PRR11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytoplasmic mRNA processing body assembly (GO:0033962)8.38537007
2negative regulation of multicellular organism growth (GO:0040015)8.26355345
3regulation of memory T cell differentiation (GO:0043380)8.16212640
4regulation of establishment of cell polarity (GO:2000114)7.25478844
5sex differentiation (GO:0007548)6.85039987
6regulation of MHC class I biosynthetic process (GO:0045343)6.48425514
7alternative mRNA splicing, via spliceosome (GO:0000380)6.29533775
8stress granule assembly (GO:0034063)6.07891469
9negative regulation of type 2 immune response (GO:0002829)6.06603914
10regulation of establishment or maintenance of cell polarity (GO:0032878)5.79645141
11regulation of interleukin-13 production (GO:0032656)5.47299739
12centrosome duplication (GO:0051298)5.20689562
13protein localization to kinetochore (GO:0034501)5.18047085
14cholesterol catabolic process (GO:0006707)5.07794527
15sterol catabolic process (GO:0016127)5.07794527
16mitotic sister chromatid segregation (GO:0000070)4.96880930
17mitotic metaphase plate congression (GO:0007080)4.82021787
18kinetochore organization (GO:0051383)4.80154203
19sister chromatid segregation (GO:0000819)4.78518807
20regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.69346951
21protein localization to chromosome, centromeric region (GO:0071459)4.67622062
22regulation of interleukin-5 production (GO:0032674)4.51925603
23kynurenine metabolic process (GO:0070189)4.48584487
24nucleoside diphosphate catabolic process (GO:0009134)4.42955652
25kinetochore assembly (GO:0051382)4.32372800
26metaphase plate congression (GO:0051310)4.29512438
27cerebellar Purkinje cell differentiation (GO:0021702)4.29149993
28microtubule depolymerization (GO:0007019)4.26069140
29response to X-ray (GO:0010165)4.23772324
30establishment of skin barrier (GO:0061436)4.22623002
31nuclear pore complex assembly (GO:0051292)4.20411481
32ADP metabolic process (GO:0046031)4.19195153
33mitotic chromosome condensation (GO:0007076)4.17003592
34negative regulation of receptor-mediated endocytosis (GO:0048261)4.16230931
35nuclear pore organization (GO:0006999)4.14667399
36mitotic sister chromatid cohesion (GO:0007064)4.07731334
37meiotic chromosome segregation (GO:0045132)4.05326669
38attachment of spindle microtubules to kinetochore (GO:0008608)4.04230985
39regulation of spindle organization (GO:0090224)4.03292340
40positive regulation of vasculogenesis (GO:2001214)3.97642594
41establishment of chromosome localization (GO:0051303)3.92291575
42regulation of metalloenzyme activity (GO:0048552)3.92235778
43DNA replication checkpoint (GO:0000076)3.90336252
44regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.88133086
45positive regulation of mitotic sister chromatid separation (GO:1901970)3.81604060
46positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.81604060
47positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.81604060
48positive regulation of chromosome segregation (GO:0051984)3.81406655
49spindle checkpoint (GO:0031577)3.79225098
50CENP-A containing nucleosome assembly (GO:0034080)3.77658837
51DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.75187040
52DNA unwinding involved in DNA replication (GO:0006268)3.73398571
53lipid particle organization (GO:0034389)3.71721203
54DNA replication initiation (GO:0006270)3.69885293
55chromatin remodeling at centromere (GO:0031055)3.67788375
56tryptophan catabolic process (GO:0006569)3.60743225
57indole-containing compound catabolic process (GO:0042436)3.60743225
58indolalkylamine catabolic process (GO:0046218)3.60743225
59regulation of telomere maintenance via telomerase (GO:0032210)3.55555181
60regulation of chromosome segregation (GO:0051983)3.54250344
61DNA replication-independent nucleosome organization (GO:0034724)3.53744246
62DNA replication-independent nucleosome assembly (GO:0006336)3.53744246
63chromosome segregation (GO:0007059)3.52833471
64regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.52119539
65DNA damage response, signal transduction resulting in transcription (GO:0042772)3.51826068
66mitotic nuclear envelope disassembly (GO:0007077)3.50823972
67regulation of water loss via skin (GO:0033561)3.49224566
68telomere maintenance via semi-conservative replication (GO:0032201)3.48911792
69mitotic recombination (GO:0006312)3.48283296
70protein K6-linked ubiquitination (GO:0085020)3.48045571
71protein localization to chromosome (GO:0034502)3.47821900
72DNA strand elongation involved in DNA replication (GO:0006271)3.47118892
73transcription elongation from RNA polymerase III promoter (GO:0006385)3.46970090
74termination of RNA polymerase III transcription (GO:0006386)3.46970090
75regulation of mitotic spindle organization (GO:0060236)3.46858215
76spindle assembly checkpoint (GO:0071173)3.46639688
77protein autoprocessing (GO:0016540)3.43014402
78mitotic spindle checkpoint (GO:0071174)3.42426289
79regulation of mitotic metaphase/anaphase transition (GO:0030071)3.39999998
80negative regulation of chromosome segregation (GO:0051985)3.38777521
81DNA strand elongation (GO:0022616)3.37050056
82DNA replication-dependent nucleosome organization (GO:0034723)3.35624640
83DNA replication-dependent nucleosome assembly (GO:0006335)3.35624640
84regulation of nuclear cell cycle DNA replication (GO:0033262)3.34553389
85telomere maintenance via recombination (GO:0000722)3.34451907
86regulation of DNA endoreduplication (GO:0032875)3.32365103
87L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.31487066
88pore complex assembly (GO:0046931)3.30793456
89regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.30596820
90negative regulation of mitotic sister chromatid segregation (GO:0033048)3.29832749
91negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.29832749
92negative regulation of sister chromatid segregation (GO:0033046)3.29832749
93negative regulation of mitotic sister chromatid separation (GO:2000816)3.29832749
94mitotic spindle assembly checkpoint (GO:0007094)3.29109205
95regulation of mitotic sister chromatid separation (GO:0010965)3.28283243
96regulation of mitotic sister chromatid segregation (GO:0033047)3.28283243
97regulation of sister chromatid segregation (GO:0033045)3.28283243
98negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.28217991
99spindle assembly (GO:0051225)3.26474618
100regulation of vasculogenesis (GO:2001212)3.26327635
101membrane disassembly (GO:0030397)3.24418999
102nuclear envelope disassembly (GO:0051081)3.24418999
103histone exchange (GO:0043486)3.23198863
104negative regulation of DNA-dependent DNA replication (GO:2000104)3.21828446
105regulation of sister chromatid cohesion (GO:0007063)3.20453858
106negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.17962967
107regulation of gene silencing by RNA (GO:0060966)3.17043001
108regulation of posttranscriptional gene silencing (GO:0060147)3.17043001
109regulation of gene silencing by miRNA (GO:0060964)3.17043001
110somatic hypermutation of immunoglobulin genes (GO:0016446)3.12264179
111somatic diversification of immune receptors via somatic mutation (GO:0002566)3.12264179
112microtubule polymerization or depolymerization (GO:0031109)3.12169934
113acrosome assembly (GO:0001675)3.11856504
114somite rostral/caudal axis specification (GO:0032525)3.11560591
115DNA topological change (GO:0006265)3.11288818
116negative regulation of endothelial cell apoptotic process (GO:2000352)3.09947154
117tryptophan metabolic process (GO:0006568)3.09775571
118mitotic G2/M transition checkpoint (GO:0044818)3.09586147
119RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)3.02829111
120DNA synthesis involved in DNA repair (GO:0000731)3.00982997
121bile acid biosynthetic process (GO:0006699)2.97956582
122chromosome condensation (GO:0030261)2.95944239
123positive regulation of fatty acid beta-oxidation (GO:0032000)2.95729292
124telomere maintenance via telomere lengthening (GO:0010833)2.94199153
125regulation of centrosome cycle (GO:0046605)2.91977754
126maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.91820613
127chromatin assembly or disassembly (GO:0006333)2.91546103
128regulation of action potential (GO:0098900)2.90354037
129nucleotide-excision repair, DNA gap filling (GO:0006297)2.88532801
130centrosome organization (GO:0051297)2.86492329
131ATP-dependent chromatin remodeling (GO:0043044)2.85662614
132regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.85237963
133regulation of mitotic spindle checkpoint (GO:1903504)2.85237963
134negative regulation of cell cycle G2/M phase transition (GO:1902750)2.84266365
135negative regulation of endothelial cell proliferation (GO:0001937)2.82807959
136DNA packaging (GO:0006323)2.81427101
137DNA duplex unwinding (GO:0032508)2.78562646
138DNA geometric change (GO:0032392)2.78407547
139regulation of histone H3-K9 methylation (GO:0051570)2.77824279
140DNA ligation (GO:0006266)2.77691564
141regulation of double-strand break repair via homologous recombination (GO:0010569)2.75289562
142positive regulation of DNA-dependent DNA replication (GO:2000105)2.73387359
143estrogen biosynthetic process (GO:0006703)2.73152189
144DNA strand renaturation (GO:0000733)2.71584885
145DNA conformation change (GO:0071103)2.69882747
146replication fork processing (GO:0031297)2.69227071
147regulation of DNA-dependent DNA replication (GO:0090329)2.69071675
148regulation of double-strand break repair (GO:2000779)2.68741630
149regulation of spindle checkpoint (GO:0090231)2.67313113
150mitotic DNA integrity checkpoint (GO:0044774)2.64760735
151sister chromatid cohesion (GO:0007062)2.58841100
152regulation of RNA export from nucleus (GO:0046831)2.57899803
153notochord development (GO:0030903)2.57806686
154DNA double-strand break processing (GO:0000729)2.56272657

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human7.66656714
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human5.25296618
3* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.68583928
4TP63_19390658_ChIP-ChIP_HaCaT_Human3.47515580
5VDR_22108803_ChIP-Seq_LS180_Human3.38961728
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.03848653
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.86804524
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.65134596
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.56162633
10* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.55514411
11AR_21909140_ChIP-Seq_LNCAP_Human2.52214349
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.36532793
13* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.34259544
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.31698866
15E2F1_21310950_ChIP-Seq_MCF-7_Human2.26579356
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.23120483
17* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.21647771
18TAF15_26573619_Chip-Seq_HEK293_Human2.05423714
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.04389904
20E2F7_22180533_ChIP-Seq_HELA_Human10.7616672
21EST1_17652178_ChIP-ChIP_JURKAT_Human1.98684398
22CREB1_15753290_ChIP-ChIP_HEK293T_Human1.90726861
23NELFA_20434984_ChIP-Seq_ESCs_Mouse1.86245612
24SALL1_21062744_ChIP-ChIP_HESCs_Human1.84281143
25* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.78292471
26RBPJ_22232070_ChIP-Seq_NCS_Mouse1.74946742
27EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.73832729
28KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.73323987
29KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.73323987
30KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.73323987
31ELK1_19687146_ChIP-ChIP_HELA_Human1.71632772
32* XRN2_22483619_ChIP-Seq_HELA_Human1.67987579
33ZNF274_21170338_ChIP-Seq_K562_Hela1.62189084
34YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60423099
35* VDR_23849224_ChIP-Seq_CD4+_Human1.59917149
36GABP_17652178_ChIP-ChIP_JURKAT_Human1.59101628
37* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.55091556
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.54498460
39BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.51885609
40ETS1_20019798_ChIP-Seq_JURKAT_Human1.49950282
41FUS_26573619_Chip-Seq_HEK293_Human1.49821378
42TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.47734772
43TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.45592809
44POU5F1_16153702_ChIP-ChIP_HESCs_Human1.42959719
45CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.42922414
46* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.42144673
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.39363461
48* FOXP3_21729870_ChIP-Seq_TREG_Human1.36370717
49SOX2_18555785_ChIP-Seq_MESCs_Mouse1.35733986
50TTF2_22483619_ChIP-Seq_HELA_Human1.34550761
51PADI4_21655091_ChIP-ChIP_MCF-7_Human1.34389082
52HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.34056455
53JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.32481625
54SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.28763789
55BCAT_22108803_ChIP-Seq_LS180_Human1.26299565
56RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25409601
57DCP1A_22483619_ChIP-Seq_HELA_Human1.23928640
58PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23279887
59CIITA_25753668_ChIP-Seq_RAJI_Human1.22565017
60IGF1R_20145208_ChIP-Seq_DFB_Human1.21598692
61* ER_23166858_ChIP-Seq_MCF-7_Human1.21246114
62ELF1_17652178_ChIP-ChIP_JURKAT_Human1.18863876
63POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.18568540
64E2F1_18555785_ChIP-Seq_MESCs_Mouse1.15928793
65HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.15760379
66KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.15084780
67SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.13240594
68SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.12914873
69LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10930437
70E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.07844570
71NOTCH1_21737748_ChIP-Seq_TLL_Human1.07678679
72FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.07237985
73KDM5A_27292631_Chip-Seq_BREAST_Human1.06592925
74EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06452191
75* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.06369355
76MYC_22102868_ChIP-Seq_BL_Human1.05675476
77HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.03747249
78EWS_26573619_Chip-Seq_HEK293_Human1.03704897
79SOX2_16153702_ChIP-ChIP_HESCs_Human1.03252783
80E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01319378
81IRF1_19129219_ChIP-ChIP_H3396_Human1.00915147
82MYC_18940864_ChIP-ChIP_HL60_Human1.00331385
83MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00200148
84CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.99964977
85ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.99571252
86SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.99147800
87GABP_19822575_ChIP-Seq_HepG2_Human0.98354412
88* NANOG_21062744_ChIP-ChIP_HESCs_Human0.96439194
89ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96061566
90POU3F2_20337985_ChIP-ChIP_501MEL_Human0.95758768
91ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.95687774
92NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.94673583
93CTBP1_25329375_ChIP-Seq_LNCAP_Human0.93744766
94NANOG_16153702_ChIP-ChIP_HESCs_Human0.92976728
95* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.92194321
96* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.91369660
97OCT1_27270436_Chip-Seq_PROSTATE_Human0.91271867
98GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88762327
99THAP11_20581084_ChIP-Seq_MESCs_Mouse0.88705778
100NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.88593000
101FOXA1_27270436_Chip-Seq_PROSTATE_Human0.88569835
102FOXA1_25329375_ChIP-Seq_VCAP_Human0.88569835
103* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.86478390
104ZFP57_27257070_Chip-Seq_ESCs_Mouse0.85937492
105FOXM1_26456572_ChIP-Seq_MCF-7_Human0.84653200
106* NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.84105962
107SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.83858028
108SRF_21415370_ChIP-Seq_HL-1_Mouse0.82916113
109POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.81969998
110CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.81819801
111YY1_21170310_ChIP-Seq_MESCs_Mouse0.80655209
112TDRD3_21172665_ChIP-Seq_MCF-7_Human0.80430488
113TCF3_18692474_ChIP-Seq_MEFs_Mouse0.80404398
114PKCTHETA_26484144_Chip-Seq_BREAST_Human0.80385261
115DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.77207344
116KAP1_22055183_ChIP-Seq_ESCs_Mouse0.75996004
117ZFX_18555785_ChIP-Seq_MESCs_Mouse0.75791767
118SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.74592986
119TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.73863651
120SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.72561910
121NCOR_22424771_ChIP-Seq_293T_Human0.72494154
122CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.71744246
123PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.71408693
124* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.71285022
125POU5F1_16518401_ChIP-PET_MESCs_Mouse0.71158980
126TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.70345181
127MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.69655087
128UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.69484609
129FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.69167258
130TP53_22573176_ChIP-Seq_HFKS_Human0.68139867
131CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.67168717
132* NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.66894662
133ERG_20887958_ChIP-Seq_HPC-7_Mouse0.66649563
134SOX17_20123909_ChIP-Seq_XEN_Mouse0.66372575
135TBL1_22424771_ChIP-Seq_293T_Human0.63130437
136CDX2_22108803_ChIP-Seq_LS180_Human0.63117592
137SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.62317208
138* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.61355053
139FLI1_27457419_Chip-Seq_LIVER_Mouse0.61138081
140TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.60842477

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003252_abnormal_bile_duct4.63238408
2MP0008057_abnormal_DNA_replication4.34150693
3MP0003011_delayed_dark_adaptation3.94362723
4MP0003111_abnormal_nucleus_morphology3.74279513
5MP0010094_abnormal_chromosome_stability3.56103670
6MP0003693_abnormal_embryo_hatching3.48734999
7MP0003941_abnormal_skin_development3.39170378
8MP0002736_abnormal_nociception_after3.23992006
9MP0000569_abnormal_digit_pigmentation3.15245721
10MP0003077_abnormal_cell_cycle3.11435651
11MP0004957_abnormal_blastocyst_morpholog2.83019984
12MP0008058_abnormal_DNA_repair2.59441603
13MP0008007_abnormal_cellular_replicative2.25751091
14MP0006292_abnormal_olfactory_placode2.17362892
15MP0008932_abnormal_embryonic_tissue2.15337554
16MP0000371_diluted_coat_color2.15326867
17MP0010030_abnormal_orbit_morphology2.14751579
18MP0001968_abnormal_touch/_nociception2.06560930
19MP0002796_impaired_skin_barrier2.00032123
20MP0002396_abnormal_hematopoietic_system1.99045411
21MP0001986_abnormal_taste_sensitivity1.88092175
22MP0009697_abnormal_copulation1.87342003
23MP0002234_abnormal_pharynx_morphology1.84746950
24MP0003121_genomic_imprinting1.81843716
25MP0000350_abnormal_cell_proliferation1.80722264
26MP0010307_abnormal_tumor_latency1.79417545
27MP0003786_premature_aging1.77127091
28MP0006072_abnormal_retinal_apoptosis1.73337110
29MP0000566_synostosis1.73322933
30MP0003890_abnormal_embryonic-extraembry1.69055776
31MP0005501_abnormal_skin_physiology1.68934429
32MP0005076_abnormal_cell_differentiation1.67158166
33MP0005451_abnormal_body_composition1.62106816
34MP0005253_abnormal_eye_physiology1.61338776
35MP0006035_abnormal_mitochondrial_morpho1.60306811
36MP0005083_abnormal_biliary_tract1.58202475
37MP0005380_embryogenesis_phenotype1.51418397
38MP0001672_abnormal_embryogenesis/_devel1.51418397
39MP0008877_abnormal_DNA_methylation1.50350499
40MP0002085_abnormal_embryonic_tissue1.48788769
41MP0001293_anophthalmia1.46996561
42MP0003937_abnormal_limbs/digits/tail_de1.45210275
43MP0004197_abnormal_fetal_growth/weight/1.44581647
44MP0001730_embryonic_growth_arrest1.44328645
45MP0003186_abnormal_redox_activity1.42560895
46MP0003938_abnormal_ear_development1.41509953
47MP0003119_abnormal_digestive_system1.41115632
48MP0002938_white_spotting1.39327770
49MP0004808_abnormal_hematopoietic_stem1.38865416
50MP0000427_abnormal_hair_cycle1.37345826
51MP0003123_paternal_imprinting1.36534157
52MP0002084_abnormal_developmental_patter1.32923433
53MP0005646_abnormal_pituitary_gland1.32361641
54MP0001697_abnormal_embryo_size1.30714343
55MP0005171_absent_coat_pigmentation1.30486635
56MP0003984_embryonic_growth_retardation1.27558651
57MP0003950_abnormal_plasma_membrane1.27261828
58MP0002088_abnormal_embryonic_growth/wei1.23460633
59MP0002282_abnormal_trachea_morphology1.23456913
60MP0005174_abnormal_tail_pigmentation1.22917935
61MP0000383_abnormal_hair_follicle1.20577805
62MP0009384_cardiac_valve_regurgitation1.20118774
63MP0002837_dystrophic_cardiac_calcinosis1.19300925
64MP0002102_abnormal_ear_morphology1.19188645
65MP0000490_abnormal_crypts_of1.19128761
66MP0002092_abnormal_eye_morphology1.18063621
67MP0001286_abnormal_eye_development1.17265513
68MP0003755_abnormal_palate_morphology1.16584997
69MP0002086_abnormal_extraembryonic_tissu1.16227880
70MP0000432_abnormal_head_morphology1.14212051
71MP0000049_abnormal_middle_ear1.14169161
72MP0003122_maternal_imprinting1.14080046
73MP0002075_abnormal_coat/hair_pigmentati1.09922514
74MP0000653_abnormal_sex_gland1.09024087
75MP0002080_prenatal_lethality1.07874794
76MP0000428_abnormal_craniofacial_morphol1.07423943
77MP0005408_hypopigmentation1.06988095
78MP0002249_abnormal_larynx_morphology1.04246562
79MP0004381_abnormal_hair_follicle1.03670619
80MP0002009_preneoplasia1.03646321
81MP0003936_abnormal_reproductive_system1.02501388
82MP0009703_decreased_birth_body1.01656637
83MP0010678_abnormal_skin_adnexa1.00955399
84MP0010352_gastrointestinal_tract_polyps1.00527281
85MP0003567_abnormal_fetal_cardiomyocyte0.99729722
86MP0000313_abnormal_cell_death0.99634880
87MP0003935_abnormal_craniofacial_develop0.97748932
88MP0005391_vision/eye_phenotype0.97554186
89MP0003315_abnormal_perineum_morphology0.97519170
90MP0005647_abnormal_sex_gland0.97229230
91MP0008961_abnormal_basal_metabolism0.96463158
92MP0002697_abnormal_eye_size0.95663232
93MP0005623_abnormal_meninges_morphology0.95342437
94MP0000358_abnormal_cell_content/0.94587260
95MP0002932_abnormal_joint_morphology0.92946983
96MP0003718_maternal_effect0.92070372
97MP0004233_abnormal_muscle_weight0.92057540
98MP0009333_abnormal_splenocyte_physiolog0.91815704
99MP0002111_abnormal_tail_morphology0.91461667
100MP0009250_abnormal_appendicular_skeleto0.90475262
101MP0002210_abnormal_sex_determination0.89413585
102MP0002019_abnormal_tumor_incidence0.88897328
103MP0002163_abnormal_gland_morphology0.88472034
104MP0001186_pigmentation_phenotype0.88355935
105MP0001216_abnormal_epidermal_layer0.88046731
106MP0000762_abnormal_tongue_morphology0.87148285
107MP0000703_abnormal_thymus_morphology0.85679683
108MP0005551_abnormal_eye_electrophysiolog0.85615072
109MP0005075_abnormal_melanosome_morpholog0.84386035
110MP0003942_abnormal_urinary_system0.83967060
111MP0002161_abnormal_fertility/fecundity0.83509716
112MP0003385_abnormal_body_wall0.82395367
113MP0001529_abnormal_vocalization0.82169657
114MP0003136_yellow_coat_color0.82165381
115MP0004264_abnormal_extraembryonic_tissu0.81353453
116MP0002116_abnormal_craniofacial_bone0.81131686
117MP0001188_hyperpigmentation0.80317661
118MP0000647_abnormal_sebaceous_gland0.80010612
119MP0001145_abnormal_male_reproductive0.79407782
120MP0009672_abnormal_birth_weight0.79161921
121MP0003699_abnormal_female_reproductive0.78957325
122MP0003195_calcinosis0.78673795
123MP0001119_abnormal_female_reproductive0.78422380
124MP0004147_increased_porphyrin_level0.77899845
125MP0005334_abnormal_fat_pad0.77748734
126MP0000516_abnormal_urinary_system0.77695975
127MP0005367_renal/urinary_system_phenotyp0.77695975
128MP0005508_abnormal_skeleton_morphology0.77691241
129MP0002114_abnormal_axial_skeleton0.77587702
130MP0008770_decreased_survivor_rate0.77492291
131MP0004947_skin_inflammation0.77294313
132MP0001346_abnormal_lacrimal_gland0.76033113
133MP0008789_abnormal_olfactory_epithelium0.76016467
134MP0003861_abnormal_nervous_system0.75921554
135MP0002160_abnormal_reproductive_system0.75906182
136MP0009053_abnormal_anal_canal0.75790936
137MP0000631_abnormal_neuroendocrine_gland0.75392381
138MP0008995_early_reproductive_senescence0.74871405
139MP0002233_abnormal_nose_morphology0.74735911
140MP0000537_abnormal_urethra_morphology0.74398376
141MP0003646_muscle_fatigue0.74123881
142MP0002098_abnormal_vibrissa_morphology0.73745008
143MP0002751_abnormal_autonomic_nervous0.73376761
144MP0009745_abnormal_behavioral_response0.73168874
145MP0000733_abnormal_muscle_development0.72641255
146MP0002177_abnormal_outer_ear0.72266731
147MP0005395_other_phenotype0.72187358
148MP0002109_abnormal_limb_morphology0.68410313
149MP0002060_abnormal_skin_morphology0.68244476

Predicted human phenotypes

RankGene SetZ-score
1Genetic anticipation (HP:0003743)9.04679831
2Dysmetric saccades (HP:0000641)8.25092094
3Action tremor (HP:0002345)7.17382088
4Progressive cerebellar ataxia (HP:0002073)6.10797617
5Pendular nystagmus (HP:0012043)5.99784745
6Chromosomal breakage induced by crosslinking agents (HP:0003221)5.00655215
7Chromsome breakage (HP:0040012)4.90795183
8Abnormality of the hepatic vasculature (HP:0006707)4.32575209
9Absence seizures (HP:0002121)4.17103326
10Gaze-evoked nystagmus (HP:0000640)4.15927483
11Slow saccadic eye movements (HP:0000514)3.94623247
12Urinary bladder sphincter dysfunction (HP:0002839)3.86742839
13Postural tremor (HP:0002174)3.77210320
14Severe visual impairment (HP:0001141)3.49178422
15Aplasia/Hypoplasia of the uvula (HP:0010293)3.41354706
16Meckel diverticulum (HP:0002245)3.38627160
17Dysdiadochokinesis (HP:0002075)3.26082493
18Abnormality of the ileum (HP:0001549)3.25134064
19Volvulus (HP:0002580)3.22993082
20Abnormality of the prostate (HP:0008775)3.21703369
21Impaired smooth pursuit (HP:0007772)3.17234249
22Abnormality of chromosome stability (HP:0003220)3.15274817
23Impaired proprioception (HP:0010831)3.12440940
24Limb ataxia (HP:0002070)3.09589576
25Postural instability (HP:0002172)3.07404838
26Impaired vibratory sensation (HP:0002495)3.06610593
27Postnatal microcephaly (HP:0005484)3.06353388
28Dialeptic seizures (HP:0011146)3.04139725
29Duodenal stenosis (HP:0100867)3.00997177
30Small intestinal stenosis (HP:0012848)3.00997177
31Ectopic kidney (HP:0000086)2.97809264
32Abnormality of the preputium (HP:0100587)2.97433070
33Birth length less than 3rd percentile (HP:0003561)2.94469217
34Patellar aplasia (HP:0006443)2.92368678
35Nephroblastoma (Wilms tumor) (HP:0002667)2.86221562
36Impulsivity (HP:0100710)2.74261202
37Aplasia/Hypoplasia of the patella (HP:0006498)2.73265338
38Chorioretinal atrophy (HP:0000533)2.73014934
39Breast hypoplasia (HP:0003187)2.71558844
40Increased nuchal translucency (HP:0010880)2.68815241
41Absent radius (HP:0003974)2.67992333
42Embryonal renal neoplasm (HP:0011794)2.65913198
43Abnormality of the labia minora (HP:0012880)2.63216686
44Duplicated collecting system (HP:0000081)2.62931465
45Absent forearm bone (HP:0003953)2.52143454
46Aplasia involving forearm bones (HP:0009822)2.52143454
47Abnormal lung lobation (HP:0002101)2.49844480
48Abnormality of the renal collecting system (HP:0004742)2.43891382
49Abnormality of the duodenum (HP:0002246)2.43876277
50Congenital ichthyosiform erythroderma (HP:0007431)2.41166652
51Focal seizures (HP:0007359)2.38120260
52Abnormal number of incisors (HP:0011064)2.37884696
53Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.33666501
54Short 4th metacarpal (HP:0010044)2.33666501
55Abnormality of macular pigmentation (HP:0008002)2.31501153
56Oligodactyly (HP:0012165)2.29847388
57Abnormality of the carotid arteries (HP:0005344)2.21847117
58Myelodysplasia (HP:0002863)2.19828606
59Rib fusion (HP:0000902)2.18861671
60Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.18415618
61Proximal placement of thumb (HP:0009623)2.14396571
62Oculomotor apraxia (HP:0000657)2.13689753
63Facial hemangioma (HP:0000329)2.10768468
64Short middle phalanx of the 5th finger (HP:0004220)2.10144569
65Selective tooth agenesis (HP:0001592)2.09475922
66Pancreatic cysts (HP:0001737)2.09324107
67Deviation of the thumb (HP:0009603)2.08197030
68Triphalangeal thumb (HP:0001199)2.08152738
69Oligodactyly (hands) (HP:0001180)2.06736161
70Increased corneal curvature (HP:0100692)2.06509923
71Keratoconus (HP:0000563)2.06509923
72Atresia of the external auditory canal (HP:0000413)2.05803565
73Sloping forehead (HP:0000340)2.05407496
74Abnormality of male internal genitalia (HP:0000022)2.04226359
75Abnormality of chromosome segregation (HP:0002916)2.02429846
76Clubbing of toes (HP:0100760)2.01871280
77Carpal bone hypoplasia (HP:0001498)2.01682539
78Short thumb (HP:0009778)1.96938504
79Multiple enchondromatosis (HP:0005701)1.96410371
80Medulloblastoma (HP:0002885)1.95414263
81Biliary tract neoplasm (HP:0100574)1.94882514
82Tracheoesophageal fistula (HP:0002575)1.93703639
83Vitreoretinal degeneration (HP:0000655)1.93337839
84Areflexia of lower limbs (HP:0002522)1.92492149
85Sclerocornea (HP:0000647)1.91409481
86Abnormality of ocular smooth pursuit (HP:0000617)1.90510189
87Bone marrow hypocellularity (HP:0005528)1.89992004
88Aplasia/Hypoplasia of the sternum (HP:0006714)1.88736991
89Tinnitus (HP:0000360)1.88717395
90Long eyelashes (HP:0000527)1.88191092
91Supernumerary bones of the axial skeleton (HP:0009144)1.87468999
92Pancreatic fibrosis (HP:0100732)1.86947958
93High pitched voice (HP:0001620)1.84853784
94True hermaphroditism (HP:0010459)1.84315989
95Ependymoma (HP:0002888)1.83879390
96Supernumerary spleens (HP:0009799)1.82812445
97Abnormality of the anterior horn cell (HP:0006802)1.82330683
98Degeneration of anterior horn cells (HP:0002398)1.82330683
99Abnormality of the incisor (HP:0000676)1.80940344
100Supernumerary ribs (HP:0005815)1.80385772
101Gangrene (HP:0100758)1.77991478
102Rhabdomyosarcoma (HP:0002859)1.75973284
103Glioma (HP:0009733)1.75633658
104Small epiphyses (HP:0010585)1.74610229
105Renal duplication (HP:0000075)1.73566773
106Abnormality of nail color (HP:0100643)1.73302444
107Small hand (HP:0200055)1.73240978
108Aplasia/Hypoplasia of the earlobes (HP:0009906)1.72688337
109Abnormality of DNA repair (HP:0003254)1.72678498
110Ectropion (HP:0000656)1.72624888
111Prostate neoplasm (HP:0100787)1.72402773
112Retinitis pigmentosa (HP:0000510)1.71549804
113Severe Myopia (HP:0011003)1.71127426
114Bilateral microphthalmos (HP:0007633)1.70661053
115Concave nail (HP:0001598)1.69630770
116Choanal atresia (HP:0000453)1.69082948
117Reticulocytopenia (HP:0001896)1.68744562
118Abnormality of abdominal situs (HP:0011620)1.67628121
119Abdominal situs inversus (HP:0003363)1.67628121
120Deep philtrum (HP:0002002)1.67502323
121Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.66995177
122Hypochromic microcytic anemia (HP:0004840)1.65755690
123Increased number of teeth (HP:0011069)1.65000596
124Horseshoe kidney (HP:0000085)1.64646052
125Eczematoid dermatitis (HP:0000976)1.60967387
126Astrocytoma (HP:0009592)1.59731920
127Abnormality of the astrocytes (HP:0100707)1.59731920
128Acute lymphatic leukemia (HP:0006721)1.59592516
129Cortical dysplasia (HP:0002539)1.59283814
130Absent thumb (HP:0009777)1.58949815
131Cafe-au-lait spot (HP:0000957)1.58703171
132Hypoplastic iliac wings (HP:0002866)1.58376224
133Abnormality of midbrain morphology (HP:0002418)1.58230184
134Molar tooth sign on MRI (HP:0002419)1.58230184
135Microtia (HP:0008551)1.58088713
136Proximal tubulopathy (HP:0000114)1.58030211
137Hypochromic anemia (HP:0001931)1.57774414
138Prominent nose (HP:0000448)1.57577870
139Mesomelia (HP:0003027)1.57292390
140Aplasia/hypoplasia of the humerus (HP:0006507)1.54521296
141Clumsiness (HP:0002312)1.53982568
142Hypoplasia of the capital femoral epiphysis (HP:0003090)1.53843899
143Lip pit (HP:0100267)1.53295813
144Septo-optic dysplasia (HP:0100842)1.53169400
145Abnormality of vision evoked potentials (HP:0000649)1.51848662
146Skull defect (HP:0001362)1.51847375
147Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.51391194
148Syringomyelia (HP:0003396)1.50892414
149Spinal cord lesions (HP:0100561)1.50892414
150Stenosis of the external auditory canal (HP:0000402)1.50880685
151Premature ovarian failure (HP:0008209)1.50476279
152Neoplasm of striated muscle (HP:0009728)1.49057873
153Fair hair (HP:0002286)1.48957220
154Fasciculations (HP:0002380)1.48388712
155Abnormality of the pons (HP:0007361)1.47988965
156Abnormality of saccadic eye movements (HP:0000570)1.47766170
157Embryonal neoplasm (HP:0002898)1.47533120
158Abnormal number of erythroid precursors (HP:0012131)1.45425621
159Colon cancer (HP:0003003)1.44076931
160Hypoplasia of the pons (HP:0012110)1.42987979
161Abnormality of alanine metabolism (HP:0010916)1.42459437
162Hyperalaninemia (HP:0003348)1.42459437
163Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.42459437
164Aplasia/Hypoplasia of the fovea (HP:0008060)1.41226593

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK198.15414355
2OXSR14.24345975
3BUB14.23131269
4CDC74.02188685
5FRK3.87718833
6CDK123.83824525
7NEK23.17368077
8WEE13.10326230
9TTK2.99429597
10SRPK12.82972844
11VRK22.80264713
12BRSK22.41965376
13MKNK12.26801845
14PLK12.21004086
15MKNK22.10952950
16CHEK22.09288193
17BRD42.07722624
18TAF12.02714754
19PLK41.95539585
20AURKB1.94194830
21ZAK1.90709151
22STK41.83021797
23PLK31.80290005
24CDK71.79008548
25GRK11.76012960
26EIF2AK31.72761724
27STK31.63638882
28ATR1.62656681
29STK101.58282700
30BMPR1B1.57156011
31EIF2AK11.56310371
32LATS11.55302261
33MAP3K71.44973674
34CHEK11.44000259
35VRK11.40274234
36AURKA1.38902530
37EIF2AK21.35971012
38CDK41.31850081
39BRSK11.30476898
40DYRK31.28351397
41TLK11.25993577
42SIK31.25495027
43ATM1.19447092
44CCNB11.07454334
45CDK61.05408473
46AKT31.04452359
47SMG11.03385744
48FGFR10.98164827
49RPS6KB20.96880941
50CDK20.90368383
51WNK40.90141023
52MAP3K100.89664236
53IRAK20.87093706
54CDK10.85991552
55MAP3K80.85714121
56STK38L0.85434383
57IRAK40.85407763
58CLK10.85319057
59BCR0.84232593
60EPHA20.83675760
61NUAK10.82158307
62PIM10.79468018
63TSSK60.78326785
64PBK0.76635414
65TGFBR10.75995247
66IRAK30.74635359
67NEK10.74044878
68MELK0.73632730
69RPS6KA40.73099753
70YES10.72365836
71TNK20.70483883
72MST1R0.70184892
73GRK60.66966752
74STK160.62438191
75PNCK0.61896739
76LIMK10.61769463
77CDK80.61595891
78MAPKAPK50.60752471
79ERBB30.59304853
80MARK30.57406768
81TRPM70.57119222
82PASK0.57014945
83CDK90.56255002
84ACVR1B0.55589044
85PRKCI0.54649587
86CDK30.54036528
87CDK150.51969012
88CDK180.51305142
89TESK20.51062095
90EPHB20.50945938
91PAK40.50660056
92NME20.49066071
93MAPKAPK20.48117660
94CDK11A0.46628013
95KSR10.45834299
96LATS20.45756290
97AKT20.45625283
98CHUK0.44903750
99PAK10.44523772
100MET0.43283323
101BMX0.42823586
102STK110.42800341
103CSNK2A10.42564793
104ERBB40.41944561
105STK240.40806920
106RPS6KA50.40366795
107CSF1R0.40115429
108TRIM280.40014660
109MTOR0.39804174
110MAPK140.39761968
111ERBB20.39101569
112ADRBK20.39008857
113TEC0.37738296
114PINK10.36769398
115EEF2K0.35940034
116CSNK1A1L0.35701130
117BTK0.35523717
118TXK0.35247945
119CSNK2A20.35215893
120CDC42BPA0.35203290
121PRKDC0.35177206
122ALK0.35109313
123GRK50.34422067
124CDK140.34323943
125FGR0.34171737
126NME10.32797001
127MST40.32601047
128CSNK1D0.32021291
129WNK30.26258168
130BRAF0.21264346
131ADRBK10.20381503
132SCYL20.20020614
133INSRR0.19250387
134AKT10.18015944
135FER0.17065547
136CSNK1E0.13189916
137PRKCG0.11527408
138CSNK1A10.11362349
139STK380.10809901

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.88253616
2DNA replication_Homo sapiens_hsa030303.95679442
3Mismatch repair_Homo sapiens_hsa034303.30933455
4Cell cycle_Homo sapiens_hsa041103.25377693
5Fanconi anemia pathway_Homo sapiens_hsa034603.06343448
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.94881918
7Homologous recombination_Homo sapiens_hsa034402.91269976
8Spliceosome_Homo sapiens_hsa030402.70724711
9RNA transport_Homo sapiens_hsa030132.59959832
10Base excision repair_Homo sapiens_hsa034102.51195620
11Nucleotide excision repair_Homo sapiens_hsa034202.41550046
12RNA polymerase_Homo sapiens_hsa030202.41493843
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.37303092
14Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.19607125
15Non-homologous end-joining_Homo sapiens_hsa034502.12734390
16Basal transcription factors_Homo sapiens_hsa030222.09228586
17p53 signaling pathway_Homo sapiens_hsa041151.98357894
18Cysteine and methionine metabolism_Homo sapiens_hsa002701.94071428
19mRNA surveillance pathway_Homo sapiens_hsa030151.91295496
20RNA degradation_Homo sapiens_hsa030181.69986175
21One carbon pool by folate_Homo sapiens_hsa006701.69924191
22Pyrimidine metabolism_Homo sapiens_hsa002401.68250346
23Vitamin B6 metabolism_Homo sapiens_hsa007501.50823355
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.49138426
25Ribosome_Homo sapiens_hsa030101.44136844
26MicroRNAs in cancer_Homo sapiens_hsa052061.42843329
27Fatty acid biosynthesis_Homo sapiens_hsa000611.39069815
28Pyruvate metabolism_Homo sapiens_hsa006201.39029111
29Caffeine metabolism_Homo sapiens_hsa002321.37384578
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.33772520
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.33486508
32Propanoate metabolism_Homo sapiens_hsa006401.31543520
33Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.31227179
34Basal cell carcinoma_Homo sapiens_hsa052171.29247428
35Proteasome_Homo sapiens_hsa030501.28793806
36Selenocompound metabolism_Homo sapiens_hsa004501.27184564
37Oocyte meiosis_Homo sapiens_hsa041141.23969841
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.22585942
39Systemic lupus erythematosus_Homo sapiens_hsa053221.21594934
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.21311154
41Butanoate metabolism_Homo sapiens_hsa006501.18448651
42Epstein-Barr virus infection_Homo sapiens_hsa051691.18411731
43Herpes simplex infection_Homo sapiens_hsa051681.15960526
44Olfactory transduction_Homo sapiens_hsa047401.13914743
45Viral carcinogenesis_Homo sapiens_hsa052031.13853565
46Steroid hormone biosynthesis_Homo sapiens_hsa001401.13827070
47Tryptophan metabolism_Homo sapiens_hsa003801.10317951
48Transcriptional misregulation in cancer_Homo sapiens_hsa052021.08353875
49N-Glycan biosynthesis_Homo sapiens_hsa005101.07688449
50HTLV-I infection_Homo sapiens_hsa051661.05273202
51Retinol metabolism_Homo sapiens_hsa008301.02733128
52Drug metabolism - other enzymes_Homo sapiens_hsa009831.00725120
53Hippo signaling pathway_Homo sapiens_hsa043900.99516134
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.97775235
55Hedgehog signaling pathway_Homo sapiens_hsa043400.97424865
56Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.96552692
57Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.94398168
58Adherens junction_Homo sapiens_hsa045200.94130218
59Small cell lung cancer_Homo sapiens_hsa052220.92196317
60Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.91345227
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90477725
62Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.86354222
63TGF-beta signaling pathway_Homo sapiens_hsa043500.85252115
64NF-kappa B signaling pathway_Homo sapiens_hsa040640.85033545
65Purine metabolism_Homo sapiens_hsa002300.84946900
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.81861444
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80120029
68Primary immunodeficiency_Homo sapiens_hsa053400.80040687
69Chronic myeloid leukemia_Homo sapiens_hsa052200.78245664
70Wnt signaling pathway_Homo sapiens_hsa043100.76746754
71Notch signaling pathway_Homo sapiens_hsa043300.73650322
72Prostate cancer_Homo sapiens_hsa052150.73281732
73Pathways in cancer_Homo sapiens_hsa052000.69215689
74Measles_Homo sapiens_hsa051620.66940693
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.66808550
76Hepatitis B_Homo sapiens_hsa051610.65069792
77Intestinal immune network for IgA production_Homo sapiens_hsa046720.65032702
78Colorectal cancer_Homo sapiens_hsa052100.64506381
79Protein export_Homo sapiens_hsa030600.62113789
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61761309
81Hematopoietic cell lineage_Homo sapiens_hsa046400.61534509
82Alcoholism_Homo sapiens_hsa050340.60794049
83Metabolic pathways_Homo sapiens_hsa011000.59023639
84Glutathione metabolism_Homo sapiens_hsa004800.59000663
85NOD-like receptor signaling pathway_Homo sapiens_hsa046210.58596246
86Phototransduction_Homo sapiens_hsa047440.57204886
87Apoptosis_Homo sapiens_hsa042100.56546533
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55745292
89Non-small cell lung cancer_Homo sapiens_hsa052230.54734997
90Melanoma_Homo sapiens_hsa052180.54458079
91Shigellosis_Homo sapiens_hsa051310.54426069
92Pancreatic cancer_Homo sapiens_hsa052120.53969950
93Bladder cancer_Homo sapiens_hsa052190.53644054
94Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.52752614
95Arachidonic acid metabolism_Homo sapiens_hsa005900.51510464
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50392909
97Huntingtons disease_Homo sapiens_hsa050160.49216865
98Thyroid cancer_Homo sapiens_hsa052160.48372563
99Nitrogen metabolism_Homo sapiens_hsa009100.48094400
100Sphingolipid metabolism_Homo sapiens_hsa006000.47282892
101Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.47258892
102Antigen processing and presentation_Homo sapiens_hsa046120.46024480
103Autoimmune thyroid disease_Homo sapiens_hsa053200.45989610
104Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.45567147
105Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.45467441
106Proteoglycans in cancer_Homo sapiens_hsa052050.44988301
107Viral myocarditis_Homo sapiens_hsa054160.44262293
108Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43100838
109FoxO signaling pathway_Homo sapiens_hsa040680.42971983
110Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42733304
111Oxidative phosphorylation_Homo sapiens_hsa001900.41500031
112Axon guidance_Homo sapiens_hsa043600.40986546
113Tight junction_Homo sapiens_hsa045300.40841439
114Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.40576977
115Leukocyte transendothelial migration_Homo sapiens_hsa046700.40039112
116Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38905634
117Linoleic acid metabolism_Homo sapiens_hsa005910.38742358
118Maturity onset diabetes of the young_Homo sapiens_hsa049500.38130089
119Graft-versus-host disease_Homo sapiens_hsa053320.37704792
120ErbB signaling pathway_Homo sapiens_hsa040120.36404231
121mTOR signaling pathway_Homo sapiens_hsa041500.36305213
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.36042219
123Influenza A_Homo sapiens_hsa051640.35839262
124Parkinsons disease_Homo sapiens_hsa050120.35444805
125Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.34536340
126Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.33673549
127T cell receptor signaling pathway_Homo sapiens_hsa046600.33371340
128Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32778008
129Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.32679560
130Steroid biosynthesis_Homo sapiens_hsa001000.31937569
131Renal cell carcinoma_Homo sapiens_hsa052110.31184228
132Endometrial cancer_Homo sapiens_hsa052130.30622510
133Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.29357082
134Malaria_Homo sapiens_hsa051440.29282965
135Acute myeloid leukemia_Homo sapiens_hsa052210.28659629
136Lysine degradation_Homo sapiens_hsa003100.28573628
137RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.28260060
138Leishmaniasis_Homo sapiens_hsa051400.28206409
139Renin-angiotensin system_Homo sapiens_hsa046140.27998807
140Sulfur relay system_Homo sapiens_hsa041220.27904826
141ECM-receptor interaction_Homo sapiens_hsa045120.27611354
142B cell receptor signaling pathway_Homo sapiens_hsa046620.26744550
143Allograft rejection_Homo sapiens_hsa053300.26704117
144Ether lipid metabolism_Homo sapiens_hsa005650.26677183
145Fatty acid metabolism_Homo sapiens_hsa012120.25881212
146Taste transduction_Homo sapiens_hsa047420.23967088
147Biosynthesis of amino acids_Homo sapiens_hsa012300.21782955
148Vitamin digestion and absorption_Homo sapiens_hsa049770.17897885
149Folate biosynthesis_Homo sapiens_hsa007900.16888531
150Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.15362886
151Starch and sucrose metabolism_Homo sapiens_hsa005000.14905524
152Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.14770569
153Chemical carcinogenesis_Homo sapiens_hsa052040.13870549
154Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.12951263
155Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.10058827
156alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.09903163

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