

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | nuclear pore complex assembly (GO:0051292) | 6.09847721 |
| 2 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 5.73273052 |
| 3 | nuclear pore organization (GO:0006999) | 5.45087310 |
| 4 | mitotic sister chromatid cohesion (GO:0007064) | 4.94596075 |
| 5 | pore complex assembly (GO:0046931) | 4.76631325 |
| 6 | regulation of RNA export from nucleus (GO:0046831) | 4.12287527 |
| 7 | monoubiquitinated protein deubiquitination (GO:0035520) | 4.05013680 |
| 8 | histone H3-K4 trimethylation (GO:0080182) | 3.98275492 |
| 9 | negative regulation of histone methylation (GO:0031061) | 3.91680312 |
| 10 | histone H3-K9 demethylation (GO:0033169) | 3.77889255 |
| 11 | histone H3-K4 methylation (GO:0051568) | 3.74815029 |
| 12 | regulation of gene silencing by RNA (GO:0060966) | 3.70963209 |
| 13 | regulation of posttranscriptional gene silencing (GO:0060147) | 3.70963209 |
| 14 | regulation of gene silencing by miRNA (GO:0060964) | 3.70963209 |
| 15 | mitotic chromosome condensation (GO:0007076) | 3.68736840 |
| 16 | regulation of histone H3-K9 methylation (GO:0051570) | 3.59883654 |
| 17 | regulation of chromatin silencing (GO:0031935) | 3.57665130 |
| 18 | peptidyl-lysine trimethylation (GO:0018023) | 3.55921234 |
| 19 | DNA unwinding involved in DNA replication (GO:0006268) | 3.55571213 |
| 20 | regulation of sister chromatid cohesion (GO:0007063) | 3.49039800 |
| 21 | pre-miRNA processing (GO:0031054) | 3.45002143 |
| 22 | intra-S DNA damage checkpoint (GO:0031573) | 3.40943864 |
| 23 | regulation of nucleobase-containing compound transport (GO:0032239) | 3.35624045 |
| 24 | regulation of DNA methylation (GO:0044030) | 3.35121618 |
| 25 | mitotic nuclear envelope disassembly (GO:0007077) | 3.33014888 |
| 26 | sister chromatid cohesion (GO:0007062) | 3.31697379 |
| 27 | cytoplasmic mRNA processing body assembly (GO:0033962) | 3.31680737 |
| 28 | negative regulation of translation involved in gene silencing by miRNA (GO:0035278) | 3.30514834 |
| 29 | negative regulation of translation, ncRNA-mediated (GO:0040033) | 3.30514834 |
| 30 | regulation of translation, ncRNA-mediated (GO:0045974) | 3.30514834 |
| 31 | regulation of gene silencing (GO:0060968) | 3.29002286 |
| 32 | positive regulation of mitotic metaphase/anaphase transition (GO:0045842) | 3.28113110 |
| 33 | positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101) | 3.28113110 |
| 34 | positive regulation of mitotic sister chromatid separation (GO:1901970) | 3.28113110 |
| 35 | positive regulation of histone methylation (GO:0031062) | 3.27683596 |
| 36 | regulation of DNA endoreduplication (GO:0032875) | 3.26626331 |
| 37 | meiotic chromosome segregation (GO:0045132) | 3.25525071 |
| 38 | negative regulation of fibroblast apoptotic process (GO:2000270) | 3.22461482 |
| 39 | histone H4-K12 acetylation (GO:0043983) | 3.18651956 |
| 40 | nuclear envelope disassembly (GO:0051081) | 3.18079351 |
| 41 | membrane disassembly (GO:0030397) | 3.18079351 |
| 42 | histone lysine methylation (GO:0034968) | 3.17889530 |
| 43 | DNA duplex unwinding (GO:0032508) | 3.16522734 |
| 44 | positive regulation of histone H3-K4 methylation (GO:0051571) | 3.15142615 |
| 45 | protein localization to kinetochore (GO:0034501) | 3.14936814 |
| 46 | DNA geometric change (GO:0032392) | 3.14899874 |
| 47 | protein dealkylation (GO:0008214) | 3.14434585 |
| 48 | protein demethylation (GO:0006482) | 3.14434585 |
| 49 | regulation of histone methylation (GO:0031060) | 3.11342426 |
| 50 | regulation of helicase activity (GO:0051095) | 3.11182364 |
| 51 | nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289) | 3.09892905 |
| 52 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 3.06958574 |
| 53 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 3.06958574 |
| 54 | peptidyl-lysine methylation (GO:0018022) | 3.06434454 |
| 55 | histone mRNA catabolic process (GO:0071044) | 3.03442390 |
| 56 | dosage compensation (GO:0007549) | 3.02545137 |
| 57 | regulation of chromatin binding (GO:0035561) | 3.02478936 |
| 58 | non-recombinational repair (GO:0000726) | 3.02093884 |
| 59 | double-strand break repair via nonhomologous end joining (GO:0006303) | 3.02093884 |
| 60 | protein localization to chromosome, centromeric region (GO:0071459) | 3.01741538 |
| 61 | sister chromatid segregation (GO:0000819) | 3.00919447 |
| 62 | regulation of telomere maintenance via telomerase (GO:0032210) | 2.99590813 |
| 63 | histone H4-K16 acetylation (GO:0043984) | 2.97428253 |
| 64 | positive regulation of transcription from RNA polymerase III promoter (GO:0045945) | 2.97053667 |
| 65 | regulation of mitotic spindle organization (GO:0060236) | 2.97024680 |
| 66 | interkinetic nuclear migration (GO:0022027) | 2.94355119 |
| 67 | N-terminal protein amino acid acetylation (GO:0006474) | 2.93331346 |
| 68 | negative regulation of DNA repair (GO:0045738) | 2.92108822 |
| 69 | determination of adult lifespan (GO:0008340) | 2.91921571 |
| 70 | gene silencing by RNA (GO:0031047) | 2.90689482 |
| 71 | chromatin assembly (GO:0031497) | 2.89377609 |
| 72 | histone H4-K5 acetylation (GO:0043981) | 2.89144081 |
| 73 | histone H4-K8 acetylation (GO:0043982) | 2.89144081 |
| 74 | centrosome localization (GO:0051642) | 2.89136955 |
| 75 | histone H4 acetylation (GO:0043967) | 2.88471916 |
| 76 | paraxial mesoderm development (GO:0048339) | 2.88398614 |
| 77 | regulation of spindle organization (GO:0090224) | 2.87195199 |
| 78 | snRNA processing (GO:0016180) | 2.84728428 |
| 79 | establishment of nucleus localization (GO:0040023) | 2.84598655 |
| 80 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 2.83708302 |
| 81 | heterochromatin organization (GO:0070828) | 2.83603107 |
| 82 | histone H3-K9 methylation (GO:0051567) | 2.83547884 |
| 83 | gene silencing (GO:0016458) | 2.83148867 |
| 84 | histone H3-K36 demethylation (GO:0070544) | 2.82317395 |
| 85 | erythrocyte maturation (GO:0043249) | 2.81866918 |
| 86 | chromatin assembly or disassembly (GO:0006333) | 2.81392439 |
| 87 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 2.79358146 |
| 88 | snRNA metabolic process (GO:0016073) | 2.79073694 |
| 89 | kinetochore organization (GO:0051383) | 2.77801069 |
| 90 | attachment of spindle microtubules to kinetochore (GO:0008608) | 2.76657561 |
| 91 | chromatin silencing (GO:0006342) | 2.75719846 |
| 92 | DNA strand renaturation (GO:0000733) | 2.75025732 |
| 93 | oocyte development (GO:0048599) | 2.74912518 |
| 94 | positive regulation of gamma-delta T cell activation (GO:0046645) | 2.73906698 |
| 95 | regulation of centriole replication (GO:0046599) | 2.73246576 |
| 96 | nuclear envelope organization (GO:0006998) | 2.72661028 |
| 97 | DNA conformation change (GO:0071103) | 2.71996288 |
| 98 | DNA replication-independent nucleosome assembly (GO:0006336) | 2.71582684 |
| 99 | DNA replication-independent nucleosome organization (GO:0034724) | 2.71582684 |
| 100 | response to UV-C (GO:0010225) | 2.71517914 |
| 101 | regulation of telomere maintenance (GO:0032204) | 2.70832786 |
| 102 | regulation of protein polyubiquitination (GO:1902914) | 2.70587512 |
| 103 | histone demethylation (GO:0016577) | 2.70537376 |
| 104 | NLS-bearing protein import into nucleus (GO:0006607) | 2.70241550 |
| 105 | regulation of DNA damage checkpoint (GO:2000001) | 2.69349726 |
| 106 | positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145) | 2.69230433 |
| 107 | positive regulation of gene expression, epigenetic (GO:0045815) | 2.69030631 |
| 108 | negative regulation of chromatin modification (GO:1903309) | 2.68948904 |
| 109 | DNA synthesis involved in DNA repair (GO:0000731) | 2.68900576 |
| 110 | histone phosphorylation (GO:0016572) | 2.67138597 |
| 111 | mitotic sister chromatid segregation (GO:0000070) | 2.66976056 |
| 112 | DNA replication-dependent nucleosome assembly (GO:0006335) | 2.66896631 |
| 113 | DNA replication-dependent nucleosome organization (GO:0034723) | 2.66896631 |
| 114 | histone lysine demethylation (GO:0070076) | 2.66444635 |
| 115 | glucocorticoid receptor signaling pathway (GO:0042921) | 2.66282615 |
| 116 | DNA demethylation (GO:0080111) | 2.66233933 |
| 117 | V(D)J recombination (GO:0033151) | 2.66034062 |
| 118 | negative regulation of histone modification (GO:0031057) | 2.65840897 |
| 119 | regulation of centrosome duplication (GO:0010824) | 2.65579094 |
| 120 | negative regulation of DNA recombination (GO:0045910) | 2.65389924 |
| 121 | rRNA catabolic process (GO:0016075) | 2.65143598 |
| 122 | positive regulation of chromosome segregation (GO:0051984) | 2.64501076 |
| 123 | mitotic G2/M transition checkpoint (GO:0044818) | 2.64307540 |
| 124 | phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092) | 2.64244306 |
| 125 | regulation of histone H3-K27 methylation (GO:0061085) | 2.64161152 |
| 126 | peptidyl-lysine dimethylation (GO:0018027) | 2.63500504 |
| 127 | regulation of histone H3-K4 methylation (GO:0051569) | 2.63363920 |
| 128 | positive regulation of developmental pigmentation (GO:0048087) | 2.62251136 |
| 129 | RNA stabilization (GO:0043489) | 2.59863251 |
| 130 | mRNA stabilization (GO:0048255) | 2.59863251 |
| 131 | genitalia morphogenesis (GO:0035112) | 2.59524280 |
| 132 | ATP-dependent chromatin remodeling (GO:0043044) | 2.58147652 |
| 133 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 2.57547243 |
| 134 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 2.56368596 |
| 135 | negative regulation of gene expression, epigenetic (GO:0045814) | 2.56331885 |
| 136 | regulation of centrosome cycle (GO:0046605) | 2.55348167 |
| 137 | mRNA transport (GO:0051028) | 2.53490527 |
| 138 | nucleus organization (GO:0006997) | 2.53345766 |
| 139 | peptidyl-threonine phosphorylation (GO:0018107) | 2.52961822 |
| 140 | protein K48-linked deubiquitination (GO:0071108) | 2.52745946 |
| 141 | positive regulation of SMAD protein import into nucleus (GO:0060391) | 2.50623054 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 9.48881511 |
| 2 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 4.13266971 |
| 3 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 3.52271759 |
| 4 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 3.49916339 |
| 5 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.43546182 |
| 6 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 3.37133675 |
| 7 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 3.36406630 |
| 8 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 2.97882668 |
| 9 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 2.56638288 |
| 10 | MYC_22102868_ChIP-Seq_BL_Human | 2.48670548 |
| 11 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 2.44169618 |
| 12 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.38066011 |
| 13 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 2.31716243 |
| 14 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 2.24881320 |
| 15 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 2.11254510 |
| 16 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 2.02034154 |
| 17 | GATA1_22025678_ChIP-Seq_K562_Human | 2.01862285 |
| 18 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.97517205 |
| 19 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.94195232 |
| 20 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.86453912 |
| 21 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.85088200 |
| 22 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.76509707 |
| 23 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 1.71089593 |
| 24 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 1.69143016 |
| 25 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.67907636 |
| 26 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.67281988 |
| 27 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.66488749 |
| 28 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.64095426 |
| 29 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.59426598 |
| 30 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.56749039 |
| 31 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.55433741 |
| 32 | PKCTHETA_26484144_Chip-Seq_BREAST_Human | 1.49200222 |
| 33 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 1.47452932 |
| 34 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.45841209 |
| 35 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.44490790 |
| 36 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.43867838 |
| 37 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.43867838 |
| 38 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.43867838 |
| 39 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.43518991 |
| 40 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.38266929 |
| 41 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.36723597 |
| 42 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.36713676 |
| 43 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.36696433 |
| 44 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.34903406 |
| 45 | DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 1.34262091 |
| 46 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 1.31713375 |
| 47 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.27927801 |
| 48 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.27668244 |
| 49 | MYB_26560356_Chip-Seq_TH2_Human | 1.26570522 |
| 50 | MYB_26560356_Chip-Seq_TH1_Human | 1.25421456 |
| 51 | * FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.24949275 |
| 52 | FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human | 1.24211990 |
| 53 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.21723274 |
| 54 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.21451464 |
| 55 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.20395312 |
| 56 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.19836930 |
| 57 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.19121769 |
| 58 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.17974859 |
| 59 | ISL1_27105846_Chip-Seq_CPCs_Mouse | 1.17657591 |
| 60 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.17182506 |
| 61 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 1.17021807 |
| 62 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 1.16328379 |
| 63 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.15535528 |
| 64 | EWS_26573619_Chip-Seq_HEK293_Human | 1.15298573 |
| 65 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 1.14978180 |
| 66 | P300_19829295_ChIP-Seq_ESCs_Human | 1.14725114 |
| 67 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.14308211 |
| 68 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.14164861 |
| 69 | TBX3_20139965_ChIP-Seq_ESCs_Mouse | 1.12623897 |
| 70 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.12374245 |
| 71 | TBX3_20139965_ChIP-Seq_MESCs_Mouse | 1.11756408 |
| 72 | FOXM1_26456572_ChIP-Seq_MCF-7_Human | 1.10356986 |
| 73 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.09559033 |
| 74 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 1.09535068 |
| 75 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.08072068 |
| 76 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.07245051 |
| 77 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.07094344 |
| 78 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 1.06912001 |
| 79 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.05372758 |
| 80 | RUNX_20019798_ChIP-Seq_JUKART_Human | 1.03906254 |
| 81 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.02928055 |
| 82 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.02923291 |
| 83 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 1.02515855 |
| 84 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 1.01268561 |
| 85 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.01227646 |
| 86 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.00621578 |
| 87 | TCF4_18268006_ChIP-ChIP_LS174T_Human | 1.00200449 |
| 88 | STAT3_23295773_ChIP-Seq_U87_Human | 0.99473192 |
| 89 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 0.99081924 |
| 90 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 0.98289904 |
| 91 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 0.98270858 |
| 92 | AHR_22903824_ChIP-Seq_MCF-7_Human | 0.98127516 |
| 93 | VDR_23849224_ChIP-Seq_CD4+_Human | 0.98065487 |
| 94 | TCF3_18692474_ChIP-Seq_MESCs_Mouse | 0.97910820 |
| 95 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 0.97728057 |
| 96 | STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse | 0.97372615 |
| 97 | TCF4_23295773_ChIP-Seq_U87_Human | 0.97223694 |
| 98 | FOXP3_21729870_ChIP-Seq_TREG_Human | 0.96257481 |
| 99 | FUS_26573619_Chip-Seq_HEK293_Human | 0.96009570 |
| 100 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.95693782 |
| 101 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 0.95489804 |
| 102 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.95459217 |
| 103 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.95242345 |
| 104 | GF1B_26923725_Chip-Seq_HPCs_Mouse | 0.95068061 |
| 105 | SALL4_18804426_ChIP-ChIP_XEN_Mouse | 0.94206203 |
| 106 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.93619000 |
| 107 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 0.93467852 |
| 108 | TP53_16413492_ChIP-PET_HCT116_Human | 0.93030388 |
| 109 | FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.92862176 |
| 110 | SPI1_23127762_ChIP-Seq_K562_Human | 0.92056813 |
| 111 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.91187534 |
| 112 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 0.91075889 |
| 113 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.90583641 |
| 114 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.89912842 |
| 115 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 0.89581275 |
| 116 | POU5F1_18347094_ChIP-ChIP_MESCs_Mouse | 0.88747011 |
| 117 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 0.88682711 |
| 118 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 0.87772712 |
| 119 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 0.87622602 |
| 120 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 0.87605995 |
| 121 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.86829414 |
| 122 | BRD4_25478319_ChIP-Seq_HGPS_Human | 0.86578329 |
| 123 | E2F1_18555785_Chip-Seq_ESCs_Mouse | 0.86163251 |
| 124 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 0.84666359 |
| 125 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 0.84304335 |
| 126 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 0.80458363 |
| 127 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 0.79405358 |
| 128 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 0.77775693 |
| 129 | CHD1_26751641_Chip-Seq_LNCaP_Human | 0.76460069 |
| 130 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 0.75966587 |
| 131 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 0.75568452 |
| 132 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 0.74481335 |
| 133 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 0.73615266 |
| 134 | GATA3_27048872_Chip-Seq_THYMUS_Human | 0.72432206 |
| 135 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 0.72214568 |
| 136 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.72214568 |
| 137 | UTX_26944678_Chip-Seq_JUKART_Human | 0.71054686 |
| 138 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 0.69990513 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0000569_abnormal_digit_pigmentation | 4.62858459 |
| 2 | MP0010094_abnormal_chromosome_stability | 3.57822239 |
| 3 | MP0003787_abnormal_imprinting | 3.35920076 |
| 4 | MP0008057_abnormal_DNA_replication | 3.24428089 |
| 5 | MP0008877_abnormal_DNA_methylation | 3.05667391 |
| 6 | MP0002009_preneoplasia | 3.04055271 |
| 7 | MP0002396_abnormal_hematopoietic_system | 3.00411655 |
| 8 | MP0003111_abnormal_nucleus_morphology | 2.90087213 |
| 9 | MP0003121_genomic_imprinting | 2.88154276 |
| 10 | MP0010307_abnormal_tumor_latency | 2.68640321 |
| 11 | MP0003077_abnormal_cell_cycle | 2.56096406 |
| 12 | MP0003693_abnormal_embryo_hatching | 2.44316112 |
| 13 | MP0010352_gastrointestinal_tract_polyps | 2.41199257 |
| 14 | MP0008058_abnormal_DNA_repair | 2.40160340 |
| 15 | MP0002877_abnormal_melanocyte_morpholog | 2.36948618 |
| 16 | MP0004808_abnormal_hematopoietic_stem | 2.35974280 |
| 17 | MP0005076_abnormal_cell_differentiation | 2.29085186 |
| 18 | MP0004264_abnormal_extraembryonic_tissu | 2.05895935 |
| 19 | MP0003890_abnormal_embryonic-extraembry | 2.04916671 |
| 20 | MP0001293_anophthalmia | 1.93410119 |
| 21 | MP0003183_abnormal_peptide_metabolism | 1.93147727 |
| 22 | MP0003300_gastrointestinal_ulcer | 1.82529522 |
| 23 | MP0008007_abnormal_cellular_replicative | 1.75938343 |
| 24 | MP0000371_diluted_coat_color | 1.68866836 |
| 25 | MP0004957_abnormal_blastocyst_morpholog | 1.65392489 |
| 26 | MP0005310_abnormal_salivary_gland | 1.62921379 |
| 27 | MP0003123_paternal_imprinting | 1.62893796 |
| 28 | MP0000350_abnormal_cell_proliferation | 1.59935272 |
| 29 | MP0000428_abnormal_craniofacial_morphol | 1.58285285 |
| 30 | MP0000537_abnormal_urethra_morphology | 1.57871611 |
| 31 | MP0005075_abnormal_melanosome_morpholog | 1.56556688 |
| 32 | MP0003937_abnormal_limbs/digits/tail_de | 1.56158393 |
| 33 | MP0003941_abnormal_skin_development | 1.55798206 |
| 34 | MP0009697_abnormal_copulation | 1.54545699 |
| 35 | MP0003763_abnormal_thymus_physiology | 1.50707560 |
| 36 | MP0001730_embryonic_growth_arrest | 1.46060478 |
| 37 | MP0009703_decreased_birth_body | 1.44796821 |
| 38 | MP0005174_abnormal_tail_pigmentation | 1.44418362 |
| 39 | MP0010678_abnormal_skin_adnexa | 1.43156770 |
| 40 | MP0002166_altered_tumor_susceptibility | 1.41554143 |
| 41 | MP0003122_maternal_imprinting | 1.41342831 |
| 42 | MP0005380_embryogenesis_phenotype | 1.39285534 |
| 43 | MP0001672_abnormal_embryogenesis/_devel | 1.39285534 |
| 44 | MP0002084_abnormal_developmental_patter | 1.38941326 |
| 45 | MP0005409_darkened_coat_color | 1.38699436 |
| 46 | MP0002398_abnormal_bone_marrow | 1.38501797 |
| 47 | MP0003984_embryonic_growth_retardation | 1.37871379 |
| 48 | MP0005248_abnormal_Harderian_gland | 1.36372788 |
| 49 | MP0000703_abnormal_thymus_morphology | 1.35234545 |
| 50 | MP0000383_abnormal_hair_follicle | 1.34987832 |
| 51 | MP0002086_abnormal_extraembryonic_tissu | 1.34230677 |
| 52 | MP0002088_abnormal_embryonic_growth/wei | 1.32372098 |
| 53 | MP0001286_abnormal_eye_development | 1.29433542 |
| 54 | MP0002697_abnormal_eye_size | 1.29266006 |
| 55 | MP0002006_tumorigenesis | 1.26855220 |
| 56 | MP0000313_abnormal_cell_death | 1.22112116 |
| 57 | MP0001697_abnormal_embryo_size | 1.21939999 |
| 58 | MP0002254_reproductive_system_inflammat | 1.20199706 |
| 59 | MP0005187_abnormal_penis_morphology | 1.19631269 |
| 60 | MP0002075_abnormal_coat/hair_pigmentati | 1.15651012 |
| 61 | MP0002085_abnormal_embryonic_tissue | 1.13952820 |
| 62 | MP0004197_abnormal_fetal_growth/weight/ | 1.12823941 |
| 63 | MP0009672_abnormal_birth_weight | 1.12774676 |
| 64 | MP0002095_abnormal_skin_pigmentation | 1.12325709 |
| 65 | MP0000015_abnormal_ear_pigmentation | 1.10870884 |
| 66 | MP0003221_abnormal_cardiomyocyte_apopto | 1.10331047 |
| 67 | MP0003943_abnormal_hepatobiliary_system | 1.07637988 |
| 68 | MP0002092_abnormal_eye_morphology | 1.05578257 |
| 69 | MP0005671_abnormal_response_to | 1.05061452 |
| 70 | MP0005621_abnormal_cell_physiology | 1.04566388 |
| 71 | MP0003136_yellow_coat_color | 1.04487829 |
| 72 | MP0001545_abnormal_hematopoietic_system | 1.03314173 |
| 73 | MP0005397_hematopoietic_system_phenotyp | 1.03314173 |
| 74 | MP0002080_prenatal_lethality | 1.02015687 |
| 75 | MP0003119_abnormal_digestive_system | 1.00211600 |
| 76 | MP0001800_abnormal_humoral_immune | 0.99617024 |
| 77 | MP0005384_cellular_phenotype | 0.96973452 |
| 78 | MP0008961_abnormal_basal_metabolism | 0.96420590 |
| 79 | MP0004185_abnormal_adipocyte_glucose | 0.95679672 |
| 80 | MP0003172_abnormal_lysosome_physiology | 0.92798997 |
| 81 | MP0003567_abnormal_fetal_cardiomyocyte | 0.92736962 |
| 82 | MP0002233_abnormal_nose_morphology | 0.91706988 |
| 83 | MP0002019_abnormal_tumor_incidence | 0.91407321 |
| 84 | MP0000490_abnormal_crypts_of | 0.91275188 |
| 85 | MP0000377_abnormal_hair_follicle | 0.90427725 |
| 86 | MP0003045_fibrosis | 0.90369587 |
| 87 | MP0006292_abnormal_olfactory_placode | 0.90244653 |
| 88 | MP0000647_abnormal_sebaceous_gland | 0.89885685 |
| 89 | MP0000716_abnormal_immune_system | 0.89686386 |
| 90 | MP0001873_stomach_inflammation | 0.89683640 |
| 91 | MP0004381_abnormal_hair_follicle | 0.89630699 |
| 92 | MP0005367_renal/urinary_system_phenotyp | 0.89324912 |
| 93 | MP0000516_abnormal_urinary_system | 0.89324912 |
| 94 | MP0001929_abnormal_gametogenesis | 0.89281709 |
| 95 | MP0001186_pigmentation_phenotype | 0.88533894 |
| 96 | MP0000689_abnormal_spleen_morphology | 0.88386983 |
| 97 | MP0002928_abnormal_bile_duct | 0.88349114 |
| 98 | MP0002722_abnormal_immune_system | 0.88338070 |
| 99 | MP0002111_abnormal_tail_morphology | 0.87190577 |
| 100 | MP0002210_abnormal_sex_determination | 0.85167106 |
| 101 | MP0005646_abnormal_pituitary_gland | 0.84807494 |
| 102 | MP0005499_abnormal_olfactory_system | 0.84717427 |
| 103 | MP0005394_taste/olfaction_phenotype | 0.84717427 |
| 104 | MP0002429_abnormal_blood_cell | 0.84224418 |
| 105 | MP0000653_abnormal_sex_gland | 0.84136633 |
| 106 | MP0003718_maternal_effect | 0.83408752 |
| 107 | MP0000427_abnormal_hair_cycle | 0.83306685 |
| 108 | MP0001145_abnormal_male_reproductive | 0.82561162 |
| 109 | MP0003115_abnormal_respiratory_system | 0.81346588 |
| 110 | MP0001119_abnormal_female_reproductive | 0.80806272 |
| 111 | MP0010234_abnormal_vibrissa_follicle | 0.80441022 |
| 112 | MP0002160_abnormal_reproductive_system | 0.79697670 |
| 113 | MP0009780_abnormal_chondrocyte_physiolo | 0.79685918 |
| 114 | MP0002420_abnormal_adaptive_immunity | 0.78198116 |
| 115 | MP0001915_intracranial_hemorrhage | 0.77511962 |
| 116 | MP0000631_abnormal_neuroendocrine_gland | 0.77310906 |
| 117 | MP0002452_abnormal_antigen_presenting | 0.77014688 |
| 118 | MP0001819_abnormal_immune_cell | 0.75564862 |
| 119 | MP0001188_hyperpigmentation | 0.74306529 |
| 120 | MP0002938_white_spotting | 0.73712365 |
| 121 | MP0002081_perinatal_lethality | 0.73152575 |
| 122 | MP0003935_abnormal_craniofacial_develop | 0.71906421 |
| 123 | MP0008932_abnormal_embryonic_tissue | 0.70146584 |
| 124 | MP0000778_abnormal_nervous_system | 0.69560283 |
| 125 | MP0002925_abnormal_cardiovascular_devel | 0.69208283 |
| 126 | MP0003705_abnormal_hypodermis_morpholog | 0.68839966 |
| 127 | MP0000432_abnormal_head_morphology | 0.68495948 |
| 128 | MP0003861_abnormal_nervous_system | 0.68477659 |
| 129 | MP0000003_abnormal_adipose_tissue | 0.67603942 |
| 130 | MP0003091_abnormal_cell_migration | 0.67428061 |
| 131 | MP0002751_abnormal_autonomic_nervous | 0.66697072 |
| 132 | MP0005389_reproductive_system_phenotype | 0.66443686 |
| 133 | MP0008260_abnormal_autophagy | 0.64564640 |
| 134 | MP0003938_abnormal_ear_development | 0.64042930 |
| 135 | MP0001299_abnormal_eye_distance/ | 0.61695005 |
| 136 | MP0005220_abnormal_exocrine_pancreas | 0.59250310 |
| 137 | MP0008770_decreased_survivor_rate | 0.59235035 |
| 138 | MP0003699_abnormal_female_reproductive | 0.58468011 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Volvulus (HP:0002580) | 4.62752388 |
| 2 | Abnormality of the fingertips (HP:0001211) | 4.37388825 |
| 3 | Hepatoblastoma (HP:0002884) | 3.83508750 |
| 4 | Ependymoma (HP:0002888) | 3.74847652 |
| 5 | Abnormality of the astrocytes (HP:0100707) | 3.43475022 |
| 6 | Astrocytoma (HP:0009592) | 3.43475022 |
| 7 | Syringomyelia (HP:0003396) | 3.37271130 |
| 8 | Spinal cord lesions (HP:0100561) | 3.37271130 |
| 9 | Papillary thyroid carcinoma (HP:0002895) | 3.01154120 |
| 10 | Embryonal renal neoplasm (HP:0011794) | 3.00179630 |
| 11 | Chromsome breakage (HP:0040012) | 2.97330842 |
| 12 | Medulloblastoma (HP:0002885) | 2.95522008 |
| 13 | Glioma (HP:0009733) | 2.93909453 |
| 14 | Long eyelashes (HP:0000527) | 2.87583087 |
| 15 | Macroorchidism (HP:0000053) | 2.84418137 |
| 16 | Urethral obstruction (HP:0000796) | 2.73230156 |
| 17 | Aqueductal stenosis (HP:0002410) | 2.67450409 |
| 18 | Agnosia (HP:0010524) | 2.67400349 |
| 19 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.65877820 |
| 20 | Prominent nose (HP:0000448) | 2.59980393 |
| 21 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 2.59858164 |
| 22 | Short 4th metacarpal (HP:0010044) | 2.59858164 |
| 23 | Genetic anticipation (HP:0003743) | 2.54584754 |
| 24 | Absent frontal sinuses (HP:0002688) | 2.46547102 |
| 25 | Truncal obesity (HP:0001956) | 2.46416242 |
| 26 | Acute myeloid leukemia (HP:0004808) | 2.43784670 |
| 27 | Ectopic kidney (HP:0000086) | 2.42667790 |
| 28 | Neonatal hypoglycemia (HP:0001998) | 2.41800252 |
| 29 | Neoplasm of the oral cavity (HP:0100649) | 2.40686088 |
| 30 | Narrow palate (HP:0000189) | 2.38898650 |
| 31 | Abnormal pancreas size (HP:0012094) | 2.36871866 |
| 32 | Diastasis recti (HP:0001540) | 2.34851333 |
| 33 | Curly hair (HP:0002212) | 2.32409634 |
| 34 | Subacute progressive viral hepatitis (HP:0006572) | 2.31337649 |
| 35 | Hypochromic microcytic anemia (HP:0004840) | 2.30462598 |
| 36 | Abnormality of chromosome stability (HP:0003220) | 2.29497834 |
| 37 | Rhabdomyosarcoma (HP:0002859) | 2.26451263 |
| 38 | High anterior hairline (HP:0009890) | 2.23083608 |
| 39 | Lip pit (HP:0100267) | 2.21170700 |
| 40 | Cystic hygroma (HP:0000476) | 2.18614243 |
| 41 | Trigonocephaly (HP:0000243) | 2.14727553 |
| 42 | Neoplasm of striated muscle (HP:0009728) | 2.14097293 |
| 43 | Myelodysplasia (HP:0002863) | 2.13088039 |
| 44 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 2.10331160 |
| 45 | Parkinsonism with favorable response to dopaminergic medication (HP:0002548) | 2.08957300 |
| 46 | Anal stenosis (HP:0002025) | 2.07237515 |
| 47 | Basal cell carcinoma (HP:0002671) | 2.07192545 |
| 48 | Gastrointestinal carcinoma (HP:0002672) | 2.05939254 |
| 49 | Malignant gastrointestinal tract tumors (HP:0006749) | 2.05939254 |
| 50 | Oligodactyly (hands) (HP:0001180) | 2.05234164 |
| 51 | Protruding tongue (HP:0010808) | 2.04876701 |
| 52 | Sandal gap (HP:0001852) | 2.03457601 |
| 53 | Transitional cell carcinoma of the bladder (HP:0006740) | 2.01791374 |
| 54 | Heterotopia (HP:0002282) | 1.99333459 |
| 55 | Obsessive-compulsive behavior (HP:0000722) | 1.95562713 |
| 56 | Hereditary nonpolyposis colorectal carcinoma (HP:0006716) | 1.95352457 |
| 57 | Skull defect (HP:0001362) | 1.95074606 |
| 58 | Increased nuchal translucency (HP:0010880) | 1.94181554 |
| 59 | Embryonal neoplasm (HP:0002898) | 1.92981406 |
| 60 | Vertebral arch anomaly (HP:0008438) | 1.92800040 |
| 61 | Biliary tract neoplasm (HP:0100574) | 1.92031855 |
| 62 | Thick eyebrow (HP:0000574) | 1.91647075 |
| 63 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.91481096 |
| 64 | Facial cleft (HP:0002006) | 1.90739638 |
| 65 | Thyroid carcinoma (HP:0002890) | 1.88182223 |
| 66 | Aplasia/Hypoplasia of the frontal sinuses (HP:0009119) | 1.87530913 |
| 67 | Hypoplastic labia majora (HP:0000059) | 1.86635982 |
| 68 | Cafe-au-lait spot (HP:0000957) | 1.85767220 |
| 69 | Abnormality of the nasal septum (HP:0000419) | 1.85490636 |
| 70 | Amaurosis fugax (HP:0100576) | 1.85460021 |
| 71 | Labial hypoplasia (HP:0000066) | 1.83349721 |
| 72 | Deep palmar crease (HP:0006191) | 1.82592245 |
| 73 | Abnormality of the labia minora (HP:0012880) | 1.80857038 |
| 74 | Colon cancer (HP:0003003) | 1.79706503 |
| 75 | Abnormality of the distal phalanx of the thumb (HP:0009617) | 1.79001675 |
| 76 | Abnormality of the parathyroid morphology (HP:0011766) | 1.78707235 |
| 77 | Impaired smooth pursuit (HP:0007772) | 1.78706281 |
| 78 | Uterine leiomyosarcoma (HP:0002891) | 1.78439789 |
| 79 | Leiomyosarcoma (HP:0100243) | 1.78439789 |
| 80 | Abnormality of the columella (HP:0009929) | 1.77282262 |
| 81 | Pancreatic fibrosis (HP:0100732) | 1.77101309 |
| 82 | Drooling (HP:0002307) | 1.76985592 |
| 83 | Partial agenesis of the corpus callosum (HP:0001338) | 1.76084110 |
| 84 | Acute lymphatic leukemia (HP:0006721) | 1.75736042 |
| 85 | Abnormal hair whorl (HP:0010721) | 1.74904926 |
| 86 | Bladder neoplasm (HP:0009725) | 1.74540762 |
| 87 | Bladder carcinoma (HP:0002862) | 1.74540762 |
| 88 | Depressed nasal tip (HP:0000437) | 1.73708064 |
| 89 | Deep philtrum (HP:0002002) | 1.72336441 |
| 90 | Abnormality of chromosome segregation (HP:0002916) | 1.71830053 |
| 91 | Sparse lateral eyebrow (HP:0005338) | 1.69549861 |
| 92 | Excessive salivation (HP:0003781) | 1.69061069 |
| 93 | Omphalocele (HP:0001539) | 1.68766503 |
| 94 | Absent radius (HP:0003974) | 1.68043430 |
| 95 | Nephroblastoma (Wilms tumor) (HP:0002667) | 1.67804399 |
| 96 | Germ cell neoplasia (HP:0100728) | 1.67798464 |
| 97 | Absent eyebrow (HP:0002223) | 1.66556745 |
| 98 | Hypoplastic female external genitalia (HP:0012815) | 1.66469328 |
| 99 | Smooth philtrum (HP:0000319) | 1.66103476 |
| 100 | Abnormality of the carotid arteries (HP:0005344) | 1.66088384 |
| 101 | Intestinal atresia (HP:0011100) | 1.65991768 |
| 102 | Hypoplasia of the maxilla (HP:0000327) | 1.64104243 |
| 103 | Recurrent viral infections (HP:0004429) | 1.63691288 |
| 104 | Abnormality of homocysteine metabolism (HP:0010919) | 1.63383709 |
| 105 | Homocystinuria (HP:0002156) | 1.63383709 |
| 106 | Low anterior hairline (HP:0000294) | 1.63230230 |
| 107 | Cupped ear (HP:0000378) | 1.62715766 |
| 108 | Degeneration of anterior horn cells (HP:0002398) | 1.61427824 |
| 109 | Abnormality of the anterior horn cell (HP:0006802) | 1.61427824 |
| 110 | Hypopigmentation of the fundus (HP:0007894) | 1.59665953 |
| 111 | Deviation of the thumb (HP:0009603) | 1.59633262 |
| 112 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 1.59093329 |
| 113 | Abnormality of the preputium (HP:0100587) | 1.58946624 |
| 114 | Abnormality of ocular smooth pursuit (HP:0000617) | 1.58885344 |
| 115 | Neoplasm of the adrenal cortex (HP:0100641) | 1.58692461 |
| 116 | Tracheomalacia (HP:0002779) | 1.58585530 |
| 117 | Shawl scrotum (HP:0000049) | 1.58365689 |
| 118 | Cutis marmorata (HP:0000965) | 1.57906696 |
| 119 | Hypospadias (HP:0000047) | 1.55429579 |
| 120 | Abnormality of the labia majora (HP:0012881) | 1.55252527 |
| 121 | Aplastic anemia (HP:0001915) | 1.55157653 |
| 122 | Viral hepatitis (HP:0006562) | 1.54612032 |
| 123 | T lymphocytopenia (HP:0005403) | 1.54267614 |
| 124 | Spondylolisthesis (HP:0003302) | 1.54266219 |
| 125 | Uterine neoplasm (HP:0010784) | 1.53761369 |
| 126 | Cortical dysplasia (HP:0002539) | 1.53184862 |
| 127 | Abnormality of the ileum (HP:0001549) | 1.53086056 |
| 128 | Abnormality of the frontal sinuses (HP:0002687) | 1.53060606 |
| 129 | Meckel diverticulum (HP:0002245) | 1.53033841 |
| 130 | Clubbing of toes (HP:0100760) | 1.52979416 |
| 131 | Proximal placement of thumb (HP:0009623) | 1.52832025 |
| 132 | Abnormality of the intervertebral disk (HP:0005108) | 1.52715984 |
| 133 | Intestinal fistula (HP:0100819) | 1.52589582 |
| 134 | Sloping forehead (HP:0000340) | 1.52156309 |
| 135 | Broad thumb (HP:0011304) | 1.52111738 |
| 136 | Highly arched eyebrow (HP:0002553) | 1.51475249 |
| 137 | Lymphoma (HP:0002665) | 1.51290112 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | CDK12 | 4.65582804 |
| 2 | CDC7 | 3.62192967 |
| 3 | TNIK | 3.25597065 |
| 4 | BRD4 | 2.75638988 |
| 5 | SRPK1 | 2.72821122 |
| 6 | LATS1 | 2.44864476 |
| 7 | INSRR | 2.41471822 |
| 8 | CAMK1D | 2.05037084 |
| 9 | FGFR3 | 1.84237456 |
| 10 | ATR | 1.84174651 |
| 11 | TAOK3 | 1.79223678 |
| 12 | WNK1 | 1.78348887 |
| 13 | SIK3 | 1.77454078 |
| 14 | NLK | 1.76668109 |
| 15 | STK38L | 1.69890411 |
| 16 | FRK | 1.69757323 |
| 17 | ZAK | 1.60754098 |
| 18 | NEK2 | 1.60668329 |
| 19 | AKT3 | 1.60621825 |
| 20 | CAMK1G | 1.60212401 |
| 21 | EEF2K | 1.56466212 |
| 22 | ACVR1B | 1.53044040 |
| 23 | MAP3K4 | 1.52013377 |
| 24 | SCYL2 | 1.51857440 |
| 25 | YES1 | 1.45437906 |
| 26 | MAP3K10 | 1.45320236 |
| 27 | PKN2 | 1.43953646 |
| 28 | TAF1 | 1.43083338 |
| 29 | CHEK2 | 1.42403098 |
| 30 | SGK2 | 1.42227974 |
| 31 | MAP4K1 | 1.40574265 |
| 32 | MKNK1 | 1.39376058 |
| 33 | CASK | 1.37218962 |
| 34 | TXK | 1.35079724 |
| 35 | BCR | 1.32075902 |
| 36 | ATM | 1.29706953 |
| 37 | PLK4 | 1.26147899 |
| 38 | MKNK2 | 1.23314117 |
| 39 | MELK | 1.21864379 |
| 40 | CHEK1 | 1.20030267 |
| 41 | MTOR | 1.19445707 |
| 42 | SGK3 | 1.18657765 |
| 43 | BRSK2 | 1.14910906 |
| 44 | CHUK | 1.10614760 |
| 45 | RIPK1 | 1.10402908 |
| 46 | STK3 | 1.07151953 |
| 47 | FGFR2 | 1.03401340 |
| 48 | CDK8 | 1.03154411 |
| 49 | MAP2K7 | 1.02259435 |
| 50 | CDK7 | 1.01841912 |
| 51 | BLK | 1.00496802 |
| 52 | KSR1 | 0.99951974 |
| 53 | MAP3K9 | 0.99045019 |
| 54 | TRIM28 | 0.97578640 |
| 55 | MAP3K6 | 0.97420221 |
| 56 | CDK2 | 0.95097137 |
| 57 | JAK3 | 0.93115884 |
| 58 | PDGFRA | 0.92741623 |
| 59 | CDK9 | 0.92102688 |
| 60 | TAOK1 | 0.91423156 |
| 61 | FGR | 0.90849394 |
| 62 | JAK1 | 0.90211292 |
| 63 | NTRK3 | 0.89664811 |
| 64 | SGK494 | 0.88730509 |
| 65 | AURKB | 0.88497133 |
| 66 | PASK | 0.87973553 |
| 67 | TTK | 0.85950094 |
| 68 | CCNB1 | 0.85802883 |
| 69 | PLK1 | 0.85656829 |
| 70 | RPS6KB1 | 0.85399518 |
| 71 | SMG1 | 0.84421141 |
| 72 | MARK2 | 0.84031843 |
| 73 | CDK1 | 0.83374518 |
| 74 | CDK4 | 0.82791593 |
| 75 | CSNK1A1L | 0.82757742 |
| 76 | ICK | 0.81748927 |
| 77 | FGFR4 | 0.77820149 |
| 78 | PIM1 | 0.77403606 |
| 79 | BRSK1 | 0.76714402 |
| 80 | PLK3 | 0.76482650 |
| 81 | HIPK2 | 0.76392784 |
| 82 | PNCK | 0.73688182 |
| 83 | STK4 | 0.73404451 |
| 84 | CSF1R | 0.72638326 |
| 85 | PBK | 0.69801928 |
| 86 | MAPK14 | 0.68102504 |
| 87 | NUAK1 | 0.68029498 |
| 88 | TSSK6 | 0.67557839 |
| 89 | STK10 | 0.67193071 |
| 90 | CDK6 | 0.66927776 |
| 91 | MAP3K13 | 0.66502946 |
| 92 | BMPR1B | 0.66235346 |
| 93 | SGK1 | 0.64925945 |
| 94 | PDGFRB | 0.64822713 |
| 95 | ALK | 0.64662620 |
| 96 | FLT3 | 0.64003781 |
| 97 | MAPK10 | 0.59819501 |
| 98 | GSK3B | 0.59731306 |
| 99 | STK24 | 0.59115302 |
| 100 | MAP3K7 | 0.58538161 |
| 101 | MAP3K5 | 0.57057476 |
| 102 | DAPK1 | 0.56535722 |
| 103 | CDC42BPA | 0.55687420 |
| 104 | CAMK4 | 0.55666281 |
| 105 | PRKAA2 | 0.55317574 |
| 106 | DYRK3 | 0.53341879 |
| 107 | EIF2AK1 | 0.52429425 |
| 108 | PRKDC | 0.52403392 |
| 109 | VRK1 | 0.51959412 |
| 110 | EGFR | 0.51885165 |
| 111 | CDK3 | 0.51442900 |
| 112 | RAF1 | 0.50759982 |
| 113 | NEK6 | 0.50685561 |
| 114 | MAP3K14 | 0.49498507 |
| 115 | ERBB2 | 0.48608263 |
| 116 | WNK3 | 0.48039987 |
| 117 | RET | 0.47892874 |
| 118 | PRKAA1 | 0.47301598 |
| 119 | TEC | 0.46831817 |
| 120 | CSNK1E | 0.46233477 |
| 121 | CSNK1D | 0.45355024 |
| 122 | MAPK8 | 0.45135406 |
| 123 | MARK3 | 0.44639834 |
| 124 | ITK | 0.44570000 |
| 125 | DMPK | 0.44299039 |
| 126 | EIF2AK3 | 0.44027849 |
| 127 | RPS6KA4 | 0.43711549 |
| 128 | SIK1 | 0.42305288 |
| 129 | FGFR1 | 0.41236159 |
| 130 | MAPK1 | 0.40861875 |
| 131 | MAP3K2 | 0.39648358 |
| 132 | PRPF4B | 0.39582436 |
| 133 | RPS6KB2 | 0.39350835 |
| 134 | AKT1 | 0.39221766 |
| 135 | STK11 | 0.39065518 |
| 136 | JAK2 | 0.39007470 |
| 137 | SGK223 | 0.37501669 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Cell cycle_Homo sapiens_hsa04110 | 2.32433727 |
| 2 | Mismatch repair_Homo sapiens_hsa03430 | 2.22764749 |
| 3 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.13878982 |
| 4 | RNA degradation_Homo sapiens_hsa03018 | 1.91824301 |
| 5 | DNA replication_Homo sapiens_hsa03030 | 1.80045898 |
| 6 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.78727165 |
| 7 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.73262481 |
| 8 | Colorectal cancer_Homo sapiens_hsa05210 | 1.71314303 |
| 9 | Lysine degradation_Homo sapiens_hsa00310 | 1.68944134 |
| 10 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.59917050 |
| 11 | RNA transport_Homo sapiens_hsa03013 | 1.58829481 |
| 12 | Base excision repair_Homo sapiens_hsa03410 | 1.57520501 |
| 13 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 1.50451318 |
| 14 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.49979520 |
| 15 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 1.36796767 |
| 16 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 1.36741342 |
| 17 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.36168388 |
| 18 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.35918744 |
| 19 | mTOR signaling pathway_Homo sapiens_hsa04150 | 1.33270230 |
| 20 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.28467325 |
| 21 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 1.27861442 |
| 22 | Renal cell carcinoma_Homo sapiens_hsa05211 | 1.27392385 |
| 23 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.23040253 |
| 24 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.20738835 |
| 25 | Pancreatic cancer_Homo sapiens_hsa05212 | 1.20333219 |
| 26 | Homologous recombination_Homo sapiens_hsa03440 | 1.19009038 |
| 27 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.18474147 |
| 28 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.18293634 |
| 29 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 1.17978849 |
| 30 | Endometrial cancer_Homo sapiens_hsa05213 | 1.17892868 |
| 31 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.16325840 |
| 32 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.16180887 |
| 33 | Alcoholism_Homo sapiens_hsa05034 | 1.15323252 |
| 34 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 1.14701567 |
| 35 | Basal cell carcinoma_Homo sapiens_hsa05217 | 1.14689753 |
| 36 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.11579729 |
| 37 | Spliceosome_Homo sapiens_hsa03040 | 1.09280659 |
| 38 | Hippo signaling pathway_Homo sapiens_hsa04390 | 1.06698289 |
| 39 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 1.06226662 |
| 40 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 1.06163007 |
| 41 | Hepatitis B_Homo sapiens_hsa05161 | 1.05456600 |
| 42 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.05441037 |
| 43 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.03472301 |
| 44 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 1.03407935 |
| 45 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 1.02831180 |
| 46 | Tight junction_Homo sapiens_hsa04530 | 1.00825367 |
| 47 | Glioma_Homo sapiens_hsa05214 | 1.00802393 |
| 48 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.99757814 |
| 49 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.97553114 |
| 50 | HTLV-I infection_Homo sapiens_hsa05166 | 0.95698342 |
| 51 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.95244167 |
| 52 | Prostate cancer_Homo sapiens_hsa05215 | 0.94687737 |
| 53 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.91476639 |
| 54 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.91298841 |
| 55 | Adherens junction_Homo sapiens_hsa04520 | 0.89483552 |
| 56 | Basal transcription factors_Homo sapiens_hsa03022 | 0.89301121 |
| 57 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.88675228 |
| 58 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.87803844 |
| 59 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.87694167 |
| 60 | Long-term potentiation_Homo sapiens_hsa04720 | 0.86453297 |
| 61 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.86228894 |
| 62 | Thyroid cancer_Homo sapiens_hsa05216 | 0.84885449 |
| 63 | Insulin secretion_Homo sapiens_hsa04911 | 0.84678085 |
| 64 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.83468981 |
| 65 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.82613491 |
| 66 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.81683815 |
| 67 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.81020875 |
| 68 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.80083786 |
| 69 | Olfactory transduction_Homo sapiens_hsa04740 | 0.79405553 |
| 70 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.79011915 |
| 71 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.78428236 |
| 72 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.78065376 |
| 73 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.77347736 |
| 74 | Influenza A_Homo sapiens_hsa05164 | 0.75485550 |
| 75 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.75189762 |
| 76 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.74471784 |
| 77 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.72839957 |
| 78 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.72063531 |
| 79 | Hepatitis C_Homo sapiens_hsa05160 | 0.71830630 |
| 80 | Measles_Homo sapiens_hsa05162 | 0.71746163 |
| 81 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.70605673 |
| 82 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.70573074 |
| 83 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.70480365 |
| 84 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.69344395 |
| 85 | Melanoma_Homo sapiens_hsa05218 | 0.67157716 |
| 86 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.66130344 |
| 87 | Viral myocarditis_Homo sapiens_hsa05416 | 0.64321360 |
| 88 | Apoptosis_Homo sapiens_hsa04210 | 0.64089351 |
| 89 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.64065706 |
| 90 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.64023423 |
| 91 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.62849733 |
| 92 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.61789957 |
| 93 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.61612905 |
| 94 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.61538981 |
| 95 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.61518852 |
| 96 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.61321405 |
| 97 | Melanogenesis_Homo sapiens_hsa04916 | 0.61160174 |
| 98 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.60796376 |
| 99 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.60573278 |
| 100 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.60508781 |
| 101 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.60201335 |
| 102 | Insulin resistance_Homo sapiens_hsa04931 | 0.60094409 |
| 103 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.58784593 |
| 104 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.58263192 |
| 105 | Shigellosis_Homo sapiens_hsa05131 | 0.55917240 |
| 106 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.55874370 |
| 107 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.55382569 |
| 108 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.55363104 |
| 109 | Long-term depression_Homo sapiens_hsa04730 | 0.55144246 |
| 110 | Pathways in cancer_Homo sapiens_hsa05200 | 0.54700272 |
| 111 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.54065303 |
| 112 | Osteoclast differentiation_Homo sapiens_hsa04380 | 0.53057474 |
| 113 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.53006012 |
| 114 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.52522165 |
| 115 | Platelet activation_Homo sapiens_hsa04611 | 0.52060570 |
| 116 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.51998746 |
| 117 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.51833941 |
| 118 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.51082734 |
| 119 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.49291914 |
| 120 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.49112460 |
| 121 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.48884569 |
| 122 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.48566756 |
| 123 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.48189359 |
| 124 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.47622060 |
| 125 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.47271908 |
| 126 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.45466311 |
| 127 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.44206320 |
| 128 | Axon guidance_Homo sapiens_hsa04360 | 0.41633976 |
| 129 | Bladder cancer_Homo sapiens_hsa05219 | 0.41447483 |

