PRPSAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.25121252
2behavioral response to nicotine (GO:0035095)4.43302767
3ribosomal small subunit assembly (GO:0000028)4.31365985
4viral transcription (GO:0019083)4.25681550
5translational termination (GO:0006415)4.15995516
6formation of translation preinitiation complex (GO:0001731)4.13273031
7maturation of SSU-rRNA (GO:0030490)4.13159902
8nucleobase biosynthetic process (GO:0046112)4.02778686
9purine nucleobase biosynthetic process (GO:0009113)3.90182062
10ribosomal small subunit biogenesis (GO:0042274)3.85860667
11DNA strand elongation involved in DNA replication (GO:0006271)3.85044480
12translational elongation (GO:0006414)3.82034462
13folic acid metabolic process (GO:0046655)3.79577975
14folic acid-containing compound biosynthetic process (GO:0009396)3.79566710
15piRNA metabolic process (GO:0034587)3.74136806
16proteasome assembly (GO:0043248)3.73454622
17translational initiation (GO:0006413)3.66960699
18DNA strand elongation (GO:0022616)3.65654206
19SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.64635269
20protein-cofactor linkage (GO:0018065)3.64025962
21telomere maintenance via semi-conservative replication (GO:0032201)3.63530186
22L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.62279902
23pteridine-containing compound biosynthetic process (GO:0042559)3.60792171
24cotranslational protein targeting to membrane (GO:0006613)3.55892139
25ribosomal large subunit biogenesis (GO:0042273)3.54944779
26ribonucleoprotein complex biogenesis (GO:0022613)3.54673911
27protein targeting to ER (GO:0045047)3.54147644
28ribosome assembly (GO:0042255)3.52941989
29ribosome biogenesis (GO:0042254)3.51413899
30glycine metabolic process (GO:0006544)3.48340880
31serine family amino acid biosynthetic process (GO:0009070)3.43148116
32L-methionine salvage (GO:0071267)3.41418160
33L-methionine biosynthetic process (GO:0071265)3.41418160
34amino acid salvage (GO:0043102)3.41418160
35protein localization to endoplasmic reticulum (GO:0070972)3.40024891
36DNA replication initiation (GO:0006270)3.37725490
37establishment of protein localization to endoplasmic reticulum (GO:0072599)3.34319303
38nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.34059165
39pseudouridine synthesis (GO:0001522)3.32819446
40L-serine metabolic process (GO:0006563)3.31859748
41erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.29940059
42L-phenylalanine catabolic process (GO:0006559)3.29940059
43viral life cycle (GO:0019058)3.26907603
44cellular protein complex disassembly (GO:0043624)3.22122944
45DNA unwinding involved in DNA replication (GO:0006268)3.21631589
46deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.18732076
47cysteine metabolic process (GO:0006534)3.12156649
48regulation of cilium movement (GO:0003352)3.10694142
49proline biosynthetic process (GO:0006561)3.06880825
50translation (GO:0006412)3.06701391
51rRNA processing (GO:0006364)3.06541033
52telomere maintenance via recombination (GO:0000722)3.06214828
53mitotic metaphase plate congression (GO:0007080)3.02716663
54negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.01773673
55nucleoside salvage (GO:0043174)3.01723348
56spliceosomal snRNP assembly (GO:0000387)2.99750750
57rRNA metabolic process (GO:0016072)2.99419123
58sulfur amino acid biosynthetic process (GO:0000097)2.97999216
59DNA methylation involved in gamete generation (GO:0043046)2.96163705
60rRNA modification (GO:0000154)2.94532253
61anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.93446735
62protein complex disassembly (GO:0043241)2.93433977
63GDP-mannose metabolic process (GO:0019673)2.93330337
64telomere maintenance via telomere lengthening (GO:0010833)2.92218197
65mannosylation (GO:0097502)2.91069570
66regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.90441934
67mitochondrial respiratory chain complex I assembly (GO:0032981)2.90261080
68NADH dehydrogenase complex assembly (GO:0010257)2.90261080
69mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.90261080
70cellular component biogenesis (GO:0044085)2.89030939
71DNA replication-dependent nucleosome assembly (GO:0006335)2.87962333
72DNA replication-dependent nucleosome organization (GO:0034723)2.87962333
73positive regulation of mitochondrial fission (GO:0090141)2.87877516
74DNA replication checkpoint (GO:0000076)2.87481881
75positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.86928917
76methionine biosynthetic process (GO:0009086)2.85513054
77water-soluble vitamin biosynthetic process (GO:0042364)2.85362929
78serine family amino acid metabolic process (GO:0009069)2.83646023
79transcription elongation from RNA polymerase III promoter (GO:0006385)2.83500407
80termination of RNA polymerase III transcription (GO:0006386)2.83500407
81mitochondrial RNA metabolic process (GO:0000959)2.81225820
82pteridine-containing compound metabolic process (GO:0042558)2.81208789
83negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.81187912
84negative regulation of ligase activity (GO:0051352)2.81187912
85mitotic recombination (GO:0006312)2.80923008
86macromolecular complex disassembly (GO:0032984)2.79560310
87S-adenosylmethionine metabolic process (GO:0046500)2.79224210
88metaphase plate congression (GO:0051310)2.79218987
89pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.78818496
90serine family amino acid catabolic process (GO:0009071)2.78033338
91mitotic nuclear envelope disassembly (GO:0007077)2.74996757
92folic acid-containing compound metabolic process (GO:0006760)2.74771930
93chromatin remodeling at centromere (GO:0031055)2.71915786
94protein complex biogenesis (GO:0070271)2.70718683
95negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.70609758
96methionine metabolic process (GO:0006555)2.69794094
97protein carboxylation (GO:0018214)2.68626567
98peptidyl-glutamic acid carboxylation (GO:0017187)2.68626567
99aspartate family amino acid biosynthetic process (GO:0009067)2.68565799
100CENP-A containing nucleosome assembly (GO:0034080)2.67699029
101pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.67626561
102epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.66360159
103nuclear-transcribed mRNA catabolic process (GO:0000956)2.64873848
104RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.64437724
105tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.64437724
106erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.63750082
107L-phenylalanine metabolic process (GO:0006558)2.63750082
108maturation of 5.8S rRNA (GO:0000460)2.63493948
109cellular metabolic compound salvage (GO:0043094)2.62953217
110peptidyl-glutamic acid modification (GO:0018200)2.61610428
111tetrahydrofolate metabolic process (GO:0046653)2.61526519
112arginine metabolic process (GO:0006525)2.60739237
113preassembly of GPI anchor in ER membrane (GO:0016254)2.60464372
114protein complex localization (GO:0031503)2.60223507
115IMP biosynthetic process (GO:0006188)2.58943096
116regulation of microtubule-based movement (GO:0060632)2.58378271
117intestinal cholesterol absorption (GO:0030299)2.58224219
118pyrimidine nucleoside salvage (GO:0043097)2.57710809
119pyrimidine-containing compound salvage (GO:0008655)2.57710809
120aromatic amino acid family catabolic process (GO:0009074)2.57551843
121mitochondrial respiratory chain complex assembly (GO:0033108)2.55959864
122nucleotide-excision repair, DNA gap filling (GO:0006297)2.54903439
123positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.54311210
124aldehyde catabolic process (GO:0046185)2.52995081
125transcription-coupled nucleotide-excision repair (GO:0006283)2.52866092
126epithelial cilium movement (GO:0003351)2.52677272
127high-density lipoprotein particle remodeling (GO:0034375)2.51259530
128mRNA catabolic process (GO:0006402)2.50216570
129RNA catabolic process (GO:0006401)2.49905314
130regulation of translation in response to stress (GO:0043555)2.49549039
131ATP synthesis coupled proton transport (GO:0015986)2.49479653
132energy coupled proton transport, down electrochemical gradient (GO:0015985)2.49479653
133mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.48664908
134nonmotile primary cilium assembly (GO:0035058)2.45323764
135sulfur amino acid catabolic process (GO:0000098)2.45138374
136intraciliary transport (GO:0042073)2.44551906
137neurotransmitter-gated ion channel clustering (GO:0072578)2.43299205
138regulation of meiosis I (GO:0060631)2.42497141
139GPI anchor metabolic process (GO:0006505)2.42392185
140nephron tubule morphogenesis (GO:0072078)2.42015261
141nephron epithelium morphogenesis (GO:0072088)2.42015261
142pyrimidine nucleobase catabolic process (GO:0006208)2.41471579
143regulation of plasminogen activation (GO:0010755)2.40535465
144detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.40102668
145axoneme assembly (GO:0035082)2.38548559
146aspartate family amino acid catabolic process (GO:0009068)2.35486775
147cornea development in camera-type eye (GO:0061303)2.35471065
148protein polyglutamylation (GO:0018095)2.35458441
149lung epithelium development (GO:0060428)2.34617998
150mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.34585118
151protein-lipid complex remodeling (GO:0034368)2.33310270
152macromolecular complex remodeling (GO:0034367)2.33310270
153plasma lipoprotein particle remodeling (GO:0034369)2.33310270
154resolution of meiotic recombination intermediates (GO:0000712)2.32330761
155ubiquinone biosynthetic process (GO:0006744)2.31462699
156postsynaptic membrane organization (GO:0001941)2.30919336
157protein deneddylation (GO:0000338)2.29922479
158blood coagulation, intrinsic pathway (GO:0007597)2.29754641
159negative regulation of fibrinolysis (GO:0051918)2.27202414
160homocysteine metabolic process (GO:0050667)2.26992634
161cullin deneddylation (GO:0010388)2.25780167
162GPI anchor biosynthetic process (GO:0006506)2.24347700
163reciprocal DNA recombination (GO:0035825)2.24159240
164reciprocal meiotic recombination (GO:0007131)2.24159240
165glyoxylate metabolic process (GO:0046487)2.23753374
166cilium morphogenesis (GO:0060271)2.23383266
167very-low-density lipoprotein particle assembly (GO:0034379)2.22933170
168vitamin transmembrane transport (GO:0035461)2.21785454
169kinetochore assembly (GO:0051382)2.21387519
170ubiquinone metabolic process (GO:0006743)2.20766194
171regulation of mitochondrial translation (GO:0070129)2.20612788
172response to misfolded protein (GO:0051788)2.20403893
173glycerophospholipid catabolic process (GO:0046475)2.19120960
174alpha-amino acid catabolic process (GO:1901606)2.18781999
175male meiosis I (GO:0007141)2.18314417
176reverse cholesterol transport (GO:0043691)2.18249034
177regulation of protein activation cascade (GO:2000257)2.16664058
178low-density lipoprotein particle remodeling (GO:0034374)2.16480079
179triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.16278657
180nucleotide transmembrane transport (GO:1901679)2.15303794
181negative regulation of DNA-templated transcription, elongation (GO:0032785)2.15295311
182detection of light stimulus involved in visual perception (GO:0050908)2.15168977
183detection of light stimulus involved in sensory perception (GO:0050962)2.15168977
184artery smooth muscle contraction (GO:0014824)2.14760091

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.95790515
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.24601118
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.91083544
4ZNF274_21170338_ChIP-Seq_K562_Hela3.56215308
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.04867270
6EZH2_22144423_ChIP-Seq_EOC_Human3.01695428
7MYC_18358816_ChIP-ChIP_MESCs_Mouse3.00197547
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.84901497
9* ETS1_20019798_ChIP-Seq_JURKAT_Human2.83096541
10IGF1R_20145208_ChIP-Seq_DFB_Human2.79920598
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.79726719
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.75196624
13VDR_22108803_ChIP-Seq_LS180_Human2.73289611
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.63147134
15* EST1_17652178_ChIP-ChIP_JURKAT_Human2.63121851
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.59457481
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.49445124
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.46111176
19XRN2_22483619_ChIP-Seq_HELA_Human2.39601680
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.37314565
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.32617464
22* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.31095165
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.19921876
24E2F1_18555785_ChIP-Seq_MESCs_Mouse2.19841351
25NELFA_20434984_ChIP-Seq_ESCs_Mouse2.17695216
26ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.17090766
27FOXM1_23109430_ChIP-Seq_U2OS_Human2.14895867
28E2F4_17652178_ChIP-ChIP_JURKAT_Human2.13879656
29GABP_19822575_ChIP-Seq_HepG2_Human1.99735517
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.99397716
31ELF1_17652178_ChIP-ChIP_JURKAT_Human1.96707505
32* VDR_23849224_ChIP-Seq_CD4+_Human1.94756934
33SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.89650457
34DCP1A_22483619_ChIP-Seq_HELA_Human1.87671253
35MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.79647880
36CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.77279715
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.75196086
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.74220817
39NANOG_18555785_ChIP-Seq_MESCs_Mouse1.73967685
40FOXP3_21729870_ChIP-Seq_TREG_Human1.73329817
41TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.73075831
42ZFX_18555785_ChIP-Seq_MESCs_Mouse1.69994709
43HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.67775535
44CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.67461270
45TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.65022563
46AR_21909140_ChIP-Seq_LNCAP_Human1.64661233
47IRF1_19129219_ChIP-ChIP_H3396_Human1.63768813
48MYCN_18555785_ChIP-Seq_MESCs_Mouse1.63634299
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.62959976
50TTF2_22483619_ChIP-Seq_HELA_Human1.62347475
51POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.61342835
52SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.58587296
53* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.57674554
54* YY1_21170310_ChIP-Seq_MESCs_Mouse1.53391072
55POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.53018590
56STAT3_1855785_ChIP-Seq_MESCs_Mouse1.51952428
57SRF_21415370_ChIP-Seq_HL-1_Mouse1.49617062
58CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.49472781
59GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45700058
60RBPJ_22232070_ChIP-Seq_NCS_Mouse1.43795304
61PPARA_22158963_ChIP-Seq_LIVER_Mouse1.41787376
62CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.41063678
63* CIITA_25753668_ChIP-Seq_RAJI_Human1.40706327
64CTBP2_25329375_ChIP-Seq_LNCAP_Human1.40519320
65PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.35348133
66GBX2_23144817_ChIP-Seq_PC3_Human1.34121726
67EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.33871824
68ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.33864476
69KDM5A_27292631_Chip-Seq_BREAST_Human1.33427289
70* RXR_22158963_ChIP-Seq_LIVER_Mouse1.33417454
71PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33233308
72CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.32837956
73BMI1_23680149_ChIP-Seq_NPCS_Mouse1.32059354
74* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.31706806
75MYC_22102868_ChIP-Seq_BL_Human1.30857792
76FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.30539662
77RNF2_27304074_Chip-Seq_NSC_Mouse1.30180093
78CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.29578722
79KLF4_18555785_ChIP-Seq_MESCs_Mouse1.28787684
80* TP53_22573176_ChIP-Seq_HFKS_Human1.28564651
81PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.27005933
82CTBP1_25329375_ChIP-Seq_LNCAP_Human1.24736440
83EWS_26573619_Chip-Seq_HEK293_Human1.24665514
84CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.22751638
85KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.22461458
86DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.21566531
87CBX2_27304074_Chip-Seq_ESCs_Mouse1.21336658
88SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.21260859
89SRY_22984422_ChIP-ChIP_TESTIS_Rat1.20709443
90ERG_20887958_ChIP-Seq_HPC-7_Mouse1.20169021
91E2F1_21310950_ChIP-Seq_MCF-7_Human1.20153562
92CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.19602925
93ZNF263_19887448_ChIP-Seq_K562_Human1.18529999
94SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.18154368
95POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.17940533
96HOXB4_20404135_ChIP-ChIP_EML_Mouse1.17789062
97HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.16430178
98GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.15538408
99VDR_21846776_ChIP-Seq_THP-1_Human1.15393065
100TP63_19390658_ChIP-ChIP_HaCaT_Human1.10572028
101REST_18959480_ChIP-ChIP_MESCs_Mouse1.10051532
102TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09605943
103TFEB_21752829_ChIP-Seq_HELA_Human1.09511678
104* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.07711803
105NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.05823265
106NCOR_22424771_ChIP-Seq_293T_Human1.05724427
107* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05569069
108* ERA_21632823_ChIP-Seq_H3396_Human1.05433568
109BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.05286990
110SOX2_18692474_ChIP-Seq_MEFs_Mouse1.04183784
111E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04175246
112CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.03319926
113GATA3_21878914_ChIP-Seq_MCF-7_Human1.03119234
114OCT4_18692474_ChIP-Seq_MEFs_Mouse1.02984030
115SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.01361452
116NOTCH1_21737748_ChIP-Seq_TLL_Human1.00541086
117PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.99449150
118KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.98535550
119HOXB7_26014856_ChIP-Seq_BT474_Human0.98464124
120REST_21632747_ChIP-Seq_MESCs_Mouse0.98187222
121ZFP57_27257070_Chip-Seq_ESCs_Mouse0.97758817
122TCF3_18692474_ChIP-Seq_MEFs_Mouse0.97505854
123ELK1_22589737_ChIP-Seq_MCF10A_Human0.96618317
124E2F1_17053090_ChIP-ChIP_MCF-7_Human0.96091649
125ETV2_25802403_ChIP-Seq_MESCs_Mouse0.95510334
126AR_20517297_ChIP-Seq_VCAP_Human0.94847464
127FOXP1_21924763_ChIP-Seq_HESCs_Human0.94797106
128CTCF_18555785_ChIP-Seq_MESCs_Mouse0.92927508
129FUS_26573619_Chip-Seq_HEK293_Human0.91822974
130DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.91358432
131YY1_22570637_ChIP-Seq_MALME-3M_Human0.91193730
132TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91007800
133ELK1_19687146_ChIP-ChIP_HELA_Human0.90567100
134MYC_18940864_ChIP-ChIP_HL60_Human0.90438073
135KAP1_22055183_ChIP-Seq_ESCs_Mouse0.90367231
136PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.90058565
137SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.89672943
138SOX2_18555785_ChIP-Seq_MESCs_Mouse0.89456594
139TAF15_26573619_Chip-Seq_HEK293_Human0.88623024
140HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.88034426
141MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.87348216
142KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.86985346
143KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.86985346
144POU3F2_20337985_ChIP-ChIP_501MEL_Human0.86734807
145* FOXA1_25329375_ChIP-Seq_VCAP_Human0.86049140
146* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.86049140
147EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.85545739
148MYC_19829295_ChIP-Seq_ESCs_Human0.85119679
149FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.85072591
150EED_16625203_ChIP-ChIP_MESCs_Mouse0.84216589
151* HNF4A_19822575_ChIP-Seq_HepG2_Human0.84137093
152* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.82619569
153GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.82212980
154P300_19829295_ChIP-Seq_ESCs_Human0.81451657
155ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.81321323

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.66405886
2MP0003806_abnormal_nucleotide_metabolis4.21077111
3MP0004957_abnormal_blastocyst_morpholog3.70790947
4MP0002139_abnormal_hepatobiliary_system3.21333606
5MP0003111_abnormal_nucleus_morphology3.10516134
6MP0005360_urolithiasis3.07898549
7MP0005365_abnormal_bile_salt3.05607741
8MP0003122_maternal_imprinting2.92274758
9MP0003077_abnormal_cell_cycle2.82487121
10MP0010094_abnormal_chromosome_stability2.65341875
11MP0009840_abnormal_foam_cell2.50874750
12MP0005085_abnormal_gallbladder_physiolo2.46723191
13MP0003195_calcinosis2.42855689
14MP0008058_abnormal_DNA_repair2.42017825
15MP0001666_abnormal_nutrient_absorption2.39671034
16MP0008057_abnormal_DNA_replication2.39050803
17MP0000566_synostosis2.34180184
18MP0002938_white_spotting2.25764736
19MP0001529_abnormal_vocalization2.10733814
20MP0000490_abnormal_crypts_of2.07414111
21MP0003718_maternal_effect2.03990041
22MP0003136_yellow_coat_color2.03708221
23MP0008932_abnormal_embryonic_tissue1.98894062
24MP0008007_abnormal_cellular_replicative1.96780410
25MP0002234_abnormal_pharynx_morphology1.94080396
26MP0001730_embryonic_growth_arrest1.88825225
27MP0002876_abnormal_thyroid_physiology1.85089978
28MP0004147_increased_porphyrin_level1.83558937
29MP0008875_abnormal_xenobiotic_pharmacok1.78318534
30MP0005551_abnormal_eye_electrophysiolog1.77827659
31MP0008789_abnormal_olfactory_epithelium1.72066277
32MP0003880_abnormal_central_pattern1.70139263
33MP0003123_paternal_imprinting1.67086160
34MP0004043_abnormal_pH_regulation1.67049502
35MP0005083_abnormal_biliary_tract1.65552992
36MP0005499_abnormal_olfactory_system1.64152299
37MP0005394_taste/olfaction_phenotype1.64152299
38MP0003186_abnormal_redox_activity1.62218193
39MP0003121_genomic_imprinting1.53424351
40MP0005646_abnormal_pituitary_gland1.52025482
41MP0000350_abnormal_cell_proliferation1.49808656
42MP0002396_abnormal_hematopoietic_system1.49424151
43MP0003786_premature_aging1.47301260
44MP0010030_abnormal_orbit_morphology1.46991753
45MP0006276_abnormal_autonomic_nervous1.44792666
46MP0001984_abnormal_olfaction1.37884602
47MP0002837_dystrophic_cardiac_calcinosis1.37756596
48MP0002102_abnormal_ear_morphology1.37201300
49MP0006072_abnormal_retinal_apoptosis1.36700970
50MP0010352_gastrointestinal_tract_polyps1.35897145
51MP0005332_abnormal_amino_acid1.34834227
52MP0009379_abnormal_foot_pigmentation1.34257691
53MP0005220_abnormal_exocrine_pancreas1.33539074
54MP0005167_abnormal_blood-brain_barrier1.29177405
55MP0000778_abnormal_nervous_system1.29124060
56MP0009333_abnormal_splenocyte_physiolog1.28963210
57MP0001697_abnormal_embryo_size1.28191769
58MP0008877_abnormal_DNA_methylation1.27375649
59MP0005389_reproductive_system_phenotype1.26447806
60MP0004264_abnormal_extraembryonic_tissu1.26173248
61MP0004885_abnormal_endolymph1.25685120
62MP0003868_abnormal_feces_composition1.25084628
63MP0003937_abnormal_limbs/digits/tail_de1.24578536
64MP0004142_abnormal_muscle_tone1.24422692
65MP0002080_prenatal_lethality1.24206118
66MP0003656_abnormal_erythrocyte_physiolo1.23267471
67MP0003890_abnormal_embryonic-extraembry1.21570010
68MP0002736_abnormal_nociception_after1.19593320
69MP0000462_abnormal_digestive_system1.19122730
70MP0006036_abnormal_mitochondrial_physio1.18527428
71MP0000631_abnormal_neuroendocrine_gland1.17502669
72MP0001764_abnormal_homeostasis1.15320606
73MP0002019_abnormal_tumor_incidence1.14412926
74MP0004133_heterotaxia1.14004013
75MP0000313_abnormal_cell_death1.13230353
76MP0001672_abnormal_embryogenesis/_devel1.13172972
77MP0005380_embryogenesis_phenotype1.13172972
78MP0003315_abnormal_perineum_morphology1.13128214
79MP0000049_abnormal_middle_ear1.12792761
80MP0001968_abnormal_touch/_nociception1.12512171
81MP0002085_abnormal_embryonic_tissue1.09791059
82MP0005266_abnormal_metabolism1.09495227
83MP0008872_abnormal_physiological_respon1.08749166
84MP0002638_abnormal_pupillary_reflex1.08744494
85MP0005253_abnormal_eye_physiology1.08088767
86MP0000477_abnormal_intestine_morphology1.07350296
87MP0002653_abnormal_ependyma_morphology1.07206028
88MP0009046_muscle_twitch1.07196455
89MP0000537_abnormal_urethra_morphology1.06471966
90MP0003878_abnormal_ear_physiology1.06260026
91MP0005377_hearing/vestibular/ear_phenot1.06260026
92MP0003942_abnormal_urinary_system1.05803853
93MP0002132_abnormal_respiratory_system1.05476708
94MP0003252_abnormal_bile_duct1.05247504
95MP0003698_abnormal_male_reproductive1.04707185
96MP0002184_abnormal_innervation1.04649686
97MP0001324_abnormal_eye_pigmentation1.04136947
98MP0000609_abnormal_liver_physiology1.04027287
99MP0005195_abnormal_posterior_eye1.02591554
100MP0001873_stomach_inflammation1.01689125
101MP0002557_abnormal_social/conspecific_i1.01520171
102MP0006292_abnormal_olfactory_placode1.01367003
103MP0003011_delayed_dark_adaptation0.99949865
104MP0001145_abnormal_male_reproductive0.99248212
105MP0000358_abnormal_cell_content/0.98445227
106MP0006054_spinal_hemorrhage0.98440306
107MP0006035_abnormal_mitochondrial_morpho0.98383076
108MP0003984_embryonic_growth_retardation0.98332336
109MP0010329_abnormal_lipoprotein_level0.97971633
110MP0005319_abnormal_enzyme/_coenzyme0.97508143
111MP0002233_abnormal_nose_morphology0.96514505
112MP0005075_abnormal_melanosome_morpholog0.96288809
113MP0000647_abnormal_sebaceous_gland0.96239056
114MP0000955_abnormal_spinal_cord0.95752837
115MP0002210_abnormal_sex_determination0.95299333
116MP0001270_distended_abdomen0.95053069
117MP0002088_abnormal_embryonic_growth/wei0.94691237
118MP0002751_abnormal_autonomic_nervous0.94580030
119MP0009780_abnormal_chondrocyte_physiolo0.94577972
120MP0001293_anophthalmia0.94098912
121MP0004019_abnormal_vitamin_homeostasis0.93752882
122MP0004742_abnormal_vestibular_system0.92334340
123MP0002084_abnormal_developmental_patter0.91212100
124MP0000598_abnormal_liver_morphology0.90841383
125MP0003646_muscle_fatigue0.90606824
126MP0004924_abnormal_behavior0.89887078
127MP0005386_behavior/neurological_phenoty0.89887078
128MP0001348_abnormal_lacrimal_gland0.88943342
129MP0002272_abnormal_nervous_system0.88653120
130MP0000026_abnormal_inner_ear0.88201922
131MP0005451_abnormal_body_composition0.88117135
132MP0003567_abnormal_fetal_cardiomyocyte0.87975869
133MP0005670_abnormal_white_adipose0.87675046
134MP0003119_abnormal_digestive_system0.87489264
135MP0005084_abnormal_gallbladder_morpholo0.86533309
136MP0002752_abnormal_somatic_nervous0.86056038
137MP0001545_abnormal_hematopoietic_system0.86029525
138MP0005397_hematopoietic_system_phenotyp0.86029525
139MP0003191_abnormal_cellular_cholesterol0.85247479
140MP0000653_abnormal_sex_gland0.84872386
141MP0009745_abnormal_behavioral_response0.84636567
142MP0005408_hypopigmentation0.82413992
143MP0002086_abnormal_extraembryonic_tissu0.82402572
144MP0005391_vision/eye_phenotype0.82166596
145MP0009643_abnormal_urine_homeostasis0.81562644
146MP0001929_abnormal_gametogenesis0.81361973
147MP0008775_abnormal_heart_ventricle0.80226805
148MP0002909_abnormal_adrenal_gland0.79614714
149MP0002282_abnormal_trachea_morphology0.79508937
150MP0001286_abnormal_eye_development0.79238884
151MP0010155_abnormal_intestine_physiology0.78433776
152MP0005645_abnormal_hypothalamus_physiol0.77120692
153MP0003861_abnormal_nervous_system0.76086067
154MP0002572_abnormal_emotion/affect_behav0.75995751
155MP0002160_abnormal_reproductive_system0.75582626
156MP0002138_abnormal_hepatobiliary_system0.73105149
157MP0005023_abnormal_wound_healing0.70338626
158MP0009672_abnormal_birth_weight0.70252244
159MP0001849_ear_inflammation0.68343724
160MP0009053_abnormal_anal_canal0.67467421
161MP0001119_abnormal_female_reproductive0.66877063
162MP0005636_abnormal_mineral_homeostasis0.66833435
163MP0001853_heart_inflammation0.66321813
164MP0002089_abnormal_postnatal_growth/wei0.66081203
165MP0000613_abnormal_salivary_gland0.65918364
166MP0005376_homeostasis/metabolism_phenot0.65201490

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)4.14871045
2Reticulocytopenia (HP:0001896)4.09886825
3Abnormal number of erythroid precursors (HP:0012131)3.97563286
4Abnormality of aromatic amino acid family metabolism (HP:0004338)3.94415253
5Cerebral hypomyelination (HP:0006808)3.72407148
6Oral leukoplakia (HP:0002745)3.62884632
7Hypobetalipoproteinemia (HP:0003563)3.59436923
8Microretrognathia (HP:0000308)3.43868880
9True hermaphroditism (HP:0010459)3.39886037
10Pancreatic cysts (HP:0001737)3.39581506
11Macrocytic anemia (HP:0001972)3.31302168
12Abnormality of midbrain morphology (HP:0002418)3.29604363
13Molar tooth sign on MRI (HP:0002419)3.29604363
14Abnormality of monocarboxylic acid metabolism (HP:0010996)3.29571517
15Pancreatic fibrosis (HP:0100732)3.23673774
16Aplastic anemia (HP:0001915)3.19904573
17Abnormality of pyrimidine metabolism (HP:0004353)3.12017510
18Decreased activity of mitochondrial respiratory chain (HP:0008972)3.02479630
19Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.02479630
20Carpal bone hypoplasia (HP:0001498)2.90814908
21Rough bone trabeculation (HP:0100670)2.85090130
22Intrahepatic cholestasis (HP:0001406)2.79110178
23Breast hypoplasia (HP:0003187)2.78654416
24Hyperglycinemia (HP:0002154)2.76349789
25Multiple enchondromatosis (HP:0005701)2.76078938
26Selective tooth agenesis (HP:0001592)2.73334140
27Chronic hepatic failure (HP:0100626)2.67399964
28Retinal dysplasia (HP:0007973)2.66022320
29Type II lissencephaly (HP:0007260)2.65298155
30Medial flaring of the eyebrow (HP:0010747)2.63778237
31Progressive muscle weakness (HP:0003323)2.63360032
32Birth length less than 3rd percentile (HP:0003561)2.63277603
33Lissencephaly (HP:0001339)2.61974543
34Colon cancer (HP:0003003)2.59677241
35Cystic liver disease (HP:0006706)2.58451811
36Deep venous thrombosis (HP:0002625)2.57779904
37Pallor (HP:0000980)2.55455355
38Hyperammonemia (HP:0001987)2.54200632
39Supernumerary spleens (HP:0009799)2.52360309
40Secondary amenorrhea (HP:0000869)2.50061873
41Acute necrotizing encephalopathy (HP:0006965)2.49974706
42Hyperglycinuria (HP:0003108)2.47813423
43Increased serum lactate (HP:0002151)2.47449357
44Nephronophthisis (HP:0000090)2.47443490
45Occipital encephalocele (HP:0002085)2.45771340
46Pendular nystagmus (HP:0012043)2.45582219
47Abnormality of the renal cortex (HP:0011035)2.44094086
48Abnormality of glycine metabolism (HP:0010895)2.41172569
49Abnormality of serine family amino acid metabolism (HP:0010894)2.41172569
50Premature ovarian failure (HP:0008209)2.37394560
51Degeneration of anterior horn cells (HP:0002398)2.37358133
52Abnormality of the anterior horn cell (HP:0006802)2.37358133
53Trismus (HP:0000211)2.36022414
54Renal cortical cysts (HP:0000803)2.34655035
55Reduced antithrombin III activity (HP:0001976)2.34414197
56Sclerocornea (HP:0000647)2.33724656
57Hepatic necrosis (HP:0002605)2.33315330
58Lethargy (HP:0001254)2.32266021
59Dicarboxylic aciduria (HP:0003215)2.32152620
60Abnormality of dicarboxylic acid metabolism (HP:0010995)2.32152620
61Abnormality of DNA repair (HP:0003254)2.32144284
62Abnormality of serum amino acid levels (HP:0003112)2.31401962
63Megaloblastic anemia (HP:0001889)2.27372491
64Hepatocellular necrosis (HP:0001404)2.27281982
65Aplasia/Hypoplasia of the tibia (HP:0005772)2.27124804
66Fat malabsorption (HP:0002630)2.23952634
67Gait imbalance (HP:0002141)2.21557008
68CNS hypomyelination (HP:0003429)2.20962795
69Ragged-red muscle fibers (HP:0003200)2.20658867
70Short tibia (HP:0005736)2.15637588
71Postaxial foot polydactyly (HP:0001830)2.15493657
72Abnormality of the renal medulla (HP:0100957)2.15237908
73Abnormality of sulfur amino acid metabolism (HP:0004339)2.15237699
74Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.14680719
75Type I transferrin isoform profile (HP:0003642)2.14629299
76Congenital primary aphakia (HP:0007707)2.14464196
77Aplasia/Hypoplasia of the tongue (HP:0010295)2.13243432
78Anencephaly (HP:0002323)2.12794083
79Ependymoma (HP:0002888)2.12034377
80Increased CSF lactate (HP:0002490)2.11407884
81Irregular epiphyses (HP:0010582)2.09426875
82Abnormality of the intrinsic pathway (HP:0010989)2.09196880
83Delayed CNS myelination (HP:0002188)2.09094376
84CNS demyelination (HP:0007305)2.08602270
85Hypoplasia of the capital femoral epiphysis (HP:0003090)2.07704914
86Pancytopenia (HP:0001876)2.07534306
87Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.07310464
88Abnormality of methionine metabolism (HP:0010901)2.07210649
89Opisthotonus (HP:0002179)2.06455681
90Nephrogenic diabetes insipidus (HP:0009806)2.06317538
91Abnormality of glycolysis (HP:0004366)2.06117328
92Increased serum pyruvate (HP:0003542)2.06117328
93Patellar aplasia (HP:0006443)2.04900354
94Increased intramyocellular lipid droplets (HP:0012240)2.04239084
95Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.03153231
96Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.01683032
97Abnormal protein N-linked glycosylation (HP:0012347)2.01683032
98Abnormal protein glycosylation (HP:0012346)2.01683032
99Abnormal glycosylation (HP:0012345)2.01683032
100Male pseudohermaphroditism (HP:0000037)2.01645812
101Malnutrition (HP:0004395)2.01328892
102Generalized aminoaciduria (HP:0002909)2.01063979
103Poikiloderma (HP:0001029)2.00493622
104Increased muscle lipid content (HP:0009058)1.99050507
105Xanthomatosis (HP:0000991)1.97758604
106Aplasia/Hypoplasia of the sacrum (HP:0008517)1.97440544
107Abnormal trabecular bone morphology (HP:0100671)1.96828789
108Aplasia/Hypoplasia of the patella (HP:0006498)1.95310455
109Abnormal mitochondria in muscle tissue (HP:0008316)1.94036477
110Death in infancy (HP:0001522)1.93772582
111Abnormality of aspartate family amino acid metabolism (HP:0010899)1.93102993
112Steatorrhea (HP:0002570)1.92420154
113Emotional lability (HP:0000712)1.92262965
114Hyperlipoproteinemia (HP:0010980)1.91718592
115Lactic acidosis (HP:0003128)1.91515598
116Neoplasm of the pancreas (HP:0002894)1.91485987
117Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.91257689
118Abnormality of alanine metabolism (HP:0010916)1.91257689
119Hyperalaninemia (HP:0003348)1.91257689
120Cerebellar dysplasia (HP:0007033)1.90887414
121Progressive macrocephaly (HP:0004481)1.89319237
122Keratoconus (HP:0000563)1.89083555
123Increased corneal curvature (HP:0100692)1.89083555
124Cerebral edema (HP:0002181)1.88546599
125Acute encephalopathy (HP:0006846)1.87694946
126Progressive external ophthalmoplegia (HP:0000590)1.86228837
127Abnormal respiratory motile cilium morphology (HP:0005938)1.85658763
128Abnormal respiratory epithelium morphology (HP:0012253)1.85658763
129Preaxial hand polydactyly (HP:0001177)1.85610641
130Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.85550233
13111 pairs of ribs (HP:0000878)1.85450958
132Impulsivity (HP:0100710)1.85090587
133Hypolipoproteinemia (HP:0010981)1.84420742
134Mitochondrial inheritance (HP:0001427)1.83686613
135Pustule (HP:0200039)1.83647266
136Spastic paraparesis (HP:0002313)1.83599395
137Abolished electroretinogram (ERG) (HP:0000550)1.83404290
138Prolonged partial thromboplastin time (HP:0003645)1.83295150
139Abnormality of reticulocytes (HP:0004312)1.82327243
140Pachygyria (HP:0001302)1.82028122
141Premature graying of hair (HP:0002216)1.79452917
142Ileus (HP:0002595)1.79398834
143Abnormal cartilage morphology (HP:0002763)1.79308961
144Anophthalmia (HP:0000528)1.78811430
145Absent radius (HP:0003974)1.78615280
146Congenital stationary night blindness (HP:0007642)1.77800212
1473-Methylglutaconic aciduria (HP:0003535)1.77215939
148Decreased electroretinogram (ERG) amplitude (HP:0000654)1.76819175
149Absent epiphyses (HP:0010577)1.75310118
150Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.75310118
151Tubulointerstitial nephritis (HP:0001970)1.74617236
152Dandy-Walker malformation (HP:0001305)1.72640324
153Postaxial hand polydactyly (HP:0001162)1.70469916
154Abnormal biliary tract physiology (HP:0012439)1.70417324
155Bile duct proliferation (HP:0001408)1.70417324
156Tubular atrophy (HP:0000092)1.70186167
157Methylmalonic aciduria (HP:0012120)1.69897734
158Lipid accumulation in hepatocytes (HP:0006561)1.68761494
159Small epiphyses (HP:0010585)1.66524652
160Multicystic kidney dysplasia (HP:0000003)1.65484050
161Concave nail (HP:0001598)1.65215297
162Genital tract atresia (HP:0001827)1.65085579
163Conjugated hyperbilirubinemia (HP:0002908)1.64869017
164Congenital hepatic fibrosis (HP:0002612)1.64202802
165Horseshoe kidney (HP:0000085)1.64147347
166Epidermoid cyst (HP:0200040)1.63900187
167Aplasia/Hypoplasia of the brainstem (HP:0007362)1.62926474
168Hypoplasia of the brainstem (HP:0002365)1.62926474
169Vaginal atresia (HP:0000148)1.62552134
170Optic disc pallor (HP:0000543)1.62549493
171Abnormality of the ileum (HP:0001549)1.62307739

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.03129708
2WNK44.14223031
3WEE13.59831025
4STK163.26503367
5BMPR1B3.04580847
6NME22.96956733
7BCKDK2.88294879
8EIF2AK12.87772414
9ACVR1B2.83487225
10ZAK2.71402086
11TESK22.62520747
12FRK2.46720073
13MAP4K22.23123758
14CDC72.16607634
15PINK12.07008771
16DYRK32.06567940
17TTK1.98540148
18NEK21.92043747
19VRK11.81826197
20ADRBK21.81274965
21RPS6KA41.77909842
22MAP2K71.71498619
23EIF2AK31.71240527
24SCYL21.70091072
25STK391.70030000
26PLK41.67475412
27RPS6KB21.66312491
28GRK11.66176915
29PIK3CA1.65690781
30MAP3K111.63177370
31CDK71.62425167
32BRSK21.61714196
33MAP3K41.60058050
34TLK11.57864008
35MAP3K81.56580079
36MAPK131.56446951
37PLK11.56430830
38BCR1.53470356
39MARK11.53133163
40KDR1.52772250
41CDK81.51712174
42PIM21.49350104
43FLT31.40736171
44MAP2K21.39962156
45ERN11.39437942
46EPHA21.38948974
47PAK41.38926371
48MAPKAPK31.38329678
49CASK1.34742934
50VRK21.34402204
51AURKB1.29170643
52AURKA1.28089419
53NUAK11.27072035
54TIE11.25883328
55CSNK1A1L1.24033170
56WNK31.23433816
57NTRK31.21585017
58PBK1.21237637
59EPHA41.19602446
60STK38L1.16293298
61TRIM281.14369782
62NEK11.13447094
63PASK1.12608491
64TSSK61.10211932
65BRAF1.08669617
66ATR1.02252487
67SRPK10.99938473
68EEF2K0.99586531
69NTRK20.99283696
70CAMKK20.98037052
71ARAF0.97055382
72PRKCG0.95441416
73CHEK20.95390930
74LATS20.94984346
75PNCK0.93532433
76CSNK1G20.93507533
77IRAK30.93210740
78DYRK20.92782824
79PRKCI0.92528159
80TGFBR10.92165958
81PAK10.91129416
82CDK190.90672383
83BRSK10.88924297
84INSRR0.87644010
85PLK20.84326540
86LRRK20.83494465
87STK100.83369031
88CDK40.82016328
89MAPK150.80661212
90MAP3K100.78112028
91MAP4K10.77839148
92TESK10.76031333
93TAOK30.74698993
94EPHB20.73527930
95TYRO30.73062028
96CDK120.72002451
97PRKD30.70583329
98OXSR10.69191955
99SIK20.68678032
100CHEK10.68208760
101MKNK10.67499279
102LATS10.66757251
103PIM10.65267731
104TAOK20.63404937
105ADRBK10.62573024
106CSNK1A10.62200311
107STK30.61900019
108MINK10.61822211
109CSNK1G30.61366002
110TAOK10.60317578
111RAF10.59501819
112ABL20.58007272
113AKT20.56064752
114DAPK20.54556974
115TXK0.54083857
116CSNK2A20.53219954
117CSNK2A10.52767231
118MAP2K60.52622159
119CDK20.50352620
120WNK10.48498683
121PLK30.47197360
122RPS6KA50.46590954
123MAPKAPK50.46312644
124PRKG20.45483411
125MAPK110.44320603
126MET0.43336861
127PKN20.43113803
128ICK0.43041441
129BTK0.42681318
130FGFR20.42669712
131MTOR0.42647452
132CAMK10.42428828
133LIMK10.40842567
134PHKG10.40443536
135PHKG20.40443536
136PRKAA20.39432786
137PRKAA10.39319925
138PRKCE0.39147142
139CSNK1E0.38386718
140DYRK1B0.37994373
141MAP2K40.37894794
142PRKACA0.37709739
143CSNK1G10.36873434
144ERBB40.36239411
145CCNB10.35968956
146MUSK0.35239132
147MATK0.35114375
148ATM0.35065006
149GRK60.33906763
150PAK20.33226338
151CDK10.29129038
152JAK30.28863811
153MST1R0.28816630
154MAP2K30.28568559
155CDK11A0.27968947
156KSR20.27825356
157NME10.27222245
158ZAP700.26218293

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.57065616
2Ribosome_Homo sapiens_hsa030103.44148638
3Mismatch repair_Homo sapiens_hsa034302.91963383
4RNA polymerase_Homo sapiens_hsa030202.79932637
5Folate biosynthesis_Homo sapiens_hsa007902.73660716
6Proteasome_Homo sapiens_hsa030502.67066642
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.55725246
8Pyrimidine metabolism_Homo sapiens_hsa002402.36647759
9Spliceosome_Homo sapiens_hsa030402.24486725
10Base excision repair_Homo sapiens_hsa034102.16635691
11One carbon pool by folate_Homo sapiens_hsa006702.14147198
12RNA transport_Homo sapiens_hsa030132.01341211
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.00669684
14Homologous recombination_Homo sapiens_hsa034401.99657632
15Nucleotide excision repair_Homo sapiens_hsa034201.91579633
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.90455905
17Sulfur relay system_Homo sapiens_hsa041221.81032680
18Selenocompound metabolism_Homo sapiens_hsa004501.74881850
19Cysteine and methionine metabolism_Homo sapiens_hsa002701.72572094
20Drug metabolism - other enzymes_Homo sapiens_hsa009831.69595452
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.66030573
22Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.58922650
23Biosynthesis of amino acids_Homo sapiens_hsa012301.56359921
24Pentose phosphate pathway_Homo sapiens_hsa000301.53810317
25Phototransduction_Homo sapiens_hsa047441.50153838
26Cyanoamino acid metabolism_Homo sapiens_hsa004601.48346216
27Fat digestion and absorption_Homo sapiens_hsa049751.45601392
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.43555386
29Primary bile acid biosynthesis_Homo sapiens_hsa001201.43216024
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.41946023
31Cell cycle_Homo sapiens_hsa041101.41854495
32Complement and coagulation cascades_Homo sapiens_hsa046101.36228031
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.30871252
34Glutathione metabolism_Homo sapiens_hsa004801.23653888
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.23637294
36Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.21714464
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.16899612
38Vitamin B6 metabolism_Homo sapiens_hsa007501.15611798
39Purine metabolism_Homo sapiens_hsa002301.13057381
40Protein export_Homo sapiens_hsa030601.10250629
41Carbon metabolism_Homo sapiens_hsa012001.10012549
42Arginine and proline metabolism_Homo sapiens_hsa003301.06576254
43Basal transcription factors_Homo sapiens_hsa030221.03305790
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.03076082
45RNA degradation_Homo sapiens_hsa030181.02231648
46Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.01220083
47Histidine metabolism_Homo sapiens_hsa003401.00164053
48Maturity onset diabetes of the young_Homo sapiens_hsa049500.97664506
49Nicotine addiction_Homo sapiens_hsa050330.97534831
50Tryptophan metabolism_Homo sapiens_hsa003800.95354020
51Alzheimers disease_Homo sapiens_hsa050100.94722817
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94108452
53p53 signaling pathway_Homo sapiens_hsa041150.93062502
54Fanconi anemia pathway_Homo sapiens_hsa034600.92472383
55Pentose and glucuronate interconversions_Homo sapiens_hsa000400.91152973
56Fructose and mannose metabolism_Homo sapiens_hsa000510.91116279
57Sulfur metabolism_Homo sapiens_hsa009200.90383477
58Vitamin digestion and absorption_Homo sapiens_hsa049770.90045943
59ABC transporters_Homo sapiens_hsa020100.89789360
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.88583554
61Parkinsons disease_Homo sapiens_hsa050120.88563454
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.88354248
63Peroxisome_Homo sapiens_hsa041460.87082449
64Fatty acid biosynthesis_Homo sapiens_hsa000610.86871243
65Fatty acid degradation_Homo sapiens_hsa000710.85800671
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84999621
67Chemical carcinogenesis_Homo sapiens_hsa052040.84953116
68Pyruvate metabolism_Homo sapiens_hsa006200.83347685
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.82755341
70Arginine biosynthesis_Homo sapiens_hsa002200.77445088
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.76535690
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.76391820
73Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.75820056
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75732211
75Cardiac muscle contraction_Homo sapiens_hsa042600.73761690
76Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.72969760
77Metabolic pathways_Homo sapiens_hsa011000.72457690
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71047109
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70918170
80Nitrogen metabolism_Homo sapiens_hsa009100.70269191
81Retinol metabolism_Homo sapiens_hsa008300.69810608
82Non-homologous end-joining_Homo sapiens_hsa034500.68499601
83Huntingtons disease_Homo sapiens_hsa050160.67429912
84Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67168668
85Oxidative phosphorylation_Homo sapiens_hsa001900.66174383
86Butanoate metabolism_Homo sapiens_hsa006500.66114131
87PPAR signaling pathway_Homo sapiens_hsa033200.65306311
88Galactose metabolism_Homo sapiens_hsa000520.62617416
89Linoleic acid metabolism_Homo sapiens_hsa005910.61970553
90beta-Alanine metabolism_Homo sapiens_hsa004100.60369161
91Steroid biosynthesis_Homo sapiens_hsa001000.59538220
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58915745
93Fatty acid elongation_Homo sapiens_hsa000620.58426579
94Propanoate metabolism_Homo sapiens_hsa006400.58231583
95Caffeine metabolism_Homo sapiens_hsa002320.58125804
96mRNA surveillance pathway_Homo sapiens_hsa030150.57471695
97GABAergic synapse_Homo sapiens_hsa047270.56057875
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55272519
99Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53919454
100Epstein-Barr virus infection_Homo sapiens_hsa051690.53547764
101Steroid hormone biosynthesis_Homo sapiens_hsa001400.52503051
102Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51472739
103Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51350942
104Tyrosine metabolism_Homo sapiens_hsa003500.49793308
105Basal cell carcinoma_Homo sapiens_hsa052170.48273930
106Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48141203
107N-Glycan biosynthesis_Homo sapiens_hsa005100.46776672
108Phenylalanine metabolism_Homo sapiens_hsa003600.45398154
109Ether lipid metabolism_Homo sapiens_hsa005650.45221741
110Lysine degradation_Homo sapiens_hsa003100.44845853
111Thyroid cancer_Homo sapiens_hsa052160.43397392
112Regulation of autophagy_Homo sapiens_hsa041400.37475553
113Fatty acid metabolism_Homo sapiens_hsa012120.35941968
114Renin-angiotensin system_Homo sapiens_hsa046140.35417683
115Glycerolipid metabolism_Homo sapiens_hsa005610.34732271
116Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33711663
117Starch and sucrose metabolism_Homo sapiens_hsa005000.33214861
118Herpes simplex infection_Homo sapiens_hsa051680.32078367

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