PRPS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme that catalyzes the phosphoribosylation of ribose 5-phosphate to 5-phosphoribosyl-1-pyrophosphate, which is necessary for purine metabolism and nucleotide biosynthesis. Defects in this gene are a cause of phosphoribosylpyrophosphate synthetase superactivity, Charcot-Marie-Tooth disease X-linked recessive type 5 and Arts Syndrome. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.94404824
2nuclear pore complex assembly (GO:0051292)5.56795245
3ribosome assembly (GO:0042255)5.37741271
4mitotic metaphase plate congression (GO:0007080)5.13457624
5establishment of integrated proviral latency (GO:0075713)5.07914423
6* purine nucleobase biosynthetic process (GO:0009113)5.02659930
7ribosome biogenesis (GO:0042254)5.00975836
8nuclear pore organization (GO:0006999)4.96627857
9folic acid metabolic process (GO:0046655)4.88751914
10mitotic chromosome condensation (GO:0007076)4.86957953
11* nucleobase biosynthetic process (GO:0046112)4.84764140
12DNA replication checkpoint (GO:0000076)4.77868823
13vitamin transmembrane transport (GO:0035461)4.59492549
14rRNA modification (GO:0000154)4.50034925
15DNA deamination (GO:0045006)4.44048649
16protein localization to chromosome, centromeric region (GO:0071459)4.43582025
17proteasome assembly (GO:0043248)4.38991958
18regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.38771792
19heterochromatin organization (GO:0070828)4.38061115
20regulation of spindle organization (GO:0090224)4.33491987
21GMP metabolic process (GO:0046037)4.29994977
22termination of RNA polymerase III transcription (GO:0006386)4.26200638
23transcription elongation from RNA polymerase III promoter (GO:0006385)4.26200638
24ribosomal small subunit biogenesis (GO:0042274)4.18706340
25regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.15483204
26regulation of translational fidelity (GO:0006450)4.11445885
277-methylguanosine mRNA capping (GO:0006370)4.05434164
28anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.01431648
29protein complex localization (GO:0031503)4.00500720
30pore complex assembly (GO:0046931)3.99421797
31metaphase plate congression (GO:0051310)3.96492365
327-methylguanosine RNA capping (GO:0009452)3.95823232
33RNA capping (GO:0036260)3.95823232
34regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.92198591
35positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.91931590
36sister chromatid segregation (GO:0000819)3.87657396
37establishment of viral latency (GO:0019043)3.87012259
38formation of translation preinitiation complex (GO:0001731)3.86942183
39nucleobase-containing small molecule interconversion (GO:0015949)3.82445033
40cellular protein complex localization (GO:0034629)3.81323192
41maturation of 5.8S rRNA (GO:0000460)3.81087595
42folic acid transport (GO:0015884)3.80966820
43transcription elongation from RNA polymerase I promoter (GO:0006362)3.79040944
44negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.77687559
45negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.76264001
46ribonucleoprotein complex biogenesis (GO:0022613)3.76077125
47termination of RNA polymerase I transcription (GO:0006363)3.75743880
48DNA replication initiation (GO:0006270)3.74467043
49spliceosomal snRNP assembly (GO:0000387)3.69257921
50amino acid salvage (GO:0043102)3.65559970
51L-methionine salvage (GO:0071267)3.65559970
52L-methionine biosynthetic process (GO:0071265)3.65559970
53transcription from RNA polymerase I promoter (GO:0006360)3.64304226
54positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.61880901
55rRNA methylation (GO:0031167)3.61804968
56regulation of translation in response to stress (GO:0043555)3.60475897
57rRNA processing (GO:0006364)3.60260124
58regulation of translational termination (GO:0006449)3.54528361
59folic acid-containing compound biosynthetic process (GO:0009396)3.53491737
60rRNA metabolic process (GO:0016072)3.50359107
61maturation of SSU-rRNA (GO:0030490)3.46379513
62guanosine-containing compound biosynthetic process (GO:1901070)3.46041865
63IMP metabolic process (GO:0046040)3.45276753
64telomere maintenance via recombination (GO:0000722)3.43493333
65L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.41830885
66positive regulation of chromosome segregation (GO:0051984)3.41789478
67blastocyst development (GO:0001824)3.40709116
68CENP-A containing nucleosome assembly (GO:0034080)3.39895419
69DNA strand elongation involved in DNA replication (GO:0006271)3.39780005
70pseudouridine synthesis (GO:0001522)3.39543499
71positive regulation of ligase activity (GO:0051351)3.38989073
72negative regulation of ligase activity (GO:0051352)3.37740829
73negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.37740829
74mitotic nuclear envelope disassembly (GO:0007077)3.37715797
75regulation of mitochondrial translation (GO:0070129)3.37082101
76spindle checkpoint (GO:0031577)3.34895642
77protein localization to kinetochore (GO:0034501)3.33650710
78viral transcription (GO:0019083)3.33643206
79mitotic recombination (GO:0006312)3.31661198
80transcription initiation from RNA polymerase I promoter (GO:0006361)3.30352295
81ribosomal small subunit assembly (GO:0000028)3.29732369
82translational termination (GO:0006415)3.28563578
83transcription elongation from RNA polymerase II promoter (GO:0006368)3.28558017
84L-serine metabolic process (GO:0006563)3.26334629
85mitotic sister chromatid cohesion (GO:0007064)3.25345617
86DNA-templated transcription, elongation (GO:0006354)3.24495028
87peptidyl-arginine omega-N-methylation (GO:0035247)3.24375541
88DNA strand elongation (GO:0022616)3.24302543
89mitotic spindle checkpoint (GO:0071174)3.23963628
90regulation of chromosome segregation (GO:0051983)3.23670141
91regulation of mitotic spindle organization (GO:0060236)3.23552058
92DNA replication-independent nucleosome organization (GO:0034724)3.23451656
93DNA replication-independent nucleosome assembly (GO:0006336)3.23451656
94methionine biosynthetic process (GO:0009086)3.22745617
95lung-associated mesenchyme development (GO:0060484)3.22604046
96regulation of ubiquitin-protein transferase activity (GO:0051438)3.21541031
97negative regulation of chromosome segregation (GO:0051985)3.21524911
98IMP biosynthetic process (GO:0006188)3.20706917
99G1/S transition of mitotic cell cycle (GO:0000082)3.20205283
100cell cycle G1/S phase transition (GO:0044843)3.20205283
101chromatin remodeling at centromere (GO:0031055)3.19348784
102negative regulation of mRNA processing (GO:0050686)3.18496687
103negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.18328012
104negative regulation of sister chromatid segregation (GO:0033046)3.18328012
105negative regulation of mitotic sister chromatid separation (GO:2000816)3.18328012
106negative regulation of mitotic sister chromatid segregation (GO:0033048)3.18328012
107pantothenate metabolic process (GO:0015939)3.17587370
108transcription-coupled nucleotide-excision repair (GO:0006283)3.16543257
109chromosome condensation (GO:0030261)3.15372863
110proline biosynthetic process (GO:0006561)3.14789281
111protein deneddylation (GO:0000338)3.14705552
112establishment of chromosome localization (GO:0051303)3.14371992
113membrane disassembly (GO:0030397)3.14329960
114nuclear envelope disassembly (GO:0051081)3.14329960
115mitotic spindle assembly checkpoint (GO:0007094)3.13065449
116regulation of cellular amino acid metabolic process (GO:0006521)3.12935850
117nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.12814359
118regulation of double-strand break repair via homologous recombination (GO:0010569)3.12605125
119intestinal epithelial cell development (GO:0060576)3.12494597
120regulation of nuclear cell cycle DNA replication (GO:0033262)3.12311946
121negative regulation of RNA splicing (GO:0033119)3.11625502
122histone arginine methylation (GO:0034969)3.11163726
123cullin deneddylation (GO:0010388)3.08738799
124histone exchange (GO:0043486)3.08247583
125negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.08201096
126DNA duplex unwinding (GO:0032508)3.08198316
127mitotic sister chromatid segregation (GO:0000070)3.08051058
128methionine metabolic process (GO:0006555)3.07912095
129DNA topological change (GO:0006265)3.06377724
130spindle assembly checkpoint (GO:0071173)3.06241722
131cellular component biogenesis (GO:0044085)3.05600871
132protein maturation by protein folding (GO:0022417)3.05192700
133regulation of ligase activity (GO:0051340)3.04007397
134positive regulation of viral transcription (GO:0050434)3.03792242
135telomere maintenance via semi-conservative replication (GO:0032201)2.99650776
136Golgi transport vesicle coating (GO:0048200)2.99463383
137COPI coating of Golgi vesicle (GO:0048205)2.99463383
138ribosomal large subunit biogenesis (GO:0042273)2.99430073
139double-strand break repair via nonhomologous end joining (GO:0006303)2.94710886
140non-recombinational repair (GO:0000726)2.94710886
141translational initiation (GO:0006413)2.94159557
142paraxial mesoderm development (GO:0048339)2.93483230
143DNA geometric change (GO:0032392)2.93061336
144SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.92587344
145spliceosomal tri-snRNP complex assembly (GO:0000244)2.90737614
146translational elongation (GO:0006414)2.89006467
147chromatin assembly or disassembly (GO:0006333)2.88449855
148nuclear envelope organization (GO:0006998)2.88262572
149negative regulation of mRNA metabolic process (GO:1903312)2.86811965
150cotranslational protein targeting to membrane (GO:0006613)2.85894968
151telomere maintenance via telomere lengthening (GO:0010833)2.84863403
152protein targeting to ER (GO:0045047)2.84766521
153DNA conformation change (GO:0071103)2.81913262
154tRNA aminoacylation for protein translation (GO:0006418)2.80412787
155ATP-dependent chromatin remodeling (GO:0043044)2.80038274
156RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.78883575
157mRNA splicing, via spliceosome (GO:0000398)2.78883575
158DNA packaging (GO:0006323)2.77752312
159nuclear envelope reassembly (GO:0031468)2.77312365
160mitotic nuclear envelope reassembly (GO:0007084)2.77312365
161establishment of protein localization to endoplasmic reticulum (GO:0072599)2.76508479

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.87883881
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.52931507
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.12063432
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.11383576
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.90860372
6ETS1_20019798_ChIP-Seq_JURKAT_Human3.65172743
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.60474871
8* CREB1_15753290_ChIP-ChIP_HEK293T_Human3.43950115
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.43328598
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.28759525
11FOXM1_23109430_ChIP-Seq_U2OS_Human3.20710875
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.00526931
13* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.96066578
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.88731342
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.88274664
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.75645467
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.66917216
18VDR_23849224_ChIP-Seq_CD4+_Human2.63352963
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.53290302
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.48533975
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.37312390
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.36463470
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.31682976
24XRN2_22483619_ChIP-Seq_HELA_Human2.30711326
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.30465807
26GABP_19822575_ChIP-Seq_HepG2_Human2.28046106
27AR_21909140_ChIP-Seq_LNCAP_Human2.27995654
28* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.17297814
29NANOG_18555785_ChIP-Seq_MESCs_Mouse2.14228998
30THAP11_20581084_ChIP-Seq_MESCs_Mouse2.09603367
31MYCN_18555785_ChIP-Seq_MESCs_Mouse2.08439248
32POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.08039854
33FOXP3_21729870_ChIP-Seq_TREG_Human2.07554866
34DCP1A_22483619_ChIP-Seq_HELA_Human2.04339701
35YY1_21170310_ChIP-Seq_MESCs_Mouse2.02927888
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.01048127
37PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.88050675
38EGR1_19374776_ChIP-ChIP_THP-1_Human1.86256786
39KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.81647403
40MYC_22102868_ChIP-Seq_BL_Human1.78804687
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.78758839
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.77659096
43TTF2_22483619_ChIP-Seq_HELA_Human1.74042158
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.72066529
45ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.67990099
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.67065287
47KDM5A_27292631_Chip-Seq_BREAST_Human1.66649298
48E2F1_21310950_ChIP-Seq_MCF-7_Human1.62500867
49ZFX_18555785_ChIP-Seq_MESCs_Mouse1.55448792
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.51562178
51ELF1_17652178_ChIP-ChIP_JURKAT_Human1.51503185
52MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.50161961
53ELK1_19687146_ChIP-ChIP_HELA_Human1.49295094
54CIITA_25753668_ChIP-Seq_RAJI_Human1.47902615
55ZNF263_19887448_ChIP-Seq_K562_Human1.43095184
56KLF4_18555785_ChIP-Seq_MESCs_Mouse1.38852513
57PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.38017582
58NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.36163048
59SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.35420368
60PADI4_21655091_ChIP-ChIP_MCF-7_Human1.35268372
61CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.35073997
62CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.29215880
63* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.28657572
64SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.26689609
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.26549121
66DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.20778673
67ELK1_22589737_ChIP-Seq_MCF10A_Human1.20647764
68NOTCH1_21737748_ChIP-Seq_TLL_Human1.18923726
69BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.18799945
70TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18293034
71POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.18266315
72STAT3_1855785_ChIP-Seq_MESCs_Mouse1.16775373
73* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.12394024
74DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.11602522
75E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.10590520
76TFEB_21752829_ChIP-Seq_HELA_Human1.09037714
77NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.08649355
78CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08586066
79CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.08529067
80HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.08123427
81* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06999461
82CHD1_26751641_Chip-Seq_LNCaP_Human1.06537744
83KAP1_22055183_ChIP-Seq_ESCs_Mouse1.06483093
84CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.04636326
85* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04619957
86SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.04137587
87* CLOCK_20551151_ChIP-Seq_293T_Human1.02729783
88* SOX17_20123909_ChIP-Seq_XEN_Mouse1.00287786
89NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.00175776
90SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.98285800
91* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.98101068
92TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.97948918
93* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.97757480
94TP63_19390658_ChIP-ChIP_HaCaT_Human0.96891017
95KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96465604
96TCF3_18692474_ChIP-Seq_MEFs_Mouse0.96317715
97* NANOG_21062744_ChIP-ChIP_HESCs_Human0.95915861
98ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.94608967
99SALL1_21062744_ChIP-ChIP_HESCs_Human0.93863030
100* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.92635272
101VDR_21846776_ChIP-Seq_THP-1_Human0.91877714
102FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.91871779
103ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.88823790
104* TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.88802479
105* NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.88401400
106ELK3_25401928_ChIP-Seq_HUVEC_Human0.87030647
107GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86936138
108SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.85928257
109ESR1_15608294_ChIP-ChIP_MCF-7_Human0.85469082
110KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.84997223
111NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.84812627
112SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.81547985
113SOX2_18555785_ChIP-Seq_MESCs_Mouse0.80414293
114TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.78593140
115KAP1_27257070_Chip-Seq_ESCs_Mouse0.78473536
116FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77454756
117TBX5_21415370_ChIP-Seq_HL-1_Mouse0.76457019
118* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.76239344
119CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.75978472
120MYC_18940864_ChIP-ChIP_HL60_Human0.75940776
121SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.75589986
122CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.75247681
123* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.74889868

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching7.01810603
2MP0003111_abnormal_nucleus_morphology4.87496894
3MP0004957_abnormal_blastocyst_morpholog4.69450741
4MP0010094_abnormal_chromosome_stability4.14431708
5MP0003718_maternal_effect4.09448265
6MP0003077_abnormal_cell_cycle3.77708364
7MP0008057_abnormal_DNA_replication3.53355206
8MP0008058_abnormal_DNA_repair3.30841825
9MP0003123_paternal_imprinting3.12993119
10MP0008260_abnormal_autophagy3.10942850
11MP0003705_abnormal_hypodermis_morpholog2.88959622
12MP0008932_abnormal_embryonic_tissue2.56880831
13MP0008877_abnormal_DNA_methylation2.56073841
14MP0003786_premature_aging2.52936473
15MP0001730_embryonic_growth_arrest2.43697042
16MP0005623_abnormal_meninges_morphology2.36321943
17MP0008007_abnormal_cellular_replicative2.30725374
18MP0002877_abnormal_melanocyte_morpholog2.27865401
19MP0010030_abnormal_orbit_morphology2.22178362
20MP0010352_gastrointestinal_tract_polyps2.16001271
21MP0003941_abnormal_skin_development2.15181242
22MP0008438_abnormal_cutaneous_collagen2.11555737
23MP0009840_abnormal_foam_cell2.01509896
24MP0000350_abnormal_cell_proliferation1.99884277
25MP0004233_abnormal_muscle_weight1.96574433
26MP0005380_embryogenesis_phenotype1.81828379
27MP0001672_abnormal_embryogenesis/_devel1.81828379
28MP0001661_extended_life_span1.77476184
29MP0005377_hearing/vestibular/ear_phenot1.72536646
30MP0003878_abnormal_ear_physiology1.72536646
31MP0010307_abnormal_tumor_latency1.68869477
32MP0003566_abnormal_cell_adhesion1.66878140
33MP0001697_abnormal_embryo_size1.65261070
34MP0000537_abnormal_urethra_morphology1.64234064
35MP0009333_abnormal_splenocyte_physiolog1.61489319
36MP0002080_prenatal_lethality1.60384081
37MP0006292_abnormal_olfactory_placode1.56484697
38MP0001346_abnormal_lacrimal_gland1.56168669
39MP0003984_embryonic_growth_retardation1.54564327
40MP0002088_abnormal_embryonic_growth/wei1.51166653
41MP0004185_abnormal_adipocyte_glucose1.50558885
42MP0009053_abnormal_anal_canal1.50353909
43MP0003221_abnormal_cardiomyocyte_apopto1.47763426
44MP0002697_abnormal_eye_size1.43302018
45MP0005395_other_phenotype1.37872328
46MP0002210_abnormal_sex_determination1.37650292
47MP0002396_abnormal_hematopoietic_system1.36261780
48MP0000358_abnormal_cell_content/1.34889957
49MP0009697_abnormal_copulation1.30018620
50MP0001348_abnormal_lacrimal_gland1.29909182
51MP0006035_abnormal_mitochondrial_morpho1.28993885
52MP0002085_abnormal_embryonic_tissue1.27974408
53MP0005076_abnormal_cell_differentiation1.27662268
54MP0003315_abnormal_perineum_morphology1.26924922
55MP0006036_abnormal_mitochondrial_physio1.25599504
56MP0002160_abnormal_reproductive_system1.24294697
57MP0001145_abnormal_male_reproductive1.24159823
58MP0001929_abnormal_gametogenesis1.20062841
59MP0002163_abnormal_gland_morphology1.19243630
60MP0003942_abnormal_urinary_system1.18491895
61MP0002653_abnormal_ependyma_morphology1.18323648
62MP0005389_reproductive_system_phenotype1.15505112
63MP0004272_abnormal_basement_membrane1.15223293
64MP0002084_abnormal_developmental_patter1.14367935
65MP0009672_abnormal_birth_weight1.14084053
66MP0003567_abnormal_fetal_cardiomyocyte1.12982388
67MP0002092_abnormal_eye_morphology1.12189003
68MP0000313_abnormal_cell_death1.11401116
69MP0000653_abnormal_sex_gland1.10949124
70MP0001542_abnormal_bone_strength1.09740524
71MP0005379_endocrine/exocrine_gland_phen1.09659394
72MP0003938_abnormal_ear_development1.08630333
73MP0001529_abnormal_vocalization1.07555366
74MP0003385_abnormal_body_wall1.06754053
75MP0002086_abnormal_extraembryonic_tissu1.04959430
76MP0005257_abnormal_intraocular_pressure1.04877515
77MP0009379_abnormal_foot_pigmentation1.04210487
78MP0000750_abnormal_muscle_regeneration1.03821831
79MP0000013_abnormal_adipose_tissue1.02626897
80MP0001764_abnormal_homeostasis1.02488318
81MP0000733_abnormal_muscle_development1.02323047
82MP0002111_abnormal_tail_morphology1.02288885
83MP0001849_ear_inflammation1.01887171
84MP0003879_abnormal_hair_cell1.01352891
85MP0001299_abnormal_eye_distance/1.00640697
86MP0001756_abnormal_urination1.00073862
87MP0001286_abnormal_eye_development0.95636815
88MP0003646_muscle_fatigue0.94648461
89MP0004808_abnormal_hematopoietic_stem0.94231417
90MP0003119_abnormal_digestive_system0.94107941
91MP0005451_abnormal_body_composition0.93337387
92MP0005384_cellular_phenotype0.93221851
93MP0005501_abnormal_skin_physiology0.92250924
94MP0009250_abnormal_appendicular_skeleto0.89276466
95MP0002102_abnormal_ear_morphology0.89237578
96MP0004858_abnormal_nervous_system0.88991276
97MP0000759_abnormal_skeletal_muscle0.87064968
98MP0003121_genomic_imprinting0.86619226
99MP0003115_abnormal_respiratory_system0.86052579
100MP0005621_abnormal_cell_physiology0.86048487
101MP0000432_abnormal_head_morphology0.84313961
102MP0001545_abnormal_hematopoietic_system0.83801655
103MP0005397_hematopoietic_system_phenotyp0.83801655
104MP0002060_abnormal_skin_morphology0.83217906
105MP0003861_abnormal_nervous_system0.82339383
106MP0004084_abnormal_cardiac_muscle0.82292897
107MP0001915_intracranial_hemorrhage0.81001074
108MP0002114_abnormal_axial_skeleton0.80822375
109MP0003890_abnormal_embryonic-extraembry0.80750448
110MP0001919_abnormal_reproductive_system0.80738134
111MP0003699_abnormal_female_reproductive0.80188782
112MP0002019_abnormal_tumor_incidence0.79999757
113MP0002638_abnormal_pupillary_reflex0.78101694
114MP0004264_abnormal_extraembryonic_tissu0.76407083
115MP0002233_abnormal_nose_morphology0.75734036
116MP0002249_abnormal_larynx_morphology0.75293780
117MP0000490_abnormal_crypts_of0.74257078
118MP0010630_abnormal_cardiac_muscle0.72788107
119MP0002161_abnormal_fertility/fecundity0.72717194
120MP0000534_abnormal_ureter_morphology0.72428197
121MP0001881_abnormal_mammary_gland0.71068314
122MP0002876_abnormal_thyroid_physiology0.70714754
123MP0001119_abnormal_female_reproductive0.70055867
124MP0000762_abnormal_tongue_morphology0.69067024
125MP0009703_decreased_birth_body0.68754611
126MP0003698_abnormal_male_reproductive0.68666410
127MP0003806_abnormal_nucleotide_metabolis0.68442403
128MP0000747_muscle_weakness0.68333809
129MP0003755_abnormal_palate_morphology0.67895897
130MP0000003_abnormal_adipose_tissue0.66971845
131MP0004087_abnormal_muscle_fiber0.66521249
132MP0000627_abnormal_mammary_gland0.66238775
133MP0002081_perinatal_lethality0.65440679
134MP0001727_abnormal_embryo_implantation0.64657897
135MP0002132_abnormal_respiratory_system0.64008098
136MP0001340_abnormal_eyelid_morphology0.63741892
137MP0004197_abnormal_fetal_growth/weight/0.62310278
138MP0000428_abnormal_craniofacial_morphol0.61957905
139MP0002269_muscular_atrophy0.61461570
140MP0005220_abnormal_exocrine_pancreas0.61402430
141MP0001944_abnormal_pancreas_morphology0.61246542
142MP0003186_abnormal_redox_activity0.60931993
143MP0002127_abnormal_cardiovascular_syste0.56995449
144MP0004019_abnormal_vitamin_homeostasis0.56146832
145MP0003937_abnormal_limbs/digits/tail_de0.55949987
146MP0004885_abnormal_endolymph0.55329568
147MP0001293_anophthalmia0.54082815
148MP0003656_abnormal_erythrocyte_physiolo0.53603885
149MP0002693_abnormal_pancreas_physiology0.52999403
150MP0003936_abnormal_reproductive_system0.52889252
151MP0004043_abnormal_pH_regulation0.52747762

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)6.34312787
2Breast hypoplasia (HP:0003187)5.78090210
3Cerebral hypomyelination (HP:0006808)4.93185748
4Carpal bone hypoplasia (HP:0001498)4.78397468
5Hyperglycinemia (HP:0002154)4.35611866
6Rough bone trabeculation (HP:0100670)4.31180371
7Impulsivity (HP:0100710)4.04672401
8Patellar aplasia (HP:0006443)3.64997561
9Aplasia/Hypoplasia of the patella (HP:0006498)3.61873741
10Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.42131188
11CNS hypomyelination (HP:0003429)3.39725659
12Hyperglycinuria (HP:0003108)3.38960164
13Secondary amenorrhea (HP:0000869)3.36151715
14Selective tooth agenesis (HP:0001592)3.35321095
15Premature rupture of membranes (HP:0001788)3.31406250
16Oral leukoplakia (HP:0002745)3.28645693
17Abnormality of alanine metabolism (HP:0010916)3.26365321
18Hyperalaninemia (HP:0003348)3.26365321
19Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.26365321
20Abnormality of the labia minora (HP:0012880)3.22976215
21Abnormality of the anterior horn cell (HP:0006802)3.19051209
22Degeneration of anterior horn cells (HP:0002398)3.19051209
23Abnormal trabecular bone morphology (HP:0100671)3.15133797
24Delusions (HP:0000746)3.03747603
25Reticulocytopenia (HP:0001896)3.02048494
26Microretrognathia (HP:0000308)3.00179876
27Premature ovarian failure (HP:0008209)2.98484834
28Entropion (HP:0000621)2.96225043
29Microvesicular hepatic steatosis (HP:0001414)2.87702225
30Dysautonomia (HP:0002459)2.84926631
31Increased nuchal translucency (HP:0010880)2.84874553
32Ureteral duplication (HP:0000073)2.83869021
33Aplasia/Hypoplasia of the sacrum (HP:0008517)2.77716451
34Protrusio acetabuli (HP:0003179)2.76405713
35Absent radius (HP:0003974)2.76357998
36Multiple enchondromatosis (HP:0005701)2.75110347
37Abnormality of glycine metabolism (HP:0010895)2.75002060
38Abnormality of serine family amino acid metabolism (HP:0010894)2.75002060
39Spastic diplegia (HP:0001264)2.72903935
40Unsteady gait (HP:0002317)2.71072002
41Megaloblastic anemia (HP:0001889)2.70217799
42Calcaneovalgus deformity (HP:0001848)2.69729617
43Abnormality of serum amino acid levels (HP:0003112)2.69211464
44Abnormality of cells of the erythroid lineage (HP:0012130)2.68524641
45Abnormal number of incisors (HP:0011064)2.63878531
46Hyperacusis (HP:0010780)2.62364980
47Abnormality of the calcaneus (HP:0008364)2.60991991
48Abnormality of the umbilical cord (HP:0010881)2.60129259
49Aplasia involving forearm bones (HP:0009822)2.58317202
50Absent forearm bone (HP:0003953)2.58317202
51Hypoplasia of the capital femoral epiphysis (HP:0003090)2.55550614
52Insomnia (HP:0100785)2.55466602
53Personality changes (HP:0000751)2.52158225
54Aplasia/Hypoplasia involving the musculature (HP:0001460)2.48078360
55Abnormal spermatogenesis (HP:0008669)2.46932953
56Facial hemangioma (HP:0000329)2.45223284
57Abnormality of the preputium (HP:0100587)2.44630055
58Sparse lateral eyebrow (HP:0005338)2.40985894
59Postnatal microcephaly (HP:0005484)2.40795081
60Irregular epiphyses (HP:0010582)2.38826725
61Atrioventricular block (HP:0001678)2.38545596
62Overriding aorta (HP:0002623)2.37945815
63Shoulder girdle muscle weakness (HP:0003547)2.37495048
64CNS demyelination (HP:0007305)2.36974908
65Pelvic girdle muscle weakness (HP:0003749)2.36416244
66Deformed tarsal bones (HP:0008119)2.34404989
67Cortical dysplasia (HP:0002539)2.33350148
68Meckel diverticulum (HP:0002245)2.32197580
69Horseshoe kidney (HP:0000085)2.32004602
70Ulnar bowing (HP:0003031)2.31859397
71Hyperglycemia (HP:0003074)2.29971609
72Atrophy/Degeneration involving motor neurons (HP:0007373)2.26321147
73Proximal placement of thumb (HP:0009623)2.19903678
74* Progressive muscle weakness (HP:0003323)2.19566725
75Abnormal number of erythroid precursors (HP:0012131)2.18483690
76Capillary hemangiomas (HP:0005306)2.18477235
77Pancreatic cysts (HP:0001737)2.17748382
78Sparse eyelashes (HP:0000653)2.17657875
79Flat capital femoral epiphysis (HP:0003370)2.17173253
80Bone marrow hypocellularity (HP:0005528)2.16836565
81Premature graying of hair (HP:0002216)2.16449844
82Progressive external ophthalmoplegia (HP:0000590)2.16280110
83Abnormality of the ileum (HP:0001549)2.15188728
84Insulin-resistant diabetes mellitus (HP:0000831)2.14322250
85Broad distal phalanx of finger (HP:0009836)2.14113499
86Breast aplasia (HP:0100783)2.13190690
87Deviation of the thumb (HP:0009603)2.12759449
88Vertebral compression fractures (HP:0002953)2.12668901
89Spinal muscular atrophy (HP:0007269)2.12004326
90Achilles tendon contracture (HP:0001771)2.11568242
91Renal duplication (HP:0000075)2.10640886
92* Death in infancy (HP:0001522)2.08993295
93Oligodactyly (hands) (HP:0001180)2.07703678
94Overlapping toe (HP:0001845)2.06853246
95Bundle branch block (HP:0011710)2.06252885
96Restlessness (HP:0000711)2.06050450
97Aplastic anemia (HP:0001915)2.04910895
98Short middle phalanx of the 5th finger (HP:0004220)2.04178632
99Ankle contracture (HP:0006466)2.03874264
100Abnormality of chromosome stability (HP:0003220)2.03658258
101Chromosomal breakage induced by crosslinking agents (HP:0003221)2.02020376
102Nephroblastoma (Wilms tumor) (HP:0002667)2.01823107
103Glossoptosis (HP:0000162)2.01007780
104Neoplasm of the pancreas (HP:0002894)2.00677047
105Abnormality of glycolysis (HP:0004366)2.00395882
106Abnormality of the musculature of the pelvis (HP:0001469)1.99437886
107Abnormality of the hip-girdle musculature (HP:0001445)1.99437886
108Duplication of thumb phalanx (HP:0009942)1.99293141
109Split foot (HP:0001839)1.98721152
110Abnormal umbilical cord blood vessels (HP:0011403)1.98668193
111Single umbilical artery (HP:0001195)1.98668193
112Abnormality of the fetal cardiovascular system (HP:0010948)1.98668193
113Abnormality of dentin (HP:0010299)1.98233675
114Facial cleft (HP:0002006)1.96838124
115Cellular immunodeficiency (HP:0005374)1.96609895
116Aplasia/Hypoplasia of the breasts (HP:0010311)1.96602433
117Glucose intolerance (HP:0000833)1.96119518
118High anterior hairline (HP:0009890)1.95206478
119Ragged-red muscle fibers (HP:0003200)1.95134342
120Embryonal renal neoplasm (HP:0011794)1.94138863
121Missing ribs (HP:0000921)1.93175682
122Emotional lability (HP:0000712)1.92545514
123Absent epiphyses (HP:0010577)1.92054985
124Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.92054985
125Aplasia/Hypoplasia of the uvula (HP:0010293)1.89902914
126Oligodactyly (HP:0012165)1.89766221
127Abnormality of the distal phalanges of the toes (HP:0010182)1.88967503
128Muscle fiber atrophy (HP:0100295)1.88531372
129Ventricular fibrillation (HP:0001663)1.88094144
130Pseudobulbar signs (HP:0002200)1.86847949
131Increased serum pyruvate (HP:0003542)1.86345848
132Global brain atrophy (HP:0002283)1.85592539
133Delayed cranial suture closure (HP:0000270)1.85343314
134Shallow orbits (HP:0000586)1.85236953
135Type 2 muscle fiber atrophy (HP:0003554)1.84883677
136Ependymoma (HP:0002888)1.84593331
137Increased serum lactate (HP:0002151)1.83112414
138Chromsome breakage (HP:0040012)1.81864164
139Abnormality of the tricuspid valve (HP:0001702)1.81428131
140Slender long bone (HP:0003100)1.80836304
141Abnormal autonomic nervous system physiology (HP:0012332)1.80639549
142Trismus (HP:0000211)1.80123321
143Aplasia/hypoplasia of the humerus (HP:0006507)1.79761763
144Pustule (HP:0200039)1.79726544
145Elfin facies (HP:0004428)1.79441958
146Type I transferrin isoform profile (HP:0003642)1.78963193
147Abnormality of the phalanges of the hallux (HP:0010057)1.78040431
148Patent foramen ovale (HP:0001655)1.77860570
149Pallor (HP:0000980)1.76917593
150Abnormality of the Achilles tendon (HP:0005109)1.76379801
151Disproportionate tall stature (HP:0001519)1.76172294
152Orthostatic hypotension (HP:0001278)1.75960089
153Centrally nucleated skeletal muscle fibers (HP:0003687)1.75766494
154Brittle hair (HP:0002299)1.75669246
155Neuroblastic tumors (HP:0004376)1.74319253
156Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.74319253
157Neuroblastoma (HP:0003006)1.74319253
158Primitive neuroectodermal tumor (HP:0030065)1.74319253
159Breech presentation (HP:0001623)1.74303862
160Macrocytic anemia (HP:0001972)1.74132870
161Patellar dislocation (HP:0002999)1.73498262
162Long palpebral fissure (HP:0000637)1.73177494
163Unilateral renal agenesis (HP:0000122)1.70542997
164Atresia of the external auditory canal (HP:0000413)1.69587564
165Deep philtrum (HP:0002002)1.69349231
166Biconcave vertebral bodies (HP:0004586)1.69124192
167Nonimmune hydrops fetalis (HP:0001790)1.68898798
168Syringomyelia (HP:0003396)1.68589838
169Spinal cord lesions (HP:0100561)1.68589838
170Abnormality of cochlea (HP:0000375)1.67156258
171Abnormality of reticulocytes (HP:0004312)1.66288034
172Myelodysplasia (HP:0002863)1.64869040
173Bowel diverticulosis (HP:0005222)1.62581732
174Abnormality of oral frenula (HP:0000190)1.62072181
175Squamous cell carcinoma (HP:0002860)1.61784722
176Ankyloglossia (HP:0010296)1.61421896
177Dysmetric saccades (HP:0000641)1.60093264
178Cholecystitis (HP:0001082)1.59663768
179Abnormal gallbladder physiology (HP:0012438)1.59663768
180Spinal rigidity (HP:0003306)1.58385237
181Dysphonia (HP:0001618)1.56711484
182Arnold-Chiari malformation (HP:0002308)1.54774616
183Abnormal lung lobation (HP:0002101)1.54083329
184Partial duplication of thumb phalanx (HP:0009944)1.52270720
185Cafe-au-lait spot (HP:0000957)1.51237967

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB16.34153204
2WEE14.91054842
3AKT33.73056792
4EIF2AK13.43314935
5TSSK63.31479603
6SMG13.03873995
7STK163.00095460
8BRSK22.93277470
9PLK42.89716450
10VRK22.70572018
11PBK2.65976191
12NEK22.61606377
13CDK122.57557263
14EIF2AK32.42185232
15SRPK12.39171703
16EEF2K2.29043422
17MAP3K102.25637140
18ACVR1B2.21443204
19BRSK12.10967613
20TRIB32.07674433
21NEK12.07662009
22EPHA22.05154988
23PLK31.97488024
24PLK11.95206836
25CCNB11.94681070
26DYRK31.91813708
27TTK1.87985093
28CDC71.80798169
29TAF11.78598255
30MKNK21.62464288
31ICK1.61146113
32ARAF1.55815425
33PNCK1.51109646
34BRAF1.47456534
35PDK31.45691207
36PDK41.45691207
37PRPF4B1.45418369
38NME21.42122274
39MKNK11.35506248
40CHEK21.32234985
41VRK11.29226102
42AURKA1.25858101
43AURKB1.22863089
44ZAK1.21502670
45PINK11.18908872
46LATS21.18689894
47TTN1.18387977
48LATS11.10469392
49PASK1.10007659
50STK38L1.07017433
51IRAK31.02731455
52RPS6KA40.97920842
53CDK70.97368537
54NME10.96642594
55STK40.96098960
56TESK20.95889090
57PDK20.95884584
58PDGFRA0.91636918
59CHEK10.86303506
60TESK10.85713067
61ERBB40.85564498
62PRKCI0.82969322
63BRD40.82730358
64CAMK1G0.81772782
65WNK30.80462841
66ATR0.78987187
67STK30.77509695
68CLK10.77003645
69CAMKK20.76857073
70PRKD30.74577731
71LIMK10.72882405
72PIM20.72514876
73PAK20.71967553
74CSNK1G30.71788968
75CDK60.69513997
76CDK40.69505532
77MTOR0.68606128
78BCKDK0.67680816
79CAMK1D0.67347874
80RAF10.67275483
81MAP3K80.66162767
82EIF2AK20.65851519
83CDK30.65098028
84NTRK10.64886664
85STK100.64597692
86NEK90.64447623
87ALK0.63162924
88LRRK20.62680558
89CDK20.62625016
90DYRK20.59993004
91MAP3K90.59849786
92PTK20.59131168
93KDR0.58877760
94PAK10.58850633
95CDK150.58408049
96BMX0.58362644
97ILK0.56843882
98CSNK2A20.55299398
99CDK90.54986412
100CSNK2A10.54089721
101CDK180.53532592
102DMPK0.52685395
103CDK80.51095202
104CSNK1G10.50057027
105CDK10.45521936
106CSNK1G20.42810141
107CSNK1E0.42289182
108PRKCG0.40352127
109ATM0.40055852
110RPS6KB20.39693225
111CSNK1A1L0.38675411
112STK240.38302407
113ABL20.36721018
114SCYL20.35993363
115MELK0.35279358
116PRKAA10.33319526
117DAPK30.31776549
118TLK10.31534796
119RPS6KA50.27123035
120CSNK1A10.26337252
121PIM10.24167266
122MAP3K50.24108241
123MARK30.22742874
124KSR20.19572510
125DAPK10.19137170
126AKT20.17860287
127KSR10.17199759
128MAPK100.14085606
129GRK50.12061822
130MAPK90.11663777
131MARK10.11471490
132CDK140.10886873
133PRKDC0.10639832
134GSK3B0.09161403
135PAK40.08870935
136TAOK20.07354491
137CDK11A0.06973983
138STK380.06420530

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.48822737
2RNA polymerase_Homo sapiens_hsa030204.59843367
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.51872488
4Proteasome_Homo sapiens_hsa030504.06023552
5RNA transport_Homo sapiens_hsa030133.36499279
6DNA replication_Homo sapiens_hsa030303.31124713
7Mismatch repair_Homo sapiens_hsa034302.76052535
8Pyrimidine metabolism_Homo sapiens_hsa002402.72305669
9Folate biosynthesis_Homo sapiens_hsa007902.65734619
10Spliceosome_Homo sapiens_hsa030402.65162038
11Cell cycle_Homo sapiens_hsa041102.57183751
12Regulation of autophagy_Homo sapiens_hsa041402.44547659
13Nucleotide excision repair_Homo sapiens_hsa034202.26165802
14Homologous recombination_Homo sapiens_hsa034402.25306315
15Basal transcription factors_Homo sapiens_hsa030222.19701250
16Base excision repair_Homo sapiens_hsa034102.13089441
17Ribosome_Homo sapiens_hsa030101.90543885
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.85373363
19Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.70159617
20* Purine metabolism_Homo sapiens_hsa002301.69344001
21p53 signaling pathway_Homo sapiens_hsa041151.57855855
22Fanconi anemia pathway_Homo sapiens_hsa034601.56929641
23Oocyte meiosis_Homo sapiens_hsa041141.48806038
24Cysteine and methionine metabolism_Homo sapiens_hsa002701.45249624
25RNA degradation_Homo sapiens_hsa030181.42930638
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.36324372
27Protein export_Homo sapiens_hsa030601.36081086
28One carbon pool by folate_Homo sapiens_hsa006701.35591186
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.32546173
30Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.32473840
31Glycerophospholipid metabolism_Homo sapiens_hsa005641.30844776
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.30800609
33Pyruvate metabolism_Homo sapiens_hsa006201.30687598
34Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.30264775
35Maturity onset diabetes of the young_Homo sapiens_hsa049501.20039878
36Central carbon metabolism in cancer_Homo sapiens_hsa052301.20035123
37mRNA surveillance pathway_Homo sapiens_hsa030151.17245494
38Epstein-Barr virus infection_Homo sapiens_hsa051691.16473081
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.14814541
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.09621504
41Vitamin digestion and absorption_Homo sapiens_hsa049771.06507700
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.98652855
43Bladder cancer_Homo sapiens_hsa052190.98329289
44Chronic myeloid leukemia_Homo sapiens_hsa052200.96881527
45Circadian rhythm_Homo sapiens_hsa047100.91367877
46Fructose and mannose metabolism_Homo sapiens_hsa000510.91320842
47Non-homologous end-joining_Homo sapiens_hsa034500.89586525
48MicroRNAs in cancer_Homo sapiens_hsa052060.84054348
49* Biosynthesis of amino acids_Homo sapiens_hsa012300.82355356
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.81425053
51Selenocompound metabolism_Homo sapiens_hsa004500.81097927
52Adherens junction_Homo sapiens_hsa045200.79979530
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.79463918
54Sulfur relay system_Homo sapiens_hsa041220.76552366
552-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.74635186
56Basal cell carcinoma_Homo sapiens_hsa052170.74138100
57Hippo signaling pathway_Homo sapiens_hsa043900.73249176
58Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.72328073
59Lysine degradation_Homo sapiens_hsa003100.71331292
60Pancreatic cancer_Homo sapiens_hsa052120.70411398
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.69052613
62Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.66959197
63Huntingtons disease_Homo sapiens_hsa050160.66390631
64Small cell lung cancer_Homo sapiens_hsa052220.65894439
65Colorectal cancer_Homo sapiens_hsa052100.65779349
66Non-small cell lung cancer_Homo sapiens_hsa052230.62346303
67* Pentose phosphate pathway_Homo sapiens_hsa000300.60300686
68Prostate cancer_Homo sapiens_hsa052150.57898312
69Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.57669792
70Wnt signaling pathway_Homo sapiens_hsa043100.57269994
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57253152
72Hedgehog signaling pathway_Homo sapiens_hsa043400.54307416
73* Metabolic pathways_Homo sapiens_hsa011000.54306873
74Fatty acid elongation_Homo sapiens_hsa000620.54273921
75Antigen processing and presentation_Homo sapiens_hsa046120.53289519
76Collecting duct acid secretion_Homo sapiens_hsa049660.52756655
77Shigellosis_Homo sapiens_hsa051310.49655084
78* Carbon metabolism_Homo sapiens_hsa012000.49368751
79Oxidative phosphorylation_Homo sapiens_hsa001900.47387838
80Proteoglycans in cancer_Homo sapiens_hsa052050.46729473
81Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.46178309
82Prion diseases_Homo sapiens_hsa050200.44170952
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43403893
84Endometrial cancer_Homo sapiens_hsa052130.42910283
85Melanoma_Homo sapiens_hsa052180.41476787
86Glioma_Homo sapiens_hsa052140.37814120
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37464311
88Parkinsons disease_Homo sapiens_hsa050120.37429770
89Renal cell carcinoma_Homo sapiens_hsa052110.36853417
90Galactose metabolism_Homo sapiens_hsa000520.35813194
91Alzheimers disease_Homo sapiens_hsa050100.35275409
92Viral carcinogenesis_Homo sapiens_hsa052030.32821093
93N-Glycan biosynthesis_Homo sapiens_hsa005100.32797344
94mTOR signaling pathway_Homo sapiens_hsa041500.32557573
95Arginine and proline metabolism_Homo sapiens_hsa003300.32452991
96Apoptosis_Homo sapiens_hsa042100.32137886
97Cyanoamino acid metabolism_Homo sapiens_hsa004600.31682396
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31487990
99Renin-angiotensin system_Homo sapiens_hsa046140.31315960
100Steroid biosynthesis_Homo sapiens_hsa001000.30074128
101TGF-beta signaling pathway_Homo sapiens_hsa043500.29539784
102Acute myeloid leukemia_Homo sapiens_hsa052210.29091577
103Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.28694529
104Pathways in cancer_Homo sapiens_hsa052000.28052873
105Arginine biosynthesis_Homo sapiens_hsa002200.27651733
106Lysosome_Homo sapiens_hsa041420.27271666
107Glutathione metabolism_Homo sapiens_hsa004800.27065201
108Hepatitis B_Homo sapiens_hsa051610.25621873
109Vibrio cholerae infection_Homo sapiens_hsa051100.20103103
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.19720053
111FoxO signaling pathway_Homo sapiens_hsa040680.19614831
112Herpes simplex infection_Homo sapiens_hsa051680.19604605
113Thyroid cancer_Homo sapiens_hsa052160.18100635
114Synaptic vesicle cycle_Homo sapiens_hsa047210.18025543
115Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.17134348
116Linoleic acid metabolism_Homo sapiens_hsa005910.16985802
117Butanoate metabolism_Homo sapiens_hsa006500.13360264
118Glycerolipid metabolism_Homo sapiens_hsa005610.11666475
119Inositol phosphate metabolism_Homo sapiens_hsa005620.10848790
120HTLV-I infection_Homo sapiens_hsa051660.08015374
121Sphingolipid metabolism_Homo sapiens_hsa006000.06599463
122Arachidonic acid metabolism_Homo sapiens_hsa005900.04238210
123SNARE interactions in vesicular transport_Homo sapiens_hsa041300.01907399
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.00422130
125Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.00316915
126Type I diabetes mellitus_Homo sapiens_hsa049400.00216536
127beta-Alanine metabolism_Homo sapiens_hsa00410-0.0596358
128Alcoholism_Homo sapiens_hsa05034-0.0491387
129Insulin signaling pathway_Homo sapiens_hsa04910-0.0410201
130Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550-0.0379793
131alpha-Linolenic acid metabolism_Homo sapiens_hsa00592-0.0331657
132Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010-0.0324522
133HIF-1 signaling pathway_Homo sapiens_hsa04066-0.0294223
134Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014-0.0277432
135Amphetamine addiction_Homo sapiens_hsa05031-0.0266459
136Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0219626
137Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603-0.0207206
138Legionellosis_Homo sapiens_hsa05134-0.0177251
139Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0142162
140AMPK signaling pathway_Homo sapiens_hsa04152-0.0092060

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