PRR14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene tethers heterochromatin to the nuclear laminar scaffold by binding heterochromatin protein 1 (HP1) and the nuclear lamina. The tether is broken during mitosis and reforms quickly after mitosis, with the encoded protein first binding HP1 and then attaching to the nuclear lamina. This protein also has been shown to promote MyoD activity and skeletal myogenesis. Two transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of type I interferon-mediated signaling pathway (GO:0060340)6.06583743
2positive regulation by symbiont of host defense response (GO:0052509)4.74534916
3modulation by symbiont of host defense response (GO:0052031)4.74534916
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.74534916
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.74534916
6positive regulation by organism of defense response of other organism involved in symbiotic interact4.74534916
7modulation by symbiont of host immune response (GO:0052553)4.74534916
8positive regulation of gamma-delta T cell activation (GO:0046645)4.67833783
9cellular response to virus (GO:0098586)4.60843685
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.55156217
11antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.55156217
12antigen processing and presentation of endogenous antigen (GO:0019883)4.50967759
13positive thymic T cell selection (GO:0045059)4.49933794
14regulation of interferon-beta biosynthetic process (GO:0045357)4.42085648
15response to peptidoglycan (GO:0032494)4.35894905
16neutrophil activation involved in immune response (GO:0002283)4.20235317
17macrophage activation involved in immune response (GO:0002281)4.04932638
18regulation of gamma-delta T cell differentiation (GO:0045586)4.04806080
19NIK/NF-kappaB signaling (GO:0038061)4.04083755
20detection of bacterium (GO:0016045)3.87075534
21regulation of type I interferon-mediated signaling pathway (GO:0060338)3.85102934
22detection of other organism (GO:0098543)3.78600852
23regulation of gamma-delta T cell activation (GO:0046643)3.74810684
24positive regulation of interferon-alpha production (GO:0032727)3.71050545
25negative thymic T cell selection (GO:0045060)3.68983154
26response to type I interferon (GO:0034340)3.68818039
27antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.66053093
28negative T cell selection (GO:0043383)3.65273112
29regulation of mast cell degranulation (GO:0043304)3.60135564
30positive regulation of B cell differentiation (GO:0045579)3.57703035
31thymic T cell selection (GO:0045061)3.56955777
32type I interferon signaling pathway (GO:0060337)3.56059154
33cellular response to type I interferon (GO:0071357)3.56059154
34regulation of interferon-alpha production (GO:0032647)3.52334442
35immunoglobulin mediated immune response (GO:0016064)3.48955132
36regulation of interleukin-12 biosynthetic process (GO:0045075)3.48443055
37positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.41833526
38germinal center formation (GO:0002467)3.35142155
39regulation of T cell tolerance induction (GO:0002664)3.33465258
40regulation of leukocyte degranulation (GO:0043300)3.32978155
41regulation of myeloid leukocyte mediated immunity (GO:0002886)3.31971274
42positive T cell selection (GO:0043368)3.27708059
43regulation of B cell differentiation (GO:0045577)3.26409503
44leukocyte aggregation (GO:0070486)3.23179235
45signal complex assembly (GO:0007172)3.21046576
46regulation of B cell receptor signaling pathway (GO:0050855)3.20324595
47negative regulation of lymphocyte mediated immunity (GO:0002707)3.20018609
48T cell migration (GO:0072678)3.19814624
49negative regulation of leukocyte mediated immunity (GO:0002704)3.18507086
50antigen processing and presentation via MHC class Ib (GO:0002475)3.18141046
51regulation of mast cell activation involved in immune response (GO:0033006)3.15412836
52negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.15207660
53T cell selection (GO:0045058)3.14311769
54regulation of alpha-beta T cell proliferation (GO:0046640)3.10876018
55response to host immune response (GO:0052572)3.08355187
56response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.08355187
57granulocyte activation (GO:0036230)3.08248258
58B cell mediated immunity (GO:0019724)3.07270813
59detection of external biotic stimulus (GO:0098581)3.05115787
60interferon-gamma-mediated signaling pathway (GO:0060333)3.01364781
61cellular response to zinc ion (GO:0071294)2.97325572
62defense response to protozoan (GO:0042832)2.94625236
63response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.92585851
64response to host (GO:0075136)2.92585851
65response to host defenses (GO:0052200)2.92585851
66mannose metabolic process (GO:0006013)2.90481155
67megakaryocyte development (GO:0035855)2.88993188
68negative regulation of cell killing (GO:0031342)2.87083769
69negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.87083769
70response to interleukin-15 (GO:0070672)2.86608648
71modulation by virus of host process (GO:0019054)2.86495294
72regulation of response to interferon-gamma (GO:0060330)2.86114590
73negative regulation of T cell mediated immunity (GO:0002710)2.85695728
74negative regulation of granulocyte differentiation (GO:0030853)2.85343290
75regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.83271570
76myeloid cell activation involved in immune response (GO:0002275)2.81901549
77regulation of natural killer cell mediated immunity (GO:0002715)2.81794240
78regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.81794240
79regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.80082056
80modulation by symbiont of host cellular process (GO:0044068)2.78696100
81response to protozoan (GO:0001562)2.78620665
82cellular extravasation (GO:0045123)2.78487341
83regulation of regulated secretory pathway (GO:1903305)2.78297088
84positive regulation of cytokine-mediated signaling pathway (GO:0001961)2.77783343
85negative regulation of cytokine production involved in immune response (GO:0002719)2.77166910
86positive regulation of humoral immune response (GO:0002922)2.75192393
87positive regulation of interferon-beta production (GO:0032728)2.74740483
88positive regulation of tolerance induction (GO:0002645)2.69872400
89regulation of T-helper 2 cell differentiation (GO:0045628)2.69750708
90cellular response to interleukin-15 (GO:0071350)2.67347694
91regulation of antigen processing and presentation (GO:0002577)2.66797971
92positive regulation of alpha-beta T cell proliferation (GO:0046641)2.66553781
93positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.66247402
94positive regulation of response to cytokine stimulus (GO:0060760)2.66206359
95activation of MAPKKK activity (GO:0000185)2.65650003
96negative regulation of phagocytosis (GO:0050765)2.64900819
97regulation of dendritic cell antigen processing and presentation (GO:0002604)2.64787252
98detection of biotic stimulus (GO:0009595)2.64372534
99Peyers patch development (GO:0048541)2.63630918
100mucosal-associated lymphoid tissue development (GO:0048537)2.63630918
101regulation of defense response to virus by host (GO:0050691)2.62731926
102macrophage activation (GO:0042116)2.62254967
103negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.61919346
104respiratory burst (GO:0045730)2.60153169
105positive regulation of mast cell activation (GO:0033005)2.59442728
106regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.58420467
1073-UTR-mediated mRNA stabilization (GO:0070935)2.58360427
108regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.57030619
109regulation of tolerance induction (GO:0002643)2.53122061
110response to muramyl dipeptide (GO:0032495)2.51696175
111Arp2/3 complex-mediated actin nucleation (GO:0034314)2.50523236
112cellular response to dsRNA (GO:0071359)2.49368707
113B cell receptor signaling pathway (GO:0050853)2.49322795
114regulation of hypersensitivity (GO:0002883)2.49030862
115leukocyte cell-cell adhesion (GO:0007159)2.47572368
116regulation of monocyte differentiation (GO:0045655)2.46965201
117myeloid dendritic cell activation (GO:0001773)2.46772450
118regulation of T cell receptor signaling pathway (GO:0050856)2.46015575
119natural killer cell activation (GO:0030101)2.44861672
120DNA deamination (GO:0045006)2.42712534
121regulation of RIG-I signaling pathway (GO:0039535)2.41730342
122antigen receptor-mediated signaling pathway (GO:0050851)2.40403248
123interferon-gamma production (GO:0032609)2.39240217
124hepatocyte apoptotic process (GO:0097284)2.38805776
125myeloid dendritic cell differentiation (GO:0043011)2.36831920
126JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.36552140
127sequestering of actin monomers (GO:0042989)2.36386019
128negative regulation of type I interferon production (GO:0032480)2.35359792
129positive regulation of antigen processing and presentation (GO:0002579)2.34819237
130T cell receptor signaling pathway (GO:0050852)2.34699790
131cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)2.32663886
132tolerance induction (GO:0002507)2.32153984
133negative regulation of innate immune response (GO:0045824)2.32068156
134T cell costimulation (GO:0031295)2.31426042
135regulation of interferon-beta production (GO:0032648)2.31266275
136positive regulation of interleukin-2 production (GO:0032743)2.31212141
137regulation of necroptotic process (GO:0060544)2.28538339
138positive regulation of isotype switching (GO:0045830)2.27039487
139natural killer cell differentiation (GO:0001779)2.26749900
140lymphocyte costimulation (GO:0031294)2.25618691
141cytokine biosynthetic process (GO:0042089)2.23583897
142positive regulation of lamellipodium assembly (GO:0010592)2.22886184
143T cell homeostasis (GO:0043029)2.20517283
144lipopolysaccharide-mediated signaling pathway (GO:0031663)2.16113132
145negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.15750628
146neutrophil activation (GO:0042119)2.14429304
147negative regulation of erythrocyte differentiation (GO:0045647)2.14381812
148negative regulation of interleukin-12 production (GO:0032695)2.14215423
149cellular response to interferon-gamma (GO:0071346)2.14119339
150lymphocyte homeostasis (GO:0002260)2.13601303
151leukocyte apoptotic process (GO:0071887)2.13305774
152positive regulation of T cell differentiation in thymus (GO:0033089)2.13047037
153positive regulation of erythrocyte differentiation (GO:0045648)2.12667336

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.83387586
2E2F7_22180533_ChIP-Seq_HELA_Human3.80601661
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.15482903
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.95436546
5MYC_22102868_ChIP-Seq_BL_Human2.91572806
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.81819910
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.71622716
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.65308219
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.55882102
10VDR_21846776_ChIP-Seq_THP-1_Human2.50514089
11SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.45989850
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.44424465
13SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.15446710
14MAF_26560356_Chip-Seq_TH1_Human2.12838184
15UTX_26944678_Chip-Seq_JUKART_Human2.08122198
16SCL_19346495_ChIP-Seq_HPC-7_Human2.06926734
17STAT4_19710469_ChIP-ChIP_TH1__Mouse2.02546965
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.01836417
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.00312214
20MYB_26560356_Chip-Seq_TH2_Human1.97678146
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.95082766
22EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.92590905
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.87747089
24RACK7_27058665_Chip-Seq_MCF-7_Human1.83512322
25MYB_21317192_ChIP-Seq_ERMYB_Mouse1.80999181
26SPI1_23547873_ChIP-Seq_NB4_Human1.78552096
27* MYB_26560356_Chip-Seq_TH1_Human1.78534383
28ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.78212557
29FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.74382870
30NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.74149357
31SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.73744492
32FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.72493641
33TCF7_22412390_ChIP-Seq_EML_Mouse1.71197758
34E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.70411589
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.67578986
36STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.67490042
37* P68_20966046_ChIP-Seq_HELA_Human1.64899434
38BRD4_27068464_Chip-Seq_AML-cells_Mouse1.63263261
39IRF8_27001747_Chip-Seq_BMDM_Mouse1.63173534
40ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.62458272
41VDR_24763502_ChIP-Seq_THP-1_Human1.60350614
42CTCF_27219007_Chip-Seq_ERYTHROID_Human1.60048784
43ELK3_25401928_ChIP-Seq_HUVEC_Human1.56728455
44RUNX_20019798_ChIP-Seq_JUKART_Human1.55415900
45* SA1_27219007_Chip-Seq_ERYTHROID_Human1.55260153
46KDM2B_26808549_Chip-Seq_JURKAT_Human1.54550653
47* ELF1_20517297_ChIP-Seq_JURKAT_Human1.54429584
48VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.53306588
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.52194811
50MAF_26560356_Chip-Seq_TH2_Human1.51818340
51MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.50595257
52NOTCH1_21737748_ChIP-Seq_TLL_Human1.49527338
53STAT6_21828071_ChIP-Seq_BEAS2B_Human1.49160542
54FOXM1_23109430_ChIP-Seq_U2OS_Human1.47462129
55BCOR_27268052_Chip-Seq_Bcells_Human1.46732867
56EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46386898
57RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.46053208
58TET1_21451524_ChIP-Seq_MESCs_Mouse1.44732457
59BP1_19119308_ChIP-ChIP_Hs578T_Human1.43911655
60PPARA_22158963_ChIP-Seq_LIVER_Mouse1.43129694
61FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.42028937
62KDM2B_26808549_Chip-Seq_K562_Human1.41515475
63* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41418236
64GATA2_22383799_ChIP-Seq_G1ME_Mouse1.36612823
65SRY_22984422_ChIP-ChIP_TESTIS_Rat1.33941413
66TP63_17297297_ChIP-ChIP_HaCaT_Human1.30698621
67* CIITA_25753668_ChIP-Seq_RAJI_Human1.30438582
68GATA1_22383799_ChIP-Seq_G1ME_Mouse1.30336069
69* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.29179128
70* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.26935145
71* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.26265692
72SMC4_20622854_ChIP-Seq_HELA_Human1.26086181
73* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.25172402
74CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.24018458
75CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21909069
76LXR_22292898_ChIP-Seq_THP-1_Human1.21206110
77GATA3_27048872_Chip-Seq_THYMUS_Human1.18936323
78LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.17710279
79PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.17458506
80CREB1_26743006_Chip-Seq_LNCaP_Human1.17124714
81RXR_22158963_ChIP-Seq_LIVER_Mouse1.17062316
82DNAJC2_21179169_ChIP-ChIP_NT2_Human1.16742406
83TP63_19390658_ChIP-ChIP_HaCaT_Human1.16505824
84KDM2B_26808549_Chip-Seq_DND41_Human1.16185468
85STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.15708294
86* CTCF_26484167_Chip-Seq_Bcells_Mouse1.15616218
87GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.14777066
88SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.14560666
89SPI1_23127762_ChIP-Seq_K562_Human1.14403689
90GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14347285
91PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14283007
92DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.12050250
93* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.09933501
94CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.09015738
95E2F4_17652178_ChIP-ChIP_JURKAT_Human1.08867443
96NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.08783145
97GATA1_19941826_ChIP-Seq_K562_Human1.08134950
98CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07796421
99UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.07640661
100ZFP281_18757296_ChIP-ChIP_E14_Mouse1.07512047
101BCL6_27268052_Chip-Seq_Bcells_Human1.06658503
102GATA1_19941827_ChIP-Seq_MEL_Mouse1.06071602
103* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.05306432
104* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.03928117
105SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03879416
106TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.03153441
107* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02575938
108NCOR1_26117541_ChIP-Seq_K562_Human1.02285379
109CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.02243544
110PHF8_20622854_ChIP-Seq_HELA_Human1.02161245
111SA1_27219007_Chip-Seq_Bcells_Human1.00901313
112CTCF_21964334_Chip-Seq_Bcells_Human1.00843669
113CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.98446277
114PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97766983
115PU.1_20513432_ChIP-Seq_Bcells_Mouse0.95792819
116SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95627675
117HOXB4_20404135_ChIP-ChIP_EML_Mouse0.94015228
118CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93376822
119ERG_20887958_ChIP-Seq_HPC-7_Mouse0.93090698
120SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.92654589
121PU_27001747_Chip-Seq_BMDM_Mouse0.90021625
122LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.89002617
123GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88913507
124MYC_18358816_ChIP-ChIP_MESCs_Mouse0.88190285
125THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.87998803
126FOXP3_21729870_ChIP-Seq_TREG_Human0.87846712
127RARG_19884340_ChIP-ChIP_MEFs_Mouse0.87815701
128STAT3_1855785_ChIP-Seq_MESCs_Mouse0.86687413
129ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85888718
130CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85843084
131* XRN2_22483619_ChIP-Seq_HELA_Human0.85439266
132PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85152786

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.32067644
2MP0000685_abnormal_immune_system3.20171354
3MP0005671_abnormal_response_to2.84816258
4MP0003763_abnormal_thymus_physiology2.68357744
5MP0009785_altered_susceptibility_to2.59581533
6MP0001800_abnormal_humoral_immune2.47352104
7MP0002166_altered_tumor_susceptibility2.39260458
8MP0005387_immune_system_phenotype2.34154633
9MP0001790_abnormal_immune_system2.34154633
10MP0003436_decreased_susceptibility_to2.34090529
11MP0002396_abnormal_hematopoietic_system2.30175961
12MP0003172_abnormal_lysosome_physiology2.29600973
13MP0005025_abnormal_response_to2.14303535
14MP0002452_abnormal_antigen_presenting2.13743377
15MP0005451_abnormal_body_composition2.10742049
16MP0002723_abnormal_immune_serum2.10557788
17MP0008260_abnormal_autophagy2.09399470
18MP0005000_abnormal_immune_tolerance2.08823918
19MP0002420_abnormal_adaptive_immunity2.05436407
20MP0001819_abnormal_immune_cell2.04418072
21MP0001873_stomach_inflammation2.01463664
22MP0002398_abnormal_bone_marrow2.01200231
23MP0002405_respiratory_system_inflammati1.95831316
24MP0004947_skin_inflammation1.89201652
25MP0002006_tumorigenesis1.81849509
26MP0000716_abnormal_immune_system1.81583600
27MP0002419_abnormal_innate_immunity1.80884108
28MP0002138_abnormal_hepatobiliary_system1.80210829
29MP0006082_CNS_inflammation1.78913304
30MP0003693_abnormal_embryo_hatching1.77542077
31MP0009333_abnormal_splenocyte_physiolog1.76767675
32MP0003724_increased_susceptibility_to1.70756692
33MP0002722_abnormal_immune_system1.69761027
34MP0010155_abnormal_intestine_physiology1.68652352
35MP0001853_heart_inflammation1.67926765
36MP0002148_abnormal_hypersensitivity_rea1.67817088
37MP0000689_abnormal_spleen_morphology1.67241065
38MP0009278_abnormal_bone_marrow1.66517485
39MP0005397_hematopoietic_system_phenotyp1.65746549
40MP0001545_abnormal_hematopoietic_system1.65746549
41MP0005464_abnormal_platelet_physiology1.63540141
42MP0010352_gastrointestinal_tract_polyps1.62272120
43MP0002429_abnormal_blood_cell1.61319831
44MP0000703_abnormal_thymus_morphology1.47599898
45MP0003705_abnormal_hypodermis_morpholog1.44771138
46MP0000678_abnormal_parathyroid_gland1.43969830
47MP0000465_gastrointestinal_hemorrhage1.39943962
48MP0003303_peritoneal_inflammation1.39677221
49MP0001845_abnormal_inflammatory_respons1.38733395
50MP0004381_abnormal_hair_follicle1.33235806
51MP0000490_abnormal_crypts_of1.33041982
52MP0000858_altered_metastatic_potential1.33013033
53MP0003191_abnormal_cellular_cholesterol1.31366221
54MP0004808_abnormal_hematopoietic_stem1.30168208
55MP0008469_abnormal_protein_level1.26524866
56MP0002933_joint_inflammation1.23940763
57MP0004510_myositis1.21818571
58MP0008057_abnormal_DNA_replication1.20593638
59MP0009840_abnormal_foam_cell1.20402917
60MP0005023_abnormal_wound_healing1.19994746
61MP0002998_abnormal_bone_remodeling1.16669760
62MP0003077_abnormal_cell_cycle1.16418575
63MP0003300_gastrointestinal_ulcer1.15774526
64MP0003866_abnormal_defecation1.15655518
65MP0005075_abnormal_melanosome_morpholog1.14034302
66MP0004858_abnormal_nervous_system1.10675595
67MP0001851_eye_inflammation1.09311347
68MP0010094_abnormal_chromosome_stability1.07939977
69MP0001533_abnormal_skeleton_physiology1.07860414
70MP0005076_abnormal_cell_differentiation1.06823691
71MP0002019_abnormal_tumor_incidence1.05261388
72MP0003075_altered_response_to1.04288704
73MP0004185_abnormal_adipocyte_glucose1.04242880
74MP0002254_reproductive_system_inflammat1.03339222
75MP0005365_abnormal_bile_salt1.02551725
76MP0003111_abnormal_nucleus_morphology1.02491734
77MP0005310_abnormal_salivary_gland1.02400619
78MP0002249_abnormal_larynx_morphology1.00479179
79MP0003183_abnormal_peptide_metabolism0.96944252
80MP0000609_abnormal_liver_physiology0.96358833
81MP0003011_delayed_dark_adaptation0.95508364
82MP0003448_altered_tumor_morphology0.94218701
83MP0001348_abnormal_lacrimal_gland0.93897877
84MP0005390_skeleton_phenotype0.93543317
85MP0003806_abnormal_nucleotide_metabolis0.93155762
86MP0002132_abnormal_respiratory_system0.92703221
87MP0003315_abnormal_perineum_morphology0.89081027
88MP0002653_abnormal_ependyma_morphology0.89061990
89MP0003453_abnormal_keratinocyte_physiol0.88885806
90MP0005166_decreased_susceptibility_to0.88124284
91MP0009764_decreased_sensitivity_to0.85825951
92MP0003566_abnormal_cell_adhesion0.85818301
93MP0005360_urolithiasis0.85540470
94MP0000681_abnormal_thyroid_gland0.85249426
95MP0002277_abnormal_respiratory_mucosa0.85017385
96MP0003656_abnormal_erythrocyte_physiolo0.84602488
97MP0008007_abnormal_cellular_replicative0.83478287
98MP0003252_abnormal_bile_duct0.82274656
99MP0005670_abnormal_white_adipose0.82156164
100MP0001663_abnormal_digestive_system0.81118274
101MP0008058_abnormal_DNA_repair0.79717174
102MP0000604_amyloidosis0.78615712
103MP0004957_abnormal_blastocyst_morpholog0.77645700
104MP0000313_abnormal_cell_death0.77545212
105MP0002877_abnormal_melanocyte_morpholog0.76833795
106MP0009763_increased_sensitivity_to0.76521115
107MP0000767_abnormal_smooth_muscle0.76335075
108MP0002009_preneoplasia0.76214345
109MP0000343_altered_response_to0.75974431
110MP0003186_abnormal_redox_activity0.75851719
111MP0008961_abnormal_basal_metabolism0.75751159
112MP0005666_abnormal_adipose_tissue0.73665491
113MP0003828_pulmonary_edema0.73376782
114MP0000477_abnormal_intestine_morphology0.72443925
115MP0005375_adipose_tissue_phenotype0.72151751
116MP0008874_decreased_physiological_sensi0.71482548
117MP0000598_abnormal_liver_morphology0.71356376
118MP0003795_abnormal_bone_structure0.67571473
119MP0005058_abnormal_lysosome_morphology0.67541148
120MP0009643_abnormal_urine_homeostasis0.65886274
121MP0009931_abnormal_skin_appearance0.65881979
122MP0008875_abnormal_xenobiotic_pharmacok0.65405601
123MP0002136_abnormal_kidney_physiology0.63631781
124MP0005623_abnormal_meninges_morphology0.62947083
125MP0001764_abnormal_homeostasis0.62313781
126MP0005085_abnormal_gallbladder_physiolo0.62056332
127MP0003879_abnormal_hair_cell0.59858171
128MP0005377_hearing/vestibular/ear_phenot0.59412432
129MP0003878_abnormal_ear_physiology0.59412432
130MP0003329_amyloid_beta_deposits0.58654030
131MP0003091_abnormal_cell_migration0.57672451
132MP0003045_fibrosis0.57443417
133MP0001849_ear_inflammation0.56608667
134MP0008004_abnormal_stomach_pH0.54556779

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)4.48584974
2Recurrent abscess formation (HP:0002722)3.76377513
3Recurrent fungal infections (HP:0002841)3.74255306
4Combined immunodeficiency (HP:0005387)3.61735679
5Severe combined immunodeficiency (HP:0004430)3.53468585
6Eczematoid dermatitis (HP:0000976)3.50186301
7Recurrent viral infections (HP:0004429)3.36000026
8Myositis (HP:0100614)3.25700882
9IgM deficiency (HP:0002850)3.23090539
10Abnormality of the fingertips (HP:0001211)3.22650278
11Abnormality of T cell number (HP:0011839)3.19599509
12T lymphocytopenia (HP:0005403)3.18145604
13Recurrent bacterial skin infections (HP:0005406)3.15616454
14Chronic otitis media (HP:0000389)3.10417628
15Abnormality of T cells (HP:0002843)3.10237294
16Polycythemia (HP:0001901)3.09834899
17Lymphopenia (HP:0001888)3.04447373
18Pustule (HP:0200039)3.04217177
19Recurrent bronchitis (HP:0002837)3.01304137
20Autoimmune thrombocytopenia (HP:0001973)2.99992191
21Abnormality of cells of the lymphoid lineage (HP:0012140)2.96862169
22Nasal polyposis (HP:0100582)2.95221696
23Leukocytosis (HP:0001974)2.91925921
24Chronic mucocutaneous candidiasis (HP:0002728)2.90102465
25Recurrent cutaneous fungal infections (HP:0011370)2.90102465
26Colitis (HP:0002583)2.86427496
27Inflammation of the large intestine (HP:0002037)2.85155854
28Agammaglobulinemia (HP:0004432)2.84633115
29Gastrointestinal inflammation (HP:0004386)2.83093616
30Panhypogammaglobulinemia (HP:0003139)2.82012062
31Abnormality of the nasal mucosa (HP:0000433)2.80357686
32Thyroiditis (HP:0100646)2.76183907
33Abnormal delayed hypersensitivity skin test (HP:0002963)2.75913640
34Recurrent skin infections (HP:0001581)2.69031334
35Orchitis (HP:0100796)2.68754778
36Abnormality of eosinophils (HP:0001879)2.68579139
37Chronic diarrhea (HP:0002028)2.65912357
38Abnormality of T cell physiology (HP:0011840)2.62667840
39Vasculitis (HP:0002633)2.61295013
40Purpura (HP:0000979)2.60687454
41Mediastinal lymphadenopathy (HP:0100721)2.55059452
42Thrombocytosis (HP:0001894)2.55032502
43Petechiae (HP:0000967)2.54161974
44Meningitis (HP:0001287)2.54123952
45Recurrent gram-negative bacterial infections (HP:0005420)2.45793632
46Hypochromic anemia (HP:0001931)2.45436375
47IgG deficiency (HP:0004315)2.43882294
48Cellulitis (HP:0100658)2.41985814
49Hypertensive crisis (HP:0100735)2.40518728
50Recurrent otitis media (HP:0000403)2.38767704
51Periodontitis (HP:0000704)2.38389335
52Granulocytopenia (HP:0001913)2.38276085
53Eosinophilia (HP:0001880)2.37471410
54Fatigue (HP:0012378)2.36067913
55Increased serum ferritin (HP:0003281)2.35139664
56Gingivitis (HP:0000230)2.31593339
57Dysostosis multiplex (HP:0000943)2.30686320
58Epistaxis (HP:0000421)2.30627097
59Stomatitis (HP:0010280)2.28426665
60Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.27169120
61Abnormality of B cell number (HP:0010975)2.26901425
62B lymphocytopenia (HP:0010976)2.26901425
63Interstitial pulmonary disease (HP:0006530)2.25387152
64Recurrent sinusitis (HP:0011108)2.25229648
65Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.21299262
66Abnormality of liposaccharide metabolism (HP:0010968)2.19930230
67Abnormality of glycosphingolipid metabolism (HP:0004343)2.19930230
68Abnormality of glycolipid metabolism (HP:0010969)2.19930230
69Obstructive sleep apnea (HP:0002870)2.19677732
70Increased cerebral lipofuscin (HP:0011813)2.19622252
71Prolonged bleeding time (HP:0003010)2.18828847
72Keratoconjunctivitis sicca (HP:0001097)2.18235567
73Pulmonary infiltrates (HP:0002113)2.17823046
74Ureteral stenosis (HP:0000071)2.15240223
75Slow saccadic eye movements (HP:0000514)2.14357610
76Gingival bleeding (HP:0000225)2.13011870
77Hypercortisolism (HP:0001578)2.12839457
78Hemoptysis (HP:0002105)2.12696372
79Hemorrhage of the eye (HP:0011885)2.12086894
80Loss of speech (HP:0002371)2.11317654
81Lymphoma (HP:0002665)2.09114734
82Cheilitis (HP:0100825)2.08889829
83Increased IgE level (HP:0003212)2.06487948
84Retrobulbar optic neuritis (HP:0100654)2.05791461
85Optic neuritis (HP:0100653)2.05791461
86Breech presentation (HP:0001623)2.04548975
87Spontaneous hematomas (HP:0007420)2.04174182
88Aplastic anemia (HP:0001915)2.02948912
89Osteomyelitis (HP:0002754)2.02022543
90Keratoconjunctivitis (HP:0001096)2.01863353
91Segmental peripheral demyelination/remyelination (HP:0003481)2.00916386
92Emphysema (HP:0002097)2.00239468
93Hypertriglyceridemia (HP:0002155)1.99912088
94Polygenic inheritance (HP:0010982)1.99585099
95Verrucae (HP:0200043)1.99166433
96Papilloma (HP:0012740)1.99166433
97Chest pain (HP:0100749)1.98857203
98IgA deficiency (HP:0002720)1.97875448
99Increased IgM level (HP:0003496)1.97432586
100Abnormal platelet function (HP:0011869)1.97249398
101Impaired platelet aggregation (HP:0003540)1.97249398
102Joint swelling (HP:0001386)1.96750952
103Ureteral obstruction (HP:0006000)1.95550700
104Increased neuronal autofluorescent lipopigment (HP:0002074)1.94552861
105Abnormality of macrophages (HP:0004311)1.93942116
106Skin ulcer (HP:0200042)1.93829145
107Hypoplasia of the thymus (HP:0000778)1.93401487
108Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.92163735
109Gastrointestinal stroma tumor (HP:0100723)1.92154723
110Hepatosplenomegaly (HP:0001433)1.91591600
111Supranuclear gaze palsy (HP:0000605)1.91230150
112Autoimmune hemolytic anemia (HP:0001890)1.90946463
113Episodic fever (HP:0001954)1.90628406
114Pigmentary retinal degeneration (HP:0001146)1.90602722
115Congenital stationary night blindness (HP:0007642)1.89836372
116Gastrointestinal infarctions (HP:0005244)1.89601547
117Pulmonary embolism (HP:0002204)1.87969348
118Amyloidosis (HP:0011034)1.87642279
119Microcytic anemia (HP:0001935)1.86710841
120Arterial thrombosis (HP:0004420)1.86124063
121Abnormality of the prostate (HP:0008775)1.85755952
122Urticaria (HP:0001025)1.85734564
123Hypergammaglobulinemia (HP:0010702)1.85591158
124Abnormality of iron homeostasis (HP:0011031)1.85379207
125Chronic obstructive pulmonary disease (HP:0006510)1.82911991
126Obstructive lung disease (HP:0006536)1.82911991
127Encephalitis (HP:0002383)1.82447923
128Broad face (HP:0000283)1.82342488
129Acne (HP:0001061)1.81459698
130Neuronal loss in central nervous system (HP:0002529)1.80774441
131Systemic lupus erythematosus (HP:0002725)1.80381841
132Abnormality of polysaccharide metabolism (HP:0011012)1.80020197
133Abnormality of glycosaminoglycan metabolism (HP:0004371)1.80020197
134Abnormality of mucopolysaccharide metabolism (HP:0011020)1.80020197
135Restrictive lung disease (HP:0002091)1.79970924
136Hypochromic microcytic anemia (HP:0004840)1.78574108
137Poikiloderma (HP:0001029)1.77532738
138Bronchitis (HP:0012387)1.76848715
139Vacuolated lymphocytes (HP:0001922)1.76770563
140Amaurosis fugax (HP:0100576)1.70932185
141Sepsis (HP:0100806)1.69528671
142Abnormality of the intervertebral disk (HP:0005108)1.69243520

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TBK14.13578611
2MAP4K13.77598774
3PRPF4B3.50123526
4IKBKE3.45448358
5ERN13.37763892
6RIPK43.14522186
7FGFR42.67590196
8TYK22.49182703
9TXK2.44075914
10MAP3K142.19530724
11SMG12.15794668
12STK102.09670392
13JAK32.06384582
14MAP3K102.03350674
15PIM21.94405553
16CDK121.93898162
17RIPK11.93837235
18ZAP701.92504551
19BLK1.90333920
20TNK21.88736969
21IKBKB1.87629926
22GRK61.77731292
23BTK1.74052142
24TAOK31.72843964
25KDR1.72029907
26KIT1.66581222
27ITK1.60792688
28NME21.56199855
29IRAK41.53839031
30JAK11.47619465
31FES1.45101618
32RPS6KA41.42286519
33TGFBR21.36001497
34CHUK1.28302901
35PIM11.23139076
36MARK21.22485208
37TGFBR11.20175004
38PRKD21.19872075
39MARK31.17915349
40TEC1.15055344
41LRRK21.14886812
42MAP3K11.14671324
43TESK21.10745478
44ACVR1B1.10588345
45FGFR31.09712384
46SYK1.08075477
47CDC42BPA1.06949176
48PDPK11.06342780
49CSF1R1.05736775
50EEF2K1.05624382
51EIF2AK11.05496524
52TAOK21.03444504
53SIK31.02287966
54MAP3K111.02096159
55IRAK21.01908320
56MAP2K30.99628987
57EPHB10.99055894
58CSK0.98005919
59KSR20.96735848
60MAP3K130.95702450
61HIPK20.92456662
62LCK0.90441451
63EPHA30.83700895
64NEK20.83202757
65HCK0.83059762
66FLT30.82976456
67MAP3K30.81310595
68TRIB30.79528602
69PDK10.79440856
70CDK40.77570747
71CAMKK10.77200704
72LYN0.76240851
73CDK70.75238283
74TAOK10.74228573
75PKN20.71620727
76SIK10.70665771
77MAPK110.70610060
78ICK0.70019657
79MAPK120.69994502
80MST40.69921839
81STK40.69200517
82MAPK70.68965428
83NLK0.68743444
84FGR0.68028388
85MAPKAPK30.67840141
86RPS6KB20.65225814
87IRAK30.64213558
88BMPR1B0.63115275
89MAP3K80.61533030
90JAK20.58605009
91DYRK30.58581849
92PTK60.57488403
93PRKD30.56838776
94DMPK0.55007634
95TESK10.54743004
96ATR0.54602140
97DYRK1B0.54596820
98ARAF0.54109219
99MAPKAPK20.52910475
100MATK0.52717421
101MOS0.52195795
102GRK10.50884067
103RPS6KA50.50457528
104CLK10.49888503
105MAP3K70.49158433
106BRD40.49115942
107RPS6KA60.48952976
108PRKCQ0.48238171
109RPS6KA20.47969447
110MTOR0.45619073
111SIK20.44814804
112TTN0.44614813
113PAK40.43307852
114BRAF0.41672593
115RPS6KL10.40386329
116RPS6KC10.40386329
117IRAK10.40050425
118STK380.38702218
119RPS6KA10.38332982
120MAP2K20.38099203
121PASK0.37156107
122CDK60.37036280
123MAP3K60.36616567
124STK110.35197268
125FYN0.34698415
126MAP2K60.33601776
127MAPK40.32520155
128MAPK30.32512555
129YES10.31943679
130CDK90.31408132
131BCKDK0.30769753
132PRKCI0.29794548
133CDK80.28221130
134PRKG20.27901370

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.63301986
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.47728034
3Intestinal immune network for IgA production_Homo sapiens_hsa046722.35766405
4Measles_Homo sapiens_hsa051622.30700977
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.23191569
6RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.04246150
7Leishmaniasis_Homo sapiens_hsa051401.98939913
8Antigen processing and presentation_Homo sapiens_hsa046121.96673731
9Base excision repair_Homo sapiens_hsa034101.91955174
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.90548332
11Herpes simplex infection_Homo sapiens_hsa051681.90358064
12Hematopoietic cell lineage_Homo sapiens_hsa046401.81628322
13B cell receptor signaling pathway_Homo sapiens_hsa046621.68315244
14Non-small cell lung cancer_Homo sapiens_hsa052231.60717771
15DNA replication_Homo sapiens_hsa030301.53862811
16Toll-like receptor signaling pathway_Homo sapiens_hsa046201.51633934
17Graft-versus-host disease_Homo sapiens_hsa053321.50921973
18Staphylococcus aureus infection_Homo sapiens_hsa051501.48956095
19Osteoclast differentiation_Homo sapiens_hsa043801.48859919
20T cell receptor signaling pathway_Homo sapiens_hsa046601.48552403
21Influenza A_Homo sapiens_hsa051641.43473960
22Allograft rejection_Homo sapiens_hsa053301.41111456
23Legionellosis_Homo sapiens_hsa051341.40443777
24Jak-STAT signaling pathway_Homo sapiens_hsa046301.38344776
25Caffeine metabolism_Homo sapiens_hsa002321.36307135
26Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.33472009
27Type I diabetes mellitus_Homo sapiens_hsa049401.30338963
28Apoptosis_Homo sapiens_hsa042101.29966709
29Viral myocarditis_Homo sapiens_hsa054161.29305196
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.28617654
31Notch signaling pathway_Homo sapiens_hsa043301.28343294
32Toxoplasmosis_Homo sapiens_hsa051451.24173955
33Other glycan degradation_Homo sapiens_hsa005111.22959879
34p53 signaling pathway_Homo sapiens_hsa041151.21488060
35Acute myeloid leukemia_Homo sapiens_hsa052211.17344525
36Hepatitis B_Homo sapiens_hsa051611.16429985
37Drug metabolism - other enzymes_Homo sapiens_hsa009831.16114150
38Mismatch repair_Homo sapiens_hsa034301.13851279
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.11006923
40NOD-like receptor signaling pathway_Homo sapiens_hsa046211.10786049
41mTOR signaling pathway_Homo sapiens_hsa041501.09422828
42Neurotrophin signaling pathway_Homo sapiens_hsa047221.08494681
43Spliceosome_Homo sapiens_hsa030401.07251087
44TNF signaling pathway_Homo sapiens_hsa046681.06813484
45Shigellosis_Homo sapiens_hsa051311.06209199
46Epstein-Barr virus infection_Homo sapiens_hsa051691.04853525
47Pertussis_Homo sapiens_hsa051331.01122781
48Pentose phosphate pathway_Homo sapiens_hsa000301.01115931
49Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.01105883
50Bladder cancer_Homo sapiens_hsa052191.00997102
51Transcriptional misregulation in cancer_Homo sapiens_hsa052021.00647476
52Leukocyte transendothelial migration_Homo sapiens_hsa046701.00393402
53Sulfur relay system_Homo sapiens_hsa041220.98404323
54Pentose and glucuronate interconversions_Homo sapiens_hsa000400.97227028
55Hepatitis C_Homo sapiens_hsa051600.97129599
56HTLV-I infection_Homo sapiens_hsa051660.95116169
57Malaria_Homo sapiens_hsa051440.91886162
58Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.90996980
59Pancreatic cancer_Homo sapiens_hsa052120.90721359
60Phagosome_Homo sapiens_hsa041450.88612453
61Lysosome_Homo sapiens_hsa041420.85538195
62Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84835903
63Renal cell carcinoma_Homo sapiens_hsa052110.83220502
64Asthma_Homo sapiens_hsa053100.82750798
65Choline metabolism in cancer_Homo sapiens_hsa052310.82391952
66Endocytosis_Homo sapiens_hsa041440.82137324
67Chronic myeloid leukemia_Homo sapiens_hsa052200.81984729
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.81556438
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.80841762
70Prolactin signaling pathway_Homo sapiens_hsa049170.80454093
71ErbB signaling pathway_Homo sapiens_hsa040120.80199063
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79930436
73Rheumatoid arthritis_Homo sapiens_hsa053230.79805276
74Tuberculosis_Homo sapiens_hsa051520.79130893
75African trypanosomiasis_Homo sapiens_hsa051430.77889157
76Non-homologous end-joining_Homo sapiens_hsa034500.77798949
77Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.76689092
78Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.76563394
79Prion diseases_Homo sapiens_hsa050200.76280420
80Inositol phosphate metabolism_Homo sapiens_hsa005620.76141482
81One carbon pool by folate_Homo sapiens_hsa006700.75376244
82Viral carcinogenesis_Homo sapiens_hsa052030.74348702
83Endometrial cancer_Homo sapiens_hsa052130.74208297
84Chemokine signaling pathway_Homo sapiens_hsa040620.73632378
85Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.73303279
86Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72909737
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.72765892
88Cell cycle_Homo sapiens_hsa041100.72016359
89ABC transporters_Homo sapiens_hsa020100.71831100
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71274019
91Small cell lung cancer_Homo sapiens_hsa052220.70829489
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70731966
93Autoimmune thyroid disease_Homo sapiens_hsa053200.69823556
94Lysine degradation_Homo sapiens_hsa003100.69457716
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68999608
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68500831
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67829498
98Selenocompound metabolism_Homo sapiens_hsa004500.66820789
99Complement and coagulation cascades_Homo sapiens_hsa046100.65456596
100Insulin signaling pathway_Homo sapiens_hsa049100.65257153
101Proteasome_Homo sapiens_hsa030500.64495788
102Homologous recombination_Homo sapiens_hsa034400.64476615
103Glioma_Homo sapiens_hsa052140.63797495
104HIF-1 signaling pathway_Homo sapiens_hsa040660.62996154
105Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60880254
106Tryptophan metabolism_Homo sapiens_hsa003800.60669102
107GnRH signaling pathway_Homo sapiens_hsa049120.60575463
108Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.60181402
109Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59506535
110Ribosome_Homo sapiens_hsa030100.58705469
111Colorectal cancer_Homo sapiens_hsa052100.58353818
112SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57574796
113Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55449053
114RNA transport_Homo sapiens_hsa030130.53394316
115MAPK signaling pathway_Homo sapiens_hsa040100.52282989
116Central carbon metabolism in cancer_Homo sapiens_hsa052300.52014742
117FoxO signaling pathway_Homo sapiens_hsa040680.51030622
118Glycosaminoglycan degradation_Homo sapiens_hsa005310.50845167
119Fructose and mannose metabolism_Homo sapiens_hsa000510.50436065
120Amoebiasis_Homo sapiens_hsa051460.50388921
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49599101
122Folate biosynthesis_Homo sapiens_hsa007900.49102864
123AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48423051
124Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47794735
125Salmonella infection_Homo sapiens_hsa051320.47405820
126Pyrimidine metabolism_Homo sapiens_hsa002400.46950059
127Prostate cancer_Homo sapiens_hsa052150.46940794
128Steroid hormone biosynthesis_Homo sapiens_hsa001400.46863385
129Phototransduction_Homo sapiens_hsa047440.46470090
130RNA degradation_Homo sapiens_hsa030180.44432839
131Galactose metabolism_Homo sapiens_hsa000520.44140932
132Chemical carcinogenesis_Homo sapiens_hsa052040.41448599
133Fanconi anemia pathway_Homo sapiens_hsa034600.41050959
134Primary bile acid biosynthesis_Homo sapiens_hsa001200.39449583
135Insulin resistance_Homo sapiens_hsa049310.39012118
136Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38028055
137Fatty acid degradation_Homo sapiens_hsa000710.37491452
138VEGF signaling pathway_Homo sapiens_hsa043700.37417792
139Starch and sucrose metabolism_Homo sapiens_hsa005000.36307411
140Platelet activation_Homo sapiens_hsa046110.35945462

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