway_Homo sapiens_hsa049191.28698382
31Non-small cell lung cancer_Homo sapiens_hsa052231.28431592
32HTLV-I infection_Homo sapiens_hsa051661.27450419
33Pentose phosphate pathway_Homo sapiens_hsa000301.27058478
34Endometrial cancer_Homo sapiens_hsa052131.26541229
35Proteoglycans in cancer_Homo sapiens_hsa052051.21978948
36Systemic lupus erythematosus_Homo sapiens_hsa053221.21751760
37Hippo signaling pathway_Homo sapiens_hsa043901.20609504
38Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.19749293
39Biosynthesis of amino acids_Homo sapiens_hsa012301.12309435
40Inositol phosphate metabolism_Homo sapiens_hsa005621.08319307
41Phosphatidylinositol signaling system_Homo sapiens_hsa040701.08251855
42Viral myocarditis_Homo sapiens_hsa054161.05559675
43Non-homologous end-joining_Homo sapiens_hsa034501.03240793
44Bladder cancer_Homo sapiens_hsa052191.02973967
45Neurotrophin signaling pathway_Homo sapiens_hsa047220.99583195
46Glioma_Homo sapiens_hsa052140.99213847
47Insulin resistance_Homo sapiens_hsa049310.99142440
48p53 signaling pathway_Homo sapiens_hsa041150.98704448
49Fatty acid biosynthesis_Homo sapiens_hsa000610.97122779
50Prion diseases_Homo sapiens_hsa050200.97008710
51Thyroid cancer_Homo sapiens_hsa052160.96025159
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.95333267
53Choline metabolism in cancer_Homo sapiens_hsa052310.93735036
54Pancreatic cancer_Homo sapiens_hsa052120.93283473
55Oocyte meiosis_Homo sapiens_hsa041140.92996335
56Antigen processing and presentation_Homo sapiens_hsa046120.92887150
57Acute myeloid leukemia_Homo sapiens_hsa052210.92691672
58Dorso-ventral axis formation_Homo sapiens_hsa043200.92299623
592-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.91734492
60Focal adhesion_Homo sapiens_hsa045100.88250642
61Nucleotide excision repair_Homo sapiens_hsa034200.86550845
62Prostate cancer_Homo sapiens_hsa052150.85857869
63Hedgehog signaling pathway_Homo sapiens_hsa043400.85273806
64Cyanoamino acid metabolism_Homo sapiens_hsa004600.85119154
65AMPK signaling pathway_Homo sapiens_hsa041520.85090899
66Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.84652110
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.83624530
68Long-term potentiation_Homo sapiens_hsa047200.81870030
69RNA degradation_Homo sapiens_hsa030180.81773789
70Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.81256696
71Insulin signaling pathway_Homo sapiens_hsa049100.80553066
72Renal cell carcinoma_Homo sapiens_hsa052110.78119297
73GnRH signaling pathway_Homo sapiens_hsa049120.77117691
74Type II diabetes mellitus_Homo sapiens_hsa049300.76047291
75Pathways in cancer_Homo sapiens_hsa052000.73942796
76TGF-beta signaling pathway_Homo sapiens_hsa043500.73814019
77Hepatitis B_Homo sapiens_hsa051610.72970934
78Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71970664
79Glucagon signaling pathway_Homo sapiens_hsa049220.71146644
80Fructose and mannose metabolism_Homo sapiens_hsa000510.71020133
81Other glycan degradation_Homo sapiens_hsa005110.70411854
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.70339140
83B cell receptor signaling pathway_Homo sapiens_hsa046620.70295440
84Epstein-Barr virus infection_Homo sapiens_hsa051690.70133639
85Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.69423045
86Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69367812
87FoxO signaling pathway_Homo sapiens_hsa040680.68338959
88Fanconi anemia pathway_Homo sapiens_hsa034600.67634480
89Herpes simplex infection_Homo sapiens_hsa051680.65673779
90Estrogen signaling pathway_Homo sapiens_hsa049150.65406058
91VEGF signaling pathway_Homo sapiens_hsa043700.64691961
92HIF-1 signaling pathway_Homo sapiens_hsa040660.64427685
93Prolactin signaling pathway_Homo sapiens_hsa049170.63513354
94Alcoholism_Homo sapiens_hsa050340.63369979
95AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62595214
96Thyroid hormone synthesis_Homo sapiens_hsa049180.62298395
97Melanoma_Homo sapiens_hsa052180.61548827
98Melanogenesis_Homo sapiens_hsa049160.61126824
99Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.61052768
100Wnt signaling pathway_Homo sapiens_hsa043100.60212737
101T cell receptor signaling pathway_Homo sapiens_hsa046600.58955127
102Hepatitis C_Homo sapiens_hsa051600.58856865
103Arginine biosynthesis_Homo sapiens_hsa002200.58657610
104Carbon metabolism_Homo sapiens_hsa012000.58290076
105Leukocyte transendothelial migration_Homo sapiens_hsa046700.57075430
106Tight junction_Homo sapiens_hsa045300.54115108
107Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54010456
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.53241365
109Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.53141419
110Vitamin B6 metabolism_Homo sapiens_hsa007500.52804684
111Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52151975
112ECM-receptor interaction_Homo sapiens_hsa045120.51103276
113Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50627859
114Apoptosis_Homo sapiens_hsa042100.50475457
115Gap junction_Homo sapiens_hsa045400.49337858
116ErbB signaling pathway_Homo sapiens_hsa040120.47868566
117Homologous recombination_Homo sapiens_hsa034400.47794336
118Cysteine and methionine metabolism_Homo sapiens_hsa002700.47485788
119Toxoplasmosis_Homo sapiens_hsa051450.46807612
120Platelet activation_Homo sapiens_hsa046110.43854777
121Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.41041607
122Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.40087444
123Adipocytokine signaling pathway_Homo sapiens_hsa049200.39779064
124N-Glycan biosynthesis_Homo sapiens_hsa005100.39569795
125Drug metabolism - other enzymes_Homo sapiens_hsa009830.39108027

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