PRPS1P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone H3-K36 demethylation (GO:0070544)4.70938646
2nuclear pore complex assembly (GO:0051292)4.45521794
3histone H3-K9 demethylation (GO:0033169)4.00960476
4mitotic sister chromatid cohesion (GO:0007064)3.87596957
5nuclear pore organization (GO:0006999)3.82422921
6response to muramyl dipeptide (GO:0032495)3.80046115
7negative regulation of erythrocyte differentiation (GO:0045647)3.75223819
8response to peptidoglycan (GO:0032494)3.74909291
9DNA synthesis involved in DNA repair (GO:0000731)3.74728038
10histone lysine demethylation (GO:0070076)3.68344886
11modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.68110705
12positive regulation by organism of defense response of other organism involved in symbiotic interact3.68110705
13modulation by symbiont of host immune response (GO:0052553)3.68110705
14positive regulation by symbiont of host defense response (GO:0052509)3.68110705
15modulation by symbiont of host defense response (GO:0052031)3.68110705
16modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.68110705
17embryonic process involved in female pregnancy (GO:0060136)3.63594625
18histone demethylation (GO:0016577)3.61047950
19positive regulation of gamma-delta T cell activation (GO:0046645)3.58580973
20positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.53049555
21detection of molecule of bacterial origin (GO:0032490)3.39283625
22protein demethylation (GO:0006482)3.37314045
23protein dealkylation (GO:0008214)3.37314045
24regulation of histone H3-K27 methylation (GO:0061085)3.32826262
25mitotic chromosome condensation (GO:0007076)3.28110047
26dosage compensation (GO:0007549)3.27184187
27hepatocyte apoptotic process (GO:0097284)3.26514420
28pore complex assembly (GO:0046931)3.22779159
29germinal center formation (GO:0002467)3.19009504
30histone H3-K4 trimethylation (GO:0080182)3.11522631
31positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.09585159
32positive regulation of granulocyte differentiation (GO:0030854)3.08628095
33macrophage activation involved in immune response (GO:0002281)3.01508190
34negative regulation of cell killing (GO:0031342)2.97331375
35negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.97331375
36negative regulation of DNA repair (GO:0045738)2.96909484
37cellular extravasation (GO:0045123)2.96057573
38spliceosomal tri-snRNP complex assembly (GO:0000244)2.94937187
39regulation of B cell receptor signaling pathway (GO:0050855)2.93880472
40regulation of RNA export from nucleus (GO:0046831)2.93357211
41regulation of interferon-beta biosynthetic process (GO:0045357)2.92746398
42response to laminar fluid shear stress (GO:0034616)2.92563787
43synapsis (GO:0007129)2.89017384
443-UTR-mediated mRNA stabilization (GO:0070935)2.82239812
45B cell receptor signaling pathway (GO:0050853)2.82134919
46regulation of NFAT protein import into nucleus (GO:0051532)2.80806031
47histone H3-K4 methylation (GO:0051568)2.71647526
48negative regulation of interleukin-12 production (GO:0032695)2.70714771
49peptidyl-lysine trimethylation (GO:0018023)2.67241995
50definitive hemopoiesis (GO:0060216)2.67216296
51NIK/NF-kappaB signaling (GO:0038061)2.67076644
52poly(A)+ mRNA export from nucleus (GO:0016973)2.65542735
53histone H4-K16 acetylation (GO:0043984)2.62163336
54histone H3-K9 modification (GO:0061647)2.60471582
55regulation of nucleobase-containing compound transport (GO:0032239)2.58610129
56neutrophil mediated immunity (GO:0002446)2.52668253
57response to host (GO:0075136)2.52007186
58response to host defenses (GO:0052200)2.52007186
59response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.52007186
60T cell migration (GO:0072678)2.50865045
61COPII vesicle coating (GO:0048208)2.49367309
62negative regulation of T cell mediated immunity (GO:0002710)2.48384852
63regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.46095904
64negative regulation of anoikis (GO:2000811)2.43641861
65regulation of necroptotic process (GO:0060544)2.43433342
66antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.43328374
67response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.42623584
68response to host immune response (GO:0052572)2.42623584
69regulation of gamma-delta T cell activation (GO:0046643)2.42249832
70lipopolysaccharide-mediated signaling pathway (GO:0031663)2.42197455
71mRNA stabilization (GO:0048255)2.41776573
72RNA stabilization (GO:0043489)2.41776573
73antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.41554530
74protein export from nucleus (GO:0006611)2.39657508
75B cell homeostasis (GO:0001782)2.38931366
76detection of external biotic stimulus (GO:0098581)2.37527840
77activation of Rac GTPase activity (GO:0032863)2.35788640
78positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.35740997
79cellular protein complex localization (GO:0034629)2.35398135
80leukotriene biosynthetic process (GO:0019370)2.35044518
81cytoplasmic mRNA processing body assembly (GO:0033962)2.32375811
82leukocyte aggregation (GO:0070486)2.30495886
83positive regulation of protein import into nucleus, translocation (GO:0033160)2.29503963
84myeloid leukocyte mediated immunity (GO:0002444)2.29082752
85necroptotic process (GO:0070266)2.27880927
86phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.27523126
87glucocorticoid receptor signaling pathway (GO:0042921)2.27155553
88corticosteroid receptor signaling pathway (GO:0031958)2.26646735
89positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.25156314
90negative regulation of necroptotic process (GO:0060546)2.24899727
91peptidyl-threonine phosphorylation (GO:0018107)2.24432407
92protein localization to chromosome, centromeric region (GO:0071459)2.23729952
93megakaryocyte development (GO:0035855)2.23725125
94detection of other organism (GO:0098543)2.21355202
95negative regulation of phagocytosis (GO:0050765)2.20859136
96nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)2.20083747
97COPI coating of Golgi vesicle (GO:0048205)2.19821419
98Golgi transport vesicle coating (GO:0048200)2.19821419
99energy homeostasis (GO:0097009)2.19418336
100regulation of chromatin binding (GO:0035561)2.19247102

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human4.51518212
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.40973884
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.09991346
4E2F7_22180533_ChIP-Seq_HELA_Human3.99464156
5MYC_22102868_ChIP-Seq_BL_Human3.46324852
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.32159586
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.75985250
8NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.68245495
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.62906699
10MYB_21317192_ChIP-Seq_ERMYB_Mouse2.59378392
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.58083775
12ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.40298821
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.36478090
14VDR_21846776_ChIP-Seq_THP-1_Human2.35556856
15TCF7_22412390_ChIP-Seq_EML_Mouse2.22543602
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.18930181
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.09434136
18MYB_26560356_Chip-Seq_TH2_Human2.06220298
19FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.05024886
20MYB_26560356_Chip-Seq_TH1_Human2.03959168
21IRF8_22096565_ChIP-ChIP_GC-B_Human1.97069325
22MAF_26560356_Chip-Seq_TH1_Human1.95402488
23TFEB_21752829_ChIP-Seq_HELA_Human1.93219737
24KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.91516780
25CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.89683037
26VDR_24763502_ChIP-Seq_THP-1_Human1.89205753
27SPI1_23547873_ChIP-Seq_NB4_Human1.86265148
28IRF8_27001747_Chip-Seq_BMDM_Mouse1.85773401
29BRD4_27068464_Chip-Seq_AML-cells_Mouse1.85707342
30BP1_19119308_ChIP-ChIP_Hs578T_Human1.84362312
31SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.79917575
32KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.79114179
33IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.77636334
34RUNX1_22412390_ChIP-Seq_EML_Mouse1.74943455
35E2F4_17652178_ChIP-ChIP_JURKAT_Human1.69994405
36KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.69569097
37SMAD_19615063_ChIP-ChIP_OVARY_Human1.66524511
38TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.58962317
39STAT4_19710469_ChIP-ChIP_TH1__Mouse1.58563478
40Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.53699655
41IRF8_21731497_ChIP-ChIP_J774_Mouse1.53581179
42CIITA_25753668_ChIP-Seq_RAJI_Human1.53331855
43KDM2B_26808549_Chip-Seq_DND41_Human1.52159794
44KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.48944315
45UTX_26944678_Chip-Seq_JUKART_Human1.48524990
46ELK3_25401928_ChIP-Seq_HUVEC_Human1.46299863
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.44943855
48MAF_26560356_Chip-Seq_TH2_Human1.42115986
49FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.42023302
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.41529096
51TP63_17297297_ChIP-ChIP_HaCaT_Human1.39937703
52CLOCK_20551151_ChIP-Seq_293T_Human1.39645183
53SPI1_23127762_ChIP-Seq_K562_Human1.39016563
54NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.38869789
55SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.38107409
56E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.37784365
57PU_27001747_Chip-Seq_BMDM_Mouse1.36960439
58PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.34738525
59KDM2B_26808549_Chip-Seq_SUP-B15_Human1.34177100
60MYCN_18555785_ChIP-Seq_MESCs_Mouse1.33753369
61RUNX_20019798_ChIP-Seq_JUKART_Human1.33113458
62SCL_19346495_ChIP-Seq_HPC-7_Human1.33088157
63TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.32018129
64VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.32016542
65RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.30012740
66SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.28550504
67CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.26623252
68DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.26331557
69CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.24973152
70BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.23772268
71GATA1_22025678_ChIP-Seq_K562_Human1.21706265
72DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.21273019
73VDR_24787735_ChIP-Seq_THP-1_Human1.20285015
74GATA2_22383799_ChIP-Seq_G1ME_Mouse1.20135626
75TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17233253
76E2F1_21310950_ChIP-Seq_MCF-7_Human1.16645311
77ZFX_18555785_ChIP-Seq_MESCs_Mouse1.16220688
78KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15729144
79CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.14265420
80KDM2B_26808549_Chip-Seq_JURKAT_Human1.13197799
81NCOR1_26117541_ChIP-Seq_K562_Human1.12249484
82FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.12224711
83TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.10396938
84NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.10187718
85SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.09985126
86SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.09985126
87DCP1A_22483619_ChIP-Seq_HELA_Human1.08128825
88GATA3_27048872_Chip-Seq_THYMUS_Human1.06331640
89CHD1_26751641_Chip-Seq_LNCaP_Human1.06076137
90MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.05131379
91GATA1_22383799_ChIP-Seq_G1ME_Mouse1.04350732
92FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.03906423
93GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.03393527
94NOTCH1_21737748_ChIP-Seq_TLL_Human1.02343790
95NELFA_20434984_ChIP-Seq_ESCs_Mouse1.02223949
96WT1_19549856_ChIP-ChIP_CCG9911_Human1.01909704
97ERG_20887958_ChIP-Seq_HPC-7_Mouse1.01791722
98HOXB4_20404135_ChIP-ChIP_EML_Mouse1.01293004
99TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00011218
100RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.99872338

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002009_preneoplasia2.94893295
2MP0005451_abnormal_body_composition2.89152768
3MP0003436_decreased_susceptibility_to2.59839680
4MP0003300_gastrointestinal_ulcer2.59415288
5MP0008260_abnormal_autophagy2.45068423
6MP0008057_abnormal_DNA_replication2.44453507
7MP0003656_abnormal_erythrocyte_physiolo2.43545228
8MP0002877_abnormal_melanocyte_morpholog2.42652625
9MP0002166_altered_tumor_susceptibility2.41716091
10MP0005076_abnormal_cell_differentiation2.37166819
11MP0003303_peritoneal_inflammation2.37124765
12MP0010352_gastrointestinal_tract_polyps2.33627562
13MP0001835_abnormal_antigen_presentation2.19198494
14MP0002396_abnormal_hematopoietic_system2.02219829
15MP0003763_abnormal_thymus_physiology2.01385366
16MP0004808_abnormal_hematopoietic_stem1.96568735
17MP0003724_increased_susceptibility_to1.96283160
18MP0003221_abnormal_cardiomyocyte_apopto1.88634387
19MP0010234_abnormal_vibrissa_follicle1.87138533
20MP0003172_abnormal_lysosome_physiology1.84380895
21MP0001800_abnormal_humoral_immune1.80788760
22MP0003091_abnormal_cell_migration1.73764323
23MP0002398_abnormal_bone_marrow1.71245512
24MP0002006_tumorigenesis1.68549539
25MP0001853_heart_inflammation1.65534173
26MP0005000_abnormal_immune_tolerance1.59771564
27MP0003705_abnormal_hypodermis_morpholog1.59642935
28MP0003828_pulmonary_edema1.57885079
29MP0002419_abnormal_innate_immunity1.54251484
30MP0000703_abnormal_thymus_morphology1.51679611
31MP0002452_abnormal_antigen_presenting1.51476235
32MP0002420_abnormal_adaptive_immunity1.48371714
33MP0002723_abnormal_immune_serum1.46748186
34MP0004947_skin_inflammation1.45972787
35MP0001819_abnormal_immune_cell1.45062406
36MP0002405_respiratory_system_inflammati1.44744378
37MP0004233_abnormal_muscle_weight1.42782740
38MP0000716_abnormal_immune_system1.41702828
39MP0000858_altered_metastatic_potential1.38040006
40MP0000685_abnormal_immune_system1.36954409
41MP0002722_abnormal_immune_system1.35547098
42MP0003191_abnormal_cellular_cholesterol1.35412827
43MP0005387_immune_system_phenotype1.30921396
44MP0001790_abnormal_immune_system1.30921396
45MP0003111_abnormal_nucleus_morphology1.30266497
46MP0000733_abnormal_muscle_development1.29617235
47MP0010094_abnormal_chromosome_stability1.28641783
48MP0000689_abnormal_spleen_morphology1.28520860
49MP0003077_abnormal_cell_cycle1.24428967
50MP0010307_abnormal_tumor_latency1.24199250
51MP0001730_embryonic_growth_arrest1.23805362
52MP0002429_abnormal_blood_cell1.23650648
53MP0005397_hematopoietic_system_phenotyp1.20849340
54MP0001545_abnormal_hematopoietic_system1.20849340
55MP0004381_abnormal_hair_follicle1.20627619
56MP0004185_abnormal_adipocyte_glucose1.19957939
57MP0005025_abnormal_response_to1.15435110
58MP0005621_abnormal_cell_physiology1.15375774
59MP0009333_abnormal_splenocyte_physiolog1.15310892
60MP0003566_abnormal_cell_adhesion1.13537497
61MP0001851_eye_inflammation1.12834525
62MP0010678_abnormal_skin_adnexa1.10318246
63MP0000350_abnormal_cell_proliferation1.09940190
64MP0009278_abnormal_bone_marrow1.08475796
65MP0008961_abnormal_basal_metabolism1.05442415
66MP0002132_abnormal_respiratory_system1.05376902
67MP0003984_embryonic_growth_retardation1.04984954
68MP0008007_abnormal_cellular_replicative1.04342325
69MP0000465_gastrointestinal_hemorrhage1.04218911
70MP0002998_abnormal_bone_remodeling1.02779007
71MP0005058_abnormal_lysosome_morphology0.99357457
72MP0003693_abnormal_embryo_hatching0.98165445
73MP0001533_abnormal_skeleton_physiology0.97719072
74MP0002088_abnormal_embryonic_growth/wei0.97612377
75MP0005464_abnormal_platelet_physiology0.97368511
76MP0005310_abnormal_salivary_gland0.97353897
77MP0002086_abnormal_extraembryonic_tissu0.95415833
78MP0010155_abnormal_intestine_physiology0.95031842
79MP0002019_abnormal_tumor_incidence0.94197631
80MP0003453_abnormal_keratinocyte_physiol0.93832901
81MP0004197_abnormal_fetal_growth/weight/0.93771925
82MP0001915_intracranial_hemorrhage0.93061124
83MP0005671_abnormal_response_to0.92513882
84MP0009764_decreased_sensitivity_to0.89854211
85MP0009703_decreased_birth_body0.89806428
86MP0005380_embryogenesis_phenotype0.89375940
87MP0001672_abnormal_embryogenesis/_devel0.89375940
88MP0000313_abnormal_cell_death0.88375996
89MP0005384_cellular_phenotype0.87801625
90MP0006054_spinal_hemorrhage0.86695955
91MP0000383_abnormal_hair_follicle0.85643372
92MP0009785_altered_susceptibility_to0.84224584
93MP0003786_premature_aging0.83694635
94MP0001845_abnormal_inflammatory_respons0.83169883
95MP0004264_abnormal_extraembryonic_tissu0.80497382
96MP0004957_abnormal_blastocyst_morpholog0.79024842
97MP0001873_stomach_inflammation0.78424513
98MP0003448_altered_tumor_morphology0.77800603
99MP0003183_abnormal_peptide_metabolism0.77234778
100MP0000003_abnormal_adipose_tissue0.76675360

Predicted human phenotypes

RankGene SetZ-score
1Spinal cord lesions (HP:0100561)3.85257685
2Syringomyelia (HP:0003396)3.85257685
3Asymmetry of the thorax (HP:0001555)3.07739655
4Recurrent viral infections (HP:0004429)2.94447038
5Abnormality of the fingertips (HP:0001211)2.87160753
6Viral hepatitis (HP:0006562)2.84681527
7Subacute progressive viral hepatitis (HP:0006572)2.84648109
8Shoulder girdle muscle weakness (HP:0003547)2.79703174
9Fatigue (HP:0012378)2.78432023
10Pelvic girdle muscle weakness (HP:0003749)2.67421574
11Broad face (HP:0000283)2.53310845
12Slow saccadic eye movements (HP:0000514)2.47475532
13Eczematoid dermatitis (HP:0000976)2.45216457
14Abnormal delayed hypersensitivity skin test (HP:0002963)2.38541381
15Long eyelashes (HP:0000527)2.35155757
16Abnormality of the musculature of the pelvis (HP:0001469)2.32452854
17Abnormality of the hip-girdle musculature (HP:0001445)2.32452854
18Deep philtrum (HP:0002002)2.32183913
19Colitis (HP:0002583)2.30742079
20Chronic mucocutaneous candidiasis (HP:0002728)2.29404853
21Recurrent cutaneous fungal infections (HP:0011370)2.29404853
22Recurrent bacterial skin infections (HP:0005406)2.28788827
23Transitional cell carcinoma of the bladder (HP:0006740)2.28492839
24Recurrent fungal infections (HP:0002841)2.24684334
25Symptomatic seizures (HP:0011145)2.22125494
26Cellulitis (HP:0100658)2.16921636
27Subaortic stenosis (HP:0001682)2.15166692
28Abnormality of the left ventricular outflow tract (HP:0011103)2.15166692
29Bladder carcinoma (HP:0002862)2.12223717
30Bladder neoplasm (HP:0009725)2.12223717
31Recurrent abscess formation (HP:0002722)2.12024136
32Chest pain (HP:0100749)2.11451816
33Spondylolisthesis (HP:0003302)2.08065302
34Cutaneous melanoma (HP:0012056)2.08009690
35Uterine leiomyosarcoma (HP:0002891)2.07730473
36Leiomyosarcoma (HP:0100243)2.07730473
37Micronodular cirrhosis (HP:0001413)2.05960008
38Prominent nose (HP:0000448)2.01996755
39Rimmed vacuoles (HP:0003805)2.00360742
40Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.96906452
41Difficulty running (HP:0009046)1.94866204
42T lymphocytopenia (HP:0005403)1.94494212
43Mediastinal lymphadenopathy (HP:0100721)1.92671871
44Absent frontal sinuses (HP:0002688)1.92081456
45Renal cell carcinoma (HP:0005584)1.91915671
46Termporal pattern (HP:0011008)1.90233079
47Insidious onset (HP:0003587)1.90233079
48Panhypogammaglobulinemia (HP:0003139)1.89202954
49Sparse lateral eyebrow (HP:0005338)1.88342455
50Papillary thyroid carcinoma (HP:0002895)1.88038666
51Gastrointestinal inflammation (HP:0004386)1.86724503
52Inflammation of the large intestine (HP:0002037)1.85131852
53Curly hair (HP:0002212)1.85124901
54Thyroid carcinoma (HP:0002890)1.84487842
55Meningitis (HP:0001287)1.84457970
56Hypoglycemic seizures (HP:0002173)1.83249704
57Recurrent skin infections (HP:0001581)1.82944093
58Sandal gap (HP:0001852)1.79900051
59Vasculitis (HP:0002633)1.78210668
60Limb-girdle muscle weakness (HP:0003325)1.77787134
61Basal cell carcinoma (HP:0002671)1.77755335
62Gastrointestinal infarctions (HP:0005244)1.76326771
63Neonatal hypoglycemia (HP:0001998)1.75101287
64Spontaneous hematomas (HP:0007420)1.74878761
65Flat acetabular roof (HP:0003180)1.74811334
66Abnormality of T cell number (HP:0011839)1.73773851
67Centrally nucleated skeletal muscle fibers (HP:0003687)1.73192215
68Somatic mutation (HP:0001428)1.72726043
69Progressive hearing impairment (HP:0001730)1.72584921
70Upper motor neuron abnormality (HP:0002127)1.72291091
71Arterial thrombosis (HP:0004420)1.72264345
72Lower limb hyperreflexia (HP:0002395)1.72058559
73Malignant gastrointestinal tract tumors (HP:0006749)1.71885459
74Gastrointestinal carcinoma (HP:0002672)1.71885459
75Overlapping toe (HP:0001845)1.71819874
76Hepatitis (HP:0012115)1.71819168
77Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.70820280
78Macroorchidism (HP:0000053)1.70205596
79Thoracolumbar scoliosis (HP:0002944)1.69670897
80Low anterior hairline (HP:0000294)1.69531836
81Increased connective tissue (HP:0009025)1.67956584
82Abnormality of macrophages (HP:0004311)1.67824830
83Granulocytopenia (HP:0001913)1.67009678
84Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.66366961
85Elevated erythrocyte sedimentation rate (HP:0003565)1.64635902
86Thick nail (HP:0001805)1.63200687
87Prominent metopic ridge (HP:0005487)1.62030254
88Acute myeloid leukemia (HP:0004808)1.61849310
89Interstitial pulmonary disease (HP:0006530)1.61792484
90Abnormality of T cell physiology (HP:0011840)1.61269259
91Acute hepatic failure (HP:0006554)1.61076840
92Autoimmune hemolytic anemia (HP:0001890)1.60960948
93Long palpebral fissure (HP:0000637)1.60886655
94Dislocated radial head (HP:0003083)1.60691820
95Distal lower limb amyotrophy (HP:0008944)1.60348354
96Progressive sensorineural hearing impairment (HP:0000408)1.59868573
97Rhabdomyosarcoma (HP:0002859)1.59621263
98Narrow palate (HP:0000189)1.59083863
99Orchitis (HP:0100796)1.58376036
100Progressive external ophthalmoplegia (HP:0000590)1.57606650

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B3.87068544
2SIK32.99656915
3RIPK42.79457235
4CDK122.74380808
5BRD42.44766805
6MAP2K32.27264055
7MAP3K142.19343663
8TRIB31.93904959
9IRAK41.92098696
10STK241.84717347
11MAP4K11.77256300
12SIK11.77207698
13BMPR21.75579861
14BLK1.70675223
15CDK61.69147760
16SCYL21.66750431
17KSR21.64412486
18IRAK31.59278048
19SMG11.57154395
20MAP3K101.54233391
21PDGFRA1.53573882
22EPHB11.49379585
23TTN1.47864849
24IRAK21.44861290
25IRAK11.44119037
26ERN11.35624364
27ZAP701.30580663
28MAP3K131.27314458
29TYK21.27097892
30NEK91.25402672
31SIK21.23894483
32MOS1.20985734
33ICK1.20022188
34YES11.18895705
35INSRR1.17248556
36MELK1.16311732
37PASK1.11962015
38CSK1.10013906
39STK101.07629704
40EEF2K1.07497006
41RPS6KA41.05711601
42IKBKE1.04542182
43JAK31.03776889
44FGFR31.03694789
45NEK11.01684203
46CAMK1D0.93730642
47JAK10.93542782
48JAK20.92917618
49BTK0.91168981
50CDK40.90910724
51PDGFRB0.90305811
52EIF2AK30.89547271
53KSR10.89410053
54MAP3K20.88577424
55SGK30.87555570
56TAOK20.86943087
57TSSK60.86682287
58HCK0.86564891
59CLK10.85827628
60DYRK30.85677031
61MARK30.85397288
62FGR0.84981382
63MARK20.82569913
64CAMK1G0.81075910
65TAOK10.79374064
66FGFR40.77449757
67CHUK0.76868631
68CSF1R0.73769351
69GRK60.68054114
70RET0.68007257
71MTOR0.67536968
72MAPK110.66853228
73RAF10.66434055
74STK38L0.65862886
75MAP3K60.65623561
76ERBB40.64540652
77DYRK1B0.63601981
78MAP3K30.63599774
79CDK90.62268888
80ALK0.61848014
81MET0.61845105
82MAP3K80.58617042
83TRPM70.58152308
84CDC42BPA0.58122980
85MAPK70.58060567
86MAP3K50.57295599
87PAK40.56721666
88EIF2AK10.56563245
89TBK10.54795863
90SYK0.54435449
91RPS6KB20.52254206
92CHEK10.52066276
93PTK60.52010335
94MAP3K10.50745650
95CDK70.50295795
96LRRK20.49032388
97CAMK40.47536941
98PIK3CG0.45470852
99WNK10.44937630
100LATS10.44925054

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-small cell lung cancer_Homo sapiens_hsa052232.22362841
2B cell receptor signaling pathway_Homo sapiens_hsa046622.21361520
3Chronic myeloid leukemia_Homo sapiens_hsa052202.09086224
4Acute myeloid leukemia_Homo sapiens_hsa052211.90701101
5Osteoclast differentiation_Homo sapiens_hsa043801.89837148
6Hepatitis B_Homo sapiens_hsa051611.75409408
7Toll-like receptor signaling pathway_Homo sapiens_hsa046201.71185639
8Other glycan degradation_Homo sapiens_hsa005111.69735781
9Pancreatic cancer_Homo sapiens_hsa052121.69118328
10Measles_Homo sapiens_hsa051621.68984813
11Prostate cancer_Homo sapiens_hsa052151.62269352
12Endometrial cancer_Homo sapiens_hsa052131.60906711
13Leishmaniasis_Homo sapiens_hsa051401.60041226
14T cell receptor signaling pathway_Homo sapiens_hsa046601.55830838
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.55100433
16Prolactin signaling pathway_Homo sapiens_hsa049171.52441275
17Renal cell carcinoma_Homo sapiens_hsa052111.51964870
18Influenza A_Homo sapiens_hsa051641.51112275
19Thyroid cancer_Homo sapiens_hsa052161.45822183
20Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.44158789
21TNF signaling pathway_Homo sapiens_hsa046681.42477900
22Neurotrophin signaling pathway_Homo sapiens_hsa047221.40703828
23Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.39411902
24Viral carcinogenesis_Homo sapiens_hsa052031.38164102
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.38114174
26Herpes simplex infection_Homo sapiens_hsa051681.37274599
27mTOR signaling pathway_Homo sapiens_hsa041501.35228092
28AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.32083329
29FoxO signaling pathway_Homo sapiens_hsa040681.31750846
30Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.28719806
31Glioma_Homo sapiens_hsa052141.28216113
32Inositol phosphate metabolism_Homo sapiens_hsa005621.27898826
33Toxoplasmosis_Homo sapiens_hsa051451.26438282
34Bladder cancer_Homo sapiens_hsa052191.26366866
35Small cell lung cancer_Homo sapiens_hsa052221.25782544
36Tuberculosis_Homo sapiens_hsa051521.25421636
37Thyroid hormone signaling pathway_Homo sapiens_hsa049191.25393576
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.24158953
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.23686637
40Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.23457430
41VEGF signaling pathway_Homo sapiens_hsa043701.21379042
42Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.17131504
43Apoptosis_Homo sapiens_hsa042101.16063027
44Lysine degradation_Homo sapiens_hsa003101.13400807
45Legionellosis_Homo sapiens_hsa051341.12650217
46Hepatitis C_Homo sapiens_hsa051601.11656756
47Colorectal cancer_Homo sapiens_hsa052101.09747179
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.08890133
49Jak-STAT signaling pathway_Homo sapiens_hsa046301.08203538
50Central carbon metabolism in cancer_Homo sapiens_hsa052301.05617281
51Choline metabolism in cancer_Homo sapiens_hsa052311.05053411
52Notch signaling pathway_Homo sapiens_hsa043301.03543714
53ErbB signaling pathway_Homo sapiens_hsa040121.02999457
54mRNA surveillance pathway_Homo sapiens_hsa030151.02297952
55Shigellosis_Homo sapiens_hsa051311.02017945
56Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.98106692
57MicroRNAs in cancer_Homo sapiens_hsa052060.97057169
58Longevity regulating pathway - mammal_Homo sapiens_hsa042110.96673349
59Cell cycle_Homo sapiens_hsa041100.96315629
60Leukocyte transendothelial migration_Homo sapiens_hsa046700.96008558
61Epstein-Barr virus infection_Homo sapiens_hsa051690.94071765
62HIF-1 signaling pathway_Homo sapiens_hsa040660.90940728
63HTLV-I infection_Homo sapiens_hsa051660.90868120
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.90756648
65Malaria_Homo sapiens_hsa051440.90325732
66Circadian rhythm_Homo sapiens_hsa047100.89231400
67Insulin resistance_Homo sapiens_hsa049310.88389921
68Non-homologous end-joining_Homo sapiens_hsa034500.86674304
69Adherens junction_Homo sapiens_hsa045200.86538960
70Proteoglycans in cancer_Homo sapiens_hsa052050.85738430
71Chemokine signaling pathway_Homo sapiens_hsa040620.85161180
72Type II diabetes mellitus_Homo sapiens_hsa049300.83839663
73Insulin signaling pathway_Homo sapiens_hsa049100.83541693
74Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.82054777
75Primary immunodeficiency_Homo sapiens_hsa053400.81387220
76Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.79447035
77Estrogen signaling pathway_Homo sapiens_hsa049150.79396841
78p53 signaling pathway_Homo sapiens_hsa041150.75951093
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.75277087
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.74856663
81Platelet activation_Homo sapiens_hsa046110.74358873
82GnRH signaling pathway_Homo sapiens_hsa049120.74082189
83Viral myocarditis_Homo sapiens_hsa054160.70048907
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68617691
85Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.65774179
86Spliceosome_Homo sapiens_hsa030400.65311868
87Focal adhesion_Homo sapiens_hsa045100.63609955
88AMPK signaling pathway_Homo sapiens_hsa041520.61469812
89Amoebiasis_Homo sapiens_hsa051460.59311864
90Hematopoietic cell lineage_Homo sapiens_hsa046400.57923505
91Melanoma_Homo sapiens_hsa052180.56904170
92Salmonella infection_Homo sapiens_hsa051320.56151785
93MAPK signaling pathway_Homo sapiens_hsa040100.55490722
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.54948499
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53965696
96Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.52747936
97Dorso-ventral axis formation_Homo sapiens_hsa043200.51971150
98Antigen processing and presentation_Homo sapiens_hsa046120.49939451
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49904542
100Long-term potentiation_Homo sapiens_hsa047200.48331509

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