PRPSAP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that associates with the enzyme phosphoribosylpyrophosphate synthetase (PRS). PRS catalyzes the formation of phosphoribosylpyrophosphate which is a substrate for synthesis of purine and pyrimidine nucleotides, histidine, tryptophan and NAD. PRS exists as a complex with two catalytic subunits and two associated subunits. This gene encodes a non-catalytic associated subunit of PRS. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)5.27918849
2ribosome assembly (GO:0042255)4.73324218
3pyrimidine nucleobase catabolic process (GO:0006208)4.51484548
4purine nucleobase biosynthetic process (GO:0009113)4.42936919
5DNA replication checkpoint (GO:0000076)4.37261473
6metaphase plate congression (GO:0051310)4.37033214
7nucleobase biosynthetic process (GO:0046112)4.33335452
8regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.28420647
9formation of translation preinitiation complex (GO:0001731)4.20810540
10protein localization to kinetochore (GO:0034501)4.14188676
11ribosome biogenesis (GO:0042254)4.10568977
12regulation of spindle organization (GO:0090224)3.86398798
13attachment of spindle microtubules to kinetochore (GO:0008608)3.83621913
14CENP-A containing nucleosome assembly (GO:0034080)3.83577834
15DNA replication initiation (GO:0006270)3.80421363
16establishment of chromosome localization (GO:0051303)3.79112699
17positive regulation of chromosome segregation (GO:0051984)3.76883168
18chromatin remodeling at centromere (GO:0031055)3.75323593
19DNA strand elongation involved in DNA replication (GO:0006271)3.68886574
20mitotic nuclear envelope disassembly (GO:0007077)3.68758298
21DNA replication-independent nucleosome organization (GO:0034724)3.67910388
22DNA replication-independent nucleosome assembly (GO:0006336)3.67910388
23negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.60990895
24establishment of protein localization to mitochondrial membrane (GO:0090151)3.60151554
25spindle checkpoint (GO:0031577)3.60057643
26negative regulation of chromosome segregation (GO:0051985)3.58326628
27regulation of chromosome segregation (GO:0051983)3.56022819
28negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.54645406
29negative regulation of sister chromatid segregation (GO:0033046)3.54645406
30negative regulation of mitotic sister chromatid separation (GO:2000816)3.54645406
31negative regulation of mitotic sister chromatid segregation (GO:0033048)3.54645406
32mitotic spindle checkpoint (GO:0071174)3.52939993
33mitotic spindle assembly checkpoint (GO:0007094)3.52229521
34DNA replication-dependent nucleosome organization (GO:0034723)3.52177028
35DNA replication-dependent nucleosome assembly (GO:0006335)3.52177028
36proteasome assembly (GO:0043248)3.51821434
37DNA strand elongation (GO:0022616)3.51618837
38protein localization to chromosome, centromeric region (GO:0071459)3.50418604
39mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.49511851
40rRNA modification (GO:0000154)3.48645558
41nuclear pore organization (GO:0006999)3.47204143
42protein K6-linked ubiquitination (GO:0085020)3.47024011
43nucleobase catabolic process (GO:0046113)3.46810999
44nuclear envelope disassembly (GO:0051081)3.46709185
45membrane disassembly (GO:0030397)3.46709185
46DNA damage response, detection of DNA damage (GO:0042769)3.44695043
47anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.44338960
48spindle assembly checkpoint (GO:0071173)3.43783664
49histone exchange (GO:0043486)3.42069458
50regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.40875048
51regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.38914146
52histone H2A monoubiquitination (GO:0035518)3.38439794
53transcription elongation from RNA polymerase III promoter (GO:0006385)3.35454934
54termination of RNA polymerase III transcription (GO:0006386)3.35454934
55regulation of mitotic metaphase/anaphase transition (GO:0030071)3.33530939
56cullin deneddylation (GO:0010388)3.30389595
577-methylguanosine mRNA capping (GO:0006370)3.30251968
58regulation of nuclear cell cycle DNA replication (GO:0033262)3.29882294
59protein neddylation (GO:0045116)3.29197732
60regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.28653580
61DNA unwinding involved in DNA replication (GO:0006268)3.28570832
62respiratory chain complex IV assembly (GO:0008535)3.28347211
63positive regulation of mitochondrial fission (GO:0090141)3.27203681
64ribonucleoprotein complex biogenesis (GO:0022613)3.27005223
65maturation of 5.8S rRNA (GO:0000460)3.26827345
66folic acid metabolic process (GO:0046655)3.25415466
67positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.23960136
68negative regulation of histone methylation (GO:0031061)3.22037137
69maturation of SSU-rRNA (GO:0030490)3.21733363
70ATP synthesis coupled proton transport (GO:0015986)3.21175350
71energy coupled proton transport, down electrochemical gradient (GO:0015985)3.21175350
72histone H2A acetylation (GO:0043968)3.21101118
73regulation of sister chromatid segregation (GO:0033045)3.20601173
74regulation of mitotic sister chromatid separation (GO:0010965)3.20601173
75regulation of mitotic sister chromatid segregation (GO:0033047)3.20601173
76establishment of mitochondrion localization (GO:0051654)3.20204452
77spliceosomal snRNP assembly (GO:0000387)3.19204247
78RNA capping (GO:0036260)3.18514305
797-methylguanosine RNA capping (GO:0009452)3.18514305
80sequestering of actin monomers (GO:0042989)3.18173789
81telomere maintenance via semi-conservative replication (GO:0032201)3.18022060
82negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.17945999
83mitotic sister chromatid segregation (GO:0000070)3.17372543
84protein complex biogenesis (GO:0070271)3.16514030
85regulation of sister chromatid cohesion (GO:0007063)3.15850530
86transcription-coupled nucleotide-excision repair (GO:0006283)3.14436887
87protein localization to chromosome (GO:0034502)3.13901831
88somatic hypermutation of immunoglobulin genes (GO:0016446)3.11141049
89somatic diversification of immune receptors via somatic mutation (GO:0002566)3.11141049
90rRNA processing (GO:0006364)3.11052557
91ribosomal small subunit assembly (GO:0000028)3.10626883
92transcription elongation from RNA polymerase I promoter (GO:0006362)3.08723971
93mitotic chromosome condensation (GO:0007076)3.06238645
94behavioral response to nicotine (GO:0035095)3.05823738
95tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.05431756
96RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.05431756
97mitochondrial respiratory chain complex assembly (GO:0033108)3.04674864
98pseudouridine synthesis (GO:0001522)3.04210888
99termination of RNA polymerase I transcription (GO:0006363)3.04049418
100negative regulation of DNA-templated transcription, elongation (GO:0032785)3.03427194
101negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.03427194
102regulation of translation in response to stress (GO:0043555)3.02616626
103rRNA metabolic process (GO:0016072)3.02067429
104positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.01183645
105protein deneddylation (GO:0000338)3.01034843
106regulation of helicase activity (GO:0051095)2.99995538
107regulation of mitotic spindle organization (GO:0060236)2.99274010
108ribosomal large subunit biogenesis (GO:0042273)2.98939272
109ubiquinone metabolic process (GO:0006743)2.97898649
110mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.97729641
111mitochondrial respiratory chain complex I assembly (GO:0032981)2.97729641
112NADH dehydrogenase complex assembly (GO:0010257)2.97729641
113protein-cofactor linkage (GO:0018065)2.97123633
114telomere maintenance via recombination (GO:0000722)2.93808369
115nuclear envelope organization (GO:0006998)2.93687620
116transcription elongation from RNA polymerase II promoter (GO:0006368)2.93673411
117chromatin assembly or disassembly (GO:0006333)2.93595444
118regulation of centrosome cycle (GO:0046605)2.93308560
119cytochrome complex assembly (GO:0017004)2.92260031
120DNA-templated transcription, elongation (GO:0006354)2.92065438
121regulation of histone H3-K27 methylation (GO:0061085)2.91562838
122chaperone-mediated protein transport (GO:0072321)2.91313380
123histone H2A ubiquitination (GO:0033522)2.91167364
124regulation of double-strand break repair via homologous recombination (GO:0010569)2.91057893
125response to pheromone (GO:0019236)2.90582104
126nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.89456002
127regulation of exit from mitosis (GO:0007096)2.89396875
128exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.88732892
129RNA splicing, via transesterification reactions (GO:0000375)2.88665931
130DNA-dependent DNA replication (GO:0006261)2.88427994
131intraciliary transport (GO:0042073)2.85685249
132neural tube formation (GO:0001841)2.80206054
133regulation of mitochondrial translation (GO:0070129)2.75109979
134regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.65108495
135regulation of mitotic spindle checkpoint (GO:1903504)2.65108495
136ubiquinone biosynthetic process (GO:0006744)2.64940385
137mitochondrion transport along microtubule (GO:0047497)2.64009307
138establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.64009307
139forebrain neuron differentiation (GO:0021879)2.61279566
140regulation of cilium movement (GO:0003352)2.60598269
141DNA double-strand break processing (GO:0000729)2.60138068
142mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.57601078
143translational termination (GO:0006415)2.57384895
144organelle disassembly (GO:1903008)2.54739443
145nonmotile primary cilium assembly (GO:0035058)2.54702168
146base-excision repair, AP site formation (GO:0006285)2.54237815
147neuron cell-cell adhesion (GO:0007158)2.51764196
148viral transcription (GO:0019083)2.50365661
149water-soluble vitamin biosynthetic process (GO:0042364)2.49835338
150retinal ganglion cell axon guidance (GO:0031290)2.46934753
151pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.45832671
152protein polyglutamylation (GO:0018095)2.44776413
153de novo posttranslational protein folding (GO:0051084)2.44023018
154ribonucleoprotein complex disassembly (GO:0032988)2.43754981
155metallo-sulfur cluster assembly (GO:0031163)2.41804387
156iron-sulfur cluster assembly (GO:0016226)2.41804387
157resolution of meiotic recombination intermediates (GO:0000712)2.41755303
158respiratory electron transport chain (GO:0022904)2.40894498
159regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.40782949
160cotranslational protein targeting to membrane (GO:0006613)2.40253279
161protein localization to cilium (GO:0061512)2.39879992
162negative regulation of DNA recombination (GO:0045910)2.39651238
163gamma-aminobutyric acid transport (GO:0015812)2.39318453
164synapsis (GO:0007129)2.39072242
165establishment of protein localization to mitochondrion (GO:0072655)2.38605272
166SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.37828045
167electron transport chain (GO:0022900)2.36923525
168de novo protein folding (GO:0006458)2.36563918
169isoprenoid biosynthetic process (GO:0008299)2.36254120
170DNA deamination (GO:0045006)2.35524174
171spliceosomal complex assembly (GO:0000245)2.33998935
172tRNA aminoacylation for protein translation (GO:0006418)2.32453881
173protein localization to mitochondrion (GO:0070585)2.32235836
174negative regulation of transcription regulatory region DNA binding (GO:2000678)2.31386603
175peptidyl-arginine N-methylation (GO:0035246)2.31160204
176peptidyl-arginine methylation (GO:0018216)2.31160204
177somite development (GO:0061053)2.30367432
178translational elongation (GO:0006414)2.30095912
179protein targeting to ER (GO:0045047)2.29988227
180cellular component biogenesis (GO:0044085)2.29876234
181cholesterol biosynthetic process (GO:0006695)2.29460826
182tRNA processing (GO:0008033)2.28716315
183tRNA metabolic process (GO:0006399)2.28699559
184single strand break repair (GO:0000012)2.28617922
185spinal cord association neuron differentiation (GO:0021527)2.28433970
186tRNA aminoacylation (GO:0043039)2.28064841
187amino acid activation (GO:0043038)2.28064841
188translation (GO:0006412)2.28017114

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.12075558
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.10457991
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.03968312
4FOXM1_23109430_ChIP-Seq_U2OS_Human4.00934300
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.24449245
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.09336289
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.08262275
8MYC_19079543_ChIP-ChIP_MESCs_Mouse3.02752411
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.00034031
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.96016143
11ZNF274_21170338_ChIP-Seq_K562_Hela2.87841936
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.87827594
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.87203370
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.83172639
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.78948123
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.75889570
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.75604543
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.72290678
19EZH2_22144423_ChIP-Seq_EOC_Human2.67825642
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.49831910
21VDR_23849224_ChIP-Seq_CD4+_Human2.45513934
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.44896409
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.36885551
24IGF1R_20145208_ChIP-Seq_DFB_Human2.30037992
25XRN2_22483619_ChIP-Seq_HELA_Human2.28214898
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.21026961
27AR_21909140_ChIP-Seq_LNCAP_Human2.17069289
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.16493635
29* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.15633027
30HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.14273293
31MYCN_18555785_ChIP-Seq_MESCs_Mouse2.09806528
32POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.08631678
33GABP_19822575_ChIP-Seq_HepG2_Human2.07864050
34THAP11_20581084_ChIP-Seq_MESCs_Mouse2.05708081
35FOXP3_21729870_ChIP-Seq_TREG_Human1.98721642
36* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.96798957
37TAF15_26573619_Chip-Seq_HEK293_Human1.95484987
38FUS_26573619_Chip-Seq_HEK293_Human1.92977630
39DCP1A_22483619_ChIP-Seq_HELA_Human1.91775889
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.91300599
41MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.90624864
42YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.89978189
43EGR1_19374776_ChIP-ChIP_THP-1_Human1.88972882
44IRF1_19129219_ChIP-ChIP_H3396_Human1.88827547
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88490288
46KDM5A_27292631_Chip-Seq_BREAST_Human1.86702142
47CIITA_25753668_ChIP-Seq_RAJI_Human1.84757594
48NANOG_18555785_ChIP-Seq_MESCs_Mouse1.83998320
49EWS_26573619_Chip-Seq_HEK293_Human1.81790877
50TTF2_22483619_ChIP-Seq_HELA_Human1.79229885
51E2F1_21310950_ChIP-Seq_MCF-7_Human1.72626500
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.71836858
53* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.70674973
54SALL1_21062744_ChIP-ChIP_HESCs_Human1.69096250
55MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.67177622
56POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65887036
57POU5F1_16153702_ChIP-ChIP_HESCs_Human1.64533188
58ZFX_18555785_ChIP-Seq_MESCs_Mouse1.64462849
59ZFP57_27257070_Chip-Seq_ESCs_Mouse1.63200155
60CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.61567501
61MYC_22102868_ChIP-Seq_BL_Human1.60995964
62POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.58317544
63SOX2_16153702_ChIP-ChIP_HESCs_Human1.55552081
64RNF2_27304074_Chip-Seq_NSC_Mouse1.51960591
65SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.50412185
66CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.50347132
67GBX2_23144817_ChIP-Seq_PC3_Human1.49785119
68ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.46110938
69TP63_19390658_ChIP-ChIP_HaCaT_Human1.42814280
70CBX2_27304074_Chip-Seq_ESCs_Mouse1.41355624
71* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40871506
72VDR_22108803_ChIP-Seq_LS180_Human1.40618978
73CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.39424617
74BMI1_23680149_ChIP-Seq_NPCS_Mouse1.38233001
75KLF4_18555785_ChIP-Seq_MESCs_Mouse1.37204405
76ELF1_17652178_ChIP-ChIP_JURKAT_Human1.37171412
77FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.35865844
78CTBP2_25329375_ChIP-Seq_LNCAP_Human1.34158021
79FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.33815181
80TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33763036
81HOXB4_20404135_ChIP-ChIP_EML_Mouse1.33542380
82GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.32963363
83SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.32955922
84NANOG_21062744_ChIP-ChIP_HESCs_Human1.31178187
85SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.27887571
86CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25291715
87SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.24084247
88ELK1_19687146_ChIP-ChIP_HELA_Human1.24081679
89NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.23469508
90PADI4_21655091_ChIP-ChIP_MCF-7_Human1.23446863
91FLI1_27457419_Chip-Seq_LIVER_Mouse1.23066806
92DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.22819818
93P300_19829295_ChIP-Seq_ESCs_Human1.22099418
94E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19462497
95ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.18778228
96REST_21632747_ChIP-Seq_MESCs_Mouse1.18665997
97TP53_22573176_ChIP-Seq_HFKS_Human1.17989649
98POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.17771678
99NOTCH1_21737748_ChIP-Seq_TLL_Human1.17725259
100MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16908695
101SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.16498947
102CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.15175410
103NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.14316657
104REST_18959480_ChIP-ChIP_MESCs_Mouse1.13968414
105SRF_21415370_ChIP-Seq_HL-1_Mouse1.13884239
106CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.13061803
107TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.13058599
108* TFEB_21752829_ChIP-Seq_HELA_Human1.11081238
109ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.10785627
110PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.09617067
111SOX2_18555785_ChIP-Seq_MESCs_Mouse1.06505387
112SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.06421847
113ERG_20887958_ChIP-Seq_HPC-7_Mouse1.05378231
114EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04320580
115BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03708530
116GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02135944
117KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.00660812
118CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00560388
119NANOG_16153702_ChIP-ChIP_HESCs_Human1.00117917
120STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99190048
121RBPJ_22232070_ChIP-Seq_NCS_Mouse0.99008089
122GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98043017
123ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97316813
124FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.96966287
125SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.96383799
126KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96317328
127TCF3_18692474_ChIP-Seq_MEFs_Mouse0.94217572
128MYC_18940864_ChIP-ChIP_HL60_Human0.92099771
129PCGF2_27294783_Chip-Seq_ESCs_Mouse0.90693850
130TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.88961647
131CBP_20019798_ChIP-Seq_JUKART_Human0.88626320
132IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.88626320
133PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.88191438
134NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.87354154
135TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.86140475
136KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.84903764
137KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.84903764
138KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.84903764
139ZNF263_19887448_ChIP-Seq_K562_Human0.84671169
140SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.83042910
141UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.81912507
142TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.81027126

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.08657791
2MP0003111_abnormal_nucleus_morphology4.81177315
3MP0004957_abnormal_blastocyst_morpholog4.53254291
4MP0010094_abnormal_chromosome_stability4.51326791
5MP0003077_abnormal_cell_cycle4.05681127
6MP0008058_abnormal_DNA_repair3.54413568
7MP0008057_abnormal_DNA_replication3.09548468
8MP0003718_maternal_effect3.06501482
9MP0008877_abnormal_DNA_methylation3.03555591
10MP0003123_paternal_imprinting2.90774712
11MP0002653_abnormal_ependyma_morphology2.80029731
12MP0008932_abnormal_embryonic_tissue2.76421796
13MP0008260_abnormal_autophagy2.65051940
14MP0003880_abnormal_central_pattern2.62419329
15MP0001730_embryonic_growth_arrest2.59160272
16MP0008007_abnormal_cellular_replicative2.55490892
17MP0003122_maternal_imprinting2.51300413
18MP0000350_abnormal_cell_proliferation2.30556687
19MP0003786_premature_aging2.13536317
20MP0005645_abnormal_hypothalamus_physiol2.09443486
21MP0006292_abnormal_olfactory_placode1.92371766
22MP0000778_abnormal_nervous_system1.91670160
23MP0001984_abnormal_olfaction1.89825515
24MP0002396_abnormal_hematopoietic_system1.88809920
25MP0001672_abnormal_embryogenesis/_devel1.83576594
26MP0005380_embryogenesis_phenotype1.83576594
27MP0003121_genomic_imprinting1.82607942
28MP0001697_abnormal_embryo_size1.82121899
29MP0002210_abnormal_sex_determination1.79066870
30MP0001188_hyperpigmentation1.78876550
31MP0002822_catalepsy1.77816349
32MP0002163_abnormal_gland_morphology1.75587317
33MP0006276_abnormal_autonomic_nervous1.71200414
34MP0002085_abnormal_embryonic_tissue1.66131542
35MP0010307_abnormal_tumor_latency1.61894974
36MP0002736_abnormal_nociception_after1.61068425
37MP0002080_prenatal_lethality1.59757559
38MP0000372_irregular_coat_pigmentation1.58484897
39MP0003984_embryonic_growth_retardation1.57981872
40MP0002084_abnormal_developmental_patter1.57475363
41MP0009046_muscle_twitch1.57013913
42MP0002088_abnormal_embryonic_growth/wei1.52964372
43MP0001929_abnormal_gametogenesis1.52800959
44MP0001145_abnormal_male_reproductive1.52282428
45MP0000631_abnormal_neuroendocrine_gland1.50586914
46MP0005423_abnormal_somatic_nervous1.48640940
47MP0004142_abnormal_muscle_tone1.48295697
48MP0000653_abnormal_sex_gland1.44649265
49MP0003890_abnormal_embryonic-extraembry1.43295150
50MP0002837_dystrophic_cardiac_calcinosis1.42967781
51MP0000313_abnormal_cell_death1.37142653
52MP0001968_abnormal_touch/_nociception1.35795818
53MP0002272_abnormal_nervous_system1.34274118
54MP0009333_abnormal_splenocyte_physiolog1.32707767
55MP0004147_increased_porphyrin_level1.32508062
56MP0005551_abnormal_eye_electrophysiolog1.30791312
57MP0009745_abnormal_behavioral_response1.29602354
58MP0000955_abnormal_spinal_cord1.27028589
59MP0002019_abnormal_tumor_incidence1.24017577
60MP0003635_abnormal_synaptic_transmissio1.23512958
61MP0002086_abnormal_extraembryonic_tissu1.22957568
62MP0003315_abnormal_perineum_morphology1.22834991
63MP0004859_abnormal_synaptic_plasticity1.21967406
64MP0002938_white_spotting1.21056559
65MP0003567_abnormal_fetal_cardiomyocyte1.20827882
66MP0004133_heterotaxia1.20623153
67MP0005379_endocrine/exocrine_gland_phen1.19992545
68MP0002557_abnormal_social/conspecific_i1.19401006
69MP0003646_muscle_fatigue1.18163736
70MP0002184_abnormal_innervation1.16345259
71MP0003119_abnormal_digestive_system1.14621342
72MP0001119_abnormal_female_reproductive1.14503252
73MP0002735_abnormal_chemical_nociception1.14322439
74MP0006072_abnormal_retinal_apoptosis1.13808757
75MP0002063_abnormal_learning/memory/cond1.13783739
76MP0000049_abnormal_middle_ear1.13011624
77MP0000490_abnormal_crypts_of1.11916613
78MP0002572_abnormal_emotion/affect_behav1.11335417
79MP0004924_abnormal_behavior1.10198667
80MP0005386_behavior/neurological_phenoty1.10198667
81MP0004811_abnormal_neuron_physiology1.09968619
82MP0009840_abnormal_foam_cell1.08973706
83MP0004197_abnormal_fetal_growth/weight/1.08248450
84MP0000537_abnormal_urethra_morphology1.07055196
85MP0005646_abnormal_pituitary_gland1.06655708
86MP0006035_abnormal_mitochondrial_morpho1.06138913
87MP0002752_abnormal_somatic_nervous1.05824597
88MP0000569_abnormal_digit_pigmentation1.05043756
89MP0002102_abnormal_ear_morphology1.04831412
90MP0002067_abnormal_sensory_capabilities1.04695601
91MP0004808_abnormal_hematopoietic_stem1.03829216
92MP0002233_abnormal_nose_morphology1.03681368
93MP0003221_abnormal_cardiomyocyte_apopto1.02707689
94MP0001293_anophthalmia1.00909023
95MP0002882_abnormal_neuron_morphology0.99749737
96MP0002234_abnormal_pharynx_morphology0.99622696
97MP0001486_abnormal_startle_reflex0.98847715
98MP0003699_abnormal_female_reproductive0.97944124
99MP0001764_abnormal_homeostasis0.95917811
100MP0004270_analgesia0.95184510
101MP0000358_abnormal_cell_content/0.94588507
102MP0002064_seizures0.92502158
103MP0009672_abnormal_birth_weight0.92158080
104MP0005195_abnormal_posterior_eye0.90479285
105MP0002161_abnormal_fertility/fecundity0.90132148
106MP0002734_abnormal_mechanical_nocicepti0.90065409
107MP0005395_other_phenotype0.89187659
108MP0005384_cellular_phenotype0.89167517
109MP0002160_abnormal_reproductive_system0.86459447
110MP0000703_abnormal_thymus_morphology0.86086224
111MP0002152_abnormal_brain_morphology0.85582750
112MP0005389_reproductive_system_phenotype0.85014449
113MP0001986_abnormal_taste_sensitivity0.84872149
114MP0000428_abnormal_craniofacial_morphol0.83364499
115MP0001346_abnormal_lacrimal_gland0.82669625
116MP0005621_abnormal_cell_physiology0.81998668
117MP0008872_abnormal_physiological_respon0.81976456
118MP0010352_gastrointestinal_tract_polyps0.81668413
119MP0003698_abnormal_male_reproductive0.81623273
120MP0004742_abnormal_vestibular_system0.80415100
121MP0003861_abnormal_nervous_system0.78625830
122MP0003763_abnormal_thymus_physiology0.77445957
123MP0003136_yellow_coat_color0.77252242
124MP0008789_abnormal_olfactory_epithelium0.76252530
125MP0002398_abnormal_bone_marrow0.75993579
126MP0001529_abnormal_vocalization0.74400956
127MP0009703_decreased_birth_body0.72386176
128MP0002722_abnormal_immune_system0.71404399
129MP0005397_hematopoietic_system_phenotyp0.71289924
130MP0001545_abnormal_hematopoietic_system0.71289924
131MP0000689_abnormal_spleen_morphology0.71086679
132MP0008995_early_reproductive_senescence0.70837283
133MP0005310_abnormal_salivary_gland0.69817761
134MP0005391_vision/eye_phenotype0.67582675
135MP0001919_abnormal_reproductive_system0.66866840
136MP0000465_gastrointestinal_hemorrhage0.66682055
137MP0002092_abnormal_eye_morphology0.66655971
138MP0001286_abnormal_eye_development0.65222161
139MP0003938_abnormal_ear_development0.62286744
140MP0002751_abnormal_autonomic_nervous0.59947503
141MP0005499_abnormal_olfactory_system0.59876873
142MP0005394_taste/olfaction_phenotype0.59876873
143MP0005075_abnormal_melanosome_morpholog0.59382614
144MP0003806_abnormal_nucleotide_metabolis0.56681164
145MP0003937_abnormal_limbs/digits/tail_de0.55413024
146MP0002429_abnormal_blood_cell0.55362663
147MP0003878_abnormal_ear_physiology0.53857002
148MP0005377_hearing/vestibular/ear_phenot0.53857002
149MP0000371_diluted_coat_color0.53261578
150MP0002638_abnormal_pupillary_reflex0.53171377
151MP0001905_abnormal_dopamine_level0.52424345
152MP0002111_abnormal_tail_morphology0.52179530
153MP0003787_abnormal_imprinting0.51997976
154MP0005253_abnormal_eye_physiology0.51520352
155MP0002075_abnormal_coat/hair_pigmentati0.51344805
156MP0004885_abnormal_endolymph0.50013343

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)6.16214732
2Breast hypoplasia (HP:0003187)4.53502936
3Cerebral hypomyelination (HP:0006808)4.36264476
4Impulsivity (HP:0100710)3.88002410
5Abnormality of the labia minora (HP:0012880)3.73517655
6Patellar aplasia (HP:0006443)3.67567888
7Carpal bone hypoplasia (HP:0001498)3.64556767
8Aplasia/Hypoplasia of the patella (HP:0006498)3.53364314
9Rough bone trabeculation (HP:0100670)3.40346810
10Degeneration of anterior horn cells (HP:0002398)3.29109389
11Abnormality of the anterior horn cell (HP:0006802)3.29109389
12Acute necrotizing encephalopathy (HP:0006965)3.16258285
13Ependymoma (HP:0002888)3.09161081
14Meckel diverticulum (HP:0002245)3.09033230
15Medial flaring of the eyebrow (HP:0010747)2.99420332
16CNS hypomyelination (HP:0003429)2.95281140
17Gait imbalance (HP:0002141)2.94462939
18True hermaphroditism (HP:0010459)2.93059355
19Absent radius (HP:0003974)2.92198338
20Chromsome breakage (HP:0040012)2.91812368
21Abnormality of the ileum (HP:0001549)2.91709704
22Abnormal mitochondria in muscle tissue (HP:0008316)2.90233592
23Abnormality of chromosome stability (HP:0003220)2.88248200
24Agnosia (HP:0010524)2.87637365
25Medulloblastoma (HP:0002885)2.87339484
26Colon cancer (HP:0003003)2.84941761
27Chromosomal breakage induced by crosslinking agents (HP:0003221)2.79839568
28Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.79286701
29Aplasia involving forearm bones (HP:0009822)2.77336395
30Absent forearm bone (HP:0003953)2.77336395
31Congenital primary aphakia (HP:0007707)2.76093154
32Ureteral duplication (HP:0000073)2.75549466
33Nephrogenic diabetes insipidus (HP:0009806)2.75218030
34Mitochondrial inheritance (HP:0001427)2.73985423
35Abnormality of the preputium (HP:0100587)2.73597427
36Aplasia/Hypoplasia of the uvula (HP:0010293)2.73123905
37Progressive macrocephaly (HP:0004481)2.69833998
38Acute encephalopathy (HP:0006846)2.69551430
39Rhabdomyosarcoma (HP:0002859)2.68384673
40Increased CSF lactate (HP:0002490)2.66889096
41Limb dystonia (HP:0002451)2.63374871
42Premature ovarian failure (HP:0008209)2.57538604
43Increased hepatocellular lipid droplets (HP:0006565)2.56652793
44Chronic hepatic failure (HP:0100626)2.54163851
45Molar tooth sign on MRI (HP:0002419)2.54005386
46Abnormality of midbrain morphology (HP:0002418)2.54005386
47Pelvic girdle muscle weakness (HP:0003749)2.52233824
48Microretrognathia (HP:0000308)2.51572523
49Lissencephaly (HP:0001339)2.51565251
50Nephronophthisis (HP:0000090)2.48109771
51Lipid accumulation in hepatocytes (HP:0006561)2.46012836
52Myelodysplasia (HP:0002863)2.44899078
53Bone marrow hypocellularity (HP:0005528)2.41984130
54Abnormal trabecular bone morphology (HP:0100671)2.40980370
55Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.39538226
56Abnormality of alanine metabolism (HP:0010916)2.39538226
57Hyperalaninemia (HP:0003348)2.39538226
58Retinal dysplasia (HP:0007973)2.38529815
59Hepatocellular necrosis (HP:0001404)2.37621825
60Atrophy/Degeneration involving motor neurons (HP:0007373)2.36667207
61Duodenal stenosis (HP:0100867)2.36395346
62Small intestinal stenosis (HP:0012848)2.36395346
63Oral leukoplakia (HP:0002745)2.36095111
643-Methylglutaconic aciduria (HP:0003535)2.34090093
65Supernumerary spleens (HP:0009799)2.33560204
66Selective tooth agenesis (HP:0001592)2.29449288
67Sloping forehead (HP:0000340)2.27449001
68Horseshoe kidney (HP:0000085)2.26183510
69Prominent nose (HP:0000448)2.25488747
70Multiple enchondromatosis (HP:0005701)2.24521775
71Cerebral edema (HP:0002181)2.24069793
72Facial hemangioma (HP:0000329)2.22714910
73Cortical dysplasia (HP:0002539)2.22505566
74Absent thumb (HP:0009777)2.22161306
75Renal cortical cysts (HP:0000803)2.21722018
76Hepatic necrosis (HP:0002605)2.21663381
77Myokymia (HP:0002411)2.19768156
78Premature graying of hair (HP:0002216)2.19348848
79Postnatal microcephaly (HP:0005484)2.18279290
80Abnormality of the hip-girdle musculature (HP:0001445)2.17015457
81Abnormality of the musculature of the pelvis (HP:0001469)2.17015457
82Hyperglycinemia (HP:0002154)2.15811979
83Abnormality of the umbilical cord (HP:0010881)2.15082190
84Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.13794180
85Decreased activity of mitochondrial respiratory chain (HP:0008972)2.13794180
86Pancreatic cysts (HP:0001737)2.13650235
87Neoplasm of the pancreas (HP:0002894)2.12662552
88Personality changes (HP:0000751)2.12213785
89Breast aplasia (HP:0100783)2.11688927
90Shoulder girdle muscle weakness (HP:0003547)2.10518935
91Increased serum lactate (HP:0002151)2.09903915
92Vaginal atresia (HP:0000148)2.09811928
93Genital tract atresia (HP:0001827)2.09329367
94Secondary amenorrhea (HP:0000869)2.07596115
95Oligodactyly (HP:0012165)2.07514425
96Optic disc pallor (HP:0000543)2.06692613
97Specific learning disability (HP:0001328)2.06100794
98Pancreatic fibrosis (HP:0100732)2.05193401
99Amyotrophic lateral sclerosis (HP:0007354)2.04597524
100Sclerocornea (HP:0000647)2.04199075
101Tracheoesophageal fistula (HP:0002575)2.03476269
102Aplasia/Hypoplasia of the sternum (HP:0006714)2.03331592
103Postaxial foot polydactyly (HP:0001830)2.01524603
104Pendular nystagmus (HP:0012043)2.01077464
105Stenosis of the external auditory canal (HP:0000402)2.00534512
106Cafe-au-lait spot (HP:0000957)2.00014332
107Abnormality of the renal medulla (HP:0100957)1.99363030
108Abnormality of the duodenum (HP:0002246)1.99052596
109Abnormality of the carotid arteries (HP:0005344)1.98767223
110Degeneration of the lateral corticospinal tracts (HP:0002314)1.98483225
111Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.98483225
112Hypoplasia of the capital femoral epiphysis (HP:0003090)1.97843384
113Glioma (HP:0009733)1.97135097
114Cellular immunodeficiency (HP:0005374)1.96025207
115Progressive inability to walk (HP:0002505)1.94512474
116Oligodactyly (hands) (HP:0001180)1.94362228
117Pachygyria (HP:0001302)1.93342146
118Aplasia/Hypoplasia of the breasts (HP:0010311)1.93178256
119Cleft eyelid (HP:0000625)1.92661928
120Volvulus (HP:0002580)1.92179661
121Abnormal spermatogenesis (HP:0008669)1.91165297
122Abnormality of cells of the erythroid lineage (HP:0012130)1.91114808
123Anencephaly (HP:0002323)1.90978975
124Increased nuchal translucency (HP:0010880)1.90163714
125Lactic acidosis (HP:0003128)1.88137247
126Overlapping toe (HP:0001845)1.87323236
127Glossoptosis (HP:0000162)1.86092038
128Abnormality of the renal cortex (HP:0011035)1.85506113
129Patent foramen ovale (HP:0001655)1.84971258
130Neoplasm of striated muscle (HP:0009728)1.84672586
131Neoplasm of the oral cavity (HP:0100649)1.83255064
132Increased intramyocellular lipid droplets (HP:0012240)1.82767959
133Poor coordination (HP:0002370)1.82660599
134Septo-optic dysplasia (HP:0100842)1.82646280
135Methylmalonic acidemia (HP:0002912)1.81269031
136Postaxial hand polydactyly (HP:0001162)1.81070969
137Astrocytoma (HP:0009592)1.80705944
138Abnormality of the astrocytes (HP:0100707)1.80705944
139Preaxial hand polydactyly (HP:0001177)1.80445570
140Drooling (HP:0002307)1.80130887
141Abnormality of the corticospinal tract (HP:0002492)1.79099710
142Hypoplastic pelvis (HP:0008839)1.78291382
143Male pseudohermaphroditism (HP:0000037)1.78074478
144Reticulocytopenia (HP:0001896)1.77889996
145Renal Fanconi syndrome (HP:0001994)1.77643848
146Agitation (HP:0000713)1.77466628
147Choanal atresia (HP:0000453)1.76976965
148Atresia of the external auditory canal (HP:0000413)1.76595011
149Abnormal lung lobation (HP:0002101)1.76104363
150Amaurosis fugax (HP:0100576)1.75676929
151Dyskinesia (HP:0100660)1.74792063
152Optic nerve hypoplasia (HP:0000609)1.73385644
153Polyphagia (HP:0002591)1.73186142
154Poor suck (HP:0002033)1.73114979
155Abnormality of the metopic suture (HP:0005556)1.72514924
156Abnormal biliary tract morphology (HP:0012440)1.70990315
157Male infertility (HP:0003251)1.70497100
158Muscle fiber atrophy (HP:0100295)1.70297787
159Abnormal number of erythroid precursors (HP:0012131)1.69854618
160Progressive muscle weakness (HP:0003323)1.69577358
161Type 2 muscle fiber atrophy (HP:0003554)1.68998051
162Abnormal neuron morphology (HP:0012757)1.68841005
163Abnormality of the motor neurons (HP:0002450)1.68841005
164Triphalangeal thumb (HP:0001199)1.68751643
165Hepatoblastoma (HP:0002884)1.68407307
166Hypoplasia of the brainstem (HP:0002365)1.66501967
167Aplasia/Hypoplasia of the brainstem (HP:0007362)1.66501967
168Muscular hypotonia of the trunk (HP:0008936)1.65542931
169Leukodystrophy (HP:0002415)1.65019902
170Adrenal hypoplasia (HP:0000835)1.64046409
171Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.64034997
172Anophthalmia (HP:0000528)1.64017014
173Methylmalonic aciduria (HP:0012120)1.63818259
174Decreased testicular size (HP:0008734)1.63610739
175Broad foot (HP:0001769)1.63423016
176Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.61742107
177Excessive salivation (HP:0003781)1.61569346

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.83197641
2WEE14.49295659
3TSSK63.38062328
4NEK23.25648327
5CDC73.20725807
6MARK12.98764091
7TTK2.90575031
8SRPK12.76756773
9BCR2.71916747
10NEK12.69014280
11CASK2.63435039
12TRIM282.60872346
13ACVR1B2.54035143
14CDK192.50194650
15MAP3K42.47841414
16BRSK22.38353129
17MAP2K72.30964214
18ZAK2.25710551
19PLK12.21829176
20PLK42.17921876
21PLK31.99871446
22MKNK21.98195323
23PNCK1.96876777
24DYRK31.95772389
25MAP4K21.93224904
26MAPK131.84975538
27EIF2AK11.79638582
28MKNK11.70294643
29NUAK11.65848579
30STK161.61609205
31NME21.58226336
32CHEK21.55143874
33BRSK11.54797912
34STK38L1.38730101
35PASK1.37588204
36ALK1.37393108
37BMPR1B1.37125316
38CAMKK21.36683898
39BCKDK1.35988836
40ATR1.34429807
41TAF11.31629587
42VRK21.27882238
43EIF2AK31.26129775
44AURKA1.24679319
45RPS6KA41.21683328
46MAP3K91.21624861
47AURKB1.21416911
48BRAF1.20544795
49MINK11.20447793
50CDK71.19823425
51CDK41.19456935
52CCNB11.17270605
53SCYL21.15170060
54MOS1.13953316
55EPHA21.13894047
56ARAF1.10088486
57MAP3K81.08809130
58CDK121.08668261
59MELK1.05769256
60VRK11.05414501
61CDK81.03262347
62CHEK10.99361450
63EEF2K0.98581311
64FRK0.98109721
65EPHA40.97335862
66MAP3K60.97053447
67CSNK1G30.95792394
68NTRK20.93646588
69TNIK0.92474971
70UHMK10.91455797
71CSNK1G10.89096245
72GRK10.86747885
73DYRK20.86177775
74PLK20.85696690
75STK100.85468689
76STK30.85414258
77RPS6KB20.85074208
78CDK20.83820451
79PAK40.83618428
80KSR10.83588298
81OXSR10.82653697
82PRKCG0.82521312
83AKT30.80585289
84MAP2K40.80060201
85TESK20.79834481
86NTRK30.76807207
87LATS20.73459781
88FLT30.72522069
89CDK140.69252989
90BRD40.69125166
91ADRBK20.67697260
92INSRR0.65568614
93PBK0.64291767
94WNK40.64289518
95CSNK1G20.64174798
96SIK20.63851350
97PAK30.63018795
98MAP3K120.59963609
99ATM0.59313393
100CDK180.58535666
101CDK30.58284529
102CDK10.57682563
103PINK10.56615826
104CDK11A0.56601215
105PAK10.55875720
106STK390.55285819
107CAMKK10.54935878
108PRKCI0.54708170
109KSR20.54324411
110BMPR20.53245565
111CDK150.52671605
112CSNK1A1L0.51842467
113CDK60.51683231
114PDK40.51551011
115PDK30.51551011
116MARK30.51142808
117NME10.48859456
118CSNK2A20.46699711
119NLK0.46601527
120CSNK2A10.46382700
121DYRK1B0.45933616
122RAF10.45640049
123ZAP700.44482136
124TAOK20.43680989
125CDK50.42556559
126PRKCQ0.41437842
127CSNK1E0.41366367
128PRKCZ0.40104790
129MAPKAPK50.40047038
130DYRK1A0.39759164
131CSNK1A10.37413269
132CSF1R0.37397304
133WNK30.37200008
134TGFBR10.36305407
135STK110.36268019
136CAMK2A0.36042629
137ERBB30.35247171
138PIM10.35220513
139STK40.35212937
140STK240.31081998
141RPS6KA50.25607564
142MAP2K30.24205608
143MAPK100.22862842
144TYRO30.22817308
145PRKD30.22382811
146MAP3K50.21981648
147CDK90.21616706
148PRKDC0.20457447
149AKT20.20168859
150TLK10.19354149

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030204.29272179
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.16406533
3DNA replication_Homo sapiens_hsa030304.08051712
4Mismatch repair_Homo sapiens_hsa034303.73195714
5RNA transport_Homo sapiens_hsa030133.60177134
6Vitamin B6 metabolism_Homo sapiens_hsa007503.41632776
7Proteasome_Homo sapiens_hsa030503.26782943
8Oxidative phosphorylation_Homo sapiens_hsa001903.26187900
9Spliceosome_Homo sapiens_hsa030403.23659701
10Parkinsons disease_Homo sapiens_hsa050122.97194217
11Cell cycle_Homo sapiens_hsa041102.91149152
12Base excision repair_Homo sapiens_hsa034102.79609693
13Homologous recombination_Homo sapiens_hsa034402.77751281
14Basal transcription factors_Homo sapiens_hsa030222.68640892
15Nucleotide excision repair_Homo sapiens_hsa034202.53003739
16Pyrimidine metabolism_Homo sapiens_hsa002402.38685785
17Steroid biosynthesis_Homo sapiens_hsa001002.14233489
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.12081395
19mRNA surveillance pathway_Homo sapiens_hsa030152.12066558
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.08382148
21Fanconi anemia pathway_Homo sapiens_hsa034602.08281709
22Huntingtons disease_Homo sapiens_hsa050162.02361146
23Nicotine addiction_Homo sapiens_hsa050331.94952494
24Ribosome_Homo sapiens_hsa030101.93508125
25Regulation of autophagy_Homo sapiens_hsa041401.88734378
26RNA degradation_Homo sapiens_hsa030181.88689217
27Oocyte meiosis_Homo sapiens_hsa041141.81319746
28Alzheimers disease_Homo sapiens_hsa050101.67773605
29Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.65931257
30Purine metabolism_Homo sapiens_hsa002301.52016869
31One carbon pool by folate_Homo sapiens_hsa006701.48841663
32Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.45087939
33Epstein-Barr virus infection_Homo sapiens_hsa051691.41874325
34Butanoate metabolism_Homo sapiens_hsa006501.41691771
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.38958966
36Cardiac muscle contraction_Homo sapiens_hsa042601.37978845
37Propanoate metabolism_Homo sapiens_hsa006401.35433546
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.32320243
39p53 signaling pathway_Homo sapiens_hsa041151.28282489
40Non-homologous end-joining_Homo sapiens_hsa034501.24871415
41Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.17620610
42GABAergic synapse_Homo sapiens_hsa047271.13080381
43Collecting duct acid secretion_Homo sapiens_hsa049661.12431043
44Folate biosynthesis_Homo sapiens_hsa007901.08249375
45Antigen processing and presentation_Homo sapiens_hsa046121.01840944
46Fatty acid elongation_Homo sapiens_hsa000621.00492548
47Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.95407175
48Colorectal cancer_Homo sapiens_hsa052100.93520541
49Pyruvate metabolism_Homo sapiens_hsa006200.89198377
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.88043175
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.86027079
52Taste transduction_Homo sapiens_hsa047420.84570804
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.82230042
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.81934014
55Morphine addiction_Homo sapiens_hsa050320.81137592
56Cysteine and methionine metabolism_Homo sapiens_hsa002700.81041528
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79476361
58Dopaminergic synapse_Homo sapiens_hsa047280.76888455
59Herpes simplex infection_Homo sapiens_hsa051680.75447837
60Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.73486678
61Viral carcinogenesis_Homo sapiens_hsa052030.73058104
62Peroxisome_Homo sapiens_hsa041460.72993353
63mTOR signaling pathway_Homo sapiens_hsa041500.71922672
64Circadian rhythm_Homo sapiens_hsa047100.71688754
65Metabolic pathways_Homo sapiens_hsa011000.66995857
66Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.66003261
67Glycerophospholipid metabolism_Homo sapiens_hsa005640.64981418
68Pentose phosphate pathway_Homo sapiens_hsa000300.64135796
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64029436
70Thyroid cancer_Homo sapiens_hsa052160.60860518
71Olfactory transduction_Homo sapiens_hsa047400.58775394
72HTLV-I infection_Homo sapiens_hsa051660.57766273
73Cocaine addiction_Homo sapiens_hsa050300.56010772
74Hippo signaling pathway_Homo sapiens_hsa043900.53559967
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.52874017
76Glutamatergic synapse_Homo sapiens_hsa047240.50957885
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.50081453
78Nitrogen metabolism_Homo sapiens_hsa009100.49376322
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48852741
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.48824038
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48793079
82Fatty acid metabolism_Homo sapiens_hsa012120.48775081
83Alcoholism_Homo sapiens_hsa050340.48572555
84Vibrio cholerae infection_Homo sapiens_hsa051100.48053206
85Phototransduction_Homo sapiens_hsa047440.47057743
86Selenocompound metabolism_Homo sapiens_hsa004500.46332719
87Biosynthesis of amino acids_Homo sapiens_hsa012300.45917388
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45315947
89Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.45125146
90Ether lipid metabolism_Homo sapiens_hsa005650.44925025
91Serotonergic synapse_Homo sapiens_hsa047260.43969810
92Linoleic acid metabolism_Homo sapiens_hsa005910.43539703
93MicroRNAs in cancer_Homo sapiens_hsa052060.41984597
94Fructose and mannose metabolism_Homo sapiens_hsa000510.41702428
95Circadian entrainment_Homo sapiens_hsa047130.41385280
96Amphetamine addiction_Homo sapiens_hsa050310.40326618
97FoxO signaling pathway_Homo sapiens_hsa040680.39646712
98Basal cell carcinoma_Homo sapiens_hsa052170.39625509
99Carbon metabolism_Homo sapiens_hsa012000.38508441
100N-Glycan biosynthesis_Homo sapiens_hsa005100.36408250
101Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35813963
102Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35692650
103Systemic lupus erythematosus_Homo sapiens_hsa053220.35304373
104Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35191388
105Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.34599270
106Endometrial cancer_Homo sapiens_hsa052130.32983761
107alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32960685
108TGF-beta signaling pathway_Homo sapiens_hsa043500.32952066
109Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32505341
110Tryptophan metabolism_Homo sapiens_hsa003800.31964385
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31709074
112Arginine and proline metabolism_Homo sapiens_hsa003300.31375845
113Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.30459597
114beta-Alanine metabolism_Homo sapiens_hsa004100.30170662
115Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.29810216
116Axon guidance_Homo sapiens_hsa043600.29539533
117Protein export_Homo sapiens_hsa030600.29405508
118Chronic myeloid leukemia_Homo sapiens_hsa052200.29266139
119Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.28730612
120Thyroid hormone signaling pathway_Homo sapiens_hsa049190.28526276
121Inositol phosphate metabolism_Homo sapiens_hsa005620.28048014
122Sulfur metabolism_Homo sapiens_hsa009200.27517646
123Notch signaling pathway_Homo sapiens_hsa043300.26668307
124Legionellosis_Homo sapiens_hsa051340.26360643
125NOD-like receptor signaling pathway_Homo sapiens_hsa046210.25314794
126Non-small cell lung cancer_Homo sapiens_hsa052230.24178610
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.23645315
128Neurotrophin signaling pathway_Homo sapiens_hsa047220.22628225
129Transcriptional misregulation in cancer_Homo sapiens_hsa052020.22329655
130Shigellosis_Homo sapiens_hsa051310.21515897
131Hepatitis B_Homo sapiens_hsa051610.20759348
132Prostate cancer_Homo sapiens_hsa052150.20452944
133Sulfur relay system_Homo sapiens_hsa041220.20289613
134Lysosome_Homo sapiens_hsa041420.19174385
135Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.17822552
136Endocytosis_Homo sapiens_hsa041440.17261259
137B cell receptor signaling pathway_Homo sapiens_hsa046620.16373704
138Apoptosis_Homo sapiens_hsa042100.14685852
139Wnt signaling pathway_Homo sapiens_hsa043100.13693480
140Cyanoamino acid metabolism_Homo sapiens_hsa004600.13590599
141Hedgehog signaling pathway_Homo sapiens_hsa043400.13451935
142Pancreatic cancer_Homo sapiens_hsa052120.12581506
143Renal cell carcinoma_Homo sapiens_hsa052110.12160792
144Prolactin signaling pathway_Homo sapiens_hsa049170.11702322
145Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.11134254
146Influenza A_Homo sapiens_hsa051640.10980559
147Acute myeloid leukemia_Homo sapiens_hsa052210.10358429
148Pathways in cancer_Homo sapiens_hsa052000.09357636
149Synaptic vesicle cycle_Homo sapiens_hsa047210.09288539
150Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.08876335
151Central carbon metabolism in cancer_Homo sapiens_hsa052300.07880026
152Prion diseases_Homo sapiens_hsa050200.06945915
153Primary immunodeficiency_Homo sapiens_hsa053400.05834250
154Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.05384015
155Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.05097791

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