Rank | Gene Set | Z-score |
---|---|---|
1 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 7.50409884 |
2 | actin nucleation (GO:0045010) | 6.62897829 |
3 | positive thymic T cell selection (GO:0045059) | 5.77766225 |
4 | negative regulation by host of viral transcription (GO:0043922) | 5.77254837 |
5 | positive T cell selection (GO:0043368) | 5.55529092 |
6 | eosinophil chemotaxis (GO:0048245) | 5.48247202 |
7 | positive regulation of interleukin-8 secretion (GO:2000484) | 5.12431167 |
8 | pyrimidine nucleoside catabolic process (GO:0046135) | 5.08080862 |
9 | positive regulation of tolerance induction (GO:0002645) | 5.05392114 |
10 | T cell migration (GO:0072678) | 5.01717179 |
11 | eosinophil migration (GO:0072677) | 4.95810869 |
12 | positive regulation of natural killer cell mediated immunity (GO:0002717) | 4.94892568 |
13 | negative regulation of T cell apoptotic process (GO:0070233) | 4.94674793 |
14 | regulation of activation of Janus kinase activity (GO:0010533) | 4.93976679 |
15 | regulation of T cell tolerance induction (GO:0002664) | 4.92132934 |
16 | positive regulation of natural killer cell mediated cytotoxicity (GO:0045954) | 4.90446347 |
17 | negative regulation of viral genome replication (GO:0045071) | 4.81811008 |
18 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 4.70173156 |
19 | regulation of lymphocyte chemotaxis (GO:1901623) | 4.62667219 |
20 | cellular response to interleukin-15 (GO:0071350) | 4.62584358 |
21 | cytolysis (GO:0019835) | 4.60065820 |
22 | negative T cell selection (GO:0043383) | 4.57374832 |
23 | thymic T cell selection (GO:0045061) | 4.56892183 |
24 | positive regulation of calcium-mediated signaling (GO:0050850) | 4.53080809 |
25 | regulation of regulatory T cell differentiation (GO:0045589) | 4.38988510 |
26 | positive regulation of gamma-delta T cell activation (GO:0046645) | 4.29496359 |
27 | macrophage chemotaxis (GO:0048246) | 4.27695416 |
28 | regulation of natural killer cell mediated immunity (GO:0002715) | 4.25033384 |
29 | regulation of natural killer cell mediated cytotoxicity (GO:0042269) | 4.25033384 |
30 | positive regulation of monocyte chemotaxis (GO:0090026) | 4.20367018 |
31 | regulation of gamma-delta T cell differentiation (GO:0045586) | 4.07853023 |
32 | positive regulation of leukocyte mediated cytotoxicity (GO:0001912) | 4.04151109 |
33 | regulation of tolerance induction (GO:0002643) | 4.00603340 |
34 | regulation of T cell chemotaxis (GO:0010819) | 3.98673958 |
35 | positive regulation of T cell chemotaxis (GO:0010820) | 3.98673958 |
36 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 3.98418081 |
37 | positive regulation of lymphocyte migration (GO:2000403) | 3.93047023 |
38 | regulation of B cell receptor signaling pathway (GO:0050855) | 3.92410380 |
39 | T cell selection (GO:0045058) | 3.90432474 |
40 | response to interleukin-15 (GO:0070672) | 3.89070572 |
41 | regulation of chronic inflammatory response (GO:0002676) | 3.89003463 |
42 | sequestering of actin monomers (GO:0042989) | 3.88641815 |
43 | regulation of interleukin-8 secretion (GO:2000482) | 3.80242772 |
44 | positive regulation of B cell differentiation (GO:0045579) | 3.78344757 |
45 | negative thymic T cell selection (GO:0045060) | 3.75670078 |
46 | T cell costimulation (GO:0031295) | 3.72966128 |
47 | lymphocyte chemotaxis (GO:0048247) | 3.72761497 |
48 | lymphocyte costimulation (GO:0031294) | 3.68286350 |
49 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 3.66867240 |
50 | monocyte chemotaxis (GO:0002548) | 3.65716067 |
51 | regulation of interleukin-2 biosynthetic process (GO:0045076) | 3.58892233 |
52 | positive regulation of cell killing (GO:0031343) | 3.57265477 |
53 | negative regulation of lymphocyte apoptotic process (GO:0070229) | 3.49962141 |
54 | regulation of viral genome replication (GO:0045069) | 3.49413655 |
55 | regulation of leukocyte mediated cytotoxicity (GO:0001910) | 3.47543473 |
56 | positive regulation of interleukin-4 production (GO:0032753) | 3.46802173 |
57 | T cell receptor signaling pathway (GO:0050852) | 3.46612587 |
58 | positive regulation of translational initiation (GO:0045948) | 3.46537365 |
59 | positive regulation of uterine smooth muscle contraction (GO:0070474) | 3.45843964 |
60 | regulation of B cell differentiation (GO:0045577) | 3.44408105 |
61 | regulation of T cell receptor signaling pathway (GO:0050856) | 3.41644631 |
62 | positive regulation of defense response to virus by host (GO:0002230) | 3.40186026 |
63 | DNA demethylation (GO:0080111) | 3.39246546 |
64 | regulation of gamma-delta T cell activation (GO:0046643) | 3.35483215 |
65 | modulation by host of viral transcription (GO:0043921) | 3.35094796 |
66 | modulation by host of symbiont transcription (GO:0052472) | 3.35094796 |
67 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.33084848 |
68 | antigen processing and presentation via MHC class Ib (GO:0002475) | 3.31464030 |
69 | negative regulation of antigen receptor-mediated signaling pathway (GO:0050858) | 3.30450965 |
70 | regulation of calcium-mediated signaling (GO:0050848) | 3.26150245 |
71 | iron-sulfur cluster assembly (GO:0016226) | 3.23233231 |
72 | metallo-sulfur cluster assembly (GO:0031163) | 3.23233231 |
73 | modulation of transcription in other organism involved in symbiotic interaction (GO:0052312) | 3.21831469 |
74 | negative regulation of B cell proliferation (GO:0030889) | 3.18044357 |
75 | negative regulation of viral transcription (GO:0032897) | 3.16694151 |
76 | regulation of cell killing (GO:0031341) | 3.16159881 |
77 | regulation of antigen receptor-mediated signaling pathway (GO:0050854) | 3.15303008 |
78 | negative regulation of viral process (GO:0048525) | 3.13418065 |
79 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.13035129 |
80 | positive regulation of T cell apoptotic process (GO:0070234) | 3.08947057 |
81 | positive regulation of T cell mediated cytotoxicity (GO:0001916) | 3.08541253 |
82 | positive regulation of alpha-beta T cell proliferation (GO:0046641) | 3.07243414 |
83 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.06607915 |
84 | lymphocyte migration (GO:0072676) | 3.06031079 |
85 | response to interferon-beta (GO:0035456) | 3.02711799 |
86 | regulation of chemokine-mediated signaling pathway (GO:0070099) | 3.02131925 |
87 | antigen receptor-mediated signaling pathway (GO:0050851) | 3.00157249 |
88 | pyrimidine-containing compound catabolic process (GO:0072529) | 2.99890979 |
89 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 2.99230249 |
90 | chemokine-mediated signaling pathway (GO:0070098) | 2.97714276 |
91 | protein neddylation (GO:0045116) | 2.97424906 |
92 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 2.97325653 |
93 | regulation of T cell apoptotic process (GO:0070232) | 2.96746131 |
94 | regulation of alpha-beta T cell proliferation (GO:0046640) | 2.96511438 |
95 | cytidine catabolic process (GO:0006216) | 11.5491207 |
96 | cytidine deamination (GO:0009972) | 11.5491207 |
97 | cytidine metabolic process (GO:0046087) | 11.5491207 |
98 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 10.2065216 |
99 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 10.1592071 |
100 | DNA deamination (GO:0045006) | 10.1300223 |
Rank | Gene Set | Z-score |
---|---|---|
1 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 9.72197400 |
2 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 5.09984973 |
3 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 4.34067796 |
4 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 4.26419641 |
5 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 4.12822991 |
6 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 3.51531267 |
7 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 3.36636777 |
8 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 3.11147448 |
9 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 3.10928873 |
10 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 2.94385354 |
11 | MYB_26560356_Chip-Seq_TH2_Human | 2.82023997 |
12 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 2.57479095 |
13 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.26478067 |
14 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 2.21734488 |
15 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 2.15351058 |
16 | RUNX_20019798_ChIP-Seq_JUKART_Human | 2.10559247 |
17 | GATA3_27048872_Chip-Seq_THYMUS_Human | 2.10216451 |
18 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.97339186 |
19 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.89910743 |
20 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 1.82934179 |
21 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.80427903 |
22 | MYB_26560356_Chip-Seq_TH1_Human | 1.80090275 |
23 | GATA3_26560356_Chip-Seq_TH2_Human | 1.79196550 |
24 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 1.64174402 |
25 | VDR_22108803_ChIP-Seq_LS180_Human | 1.63187944 |
26 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.60934797 |
27 | UTX_26944678_Chip-Seq_JUKART_Human | 1.58205291 |
28 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.57108278 |
29 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 1.54778313 |
30 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 1.54111682 |
31 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.47762106 |
32 | MAF_26560356_Chip-Seq_TH2_Human | 1.44670132 |
33 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 1.44110766 |
34 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.44099435 |
35 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.42265646 |
36 | MAF_26560356_Chip-Seq_TH1_Human | 1.41599069 |
37 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.35950834 |
38 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 1.35712327 |
39 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.35043238 |
40 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.34350030 |
41 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 1.34188113 |
42 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.33458102 |
43 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.26570829 |
44 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.26271577 |
45 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 1.25971560 |
46 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.25710540 |
47 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 1.21747178 |
48 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 1.20968539 |
49 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.20252146 |
50 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 1.18681685 |
51 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.17616570 |
52 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 1.17011459 |
53 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.15439504 |
54 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 1.15389311 |
55 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.12366997 |
56 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 1.12212099 |
57 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.09514218 |
58 | GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.08504912 |
59 | TAF2_19829295_ChIP-Seq_ESCs_Human | 1.08459211 |
60 | NCOR_22424771_ChIP-Seq_293T_Human | 1.05560168 |
61 | AR_20517297_ChIP-Seq_VCAP_Human | 1.02167667 |
62 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.01704681 |
63 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.01598675 |
64 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.01171956 |
65 | NANOG_20526341_ChIP-Seq_ESCs_Human | 0.99736655 |
66 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 0.99376504 |
67 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 0.99235169 |
68 | CTCF_20526341_ChIP-Seq_ESCs_Human | 0.98467220 |
69 | GATA6_21074721_ChIP-Seq_CACO-2_Mouse | 0.95176861 |
70 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 0.93106368 |
71 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 0.90270114 |
72 | GATA3_26560356_Chip-Seq_TH1_Human | 0.89781701 |
73 | CIITA_25753668_ChIP-Seq_RAJI_Human | 0.89572555 |
74 | BMI1_19503595_ChIP-Seq_MEFsC_Mouse | 0.89024172 |
75 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 0.88768305 |
76 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 0.87941829 |
77 | FOXP3_21729870_ChIP-Seq_TREG_Human | 0.86987841 |
78 | STAT1_20625510_ChIP-Seq_HELA_Human | 0.86445986 |
79 | RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.85525736 |
80 | EBNA1_20929547_Chip-Seq_RAJI-cells_Human | 0.85279682 |
81 | SA1_27219007_Chip-Seq_Bcells_Human | 0.84486047 |
82 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.84310246 |
83 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.84310246 |
84 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.84016022 |
85 | P300_27268052_Chip-Seq_Bcells_Human | 0.82241394 |
86 | GATA6_21074721_ChIP-Seq_CACO-2_Human | 0.81291275 |
87 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.80883375 |
88 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 0.80874373 |
89 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.79793942 |
90 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.79369015 |
91 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.79369015 |
92 | MYC_19829295_ChIP-Seq_ESCs_Human | 0.78710889 |
93 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.78300827 |
94 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 0.77537228 |
95 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 0.77338300 |
96 | RBPJ_21746931_ChIP-Seq_IB4_Human | 0.76571748 |
97 | TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.76543592 |
98 | TAF15_26573619_Chip-Seq_HEK293_Human | 0.76408785 |
99 | FOXH1_21741376_ChIP-Seq_ESCs_Human | 0.75385984 |
100 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 0.74239190 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0005671_abnormal_response_to | 6.92185590 |
2 | MP0009785_altered_susceptibility_to | 4.15394448 |
3 | MP0001835_abnormal_antigen_presentation | 3.31204218 |
4 | MP0003763_abnormal_thymus_physiology | 3.30465636 |
5 | MP0009333_abnormal_splenocyte_physiolog | 2.89603523 |
6 | MP0003045_fibrosis | 2.79322349 |
7 | MP0002166_altered_tumor_susceptibility | 2.76964676 |
8 | MP0005025_abnormal_response_to | 2.63126259 |
9 | MP0006082_CNS_inflammation | 2.57917938 |
10 | MP0005000_abnormal_immune_tolerance | 2.56270907 |
11 | MP0003866_abnormal_defecation | 2.50140274 |
12 | MP0001873_stomach_inflammation | 2.45955606 |
13 | MP0001800_abnormal_humoral_immune | 2.44074433 |
14 | MP0005377_hearing/vestibular/ear_phenot | 2.39756089 |
15 | MP0003878_abnormal_ear_physiology | 2.39756089 |
16 | MP0002420_abnormal_adaptive_immunity | 2.37707259 |
17 | MP0002148_abnormal_hypersensitivity_rea | 2.36812055 |
18 | MP0002723_abnormal_immune_serum | 2.32074969 |
19 | MP0001819_abnormal_immune_cell | 2.28797852 |
20 | MP0005387_immune_system_phenotype | 2.25680464 |
21 | MP0001790_abnormal_immune_system | 2.25680464 |
22 | MP0003448_altered_tumor_morphology | 2.20021315 |
23 | MP0002006_tumorigenesis | 2.19562232 |
24 | MP0000685_abnormal_immune_system | 2.06870994 |
25 | MP0004147_increased_porphyrin_level | 2.06079602 |
26 | MP0002102_abnormal_ear_morphology | 2.03094735 |
27 | MP0010155_abnormal_intestine_physiology | 1.91739365 |
28 | MP0002452_abnormal_antigen_presenting | 1.87130815 |
29 | MP0000716_abnormal_immune_system | 1.87123587 |
30 | MP0002398_abnormal_bone_marrow | 1.84646803 |
31 | MP0002405_respiratory_system_inflammati | 1.74345524 |
32 | MP0003786_premature_aging | 1.69788386 |
33 | MP0001853_heart_inflammation | 1.69044741 |
34 | MP0002722_abnormal_immune_system | 1.67361863 |
35 | MP0000703_abnormal_thymus_morphology | 1.64388487 |
36 | MP0000689_abnormal_spleen_morphology | 1.51302011 |
37 | MP0001845_abnormal_inflammatory_respons | 1.50966449 |
38 | MP0001188_hyperpigmentation | 1.48239700 |
39 | MP0002933_joint_inflammation | 1.45771324 |
40 | MP0004381_abnormal_hair_follicle | 1.42792194 |
41 | MP0002429_abnormal_blood_cell | 1.41707518 |
42 | MP0004145_abnormal_muscle_electrophysio | 1.38547315 |
43 | MP0002419_abnormal_innate_immunity | 1.34342416 |
44 | MP0000569_abnormal_digit_pigmentation | 1.34128108 |
45 | MP0002837_dystrophic_cardiac_calcinosis | 1.32786041 |
46 | MP0002653_abnormal_ependyma_morphology | 1.32609387 |
47 | MP0002138_abnormal_hepatobiliary_system | 1.29626508 |
48 | MP0006054_spinal_hemorrhage | 1.23668085 |
49 | MP0005075_abnormal_melanosome_morpholog | 1.20681485 |
50 | MP0002877_abnormal_melanocyte_morpholog | 1.18607560 |
51 | MP0003806_abnormal_nucleotide_metabolis | 1.14127507 |
52 | MP0009763_increased_sensitivity_to | 1.13444907 |
53 | MP0004947_skin_inflammation | 1.12351734 |
54 | MP0008469_abnormal_protein_level | 1.10861653 |
55 | MP0001661_extended_life_span | 1.08315124 |
56 | MP0000858_altered_metastatic_potential | 1.05540902 |
57 | MP0005464_abnormal_platelet_physiology | 1.04271067 |
58 | MP0004134_abnormal_chest_morphology | 1.01721511 |
59 | MP0002095_abnormal_skin_pigmentation | 1.01515520 |
60 | MP0003137_abnormal_impulse_conducting | 0.99386321 |
61 | MP0003646_muscle_fatigue | 0.98929752 |
62 | MP0005310_abnormal_salivary_gland | 0.98532167 |
63 | MP0001905_abnormal_dopamine_level | 0.97441221 |
64 | MP0003436_decreased_susceptibility_to | 0.92726406 |
65 | MP0005645_abnormal_hypothalamus_physiol | 0.92193897 |
66 | MP0002019_abnormal_tumor_incidence | 0.87318408 |
67 | MP0002168_other_aberrant_phenotype | 0.86149320 |
68 | MP0001485_abnormal_pinna_reflex | 0.86146857 |
69 | MP0001968_abnormal_touch/_nociception | 0.85126474 |
70 | MP0002876_abnormal_thyroid_physiology | 0.84058599 |
71 | MP0005166_decreased_susceptibility_to | 0.83613817 |
72 | MP0008873_increased_physiological_sensi | 0.82323246 |
73 | MP0002163_abnormal_gland_morphology | 0.80591092 |
74 | MP0009764_decreased_sensitivity_to | 0.79025198 |
75 | MP0006072_abnormal_retinal_apoptosis | 0.78708627 |
76 | MP0003011_delayed_dark_adaptation | 0.77385904 |
77 | MP0000372_irregular_coat_pigmentation | 0.75808908 |
78 | MP0005551_abnormal_eye_electrophysiolog | 0.75684207 |
79 | MP0003136_yellow_coat_color | 0.75568083 |
80 | MP0000749_muscle_degeneration | 0.75533532 |
81 | MP0003075_altered_response_to | 0.73006366 |
82 | MP0002693_abnormal_pancreas_physiology | 0.72466384 |
83 | MP0003195_calcinosis | 0.69455171 |
84 | MP0005174_abnormal_tail_pigmentation | 0.66495412 |
85 | MP0001243_abnormal_dermal_layer | 0.65493962 |
86 | MP0009643_abnormal_urine_homeostasis | 0.63453104 |
87 | MP0005389_reproductive_system_phenotype | 0.63333741 |
88 | MP0009765_abnormal_xenobiotic_induced | 0.63059522 |
89 | MP0001984_abnormal_olfaction | 0.62801195 |
90 | MP0001542_abnormal_bone_strength | 0.62181367 |
91 | MP0001919_abnormal_reproductive_system | 0.61695862 |
92 | MP0005330_cardiomyopathy | 0.61214091 |
93 | MP0002736_abnormal_nociception_after | 0.60502031 |
94 | MP0002136_abnormal_kidney_physiology | 0.57732221 |
95 | MP0003567_abnormal_fetal_cardiomyocyte | 0.56695380 |
96 | MP0005636_abnormal_mineral_homeostasis | 0.54592822 |
97 | MP0006036_abnormal_mitochondrial_physio | 0.54155740 |
98 | MP0001533_abnormal_skeleton_physiology | 0.53334170 |
99 | MP0003252_abnormal_bile_duct | 0.53308295 |
100 | MP0005379_endocrine/exocrine_gland_phen | 0.52826550 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Aplastic anemia (HP:0001915) | 7.30843791 |
2 | T lymphocytopenia (HP:0005403) | 7.01820948 |
3 | Abnormality of T cell number (HP:0011839) | 6.68849322 |
4 | Autoimmune hemolytic anemia (HP:0001890) | 5.18331260 |
5 | Elevated erythrocyte sedimentation rate (HP:0003565) | 4.96317150 |
6 | Hypoproteinemia (HP:0003075) | 4.76041579 |
7 | Increased IgM level (HP:0003496) | 4.69016676 |
8 | IgG deficiency (HP:0004315) | 4.65355452 |
9 | Abnormality of T cells (HP:0002843) | 4.37878764 |
10 | Severe combined immunodeficiency (HP:0004430) | 4.10114975 |
11 | Abnormality of the prostate (HP:0008775) | 4.00698441 |
12 | Chronic diarrhea (HP:0002028) | 3.57631999 |
13 | Thyroiditis (HP:0100646) | 3.43651894 |
14 | Recurrent bronchitis (HP:0002837) | 3.31086911 |
15 | Stomatitis (HP:0010280) | 3.24882941 |
16 | Abnormality of eosinophils (HP:0001879) | 3.24064277 |
17 | Combined immunodeficiency (HP:0005387) | 3.21036784 |
18 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.20983140 |
19 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.20983140 |
20 | Amyotrophic lateral sclerosis (HP:0007354) | 3.16892782 |
21 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 3.15012001 |
22 | Renal Fanconi syndrome (HP:0001994) | 3.14467234 |
23 | Generalized aminoaciduria (HP:0002909) | 3.12684164 |
24 | Increased intramyocellular lipid droplets (HP:0012240) | 3.11183084 |
25 | Lymphopenia (HP:0001888) | 3.02621685 |
26 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 2.92831460 |
27 | Mitochondrial inheritance (HP:0001427) | 2.85604138 |
28 | Abnormality of macrophages (HP:0004311) | 2.81711687 |
29 | Meningitis (HP:0001287) | 2.78577360 |
30 | Gangrene (HP:0100758) | 2.70950224 |
31 | Obstructive lung disease (HP:0006536) | 2.67205603 |
32 | Chronic obstructive pulmonary disease (HP:0006510) | 2.67205603 |
33 | Pulmonary infiltrates (HP:0002113) | 2.64674069 |
34 | Autoimmune thrombocytopenia (HP:0001973) | 2.62173537 |
35 | Eosinophilia (HP:0001880) | 2.60047551 |
36 | 3-Methylglutaconic aciduria (HP:0003535) | 2.52622532 |
37 | Encephalitis (HP:0002383) | 2.52324895 |
38 | Hypoalbuminemia (HP:0003073) | 2.51721704 |
39 | Abnormal albumin level (HP:0012116) | 2.51721704 |
40 | Recurrent cutaneous fungal infections (HP:0011370) | 2.49572949 |
41 | Chronic mucocutaneous candidiasis (HP:0002728) | 2.49572949 |
42 | Increased muscle lipid content (HP:0009058) | 2.49442233 |
43 | Ureteral stenosis (HP:0000071) | 2.49252288 |
44 | Pancytopenia (HP:0001876) | 2.48597907 |
45 | Joint swelling (HP:0001386) | 2.47901995 |
46 | Congenital stationary night blindness (HP:0007642) | 2.41841855 |
47 | Leukocytosis (HP:0001974) | 2.41382529 |
48 | Hemoptysis (HP:0002105) | 2.39140008 |
49 | Bronchitis (HP:0012387) | 2.38516939 |
50 | IgM deficiency (HP:0002850) | 2.36302471 |
51 | Hepatocellular necrosis (HP:0001404) | 2.32437785 |
52 | Chest pain (HP:0100749) | 2.32338723 |
53 | Recurrent otitis media (HP:0000403) | 2.32329827 |
54 | Abnormality of the pleura (HP:0002103) | 2.31639377 |
55 | Abnormality of male internal genitalia (HP:0000022) | 2.30702873 |
56 | Myositis (HP:0100614) | 2.30679118 |
57 | Hypergammaglobulinemia (HP:0010702) | 2.29280436 |
58 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 2.25794202 |
59 | Abnormality of T cell physiology (HP:0011840) | 2.24910988 |
60 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.23097772 |
61 | Acute necrotizing encephalopathy (HP:0006965) | 2.22265668 |
62 | Recurrent viral infections (HP:0004429) | 2.22112015 |
63 | Ureteral obstruction (HP:0006000) | 2.21695626 |
64 | Pustule (HP:0200039) | 2.17417890 |
65 | Increased CSF lactate (HP:0002490) | 2.16302008 |
66 | Vasculitis (HP:0002633) | 2.15251577 |
67 | Increased hepatocellular lipid droplets (HP:0006565) | 2.12636611 |
68 | IgA deficiency (HP:0002720) | 2.12586960 |
69 | Radial bowing (HP:0002986) | 2.12223451 |
70 | Pulmonary embolism (HP:0002204) | 2.11865892 |
71 | Lymphoma (HP:0002665) | 2.11424241 |
72 | Recurrent fungal infections (HP:0002841) | 2.10566214 |
73 | Hepatic necrosis (HP:0002605) | 2.07332177 |
74 | Prostate neoplasm (HP:0100787) | 2.06964784 |
75 | Granulocytopenia (HP:0001913) | 2.05511546 |
76 | Hemiplegia (HP:0002301) | 2.04740056 |
77 | Oral leukoplakia (HP:0002745) | 2.04399156 |
78 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 1.99688606 |
79 | Pigmentary retinal degeneration (HP:0001146) | 1.99602867 |
80 | Purpura (HP:0000979) | 1.97053489 |
81 | Decreased central vision (HP:0007663) | 1.96851033 |
82 | Abnormal rod and cone electroretinograms (HP:0008323) | 1.96472642 |
83 | Retrobulbar optic neuritis (HP:0100654) | 1.95795882 |
84 | Optic neuritis (HP:0100653) | 1.95795882 |
85 | Pancreatic cysts (HP:0001737) | 1.95211343 |
86 | Hypoplasia of the thymus (HP:0000778) | 1.94074366 |
87 | Agammaglobulinemia (HP:0004432) | 1.90608128 |
88 | Cerebral palsy (HP:0100021) | 1.87980676 |
89 | Abolished electroretinogram (ERG) (HP:0000550) | 1.87797060 |
90 | Gastrointestinal infarctions (HP:0005244) | 1.86424649 |
91 | Spastic paraparesis (HP:0002313) | 1.85978690 |
92 | Progressive macrocephaly (HP:0004481) | 1.83432292 |
93 | Petechiae (HP:0000967) | 1.81597909 |
94 | Pulmonary fibrosis (HP:0002206) | 1.79710799 |
95 | Abnormal drinking behavior (HP:0030082) | 1.79454330 |
96 | Polydipsia (HP:0001959) | 1.79454330 |
97 | Abnormality of B cell number (HP:0010975) | 1.75753821 |
98 | Abnormality of the pericardium (HP:0001697) | 1.74695045 |
99 | Recurrent skin infections (HP:0001581) | 1.73616071 |
100 | Lipid accumulation in hepatocytes (HP:0006561) | 1.73396575 |
Rank | Gene Set | Z-score |
---|---|---|
1 | TXK | 7.94059804 |
2 | KDR | 6.75013957 |
3 | TESK2 | 5.18870359 |
4 | MAP4K1 | 2.79852086 |
5 | TESK1 | 2.52128424 |
6 | VRK2 | 2.51632280 |
7 | ITK | 2.50192705 |
8 | BUB1 | 2.34443318 |
9 | LIMK1 | 2.28222207 |
10 | ADRBK2 | 2.07217020 |
11 | BCKDK | 1.90522978 |
12 | FES | 1.68789531 |
13 | PIK3CA | 1.68521414 |
14 | ZAK | 1.65986047 |
15 | SYK | 1.63010600 |
16 | CSK | 1.61865787 |
17 | MUSK | 1.55800141 |
18 | MAPKAPK3 | 1.54808449 |
19 | STK16 | 1.53712905 |
20 | TAOK3 | 1.49296972 |
21 | FRK | 1.48948803 |
22 | PRKCQ | 1.38153115 |
23 | MAP3K12 | 1.35172812 |
24 | LCK | 1.34228263 |
25 | EIF2AK3 | 1.26816309 |
26 | GRK1 | 1.24918792 |
27 | GRK7 | 1.24301833 |
28 | SCYL2 | 1.19298382 |
29 | ZAP70 | 1.16172742 |
30 | TEC | 1.11387882 |
31 | BTK | 1.07457452 |
32 | VRK1 | 1.03059569 |
33 | IKBKE | 1.00682633 |
34 | BLK | 1.00210444 |
35 | LYN | 0.88629110 |
36 | IKBKB | 0.88086367 |
37 | WNK4 | 0.87351503 |
38 | JAK3 | 0.85643484 |
39 | CSF1R | 0.85510716 |
40 | TLK1 | 0.84728379 |
41 | MAP2K6 | 0.81579738 |
42 | TBK1 | 0.80204210 |
43 | MAP3K11 | 0.77102738 |
44 | TIE1 | 0.69350348 |
45 | ROCK1 | 0.68706158 |
46 | DAPK1 | 0.67362316 |
47 | FYN | 0.66008237 |
48 | MYLK | 0.62043647 |
49 | IGF1R | 0.58525352 |
50 | CLK1 | 0.57546359 |
51 | OXSR1 | 0.55093883 |
52 | GRK6 | 0.52386809 |
53 | MST4 | 0.50486152 |
54 | INSRR | 0.49457534 |
55 | GRK5 | 0.48888160 |
56 | PIK3CG | 0.47140234 |
57 | MAPKAPK5 | 0.45656177 |
58 | INSR | 0.45262912 |
59 | ADRBK1 | 0.42693014 |
60 | TGFBR2 | 0.41758913 |
61 | OBSCN | 0.41261781 |
62 | PAK1 | 0.40659301 |
63 | MATK | 0.39648392 |
64 | JAK2 | 0.36371158 |
65 | MAPKAPK2 | 0.36268322 |
66 | TNK2 | 0.35722708 |
67 | MAPK11 | 0.34597412 |
68 | MAP3K5 | 0.34141885 |
69 | PRKCA | 0.33918939 |
70 | RPS6KA5 | 0.33875115 |
71 | CAMK2A | 0.33849210 |
72 | NUAK1 | 0.33024507 |
73 | PIM2 | 0.32963736 |
74 | MAPK13 | 0.32132151 |
75 | RIPK4 | 0.31730233 |
76 | AURKA | 0.31332783 |
77 | BMPR2 | 0.27982614 |
78 | STK38L | 0.27791170 |
79 | TYRO3 | 0.25364717 |
80 | PIM1 | 0.25078034 |
81 | HCK | 0.23979648 |
82 | NME1 | 0.22517180 |
83 | LATS1 | 0.22176670 |
84 | TRIM28 | 0.21958955 |
85 | PRKACA | 0.21273401 |
86 | DAPK3 | 0.21102626 |
87 | PINK1 | 0.20354739 |
88 | CSNK1G3 | 0.19749121 |
89 | WNK3 | 0.18772883 |
90 | TRPM7 | 0.18071787 |
91 | PASK | 0.17948162 |
92 | NEK2 | 0.17568524 |
93 | ABL1 | 0.17437185 |
94 | CSNK2A1 | 0.16840354 |
95 | SRC | 0.16716644 |
96 | STK10 | 0.16697948 |
97 | PRKCB | 0.16323617 |
98 | CSNK1A1L | 0.15764623 |
99 | SRPK1 | 0.14384925 |
100 | ATR | 0.14170740 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Primary immunodeficiency_Homo sapiens_hsa05340 | 6.24695483 |
2 | Proteasome_Homo sapiens_hsa03050 | 4.88682668 |
3 | Graft-versus-host disease_Homo sapiens_hsa05332 | 4.03669310 |
4 | Antigen processing and presentation_Homo sapiens_hsa04612 | 3.85012344 |
5 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 3.60884232 |
6 | Allograft rejection_Homo sapiens_hsa05330 | 3.19215339 |
7 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 3.04558230 |
8 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 2.89500336 |
9 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 2.81204214 |
10 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 2.69951333 |
11 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.57843119 |
12 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 2.44208009 |
13 | Parkinsons disease_Homo sapiens_hsa05012 | 2.21578050 |
14 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 2.20586129 |
15 | Salmonella infection_Homo sapiens_hsa05132 | 1.61763547 |
16 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 1.56288205 |
17 | Measles_Homo sapiens_hsa05162 | 1.55159404 |
18 | Alzheimers disease_Homo sapiens_hsa05010 | 1.46548506 |
19 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 1.44920250 |
20 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.44244809 |
21 | Viral myocarditis_Homo sapiens_hsa05416 | 1.42792942 |
22 | Asthma_Homo sapiens_hsa05310 | 1.40908250 |
23 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.38079113 |
24 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 1.34132216 |
25 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.30816629 |
26 | Shigellosis_Homo sapiens_hsa05131 | 1.26593406 |
27 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.18770857 |
28 | RNA polymerase_Homo sapiens_hsa03020 | 1.18495027 |
29 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.17692216 |
30 | Malaria_Homo sapiens_hsa05144 | 1.16119161 |
31 | Protein export_Homo sapiens_hsa03060 | 1.13407323 |
32 | Huntingtons disease_Homo sapiens_hsa05016 | 1.12194316 |
33 | Phototransduction_Homo sapiens_hsa04744 | 1.06580066 |
34 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.04775012 |
35 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 1.01980902 |
36 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.95437453 |
37 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.93357217 |
38 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.92266266 |
39 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.92008781 |
40 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.81242774 |
41 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.79555020 |
42 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.78384643 |
43 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.76441107 |
44 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.75784927 |
45 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.71873149 |
46 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.66893357 |
47 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.65395333 |
48 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.62730826 |
49 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.60311463 |
50 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.59615833 |
51 | Peroxisome_Homo sapiens_hsa04146 | 0.56153663 |
52 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.54615823 |
53 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.54425740 |
54 | HTLV-I infection_Homo sapiens_hsa05166 | 0.49010137 |
55 | Homologous recombination_Homo sapiens_hsa03440 | 0.42675207 |
56 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.41758736 |
57 | Prion diseases_Homo sapiens_hsa05020 | 0.41538061 |
58 | Ribosome_Homo sapiens_hsa03010 | 0.39231936 |
59 | Leishmaniasis_Homo sapiens_hsa05140 | 0.39207390 |
60 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.38667764 |
61 | Pertussis_Homo sapiens_hsa05133 | 0.34204097 |
62 | Apoptosis_Homo sapiens_hsa04210 | 0.33949162 |
63 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.32863564 |
64 | Legionellosis_Homo sapiens_hsa05134 | 0.32688281 |
65 | Retinol metabolism_Homo sapiens_hsa00830 | 0.29513638 |
66 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.29483026 |
67 | Olfactory transduction_Homo sapiens_hsa04740 | 0.29416089 |
68 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.26476611 |
69 | Influenza A_Homo sapiens_hsa05164 | 0.26385650 |
70 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.26381940 |
71 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.26155535 |
72 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.24252275 |
73 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.23386094 |
74 | Osteoclast differentiation_Homo sapiens_hsa04380 | 0.23000105 |
75 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.21614096 |
76 | Purine metabolism_Homo sapiens_hsa00230 | 0.19569537 |
77 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.19304494 |
78 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.17650389 |
79 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.17130894 |
80 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.16883643 |
81 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.16138833 |
82 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.15455668 |
83 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.15404019 |
84 | Taste transduction_Homo sapiens_hsa04742 | 0.15399256 |
85 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.15262857 |
86 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.15069817 |
87 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.14414434 |
88 | ABC transporters_Homo sapiens_hsa02010 | 0.13232561 |
89 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.12861037 |
90 | Morphine addiction_Homo sapiens_hsa05032 | 0.12706143 |
91 | Endocytosis_Homo sapiens_hsa04144 | 0.12099836 |
92 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.11682159 |
93 | Tuberculosis_Homo sapiens_hsa05152 | 0.10725633 |
94 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.10449179 |
95 | RNA degradation_Homo sapiens_hsa03018 | 0.10057744 |
96 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.07606248 |
97 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.07171114 |
98 | Nicotine addiction_Homo sapiens_hsa05033 | 0.07034486 |
99 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.06650487 |
100 | Phagosome_Homo sapiens_hsa04145 | 0.06553872 |