PRPH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cytoskeletal protein found in neurons of the peripheral nervous system. The encoded protein is a type III intermediate filament protein with homology to other cytoskeletal proteins such as desmin, and is a different protein that the peripherin found in photoreceptors. Mutations in this gene have been associated with susceptibility to amyotrophic lateral sclerosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of temperature stimulus (GO:0016048)7.44662640
2peripheral nervous system neuron development (GO:0048935)7.05750064
3detection of temperature stimulus involved in sensory perception (GO:0050961)7.04797281
4detection of temperature stimulus involved in sensory perception of pain (GO:0050965)7.04797281
5negative regulation of calcium ion transport into cytosol (GO:0010523)6.68083397
6cell migration in hindbrain (GO:0021535)6.63607649
7negative regulation of dendrite morphogenesis (GO:0050774)6.56754668
8neurofilament cytoskeleton organization (GO:0060052)6.48752186
9pyrimidine nucleobase catabolic process (GO:0006208)6.26529524
10axonemal dynein complex assembly (GO:0070286)5.54024016
11glucose 6-phosphate metabolic process (GO:0051156)5.35827979
12negative regulation of amyloid precursor protein catabolic process (GO:1902992)5.21010046
13enteric nervous system development (GO:0048484)5.20623397
14synaptic transmission, cholinergic (GO:0007271)5.14394972
15neuronal action potential (GO:0019228)5.12922918
16response to pain (GO:0048265)5.02422573
17negative regulation of microtubule polymerization (GO:0031115)4.92072247
18positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.90839220
19nucleobase catabolic process (GO:0046113)4.86119216
20regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.67725206
21negative regulation of heart rate (GO:0010459)4.59429763
22cranial nerve morphogenesis (GO:0021602)4.52619666
23neuronal action potential propagation (GO:0019227)4.49461274
24proline transport (GO:0015824)4.43563798
25neurotransmitter biosynthetic process (GO:0042136)4.40325381
26sympathetic nervous system development (GO:0048485)4.37944293
27positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.37488711
28behavioral response to nicotine (GO:0035095)4.37215135
29negative regulation of dendrite development (GO:2000171)4.31849615
30cilium or flagellum-dependent cell motility (GO:0001539)4.31803265
31neuron projection extension involved in neuron projection guidance (GO:1902284)4.30813142
32axon extension involved in axon guidance (GO:0048846)4.30813142
33response to water (GO:0009415)4.26179314
34behavioral response to pain (GO:0048266)4.25204150
35cranial nerve development (GO:0021545)4.23170703
36ganglion development (GO:0061548)4.18886965
37negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)4.12568242
38membrane depolarization during action potential (GO:0086010)4.07980343
39auditory behavior (GO:0031223)4.07069145
40cilium movement (GO:0003341)3.99449013
41regulation of amyloid precursor protein catabolic process (GO:1902991)3.87648141
42synaptic vesicle maturation (GO:0016188)3.85701076
43axon cargo transport (GO:0008088)3.83109142
44regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.82635814
45regulation of short-term neuronal synaptic plasticity (GO:0048172)3.81580316
46motile cilium assembly (GO:0044458)3.80657929
47neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.79799782
48chaperone-mediated protein transport (GO:0072321)3.75052181
49positive regulation of synaptic transmission, GABAergic (GO:0032230)3.73230636
50innervation (GO:0060384)3.68796484
51retinal ganglion cell axon guidance (GO:0031290)3.67505524
52negative regulation of phosphoprotein phosphatase activity (GO:0032515)3.65234709
53membrane budding (GO:0006900)3.64027747
54detection of mechanical stimulus involved in sensory perception (GO:0050974)3.64000832
55regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.63770668
56positive regulation of potassium ion transmembrane transport (GO:1901381)3.62663902
57negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.61396052
58epithelial cilium movement (GO:0003351)3.60580402
59regulation of NFAT protein import into nucleus (GO:0051532)3.60115196
60urinary tract smooth muscle contraction (GO:0014848)3.58760139
61calcium-mediated signaling using intracellular calcium source (GO:0035584)3.58426599
62neuromuscular synaptic transmission (GO:0007274)3.57059529
63negative regulation of cation channel activity (GO:2001258)3.53043015
64axonal fasciculation (GO:0007413)3.51587356
65establishment of nucleus localization (GO:0040023)3.49710896
66glutamate secretion (GO:0014047)3.48394483
67cartilage morphogenesis (GO:0060536)3.46934034
68cell communication involved in cardiac conduction (GO:0086065)3.45790916
69regulation of synaptic vesicle exocytosis (GO:2000300)3.43751488
70establishment of mitochondrion localization (GO:0051654)3.43550273
71plasma membrane repair (GO:0001778)3.43390427
72layer formation in cerebral cortex (GO:0021819)3.40232193
73negative regulation of norepinephrine secretion (GO:0010700)3.39805920
74protein maturation by protein folding (GO:0022417)3.37710363
75cellular response to nicotine (GO:0071316)3.36060859
76axon extension (GO:0048675)3.34879489
77regulation of histone phosphorylation (GO:0033127)3.32795287
78epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.31569477
79nerve development (GO:0021675)3.31449293
80coronary vasculature morphogenesis (GO:0060977)3.25798437
81sensory perception of pain (GO:0019233)3.24468711
82positive regulation of cell size (GO:0045793)3.23612186
83respiratory system process (GO:0003016)3.21596280
84membrane repolarization (GO:0086009)3.18115772
85positive regulation of growth hormone secretion (GO:0060124)3.16913253
86synaptic vesicle exocytosis (GO:0016079)3.16351329
87action potential (GO:0001508)3.16269845
88neuron recognition (GO:0008038)3.15091612
89adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.13483175
90central nervous system neuron axonogenesis (GO:0021955)3.12115195
91neuron fate specification (GO:0048665)3.11674635
92negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.10688844
93neuronal ion channel clustering (GO:0045161)3.10543244
94mitochondrion transport along microtubule (GO:0047497)3.09922946
95establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.09922946
96potassium ion export (GO:0071435)3.08306636
97regulation of cardioblast proliferation (GO:0003264)3.07391473
98regulation of secondary heart field cardioblast proliferation (GO:0003266)3.07391473
99neuron cell-cell adhesion (GO:0007158)3.07062439
100substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.01432984
101substrate-independent telencephalic tangential migration (GO:0021826)3.01432984
102alanine transport (GO:0032328)3.01253962
103axon development (GO:0061564)3.00528561
104presynaptic membrane organization (GO:0097090)3.00460979
105mechanosensory behavior (GO:0007638)3.00339859
106dopaminergic neuron differentiation (GO:0071542)3.00012113
107regulation of growth hormone secretion (GO:0060123)2.99815763
108multicellular organismal response to stress (GO:0033555)2.99792602
109neurotransmitter secretion (GO:0007269)2.99202763
110peristalsis (GO:0030432)2.99005514
111adenosine receptor signaling pathway (GO:0001973)2.98279446
112neurotransmitter metabolic process (GO:0042133)2.96925134
113bundle of His cell to Purkinje myocyte communication (GO:0086069)2.96848206
114central nervous system projection neuron axonogenesis (GO:0021952)2.96444627
115sequestering of actin monomers (GO:0042989)2.94827830
116negative regulation of striated muscle cell apoptotic process (GO:0010664)2.91936540
117embryonic body morphogenesis (GO:0010172)2.90560368
118regulation of dopamine secretion (GO:0014059)2.89713445
119cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.89285493
120regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.88951362
121negative regulation of cytosolic calcium ion concentration (GO:0051481)2.88861329
122positive regulation of glomerulus development (GO:0090193)2.88543341
123skeletal muscle organ development (GO:0060538)2.88015980
124regulation of respiratory gaseous exchange (GO:0043576)2.87979465
125regulation of synaptic vesicle transport (GO:1902803)2.87179307
126suckling behavior (GO:0001967)2.86770138
127body morphogenesis (GO:0010171)2.86325906
128positive regulation of potassium ion transport (GO:0043268)2.84680973
129regulation of cell communication by electrical coupling (GO:0010649)2.83236455
130positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.82333185
131regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.82179060
132apical protein localization (GO:0045176)2.80949307
133embryonic skeletal system morphogenesis (GO:0048704)2.80503350
134neuron projection extension (GO:1990138)2.79724717
135positive regulation of muscle hypertrophy (GO:0014742)2.79436735
136positive regulation of cardiac muscle hypertrophy (GO:0010613)2.79436735
137axon regeneration (GO:0031103)2.78954968
138regulation of respiratory system process (GO:0044065)2.77105854
139regulation of cell maturation (GO:1903429)2.76375420
140acrosome reaction (GO:0007340)2.75939291
141regulation of heart morphogenesis (GO:2000826)2.75233485
142intermediate filament organization (GO:0045109)2.75087979
143sodium ion export (GO:0071436)2.74985308
144response to auditory stimulus (GO:0010996)2.74925793
145microtubule severing (GO:0051013)2.74508608
146negative regulation of protein polymerization (GO:0032272)2.73469660
147left/right pattern formation (GO:0060972)2.72905021
148regulation of protein kinase A signaling (GO:0010738)2.72384236
149mating behavior (GO:0007617)2.72356477
150organelle transport along microtubule (GO:0072384)2.71689052
151negative regulation of calcium ion transmembrane transport (GO:1903170)2.70666334
152negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.70666334
153cellular potassium ion homeostasis (GO:0030007)2.70110164
154cerebellar Purkinje cell differentiation (GO:0021702)2.69363733
155regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.67898189
156cell communication by electrical coupling (GO:0010644)2.66430025
157thyroid gland development (GO:0030878)2.66236220
158regulation of potassium ion transmembrane transporter activity (GO:1901016)2.65663626
159locomotory exploration behavior (GO:0035641)2.64155764
160dopamine receptor signaling pathway (GO:0007212)2.61186112
161outflow tract septum morphogenesis (GO:0003148)2.59835290
162outer ear morphogenesis (GO:0042473)2.59554566
163planar cell polarity pathway involved in neural tube closure (GO:0090179)2.59265515
164synapse assembly (GO:0007416)2.58362044
165protein localization to synapse (GO:0035418)2.53887557
166lung epithelium development (GO:0060428)2.53451678
167microtubule-based movement (GO:0007018)2.50500324
168regulation of synapse structural plasticity (GO:0051823)2.50443261
169endocardial cushion morphogenesis (GO:0003203)2.50243318
170dendrite morphogenesis (GO:0048813)2.49119291
171establishment of monopolar cell polarity (GO:0061162)2.47023169
172establishment or maintenance of monopolar cell polarity (GO:0061339)2.47023169
173dendritic spine morphogenesis (GO:0060997)2.46123385

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.83203603
2* JARID2_20075857_ChIP-Seq_MESCs_Mouse3.19141149
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.05115678
4RNF2_18974828_ChIP-Seq_MESCs_Mouse3.04032391
5EZH2_18974828_ChIP-Seq_MESCs_Mouse3.04032391
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.79162034
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.77495108
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.76487315
9TAF15_26573619_Chip-Seq_HEK293_Human2.71866380
10NR3C1_23031785_ChIP-Seq_PC12_Mouse2.71320247
11ZNF263_19887448_ChIP-Seq_K562_Human2.68990614
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.65134741
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.57903434
14CBX2_27304074_Chip-Seq_ESCs_Mouse2.55407248
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.55348688
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.55156121
17* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.54159529
18* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.51562092
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.36409996
20REST_21632747_ChIP-Seq_MESCs_Mouse2.36062869
21ESR2_21235772_ChIP-Seq_MCF-7_Human2.32026183
22BMI1_23680149_ChIP-Seq_NPCS_Mouse2.26032088
23* EZH2_27294783_Chip-Seq_ESCs_Mouse2.23790932
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.22674408
25REST_18959480_ChIP-ChIP_MESCs_Mouse2.20210516
26EED_16625203_ChIP-ChIP_MESCs_Mouse2.16798539
27* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.10159807
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.05712191
29ERG_21242973_ChIP-ChIP_JURKAT_Human2.02429087
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.01306609
31ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.98097892
32RNF2_27304074_Chip-Seq_ESCs_Mouse1.93213868
33CDX2_19796622_ChIP-Seq_MESCs_Mouse1.91353433
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.87363948
35EGR1_19032775_ChIP-ChIP_M12_Human1.79159191
36PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.61494712
37* CTCF_27219007_Chip-Seq_Bcells_Human1.59703223
38ZFP281_18757296_ChIP-ChIP_E14_Mouse1.57852311
39* KDM2B_26808549_Chip-Seq_K562_Human1.57827250
40GBX2_23144817_ChIP-Seq_PC3_Human1.56228838
41EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.51338016
42POU5F1_16153702_ChIP-ChIP_HESCs_Human1.50331033
43* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50185792
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47030849
45RARB_27405468_Chip-Seq_BRAIN_Mouse1.46806538
46TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45401610
47KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.42840373
48KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.42840373
49KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.42840373
50TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.42800199
51OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.40523054
52IKZF1_21737484_ChIP-ChIP_HCT116_Human1.38784961
53BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.38557834
54NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.35106848
55THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.34457397
56SMAD4_21799915_ChIP-Seq_A2780_Human1.34003859
57AHR_22903824_ChIP-Seq_MCF-7_Human1.33541280
58TET1_21490601_ChIP-Seq_MESCs_Mouse1.30219633
59TP53_20018659_ChIP-ChIP_R1E_Mouse1.30089601
60ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.28938306
61CTBP2_25329375_ChIP-Seq_LNCAP_Human1.27802636
62* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.25190269
63TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24526628
64RARG_19884340_ChIP-ChIP_MEFs_Mouse1.23780738
65WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.22768290
66WT1_19549856_ChIP-ChIP_CCG9911_Human1.22722869
67TP63_19390658_ChIP-ChIP_HaCaT_Human1.22399960
68RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.21409657
69CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.19999015
70SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.18356606
71KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.17273454
72FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.15861777
73P300_19829295_ChIP-Seq_ESCs_Human1.15646717
74TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13148732
75DNAJC2_21179169_ChIP-ChIP_NT2_Human1.10872598
76DROSHA_22980978_ChIP-Seq_HELA_Human1.09317821
77CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09010330
78TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06737475
79POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06737475
80* RING1B_27294783_Chip-Seq_ESCs_Mouse1.06627786
81* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02898140
82* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.02467379
83SMAD3_21741376_ChIP-Seq_ESCs_Human1.01927949
84ZNF274_21170338_ChIP-Seq_K562_Hela1.01742954
85PRDM14_20953172_ChIP-Seq_ESCs_Human1.01156951
86ISL1_27105846_Chip-Seq_CPCs_Mouse1.00799192
87* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.99994886
88GATA1_26923725_Chip-Seq_HPCs_Mouse0.99060104
89CTBP1_25329375_ChIP-Seq_LNCAP_Human0.99016689
90OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98442010
91RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.98132159
92CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.94164721
93SMAD3_21741376_ChIP-Seq_EPCs_Human0.92665647
94SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92104403
95SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92077959
96SOX2_21211035_ChIP-Seq_LN229_Gbm0.91992589
97TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.91827587
98* SA1_27219007_Chip-Seq_ERYTHROID_Human0.91514620
99* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89906159
100KDM2B_26808549_Chip-Seq_SUP-B15_Human0.89740388
101ARNT_22903824_ChIP-Seq_MCF-7_Human0.89154487
102PIAS1_25552417_ChIP-Seq_VCAP_Human0.88807412
103* SMAD4_21741376_ChIP-Seq_HESCs_Human0.88301405
104CDX2_20551321_ChIP-Seq_CACO-2_Human0.87630420
105ESR1_20079471_ChIP-ChIP_T-47D_Human0.86983387
106RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.86956648
107LXR_22292898_ChIP-Seq_THP-1_Human0.85973226
108SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.85162207
109SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84997012
110TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.84482742
111STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.83617290
112POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.82693116
113LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82438009
114* RING1B_27294783_Chip-Seq_NPCs_Mouse0.81689804
115* SOX2_19829295_ChIP-Seq_ESCs_Human0.81660303
116* NANOG_19829295_ChIP-Seq_ESCs_Human0.81660303
117TBL1_22424771_ChIP-Seq_293T_Human0.81384014
118RNF2_27304074_Chip-Seq_NSC_Mouse0.81023794
119AR_25329375_ChIP-Seq_VCAP_Human0.80987829
120SMAD_19615063_ChIP-ChIP_OVARY_Human0.80927155
121ZNF217_24962896_ChIP-Seq_MCF-7_Human0.80786208
122* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.80122382
123SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.79843444
124ZFP57_27257070_Chip-Seq_ESCs_Mouse0.79307697
125YAP1_20516196_ChIP-Seq_MESCs_Mouse0.79039796
126* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.78968281
127WT1_25993318_ChIP-Seq_PODOCYTE_Human0.78894013
128PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.78172060
129AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.77894417
130VDR_22108803_ChIP-Seq_LS180_Human0.77320965
131SOX2_16153702_ChIP-ChIP_HESCs_Human0.76127896
132IGF1R_20145208_ChIP-Seq_DFB_Human0.76117198
133MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.75424832
134AR_19668381_ChIP-Seq_PC3_Human0.74677427
135DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.74645733
136HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.73188177

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002735_abnormal_chemical_nociception6.57568849
2MP0001968_abnormal_touch/_nociception5.87384186
3MP0002736_abnormal_nociception_after5.12442305
4MP0004858_abnormal_nervous_system4.85471358
5MP0004270_analgesia4.38190915
6MP0002733_abnormal_thermal_nociception4.25463781
7MP0006276_abnormal_autonomic_nervous4.08828483
8MP0002734_abnormal_mechanical_nocicepti3.82274875
9MP0001970_abnormal_pain_threshold3.65083321
10MP0001986_abnormal_taste_sensitivity3.61438514
11MP0002751_abnormal_autonomic_nervous2.87921671
12MP0004859_abnormal_synaptic_plasticity2.75356194
13MP0003183_abnormal_peptide_metabolism2.71626433
14MP0002184_abnormal_innervation2.32368003
15MP0002163_abnormal_gland_morphology2.19384868
16MP0005083_abnormal_biliary_tract2.04705436
17MP0002638_abnormal_pupillary_reflex2.03916406
18MP0002249_abnormal_larynx_morphology1.99505237
19MP0002272_abnormal_nervous_system1.98529062
20MP0010386_abnormal_urinary_bladder1.97301005
21MP0003635_abnormal_synaptic_transmissio1.93927822
22MP0005409_darkened_coat_color1.84836706
23MP0002067_abnormal_sensory_capabilities1.82562280
24MP0002822_catalepsy1.77900439
25MP0000955_abnormal_spinal_cord1.71795957
26MP0003329_amyloid_beta_deposits1.68775564
27MP0000372_irregular_coat_pigmentation1.65807039
28MP0006072_abnormal_retinal_apoptosis1.64475082
29MP0003880_abnormal_central_pattern1.63765701
30MP0001502_abnormal_circadian_rhythm1.62136124
31MP0004811_abnormal_neuron_physiology1.57542189
32MP0009250_abnormal_appendicular_skeleto1.52409233
33MP0001440_abnormal_grooming_behavior1.51826607
34MP0001270_distended_abdomen1.49819621
35MP0005187_abnormal_penis_morphology1.45793560
36MP0005423_abnormal_somatic_nervous1.45568615
37MP0001348_abnormal_lacrimal_gland1.43417640
38MP0009745_abnormal_behavioral_response1.43342611
39MP0002932_abnormal_joint_morphology1.41811810
40MP0002064_seizures1.40438804
41MP0009379_abnormal_foot_pigmentation1.39229559
42MP0005253_abnormal_eye_physiology1.32517772
43MP0000538_abnormal_urinary_bladder1.32402502
44MP0000751_myopathy1.31698376
45MP0003567_abnormal_fetal_cardiomyocyte1.30431455
46MP0003861_abnormal_nervous_system1.29043166
47MP0000537_abnormal_urethra_morphology1.28149087
48MP0002063_abnormal_learning/memory/cond1.27435246
49MP0002572_abnormal_emotion/affect_behav1.24656744
50MP0000049_abnormal_middle_ear1.23387041
51MP0003656_abnormal_erythrocyte_physiolo1.22321703
52MP0002653_abnormal_ependyma_morphology1.20072447
53MP0000566_synostosis1.19306958
54MP0009046_muscle_twitch1.18502350
55MP0000778_abnormal_nervous_system1.17374003
56MP0008260_abnormal_autophagy1.16878060
57MP0003283_abnormal_digestive_organ1.16003447
58MP0005379_endocrine/exocrine_gland_phen1.15496031
59* MP0002882_abnormal_neuron_morphology1.14480649
60MP0005248_abnormal_Harderian_gland1.09346036
61MP0003115_abnormal_respiratory_system1.08929341
62MP0005394_taste/olfaction_phenotype1.08683310
63MP0005499_abnormal_olfactory_system1.08683310
64MP0002152_abnormal_brain_morphology1.07155321
65MP0002697_abnormal_eye_size1.06078319
66MP0001177_atelectasis1.03926268
67MP0002909_abnormal_adrenal_gland1.03281958
68MP0002233_abnormal_nose_morphology1.02950642
69MP0000462_abnormal_digestive_system1.02005782
70MP0002114_abnormal_axial_skeleton0.99116794
71MP0005391_vision/eye_phenotype0.98130390
72MP0001299_abnormal_eye_distance/0.97807640
73MP0010030_abnormal_orbit_morphology0.97711454
74MP0000534_abnormal_ureter_morphology0.97503014
75MP0005377_hearing/vestibular/ear_phenot0.96660729
76MP0003878_abnormal_ear_physiology0.96660729
77MP0000749_muscle_degeneration0.96267529
78MP0003045_fibrosis0.95966563
79MP0005197_abnormal_uvea_morphology0.94878835
80MP0002081_perinatal_lethality0.94785915
81MP0001905_abnormal_dopamine_level0.94288291
82MP0002009_preneoplasia0.94040589
83MP0004924_abnormal_behavior0.93255783
84MP0005386_behavior/neurological_phenoty0.93255783
85MP0008789_abnormal_olfactory_epithelium0.93013849
86MP0000516_abnormal_urinary_system0.92910940
87MP0005367_renal/urinary_system_phenotyp0.92910940
88MP0002116_abnormal_craniofacial_bone0.92797320
89MP0003942_abnormal_urinary_system0.92685191
90MP0001943_abnormal_respiration0.92127577
91MP0001501_abnormal_sleep_pattern0.91509479
92MP0002229_neurodegeneration0.91254427
93MP0003385_abnormal_body_wall0.91011978
94MP0002127_abnormal_cardiovascular_syste0.90009653
95* MP0002752_abnormal_somatic_nervous0.89123179
96MP0004883_abnormal_blood_vessel0.87768210
97MP0002102_abnormal_ear_morphology0.85884629
98MP0000604_amyloidosis0.85864001
99MP0003935_abnormal_craniofacial_develop0.85473066
100MP0002066_abnormal_motor_capabilities/c0.85091342
101MP0001664_abnormal_digestion0.84100634
102MP0003937_abnormal_limbs/digits/tail_de0.83985551
103MP0001346_abnormal_lacrimal_gland0.82897308
104MP0000747_muscle_weakness0.82509729
105MP0008874_decreased_physiological_sensi0.82405164
106MP0001286_abnormal_eye_development0.81216030
107MP0004782_abnormal_surfactant_physiolog0.81187379
108MP0003633_abnormal_nervous_system0.81129761
109MP0008569_lethality_at_weaning0.81089056
110MP0002557_abnormal_social/conspecific_i0.80879875
111MP0000631_abnormal_neuroendocrine_gland0.79418903
112MP0005257_abnormal_intraocular_pressure0.77039261
113MP0003698_abnormal_male_reproductive0.76709323
114MP0003948_abnormal_gas_homeostasis0.76302362
115MP0003634_abnormal_glial_cell0.76159212
116MP0003011_delayed_dark_adaptation0.74510010
117MP0010770_preweaning_lethality0.74506332
118MP0002082_postnatal_lethality0.74506332
119MP0002160_abnormal_reproductive_system0.72062080
120MP0008872_abnormal_physiological_respon0.71897148
121MP0004142_abnormal_muscle_tone0.71166419
122MP0001756_abnormal_urination0.70560362
123MP0002837_dystrophic_cardiac_calcinosis0.70459764
124MP0000681_abnormal_thyroid_gland0.68205872
125MP0008775_abnormal_heart_ventricle0.67654856
126MP0003646_muscle_fatigue0.67561643
127MP0003631_nervous_system_phenotype0.66571968
128MP0004145_abnormal_muscle_electrophysio0.64279726
129MP0009780_abnormal_chondrocyte_physiolo0.62309480
130MP0004036_abnormal_muscle_relaxation0.61422147
131MP0005645_abnormal_hypothalamus_physiol0.61256833
132MP0001984_abnormal_olfaction0.60824437
133MP0003868_abnormal_feces_composition0.57217137
134MP0004085_abnormal_heartbeat0.56166682
135MP0000759_abnormal_skeletal_muscle0.55177367
136MP0008961_abnormal_basal_metabolism0.52224800
137MP0001486_abnormal_startle_reflex0.50182277
138MP0000613_abnormal_salivary_gland0.50161015
139MP0005535_abnormal_body_temperature0.49873996
140MP0001188_hyperpigmentation0.48835947
141MP0002972_abnormal_cardiac_muscle0.48433380
142MP0010771_integument_phenotype0.47657448
143MP0003122_maternal_imprinting0.46624892
144MP0002269_muscular_atrophy0.45491860
145MP0004742_abnormal_vestibular_system0.44268572
146MP0000579_abnormal_nail_morphology0.43595018
147MP0004084_abnormal_cardiac_muscle0.43118842
148MP0001529_abnormal_vocalization0.42413952
149MP0000230_abnormal_systemic_arterial0.42120999
150MP0002069_abnormal_eating/drinking_beha0.42116174

Predicted human phenotypes

RankGene SetZ-score
1Decreased number of large peripheral myelinated nerve fibers (HP:0003387)6.25078368
2Myokymia (HP:0002411)6.23888688
3Cholecystitis (HP:0001082)6.14766278
4Abnormal gallbladder physiology (HP:0012438)6.14766278
5Ulnar claw (HP:0001178)6.13351786
6Peripheral hypomyelination (HP:0007182)5.94278832
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.57674751
8Pheochromocytoma (HP:0002666)5.18934221
9Dynein arm defect of respiratory motile cilia (HP:0012255)4.97659713
10Absent/shortened dynein arms (HP:0200106)4.97659713
11Abnormal respiratory epithelium morphology (HP:0012253)4.90957982
12Abnormal respiratory motile cilium morphology (HP:0005938)4.90957982
13Abnormal respiratory motile cilium physiology (HP:0012261)4.84678770
14Action tremor (HP:0002345)4.83575611
15Abnormal ciliary motility (HP:0012262)4.76758253
16Neuroendocrine neoplasm (HP:0100634)4.67595651
17Thoracolumbar scoliosis (HP:0002944)4.44132247
18Rhinitis (HP:0012384)4.41743753
19Hypothermia (HP:0002045)4.04989945
20Distal arthrogryposis (HP:0005684)3.96067830
21Decreased number of peripheral myelinated nerve fibers (HP:0003380)3.94667879
22Intestinal atresia (HP:0011100)3.88699190
23Abnormality of pain sensation (HP:0010832)3.88481976
24Impaired pain sensation (HP:0007328)3.88481976
25Buphthalmos (HP:0000557)3.85264013
26Insidious onset (HP:0003587)3.67434038
27Termporal pattern (HP:0011008)3.67434038
28Failure to thrive in infancy (HP:0001531)3.48132921
29Hypercortisolism (HP:0001578)3.35720155
30Dysautonomia (HP:0002459)3.35570829
31Segmental peripheral demyelination/remyelination (HP:0003481)3.34195509
32Submucous cleft hard palate (HP:0000176)3.33942769
33Myotonia (HP:0002486)3.31910547
34Abnormality of the aortic arch (HP:0012303)3.30631408
35Abnormality of the phalanges of the 2nd finger (HP:0009541)3.30031453
36Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.29378622
37Bicornuate uterus (HP:0000813)3.18516376
38Decreased motor nerve conduction velocity (HP:0003431)3.08106545
39Neoplasm of the peripheral nervous system (HP:0100007)3.07509856
40Esophageal atresia (HP:0002032)3.05878886
41Chin dimple (HP:0010751)3.03826898
42Foot dorsiflexor weakness (HP:0009027)3.00424371
43Overlapping toe (HP:0001845)2.94009800
44Annular pancreas (HP:0001734)2.93781117
45Abnormal autonomic nervous system physiology (HP:0012332)2.91679966
46Popliteal pterygium (HP:0009756)2.87052188
47Cutaneous finger syndactyly (HP:0010554)2.85523877
48Amblyopia (HP:0000646)2.85052596
49Supranuclear gaze palsy (HP:0000605)2.84187578
50Hypoventilation (HP:0002791)2.83293031
51Progressive cerebellar ataxia (HP:0002073)2.80501441
52Bilateral microphthalmos (HP:0007633)2.79844094
53Hammertoe (HP:0001765)2.79610645
54Potter facies (HP:0002009)2.77028658
55Facial shape deformation (HP:0011334)2.77028658
56Cholelithiasis (HP:0001081)2.73803346
57Vertebral arch anomaly (HP:0008438)2.73401299
58Steppage gait (HP:0003376)2.69240359
59Abnormality of the vocal cords (HP:0008777)2.68640468
60Chronic bronchitis (HP:0004469)2.64979843
61Abnormality of the foot musculature (HP:0001436)2.63941828
62Exotropia (HP:0000577)2.62067198
63Abnormality of calcium-phosphate metabolism (HP:0100530)2.59394902
64Hypoplasia of the brainstem (HP:0002365)2.59334134
65Aplasia/Hypoplasia of the brainstem (HP:0007362)2.59334134
66Asymmetry of the thorax (HP:0001555)2.59082233
67Thyroid carcinoma (HP:0002890)2.58493206
68J-shaped sella turcica (HP:0002680)2.51208913
69Abnormal gallbladder morphology (HP:0012437)2.50430276
70Decreased muscle mass (HP:0003199)2.49465363
71Supernumerary spleens (HP:0009799)2.48536865
72Ankle clonus (HP:0011448)2.47904058
73Focal seizures (HP:0007359)2.46572059
74Congenital glaucoma (HP:0001087)2.45282614
75Cerebral hemorrhage (HP:0001342)2.44745840
76Postural tremor (HP:0002174)2.42774154
77Abnormality of the 2nd finger (HP:0004100)2.40610924
78Bronchiectasis (HP:0002110)2.40537500
79Orthostatic hypotension (HP:0001278)2.40149642
80Morphological abnormality of the middle ear (HP:0008609)2.37323189
81Partial agenesis of the corpus callosum (HP:0001338)2.36688245
82Atonic seizures (HP:0010819)2.36644605
83Absent phalangeal crease (HP:0006109)2.32461560
84Torticollis (HP:0000473)2.32242492
85Neoplasm of the heart (HP:0100544)2.31950527
86Down-sloping shoulders (HP:0200021)2.30224221
87Cutaneous syndactyly (HP:0012725)2.27300803
88Infertility (HP:0000789)2.25699168
89Occipital encephalocele (HP:0002085)2.25691156
90Pendular nystagmus (HP:0012043)2.24422609
91Aqueductal stenosis (HP:0002410)2.23858933
92Renovascular hypertension (HP:0100817)2.23327926
93Abnormality of the corticospinal tract (HP:0002492)2.21121685
94Abnormality of magnesium homeostasis (HP:0004921)2.20193711
95Atelectasis (HP:0100750)2.18885666
96Limb dystonia (HP:0002451)2.17621118
97Bifid tongue (HP:0010297)2.16512235
98Nasal polyposis (HP:0100582)2.16015232
99Febrile seizures (HP:0002373)2.14477812
100Depressed nasal tip (HP:0000437)2.13116417
101Genital tract atresia (HP:0001827)2.12690314
102Distal sensory impairment (HP:0002936)2.09258639
103Absent eyebrow (HP:0002223)2.09178434
104Depression (HP:0000716)2.09171544
105Gastrointestinal atresia (HP:0002589)2.08964291
106Fetal akinesia sequence (HP:0001989)2.07507777
107Abnormal pancreas size (HP:0012094)2.07008522
108Arthropathy (HP:0003040)2.05152919
109Short 4th metacarpal (HP:0010044)2.04912960
110Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.04912960
111Mask-like facies (HP:0000298)2.01536243
112Sensory axonal neuropathy (HP:0003390)2.01534301
113Autoamputation (HP:0001218)2.00488340
114Absent eyelashes (HP:0000561)1.99096034
115Vaginal atresia (HP:0000148)1.97280496
116Onion bulb formation (HP:0003383)1.97059113
117Rapidly progressive (HP:0003678)1.95933658
118Hypomagnesemia (HP:0002917)1.95350868
119Reticulocytosis (HP:0001923)1.95336591
120Bell-shaped thorax (HP:0001591)1.94932450
121Hyporeflexia of lower limbs (HP:0002600)1.94880442
122Gait imbalance (HP:0002141)1.94453968
123Hyperparathyroidism (HP:0000843)1.94446657
124Hyperthyroidism (HP:0000836)1.94379218
125Urinary urgency (HP:0000012)1.92956941
126Self-mutilation (HP:0000742)1.92672495
127Bony spicule pigmentary retinopathy (HP:0007737)1.92293089
128Male infertility (HP:0003251)1.91780325
129Renal hypoplasia (HP:0000089)1.91235970
130Abnormality of the lacrimal duct (HP:0011481)1.90647635
131Neuroblastic tumors (HP:0004376)1.89723454
132Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.89723454
133Neuroblastoma (HP:0003006)1.89723454
134Primitive neuroectodermal tumor (HP:0030065)1.89723454
135Agitation (HP:0000713)1.89005001
136Abnormality of the parathyroid morphology (HP:0011766)1.88472176
137High anterior hairline (HP:0009890)1.86522777
138Midline defect of the nose (HP:0004122)1.86143350
139Aplasia/Hypoplasia of the spleen (HP:0010451)1.85292059
140Abnormal finger flexion creases (HP:0006143)1.85024949
141Cortical dysplasia (HP:0002539)1.83813052
142Vitreoretinal degeneration (HP:0000655)1.83700606
143Renal dysplasia (HP:0000110)1.82776909
144Neonatal onset (HP:0003623)1.81410816
145Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.81341679
146Nephronophthisis (HP:0000090)1.78250156
147Congenital malformation of the right heart (HP:0011723)1.78207159
148Double outlet right ventricle (HP:0001719)1.78207159
149Chronic hepatic failure (HP:0100626)1.78052750
150Urinary bladder sphincter dysfunction (HP:0002839)1.78003882
151Wide intermamillary distance (HP:0006610)1.77832491
152Carpal bone hypoplasia (HP:0001498)1.77197422
153Insomnia (HP:0100785)1.76274826
154Abnormality of the lower motor neuron (HP:0002366)1.76205725
155Turricephaly (HP:0000262)1.75410342
156Tubulointerstitial nephritis (HP:0001970)1.75101933
157Hyperacusis (HP:0010780)1.70224381
158Esotropia (HP:0000565)1.63596508
159Abnormality of the ischium (HP:0003174)1.61655756
160Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.59689484
161Abnormality of the 4th metacarpal (HP:0010012)1.58450500
162Obsessive-compulsive behavior (HP:0000722)1.54881685
163Short palpebral fissure (HP:0012745)1.53323185
164Adducted thumb (HP:0001181)1.52914203
165Craniofacial dystonia (HP:0012179)1.51703643
166Anencephaly (HP:0002323)1.50552613
167Impaired vibration sensation in the lower limbs (HP:0002166)1.50486837
168Abnormality of the intervertebral disk (HP:0005108)1.49239159
169Hemorrhage of the eye (HP:0011885)1.49181041
170Abnormality of the nasal mucosa (HP:0000433)1.48943698
171Calcaneovalgus deformity (HP:0001848)1.47218121
172Recurrent corneal erosions (HP:0000495)1.46368272
173Abnormality of the phalanges of the hallux (HP:0010057)1.46234725

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK15.25756682
2KSR23.96625629
3LIMK13.79374759
4MAP3K23.48202586
5MAPK153.20942969
6GRK53.03179486
7LMTK22.96324610
8MINK12.92271668
9RET2.87518324
10MAP3K92.67336428
11NTRK32.67285244
12ICK2.46912123
13PTK2B2.33356180
14NTRK22.25807836
15LATS22.25799287
16MATK2.25041737
17BLK2.18004600
18TESK11.96036407
19TESK21.94626400
20INSRR1.88445190
21PLK41.83985983
22MAPKAPK31.74798659
23TLK11.73283087
24MAP3K121.63345779
25EPHA31.62159493
26ARAF1.60018240
27EEF2K1.58189446
28PHKG11.48514946
29PHKG21.48514946
30MAP2K11.46754971
31BCR1.37741791
32MAP3K11.36444306
33TRIB31.33612703
34MAP2K21.27960449
35DDR21.27812443
36DYRK1B1.25189158
37RIPK41.24570437
38PKN11.23366142
39RPS6KA21.22840379
40PAK61.22342998
41MAP3K41.22066896
42FGFR21.20631431
43MAP2K41.17567167
44MAP3K101.17430791
45CAMK1G1.16561670
46MARK11.15973157
47DAPK21.14229981
48MARK21.14198330
49FER1.11328498
50MAPK131.10552674
51STK391.09648230
52WNK11.01907496
53UHMK11.00402906
54AKT30.98471622
55MAP2K70.97859258
56BRD40.97389146
57PTK20.96902738
58RIPK10.93534760
59NEK10.92841941
60BMPR1B0.92388070
61CSNK1G10.91019420
62ADRBK10.90443475
63MTOR0.90402946
64PINK10.88739744
65WNK40.84434924
66DYRK1A0.84161935
67CDK50.81794195
68CDK140.80270160
69MAPKAPK50.79489248
70SGK4940.78726261
71SGK2230.78726261
72CAMKK20.77656787
73CSNK1A1L0.76506796
74ILK0.74723888
75MARK30.73407259
76SCYL20.69063527
77CDK80.66027340
78DYRK30.65735988
79CSNK1E0.65609651
80TAOK10.65388420
81PRKD30.62282348
82CAMKK10.62242518
83FLT30.61246576
84MKNK20.61176025
85NME20.60469227
86TRIM280.59534397
87EPHB20.59511546
88KSR10.58429808
89MAP3K60.57714148
90MAP3K110.54693646
91ADRBK20.54133556
92CAMK2D0.54034960
93PDGFRA0.54010628
94GRK70.53910923
95DYRK20.52605945
96PRKAA10.52222584
97PRKCG0.51340020
98PRKCH0.50842923
99FGFR30.50349070
100SGK20.50016893
101ZAP700.49211789
102CSNK1G30.48324466
103CDK180.47785479
104ERBB30.47780555
105DAPK10.47647041
106PRKCE0.47128960
107CSNK1G20.45967065
108MAPK90.45352816
109STK38L0.44981334
110DAPK30.44927327
111PRKG20.44657186
112CDK150.44524484
113TSSK60.43290793
114TYRO30.42378423
115TNK20.41888850
116STK240.41670581
117CDK120.41621483
118CDK30.40991109
119LATS10.39115733
120EPHB10.38249060
121CDK11A0.37508587
122CAMK2A0.37068414
123GSK3B0.36672071
124PIM20.36273796
125HIPK20.36207573
126CDC42BPA0.36130306
127ROCK20.35887532
128MAPK80.35713646
129SRC0.35453574
130PKN20.35181882
131ROCK10.35084518
132PBK0.34762187
133MAP3K70.34656657
134PAK30.34584492
135ZAK0.34398670
136STK110.34339997
137SRPK10.34114722
138SGK30.32918772
139PLK20.32914617
140RPS6KB10.32610743
141PNCK0.32467675
142CASK0.31820087
143LRRK20.31774696
144ERBB20.31762843
145PRKACA0.29575679
146AURKA0.28082432
147FGFR40.25059117
148PRKCZ0.24483012
149MET0.23337553
150NME10.23229951
151CAMK2G0.22836655
152CAMK40.21860428

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005246.92286625
2Synaptic vesicle cycle_Homo sapiens_hsa047213.10945796
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049613.07853376
4Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.77684919
5Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.38714992
6Hedgehog signaling pathway_Homo sapiens_hsa043402.35085898
7Alcoholism_Homo sapiens_hsa050342.26006146
8Thyroid cancer_Homo sapiens_hsa052162.02976064
9Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.99236819
10Carbohydrate digestion and absorption_Homo sapiens_hsa049731.89496833
11Central carbon metabolism in cancer_Homo sapiens_hsa052301.86204755
12Taste transduction_Homo sapiens_hsa047421.84692723
13Oxidative phosphorylation_Homo sapiens_hsa001901.74878679
14Parkinsons disease_Homo sapiens_hsa050121.73987660
15Cardiac muscle contraction_Homo sapiens_hsa042601.64390432
16Collecting duct acid secretion_Homo sapiens_hsa049661.61692221
17Basal cell carcinoma_Homo sapiens_hsa052171.61042820
18Insulin secretion_Homo sapiens_hsa049111.58661184
19Type II diabetes mellitus_Homo sapiens_hsa049301.50386506
20Cholinergic synapse_Homo sapiens_hsa047251.49576033
21Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.48932555
22Dorso-ventral axis formation_Homo sapiens_hsa043201.47836531
23Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.47762384
24Fructose and mannose metabolism_Homo sapiens_hsa000511.39996590
25Notch signaling pathway_Homo sapiens_hsa043301.39176123
26Hippo signaling pathway_Homo sapiens_hsa043901.36778510
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.36752349
28Olfactory transduction_Homo sapiens_hsa047401.32148115
29Dopaminergic synapse_Homo sapiens_hsa047281.31449762
30Alzheimers disease_Homo sapiens_hsa050101.29464659
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.27648530
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.27192493
33* Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.25256045
34Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.22299342
35Salivary secretion_Homo sapiens_hsa049701.21151214
36Tight junction_Homo sapiens_hsa045301.19374313
37Galactose metabolism_Homo sapiens_hsa000521.18485891
38Wnt signaling pathway_Homo sapiens_hsa043101.16356014
39Insulin signaling pathway_Homo sapiens_hsa049101.15640241
40Neurotrophin signaling pathway_Homo sapiens_hsa047221.15472427
41Long-term potentiation_Homo sapiens_hsa047201.14608909
42Steroid biosynthesis_Homo sapiens_hsa001001.09308022
43Long-term depression_Homo sapiens_hsa047301.07979951
44Colorectal cancer_Homo sapiens_hsa052101.07278759
45Circadian entrainment_Homo sapiens_hsa047131.06163158
46Thyroid hormone signaling pathway_Homo sapiens_hsa049191.02876330
47Glioma_Homo sapiens_hsa052141.02260801
48Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.01185096
49Gap junction_Homo sapiens_hsa045401.00111465
50GnRH signaling pathway_Homo sapiens_hsa049120.99588314
51Serotonergic synapse_Homo sapiens_hsa047260.97706870
52Vibrio cholerae infection_Homo sapiens_hsa051100.97609897
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.93342152
54Huntingtons disease_Homo sapiens_hsa050160.92536149
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.87970655
56Starch and sucrose metabolism_Homo sapiens_hsa005000.87181977
57Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87135136
58Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86643715
59Estrogen signaling pathway_Homo sapiens_hsa049150.86414041
60Bile secretion_Homo sapiens_hsa049760.85714052
61Glutamatergic synapse_Homo sapiens_hsa047240.84715614
62VEGF signaling pathway_Homo sapiens_hsa043700.83720290
63Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.80884437
64Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.79792198
65Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.79132159
66Gastric acid secretion_Homo sapiens_hsa049710.78918979
67Longevity regulating pathway - mammal_Homo sapiens_hsa042110.77205609
68Fatty acid biosynthesis_Homo sapiens_hsa000610.75452266
69Endometrial cancer_Homo sapiens_hsa052130.75407551
70Systemic lupus erythematosus_Homo sapiens_hsa053220.75179634
71Dilated cardiomyopathy_Homo sapiens_hsa054140.74834078
72Oocyte meiosis_Homo sapiens_hsa041140.74176534
73Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.73007445
74Chronic myeloid leukemia_Homo sapiens_hsa052200.72078159
75Melanoma_Homo sapiens_hsa052180.71662707
76Endocytosis_Homo sapiens_hsa041440.70975456
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.70919753
78Amphetamine addiction_Homo sapiens_hsa050310.70278850
79Prolactin signaling pathway_Homo sapiens_hsa049170.69051224
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68516394
81Pancreatic secretion_Homo sapiens_hsa049720.66989816
82AMPK signaling pathway_Homo sapiens_hsa041520.66913137
83Phagosome_Homo sapiens_hsa041450.66698784
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65979273
85Arginine biosynthesis_Homo sapiens_hsa002200.63262145
86Thyroid hormone synthesis_Homo sapiens_hsa049180.63115849
87Aldosterone synthesis and secretion_Homo sapiens_hsa049250.61465277
88Salmonella infection_Homo sapiens_hsa051320.61119921
89Melanogenesis_Homo sapiens_hsa049160.60207380
90Renin secretion_Homo sapiens_hsa049240.59876716
91Butanoate metabolism_Homo sapiens_hsa006500.59357001
92Regulation of autophagy_Homo sapiens_hsa041400.59174044
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.58564888
94mRNA surveillance pathway_Homo sapiens_hsa030150.58311818
95Axon guidance_Homo sapiens_hsa043600.58270975
96Nicotine addiction_Homo sapiens_hsa050330.58261924
97Oxytocin signaling pathway_Homo sapiens_hsa049210.57469310
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56749913
99TGF-beta signaling pathway_Homo sapiens_hsa043500.56309132
100mTOR signaling pathway_Homo sapiens_hsa041500.55978595
101GABAergic synapse_Homo sapiens_hsa047270.55948969
102Mineral absorption_Homo sapiens_hsa049780.55871397
103Tyrosine metabolism_Homo sapiens_hsa003500.55822911
104Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54797253
105Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.54684154
106ErbB signaling pathway_Homo sapiens_hsa040120.54323713
107Adherens junction_Homo sapiens_hsa045200.53865059
108Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53606083
109Phototransduction_Homo sapiens_hsa047440.53411934
110Morphine addiction_Homo sapiens_hsa050320.52682802
111Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.52391752
112Protein digestion and absorption_Homo sapiens_hsa049740.52328174
113Prion diseases_Homo sapiens_hsa050200.51955364
114Inositol phosphate metabolism_Homo sapiens_hsa005620.51939604
115HIF-1 signaling pathway_Homo sapiens_hsa040660.51834307
116Phenylalanine metabolism_Homo sapiens_hsa003600.50243181
117Cocaine addiction_Homo sapiens_hsa050300.49557946
118Prostate cancer_Homo sapiens_hsa052150.48628124
119Vascular smooth muscle contraction_Homo sapiens_hsa042700.47919001
120Choline metabolism in cancer_Homo sapiens_hsa052310.47807992
121Calcium signaling pathway_Homo sapiens_hsa040200.47368693
122cGMP-PKG signaling pathway_Homo sapiens_hsa040220.43576848
123Rap1 signaling pathway_Homo sapiens_hsa040150.43013944
124Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.40713880
125Bladder cancer_Homo sapiens_hsa052190.40262876
126Non-small cell lung cancer_Homo sapiens_hsa052230.40055206
127cAMP signaling pathway_Homo sapiens_hsa040240.36682968
128Renin-angiotensin system_Homo sapiens_hsa046140.36386967
129Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.35500383
130Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.35434621
131Platelet activation_Homo sapiens_hsa046110.35053999
132Glycerophospholipid metabolism_Homo sapiens_hsa005640.33463146

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