PRR13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)5.11923191
2negative regulation of cell killing (GO:0031342)4.50823116
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.50823116
4leukocyte aggregation (GO:0070486)4.09167008
5cellular response to zinc ion (GO:0071294)4.08548920
6cytidine metabolic process (GO:0046087)3.96052151
7cytidine catabolic process (GO:0006216)3.96052151
8cytidine deamination (GO:0009972)3.96052151
9response to peptidoglycan (GO:0032494)3.95280591
10Arp2/3 complex-mediated actin nucleation (GO:0034314)3.92719538
11sequestering of actin monomers (GO:0042989)3.88489827
12immunoglobulin mediated immune response (GO:0016064)3.88100232
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.85602971
14respiratory burst (GO:0045730)3.78361779
15production of molecular mediator involved in inflammatory response (GO:0002532)3.75609349
16neutrophil activation (GO:0042119)3.74704317
17granulocyte activation (GO:0036230)3.71496512
18antigen processing and presentation of endogenous antigen (GO:0019883)3.65716750
19positive regulation of B cell differentiation (GO:0045579)3.44547346
20pyrimidine ribonucleoside catabolic process (GO:0046133)3.42514998
21regulation of B cell receptor signaling pathway (GO:0050855)3.36143647
22positive regulation of mast cell activation (GO:0033005)3.36046700
23antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.33534205
24antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.33534205
25regulation of gamma-delta T cell activation (GO:0046643)3.31859176
26regulation of gamma-delta T cell differentiation (GO:0045586)3.29488346
27interferon-gamma-mediated signaling pathway (GO:0060333)3.22713169
28positive regulation of interferon-alpha production (GO:0032727)3.21591913
29type I interferon signaling pathway (GO:0060337)3.21321882
30cellular response to type I interferon (GO:0071357)3.21321882
31positive regulation of T cell mediated cytotoxicity (GO:0001916)3.20320687
32response to type I interferon (GO:0034340)3.19174300
33antigen processing and presentation via MHC class Ib (GO:0002475)3.18439622
34positive regulation of antigen processing and presentation (GO:0002579)3.17067861
35positive regulation of gamma-delta T cell activation (GO:0046645)3.15668994
36regulation of T-helper 1 cell differentiation (GO:0045625)3.15659003
37cellular extravasation (GO:0045123)3.15434590
38actin nucleation (GO:0045010)3.11275875
39B cell mediated immunity (GO:0019724)3.10616242
40positive regulation of mast cell degranulation (GO:0043306)3.05066780
41positive regulation of mast cell activation involved in immune response (GO:0033008)3.05066780
42regulation of interferon-alpha production (GO:0032647)3.05057798
43regulation of T cell mediated cytotoxicity (GO:0001914)3.04153750
44leukocyte cell-cell adhesion (GO:0007159)3.02399289
45positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.02109121
46regulation of RIG-I signaling pathway (GO:0039535)2.97509744
47positive thymic T cell selection (GO:0045059)2.97359788
48regulation of dendritic cell antigen processing and presentation (GO:0002604)2.97256619
49positive regulation of alpha-beta T cell proliferation (GO:0046641)2.95986687
50positive regulation of interferon-beta production (GO:0032728)2.94198242
51NIK/NF-kappaB signaling (GO:0038061)2.93111494
52cellular response to interleukin-15 (GO:0071350)2.92912462
53hydrogen peroxide biosynthetic process (GO:0050665)2.92732622
54defense response to protozoan (GO:0042832)2.92477822
55negative T cell selection (GO:0043383)2.91176119
56positive regulation of protein homooligomerization (GO:0032464)2.89619273
57lipopolysaccharide-mediated signaling pathway (GO:0031663)2.88406762
58positive regulation by symbiont of host defense response (GO:0052509)2.87898056
59modulation by symbiont of host defense response (GO:0052031)2.87898056
60modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.87898056
61modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.87898056
62positive regulation by organism of defense response of other organism involved in symbiotic interact2.87898056
63modulation by symbiont of host immune response (GO:0052553)2.87898056
64natural killer cell mediated cytotoxicity (GO:0042267)2.87610209
65natural killer cell mediated immunity (GO:0002228)2.87610209
66regulation of mast cell degranulation (GO:0043304)2.87296061
67regulation of mast cell activation (GO:0033003)2.86962923
68negative thymic T cell selection (GO:0045060)2.86389672
69response to interleukin-15 (GO:0070672)2.84950700
70macrophage activation involved in immune response (GO:0002281)2.84894454
71response to interferon-beta (GO:0035456)2.84649813
72regulation of activation of Janus kinase activity (GO:0010533)2.84311529
73regulation of T cell tolerance induction (GO:0002664)2.84112414
74regulation of cellular extravasation (GO:0002691)2.83363966
75response to protozoan (GO:0001562)2.81733123
76regulation of antigen processing and presentation (GO:0002577)2.81621016
77myeloid dendritic cell activation (GO:0001773)2.81208797
78cellular response to interferon-beta (GO:0035458)2.77959476
79leukocyte mediated cytotoxicity (GO:0001909)2.76733182
80detection of other organism (GO:0098543)2.75856038
81lipoxygenase pathway (GO:0019372)2.75525368
82T cell migration (GO:0072678)2.73554536
83negative regulation of interleukin-12 production (GO:0032695)2.73368826
84regulation of B cell differentiation (GO:0045577)2.72844033
85regulation of alpha-beta T cell proliferation (GO:0046640)2.72048240
86myeloid cell activation involved in immune response (GO:0002275)2.70976718
87T-helper 1 type immune response (GO:0042088)2.70570034
88positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.69935429
89myeloid dendritic cell differentiation (GO:0043011)2.69771666
90regulation of regulatory T cell differentiation (GO:0045589)2.69275112
91positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.68235323
92regulation of integrin activation (GO:0033623)2.67042693
93negative regulation of viral genome replication (GO:0045071)2.66780904
94antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.66372638
95positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.66216633
96regulation of mast cell activation involved in immune response (GO:0033006)2.65277758
97leukocyte degranulation (GO:0043299)2.65079683
98negative regulation of leukocyte mediated immunity (GO:0002704)2.65049228
99regulation of leukocyte mediated cytotoxicity (GO:0001910)2.65001814
100negative regulation of lymphocyte mediated immunity (GO:0002707)2.64953063
101superoxide anion generation (GO:0042554)2.64222282
102regulation of natural killer cell mediated immunity (GO:0002715)2.62639280
103regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.62639280
104B cell receptor signaling pathway (GO:0050853)2.62612171
105DNA deamination (GO:0045006)2.62479156
106regulation of tolerance induction (GO:0002643)2.62155470
107reactive oxygen species biosynthetic process (GO:1903409)2.61035661
108negative regulation of phagocytosis (GO:0050765)2.60598987
109detection of bacterium (GO:0016045)2.60316027
110regulation of interferon-beta biosynthetic process (GO:0045357)2.60199812
111regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.59731172
112regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.59615841
113positive regulation of macrophage differentiation (GO:0045651)2.58938153
114negative regulation of nitric oxide biosynthetic process (GO:0045019)2.58528302
115regulation of mononuclear cell migration (GO:0071675)2.58286223
116regulation of response to interferon-gamma (GO:0060330)2.56565675
117regulation of superoxide anion generation (GO:0032928)2.56380756
118positive regulation of chemokine biosynthetic process (GO:0045080)2.56276316
119response to muramyl dipeptide (GO:0032495)2.55969273
120positive regulation of T-helper cell differentiation (GO:0045624)2.55915488
121angiotensin maturation (GO:0002003)2.55342871
122positive regulation of isotype switching (GO:0045830)2.55313557
123T cell costimulation (GO:0031295)2.54488648
124dendritic cell chemotaxis (GO:0002407)2.54408789
125thymic T cell selection (GO:0045061)2.53215651
126antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.52306374
127positive regulation of lamellipodium assembly (GO:0010592)2.52093912
128regulation of podosome assembly (GO:0071801)2.50676917
129endosome to pigment granule transport (GO:0043485)2.50472876
130endosome to melanosome transport (GO:0035646)2.50472876
131lymphocyte costimulation (GO:0031294)2.50466136
132regulation of T-helper 2 cell differentiation (GO:0045628)2.50352826
133response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.50023970
134response to host immune response (GO:0052572)2.50023970
135positive regulation of monocyte chemotaxis (GO:0090026)2.49927084
136positive regulation of type 2 immune response (GO:0002830)2.49899298
137positive regulation of interleukin-17 production (GO:0032740)2.49261581
138regulation of myeloid leukocyte mediated immunity (GO:0002886)2.49104725
139positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.48753482
140negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.45421067
141tolerance induction (GO:0002507)2.45345073
142negative regulation of innate immune response (GO:0045824)2.44942501
143T cell selection (GO:0045058)2.44279561
144mast cell activation (GO:0045576)2.44213569
145detection of external biotic stimulus (GO:0098581)2.42195145
146antigen receptor-mediated signaling pathway (GO:0050851)2.42093051

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.15754158
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.81672852
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.66643157
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.39729309
5* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.91686406
6* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.78598903
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.66591124
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.66250721
9IRF8_27001747_Chip-Seq_BMDM_Mouse2.60384546
10MYB_21317192_ChIP-Seq_ERMYB_Mouse2.60206833
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.54598972
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.49687598
13* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.41678219
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.35368223
15NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.34828217
16STAT4_19710469_ChIP-ChIP_TH1__Mouse2.34237467
17RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.28632777
18SPI1_23547873_ChIP-Seq_NB4_Human2.27434597
19* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.21394336
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.11424407
21* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.95787080
22EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.95055200
23TP63_17297297_ChIP-ChIP_HaCaT_Human1.91043116
24STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.90099737
25* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.76547549
26EGR1_19374776_ChIP-ChIP_THP-1_Human1.74248072
27BRD4_27068464_Chip-Seq_AML-cells_Mouse1.71762700
28VDR_21846776_ChIP-Seq_THP-1_Human1.70474144
29STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.68156312
30MYB_26560356_Chip-Seq_TH2_Human1.67716972
31GABP_17652178_ChIP-ChIP_JURKAT_Human1.67609535
32ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.67080314
33MAF_26560356_Chip-Seq_TH1_Human1.66047628
34* RUNX1_22412390_ChIP-Seq_EML_Mouse1.65454692
35ELF1_17652178_ChIP-ChIP_JURKAT_Human1.62805893
36CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.57870755
37PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.55089514
38VDR_24763502_ChIP-Seq_THP-1_Human1.54015228
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.51184659
40* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.46527813
41CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.46489887
42MYB_26560356_Chip-Seq_TH1_Human1.44501287
43* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.43753760
44HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.42039950
45JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.40936174
46* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.40782464
47PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.39674651
48* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.36359526
49CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.33735299
50* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32215795
51* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.31548638
52GATA2_22383799_ChIP-Seq_G1ME_Mouse1.29032829
53FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.28913954
54* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.28849227
55LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.28339183
56LXR_22292898_ChIP-Seq_THP-1_Human1.27507208
57HOXB4_20404135_ChIP-ChIP_EML_Mouse1.26782805
58GATA1_22383799_ChIP-Seq_G1ME_Mouse1.26400880
59SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26165130
60UTX_26944678_Chip-Seq_JUKART_Human1.26138223
61* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.25888659
62PU_27001747_Chip-Seq_BMDM_Mouse1.25426584
63VDR_23849224_ChIP-Seq_CD4+_Human1.23154782
64MAF_26560356_Chip-Seq_TH2_Human1.22478225
65PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21997167
66TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21655673
67SPI1_23127762_ChIP-Seq_K562_Human1.18710511
68EST1_17652178_ChIP-ChIP_JURKAT_Human1.17707405
69ELF1_20517297_ChIP-Seq_JURKAT_Human1.16811058
70GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.16737915
71CREB1_15753290_ChIP-ChIP_HEK293T_Human1.16307031
72MYC_22102868_ChIP-Seq_BL_Human1.15735663
73ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.13963221
74ELK3_25401928_ChIP-Seq_HUVEC_Human1.13917128
75CIITA_25753668_ChIP-Seq_RAJI_Human1.13842143
76THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.12817195
77* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11757872
78ETS1_20019798_ChIP-Seq_JURKAT_Human1.11460093
79E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.11314654
80NOTCH1_21737748_ChIP-Seq_TLL_Human1.09871727
81FOXP3_21729870_ChIP-Seq_TREG_Human1.09777382
82TFEB_21752829_ChIP-Seq_HELA_Human1.09460651
83LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.06942173
84PPARA_22158963_ChIP-Seq_LIVER_Mouse1.05283216
85RUNX_20019798_ChIP-Seq_JUKART_Human1.05278007
86NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.04680923
87STAT3_1855785_ChIP-Seq_MESCs_Mouse1.04275610
88SRF_21415370_ChIP-Seq_HL-1_Mouse1.03995553
89SCL_19346495_ChIP-Seq_HPC-7_Human1.03522726
90STAT1_20625510_ChIP-Seq_HELA_Human1.03498538
91* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.03199959
92ERG_20887958_ChIP-Seq_HPC-7_Mouse1.02182503
93RARG_19884340_ChIP-ChIP_MEFs_Mouse1.01822332
94TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.00973847
95KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.00944037
96E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.00657301
97P300_27268052_Chip-Seq_Bcells_Human1.00382193
98GATA3_27048872_Chip-Seq_THYMUS_Human1.00342053
99PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.00279177
100CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.98895879
101MYC_18358816_ChIP-ChIP_MESCs_Mouse0.97115191
102TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.96700238
103P68_20966046_ChIP-Seq_HELA_Human0.96447125
104BCL6_27268052_Chip-Seq_Bcells_Human0.95991437
105STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.95266026
106* TET1_21451524_ChIP-Seq_MESCs_Mouse0.94727783
107GATA3_26560356_Chip-Seq_TH2_Human0.94328077
108E2F1_20622854_ChIP-Seq_HELA_Human0.94163524
109ELK1_22589737_ChIP-Seq_MCF10A_Human0.94152756
110NCOR1_26117541_ChIP-Seq_K562_Human0.94120473
111ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.93511211
112HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.93299426
113E2F7_22180533_ChIP-Seq_HELA_Human0.93072250
114CTCF_27219007_Chip-Seq_ERYTHROID_Human0.92601598
115* SA1_27219007_Chip-Seq_Bcells_Human0.92056449
116DCP1A_22483619_ChIP-Seq_HELA_Human0.91856850
117E2F1_18555785_ChIP-Seq_MESCs_Mouse0.90852310
118NANOG_18555785_ChIP-Seq_MESCs_Mouse0.89145379
119* ELK1_19687146_ChIP-ChIP_HELA_Human0.86560259
120GABP_19822575_ChIP-Seq_HepG2_Human0.86446609
121BCOR_27268052_Chip-Seq_Bcells_Human0.85439449
122MYC_18555785_ChIP-Seq_MESCs_Mouse0.84589096
123SRY_22984422_ChIP-ChIP_TESTIS_Rat0.83296493
124CTCF_26484167_Chip-Seq_Bcells_Mouse0.82830354
125FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.82652385

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.17993948
2MP0009785_altered_susceptibility_to3.60251910
3MP0003436_decreased_susceptibility_to3.52183187
4MP0002148_abnormal_hypersensitivity_rea3.36194986
5MP0005671_abnormal_response_to3.22731999
6MP0000685_abnormal_immune_system3.18130405
7MP0005000_abnormal_immune_tolerance2.86751406
8MP0005025_abnormal_response_to2.80411178
9MP0006082_CNS_inflammation2.72722423
10MP0003724_increased_susceptibility_to2.68864163
11MP0002419_abnormal_innate_immunity2.68342881
12MP0001790_abnormal_immune_system2.66195538
13MP0005387_immune_system_phenotype2.66195538
14MP0002452_abnormal_antigen_presenting2.49499494
15MP0001800_abnormal_humoral_immune2.49351701
16MP0002723_abnormal_immune_serum2.40665629
17MP0003806_abnormal_nucleotide_metabolis2.39236936
18MP0001819_abnormal_immune_cell2.32531982
19MP0002420_abnormal_adaptive_immunity2.29969129
20MP0009278_abnormal_bone_marrow2.28076938
21MP0005058_abnormal_lysosome_morphology2.26670469
22MP0005397_hematopoietic_system_phenotyp2.24192040
23MP0001545_abnormal_hematopoietic_system2.24192040
24MP0009333_abnormal_splenocyte_physiolog2.21969294
25MP0002405_respiratory_system_inflammati2.20053019
26MP0005360_urolithiasis2.16766230
27MP0005464_abnormal_platelet_physiology2.03788736
28MP0010155_abnormal_intestine_physiology1.99757771
29MP0001845_abnormal_inflammatory_respons1.88416475
30MP0001853_heart_inflammation1.87875430
31MP0002398_abnormal_bone_marrow1.84733541
32MP0003303_peritoneal_inflammation1.81698457
33MP0000716_abnormal_immune_system1.80648871
34MP0001533_abnormal_skeleton_physiology1.76472585
35MP0003763_abnormal_thymus_physiology1.74505679
36MP0004510_myositis1.73418607
37MP0002006_tumorigenesis1.72336578
38MP0004947_skin_inflammation1.71566208
39MP0000858_altered_metastatic_potential1.69182903
40MP0002166_altered_tumor_susceptibility1.66025993
41MP0005310_abnormal_salivary_gland1.65261712
42MP0000689_abnormal_spleen_morphology1.56766863
43MP0009764_decreased_sensitivity_to1.55333028
44MP0003448_altered_tumor_morphology1.52843455
45MP0002429_abnormal_blood_cell1.52801386
46MP0000343_altered_response_to1.52769796
47MP0002722_abnormal_immune_system1.51389883
48MP0000490_abnormal_crypts_of1.50683515
49MP0008469_abnormal_protein_level1.45716876
50MP0003693_abnormal_embryo_hatching1.41387200
51MP0002138_abnormal_hepatobiliary_system1.39684473
52MP0001873_stomach_inflammation1.38512079
53MP0003866_abnormal_defecation1.37320780
54MP0002139_abnormal_hepatobiliary_system1.37061861
55MP0002132_abnormal_respiratory_system1.34988712
56MP0002277_abnormal_respiratory_mucosa1.34250930
57MP0003186_abnormal_redox_activity1.34049346
58MP0005085_abnormal_gallbladder_physiolo1.31029042
59MP0005451_abnormal_body_composition1.27858331
60MP0008260_abnormal_autophagy1.26695184
61MP0003656_abnormal_erythrocyte_physiolo1.25585316
62MP0002396_abnormal_hematopoietic_system1.24787936
63MP0009379_abnormal_foot_pigmentation1.18801628
64MP0009840_abnormal_foam_cell1.14676986
65MP0002933_joint_inflammation1.14009896
66MP0003453_abnormal_keratinocyte_physiol1.12276668
67MP0003191_abnormal_cellular_cholesterol1.03519822
68MP0003075_altered_response_to1.03413222
69MP0002254_reproductive_system_inflammat1.03395644
70MP0004808_abnormal_hematopoietic_stem1.02695582
71MP0005365_abnormal_bile_salt1.02108698
72MP0000465_gastrointestinal_hemorrhage1.01994526
73MP0010352_gastrointestinal_tract_polyps0.99669277
74MP0003566_abnormal_cell_adhesion0.98296534
75MP0001666_abnormal_nutrient_absorption0.97907459
76MP0002019_abnormal_tumor_incidence0.93862470
77MP0005390_skeleton_phenotype0.93614716
78MP0002998_abnormal_bone_remodeling0.92203999
79MP0004264_abnormal_extraembryonic_tissu0.91992608
80MP0004019_abnormal_vitamin_homeostasis0.91985515
81MP0005166_decreased_susceptibility_to0.91724270
82MP0009643_abnormal_urine_homeostasis0.90855241
83MP0002163_abnormal_gland_morphology0.90577396
84MP0001986_abnormal_taste_sensitivity0.89853494
85MP0004782_abnormal_surfactant_physiolog0.89524780
86MP0008057_abnormal_DNA_replication0.88796670
87MP0004147_increased_porphyrin_level0.88438792
88MP0005319_abnormal_enzyme/_coenzyme0.88412332
89MP0003828_pulmonary_edema0.88054612
90MP0000703_abnormal_thymus_morphology0.86562668
91MP0005174_abnormal_tail_pigmentation0.86041509
92MP0003172_abnormal_lysosome_physiology0.85874551
93MP0001348_abnormal_lacrimal_gland0.84713240
94MP0010307_abnormal_tumor_latency0.84543495
95MP0001542_abnormal_bone_strength0.84202453
96MP0008004_abnormal_stomach_pH0.84048269
97MP0009765_abnormal_xenobiotic_induced0.83111862
98MP0005023_abnormal_wound_healing0.83099098
99MP0006036_abnormal_mitochondrial_physio0.82927787
100MP0003183_abnormal_peptide_metabolism0.80848290
101MP0000609_abnormal_liver_physiology0.79333021
102MP0005636_abnormal_mineral_homeostasis0.78546510
103MP0001765_abnormal_ion_homeostasis0.77804899
104MP0002877_abnormal_melanocyte_morpholog0.77665709
105MP0005584_abnormal_enzyme/coenzyme_acti0.74545192
106MP0005381_digestive/alimentary_phenotyp0.71317750
107MP0003300_gastrointestinal_ulcer0.69331006
108MP0002009_preneoplasia0.69285333
109MP0003252_abnormal_bile_duct0.68945533
110MP0005075_abnormal_melanosome_morpholog0.66794344
111MP0005083_abnormal_biliary_tract0.66024937
112MP0005164_abnormal_response_to0.64509617
113MP0010234_abnormal_vibrissa_follicle0.64110134
114MP0005076_abnormal_cell_differentiation0.63823966
115MP0000604_amyloidosis0.63503850
116MP0005165_increased_susceptibility_to0.62783386
117MP0004957_abnormal_blastocyst_morpholog0.62572818
118MP0009763_increased_sensitivity_to0.61783217
119MP0001663_abnormal_digestive_system0.60651212
120MP0002136_abnormal_kidney_physiology0.60024173
121MP0003786_premature_aging0.60011974
122MP0001851_eye_inflammation0.59876878
123MP0001764_abnormal_homeostasis0.59357839
124MP0000249_abnormal_blood_vessel0.57398950
125MP0000371_diluted_coat_color0.57055241
126MP0000477_abnormal_intestine_morphology0.55683989
127MP0000313_abnormal_cell_death0.54912720

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.35767061
2Eczematoid dermatitis (HP:0000976)6.10924291
3Recurrent bacterial skin infections (HP:0005406)5.50476305
4Pustule (HP:0200039)5.10642980
5Increased IgM level (HP:0003496)4.59096259
6Recurrent gram-negative bacterial infections (HP:0005420)4.43264591
7Myositis (HP:0100614)4.35785390
8Abnormality of macrophages (HP:0004311)4.27781646
9Elevated erythrocyte sedimentation rate (HP:0003565)4.20419921
10Vacuolated lymphocytes (HP:0001922)4.09201303
11Autoimmune thrombocytopenia (HP:0001973)4.08074693
12Recurrent fungal infections (HP:0002841)3.89096448
13Orchitis (HP:0100796)3.70445806
14Chronic obstructive pulmonary disease (HP:0006510)3.70086804
15Obstructive lung disease (HP:0006536)3.70086804
16Mediastinal lymphadenopathy (HP:0100721)3.65282291
17Petechiae (HP:0000967)3.55154995
18Optic neuritis (HP:0100653)3.40581218
19Retrobulbar optic neuritis (HP:0100654)3.40581218
20Recurrent skin infections (HP:0001581)3.36810111
21Gingivitis (HP:0000230)3.26017017
22Stomatitis (HP:0010280)3.20833434
23Vasculitis (HP:0002633)3.14873123
24Chronic diarrhea (HP:0002028)3.10680280
25Agammaglobulinemia (HP:0004432)3.02197479
26Interstitial pulmonary disease (HP:0006530)2.88859526
27Hypergammaglobulinemia (HP:0010702)2.85510165
28Aplastic anemia (HP:0001915)2.84590463
29Urticaria (HP:0001025)2.75511570
30Meningitis (HP:0001287)2.74963277
31Systemic lupus erythematosus (HP:0002725)2.74387064
32Dysostosis multiplex (HP:0000943)2.72558285
33Spontaneous hematomas (HP:0007420)2.72109827
34Cellulitis (HP:0100658)2.69667582
35Abnormality of T cell physiology (HP:0011840)2.67578551
36IgM deficiency (HP:0002850)2.66887381
37Cheilitis (HP:0100825)2.65448016
38IgG deficiency (HP:0004315)2.61222962
39Poor head control (HP:0002421)2.59527376
40Panhypogammaglobulinemia (HP:0003139)2.59334358
41Recurrent viral infections (HP:0004429)2.57971763
42Increased neuronal autofluorescent lipopigment (HP:0002074)2.55127426
43Abnormality of T cells (HP:0002843)2.53746909
44Anorexia (HP:0002039)2.52509702
45Hepatosplenomegaly (HP:0001433)2.50685248
46IgA deficiency (HP:0002720)2.48712029
47Malnutrition (HP:0004395)2.46848750
48Vertebral compression fractures (HP:0002953)2.46171343
49Leukocytosis (HP:0001974)2.45134728
50Recurrent cutaneous fungal infections (HP:0011370)2.43996774
51Chronic mucocutaneous candidiasis (HP:0002728)2.43996774
52Prostate neoplasm (HP:0100787)2.42375671
53Abnormality of T cell number (HP:0011839)2.41027039
54Basal ganglia calcification (HP:0002135)2.40866963
55Increased cerebral lipofuscin (HP:0011813)2.40156207
56Increased serum ferritin (HP:0003281)2.39605360
57Chronic otitis media (HP:0000389)2.38543273
58Skin rash (HP:0000988)2.37102445
59Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.30277532
60Purpura (HP:0000979)2.29955647
61Inflammation of the large intestine (HP:0002037)2.29832172
62Periodontitis (HP:0000704)2.28974744
63Gastrointestinal inflammation (HP:0004386)2.28927414
64Recurrent bronchitis (HP:0002837)2.27404388
65Mucopolysacchariduria (HP:0008155)2.25651591
66Urinary glycosaminoglycan excretion (HP:0003541)2.25651591
67Abnormality of the nasal mucosa (HP:0000433)2.25545763
68Chest pain (HP:0100749)2.25455938
69Recurrent pneumonia (HP:0006532)2.24951538
70Recurrent lower respiratory tract infections (HP:0002783)2.24796091
71Abnormality of glutamine family amino acid metabolism (HP:0010902)2.22491009
72Hemoptysis (HP:0002105)2.21645825
73Pulmonary infiltrates (HP:0002113)2.21361760
74Abnormal delayed hypersensitivity skin test (HP:0002963)2.19057752
75Abnormality of iron homeostasis (HP:0011031)2.18533749
76Thrombocytosis (HP:0001894)2.18514237
77Abnormality of B cell number (HP:0010975)2.17385094
78Joint swelling (HP:0001386)2.17124062
79Gastrointestinal infarctions (HP:0005244)2.17021349
80Arterial thrombosis (HP:0004420)2.14635116
81Encephalitis (HP:0002383)2.12063771
82Nasal polyposis (HP:0100582)2.11584793
83Skin ulcer (HP:0200042)2.10569742
84Osteomyelitis (HP:0002754)2.09534588
85Increased IgE level (HP:0003212)2.07595315
86Abnormality of mucopolysaccharide metabolism (HP:0011020)2.07249030
87Abnormality of polysaccharide metabolism (HP:0011012)2.07249030
88Abnormality of glycosaminoglycan metabolism (HP:0004371)2.07249030
89T lymphocytopenia (HP:0005403)2.06573835
90Abnormality of glycolipid metabolism (HP:0010969)2.05391987
91Abnormality of liposaccharide metabolism (HP:0010968)2.05391987
92Abnormality of glycosphingolipid metabolism (HP:0004343)2.05391987
93Abnormality of eosinophils (HP:0001879)2.04620406
94Abnormality of cells of the lymphoid lineage (HP:0012140)2.04334103
95Eosinophilia (HP:0001880)2.02484837
96Exertional dyspnea (HP:0002875)2.02481681
97Tongue fasciculations (HP:0001308)2.02467569
98Hypertensive crisis (HP:0100735)2.02400046
99Keratoconjunctivitis sicca (HP:0001097)2.00764215
100Loss of speech (HP:0002371)2.00689723
101Combined immunodeficiency (HP:0005387)2.00028714
102Prolonged bleeding time (HP:0003010)1.99414478
103Hypochromic anemia (HP:0001931)1.98948249
104Poikiloderma (HP:0001029)1.98158514
105Lymphopenia (HP:0001888)1.96828836
106Epistaxis (HP:0000421)1.96551561
107Colitis (HP:0002583)1.96537490
108Polycythemia (HP:0001901)1.95933541
109Alopecia of scalp (HP:0002293)1.95383374
110Abnormality of the prostate (HP:0008775)1.94955693
111Axonal loss (HP:0003447)1.92355984
112Sepsis (HP:0100806)1.92157757
113Granulocytopenia (HP:0001913)1.91144307
114Abnormality of the pleura (HP:0002103)1.90003275
115Autoimmune hemolytic anemia (HP:0001890)1.89479305
116Gastrointestinal stroma tumor (HP:0100723)1.89353564
117Gingival bleeding (HP:0000225)1.89288900
118Gangrene (HP:0100758)1.89249084
119Episodic fever (HP:0001954)1.88964478
120Keratoconjunctivitis (HP:0001096)1.88282351
121Abnormality of male internal genitalia (HP:0000022)1.85977408
122Nausea (HP:0002018)1.85501031
123Ileus (HP:0002595)1.84729774
124Severe combined immunodeficiency (HP:0004430)1.84689296
125Acute hepatic failure (HP:0006554)1.84591042

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PIM23.88132558
2BLK3.46251212
3MAP4K13.18096097
4MAP3K143.02178043
5TBK12.82576307
6IRAK42.76805577
7TXK2.75330904
8IRAK32.35984785
9NME22.30144725
10RIPK42.29583906
11ZAP702.22919012
12MAP3K122.21609009
13IKBKB2.02314551
14VRK22.01779749
15IKBKE2.01076516
16TYK22.00201978
17JAK31.97103412
18MAP3K111.97087804
19MATK1.96308902
20FES1.95698854
21CSK1.94482621
22MST41.89921251
23PIM11.78683640
24ERN11.74490445
25TEC1.69588940
26STK101.60221848
27TESK21.59535576
28TESK11.55659886
29BTK1.46340725
30KIT1.39511883
31ARAF1.36930134
32TNK21.33559195
33TRPM71.33235141
34BCKDK1.32035563
35SYK1.23827931
36CHUK1.20025835
37RPS6KA41.18701681
38TAOK31.16412618
39PBK1.12319189
40EIF2AK11.11119283
41NEK91.10484159
42PRPF4B1.09359763
43LYN1.09298995
44SIK31.07704060
45FGR1.07157839
46JAK11.07153327
47KDR1.05978557
48MAP2K31.01191517
49BMX0.99184368
50TAOK20.96908859
51LCK0.96606511
52ACVR1B0.96208642
53SMG10.95072269
54MARK30.94511864
55SCYL20.91574389
56PRKCQ0.90268852
57STK160.88558794
58ITK0.85329938
59PASK0.85054316
60STK240.83742657
61EPHB10.83443487
62LRRK20.83350954
63HCK0.80587454
64YES10.79496876
65MAPKAPK20.78603295
66PDK20.77085599
67MYLK0.74762198
68BUB10.74166585
69ABL20.73656513
70PRKG20.71802567
71EIF2AK30.70023638
72MAP3K30.68523700
73CDK190.67771165
74LIMK10.67510704
75RPS6KA60.66397253
76FGFR40.65924978
77PRKCD0.64218999
78TGFBR20.63001010
79JAK20.62365833
80PDK10.61778745
81PTK60.61736292
82GRK70.61224496
83NLK0.60900503
84EPHA30.60135751
85GRK60.56728237
86CSF1R0.56332397
87RPS6KL10.56207159
88RPS6KC10.56207159
89MST1R0.55804582
90MAPKAPK30.52814196
91PDPK10.51159156
92PINK10.49559648
93EIF2AK20.47595113
94PLK40.46868900
95MAP2K60.45936954
96DYRK1B0.44892212
97ERBB30.44804219
98DAPK10.44325754
99MAP3K60.44149107
100PAK40.43953605
101BMPR20.43191498
102EPHA20.42942016
103FGFR30.42854223
104FYN0.42687347
105PAK10.42632545
106RPS6KB20.42449994
107STK40.41229915
108CDK60.39362520
109ILK0.39189638
110MAPK150.38932474
111OXSR10.38544338
112MAP2K20.38324269
113ABL10.37514310
114CDK70.34413844
115MAP3K80.33612230
116MAPK110.33149908
117IRAK10.31565139
118ALK0.31234730
119GRK50.29922340
120TLK10.29611349
121DDR20.29500265
122TAOK10.29333194
123TRIB30.29259865
124MAP3K130.28961605
125MAP3K10.28954836
126NUAK10.28353083
127CLK10.28144265
128CDK40.26954573
129KSR20.26590405

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053322.84232469
2Leishmaniasis_Homo sapiens_hsa051402.78737985
3Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.76196896
4Allograft rejection_Homo sapiens_hsa053302.66966857
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.54442508
6Proteasome_Homo sapiens_hsa030502.43530364
7Legionellosis_Homo sapiens_hsa051342.19053005
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.15915247
9Primary immunodeficiency_Homo sapiens_hsa053402.13178367
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.03258769
11Measles_Homo sapiens_hsa051622.01999804
12RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.98164674
13Toll-like receptor signaling pathway_Homo sapiens_hsa046201.97816394
14Staphylococcus aureus infection_Homo sapiens_hsa051501.94305099
15NOD-like receptor signaling pathway_Homo sapiens_hsa046211.90189910
16Asthma_Homo sapiens_hsa053101.89174833
17Shigellosis_Homo sapiens_hsa051311.85910525
18Pertussis_Homo sapiens_hsa051331.75373886
19Rheumatoid arthritis_Homo sapiens_hsa053231.73026454
20Hematopoietic cell lineage_Homo sapiens_hsa046401.71541232
21Osteoclast differentiation_Homo sapiens_hsa043801.69642417
22Tuberculosis_Homo sapiens_hsa051521.66489117
23Salmonella infection_Homo sapiens_hsa051321.54316577
24Autoimmune thyroid disease_Homo sapiens_hsa053201.54131678
25Antigen processing and presentation_Homo sapiens_hsa046121.51101176
26Lysosome_Homo sapiens_hsa041421.49048055
27Malaria_Homo sapiens_hsa051441.48727870
28Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.45180233
29Herpes simplex infection_Homo sapiens_hsa051681.44414473
30Influenza A_Homo sapiens_hsa051641.43298832
31TNF signaling pathway_Homo sapiens_hsa046681.40641501
32Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.40504544
33Apoptosis_Homo sapiens_hsa042101.40066964
34Jak-STAT signaling pathway_Homo sapiens_hsa046301.39930179
35Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.34119212
36Type I diabetes mellitus_Homo sapiens_hsa049401.32260628
37Other glycan degradation_Homo sapiens_hsa005111.30187930
38Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.29202822
39Base excision repair_Homo sapiens_hsa034101.27496250
40Phagosome_Homo sapiens_hsa041451.25690511
41Toxoplasmosis_Homo sapiens_hsa051451.25110681
42Cyanoamino acid metabolism_Homo sapiens_hsa004601.22701917
43p53 signaling pathway_Homo sapiens_hsa041151.21524360
44RNA polymerase_Homo sapiens_hsa030201.18408694
45Ribosome_Homo sapiens_hsa030101.14690494
46Oxidative phosphorylation_Homo sapiens_hsa001901.13343280
47Viral myocarditis_Homo sapiens_hsa054161.13184915
48B cell receptor signaling pathway_Homo sapiens_hsa046621.12711691
49Vitamin digestion and absorption_Homo sapiens_hsa049771.11646619
50Epstein-Barr virus infection_Homo sapiens_hsa051691.09986973
51Chemokine signaling pathway_Homo sapiens_hsa040621.09970421
52Sulfur metabolism_Homo sapiens_hsa009201.09460555
53Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.07460625
54Hepatitis B_Homo sapiens_hsa051611.07458490
55Regulation of autophagy_Homo sapiens_hsa041401.00636025
56Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.99284872
57Fat digestion and absorption_Homo sapiens_hsa049750.98287866
58Drug metabolism - other enzymes_Homo sapiens_hsa009830.97457559
59Glycosaminoglycan degradation_Homo sapiens_hsa005310.95267071
60Leukocyte transendothelial migration_Homo sapiens_hsa046700.89906984
61Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.89448440
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88576318
63Parkinsons disease_Homo sapiens_hsa050120.86826009
64Pentose phosphate pathway_Homo sapiens_hsa000300.85922686
65DNA replication_Homo sapiens_hsa030300.85831997
66Acute myeloid leukemia_Homo sapiens_hsa052210.85742348
67Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.84546495
68Mismatch repair_Homo sapiens_hsa034300.83184796
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.82159913
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.81248337
71African trypanosomiasis_Homo sapiens_hsa051430.80055978
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79553188
73Hepatitis C_Homo sapiens_hsa051600.79430821
74T cell receptor signaling pathway_Homo sapiens_hsa046600.76627099
75Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.76418336
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72770487
77Pyrimidine metabolism_Homo sapiens_hsa002400.71857854
78Fructose and mannose metabolism_Homo sapiens_hsa000510.68711133
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63799806
80Homologous recombination_Homo sapiens_hsa034400.63065698
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62024966
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60428748
83Folate biosynthesis_Homo sapiens_hsa007900.59366848
84Mineral absorption_Homo sapiens_hsa049780.58193761
85Prolactin signaling pathway_Homo sapiens_hsa049170.56039394
86Collecting duct acid secretion_Homo sapiens_hsa049660.55990369
87Galactose metabolism_Homo sapiens_hsa000520.55603219
88Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52269828
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51886588
90Nucleotide excision repair_Homo sapiens_hsa034200.49427750
91Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49124160
92Chronic myeloid leukemia_Homo sapiens_hsa052200.47792803
93Chemical carcinogenesis_Homo sapiens_hsa052040.47718520
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47138963
95Arachidonic acid metabolism_Homo sapiens_hsa005900.46885825
96Pancreatic cancer_Homo sapiens_hsa052120.45811091
97Viral carcinogenesis_Homo sapiens_hsa052030.45592576
98Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.43812688
99Platelet activation_Homo sapiens_hsa046110.40792258
100Huntingtons disease_Homo sapiens_hsa050160.39076432
101Peroxisome_Homo sapiens_hsa041460.38865424
102Amoebiasis_Homo sapiens_hsa051460.37778096
103Caffeine metabolism_Homo sapiens_hsa002320.37632839
104Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37387882
105Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36922129
106Alzheimers disease_Homo sapiens_hsa050100.36782764
107Cell cycle_Homo sapiens_hsa041100.35537262
108Renin-angiotensin system_Homo sapiens_hsa046140.34512264
109Starch and sucrose metabolism_Homo sapiens_hsa005000.34228972
110Endocytosis_Homo sapiens_hsa041440.34176009
111Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33704520
112HIF-1 signaling pathway_Homo sapiens_hsa040660.32325492
113Glutathione metabolism_Homo sapiens_hsa004800.31773264
114Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.31130768
115HTLV-I infection_Homo sapiens_hsa051660.29967290
116VEGF signaling pathway_Homo sapiens_hsa043700.29757196
117alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29394611
118Basal transcription factors_Homo sapiens_hsa030220.29377487

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