PRPH2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein found in the outer segment of both rod and cone photoreceptor cells. It may function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. This protein is essential for disk morphogenesis. Defects in this gene are associated with both central and peripheral retinal degenerations. Some of the various phenotypically different disorders are autosomal dominant retinitis pigmentosa, progressive macular degeneration, macular dystrophy and retinitis pigmentosa digenic. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of guanylate cyclase activity (GO:0031284)9.49922210
2protein-chromophore linkage (GO:0018298)9.18749335
3* visual perception (GO:0007601)8.64019954
4regulation of guanylate cyclase activity (GO:0031282)8.58527567
5* sensory perception of light stimulus (GO:0050953)8.53937269
6cellular response to light stimulus (GO:0071482)7.65600650
7photoreceptor cell differentiation (GO:0046530)7.38000954
8eye photoreceptor cell differentiation (GO:0001754)7.38000954
9detection of external stimulus (GO:0009581)7.09545484
10detection of abiotic stimulus (GO:0009582)6.95419545
11regulation of cGMP metabolic process (GO:0030823)6.23858247
12* retina development in camera-type eye (GO:0060041)6.00638873
13positive regulation of cGMP biosynthetic process (GO:0030828)5.58614757
14regulation of inhibitory postsynaptic membrane potential (GO:0060080)5.32323793
15regulation of cGMP biosynthetic process (GO:0030826)5.24501778
16regulation of skeletal muscle contraction (GO:0014819)4.96240937
17cellular response to radiation (GO:0071478)4.93439418
18positive regulation of cGMP metabolic process (GO:0030825)4.92105021
19receptor guanylyl cyclase signaling pathway (GO:0007168)4.82724966
20nonmotile primary cilium assembly (GO:0035058)4.79904418
21adaptation of signaling pathway (GO:0023058)4.76746376
22cell morphogenesis involved in neuron differentiation (GO:0048667)4.71279696
23detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)4.51822362
24negative regulation of cytosolic calcium ion concentration (GO:0051481)4.48874451
25positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.45710786
26regulation of clathrin-mediated endocytosis (GO:2000369)4.44001713
27regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)4.37503044
28actin-myosin filament sliding (GO:0033275)4.35696880
29muscle filament sliding (GO:0030049)4.35696880
30regulation of voltage-gated calcium channel activity (GO:1901385)4.04154380
31* sensory perception (GO:0007600)4.03008921
32estrogen biosynthetic process (GO:0006703)4.00874748
33protein K11-linked deubiquitination (GO:0035871)3.98290623
34sarcoplasmic reticulum calcium ion transport (GO:0070296)3.96010995
35protein prenylation (GO:0018342)3.92226960
36prenylation (GO:0097354)3.92226960
37mesenchymal-epithelial cell signaling (GO:0060638)3.91643384
38response to light stimulus (GO:0009416)3.91187191
39retina layer formation (GO:0010842)3.87125232
40negative regulation of cAMP-mediated signaling (GO:0043951)3.81685310
41positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.73968970
42actin-mediated cell contraction (GO:0070252)3.68332989
43negative regulation of receptor-mediated endocytosis (GO:0048261)3.66168902
44neuron development (GO:0048666)3.62932044
45positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.60387589
46skeletal muscle contraction (GO:0003009)3.57189653
47retina homeostasis (GO:0001895)3.55553590
48protein localization to synapse (GO:0035418)3.50555281
49regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.43662041
50regulation of short-term neuronal synaptic plasticity (GO:0048172)3.41726647
51regulation of cardioblast proliferation (GO:0003264)3.35877132
52regulation of secondary heart field cardioblast proliferation (GO:0003266)3.35877132
53CDP-diacylglycerol biosynthetic process (GO:0016024)3.32426830
54regulation of female receptivity (GO:0045924)3.30084228
55myofibril assembly (GO:0030239)3.25266450
56positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.21742814
57short-term memory (GO:0007614)3.19124556
58peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.18860926
59behavioral response to ethanol (GO:0048149)3.12911570
60otic vesicle formation (GO:0030916)3.08949864
61retinoid metabolic process (GO:0001523)3.07537021
62positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.07321043
63CDP-diacylglycerol metabolic process (GO:0046341)3.05236001
64regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.04619920
65regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.04619920
66membrane hyperpolarization (GO:0060081)3.03895478
67regulation of meiosis I (GO:0060631)3.01869820
68positive regulation of sodium ion transmembrane transport (GO:1902307)3.00195605
69chemosensory behavior (GO:0007635)2.99642157
70positive regulation of fatty acid oxidation (GO:0046321)2.99624215
71positive regulation of neurotransmitter transport (GO:0051590)2.99538739
72opioid receptor signaling pathway (GO:0038003)2.99087762
73inner ear receptor stereocilium organization (GO:0060122)2.97951950
74phospholipid translocation (GO:0045332)2.97125574
75lipid translocation (GO:0034204)2.97125574
76regulation of glucokinase activity (GO:0033131)2.95592159
77regulation of hexokinase activity (GO:1903299)2.95592159
78regulation of penile erection (GO:0060405)2.95206600
79membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.92677104
80regulation of energy homeostasis (GO:2000505)2.91122958
81protein localization to cell surface (GO:0034394)2.90365299
82response to histamine (GO:0034776)2.89070051
83synaptic vesicle maturation (GO:0016188)2.87113818
84nephron epithelium morphogenesis (GO:0072088)2.84850898
85nephron tubule morphogenesis (GO:0072078)2.84850898
86diterpenoid metabolic process (GO:0016101)2.84794994
87relaxation of cardiac muscle (GO:0055119)2.82076739
88regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.81304009
89kidney morphogenesis (GO:0060993)2.81079803
90regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.80292988
91relaxation of muscle (GO:0090075)2.78686503
92axoneme assembly (GO:0035082)2.77104900
93G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.76599366
94energy homeostasis (GO:0097009)2.76266939
95regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.75710320
96neuromuscular synaptic transmission (GO:0007274)2.72577268
97striated muscle contraction (GO:0006941)2.70376432
98synaptic vesicle docking involved in exocytosis (GO:0016081)2.68395514
99positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.67644306
100response to radiation (GO:0009314)2.67621681
101retinol metabolic process (GO:0042572)2.67188534
102pancreas development (GO:0031016)2.65621318
103lipoprotein transport (GO:0042953)2.65607002
104response to pheromone (GO:0019236)2.64879151
105nephron tubule formation (GO:0072079)2.64469493
106cellular ketone body metabolic process (GO:0046950)2.63318408
107female mating behavior (GO:0060180)2.62573044
108skeletal muscle fiber development (GO:0048741)2.61870965
109innervation (GO:0060384)2.61368563
110terpenoid metabolic process (GO:0006721)2.60910215
111negative regulation of transcription regulatory region DNA binding (GO:2000678)2.60262887
112post-embryonic morphogenesis (GO:0009886)2.60248053
113icosanoid secretion (GO:0032309)2.59619863
114arachidonic acid secretion (GO:0050482)2.59619863
115plasma membrane repair (GO:0001778)2.58698447
116negative regulation of cation channel activity (GO:2001258)2.56552040
117auditory receptor cell stereocilium organization (GO:0060088)2.53929912
118actin filament-based movement (GO:0030048)2.52915471
119negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.52503136
120negative regulation of calcium ion transmembrane transport (GO:1903170)2.52503136
121inositol phosphate catabolic process (GO:0071545)2.52116804
122dopamine receptor signaling pathway (GO:0007212)2.52036410
123detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.51520259
124meiotic chromosome segregation (GO:0045132)2.51140636
125membrane depolarization during action potential (GO:0086010)2.50290585
126cellular potassium ion homeostasis (GO:0030007)2.49327671
127cellular response to abiotic stimulus (GO:0071214)2.49292768
128musculoskeletal movement (GO:0050881)2.48872696
129multicellular organismal movement (GO:0050879)2.48872696
130neuron maturation (GO:0042551)2.48450701
131dopamine transport (GO:0015872)2.46404187
132positive regulation of fatty acid beta-oxidation (GO:0032000)2.46367876
133positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)2.46218217
134keratan sulfate catabolic process (GO:0042340)2.45602582
135positive regulation of receptor internalization (GO:0002092)2.44801667
136renal tubule morphogenesis (GO:0061333)2.44082204
137mitochondrion transport along microtubule (GO:0047497)2.43882502
138establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.43882502
139endocardial cushion morphogenesis (GO:0003203)2.43334973
140positive regulation of triglyceride biosynthetic process (GO:0010867)2.42626780
141muscle cell fate commitment (GO:0042693)2.42426800
142negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.41801663
143dentate gyrus development (GO:0021542)2.41239082
144regulation of fatty acid oxidation (GO:0046320)2.40474192
145ketone body metabolic process (GO:1902224)2.38917564
146muscle contraction (GO:0006936)2.38712967
147protein heterotetramerization (GO:0051290)2.37872871
148regulation of cell communication by electrical coupling (GO:0010649)2.37352348
149coenzyme catabolic process (GO:0009109)2.37018251
150behavioral response to nicotine (GO:0035095)2.36657632
151detection of chemical stimulus involved in sensory perception (GO:0050907)2.36368619
152sodium ion export (GO:0071436)2.35959968
153spinal cord motor neuron differentiation (GO:0021522)2.35917882
154positive regulation of meiosis (GO:0045836)2.35128456
155cellular response to hepatocyte growth factor stimulus (GO:0035729)2.33889703
156response to hepatocyte growth factor (GO:0035728)2.33889703
157cellular response to electrical stimulus (GO:0071257)2.33444423
158skeletal muscle tissue development (GO:0007519)2.33252780
159positive regulation of cyclase activity (GO:0031281)2.33046180
160behavioral response to cocaine (GO:0048148)2.32681736
161myotube cell development (GO:0014904)2.32184778
162regulation of triglyceride biosynthetic process (GO:0010866)2.31012051
163positive regulation of gluconeogenesis (GO:0045722)2.30799229
164phosphate ion homeostasis (GO:0055062)2.30537267
165trivalent inorganic anion homeostasis (GO:0072506)2.30537267
166cardiac myofibril assembly (GO:0055003)2.30498086
167response to muscle activity (GO:0014850)2.28722270
168regulation of protein glycosylation (GO:0060049)2.28415202
169regulation of relaxation of muscle (GO:1901077)2.28070752
170regulation of rhodopsin mediated signaling pathway (GO:0022400)18.5236148
171rhodopsin mediated signaling pathway (GO:0016056)18.1087588
172retinal cone cell development (GO:0046549)14.4670812
173photoreceptor cell development (GO:0042461)12.3217456
174photoreceptor cell maintenance (GO:0045494)12.1410797
175eye photoreceptor cell development (GO:0042462)11.6660256
176detection of light stimulus involved in visual perception (GO:0050908)11.0774158
177detection of light stimulus involved in sensory perception (GO:0050962)11.0774158
178phototransduction (GO:0007602)10.7151867
179phototransduction, visible light (GO:0007603)10.6472705
180GMP metabolic process (GO:0046037)10.4538262
181detection of light stimulus (GO:0009583)10.1653920
182detection of visible light (GO:0009584)10.1368068
183retinal rod cell development (GO:0046548)10.0940884

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse4.52809242
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.36275766
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.48451049
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.27277965
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.84980105
6CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.58839930
7VDR_22108803_ChIP-Seq_LS180_Human2.58798515
8DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.53412666
9CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.49601504
10GBX2_23144817_ChIP-Seq_PC3_Human2.39608621
11DROSHA_22980978_ChIP-Seq_HELA_Human2.34105967
12EZH2_22144423_ChIP-Seq_EOC_Human2.13473363
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.13140117
14BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human2.03118709
15TAF15_26573619_Chip-Seq_HEK293_Human1.97289629
16FUS_26573619_Chip-Seq_HEK293_Human1.90629150
17SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.89308336
18PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.87180807
19SMAD3_21741376_ChIP-Seq_HESCs_Human1.84621695
20PIAS1_25552417_ChIP-Seq_VCAP_Human1.82082287
21KDM2B_26808549_Chip-Seq_K562_Human1.81082852
22SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.81002806
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.80868186
24POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.72443223
25TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72443223
26AR_21572438_ChIP-Seq_LNCaP_Human1.72433078
27REST_18959480_ChIP-ChIP_MESCs_Mouse1.71595061
28RARB_27405468_Chip-Seq_BRAIN_Mouse1.71439161
29SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.65720981
30SUZ12_27294783_Chip-Seq_ESCs_Mouse1.64723485
31EZH2_27294783_Chip-Seq_ESCs_Mouse1.63872082
32REST_21632747_ChIP-Seq_MESCs_Mouse1.61159660
33TCF4_18268006_ChIP-ChIP_LS174T_Human1.60250155
34AR_19668381_ChIP-Seq_PC3_Human1.59162713
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.57561311
36MTF2_20144788_ChIP-Seq_MESCs_Mouse1.54274347
37IKZF1_21737484_ChIP-ChIP_HCT116_Human1.53557349
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.51112232
39EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50481780
40P53_22127205_ChIP-Seq_FIBROBLAST_Human1.47101264
41SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45684248
42AR_25329375_ChIP-Seq_VCAP_Human1.45317665
43RING1B_27294783_Chip-Seq_NPCs_Mouse1.45009018
44GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.44359666
45MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.42743121
46TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.42006599
47SMC4_20622854_ChIP-Seq_HELA_Human1.41425419
48IGF1R_20145208_ChIP-Seq_DFB_Human1.41180423
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40904441
50POU3F2_20337985_ChIP-ChIP_501MEL_Human1.38602878
51ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.37850149
52EP300_21415370_ChIP-Seq_HL-1_Mouse1.37169819
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.37092521
54EZH2_27294783_Chip-Seq_NPCs_Mouse1.36775371
55CTCF_27219007_Chip-Seq_Bcells_Human1.35837098
56RBPJ_22232070_ChIP-Seq_NCS_Mouse1.34805425
57EWS_26573619_Chip-Seq_HEK293_Human1.34356299
58SMAD3_21741376_ChIP-Seq_EPCs_Human1.33210793
59SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.33135605
60RNF2_18974828_ChIP-Seq_MESCs_Mouse1.32766103
61EZH2_18974828_ChIP-Seq_MESCs_Mouse1.32766103
62SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31742160
63NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.30669217
64TBL1_22424771_ChIP-Seq_293T_Human1.29869789
65ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.29034277
66PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28648904
67CBP_20019798_ChIP-Seq_JUKART_Human1.28523856
68IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28523856
69SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.28086179
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27189601
71SMAD4_21799915_ChIP-Seq_A2780_Human1.27102248
72SALL1_21062744_ChIP-ChIP_HESCs_Human1.25965384
73CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25117362
74NFE2_27457419_Chip-Seq_LIVER_Mouse1.24900454
75OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24787321
76TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24263644
77JARID2_20075857_ChIP-Seq_MESCs_Mouse1.23125382
78KDM2B_26808549_Chip-Seq_JURKAT_Human1.22494225
79NANOG_18555785_Chip-Seq_ESCs_Mouse1.21719340
80TRIM28_21343339_ChIP-Seq_HEK293_Human1.21407198
81ER_23166858_ChIP-Seq_MCF-7_Human1.20646390
82ESR1_20079471_ChIP-ChIP_T-47D_Human1.20556769
83CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.20548752
84SMAD4_21741376_ChIP-Seq_EPCs_Human1.20044634
85CJUN_26792858_Chip-Seq_BT549_Human1.19988569
86SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.19357650
87ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.19215088
88TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.18959441
89FLI1_21867929_ChIP-Seq_TH2_Mouse1.18751197
90EGR1_23403033_ChIP-Seq_LIVER_Mouse1.18734998
91RNF2_27304074_Chip-Seq_ESCs_Mouse1.18637210
92PCGF2_27294783_Chip-Seq_NPCs_Mouse1.17785669
93CRX_20693478_ChIP-Seq_RETINA_Mouse1.17138814
94EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.17020609
95EGR1_19032775_ChIP-ChIP_M12_Human1.16093641
96BCAT_22108803_ChIP-Seq_LS180_Human1.16053224
97TAF2_19829295_ChIP-Seq_ESCs_Human1.15915365
98EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15684731
99ELK4_26923725_Chip-Seq_MESODERM_Mouse1.15098281
100MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.14818049
101NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14714113
102CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14583428
103TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.14371012
104LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13684137
105ZNF217_24962896_ChIP-Seq_MCF-7_Human1.13177802
106CDX2_22108803_ChIP-Seq_LS180_Human1.12422081
107NR3C1_23031785_ChIP-Seq_PC12_Mouse1.12068155
108P68_20966046_ChIP-Seq_HELA_Human1.12057709
109* CREB1_26743006_Chip-Seq_LNCaP_Human1.12050020
110STAT3_23295773_ChIP-Seq_U87_Human1.11863358
111SOX2_19829295_ChIP-Seq_ESCs_Human1.11644620
112NANOG_19829295_ChIP-Seq_ESCs_Human1.11644620
113FOXM1_26456572_ChIP-Seq_MCF-7_Human1.11325266
114HTT_18923047_ChIP-ChIP_STHdh_Human1.11285927
115WDR5_24793694_ChIP-Seq_LNCAP_Human1.10308375
116ISL1_27105846_Chip-Seq_CPCs_Mouse1.10063091
117DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.09597260
118OCT4_21477851_ChIP-Seq_ESCs_Mouse1.09475488
119CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.09382216
120* KDM2B_26808549_Chip-Seq_REH_Human1.08887104
121CTCF_20526341_ChIP-Seq_ESCs_Human1.08877299
122ERG_21242973_ChIP-ChIP_JURKAT_Human1.08873691
123SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08583521
124SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.08279585
125NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.07545919
126NRF2_20460467_ChIP-Seq_MEFs_Mouse1.07545919
127PRDM14_20953172_ChIP-Seq_ESCs_Human1.07227581
128ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06980828
129NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.06043991
130TP53_22573176_ChIP-Seq_HFKS_Human1.05536532
131TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05394928
132EZH2_27304074_Chip-Seq_ESCs_Mouse1.05265138
133LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03605089
134BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03122490
135OCT1_27270436_Chip-Seq_PROSTATE_Human1.02896005
136SMAD_19615063_ChIP-ChIP_OVARY_Human1.02729841
137P53_22387025_ChIP-Seq_ESCs_Mouse1.02402255
138SMAD4_21741376_ChIP-Seq_ESCs_Human1.01666704
139CBP_21632823_ChIP-Seq_H3396_Human1.01041094
140NCOR_22424771_ChIP-Seq_293T_Human1.00833848
141SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.99318547
142RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.96706550
143GATA1_19941827_ChIP-Seq_MEL_Mouse0.96389667
144OCT4_19829295_ChIP-Seq_ESCs_Human0.96323710
145SA1_27219007_Chip-Seq_Bcells_Human0.95712272
146YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95702957
147* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95301797
148SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.92504900
149EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.92390876
150MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91783065
151EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.91735966
152CDX2_19796622_ChIP-Seq_MESCs_Mouse0.90840295
153AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90229647
154* SMAD4_21741376_ChIP-Seq_HESCs_Human0.89599964
155P300_19829295_ChIP-Seq_ESCs_Human0.87739452
156GF1_26923725_Chip-Seq_HPCs_Mouse0.87721653
157FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.87600917
158RING1B_27294783_Chip-Seq_ESCs_Mouse0.87175020
159* DPY_21335234_ChIP-Seq_ESCs_Mouse0.86976136
160WT1_25993318_ChIP-Seq_PODOCYTE_Human0.86049557
161TCF4_23295773_ChIP-Seq_U87_Human0.85041749
162RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.84622249
163VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.84606982
164CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.84208404
165P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.82851096
166SMAD3_21741376_ChIP-Seq_ESCs_Human0.82469783
167TP53_23651856_ChIP-Seq_MEFs_Mouse0.81992510
168JARID2_20064375_ChIP-Seq_MESCs_Mouse0.81835963

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0005551_abnormal_eye_electrophysiolog9.71796302
2* MP0005253_abnormal_eye_physiology6.70117034
3* MP0006072_abnormal_retinal_apoptosis5.49698997
4MP0003950_abnormal_plasma_membrane4.22562357
5* MP0005195_abnormal_posterior_eye3.89545980
6* MP0005391_vision/eye_phenotype3.24846087
7* MP0001324_abnormal_eye_pigmentation3.22988961
8MP0005503_abnormal_tendon_morphology3.15628423
9MP0002638_abnormal_pupillary_reflex3.03713273
10MP0002090_abnormal_vision3.01713818
11MP0005423_abnormal_somatic_nervous2.71049412
12MP0002229_neurodegeneration2.68450793
13MP0003195_calcinosis2.41400798
14MP0000013_abnormal_adipose_tissue2.38733502
15MP0001764_abnormal_homeostasis2.19991772
16MP0000749_muscle_degeneration2.18350825
17MP0001986_abnormal_taste_sensitivity2.00078290
18MP0003011_delayed_dark_adaptation11.5777776
19MP0005275_abnormal_skin_tensile1.94362075
20* MP0002752_abnormal_somatic_nervous1.90427458
21MP0002837_dystrophic_cardiac_calcinosis1.89916268
22MP0002876_abnormal_thyroid_physiology1.84974708
23MP0000372_irregular_coat_pigmentation1.79819087
24MP0002653_abnormal_ependyma_morphology1.62523351
25MP0005369_muscle_phenotype1.60664396
26MP0005220_abnormal_exocrine_pancreas1.59640398
27MP0002138_abnormal_hepatobiliary_system1.58087693
28MP0010234_abnormal_vibrissa_follicle1.57356697
29MP0002106_abnormal_muscle_physiology1.53588815
30MP0002163_abnormal_gland_morphology1.51037667
31MP0003879_abnormal_hair_cell1.49292740
32MP0004130_abnormal_muscle_cell1.48212417
33MP0004484_altered_response_of1.47993550
34MP0004019_abnormal_vitamin_homeostasis1.42452795
35* MP0002882_abnormal_neuron_morphology1.39157551
36MP0008877_abnormal_DNA_methylation1.37394908
37MP0002139_abnormal_hepatobiliary_system1.29955026
38MP0005379_endocrine/exocrine_gland_phen1.27426019
39MP0001664_abnormal_digestion1.25508056
40MP0001756_abnormal_urination1.23750831
41MP0004233_abnormal_muscle_weight1.22519592
42MP0001502_abnormal_circadian_rhythm1.21636880
43MP0001944_abnormal_pancreas_morphology1.20699747
44MP0000747_muscle_weakness1.17264320
45MP0004087_abnormal_muscle_fiber1.17080626
46MP0000759_abnormal_skeletal_muscle1.15727255
47MP0003122_maternal_imprinting1.15663559
48MP0004885_abnormal_endolymph1.11512844
49MP0002269_muscular_atrophy1.07297146
50MP0000003_abnormal_adipose_tissue1.07026566
51MP0004084_abnormal_cardiac_muscle1.05278978
52MP0005197_abnormal_uvea_morphology1.04084194
53MP0003136_yellow_coat_color1.03833556
54MP0006036_abnormal_mitochondrial_physio1.03675961
55MP0005646_abnormal_pituitary_gland1.03000993
56MP0002132_abnormal_respiratory_system1.02973446
57MP0001984_abnormal_olfaction1.02803629
58MP0005174_abnormal_tail_pigmentation1.00430176
59MP0000230_abnormal_systemic_arterial0.96640128
60MP0004270_analgesia0.95330890
61MP0002896_abnormal_bone_mineralization0.93706393
62MP0005645_abnormal_hypothalamus_physiol0.93280005
63MP0001501_abnormal_sleep_pattern0.92017868
64MP0002972_abnormal_cardiac_muscle0.91779291
65MP0005084_abnormal_gallbladder_morpholo0.91138922
66MP0002693_abnormal_pancreas_physiology0.89495944
67MP0005394_taste/olfaction_phenotype0.87351137
68MP0005499_abnormal_olfactory_system0.87351137
69MP0002078_abnormal_glucose_homeostasis0.86966306
70MP0005187_abnormal_penis_morphology0.83846387
71MP0002127_abnormal_cardiovascular_syste0.83667078
72MP0002332_abnormal_exercise_endurance0.83247574
73MP0006292_abnormal_olfactory_placode0.83239137
74MP0001486_abnormal_startle_reflex0.81215341
75MP0005377_hearing/vestibular/ear_phenot0.81210801
76MP0003878_abnormal_ear_physiology0.81210801
77MP0005332_abnormal_amino_acid0.80348902
78MP0006276_abnormal_autonomic_nervous0.78865564
79MP0002295_abnormal_pulmonary_circulatio0.77213818
80MP0008775_abnormal_heart_ventricle0.76331316
81MP0008438_abnormal_cutaneous_collagen0.74901472
82MP0009250_abnormal_appendicular_skeleto0.74695545
83MP0008872_abnormal_physiological_respon0.74417290
84MP0001544_abnormal_cardiovascular_syste0.74064870
85MP0005385_cardiovascular_system_phenoty0.74064870
86MP0002272_abnormal_nervous_system0.73611447
87MP0000750_abnormal_muscle_regeneration0.72599380
88MP0008789_abnormal_olfactory_epithelium0.71315508
89MP0003880_abnormal_central_pattern0.68579382
90* MP0003634_abnormal_glial_cell0.66228149
91MP0004859_abnormal_synaptic_plasticity0.60656172
92MP0002064_seizures0.56447257
93MP0002734_abnormal_mechanical_nocicepti0.55352303
94MP0009046_muscle_twitch0.54028141
95MP0003635_abnormal_synaptic_transmissio0.52679925
96MP0005376_homeostasis/metabolism_phenot0.49486240
97MP0001963_abnormal_hearing_physiology0.49272475
98MP0000465_gastrointestinal_hemorrhage0.46501307
99MP0004215_abnormal_myocardial_fiber0.42326070
100MP0002063_abnormal_learning/memory/cond0.41204884
101MP0002067_abnormal_sensory_capabilities0.40484703
102MP0003045_fibrosis0.37001677
103MP0005248_abnormal_Harderian_gland0.35903390
104MP0002572_abnormal_emotion/affect_behav0.35630798
105MP0004924_abnormal_behavior0.34784692
106MP0005386_behavior/neurological_phenoty0.34784692
107MP0004145_abnormal_muscle_electrophysio0.33929308
108MP0009745_abnormal_behavioral_response0.32829492
109* MP0001286_abnormal_eye_development0.32552166
110MP0004085_abnormal_heartbeat0.31921965
111MP0004782_abnormal_surfactant_physiolog0.31672483
112MP0001968_abnormal_touch/_nociception0.31369351
113MP0002697_abnormal_eye_size0.31014232
114MP0005076_abnormal_cell_differentiation0.30212124
115MP0005620_abnormal_muscle_contractility0.29341950
116MP0009780_abnormal_chondrocyte_physiolo0.28789336
117MP0004043_abnormal_pH_regulation0.27308781
118MP0000631_abnormal_neuroendocrine_gland0.27176142
119MP0003890_abnormal_embryonic-extraembry0.27116499
120MP0001915_intracranial_hemorrhage0.26043095
121MP0005193_abnormal_anterior_eye0.25665425
122MP0000026_abnormal_inner_ear0.25446149
123MP0008569_lethality_at_weaning0.25255479
124MP0002152_abnormal_brain_morphology0.24127633
125MP0003252_abnormal_bile_duct0.23227558
126MP0005595_abnormal_vascular_smooth0.22894827
127MP0002066_abnormal_motor_capabilities/c0.22808470
128MP0004742_abnormal_vestibular_system0.22704136
129MP0004142_abnormal_muscle_tone0.22407920
130MP0008004_abnormal_stomach_pH0.22018035
131MP0004811_abnormal_neuron_physiology0.21995774
132MP0002928_abnormal_bile_duct0.21889096
133MP0002184_abnormal_innervation0.21749820
134MP0000751_myopathy0.20659727
135MP0001661_extended_life_span0.20603977
136MP0002102_abnormal_ear_morphology0.20503896
137MP0010386_abnormal_urinary_bladder0.19501470
138MP0003646_muscle_fatigue0.18990594
139MP0003632_abnormal_nervous_system0.18734279
140MP0003633_abnormal_nervous_system0.17371886
141MP0008961_abnormal_basal_metabolism0.17165821
142MP0002108_abnormal_muscle_morphology0.16910947
143MP0003943_abnormal_hepatobiliary_system0.15222577
144MP0000778_abnormal_nervous_system0.15197296
145MP0005330_cardiomyopathy0.15039219
146MP0010030_abnormal_orbit_morphology0.14528299
147MP0003631_nervous_system_phenotype0.13150787
148MP0002909_abnormal_adrenal_gland0.12519271
149MP0003638_abnormal_response/metabolism_0.11949597
150MP0001905_abnormal_dopamine_level0.10923765
151MP0003137_abnormal_impulse_conducting0.10140780
152MP0004036_abnormal_muscle_relaxation0.09866987
153MP0001177_atelectasis0.09803589
154MP0002557_abnormal_social/conspecific_i0.09384823
155MP0003956_abnormal_body_size0.08692055

Predicted human phenotypes

RankGene SetZ-score
1Chorioretinal atrophy (HP:0000533)9.30222289
2Central scotoma (HP:0000603)8.81186381
3Pendular nystagmus (HP:0012043)8.00176747
4Dyschromatopsia (HP:0007641)7.87285129
5Scotoma (HP:0000575)7.84348776
6Abnormality of macular pigmentation (HP:0008002)7.82901509
7Attenuation of retinal blood vessels (HP:0007843)7.77338385
8* Pigmentary retinal degeneration (HP:0001146)7.35618390
9Abolished electroretinogram (ERG) (HP:0000550)6.96990773
10Muscle fiber inclusion bodies (HP:0100299)6.48305451
11Decreased central vision (HP:0007663)6.32714220
12Nemaline bodies (HP:0003798)6.18180572
13Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)6.03570915
14* Type II diabetes mellitus (HP:0005978)5.65882429
15* Photophobia (HP:0000613)5.59212871
16Type 1 muscle fiber predominance (HP:0003803)5.43180533
17Macular degeneration (HP:0000608)5.18960934
18Increased corneal curvature (HP:0100692)5.17039097
19Keratoconus (HP:0000563)5.17039097
20Cone-rod dystrophy (HP:0000548)5.12842812
21Vitreoretinal degeneration (HP:0000655)5.07092094
22Posterior subcapsular cataract (HP:0007787)4.95346631
23Severe visual impairment (HP:0001141)4.77310704
24Constricted visual fields (HP:0001133)4.55907856
25Exercise-induced muscle cramps (HP:0003710)4.43608826
26Muscle hypertrophy of the lower extremities (HP:0008968)4.37055711
27* Retinitis pigmentosa (HP:0000510)4.25619613
28Calf muscle hypertrophy (HP:0008981)4.05895275
29Exercise-induced myalgia (HP:0003738)3.99665449
30Decreased electroretinogram (ERG) amplitude (HP:0000654)3.83524096
31Distal arthrogryposis (HP:0005684)3.66547405
32Rimmed vacuoles (HP:0003805)3.46117325
33Hypoplasia of the uterus (HP:0000013)3.41136977
34Progressive visual loss (HP:0000529)3.30772275
35Round ear (HP:0100830)3.19226570
36EMG: myopathic abnormalities (HP:0003458)3.16284267
37Retinal atrophy (HP:0001105)3.06628883
38Intestinal atresia (HP:0011100)3.05117097
39Subcapsular cataract (HP:0000523)3.02715728
40Metaphyseal dysplasia (HP:0100255)2.80399020
41Hyporeflexia of lower limbs (HP:0002600)2.67084959
42Abnormality of the calf musculature (HP:0001430)2.66554660
43Optic disc pallor (HP:0000543)2.61588819
44Hemiparesis (HP:0001269)2.61437554
45Aplasia/hypoplasia of the uterus (HP:0008684)2.60403340
46Hyperkalemia (HP:0002153)2.60088575
47Myoglobinuria (HP:0002913)2.58643970
48Hyperinsulinemic hypoglycemia (HP:0000825)2.52905087
49* Wide nasal bridge (HP:0000431)2.51361188
50Congenital sensorineural hearing impairment (HP:0008527)2.50657257
51Myopathic facies (HP:0002058)2.49603807
52Frequent falls (HP:0002359)2.47414809
53Wrist flexion contracture (HP:0001239)2.45141553
54Rhabdomyolysis (HP:0003201)2.38995379
55Gait imbalance (HP:0002141)2.38754807
56Congenital primary aphakia (HP:0007707)2.36652270
57Absent frontal sinuses (HP:0002688)2.33665047
58Arthropathy (HP:0003040)2.33211212
59Mesangial abnormality (HP:0001966)2.33094128
60* Choroideremia (HP:0001139)2.32964173
61Hypoplastic ischia (HP:0003175)2.29078192
62Absent phalangeal crease (HP:0006109)2.24872942
63Congenital malformation of the right heart (HP:0011723)2.22735900
64Double outlet right ventricle (HP:0001719)2.22735900
65Tubular atrophy (HP:0000092)2.18188702
66Ulnar deviation of the wrist (HP:0003049)2.17703680
67Muscle fiber splitting (HP:0003555)2.17676562
68Hamartoma of the eye (HP:0010568)2.13182809
69Hypomagnesemia (HP:0002917)2.12944526
70Ketoacidosis (HP:0001993)2.12302373
71Infantile muscular hypotonia (HP:0008947)2.10525427
72Nephrogenic diabetes insipidus (HP:0009806)2.08858047
73Calcaneovalgus deformity (HP:0001848)2.07052363
74Deformed tarsal bones (HP:0008119)2.04006873
75Late onset (HP:0003584)2.03808827
76Fetal akinesia sequence (HP:0001989)2.01009316
77Congenital stationary night blindness (HP:0007642)14.9199390
78Bony spicule pigmentary retinopathy (HP:0007737)12.2312534
79Absent rod-and cone-mediated responses on ERG (HP:0007688)10.6602406
80Abnormal rod and cone electroretinograms (HP:0008323)10.4232951
81Medial flaring of the eyebrow (HP:0010747)1.99091359
82Abnormality of the ischium (HP:0003174)1.93995415
83Persistence of primary teeth (HP:0006335)1.92416707
84Hyperglycemia (HP:0003074)1.88946631
85Abnormality of the vitreous humor (HP:0004327)1.87282826
86Sudden death (HP:0001699)1.86111779
87Slender build (HP:0001533)1.81894810
88Increased circulating renin level (HP:0000848)1.81719130
89Abnormality of aromatic amino acid family metabolism (HP:0004338)1.80579193
90Poor coordination (HP:0002370)1.80331395
91Interstitial pulmonary disease (HP:0006530)1.78859418
92Malignant hyperthermia (HP:0002047)1.78113009
93Focal seizures (HP:0007359)1.77728213
94Large for gestational age (HP:0001520)1.73427964
95Hip contracture (HP:0003273)1.72836889
96Thyroid-stimulating hormone excess (HP:0002925)1.71959050
97Dialeptic seizures (HP:0011146)1.71830656
98Abnormal drinking behavior (HP:0030082)1.71633389
99Polydipsia (HP:0001959)1.71633389
100Hyperphosphatemia (HP:0002905)1.71426652
101Abnormality of lateral ventricle (HP:0030047)1.71279058
102Action tremor (HP:0002345)1.71135387
103Abnormal pancreas size (HP:0012094)1.70727912
104Abnormal finger flexion creases (HP:0006143)1.67572902
105Polar cataract (HP:0010696)1.67438612
106Abnormality of potassium homeostasis (HP:0011042)1.65642311
107Delayed gross motor development (HP:0002194)1.64861304
108Testicular neoplasm (HP:0010788)1.64526180
109Abnormality of magnesium homeostasis (HP:0004921)1.64340257
110Asymmetric septal hypertrophy (HP:0001670)1.63780389
111Bundle branch block (HP:0011710)1.63521442
112Myotonia (HP:0002486)1.63451213
113Subacute progressive viral hepatitis (HP:0006572)1.63257935
114Subaortic stenosis (HP:0001682)1.63196831
115Abnormality of the left ventricular outflow tract (HP:0011103)1.63196831
116Vaginal atresia (HP:0000148)1.63039260
117Popliteal pterygium (HP:0009756)1.62895102
118* Optic atrophy (HP:0000648)1.61231266
119Genital tract atresia (HP:0001827)1.55808162
120Horizontal nystagmus (HP:0000666)1.53607994
121True hermaphroditism (HP:0010459)1.41459459
122Severe Myopia (HP:0011003)1.36211420
123Aplasia/Hypoplasia of the lens (HP:0008063)1.35360401
124Dysdiadochokinesis (HP:0002075)1.30982825
125Pancreatic fibrosis (HP:0100732)1.28238257
126Abnormality of the fovea (HP:0000493)1.23430759
127Epileptic encephalopathy (HP:0200134)1.18462692
128Aplasia/Hypoplasia of the fovea (HP:0008060)1.15872187
129Hypoplasia of the fovea (HP:0007750)1.15872187
130Astigmatism (HP:0000483)1.09528140
131Cystic liver disease (HP:0006706)1.08893205
132Recurrent sinusitis (HP:0011108)1.03356634
133Pancreatic cysts (HP:0001737)1.02144703
134Visual hallucinations (HP:0002367)0.99313045
135Febrile seizures (HP:0002373)0.97937954
136Specific learning disability (HP:0001328)0.97844106
137Left ventricular hypertrophy (HP:0001712)0.97262362
138Broad foot (HP:0001769)0.96579928
139Truncal ataxia (HP:0002078)0.95303540
140Cerebellar dysplasia (HP:0007033)0.94670672
141Aplasia/Hypoplasia of the tongue (HP:0010295)0.94028081
142Chorioretinal coloboma (HP:0000567)0.92867263
143Aplasia/Hypoplasia of the macula (HP:0008059)0.91397603
144Decreased testicular size (HP:0008734)0.91031127
145Progressive cerebellar ataxia (HP:0002073)0.89544406
146Asthma (HP:0002099)0.89366035
147Sclerocornea (HP:0000647)0.88414999
148Hypermetropia (HP:0000540)0.88343613
149Aplasia/Hypoplasia affecting the retina (HP:0008061)0.85141096
150Furrowed tongue (HP:0000221)0.78928480
151Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)0.78255029
152Prolonged QT interval (HP:0001657)0.73734627
153* Retinal detachment (HP:0000541)0.73158048
154Partial agenesis of the corpus callosum (HP:0001338)0.71199816
155Genetic anticipation (HP:0003743)0.70737867
156Abnormality of midbrain morphology (HP:0002418)0.70162711
157Molar tooth sign on MRI (HP:0002419)0.70162711
158Abnormality of dental color (HP:0011073)0.68350232
159Lymphopenia (HP:0001888)0.65625215
160Dental crowding (HP:0000678)0.65382225
161Hypodontia (HP:0000668)0.65228303
162Postaxial hand polydactyly (HP:0001162)0.63828167
163Short foot (HP:0001773)0.63569919
164Anencephaly (HP:0002323)0.63148624
165Chronic hepatic failure (HP:0100626)0.62469759
166Macroorchidism (HP:0000053)0.61394531
167Congenital hepatic fibrosis (HP:0002612)0.59645463
168Abnormality of the fingertips (HP:0001211)0.59359641
169Abnormality of cells of the lymphoid lineage (HP:0012140)0.59062551
170Generalized myoclonic seizures (HP:0002123)0.59002466
171Depression (HP:0000716)0.58965320
172Hypoventilation (HP:0002791)0.58620054
173Abnormal EKG (HP:0003115)0.58325189
174Abnormality of the lower motor neuron (HP:0002366)0.58007484
175Broad-based gait (HP:0002136)0.56710327
176Postural instability (HP:0002172)0.56590486

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK6.94348699
2OBSCN5.14476964
3PINK13.28786576
4IRAK22.67611482
5ADRBK22.43213607
6NLK2.32237420
7FGFR22.30644264
8GRK111.2427942
9PIK3CG1.97014791
10MAP3K101.88306409
11MST41.84699653
12TTN1.78692603
13BLK1.75004070
14SIK21.65880147
15FER1.65307612
16DAPK21.59286456
17CAMK1G1.49649106
18WNK31.48318180
19ADRBK11.45778212
20PAK61.42243799
21CDK121.36525903
22FGFR31.35472627
23MAPK71.34607902
24TAOK31.30327122
25LMTK21.29744273
26IRAK11.28376646
27MAPK121.28108269
28MAP4K21.27671366
29NEK11.25942846
30EPHB11.25816742
31BRD41.25620212
32CAMK1D1.23390536
33HIPK21.22033973
34INSRR1.20524215
35CSNK1G11.19458332
36MAP3K121.19167054
37SGK2231.18442475
38SGK4941.18442475
39STK381.18118527
40PKN21.16971769
41MUSK1.16087240
42ICK1.15450024
43MAP2K61.13471220
44TRPM71.13378378
45PRKD31.12587461
46MARK11.11210318
47RPS6KA41.08770512
48PNCK1.05822310
49MAP3K41.05745456
50CSNK1D1.04243280
51PRKCE1.03037607
52ERBB21.02074130
53PRKCH1.00236658
54FLT31.00221647
55TNIK1.00017486
56EPHA40.96996846
57PRKCZ0.96021079
58CAMKK20.88013424
59SGK20.87635379
60CAMKK10.87560200
61SGK30.82648689
62WNK10.78628423
63CSNK1G20.76967553
64CCNB10.76068712
65GSK3A0.73849770
66PRKAA10.73739869
67ROCK10.73437130
68AKT30.73375322
69PRKG20.72206822
70DYRK1A0.72116106
71PTK2B0.71863912
72PRKCB0.70347392
73GRK50.68304886
74CAMK2D0.65203281
75PRKACG0.62629626
76DYRK20.62545037
77NEK20.60117936
78MAP3K130.59596016
79PAK30.59560128
80MAPKAPK50.59485733
81MAPKAPK30.59212839
82TTK0.59184041
83DYRK1B0.59019917
84RPS6KA30.59015417
85PRKAA20.58037214
86MKNK20.57562532
87DYRK30.55239908
88CAMK2G0.55200463
89SCYL20.54764204
90CDK30.54666434
91FES0.54490715
92PLK20.53791693
93PHKG20.53090152
94PHKG10.53090152
95PRKD20.52973842
96PRKG10.52150250
97NUAK10.51914658
98MAP3K10.51856517
99BMPR1B0.51792367
100PDK10.51493306
101LATS10.48867669
102SGK10.48222425
103MAPK130.47699136
104CAMK10.47063071
105OXSR10.46627021
106CDK50.46431777
107PRKDC0.45973194
108GSK3B0.45020082
109MAP2K70.44419607
110SIK10.44329037
111MAPK90.42631422
112CDK90.42313671
113MAP3K70.42028065
114MAPK140.41811692
115STK30.41685597
116MINK10.41055293
117AKT20.40513922
118MAPK100.40097602
119NEK60.40046890
120CSNK1A10.38838974
121CSNK1G30.38224978
122CAMK40.37807396
123PLK30.37490139
124STK110.36667903
125CAMK2A0.35920513
126TIE10.35047306
127MYLK0.34620628
128MAP2K40.34142012
129CDK10.34108871
130PRKCG0.34011535
131ALK0.32879239
132EPHA30.31122643
133PRKACA0.30585292
134PKN10.29888033
135RPS6KB10.28878209
136FGFR40.27485156
137FRK0.27467722
138MAPK150.27079310
139PRKCA0.26632502
140STK390.26473379
141MAP2K10.26412905
142CSNK1E0.25115502
143CDC42BPA0.23442966
144NTRK30.22497589
145WNK40.22384009
146MAPK80.22369687
147PIK3CA0.22257673
148ATM0.20474551
149CHEK20.20370036
150PDK20.20255903
151PRKD10.18380650
152NTRK20.18230473
153CHEK10.18225727
154MAPK30.18145010
155MAP3K90.18063089

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.03524041
2Phototransduction_Homo sapiens_hsa0474415.8970636
3Propanoate metabolism_Homo sapiens_hsa006401.94263502
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.68305616
5Regulation of autophagy_Homo sapiens_hsa041401.67010037
6Synaptic vesicle cycle_Homo sapiens_hsa047211.66417150
7Arginine and proline metabolism_Homo sapiens_hsa003301.58542166
8Dorso-ventral axis formation_Homo sapiens_hsa043201.52011597
9Tryptophan metabolism_Homo sapiens_hsa003801.50464700
10Butanoate metabolism_Homo sapiens_hsa006501.48014995
11Folate biosynthesis_Homo sapiens_hsa007901.43319349
12Olfactory transduction_Homo sapiens_hsa047401.42966065
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.34230507
14Fatty acid degradation_Homo sapiens_hsa000711.33560334
15Long-term depression_Homo sapiens_hsa047301.27661651
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.26517853
17GABAergic synapse_Homo sapiens_hsa047271.24884974
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.21573296
19Oxidative phosphorylation_Homo sapiens_hsa001901.14274789
20Sulfur metabolism_Homo sapiens_hsa009201.05200708
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.02252500
22Retinol metabolism_Homo sapiens_hsa008300.93072957
23Cholinergic synapse_Homo sapiens_hsa047250.92919237
24Nitrogen metabolism_Homo sapiens_hsa009100.92774609
25Ether lipid metabolism_Homo sapiens_hsa005650.90681763
26Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.88283109
27Ovarian steroidogenesis_Homo sapiens_hsa049130.87833182
28Circadian rhythm_Homo sapiens_hsa047100.87773562
29Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.86530604
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.84996337
31Morphine addiction_Homo sapiens_hsa050320.83108350
32Circadian entrainment_Homo sapiens_hsa047130.82395826
33Alzheimers disease_Homo sapiens_hsa050100.80227709
34Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.79988259
35Selenocompound metabolism_Homo sapiens_hsa004500.79863520
36Glutamatergic synapse_Homo sapiens_hsa047240.79789101
37Dopaminergic synapse_Homo sapiens_hsa047280.76767594
38Fatty acid metabolism_Homo sapiens_hsa012120.73754483
39Glutathione metabolism_Homo sapiens_hsa004800.72327487
40FoxO signaling pathway_Homo sapiens_hsa040680.71674616
41Parkinsons disease_Homo sapiens_hsa050120.70508386
42Melanoma_Homo sapiens_hsa052180.69461402
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.67634312
44Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.66867392
45ABC transporters_Homo sapiens_hsa020100.66851469
46Protein digestion and absorption_Homo sapiens_hsa049740.65971134
47Insulin signaling pathway_Homo sapiens_hsa049100.62285135
48Serotonergic synapse_Homo sapiens_hsa047260.61275308
49Vitamin digestion and absorption_Homo sapiens_hsa049770.60738270
50Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.60680658
51Starch and sucrose metabolism_Homo sapiens_hsa005000.57289022
52Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.57252007
53Insulin secretion_Homo sapiens_hsa049110.56640709
54Nicotine addiction_Homo sapiens_hsa050330.54800969
55Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54619549
56Arachidonic acid metabolism_Homo sapiens_hsa005900.52726930
57Chemical carcinogenesis_Homo sapiens_hsa052040.52656772
58cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52426598
59Peroxisome_Homo sapiens_hsa041460.50565299
60Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.50301218
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.49384134
62Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47544854
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46433757
64beta-Alanine metabolism_Homo sapiens_hsa004100.46142591
65Complement and coagulation cascades_Homo sapiens_hsa046100.45667340
66Oxytocin signaling pathway_Homo sapiens_hsa049210.44968239
67Aldosterone synthesis and secretion_Homo sapiens_hsa049250.40473872
68Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40426062
69Fructose and mannose metabolism_Homo sapiens_hsa000510.39611249
70Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.39529544
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38631530
72Purine metabolism_Homo sapiens_hsa002300.34830168
73Dilated cardiomyopathy_Homo sapiens_hsa054140.34375828
74Arginine biosynthesis_Homo sapiens_hsa002200.34073537
75cAMP signaling pathway_Homo sapiens_hsa040240.33930576
76mTOR signaling pathway_Homo sapiens_hsa041500.33332644
77Cardiac muscle contraction_Homo sapiens_hsa042600.32572338
78Inositol phosphate metabolism_Homo sapiens_hsa005620.32315731
79Renin secretion_Homo sapiens_hsa049240.32133041
80Glycerolipid metabolism_Homo sapiens_hsa005610.32119952
81Salivary secretion_Homo sapiens_hsa049700.31572598
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30810982
83Caffeine metabolism_Homo sapiens_hsa002320.29753135
84Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.29092003
85Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.28430136
86Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.27599971
87Gastric acid secretion_Homo sapiens_hsa049710.27533027
88Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.27463323
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.26688110
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.24968332
91Lysine degradation_Homo sapiens_hsa003100.24763536
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.24217942
93Fatty acid elongation_Homo sapiens_hsa000620.24204760
94Cocaine addiction_Homo sapiens_hsa050300.23757069
95Long-term potentiation_Homo sapiens_hsa047200.23423536
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.23350107
97Type II diabetes mellitus_Homo sapiens_hsa049300.21854941
98Glucagon signaling pathway_Homo sapiens_hsa049220.21447838
99Biosynthesis of amino acids_Homo sapiens_hsa012300.20215531
100SNARE interactions in vesicular transport_Homo sapiens_hsa041300.19568839
101Bile secretion_Homo sapiens_hsa049760.19445658
102Alcoholism_Homo sapiens_hsa050340.18878043
103Chemokine signaling pathway_Homo sapiens_hsa040620.18055093
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.17642231
105AMPK signaling pathway_Homo sapiens_hsa041520.17440917
106HIF-1 signaling pathway_Homo sapiens_hsa040660.16977256
107Amphetamine addiction_Homo sapiens_hsa050310.15781820
108Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.15389938
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.14394162
110Galactose metabolism_Homo sapiens_hsa000520.14288706
111Calcium signaling pathway_Homo sapiens_hsa040200.12981244
112GnRH signaling pathway_Homo sapiens_hsa049120.12816915
113Pancreatic secretion_Homo sapiens_hsa049720.12216133
114Maturity onset diabetes of the young_Homo sapiens_hsa049500.11879121
115Ras signaling pathway_Homo sapiens_hsa040140.11715554
116Vascular smooth muscle contraction_Homo sapiens_hsa042700.11571579
117Collecting duct acid secretion_Homo sapiens_hsa049660.10186695
118Tight junction_Homo sapiens_hsa045300.10094982
119Thyroid hormone synthesis_Homo sapiens_hsa049180.09494773
120mRNA surveillance pathway_Homo sapiens_hsa030150.08612722
121MAPK signaling pathway_Homo sapiens_hsa040100.08348073
122Adipocytokine signaling pathway_Homo sapiens_hsa049200.07950497
123Phospholipase D signaling pathway_Homo sapiens_hsa040720.07882115
124Mineral absorption_Homo sapiens_hsa049780.07724465
125Insulin resistance_Homo sapiens_hsa049310.07333255
126Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.07288898
127Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.06290589
1282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.05682496
129Fat digestion and absorption_Homo sapiens_hsa049750.05530066
130Glioma_Homo sapiens_hsa052140.04957047
131Choline metabolism in cancer_Homo sapiens_hsa052310.04852022
132Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.04578864
133alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.04150084
134Hippo signaling pathway_Homo sapiens_hsa043900.03822711
135Renal cell carcinoma_Homo sapiens_hsa052110.03145946
136Vibrio cholerae infection_Homo sapiens_hsa051100.02909669
137Linoleic acid metabolism_Homo sapiens_hsa005910.02625739
138Endocytosis_Homo sapiens_hsa041440.02293797
139Fatty acid biosynthesis_Homo sapiens_hsa000610.02066240
140Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.01947453
141Taste transduction_Homo sapiens_hsa047420.01756391

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