PRR13P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Arp2/3 complex-mediated actin nucleation (GO:0034314)7.50409884
2actin nucleation (GO:0045010)6.62897829
3positive thymic T cell selection (GO:0045059)5.77766225
4negative regulation by host of viral transcription (GO:0043922)5.77254837
5positive T cell selection (GO:0043368)5.55529092
6eosinophil chemotaxis (GO:0048245)5.48247202
7positive regulation of interleukin-8 secretion (GO:2000484)5.12431167
8pyrimidine nucleoside catabolic process (GO:0046135)5.08080862
9positive regulation of tolerance induction (GO:0002645)5.05392114
10T cell migration (GO:0072678)5.01717179
11eosinophil migration (GO:0072677)4.95810869
12positive regulation of natural killer cell mediated immunity (GO:0002717)4.94892568
13negative regulation of T cell apoptotic process (GO:0070233)4.94674793
14regulation of activation of Janus kinase activity (GO:0010533)4.93976679
15regulation of T cell tolerance induction (GO:0002664)4.92132934
16positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.90446347
17negative regulation of viral genome replication (GO:0045071)4.81811008
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.70173156
19regulation of lymphocyte chemotaxis (GO:1901623)4.62667219
20cellular response to interleukin-15 (GO:0071350)4.62584358
21cytolysis (GO:0019835)4.60065820
22negative T cell selection (GO:0043383)4.57374832
23thymic T cell selection (GO:0045061)4.56892183
24positive regulation of calcium-mediated signaling (GO:0050850)4.53080809
25regulation of regulatory T cell differentiation (GO:0045589)4.38988510
26positive regulation of gamma-delta T cell activation (GO:0046645)4.29496359
27macrophage chemotaxis (GO:0048246)4.27695416
28regulation of natural killer cell mediated immunity (GO:0002715)4.25033384
29regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.25033384
30positive regulation of monocyte chemotaxis (GO:0090026)4.20367018
31regulation of gamma-delta T cell differentiation (GO:0045586)4.07853023
32positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.04151109
33regulation of tolerance induction (GO:0002643)4.00603340
34regulation of T cell chemotaxis (GO:0010819)3.98673958
35positive regulation of T cell chemotaxis (GO:0010820)3.98673958
36positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.98418081
37positive regulation of lymphocyte migration (GO:2000403)3.93047023
38regulation of B cell receptor signaling pathway (GO:0050855)3.92410380
39T cell selection (GO:0045058)3.90432474
40response to interleukin-15 (GO:0070672)3.89070572
41regulation of chronic inflammatory response (GO:0002676)3.89003463
42sequestering of actin monomers (GO:0042989)3.88641815
43regulation of interleukin-8 secretion (GO:2000482)3.80242772
44positive regulation of B cell differentiation (GO:0045579)3.78344757
45negative thymic T cell selection (GO:0045060)3.75670078
46T cell costimulation (GO:0031295)3.72966128
47lymphocyte chemotaxis (GO:0048247)3.72761497
48lymphocyte costimulation (GO:0031294)3.68286350
49positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.66867240
50monocyte chemotaxis (GO:0002548)3.65716067
51regulation of interleukin-2 biosynthetic process (GO:0045076)3.58892233
52positive regulation of cell killing (GO:0031343)3.57265477
53negative regulation of lymphocyte apoptotic process (GO:0070229)3.49962141
54regulation of viral genome replication (GO:0045069)3.49413655
55regulation of leukocyte mediated cytotoxicity (GO:0001910)3.47543473
56positive regulation of interleukin-4 production (GO:0032753)3.46802173
57T cell receptor signaling pathway (GO:0050852)3.46612587
58positive regulation of translational initiation (GO:0045948)3.46537365
59positive regulation of uterine smooth muscle contraction (GO:0070474)3.45843964
60regulation of B cell differentiation (GO:0045577)3.44408105
61regulation of T cell receptor signaling pathway (GO:0050856)3.41644631
62positive regulation of defense response to virus by host (GO:0002230)3.40186026
63DNA demethylation (GO:0080111)3.39246546
64regulation of gamma-delta T cell activation (GO:0046643)3.35483215
65modulation by host of viral transcription (GO:0043921)3.35094796
66modulation by host of symbiont transcription (GO:0052472)3.35094796
67antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.33084848
68antigen processing and presentation via MHC class Ib (GO:0002475)3.31464030
69negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.30450965
70regulation of calcium-mediated signaling (GO:0050848)3.26150245
71iron-sulfur cluster assembly (GO:0016226)3.23233231
72metallo-sulfur cluster assembly (GO:0031163)3.23233231
73modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)3.21831469
74negative regulation of B cell proliferation (GO:0030889)3.18044357
75negative regulation of viral transcription (GO:0032897)3.16694151
76regulation of cell killing (GO:0031341)3.16159881
77regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.15303008
78negative regulation of viral process (GO:0048525)3.13418065
79antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.13035129
80positive regulation of T cell apoptotic process (GO:0070234)3.08947057
81positive regulation of T cell mediated cytotoxicity (GO:0001916)3.08541253
82positive regulation of alpha-beta T cell proliferation (GO:0046641)3.07243414
83regulation of cellular amino acid metabolic process (GO:0006521)3.06607915
84lymphocyte migration (GO:0072676)3.06031079
85response to interferon-beta (GO:0035456)3.02711799
86regulation of chemokine-mediated signaling pathway (GO:0070099)3.02131925
87antigen receptor-mediated signaling pathway (GO:0050851)3.00157249
88pyrimidine-containing compound catabolic process (GO:0072529)2.99890979
89regulation of interleukin-12 biosynthetic process (GO:0045075)2.99230249
90chemokine-mediated signaling pathway (GO:0070098)2.97714276
91protein neddylation (GO:0045116)2.97424906
92DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.97325653
93regulation of T cell apoptotic process (GO:0070232)2.96746131
94regulation of alpha-beta T cell proliferation (GO:0046640)2.96511438
95cytidine catabolic process (GO:0006216)11.5491207
96cytidine deamination (GO:0009972)11.5491207
97cytidine metabolic process (GO:0046087)11.5491207
98regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:004509110.2065216
99pyrimidine ribonucleoside catabolic process (GO:0046133)10.1592071
100DNA deamination (GO:0045006)10.1300223

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human9.72197400
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.09984973
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.34067796
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.26419641
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.12822991
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.51531267
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.36636777
8ELF1_17652178_ChIP-ChIP_JURKAT_Human3.11147448
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.10928873
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.94385354
11MYB_26560356_Chip-Seq_TH2_Human2.82023997
12STAT4_19710469_ChIP-ChIP_TH1__Mouse2.57479095
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.26478067
14STAT6_21828071_ChIP-Seq_BEAS2B_Human2.21734488
15RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.15351058
16RUNX_20019798_ChIP-Seq_JUKART_Human2.10559247
17GATA3_27048872_Chip-Seq_THYMUS_Human2.10216451
18LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.97339186
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.89910743
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.82934179
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.80427903
22MYB_26560356_Chip-Seq_TH1_Human1.80090275
23GATA3_26560356_Chip-Seq_TH2_Human1.79196550
24GABP_17652178_ChIP-ChIP_JURKAT_Human1.64174402
25VDR_22108803_ChIP-Seq_LS180_Human1.63187944
26HTT_18923047_ChIP-ChIP_STHdh_Human1.60934797
27UTX_26944678_Chip-Seq_JUKART_Human1.58205291
28FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.57108278
29CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.54778313
30KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.54111682
31SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.47762106
32MAF_26560356_Chip-Seq_TH2_Human1.44670132
33FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.44110766
34VDR_23849224_ChIP-Seq_CD4+_Human1.44099435
35IGF1R_20145208_ChIP-Seq_DFB_Human1.42265646
36MAF_26560356_Chip-Seq_TH1_Human1.41599069
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.35950834
38RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.35712327
39TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.35043238
40PCGF2_27294783_Chip-Seq_NPCs_Mouse1.34350030
41JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.34188113
42NOTCH1_21737748_ChIP-Seq_TLL_Human1.33458102
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.26570829
44HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.26271577
45EST1_17652178_ChIP-ChIP_JURKAT_Human1.25971560
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.25710540
47PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.21747178
48EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.20968539
49LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.20252146
50PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.18681685
51SMAD_19615063_ChIP-ChIP_OVARY_Human1.17616570
52YY1_22570637_ChIP-Seq_MALME-3M_Human1.17011459
53SPI1_23547873_ChIP-Seq_NB4_Human1.15439504
54GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.15389311
55TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12366997
56MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.12212099
57TP53_22573176_ChIP-Seq_HFKS_Human1.09514218
58GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.08504912
59TAF2_19829295_ChIP-Seq_ESCs_Human1.08459211
60NCOR_22424771_ChIP-Seq_293T_Human1.05560168
61AR_20517297_ChIP-Seq_VCAP_Human1.02167667
62MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.01704681
63BCL6_27268052_Chip-Seq_Bcells_Human1.01598675
64GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.01171956
65NANOG_20526341_ChIP-Seq_ESCs_Human0.99736655
66IRF8_27001747_Chip-Seq_BMDM_Mouse0.99376504
67SRF_21415370_ChIP-Seq_HL-1_Mouse0.99235169
68CTCF_20526341_ChIP-Seq_ESCs_Human0.98467220
69GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.95176861
70FOXA1_21572438_ChIP-Seq_LNCaP_Human0.93106368
71RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.90270114
72GATA3_26560356_Chip-Seq_TH1_Human0.89781701
73CIITA_25753668_ChIP-Seq_RAJI_Human0.89572555
74BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.89024172
75CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.88768305
76RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.87941829
77FOXP3_21729870_ChIP-Seq_TREG_Human0.86987841
78STAT1_20625510_ChIP-Seq_HELA_Human0.86445986
79RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.85525736
80EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.85279682
81SA1_27219007_Chip-Seq_Bcells_Human0.84486047
82FOXA1_27270436_Chip-Seq_PROSTATE_Human0.84310246
83FOXA1_25329375_ChIP-Seq_VCAP_Human0.84310246
84FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84016022
85P300_27268052_Chip-Seq_Bcells_Human0.82241394
86GATA6_21074721_ChIP-Seq_CACO-2_Human0.81291275
87CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.80883375
88EGR1_23403033_ChIP-Seq_LIVER_Mouse0.80874373
89NFE2_27457419_Chip-Seq_LIVER_Mouse0.79793942
90SOX2_19829295_ChIP-Seq_ESCs_Human0.79369015
91NANOG_19829295_ChIP-Seq_ESCs_Human0.79369015
92MYC_19829295_ChIP-Seq_ESCs_Human0.78710889
93ERG_20517297_ChIP-Seq_VCAP_Human0.78300827
94GATA3_21878914_ChIP-Seq_MCF-7_Human0.77537228
95ETS1_20019798_ChIP-Seq_JURKAT_Human0.77338300
96RBPJ_21746931_ChIP-Seq_IB4_Human0.76571748
97TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.76543592
98TAF15_26573619_Chip-Seq_HEK293_Human0.76408785
99FOXH1_21741376_ChIP-Seq_ESCs_Human0.75385984
100FOXH1_21741376_ChIP-Seq_EPCs_Human0.74239190

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.92185590
2MP0009785_altered_susceptibility_to4.15394448
3MP0001835_abnormal_antigen_presentation3.31204218
4MP0003763_abnormal_thymus_physiology3.30465636
5MP0009333_abnormal_splenocyte_physiolog2.89603523
6MP0003045_fibrosis2.79322349
7MP0002166_altered_tumor_susceptibility2.76964676
8MP0005025_abnormal_response_to2.63126259
9MP0006082_CNS_inflammation2.57917938
10MP0005000_abnormal_immune_tolerance2.56270907
11MP0003866_abnormal_defecation2.50140274
12MP0001873_stomach_inflammation2.45955606
13MP0001800_abnormal_humoral_immune2.44074433
14MP0005377_hearing/vestibular/ear_phenot2.39756089
15MP0003878_abnormal_ear_physiology2.39756089
16MP0002420_abnormal_adaptive_immunity2.37707259
17MP0002148_abnormal_hypersensitivity_rea2.36812055
18MP0002723_abnormal_immune_serum2.32074969
19MP0001819_abnormal_immune_cell2.28797852
20MP0005387_immune_system_phenotype2.25680464
21MP0001790_abnormal_immune_system2.25680464
22MP0003448_altered_tumor_morphology2.20021315
23MP0002006_tumorigenesis2.19562232
24MP0000685_abnormal_immune_system2.06870994
25MP0004147_increased_porphyrin_level2.06079602
26MP0002102_abnormal_ear_morphology2.03094735
27MP0010155_abnormal_intestine_physiology1.91739365
28MP0002452_abnormal_antigen_presenting1.87130815
29MP0000716_abnormal_immune_system1.87123587
30MP0002398_abnormal_bone_marrow1.84646803
31MP0002405_respiratory_system_inflammati1.74345524
32MP0003786_premature_aging1.69788386
33MP0001853_heart_inflammation1.69044741
34MP0002722_abnormal_immune_system1.67361863
35MP0000703_abnormal_thymus_morphology1.64388487
36MP0000689_abnormal_spleen_morphology1.51302011
37MP0001845_abnormal_inflammatory_respons1.50966449
38MP0001188_hyperpigmentation1.48239700
39MP0002933_joint_inflammation1.45771324
40MP0004381_abnormal_hair_follicle1.42792194
41MP0002429_abnormal_blood_cell1.41707518
42MP0004145_abnormal_muscle_electrophysio1.38547315
43MP0002419_abnormal_innate_immunity1.34342416
44MP0000569_abnormal_digit_pigmentation1.34128108
45MP0002837_dystrophic_cardiac_calcinosis1.32786041
46MP0002653_abnormal_ependyma_morphology1.32609387
47MP0002138_abnormal_hepatobiliary_system1.29626508
48MP0006054_spinal_hemorrhage1.23668085
49MP0005075_abnormal_melanosome_morpholog1.20681485
50MP0002877_abnormal_melanocyte_morpholog1.18607560
51MP0003806_abnormal_nucleotide_metabolis1.14127507
52MP0009763_increased_sensitivity_to1.13444907
53MP0004947_skin_inflammation1.12351734
54MP0008469_abnormal_protein_level1.10861653
55MP0001661_extended_life_span1.08315124
56MP0000858_altered_metastatic_potential1.05540902
57MP0005464_abnormal_platelet_physiology1.04271067
58MP0004134_abnormal_chest_morphology1.01721511
59MP0002095_abnormal_skin_pigmentation1.01515520
60MP0003137_abnormal_impulse_conducting0.99386321
61MP0003646_muscle_fatigue0.98929752
62MP0005310_abnormal_salivary_gland0.98532167
63MP0001905_abnormal_dopamine_level0.97441221
64MP0003436_decreased_susceptibility_to0.92726406
65MP0005645_abnormal_hypothalamus_physiol0.92193897
66MP0002019_abnormal_tumor_incidence0.87318408
67MP0002168_other_aberrant_phenotype0.86149320
68MP0001485_abnormal_pinna_reflex0.86146857
69MP0001968_abnormal_touch/_nociception0.85126474
70MP0002876_abnormal_thyroid_physiology0.84058599
71MP0005166_decreased_susceptibility_to0.83613817
72MP0008873_increased_physiological_sensi0.82323246
73MP0002163_abnormal_gland_morphology0.80591092
74MP0009764_decreased_sensitivity_to0.79025198
75MP0006072_abnormal_retinal_apoptosis0.78708627
76MP0003011_delayed_dark_adaptation0.77385904
77MP0000372_irregular_coat_pigmentation0.75808908
78MP0005551_abnormal_eye_electrophysiolog0.75684207
79MP0003136_yellow_coat_color0.75568083
80MP0000749_muscle_degeneration0.75533532
81MP0003075_altered_response_to0.73006366
82MP0002693_abnormal_pancreas_physiology0.72466384
83MP0003195_calcinosis0.69455171
84MP0005174_abnormal_tail_pigmentation0.66495412
85MP0001243_abnormal_dermal_layer0.65493962
86MP0009643_abnormal_urine_homeostasis0.63453104
87MP0005389_reproductive_system_phenotype0.63333741
88MP0009765_abnormal_xenobiotic_induced0.63059522
89MP0001984_abnormal_olfaction0.62801195
90MP0001542_abnormal_bone_strength0.62181367
91MP0001919_abnormal_reproductive_system0.61695862
92MP0005330_cardiomyopathy0.61214091
93MP0002736_abnormal_nociception_after0.60502031
94MP0002136_abnormal_kidney_physiology0.57732221
95MP0003567_abnormal_fetal_cardiomyocyte0.56695380
96MP0005636_abnormal_mineral_homeostasis0.54592822
97MP0006036_abnormal_mitochondrial_physio0.54155740
98MP0001533_abnormal_skeleton_physiology0.53334170
99MP0003252_abnormal_bile_duct0.53308295
100MP0005379_endocrine/exocrine_gland_phen0.52826550

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)7.30843791
2T lymphocytopenia (HP:0005403)7.01820948
3Abnormality of T cell number (HP:0011839)6.68849322
4Autoimmune hemolytic anemia (HP:0001890)5.18331260
5Elevated erythrocyte sedimentation rate (HP:0003565)4.96317150
6Hypoproteinemia (HP:0003075)4.76041579
7Increased IgM level (HP:0003496)4.69016676
8IgG deficiency (HP:0004315)4.65355452
9Abnormality of T cells (HP:0002843)4.37878764
10Severe combined immunodeficiency (HP:0004430)4.10114975
11Abnormality of the prostate (HP:0008775)4.00698441
12Chronic diarrhea (HP:0002028)3.57631999
13Thyroiditis (HP:0100646)3.43651894
14Recurrent bronchitis (HP:0002837)3.31086911
15Stomatitis (HP:0010280)3.24882941
16Abnormality of eosinophils (HP:0001879)3.24064277
17Combined immunodeficiency (HP:0005387)3.21036784
18Decreased activity of mitochondrial respiratory chain (HP:0008972)3.20983140
19Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.20983140
20Amyotrophic lateral sclerosis (HP:0007354)3.16892782
21Abnormal delayed hypersensitivity skin test (HP:0002963)3.15012001
22Renal Fanconi syndrome (HP:0001994)3.14467234
23Generalized aminoaciduria (HP:0002909)3.12684164
24Increased intramyocellular lipid droplets (HP:0012240)3.11183084
25Lymphopenia (HP:0001888)3.02621685
26Abnormality of cells of the lymphoid lineage (HP:0012140)2.92831460
27Mitochondrial inheritance (HP:0001427)2.85604138
28Abnormality of macrophages (HP:0004311)2.81711687
29Meningitis (HP:0001287)2.78577360
30Gangrene (HP:0100758)2.70950224
31Obstructive lung disease (HP:0006536)2.67205603
32Chronic obstructive pulmonary disease (HP:0006510)2.67205603
33Pulmonary infiltrates (HP:0002113)2.64674069
34Autoimmune thrombocytopenia (HP:0001973)2.62173537
35Eosinophilia (HP:0001880)2.60047551
363-Methylglutaconic aciduria (HP:0003535)2.52622532
37Encephalitis (HP:0002383)2.52324895
38Hypoalbuminemia (HP:0003073)2.51721704
39Abnormal albumin level (HP:0012116)2.51721704
40Recurrent cutaneous fungal infections (HP:0011370)2.49572949
41Chronic mucocutaneous candidiasis (HP:0002728)2.49572949
42Increased muscle lipid content (HP:0009058)2.49442233
43Ureteral stenosis (HP:0000071)2.49252288
44Pancytopenia (HP:0001876)2.48597907
45Joint swelling (HP:0001386)2.47901995
46Congenital stationary night blindness (HP:0007642)2.41841855
47Leukocytosis (HP:0001974)2.41382529
48Hemoptysis (HP:0002105)2.39140008
49Bronchitis (HP:0012387)2.38516939
50IgM deficiency (HP:0002850)2.36302471
51Hepatocellular necrosis (HP:0001404)2.32437785
52Chest pain (HP:0100749)2.32338723
53Recurrent otitis media (HP:0000403)2.32329827
54Abnormality of the pleura (HP:0002103)2.31639377
55Abnormality of male internal genitalia (HP:0000022)2.30702873
56Myositis (HP:0100614)2.30679118
57Hypergammaglobulinemia (HP:0010702)2.29280436
58Absent rod-and cone-mediated responses on ERG (HP:0007688)2.25794202
59Abnormality of T cell physiology (HP:0011840)2.24910988
60Abnormal mitochondria in muscle tissue (HP:0008316)2.23097772
61Acute necrotizing encephalopathy (HP:0006965)2.22265668
62Recurrent viral infections (HP:0004429)2.22112015
63Ureteral obstruction (HP:0006000)2.21695626
64Pustule (HP:0200039)2.17417890
65Increased CSF lactate (HP:0002490)2.16302008
66Vasculitis (HP:0002633)2.15251577
67Increased hepatocellular lipid droplets (HP:0006565)2.12636611
68IgA deficiency (HP:0002720)2.12586960
69Radial bowing (HP:0002986)2.12223451
70Pulmonary embolism (HP:0002204)2.11865892
71Lymphoma (HP:0002665)2.11424241
72Recurrent fungal infections (HP:0002841)2.10566214
73Hepatic necrosis (HP:0002605)2.07332177
74Prostate neoplasm (HP:0100787)2.06964784
75Granulocytopenia (HP:0001913)2.05511546
76Hemiplegia (HP:0002301)2.04740056
77Oral leukoplakia (HP:0002745)2.04399156
78Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.99688606
79Pigmentary retinal degeneration (HP:0001146)1.99602867
80Purpura (HP:0000979)1.97053489
81Decreased central vision (HP:0007663)1.96851033
82Abnormal rod and cone electroretinograms (HP:0008323)1.96472642
83Retrobulbar optic neuritis (HP:0100654)1.95795882
84Optic neuritis (HP:0100653)1.95795882
85Pancreatic cysts (HP:0001737)1.95211343
86Hypoplasia of the thymus (HP:0000778)1.94074366
87Agammaglobulinemia (HP:0004432)1.90608128
88Cerebral palsy (HP:0100021)1.87980676
89Abolished electroretinogram (ERG) (HP:0000550)1.87797060
90Gastrointestinal infarctions (HP:0005244)1.86424649
91Spastic paraparesis (HP:0002313)1.85978690
92Progressive macrocephaly (HP:0004481)1.83432292
93Petechiae (HP:0000967)1.81597909
94Pulmonary fibrosis (HP:0002206)1.79710799
95Abnormal drinking behavior (HP:0030082)1.79454330
96Polydipsia (HP:0001959)1.79454330
97Abnormality of B cell number (HP:0010975)1.75753821
98Abnormality of the pericardium (HP:0001697)1.74695045
99Recurrent skin infections (HP:0001581)1.73616071
100Lipid accumulation in hepatocytes (HP:0006561)1.73396575

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK7.94059804
2KDR6.75013957
3TESK25.18870359
4MAP4K12.79852086
5TESK12.52128424
6VRK22.51632280
7ITK2.50192705
8BUB12.34443318
9LIMK12.28222207
10ADRBK22.07217020
11BCKDK1.90522978
12FES1.68789531
13PIK3CA1.68521414
14ZAK1.65986047
15SYK1.63010600
16CSK1.61865787
17MUSK1.55800141
18MAPKAPK31.54808449
19STK161.53712905
20TAOK31.49296972
21FRK1.48948803
22PRKCQ1.38153115
23MAP3K121.35172812
24LCK1.34228263
25EIF2AK31.26816309
26GRK11.24918792
27GRK71.24301833
28SCYL21.19298382
29ZAP701.16172742
30TEC1.11387882
31BTK1.07457452
32VRK11.03059569
33IKBKE1.00682633
34BLK1.00210444
35LYN0.88629110
36IKBKB0.88086367
37WNK40.87351503
38JAK30.85643484
39CSF1R0.85510716
40TLK10.84728379
41MAP2K60.81579738
42TBK10.80204210
43MAP3K110.77102738
44TIE10.69350348
45ROCK10.68706158
46DAPK10.67362316
47FYN0.66008237
48MYLK0.62043647
49IGF1R0.58525352
50CLK10.57546359
51OXSR10.55093883
52GRK60.52386809
53MST40.50486152
54INSRR0.49457534
55GRK50.48888160
56PIK3CG0.47140234
57MAPKAPK50.45656177
58INSR0.45262912
59ADRBK10.42693014
60TGFBR20.41758913
61OBSCN0.41261781
62PAK10.40659301
63MATK0.39648392
64JAK20.36371158
65MAPKAPK20.36268322
66TNK20.35722708
67MAPK110.34597412
68MAP3K50.34141885
69PRKCA0.33918939
70RPS6KA50.33875115
71CAMK2A0.33849210
72NUAK10.33024507
73PIM20.32963736
74MAPK130.32132151
75RIPK40.31730233
76AURKA0.31332783
77BMPR20.27982614
78STK38L0.27791170
79TYRO30.25364717
80PIM10.25078034
81HCK0.23979648
82NME10.22517180
83LATS10.22176670
84TRIM280.21958955
85PRKACA0.21273401
86DAPK30.21102626
87PINK10.20354739
88CSNK1G30.19749121
89WNK30.18772883
90TRPM70.18071787
91PASK0.17948162
92NEK20.17568524
93ABL10.17437185
94CSNK2A10.16840354
95SRC0.16716644
96STK100.16697948
97PRKCB0.16323617
98CSNK1A1L0.15764623
99SRPK10.14384925
100ATR0.14170740

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.24695483
2Proteasome_Homo sapiens_hsa030504.88682668
3Graft-versus-host disease_Homo sapiens_hsa053324.03669310
4Antigen processing and presentation_Homo sapiens_hsa046123.85012344
5Autoimmune thyroid disease_Homo sapiens_hsa053203.60884232
6Allograft rejection_Homo sapiens_hsa053303.19215339
7Hematopoietic cell lineage_Homo sapiens_hsa046403.04558230
8Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.89500336
9T cell receptor signaling pathway_Homo sapiens_hsa046602.81204214
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.69951333
11Oxidative phosphorylation_Homo sapiens_hsa001902.57843119
12Type I diabetes mellitus_Homo sapiens_hsa049402.44208009
13Parkinsons disease_Homo sapiens_hsa050122.21578050
14Rheumatoid arthritis_Homo sapiens_hsa053232.20586129
15Salmonella infection_Homo sapiens_hsa051321.61763547
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.56288205
17Measles_Homo sapiens_hsa051621.55159404
18Alzheimers disease_Homo sapiens_hsa050101.46548506
19Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.44920250
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.44244809
21Viral myocarditis_Homo sapiens_hsa054161.42792942
22Asthma_Homo sapiens_hsa053101.40908250
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.38079113
24Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.34132216
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.30816629
26Shigellosis_Homo sapiens_hsa051311.26593406
27Cardiac muscle contraction_Homo sapiens_hsa042601.18770857
28RNA polymerase_Homo sapiens_hsa030201.18495027
29Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.17692216
30Malaria_Homo sapiens_hsa051441.16119161
31Protein export_Homo sapiens_hsa030601.13407323
32Huntingtons disease_Homo sapiens_hsa050161.12194316
33Phototransduction_Homo sapiens_hsa047441.06580066
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.04775012
35Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.01980902
36NOD-like receptor signaling pathway_Homo sapiens_hsa046210.95437453
37Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.93357217
38Nitrogen metabolism_Homo sapiens_hsa009100.92266266
39Toll-like receptor signaling pathway_Homo sapiens_hsa046200.92008781
40Butanoate metabolism_Homo sapiens_hsa006500.81242774
41Chemokine signaling pathway_Homo sapiens_hsa040620.79555020
42RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.78384643
43Caffeine metabolism_Homo sapiens_hsa002320.76441107
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.75784927
45Linoleic acid metabolism_Homo sapiens_hsa005910.71873149
46Systemic lupus erythematosus_Homo sapiens_hsa053220.66893357
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.65395333
48Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.62730826
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60311463
50Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59615833
51Peroxisome_Homo sapiens_hsa041460.56153663
52Staphylococcus aureus infection_Homo sapiens_hsa051500.54615823
53Herpes simplex infection_Homo sapiens_hsa051680.54425740
54HTLV-I infection_Homo sapiens_hsa051660.49010137
55Homologous recombination_Homo sapiens_hsa034400.42675207
56Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41758736
57Prion diseases_Homo sapiens_hsa050200.41538061
58Ribosome_Homo sapiens_hsa030100.39231936
59Leishmaniasis_Homo sapiens_hsa051400.39207390
60Epstein-Barr virus infection_Homo sapiens_hsa051690.38667764
61Pertussis_Homo sapiens_hsa051330.34204097
62Apoptosis_Homo sapiens_hsa042100.33949162
63Collecting duct acid secretion_Homo sapiens_hsa049660.32863564
64Legionellosis_Homo sapiens_hsa051340.32688281
65Retinol metabolism_Homo sapiens_hsa008300.29513638
66Jak-STAT signaling pathway_Homo sapiens_hsa046300.29483026
67Olfactory transduction_Homo sapiens_hsa047400.29416089
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.26476611
69Influenza A_Homo sapiens_hsa051640.26385650
70Selenocompound metabolism_Homo sapiens_hsa004500.26381940
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.26155535
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24252275
73Regulation of actin cytoskeleton_Homo sapiens_hsa048100.23386094
74Osteoclast differentiation_Homo sapiens_hsa043800.23000105
75TNF signaling pathway_Homo sapiens_hsa046680.21614096
76Purine metabolism_Homo sapiens_hsa002300.19569537
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.19304494
78Fanconi anemia pathway_Homo sapiens_hsa034600.17650389
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.17130894
80Chemical carcinogenesis_Homo sapiens_hsa052040.16883643
81Tryptophan metabolism_Homo sapiens_hsa003800.16138833
82Pyrimidine metabolism_Homo sapiens_hsa002400.15455668
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.15404019
84Taste transduction_Homo sapiens_hsa047420.15399256
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.15262857
86African trypanosomiasis_Homo sapiens_hsa051430.15069817
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.14414434
88ABC transporters_Homo sapiens_hsa020100.13232561
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.12861037
90Morphine addiction_Homo sapiens_hsa050320.12706143
91Endocytosis_Homo sapiens_hsa041440.12099836
92Primary bile acid biosynthesis_Homo sapiens_hsa001200.11682159
93Tuberculosis_Homo sapiens_hsa051520.10725633
94Propanoate metabolism_Homo sapiens_hsa006400.10449179
95RNA degradation_Homo sapiens_hsa030180.10057744
96Ether lipid metabolism_Homo sapiens_hsa005650.07606248
97N-Glycan biosynthesis_Homo sapiens_hsa005100.07171114
98Nicotine addiction_Homo sapiens_hsa050330.07034486
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.06650487
100Phagosome_Homo sapiens_hsa041450.06553872

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