ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein-cofactor linkage (GO:0018065)	5.79381545
2	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	5.57688727
3	positive regulation of natural killer cell mediated immunity (GO:0002717)	5.48339512
4	negative regulation of synaptic transmission, GABAergic (GO:0032229)	5.36108732
5	regulation of natural killer cell mediated immunity (GO:0002715)	4.81547797
6	regulation of natural killer cell mediated cytotoxicity (GO:0042269)	4.81547797
7	positive T cell selection (GO:0043368)	4.70703828
8	cytolysis (GO:0019835)	4.69590098
9	negative T cell selection (GO:0043383)	4.56710750
10	regulation of B cell receptor signaling pathway (GO:0050855)	4.53585156
11	maturation of SSU-rRNA (GO:0030490)	4.37239946
12	positive thymic T cell selection (GO:0045059)	4.18092055
13	relaxation of smooth muscle (GO:0044557)	4.12774172
14	pseudouridine synthesis (GO:0001522)	4.12013147
15	Arp2/3 complex-mediated actin nucleation (GO:0034314)	4.08020761
16	platelet dense granule organization (GO:0060155)	4.07670731
17	peroxisome fission (GO:0016559)	3.99574653
18	negative regulation of inclusion body assembly (GO:0090084)	3.89865027
19	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	3.89861213
20	positive regulation of interleukin-8 secretion (GO:2000484)	3.87870406
21	dermatan sulfate biosynthetic process (GO:0030208)	3.84883578
22	negative regulation of amino acid transport (GO:0051956)	3.72797540
23	piRNA metabolic process (GO:0034587)	3.69635271
24	actin nucleation (GO:0045010)	3.65802460
25	ribosomal small subunit assembly (GO:0000028)	3.59911647
26	negative regulation of multicellular organism growth (GO:0040015)	3.52571183
27	AMP metabolic process (GO:0046033)	3.51003444
28	T cell receptor signaling pathway (GO:0050852)	3.46839584
29	glucosamine-containing compound catabolic process (GO:1901072)	3.45122866
30	positive regulation of alpha-beta T cell proliferation (GO:0046641)	3.44395750
31	positive regulation of tolerance induction (GO:0002645)	3.43343635
32	positive regulation of T cell mediated cytotoxicity (GO:0001916)	3.43117949
33	dermatan sulfate metabolic process (GO:0030205)	3.41333276
34	negative thymic T cell selection (GO:0045060)	3.39794585
35	cytidine metabolic process (GO:0046087)	3.38476296
36	cytidine catabolic process (GO:0006216)	3.38476296
37	cytidine deamination (GO:0009972)	3.38476296
38	regulation of leukocyte mediated cytotoxicity (GO:0001910)	3.38094072
39	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.37787813
40	positive regulation of cell killing (GO:0031343)	3.36171547
41	ribosomal large subunit biogenesis (GO:0042273)	3.34310165
42	viral transcription (GO:0019083)	3.33387406
43	translational termination (GO:0006415)	3.27352128
44	DNA deamination (GO:0045006)	3.26318625
45	regulation of gamma-delta T cell differentiation (GO:0045586)	3.19754499
46	response to pheromone (GO:0019236)	3.18495165
47	negative regulation of protein autophosphorylation (GO:0031953)	3.16677047
48	regulation of T cell tolerance induction (GO:0002664)	3.16237996
49	negative regulation by host of viral transcription (GO:0043922)	3.14157074
50	regulation of respiratory system process (GO:0044065)	3.13196431
51	T cell costimulation (GO:0031295)	3.12954186
52	positive regulation of interleukin-2 biosynthetic process (GO:0045086)	3.10232136
53	lymphocyte costimulation (GO:0031294)	3.09232984
54	regulation of interleukin-8 secretion (GO:2000482)	3.06145861
55	regulation of relaxation of muscle (GO:1901077)	3.05016977
56	nucleotide-excision repair, DNA damage removal (GO:0000718)	3.03836451
57	DNA excision (GO:0044349)	3.03836451
58	negative regulation of T cell apoptotic process (GO:0070233)	3.01902995
59	cellular ketone body metabolic process (GO:0046950)	3.01657075
60	negative regulation of acute inflammatory response (GO:0002674)	2.97756684
61	thymic T cell selection (GO:0045061)	2.97364893
62	regulation of glutamate secretion (GO:0014048)	2.96410747
63	gamma-aminobutyric acid transport (GO:0015812)	2.94059505
64	regulation of cell killing (GO:0031341)	2.93906342
65	regulation of glomerular filtration (GO:0003093)	2.92521899
66	detection of temperature stimulus involved in sensory perception (GO:0050961)	2.91622426
67	detection of temperature stimulus involved in sensory perception of pain (GO:0050965)	2.91622426
68	regulation of alpha-beta T cell proliferation (GO:0046640)	2.90658969
69	male meiosis (GO:0007140)	2.88935826
70	antigen receptor-mediated signaling pathway (GO:0050851)	2.85551186
71	T cell selection (GO:0045058)	2.85421724
72	cullin deneddylation (GO:0010388)	2.84210213
73	regulation of response to tumor cell (GO:0002834)	2.82756848
74	positive regulation of response to tumor cell (GO:0002836)	2.82756848
75	positive regulation of immune response to tumor cell (GO:0002839)	2.82756848
76	regulation of immune response to tumor cell (GO:0002837)	2.82756848
77	sex differentiation (GO:0007548)	2.81079878
78	negative regulation of mast cell activation (GO:0033004)	2.80753225
79	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.79820863
80	skeletal muscle organ development (GO:0060538)	2.79554759
81	2-deoxyribonucleotide biosynthetic process (GO:0009265)	2.79459024
82	deoxyribose phosphate biosynthetic process (GO:0046385)	2.79459024
83	regulation of activation of Janus kinase activity (GO:0010533)	2.76041011
84	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	2.75530532
85	synapsis (GO:0007129)	2.74801636
86	protein targeting to ER (GO:0045047)	2.74278896
87	translational elongation (GO:0006414)	2.73902107
88	purine-containing compound salvage (GO:0043101)	2.71942012
89	ketone body metabolic process (GO:1902224)	2.71816057
90	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.71761402
91	cotranslational protein targeting to membrane (GO:0006613)	2.71306646
92	positive regulation of calcium-mediated signaling (GO:0050850)	2.70992993
93	cellular protein complex disassembly (GO:0043624)	2.68917183
94	regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)	2.68194971
95	sulfation (GO:0051923)	2.65866623
96	regulation of B cell differentiation (GO:0045577)	2.62614072
97	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.60650053
98	regulation of T cell mediated cytotoxicity (GO:0001914)	2.59975202
99	negative regulation of humoral immune response (GO:0002921)	2.59823482
100	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.59488573

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	4.74411661
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.63821334
3	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	3.57033299
4	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.51572963
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.51087460
6	NOTCH1_21737748_ChIP-Seq_TLL_Human	3.50108008
7	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.94172251
8	RUNX_20019798_ChIP-Seq_JUKART_Human	2.86065722
9	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.55681639
10	MYB_26560356_Chip-Seq_TH2_Human	2.52211074
11	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.38260356
12	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.35148374
13	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.23793472
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.05379765
15	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.99894824
16	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.94078559
17	EZH2_22144423_ChIP-Seq_EOC_Human	1.88242149
18	ER_23166858_ChIP-Seq_MCF-7_Human	1.88169203
19	STAT3_20064451_ChIP-Seq_CD4+T_Mouse	1.79522464
20	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.79423401
21	FUS_26573619_Chip-Seq_HEK293_Human	1.78712444
22	IGF1R_20145208_ChIP-Seq_DFB_Human	1.72226781
23	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.69632395
24	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.67915896
25	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.64643737
26	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.60665944
27	TAF15_26573619_Chip-Seq_HEK293_Human	1.56222210
28	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.54172396
29	GATA3_26560356_Chip-Seq_TH2_Human	1.52526485
30	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.48891223
31	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.41861320
32	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.40843194
33	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.40252641
34	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.36341910
35	BCAT_22108803_ChIP-Seq_LS180_Human	1.35630433
36	GATA1_22025678_ChIP-Seq_K562_Human	1.35126567
37	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.33705499
38	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.31054002
39	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.27967405
40	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.27301041
41	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.27252671
42	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.26296059
43	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.25648975
44	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.21414536
45	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.21290704
46	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.19953077
47	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.19159795
48	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.18812338
49	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.17829185
50	P300_19829295_ChIP-Seq_ESCs_Human	1.17768110
51	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.16823019
52	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	1.16263184
53	ETV1_20927104_ChIP-Seq_GIST48_Human	1.15837697
54	NFYB_21822215_ChIP-Seq_K562_Human	1.15565794
55	RBPJ_21746931_ChIP-Seq_IB4_Human	1.15474578
56	PHF8_20622853_ChIP-Seq_HELA_Human	1.13496764
57	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.13254969
58	TCF4_22108803_ChIP-Seq_LS180_Human	1.13013727
59	STAT1_20625510_ChIP-Seq_HELA_Human	1.12632637
60	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.11811811
61	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.09862699
62	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.09862699
63	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.09729015
64	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.09354137
65	TAF2_19829295_ChIP-Seq_ESCs_Human	1.07753992
66	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.06655306
67	UTX_26944678_Chip-Seq_JUKART_Human	1.05936948
68	EWS_26573619_Chip-Seq_HEK293_Human	1.05753444
69	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.05604132
70	CBP_20019798_ChIP-Seq_JUKART_Human	1.05604132
71	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.02016726
72	SPI1_20517297_ChIP-Seq_HL60_Human	1.01204232
73	NFYA_21822215_ChIP-Seq_K562_Human	1.00883802
74	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.00772212
75	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.00380827
76	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.99715448
77	NCOR_22424771_ChIP-Seq_293T_Human	0.98606266
78	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.97626360
79	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.97489238
80	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.97336317
81	IRF1_19129219_ChIP-ChIP_H3396_Human	0.97266671
82	GATA3_27048872_Chip-Seq_THYMUS_Human	0.96983720
83	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.96181704
84	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.95968740
85	MAF_26560356_Chip-Seq_TH1_Human	0.95893315
86	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.95842530
87	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.95479084
88	MYC_19829295_ChIP-Seq_ESCs_Human	0.94433918
89	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.93082949
90	MAF_26560356_Chip-Seq_TH2_Human	0.92600342
91	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.90827384
92	AR_25329375_ChIP-Seq_VCAP_Human	0.90726096
93	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.90472002
94	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.89996148
95	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.89946474
96	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.89706862
97	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.88862883
98	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.87416693
99	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.87209423
100	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	0.87156415

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	6.48336121
2	MP0002009_preneoplasia	4.19695095
3	MP0002166_altered_tumor_susceptibility	3.45055717
4	MP0005671_abnormal_response_to	3.01670748
5	MP0002006_tumorigenesis	2.76499635
6	MP0004147_increased_porphyrin_level	2.73098372
7	MP0003878_abnormal_ear_physiology	2.71326697
8	MP0005377_hearing/vestibular/ear_phenot	2.71326697
9	MP0002277_abnormal_respiratory_mucosa	2.54645762
10	MP0003806_abnormal_nucleotide_metabolis	2.46322722
11	MP0001485_abnormal_pinna_reflex	2.33279011
12	MP0002928_abnormal_bile_duct	2.29067866
13	MP0008877_abnormal_DNA_methylation	2.21525329
14	MP0003183_abnormal_peptide_metabolism	2.20929165
15	MP0003786_premature_aging	2.06702080
16	MP0009785_altered_susceptibility_to	2.03596346
17	MP0004134_abnormal_chest_morphology	1.94805041
18	MP0004381_abnormal_hair_follicle	1.92908909
19	MP0004185_abnormal_adipocyte_glucose	1.91436643
20	MP0003763_abnormal_thymus_physiology	1.88542161
21	MP0003567_abnormal_fetal_cardiomyocyte	1.87851726
22	MP0003195_calcinosis	1.85382486
23	MP0008875_abnormal_xenobiotic_pharmacok	1.84503323
24	MP0005000_abnormal_immune_tolerance	1.76088996
25	MP0008004_abnormal_stomach_pH	1.75931840
26	MP0001835_abnormal_antigen_presentation	1.71479385
27	MP0004142_abnormal_muscle_tone	1.66077772
28	MP0008007_abnormal_cellular_replicative	1.62879302
29	MP0003252_abnormal_bile_duct	1.53348406
30	MP0002933_joint_inflammation	1.52321538
31	MP0005503_abnormal_tendon_morphology	1.48675020
32	MP0002160_abnormal_reproductive_system	1.40896719
33	MP0002420_abnormal_adaptive_immunity	1.39077601
34	MP0005167_abnormal_blood-brain_barrier	1.38572519
35	MP0003724_increased_susceptibility_to	1.37430630
36	MP0001968_abnormal_touch/_nociception	1.37308129
37	MP0003448_altered_tumor_morphology	1.34361293
38	MP0003638_abnormal_response/metabolism_	1.34318948
39	MP0005187_abnormal_penis_morphology	1.33899953
40	MP0001819_abnormal_immune_cell	1.30687020
41	MP0005025_abnormal_response_to	1.29191111
42	MP0002102_abnormal_ear_morphology	1.26634371
43	MP0000343_altered_response_to	1.26061485
44	MP0005551_abnormal_eye_electrophysiolog	1.22848635
45	MP0002132_abnormal_respiratory_system	1.21564139
46	MP0002736_abnormal_nociception_after	1.18862078
47	MP0001986_abnormal_taste_sensitivity	1.16548757
48	MP0005410_abnormal_fertilization	1.16531304
49	MP0006072_abnormal_retinal_apoptosis	1.15108184
50	MP0000703_abnormal_thymus_morphology	1.14638353
51	MP0001800_abnormal_humoral_immune	1.13172259
52	MP0001963_abnormal_hearing_physiology	1.11757224
53	MP0004133_heterotaxia	1.11643529
54	MP0002398_abnormal_bone_marrow	1.10535750
55	MP0002723_abnormal_immune_serum	1.08980041
56	MP0000716_abnormal_immune_system	1.06764318
57	MP0002095_abnormal_skin_pigmentation	1.05507988
58	MP0001764_abnormal_homeostasis	1.04964122
59	MP0000013_abnormal_adipose_tissue	1.03981282
60	MP0008872_abnormal_physiological_respon	1.02411782
61	MP0009379_abnormal_foot_pigmentation	1.01314878
62	MP0000631_abnormal_neuroendocrine_gland	0.98626043
63	MP0009764_decreased_sensitivity_to	0.95975587
64	MP0004043_abnormal_pH_regulation	0.95486276
65	MP0002148_abnormal_hypersensitivity_rea	0.94388436
66	MP0004742_abnormal_vestibular_system	0.93392776
67	MP0005310_abnormal_salivary_gland	0.90084136
68	MP0003943_abnormal_hepatobiliary_system	0.89447431
69	MP0006082_CNS_inflammation	0.88193698
70	MP0005085_abnormal_gallbladder_physiolo	0.87102416
71	MP0002332_abnormal_exercise_endurance	0.86622730
72	MP0005084_abnormal_gallbladder_morpholo	0.86117887
73	MP0009763_increased_sensitivity_to	0.84168253
74	MP0010307_abnormal_tumor_latency	0.84092805
75	MP0002722_abnormal_immune_system	0.81753057
76	MP0005535_abnormal_body_temperature	0.81530401
77	MP0000689_abnormal_spleen_morphology	0.81350882
78	MP0005389_reproductive_system_phenotype	0.80952659
79	MP0005266_abnormal_metabolism	0.80232302
80	MP0005257_abnormal_intraocular_pressure	0.79692767
81	MP0000026_abnormal_inner_ear	0.79085816
82	MP0002429_abnormal_blood_cell	0.77902847
83	MP0005666_abnormal_adipose_tissue	0.77572456
84	MP0003866_abnormal_defecation	0.76764549
85	MP0000427_abnormal_hair_cycle	0.75997757
86	MP0002452_abnormal_antigen_presenting	0.75005949
87	MP0009745_abnormal_behavioral_response	0.73110626
88	MP0001765_abnormal_ion_homeostasis	0.70013769
89	MP0002405_respiratory_system_inflammati	0.68098176
90	MP0001661_extended_life_span	0.68002790
91	MP0009765_abnormal_xenobiotic_induced	0.66513686
92	MP0001501_abnormal_sleep_pattern	0.66490648
93	MP0000358_abnormal_cell_content/	0.64943790
94	MP0005253_abnormal_eye_physiology	0.63622351
95	MP0005647_abnormal_sex_gland	0.62221686
96	MP0005387_immune_system_phenotype	0.61857432
97	MP0001790_abnormal_immune_system	0.61857432
98	MP0002419_abnormal_innate_immunity	0.61165092
99	MP0002693_abnormal_pancreas_physiology	0.56839519
100	MP0004130_abnormal_muscle_cell	0.56694836

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Panhypogammaglobulinemia (HP:0003139)	4.74485438
2	Elevated erythrocyte sedimentation rate (HP:0003565)	4.34137372
3	Large eyes (HP:0001090)	4.13138529
4	Bilateral microphthalmos (HP:0007633)	3.73592701
5	Chronic mucocutaneous candidiasis (HP:0002728)	3.59858742
6	Recurrent cutaneous fungal infections (HP:0011370)	3.59858742
7	Abnormal number of erythroid precursors (HP:0012131)	3.57033957
8	Aplastic anemia (HP:0001915)	3.43979841
9	Encephalitis (HP:0002383)	3.37150832
10	Increased intramyocellular lipid droplets (HP:0012240)	3.34878352
11	Abnormal delayed hypersensitivity skin test (HP:0002963)	3.31768127
12	Supernumerary spleens (HP:0009799)	3.27501178
13	Abnormal number of incisors (HP:0011064)	3.23564590
14	Abnormality of cells of the erythroid lineage (HP:0012130)	3.23265440
15	T lymphocytopenia (HP:0005403)	3.14051155
16	Abnormality of DNA repair (HP:0003254)	2.99287872
17	Abnormality of T cells (HP:0002843)	2.93501630
18	Abnormality of the 4th metacarpal (HP:0010012)	2.90173454
19	Agammaglobulinemia (HP:0004432)	2.76416481
20	Absent/shortened dynein arms (HP:0200106)	2.73205450
21	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.73205450
22	Autoimmune hemolytic anemia (HP:0001890)	2.67460147
23	Macrocytic anemia (HP:0001972)	2.64870246
24	Entropion (HP:0000621)	2.64583022
25	Abnormality of T cell number (HP:0011839)	2.63148559
26	Congenital, generalized hypertrichosis (HP:0004540)	2.62493372
27	Abnormality of T cell physiology (HP:0011840)	2.59736143
28	Increased muscle lipid content (HP:0009058)	2.59688638
29	Abnormal rod and cone electroretinograms (HP:0008323)	2.58348136
30	Concave nail (HP:0001598)	2.56413469
31	Congenital stationary night blindness (HP:0007642)	2.53285566
32	Severe combined immunodeficiency (HP:0004430)	2.51556935
33	Colitis (HP:0002583)	2.50040767
34	IgG deficiency (HP:0004315)	2.48888823
35	Microretrognathia (HP:0000308)	2.48850269
36	Depressed nasal tip (HP:0000437)	2.46878499
37	Attenuation of retinal blood vessels (HP:0007843)	2.45017680
38	Sclerocornea (HP:0000647)	2.44468543
39	Hemiplegia (HP:0002301)	2.43071382
40	True hermaphroditism (HP:0010459)	2.38336740
41	Hypoproteinemia (HP:0003075)	2.35370914
42	Asplenia (HP:0001746)	2.31619255
43	Spontaneous hematomas (HP:0007420)	2.27035938
44	Reduced subcutaneous adipose tissue (HP:0003758)	2.21906443
45	Hypotelorism (HP:0000601)	2.19797646
46	IgM deficiency (HP:0002850)	2.14071386
47	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.12854889
48	Intestinal atresia (HP:0011100)	2.12728264
49	Large earlobe (HP:0009748)	2.12174927
50	Pallor (HP:0000980)	2.11095734
51	Progressive cerebellar ataxia (HP:0002073)	2.09606626
52	Abnormality of the anterior chamber (HP:0000593)	2.06022393
53	Neoplasm of the heart (HP:0100544)	2.03507639
54	Microcytic anemia (HP:0001935)	2.02773007
55	Abnormal hand bone ossification (HP:0010660)	2.01469991
56	Combined immunodeficiency (HP:0005387)	1.99594038
57	Meningitis (HP:0001287)	1.99568688
58	Chorioretinal atrophy (HP:0000533)	1.97714585
59	Recurrent skin infections (HP:0001581)	1.97097199
60	Reticulocytopenia (HP:0001896)	1.92495644
61	Renal Fanconi syndrome (HP:0001994)	1.91474204
62	Bone cyst (HP:0012062)	1.90592112
63	Brittle hair (HP:0002299)	1.90541603
64	Myositis (HP:0100614)	1.90129308
65	Distal arthrogryposis (HP:0005684)	1.89819410
66	Abnormality of the fingertips (HP:0001211)	1.89542372
67	Pancreatic cysts (HP:0001737)	1.89100463
68	Abnormal umbilical cord blood vessels (HP:0011403)	1.88277190
69	Single umbilical artery (HP:0001195)	1.88277190
70	Abnormality of the fetal cardiovascular system (HP:0010948)	1.88277190
71	Conjunctival telangiectasia (HP:0000524)	1.85882494
72	Retrobulbar optic neuritis (HP:0100654)	1.84812858
73	Optic neuritis (HP:0100653)	1.84812858
74	Recurrent fungal infections (HP:0002841)	1.82451191
75	2-3 toe syndactyly (HP:0004691)	1.81132141
76	Abnormality of the costochondral junction (HP:0000919)	1.80075387
77	Constricted visual fields (HP:0001133)	1.79904070
78	Postaxial foot polydactyly (HP:0001830)	1.79318818
79	Lymphopenia (HP:0001888)	1.79258544
80	Bile duct proliferation (HP:0001408)	1.78881626
81	Abnormal biliary tract physiology (HP:0012439)	1.78881626
82	Pancreatic fibrosis (HP:0100732)	1.78196641
83	Basal ganglia calcification (HP:0002135)	1.77842027
84	Rectal prolapse (HP:0002035)	1.76214899
85	Absent speech (HP:0001344)	1.75700752
86	Increased hepatocellular lipid droplets (HP:0006565)	1.75386093
87	Diastasis recti (HP:0001540)	1.73809556
88	Abnormality of the diencephalon (HP:0010662)	1.72559604
89	Neuroendocrine neoplasm (HP:0100634)	1.70699047
90	Abnormal mitochondria in muscle tissue (HP:0008316)	1.70172390
91	Thyroiditis (HP:0100646)	1.69978441
92	Abnormality of the umbilical cord (HP:0010881)	1.69001062
93	Chronic sinusitis (HP:0011109)	1.68879234
94	Inflammation of the large intestine (HP:0002037)	1.68661058
95	Occipital encephalocele (HP:0002085)	1.68280556
96	Abnormal ossification of hand bones (HP:0005921)	1.68122236
97	Tented upper lip vermilion (HP:0010804)	1.67982223
98	Recurrent viral infections (HP:0004429)	1.67927315
99	Anhidrosis (HP:0000970)	1.66589113
100	Natal tooth (HP:0000695)	1.66396958

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAPK15	5.35131704
2	TSSK6	4.82940273
3	TXK	4.23795138
4	KDR	4.08395920
5	MAPKAPK3	3.38650298
6	TESK2	2.94577598
7	VRK1	2.87416459
8	CDK19	2.53238885
9	NME1	2.30593975
10	CDK3	2.16570627
11	TLK1	2.10117458
12	ZAK	2.02251937
13	WEE1	1.78653282
14	TYRO3	1.65612354
15	TAOK3	1.64639505
16	NTRK3	1.63986330
17	MAP4K1	1.63583308
18	CDK8	1.61037042
19	CDK12	1.57692821
20	BRD4	1.53254354
21	MAP3K2	1.51230293
22	MAP2K6	1.44188822
23	IRAK4	1.37833307
24	DYRK1B	1.33137254
25	PIM1	1.33095378
26	BRSK2	1.32807373
27	PNCK	1.27550708
28	IRAK2	1.25498300
29	FGFR2	1.23068482
30	ZAP70	1.21823969
31	ITK	1.10139537
32	TESK1	1.09242723
33	RPS6KB2	1.07148553
34	LIMK1	1.04094001
35	MAPKAPK5	1.01598937
36	ADRBK2	0.98616769
37	RPS6KA4	0.98384750
38	SYK	0.96683166
39	TIE1	0.96196796
40	RPS6KA5	0.95053589
41	LCK	0.93213794
42	BTK	0.91810725
43	NTRK2	0.90245759
44	GRK7	0.90079063
45	YES1	0.89757637
46	MAP3K5	0.82325224
47	KSR2	0.80346110
48	LYN	0.79768750
49	UHMK1	0.78822033
50	NLK	0.77308487
51	MAP3K6	0.76324703
52	PRKCQ	0.73576567
53	ADRBK1	0.72360133
54	STK38L	0.70685852
55	OXSR1	0.67959886
56	TEC	0.67763622
57	IRAK1	0.66085324
58	PIK3CA	0.65409085
59	OBSCN	0.64794364
60	BLK	0.62714804
61	FES	0.62419215
62	MARK3	0.62405461
63	GRK1	0.61411457
64	TGFBR1	0.61056086
65	TBK1	0.60356100
66	GRK6	0.57528556
67	LMTK2	0.57376653
68	VRK2	0.56379565
69	MKNK2	0.56370230
70	DMPK	0.54756376
71	KSR1	0.53996377
72	SCYL2	0.53558367
73	IGF1R	0.51914193
74	RAF1	0.50961116
75	PKN1	0.48593289
76	RET	0.47783364
77	FRK	0.46292160
78	CSK	0.43824841
79	NEK9	0.43651097
80	ABL1	0.42632611
81	PLK3	0.39903529
82	MELK	0.39154547
83	CSF1R	0.38975851
84	LRRK2	0.38711272
85	HCK	0.38179135
86	RPS6KA6	0.37900351
87	IKBKE	0.36862057
88	NEK6	0.36849293
89	PDK1	0.35486978
90	JAK2	0.33884086
91	PASK	0.32240090
92	MUSK	0.30909930
93	INSRR	0.29699120
94	PRKD1	0.28702487
95	RPS6KC1	0.26334167
96	RPS6KL1	0.26334167
97	PHKG2	0.25566611
98	PHKG1	0.25566611
99	BMPR1B	0.22020060
100	FGFR3	0.19110865

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	4.45993012
2	Primary immunodeficiency_Homo sapiens_hsa05340	4.13086446
3	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	4.08421447
4	Ribosome_Homo sapiens_hsa03010	3.12985779
5	Butanoate metabolism_Homo sapiens_hsa00650	2.76856172
6	T cell receptor signaling pathway_Homo sapiens_hsa04660	2.59846139
7	Antigen processing and presentation_Homo sapiens_hsa04612	2.40397121
8	RNA polymerase_Homo sapiens_hsa03020	2.36981376
9	Nitrogen metabolism_Homo sapiens_hsa00910	2.36781019
10	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	2.31664240
11	Malaria_Homo sapiens_hsa05144	2.14889864
12	Oxidative phosphorylation_Homo sapiens_hsa00190	1.98273699
13	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.84938006
14	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.77475773
15	Allograft rejection_Homo sapiens_hsa05330	1.64580327
16	Parkinsons disease_Homo sapiens_hsa05012	1.59694099
17	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.59667504
18	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.58659843
19	Measles_Homo sapiens_hsa05162	1.49657194
20	Propanoate metabolism_Homo sapiens_hsa00640	1.48726605
21	Graft-versus-host disease_Homo sapiens_hsa05332	1.44869748
22	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.40547217
23	Type I diabetes mellitus_Homo sapiens_hsa04940	1.39772043
24	African trypanosomiasis_Homo sapiens_hsa05143	1.32717730
25	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.30661310
26	Leishmaniasis_Homo sapiens_hsa05140	1.29526771
27	Cardiac muscle contraction_Homo sapiens_hsa04260	1.25740081
28	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.22312622
29	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.21304473
30	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.21227371
31	Legionellosis_Homo sapiens_hsa05134	1.16286165
32	Proteasome_Homo sapiens_hsa03050	1.11909178
33	Morphine addiction_Homo sapiens_hsa05032	1.09857459
34	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	1.01951177
35	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	1.01045245
36	Purine metabolism_Homo sapiens_hsa00230	0.98765828
37	Linoleic acid metabolism_Homo sapiens_hsa00591	0.97327899
38	Shigellosis_Homo sapiens_hsa05131	0.94641962
39	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.94495544
40	Alzheimers disease_Homo sapiens_hsa05010	0.92304977
41	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.92212117
42	GABAergic synapse_Homo sapiens_hsa04727	0.91631447
43	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.91163596
44	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.88909431
45	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.88331711
46	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.87550098
47	Olfactory transduction_Homo sapiens_hsa04740	0.87345849
48	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.82988945
49	Huntingtons disease_Homo sapiens_hsa05016	0.82414769
50	Pertussis_Homo sapiens_hsa05133	0.81107827
51	Pyrimidine metabolism_Homo sapiens_hsa00240	0.80617610
52	Protein export_Homo sapiens_hsa03060	0.79709204
53	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.78713020
54	One carbon pool by folate_Homo sapiens_hsa00670	0.78013246
55	Nucleotide excision repair_Homo sapiens_hsa03420	0.76789087
56	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.76017772
57	Salmonella infection_Homo sapiens_hsa05132	0.70778220
58	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.69742186
59	Tryptophan metabolism_Homo sapiens_hsa00380	0.68957542
60	Prion diseases_Homo sapiens_hsa05020	0.68722798
61	cAMP signaling pathway_Homo sapiens_hsa04024	0.67626109
62	Phototransduction_Homo sapiens_hsa04744	0.65580461
63	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.64031727
64	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.60245975
65	Peroxisome_Homo sapiens_hsa04146	0.59831081
66	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.58585374
67	ABC transporters_Homo sapiens_hsa02010	0.57048012
68	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.56739815
69	Taste transduction_Homo sapiens_hsa04742	0.56456311
70	Caffeine metabolism_Homo sapiens_hsa00232	0.55382149
71	Chemical carcinogenesis_Homo sapiens_hsa05204	0.55357078
72	Rheumatoid arthritis_Homo sapiens_hsa05323	0.53042702
73	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.51251826
74	Fanconi anemia pathway_Homo sapiens_hsa03460	0.47004044
75	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.45777309
76	VEGF signaling pathway_Homo sapiens_hsa04370	0.45562430
77	Regulation of autophagy_Homo sapiens_hsa04140	0.45014528
78	Asthma_Homo sapiens_hsa05310	0.44874636
79	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.44807811
80	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.44727079
81	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.44700138
82	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.44503867
83	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.43572326
84	Retinol metabolism_Homo sapiens_hsa00830	0.41463041
85	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.37974583
86	Choline metabolism in cancer_Homo sapiens_hsa05231	0.37452812
87	Homologous recombination_Homo sapiens_hsa03440	0.35301986
88	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.34713036
89	Fatty acid metabolism_Homo sapiens_hsa01212	0.33740378
90	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.32009170
91	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.31735426
92	Influenza A_Homo sapiens_hsa05164	0.30802137
93	Renin secretion_Homo sapiens_hsa04924	0.30485994
94	Toxoplasmosis_Homo sapiens_hsa05145	0.26470668
95	Nicotine addiction_Homo sapiens_hsa05033	0.26049834
96	Fat digestion and absorption_Homo sapiens_hsa04975	0.26027933
97	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.25191673
98	Fatty acid elongation_Homo sapiens_hsa00062	0.25112291
99	Notch signaling pathway_Homo sapiens_hsa04330	0.22832544
100	Pancreatic secretion_Homo sapiens_hsa04972	0.21656415

PRR13P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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